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Acidosis
Effect of acidosis on heart cAMP-dependent protein kinase.
Acidosis
Effect of metabolic acidosis on renal response to parathyroid hormone in phosphorus-deprived rats.
Acidosis
Effect of pH on lipolysis, cAMP and cAMP-dependent protein kinase activity in isolated rat fat cells.
Acquired Immunodeficiency Syndrome
Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells.
ACTH-Secreting Pituitary Adenoma
Genomic insights into Cushing syndrome.
ACTH-Secreting Pituitary Adenoma
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
Adenocarcinoma
CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway.
Adenocarcinoma
Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus.
Adenocarcinoma
Parallel activation of cyclic AMP phosphodiesterase and cyclic AMP-dependent protein kinase in two human gut adenocarcinoma cells (HT 29 and HRT 18) in culture, by vasoactive intestinal peptide (VIP) and other effectors activating the cyclic AMP system.
Adenocarcinoma
Protein kinase A activation of the surfactant protein B gene is mediated by phosphorylation of thyroid transcription factor 1.
Adenocarcinoma of Lung
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Adenocarcinoma, Follicular
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
Adenoma
A genetic and molecular update on adrenocortical causes of Cushing syndrome.
Adenoma
cAMP signaling in cortisol-producing adrenal adenoma.
Adenoma
Clinical characteristics of PRKACA mutations in Chinese patients with adrenal lesions: a single-centre study.
Adenoma
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Adenoma
Functional changes in the regulatory subunit of the type II cyclic adenosine 3':5'-monophosphate-dependent protein kinase isozyme during normal and neoplastic lung development.
Adenoma
Genetic Causes of Functional Adrenocortical Adenomas.
Adenoma
Genomic insights into Cushing syndrome.
Adenoma
Genomics of benign adrenocortical tumors.
Adenoma
Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.
Adenoma
GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24.
Adenoma
GNAS mutations in adrenal aldosterone-producing adenomas [Rapid Communication].
Adenoma
Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss.
Adenoma
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Adenoma
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Adenoma
Human GHRH reduces voltage-gated K+ currents via a non-cAMP-dependent but PKC-mediated pathway in human GH adenoma cells.
Adenoma
Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.
Adenoma
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
Adenoma
Lipofuscin Accumulation in Cortisol-Producing Adenomas With and Without PRKACA Mutations.
Adenoma
Molecular Basis of Primary Aldosteronism and Adrenal Cushing Syndrome.
Adenoma
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Adenoma
PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.
Adenoma
PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia - a single-center study of 60 cases.
Adenoma
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.
Adenoma
Protein kinase A defects and cortisol-producing adrenal tumors.
Adenoma
RNA-Sequencing and Somatic Mutation Status of Adrenocortical Tumors: Novel Pathogenetic Insights.
Adenoma
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
Adenoma
Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.
Adenoma
The genetics of adrenocortical tumors.
Adenoma
Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016).
Adenoma, Liver Cell
Update on the pathology of liver neoplasms.
Adrenocortical Adenoma
5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.
Adrenocortical Adenoma
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Adrenocortical Adenoma
cAMP signaling in cortisol-producing adrenal adenoma.
Adrenocortical Adenoma
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Adrenocortical Adenoma
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
Adrenocortical Adenoma
Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.
Adrenocortical Adenoma
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
Adrenocortical Adenoma
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
Adrenocortical Adenoma
Mechanisms of Aberrant PKA Activation by C? Subunit Mutations.
Adrenocortical Adenoma
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Adrenocortical Adenoma
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Adrenocortical Adenoma
PKA C? subunit mutation triggers caspase-dependent RII? subunit degradation via Ser114 phosphorylation.
Adrenocortical Adenoma
PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.
Adrenocortical Adenoma
Protein kinase A alterations in adrenocortical tumors.
Adrenocortical Adenoma
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
Adrenocortical Adenoma
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Adrenocortical Carcinoma
Cisplatin resistance and regulation of DNA repair in cAMP-dependent protein kinase mutants.
