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Information on EC 2.7.11.15 - beta-adrenergic-receptor kinase and Organism(s) Drosophila melanogaster and UniProt Accession P32866

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EC Tree
IUBMB Comments
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
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This record set is specific for:
Drosophila melanogaster
UNIPROT: P32866
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
g protein-coupled receptor kinase 2, beta-adrenergic receptor kinase, betaark1, betaark, g-protein-coupled receptor kinase 2, gprk2, g protein-coupled receptor kinase-2, beta-adrenergic receptor kinase 1, g protein coupled receptor kinase, beta-ark, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G protein-coupled receptor kinase 2
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G protein-coupled receptor regulatory kinase 2
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beta-adrenergic receptor kinase
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beta-adrenergic receptor-specific kinase
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beta-AR kinase
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beta-ARK
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-
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beta-ARK 1
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-
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beta-ARK 2
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beta-receptor kinase
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-
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G protein-coupled receptor kinase 2
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G protein-coupled receptor regulatory kinase
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GRK3
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kinase (phosphorylating), beta-adrenergic-receptor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[beta-adrenergic receptor] phosphotransferase
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
102925-39-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + Smo
ADP + phosphorylated Smo
show the reaction diagram
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + Smo
ADP + phosphorylated Smo
show the reaction diagram
GPRK2 participates in Hedgehog signaling in Drosophila melanogaster, and plays a key role in the Smo signal transduction pathway, when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced, overview
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?
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
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GRK2 expression analysis in different developmental stages, the expression is required in the germline
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GPRK2_DROME
714
0
80686
Swiss-Prot
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of GRK2-fusion constructs in transgenic flies, expression analysis, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cassill, J.A.; Whitney, M.; Joazeiro, C.A.; Becker, A.; Zuker, C.S.
Isolation of Drosophila genes encoding G protein-coupled receptor kinases
Proc. Natl. Acad. Sci. USA
88
11067-11070
1991
Drosophila melanogaster (P32866)
Manually annotated by BRENDA team
Schneider, L.E.; Spradling, A.C.
The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis
Development
124
2591-2602
1997
Drosophila melanogaster (P32866)
Manually annotated by BRENDA team
Fan, S.; Schneider, L.E.
The role of maternal and zygotic Gprk2 expression in Drosophila development
Biochem. Biophys. Res. Commun.
301
127-135
2003
Drosophila melanogaster
Manually annotated by BRENDA team
Molnar, C.; Holguin, H.; Mayor, F.; Ruiz-Gomez, A.; de Celis, J.F.
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
Proc. Natl. Acad. Sci. USA
104
7963-7968
2007
Drosophila melanogaster, Drosophila melanogaster (P32866)
Manually annotated by BRENDA team
Cheng, S.; Maier, D.; Hipfner, D.R.
Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling
Development
139
85-94
2012
Drosophila melanogaster
Manually annotated by BRENDA team
Valanne, S.; Myllymaeki, H.; Kallio, J.; Schmid, M.R.; Kleino, A.; Murumaegi, A.; Airaksinen, L.; Kotipelto, T.; Kaustio, M.; Ulvila, J.; Esfahani, S.S.; Engstroem, Y.; Silvennoinen, O.; Hultmark, D.; Parikka, M.; Raemet, M.
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling
J. Immunol.
184
6188-6198
2010
Danio rerio, Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team