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Information on EC 2.7.11.14 - rhodopsin kinase and Organism(s) Gallus gallus and UniProt Accession O73685

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EC Tree
IUBMB Comments
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
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This record set is specific for:
Gallus gallus
UNIPROT: O73685
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
rk, rhodopsin kinase, g protein-coupled receptor kinase, g-protein receptor kinase, g-protein coupled receptor kinase, g protein-coupled receptor kinase 1, g-protein coupled receptor kinase 1, gprk1, g-protein-coupled receptor kinase 1, g protein receptor kinase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G protein-coupled receptor kinase 1
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GPCR kinase 1
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GRK1
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kinase (phosphorylating), opsin
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kinase (phosphorylating), rhodopsin
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opsin kinase
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RK
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:rhodopsin phosphotransferase
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
54004-64-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + rhodopsin
ADP + phosphorhodopsin
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + rhodopsin
ADP + phosphorhodopsin
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
O73685_CHICK
593
0
64660
TrEMBL
Secretory Pathway (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * about 61000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
side-chain modification
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
from whole retina
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of one GRK1 from cone-dominant retina
GRK1 from retina and pineal gland is cloned and sequenced
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhao, X.; Yokoyama, K.; Whitten, M.E.; Huang, J.; Gelb, M.H.; Palczewski, K.
A novel form of rhodopsin kinase from chicken retina and pineal gland
FEBS Lett.
454
115-121
1999
Bos taurus, Gallus gallus (O73685), Gallus gallus
Manually annotated by BRENDA team
Zhao, X.; Huang, J.; Khani, S.C.; Palczewski, K.
Molecular forms of human rhodopsin kinase (GRK1)
J. Biol. Chem.
273
5124-5131
1998
Homo sapiens, Gallus gallus (O73685), Gallus gallus
Manually annotated by BRENDA team
Maeda, T.; Imanishi, Y.; Palczewski, K.
Rhodopsin phosphorylation: 30 years later
Prog. Retin. Eye Res.
22
417-434
2003
Bos taurus, Homo sapiens, Homo sapiens (Q15835), Oryzias latipes, Mus musculus, Rattus norvegicus, Gallus gallus (O73685), Enteroctopus dofleini (O97020), Doryteuthis pealeii (Q9N2R0)
Manually annotated by BRENDA team