Adrenocortical Carcinoma
Cisplatin sensitivity in cAMP-dependent protein kinase mutants of Saccharomyces cerevisiae.
Adrenocortical Carcinoma
Clinical characteristics of PRKACA mutations in Chinese patients with adrenal lesions: a single-centre study.
Adrenocortical Carcinoma
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Adrenocortical Carcinoma
Genomic insights into Cushing syndrome.
Adrenocortical Carcinoma
Partial purification and characterization of the defective cyclic adenosine 3':5'-monophosphate binding protein kinase from adrenocortical carcinoma.
Adrenocortical Carcinoma
Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.
Albinism, Oculocutaneous
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
Alcohol Withdrawal Seizures
Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.
Alkalosis
Effect of pH on lipolysis, cAMP and cAMP-dependent protein kinase activity in isolated rat fat cells.
Alzheimer Disease
A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Alzheimer Disease
cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer disease.
Alzheimer Disease
cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.
Alzheimer Disease
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer's disease.
Alzheimer Disease
Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.
Alzheimer Disease
Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain.
Alzheimer Disease
Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's disease.
Alzheimer Disease
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Alzheimer Disease
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
Alzheimer Disease
Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale.
Alzheimer Disease
Regional localization of the regulatory subunit (RII beta) of the type II cAMP-dependent protein kinase in human brain.
Anthrax
Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A (PKA) and exchange protein activated by cAMP (Epac) pathways.
Arrhythmias, Cardiac
Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes.
Asthma
?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.
Asthma
Calcitonin Gene-Related Peptide and Cyclic Adenosine 5'-Monophosphate/Protein Kinase A Pathway Promote IL-9 Production in Th9 Differentiation Process.
Astrocytoma
Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.
Astrocytoma
Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.
Astrocytoma
Proteomic studies on low- and high-grade human brain astrocytomas.
Ataxia
Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques.
Ataxia
Sustained antagonism of acute ethanol-induced ataxia following microinfusion of cyclic AMP and cpt-cAMP in the mouse cerebellum.
Atherosclerosis
Intermedin Ameliorates Atherosclerosis by Increasing Cholesterol Efflux Through the cAMP-PKA Pathway in Macrophage RAW264.7 Cell Line.
Biliary Tract Neoplasms
Second-line therapies in advanced biliary tract cancers.
Bone Neoplasms
Activation of the cAMP-PKA signaling pathway in rat dorsal root ganglion and spinal cord contributes toward induction and maintenance of bone cancer pain.
Bone Neoplasms
Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury.
Bone Neoplasms
Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord.
Bone Resorption
cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts.
Bone Resorption
Differential effects of the 3',5'-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin.
Bone Resorption
Role of dual signal transduction systems in the stimulation of bone resorption by parathyroid hormone-related peptide. The direct involvement of cAMP-dependent protein kinase.
Bone Resorption
The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone.
Bone Resorption
[Effects of calcitonin on osteoclast]
Bradycardia
5-HT(4) receptors in nucleus tractus solitarii attenuate cardiopulmonary reflex in anesthetized rats.
Brain Injuries, Traumatic
Age-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injury.
Brain Ischemia
A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat.
Brain Ischemia
Alteration of second messengers during acute cerebral ischemia - adenylate cyclase, cyclic AMP-dependent protein kinase, and cyclic AMP response element binding protein.
Brain Ischemia
Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats.
Brain Ischemia
Inhibition of cyclic AMP-dependent protein kinase in the acute phase of focal cerebral ischemia in the rat.
Brain Neoplasms
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Breast Neoplasms
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Breast Neoplasms
Characteristics of selective activation of cyclic AMP-dependent protein kinase isoenzymes by calcitonin and prostaglandin E2 in human breast cancer cells.
Breast Neoplasms
Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.
Breast Neoplasms
Differential regulation of ErbB2 expression by cAMP-dependent protein kinase in tamoxifen-resistant breast cancer cells.
