Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + BKCa channel protein
ADP + BKCa channel phosphoprotein
-
phosphorylation at Ser691, Ser873, and Ser1112 on recombinant Mus musculus BKCa channels expressed in Rattus norvegicus aortic A7r5 smooth muscle cells or in humn in HEK 293 cells
-
-
?
ATP + CFTR
ADP + phosphorylated CFTR
ATP + CREb protein
ADP + phosphorylated CREb protein
-
-
-
-
?
ATP + GluA1 protein
ADP + GluA1 phosphoprotein
-
phosphorylation at Ser845 by type II cGMP-dependent protein kinase
-
-
?
ATP + glycogen synthase kinase-3
ADP + phosphorylated glycogen synthase kinase 3
-
phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis
-
-
?
ATP + glycogen synthase kinase3
ADP + phosphorylated glycogen synthase kinase 3
-
phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3, substrate phosphorylation site mapping
-
-
?
ATP + GRRESLTSFG
ADP + phosphorylated GRRESLTSFG
-
-
-
-
?
ATP + Maxi-K channel
ADP + phosphorylated Maxi-K channel
-
-
-
-
?
ATP + Na+/K+ ATPase
ADP + phosphorylated Na+/K+ ATPase
ATP + steroidogenic acute regulatory protein
ADP + phosphorylated steroidogenic acute regulatory protein
-
i.e. StAR, recombinant GST-tagged substrate expressed in HEK-293 cells, phosphorylation in vitro at Ser55, Ser56, and Ser99
-
-
?
ATP + target membrane SNARe complex
ADP + phosphorylated target membrane SNARe complex
-
the enzyme is involved in regulation of degranulation of leukocytes by phosphorylation of target membrane SNARe complex together with the phosphoinositide 3-kinase
-
-
?
ATP + transient receptor potential channel 6
ADP + phosphorylated transient receptor potential channel 6
-
PKG phosphorylation is reduced in transient receptor potential channel 6 mutant T69A
-
-
?
ATP + VASP protein
ADP + phosphorylated VASP protein
-
-
-
-
?
additional information
?
-
ATP + CFTR
ADP + phosphorylated CFTR
-
phosphorylation leads to stimulation of chloride channels
-
-
?
ATP + CFTR
ADP + phosphorylated CFTR
-
phosphorylation by cGKI and cGKII
-
-
?
ATP + Na+/K+ ATPase
ADP + phosphorylated Na+/K+ ATPase
-
-
-
-
?
ATP + Na+/K+ ATPase
ADP + phosphorylated Na+/K+ ATPase
-
the enzyme has a positive regulatory function on the ion pump activity induced by No and glutamate via increased cGMP, overview
-
-
?
additional information
?
-
-
alternative splicing of PKGI in angiotensin-hypertension, mechanism for nitrate tolerance in vascular smooth muscle
-
-
?
additional information
?
-
-
cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3
-
-
?
additional information
?
-
-
PKGII regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene
-
-
?
additional information
?
-
-
the enzyme is required for adenosine-induced dilation of intracerebral arterioles and thus in regulation of cerebral blood flow, mechanism
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation at serines 110, 114, 117, 126, and 445 and at Thr109 in vitro and in vivo
-
-
?
additional information
?
-
-
the phorbol myristate acetate-stimulated PKC isozyme activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase
-
-
?
additional information
?
-
-
cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview
-
-
?
additional information
?
-
-
PKG I plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, regulation of PKG I expression by Rho and Kruppel-like transcription factor-4, RhoA is involved in decreased PKG I levels in vascular smooth muscle cells found in some models of hypertension and vascular injury, overview
-
-
?
additional information
?
-
-
transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview
-
-
?
additional information
?
-
-
PKG phosphorylates several substrates and interacts, by engaging its N-terminal, with numerous proteins
-
-
?
additional information
?
-
-
serine to alanine substitutions at 3 of 6 putative cGKI phosphorylation sites, Ser691, Ser873, and Ser1112, in the BKCa alpha-subunit and mutant expression in A7r5 cells individually reduce direct channel phosphorylation by 25-60% and block BKCa activation by either an NO donor or a membrane-permeable cGMP by 80-100%
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + CFTR
ADP + phosphorylated CFTR
-
phosphorylation leads to stimulation of chloride channels
-
-
?
ATP + CREb protein
ADP + phosphorylated CREb protein
-
-
-
-
?
