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Information on EC 2.7.11.13 - protein kinase C and Organism(s) Caenorhabditis elegans and UniProt Accession P34885

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IUBMB Comments
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
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This record set is specific for:
Caenorhabditis elegans
UNIPROT: P34885
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The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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ATP
+
a [protein]-(L-serine/L-threonine)
=
ADP
+
a [protein]-(L-serine/L-threonine) phosphate
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase c, pkcalpha, pkc-alpha, pkc alpha, pkcepsilon, pkc-delta, pkczeta, pkc-epsilon, pkc delta, pkc-zeta, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
protein kinase C-like 2
-
Calcium-dependent protein kinase C
-
-
-
-
epsilonPKC
-
-
-
-
protein kinase C
-
-
-
-
protein kinase C-like 1
-
protein kinase-C
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (diacylglycerol-dependent)
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
CAS REGISTRY NUMBER
COMMENTARY hide
141436-78-4
calcium-dependent protein kinase C
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
PKC isozymes are involved in signal transduction, required for host defense
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
PKC isozymes are involved in signal transduction, required for host defense
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
abundant at the earliest larval stage, but their relative concentrations decrease coordinately in late larvae
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KPC1B_CAEEL
707
0
80151
Swiss-Prot
Mitochondrion (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sano, T.; Tabuse, Y.; Nishiwaki, K.; Miwa, J.
The tpa-1 gene of Caenorhabditis elegans encodes two proteins similar to Ca(2+)-independent protein kinase Cs: evidence by complete genomic and complementary DNA sequences of the tpa-1 gene
J. Mol. Biol.
251
477-485
1995
Caenorhabditis elegans (P34722), Caenorhabditis elegans
Manually annotated by BRENDA team
Tabuse, Y.; Nishiwaki, K.; Miwa, J.
Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans
Science
243
1713-1716
1989
Caenorhabditis elegans (P34722), Caenorhabditis elegans
Manually annotated by BRENDA team
Land, M.; Islas-Trejo, A.; Freedman, J.H.; Rubin, C.S.
Structure and expression of a novel, neuronal protein kinase C (PKC1B) from Caenorhabditis elegans. PKC1B is expressed selectively in neurons that receive, transmit, and process environmental signals
J. Biol. Chem.
269
9234-9244
1994
Caenorhabditis elegans (P34885), Caenorhabditis elegans
Manually annotated by BRENDA team
Spitaler, M.; Cantrell, D.A.
Protein kinase C and beyond
Nat. Immunol.
5
785-790
2004
Caenorhabditis elegans, Homo sapiens, Solanum lycopersicum, Mus musculus
Manually annotated by BRENDA team