Breast Neoplasms
Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector.
Breast Neoplasms
IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells.
Breast Neoplasms
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells.
Breast Neoplasms
Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells.
Breast Neoplasms
Mitotic apparatus and nucleoli compartmentalization of 50,000-dalton type II regulatory subunit of cAMP-dependent protein kinase in estrogen receptor negative MDA-MB-231 human breast cancer cells.
Breast Neoplasms
Nucleolar accumulation of cyclic adenosine 3':5'-monophosphate receptor proteins during regression of MCF-7 human breast tumor.
Breast Neoplasms
PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.
Breast Neoplasms
Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase.
Breast Neoplasms
Regulation of multidrug resistance through the cAMP and EGF signalling pathways.
Breast Neoplasms
Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.
Breast Neoplasms
The biphasic induction of p21 and p27 in breast cancer cells by modulators of cAMP is posttranscriptionally regulated and independent of the PKA pathway.
Breast Neoplasms
Transcriptional regulation of multidrug resistance in breast cancer.
Brucellosis
Subversion and utilization of the host cell cyclic adenosine 5'-monophosphate/protein kinase A pathway by Brucella during macrophage infection.
camp-dependent protein kinase deficiency
cAMP and protein kinase A in endocrine (and other) tumors.
camp-dependent protein kinase deficiency
Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes.
camp-dependent protein kinase deficiency
High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.
camp-dependent protein kinase deficiency
Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production.
Carcinogenesis
Anticarcinogenic effect of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate on 7,12-dimethylbenz(a)anthracene mammary tumor induction in the rat and its relationship to cyclic adenosine 3':5'-monophosphate metabolism and protein kinase.
Carcinogenesis
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.
Carcinogenesis
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Carcinogenesis
Clinical and molecular genetics of Carney complex.
Carcinogenesis
Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine.
Carcinogenesis
Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease.
Carcinogenesis
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Carcinogenesis
Effect of gastrin on gastric mucosal cyclic adenosine 3':5'-monophosphate-dependent protein kinase activity in rat stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis
Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.
Carcinogenesis
Interaction of AIP with protein kinase A (cAMP-dependent protein kinase).
Carcinogenesis
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Carcinogenesis
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.
Carcinogenesis
Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.
Carcinogenesis
Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis.
Carcinogenesis
Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop.
Carcinogenesis
PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.
Carcinogenesis
Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
Carcinogenesis
Second-line therapies in advanced biliary tract cancers.
Carcinogenesis
[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]
Carcinoma
Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma.
Carcinoma
Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter.
Carcinoma
Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.
Carcinoma
Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.
Carcinoma
Cross-activation: overriding cAMP/cGMP selectivities of protein kinases in tissues.
Carcinoma
Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.
Carcinoma
DNAJB1-PRKACA is specific for fibrolamellar carcinoma.
Carcinoma
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Carcinoma
Expression of a mutant regulatory subunit of cAMP-dependent protein kinase in the Caco-2 human colonic carcinoma cell line.
Carcinoma
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Carcinoma
Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss.
Carcinoma
Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.
Carcinoma
Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.
Carcinoma
Redundant regulation of urokinase plasminogen activator transcription by the two major isozymes of cAMP-dependent protein kinase.
Carcinoma
Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.
Carcinoma
Subcellular distribution of the R-subunits of cAMP-dependent protein kinase in LS-174T human colon carcinoma cells.
Carcinoma
The isozyme pattern of cyclic AMP-dependent protein kinase and the distribution of a cervicovaginal antigen in experimental carcinoma of the cervix uteri of mice.
Carcinoma
Two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas.
Carcinoma
Type I and II cyclic adenosine 3':5'-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas.
Carcinoma
Update on the pathology of liver neoplasms.
Carcinoma
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Carcinoma, Ehrlich Tumor
The in vitro effects of glycyrrhizin and the derivatives of glycyrrhetinic acid on the activity of cAMP-dependent protein kinase and phosphorylation of cellular polypeptide by the kinase from Ehrlich ascites tumor cells.