ATP + GluA1 protein
ADP + GluA1 phosphoprotein
-
phosphorylation at Ser845 by type II cGMP-dependent protein kinase
-
-
?
ATP + glycogen synthase kinase-3
ADP + phosphorylated glycogen synthase kinase 3
-
phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis
-
-
?
ATP + Na+/K+ ATPase
ADP + phosphorylated Na+/K+ ATPase
-
the enzyme has a positive regulatory function on the ion pump activity induced by No and glutamate via increased cGMP, overview
-
-
?
ATP + target membrane SNARe complex
ADP + phosphorylated target membrane SNARe complex
-
the enzyme is involved in regulation of degranulation of leukocytes by phosphorylation of target membrane SNARe complex together with the phosphoinositide 3-kinase
-
-
?
additional information
?
-
additional information
?
-
-
alternative splicing of PKGI in angiotensin-hypertension, mechanism for nitrate tolerance in vascular smooth muscle
-
-
?
additional information
?
-
-
cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3
-
-
?
additional information
?
-
-
PKGII regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene
-
-
?
additional information
?
-
-
the enzyme is required for adenosine-induced dilation of intracerebral arterioles and thus in regulation of cerebral blood flow, mechanism
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation at serines 110, 114, 117, 126, and 445 and at Thr109 in vitro and in vivo
-
-
?
additional information
?
-
-
the phorbol myristate acetate-stimulated PKC isozyme activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase
-
-
?
additional information
?
-
-
cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview
-
-
?
additional information
?
-
-
PKG I plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, regulation of PKG I expression by Rho and Kruppel-like transcription factor-4, RhoA is involved in decreased PKG I levels in vascular smooth muscle cells found in some models of hypertension and vascular injury, overview
-
-
?
additional information
?
-
-
transcriptional regulation by the cgMP/PKG pathway affects the amount of IL-6 expression, cGMP-induced PKG activates the IL-6 promoter involving cis-acting DNA elements and transcription factors, the activation is prevented by actinomycin D, regulation system, overview
-
-
?
additional information
?
-
-
PKG phosphorylates several substrates and interacts, by engaging its N-terminal, with numerous proteins
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Jarchau, T.; Hausler, C.; Markert, T.; Pohler, D.; Vanderkerckhove, J.; De Jonge, H.R.; Lohmann, S.M.; Walter, U.
Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II
Proc. Natl. Acad. Sci. USA
91
9426-9430
1994
Rattus norvegicus (Q64595)
brenda
Barman, S.A.; Zhu, S.; White, R.E.
PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase
Am. J. Physiol.
286
L1275-1281
2004
Rattus norvegicus
brenda
Munhoz, C.D.; Kawamoto, E.M.; de Sa Lima, L.; Lepsch, L.B.; Glezer, I.; Marcourakis, T.; Scavone, C.
Glutamate modulates sodium-potassium-ATPase through cyclic GMP and cyclic GMP-dependent protein kinase in rat striatum
Cell Biochem. Funct.
23
115-123
2005
Rattus norvegicus
brenda
Gerzanich, V.; Ivanov, A.; Ivanova, S.; Yang, J.B.; Zhou, H.; Dong, Y.; Simard, J.M.
Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle
Circ. Res.
93
805-812
2003
Rattus norvegicus
brenda
Schlossmann, J.; Hofmann, F.
cGMP-dependent protein kinases in drug discovery
Drug Discov. Today
10
627-634
2005
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Vaandrager, A.B.; Hogema, B.M.; Edixhoven, M.; van den Burg, C.M.; Bot, A.G.; Klatt, P.; Ruth, P.; Hofmann, F.; Van Damme, J.; Vandekerckhove, J.; de Jonge, H.R.
Autophosphorylation of cGMP-dependent protein kinase type II
J. Biol. Chem.
278
28651-28658
2003
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Gambaryan, S.; Butt, E.; Marcus, K.; Glazova, M.; Palmetshofer, A.; Guillon, G.; Smolenski, A.
cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene
J. Biol. Chem.
278
29640-29648
2003
Rattus norvegicus
brenda
Zhao, X.; Zhuang, S.; Chen, Y.; Boss, G.R.; Pilz, R.B.
Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3
J. Biol. Chem.
280
32683-32692
2005
Rattus norvegicus
brenda
West, G.A.; Meno, J.R.; Nguyen, T.S.; Ngai, A.C.; Simard, J.M.; Winn, H.R.
cGMP-dependent and not cAMP-dependent kinase is required for adenosine-induced dilation of intracerebral arterioles
J. Cardiovasc. Pharmacol.
41
444-451
2003
Rattus norvegicus
brenda
Zeng, Y.; Zhuang, S.; Gloddek, J.; Tseng, C.C.; Boss, G.R.; Pilz, R.B.
Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4
J. Biol. Chem.
281
16951-16961
2006
Rattus norvegicus
brenda
Fiedler, B.; Feil, R.; Hofmann, F.; Willenbockel, C.; Drexler, H.; Smolenski, A.; Lohmann, S.M.; Wollert, K.C.
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes
J. Biol. Chem.
281
32831-32840
2006
Mus musculus, Mus musculus C57BL/6, Rattus norvegicus
brenda
Nanamori, M.; Chen, J.; Du, X.; Ye, R.D.
Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells
J. Immunol.
178
416-427
2007
Rattus norvegicus
brenda
Broderick, K.E.; Zhang, T.; Rangaswami, H.; Zeng, Y.; Zhao, X.; Boss, G.R.; Pilz, R.B.
Guanosine 3,5-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts
Mol. Endocrinol.
21
1148-1162
2007
Homo sapiens, Rattus norvegicus
brenda
Chen, G.D.; Peng, M.L.; Wang, P.Y.; Lee, S.D.; Chang, H.M.; Pan, S.F.; Chen, M.J.; Tung, K.C.; Lai, C.Y.; Lin, T.B.
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R487-R493
2008
Rattus norvegicus
brenda
Hernandez-Pacheco, A.; Araiza-Saldana, C.I.; Granados-Soto, V.; Mixcoatl-Zecuatl, T.
Possible participation of the nitric oxide-cyclic GMP-protein kinase G-K+ channels pathway in the peripheral antinociception of melatonin
Eur. J. Pharmacol.
596
70-76
2008
Rattus norvegicus
brenda
Boran, M.S.; Baltrons, M.A.; Garcia, A.
The ANP-cGMP-protein kinase G pathway induces a phagocytic phenotype but decreases inflammatory gene expression in microglial cells
Glia
56
394-411
2008
Rattus norvegicus
brenda
Takahashi, S.; Lin, H.; Geshi, N.; Mori, Y.; Kawarabayashi, Y.; Takami, N.; Mori, M.X.; Honda, A.; Inoue, R.
Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6
J. Physiol.
586
4209-4223
2008
Homo sapiens, Rattus norvegicus
brenda
Wang, S.; Li, Y.
Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation
Am. J. Physiol. Heart Circ. Physiol.
297
H2075-H2083
2009
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Nickl, C.K.; Raidas, S.K.; Zhao, H.; Sausbier, M.; Ruth, P.; Tegge, W.; Brayden, J.E.; Dostmann, W.R.
(D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha
Biochim. Biophys. Acta
1804
524-532
2010
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Incontro, S.; Ciruela, F.; Ziff, E.; Hofmann, F.; Sanchez-Prieto, J.; Torres, M.
The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells
Biochim. Biophys. Acta
1833
1820-1831
2013
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Sellak, H.; Choi, C.S.; Dey, N.B.; Lincoln, T.M.
Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance
Cardiovasc. Res.
97
200-207
2013
Bos taurus, Oryctolagus cuniculus, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Castro, L.R.; Schittl, J.; Fischmeister, R.
Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes
Circ. Res.
107
1232-1240
2010
Rattus norvegicus
brenda
Kyle, B.D.; Hurst, S.; Swayze, R.D.; Sheng, J.; Braun, A.P.
Specific phosphorylation sites underlie the stimulation of a large conductance, Ca2+-activated K+ channel by cGMP-dependent protein kinase
FASEB J.
27
2027-2038
2013
Bos taurus, Rattus norvegicus
brenda
Chen, J.; Roberts, J.D.
cGMP-dependent protein kinase I gamma encodes a nuclear localization signal that regulates nuclear compartmentation and function
Cell. Signal.
26
2633-2644
2014
Rattus norvegicus
brenda
Ramdani, G.; Schall, N.; Kalyanaraman, H.; Wahwah, N.; Moheize, S.; Lee, J.J.; Sah, R.L.; Pfeifer, A.; Casteel, D.E.; Pilz, R.B.
cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss
J. Endocrinol.
238
203-219
2018
Rattus norvegicus
brenda