Carcinoma, Embryonal
Effect of retinoic acid treatment of F9 embryonal carcinoma cells on the activity and distribution of cyclic AMP-dependent protein kinase.
Carcinoma, Hepatocellular
Beta-adrenergic receptors and angiotensinogen gene expression in mouse hepatoma cells in vitro.
Carcinoma, Hepatocellular
Cloning and expression in Escherichia coli of a rat hepatoma cell cDNA coding for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Carcinoma, Hepatocellular
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Cytochemical identification of the regulatory subunit of the cAMP-dependent protein kinase by use of fluorescently labeled catalytic subunit. Examination of protein kinase dissociation in hepatoma cells responding to 8-Br-cAMP stimulation.
Carcinoma, Hepatocellular
Direct cytochemical localization of catalytic subunits dissociated from cAMP-dependent protein kinase in Reuber H-35 hepatoma cells. I. Development and validation of fluorescinated inhibitor.
Carcinoma, Hepatocellular
Direct cytochemical localization of catalytic subunits dissociated from cAMP-dependent protein kinase in Reuber H-35 hepatoma cells. II. Temporal and spatial kinetics.
Carcinoma, Hepatocellular
Direct evidence that the protein kinase catalytic subunit mediates the effects of cAMP on tyrosine aminotransferase synthesis.
Carcinoma, Hepatocellular
DNAJB1-PRKACA is specific for fibrolamellar carcinoma.
Carcinoma, Hepatocellular
HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling.
Carcinoma, Hepatocellular
In vivo footprinting of the carbamoylphosphate synthetase I cAMP-response unit indicates important roles for FoxA and PKA in formation of the enhanceosome.
Carcinoma, Hepatocellular
Induction of tyrosine aminotransferase in H-35 hepatoma cells by cAMP captured in phospholipid vesicles.
Carcinoma, Hepatocellular
Inhibition of hepatoma cell growth by analogs of adenosine and cyclic AMP and the influence of enzymes in mammalian sera.
Carcinoma, Hepatocellular
Insulin decreases H4IIE cell PEPCK mRNA by a mechanism that does not involve cAMP.
Carcinoma, Hepatocellular
Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.
Carcinoma, Hepatocellular
Localization of nuclear subunits of cyclic AMP-dependent protein kinase by the immunocolloidal gold method.
Carcinoma, Hepatocellular
Modulation of nuclear cyclic AMP-dependent protein kinase in dibutyryl cyclic AMP-treated rat H4IIE hepatoma cells.
Carcinoma, Hepatocellular
Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.
Carcinoma, Hepatocellular
Phosphorylation of beta-glucuronidases from human normal liver and hepatoma by cAMP-dependent protein kinase.
Carcinoma, Hepatocellular
PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
Carcinoma, Hepatocellular
Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.
Carcinoma, Hepatocellular
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
Carcinoma, Hepatocellular
Structural analyses of the PKA RII? holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Cancer-associated alterations of human hepatocellular carcinoma beta-glucuronidase--study on phosphorylation by 3', 5'-cyclic AMP dependent-protein kinase]
Carcinoma, Hepatocellular
[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]
Carcinoma, Non-Small-Cell Lung
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Carcinoma, Renal Cell
The serine proteinase thrombin promotes migration of human renal carcinoma cells by a PKA-dependent mechanism.
Carcinoma, Squamous Cell
cAMP-dependent protein kinase stimulates epidermal growth factor-dependent phosphorylation of epidermal growth factor receptors.
Carcinoma, Squamous Cell
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Carcinoma, Squamous Cell
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Cardiomegaly
Alterations in activities of cyclic nucleotide systems and in beta-adrenergic receptor-mediated activation of cyclic AMP-dependent protein kinase during progression and regression of isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy.
Cardiomegaly
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.
Cardiomegaly
Effect of endostatin overexpression on angiotensin II-induced cardiac hypertrophy in rats.
Cardiomyopathy, Dilated
Activation of cyclic AMP-dependent protein kinase in cardiomyocytes by anti-beta 1-adrenoceptor autoantibodies from patients with idiopathic dilated cardiomyopathy.
Cardiomyopathy, Dilated
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
Cardiomyopathy, Dilated
Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy.
Cardiomyopathy, Dilated
cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium.
Carney Complex
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Carney Complex
Carney complex review: Genetic features.
Carney Complex
Carney complex: A familial lentiginosis predisposing to a variety of tumors.
Carney Complex
Case report of familial Carney complex due to novel frameshift mutation c.597del C (p.Phe200LeufsX6) in PRKAR1A.
Carney Complex
Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.
Carney Complex
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Carney Complex
Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
Carney Complex
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Carney Complex
GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24.
Carney Complex
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Carney Complex
Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.
Carney Complex
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.
Carney Complex
Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
Carney Complex
PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex.
Carney Complex
Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
Cerebral Infarction
Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice.
Cholangiocarcinoma
FGFR2 genomic aberrations: Achilles heel in the management of advanced cholangiocarcinoma.
Cholera
A crucial role for cAMP and protein kinase A in D1 dopamine receptor regulated intracellular calcium transients.
Cholera
Activation of locus coeruleus (LC) neurones by cholera toxin: mediation by cAMP-dependent protein kinase.
Cholera
Acute and chronic regulation of Na+/K+-ATPase transport activity in the RN22 Schwann cell line in response to stimulation of cyclic AMP production.
Cholera
Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase activity in rodent pituitary tissue: possible role in cAMP-dependent hormone secretion.
Cholera
Calcium-mediated transduction of the hormonal message in meiosis reinitiation of starfish oocytes: modulation following injection of cholera toxin and cAMP-dependent protein kinase.
Cholera
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Cholera
Cholera toxin induces cAMP-independent degradation of Gs.
Cholera
Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells.
Cholera
Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling.
Cholera
Differential effects of activation of protein kinase C and cyclic-AMP-dependent protein kinase on sodium-dependent phosphate uptake in NIH 3T3 cells.
Cholera
Effect of ADP-ribosylation factor amino-terminal deletions on its GTP-dependent stimulation of cholera toxin activity.
Cholera
Effects of cholera toxin on thyroid cyclic AMP-dependent protein kinase and ornithine decarboxylase activities.
Cholera
Effects of cholinergic and adrenergic agonists on phosphorylation of a 165,000-dalton myofibrillar protein in intact cardiac muscle.
Cholera
Epidermal growth factor modulates cholera toxin induced mammary gland development.
Cholera
Evidence of heterotrimeric G-protein involvement in regulated exocytosis from permeabilized pancreatic acini.
Cholera
Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.
Cholera
Influence of cholera toxin (an adenylate cyclase activator) on deoxyribonucleic acid synthesis of bovine mammary tissue in vitro and in athymic nude mice.
Cholera
Inhibition by the protein kinase inhibitors, isoquinolinesulfonamides, of fluid accumulation induced by Escherichia coli heat-stable enterotoxin, 8-bromo-cGMP and 8-bromo-cAMP in suckling mice.
Cholera
Inhibition of choriogonadotropin-activated steroidogenesis in cultured Leydig tumor cells by the Rp diastereoisomer of adenosine 3',5'-cyclic phosphorothioate.
Cholera
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.
Cholera
Modification of steroidogenesis in a mouse adrenal cell line (Y-1) transformed by simian adenovirus SA-7.
Cholera
Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts.
Cholera
Regulation of CTP:phosphocholine cytidylyltransferase activity and phosphorylation in rat hepatocytes: lack of effect of elevated cAMP levels.
Cholera
Regulation of S49 lymphoma cell growth by cyclic adenosine 3':5'-monophosphate.
Cholera
Relationship of phosphorylation and ADP-ribosylation using a synthetic peptide as a model substrate.
Cholera
Stimulation of chick adrenal steroidogenesis by avian parathyroid hormone.
Cholera
The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage.
Cholera
The effect of cyclic nucleotides and cholera toxin on in vivo and in vitro phosphorylation of small intestinal brush border membranes.
Cholera
The pure inhibitor of cAMP-dependent protein kinase initiates Xenopus laevis meiotic maturation. A 4-step scheme for meiotic maturation.
Cholera
The regulation of steroidogenesis is different in the two types of ovine luteal cells.
Cholera
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Cholera
[Modulation of calcium conductance of the somatic membrane of sensory neurons of the rat upon activation of the adenylate cyclase system]
Chondroma
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Chondrosarcoma
Phosphorylation of proteoglycans from human articular cartilage by a cAMP-dependent protein kinase.
Choriocarcinoma
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Colonic Neoplasms
Adenosine 3',5'-cyclic monophosphate dependent and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer.
Colonic Neoplasms
Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer.
Colonic Neoplasms
Synergistic growth inhibition and induction of apoptosis by a novel mixed backbone antisense oligonucleotide targeting CRIPTO in combination with C225 anti-EGFR monoclonal antibody and 8-Cl-cAMP in human GEO colon cancer cells.
Colorectal Neoplasms
Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.
Colorectal Neoplasms
[Expression of cAMP-dependent protein kinase inhibitor beta in colorectal carcinoma and its clinical significance].
Craniocerebral Trauma
[The cAMP content and cAMP-dependent protein kinase activity in the brain of rabbits in the dynamics of moderate craniocerebral trauma]
Cryopyrin-Associated Periodic Syndromes
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
Cushing Syndrome
A genetic and molecular update on adrenocortical causes of Cushing syndrome.
Cushing Syndrome
Activating Hotspot L205R Mutation in PRKACA and Adrenal Cushing's Syndrome.
Cushing Syndrome
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Cushing Syndrome
cAMP signaling in cortisol-producing adrenal adenoma.
Cushing Syndrome
Carney complex: an update.
Cushing Syndrome
Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.
Cushing Syndrome
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Cushing Syndrome
Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.
Cushing Syndrome
Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.
Cushing Syndrome
Germline PRKACA amplification leads to Cushing syndrome caused by 3 adrenocortical pathologic phenotypes.
Cushing Syndrome
Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.
Cushing Syndrome
Mechanisms of Aberrant PKA Activation by C? Subunit Mutations.
Cushing Syndrome
Neuroendocrine cancer. An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics.
Cushing Syndrome
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Cushing Syndrome
PKA C? subunit mutation triggers caspase-dependent RII? subunit degradation via Ser114 phosphorylation.
Cushing Syndrome
Protein kinase A defects and cortisol-producing adrenal tumors.
Cushing Syndrome
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
Cushing Syndrome
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
Cushing Syndrome
Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.
Cystic Fibrosis
A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification.
Cystic Fibrosis
A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules.
Cystic Fibrosis
Abnormal subcellular localization of mutated CFTR protein in a cystic fibrosis epithelial cell line.
Cystic Fibrosis
Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells.
Cystic Fibrosis
Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents.
Cystic Fibrosis
Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity.
Cystic Fibrosis
cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation.
Cystic Fibrosis
cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions.
Cystic Fibrosis
Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter.
Cystic Fibrosis
Contribution of R domain phosphoserines to the function of CFTR studied in Fischer rat thyroid epithelia.
Cystic Fibrosis
Correction: cAMP/Protein Kinase A Activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP Release from Rat Skeletal Muscle during Low pH or Contractions.
Cystic Fibrosis
Cyclic AMP-dependent protein kinase activation of cystic fibrosis transmembrane conductance regulator chloride channels in planar lipid bilayers.
Cystic Fibrosis
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium.
Cystic Fibrosis
Cyclic AMP-related and cation-affected human platelet chloride transport regulation.
Cystic Fibrosis
Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation.
Cystic Fibrosis
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Cystic Fibrosis
Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines.
Cystic Fibrosis
Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.
Cystic Fibrosis
Fatty acids inhibit apical membrane chloride channels in airway epithelia.
Cystic Fibrosis
Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel.
Cystic Fibrosis
Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells.
Cystic Fibrosis
Multiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Mutation of potential phosphorylation sites in the recombinant R domain of the cystic fibrosis transmembrane conductance regulator has significant effects on domain conformation.
Cystic Fibrosis
Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis.
Cystic Fibrosis
Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein.
Cystic Fibrosis
Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.
Cystic Fibrosis
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.
Cystic Fibrosis
Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin.
Cystic Fibrosis
Regulation of CFTR Trafficking by Its R Domain.
Cystic Fibrosis
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
Cystic Fibrosis
Syntaxin 1A inhibits regulated CFTR trafficking in xenopus oocytes.
Cystic Fibrosis
The formation of the cAMP/protein kinase A-dependent annexin 2 S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function.
Cystic Fibrosis
Type II protein kinase A regulates CFTR in airway, pancreatic, and intestinal cells.
Cysticercosis
Immunodiagnosis of porcine cysticercosis: identification of candidate antigens through immunoproteomics.
Cysticercosis
TsPKA-r: a potential immunodiagnostic antigen for the detection of porcine cysticercosis.
Cysts
Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.
Cysts
The Effect of cAMP-PKA Activation on TGF-?1-Induced Profibrotic Signaling.
Dehydration
Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs.
Dehydration
Stimulation of CFU-f formation by prostaglandin E(2) is mediated in part by its degradation product, prostaglandin A(2).
Dehydration
Stimulation of CFU-f formation by prostaglandin E2 is mediated in part by its degradation product, prostaglandin A2.
Dehydration
[Activity of cAMP-dependent protein kinases and cAMP-binding proteins from rat renal cytosol upon dehydration.]
Dermatitis, Exfoliative
A cAMP binding abnormality in psoriasis.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Diabetic Cardiomyopathies
Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats.
Dyskinesias
Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism.
Fibrosarcoma
?2-Adrenoceptor Agonists Promote ERK1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-driven Signaling Independently of ?-Arrestin 2.
Focal Nodular Hyperplasia
Update on the pathology of liver neoplasms.
Glaucoma
Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma.
Glioblastoma
Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line.
Glioblastoma
Proteomic studies on low- and high-grade human brain astrocytomas.
Glioblastoma
The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.
Glioma
beta Adrenergic receptor-mediated regulation of cyclic nucleotide phosphodiesterase in C6 glioma cells: vinblastine blockade of isoproterenol induction.
Glioma
Characterization of cyclic adenosine 3':5'-monophosphate-dependent protein kinase isozymes in normal and neoplastic fetal rat brain cells.
Glioma
Differential effects of two structurally related N6-substituted cAMP analogues on C6 glioma cells.
Glioma
External cyclic AMP-dependent protein kinase activity in rat C-6 glioma cells.
Glioma
Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner.
Glioma
MicroRNA 335 Is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP/Protein Kinase A Pathway.
Glioma
Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.
Glioma
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Glioma
Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma X glioma hybrid cells.
Glioma
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
Glioma
Selective distribution of protein kinase A regulatory subunit RII{alpha} in rodent gliomas.
Glioma
The role of protein kinase C in cellular tolerance to ethanol.
Glioma
The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells.
Glioma
Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas.
Goiter
Properties of cyclic AMP-dependent protein kinase in normal and goitrous rat thyroid gland.
Goiter
TSH and DBC action on cAMP-dependent protein kinase activities in cell cultures of human non-toxic goiters.
Gray Platelet Syndrome
Abnormal cAMP-induced phosphorylation of rap 1 protein in grey platelet syndrome platelets.
Growth Hormone-Secreting Pituitary Adenoma
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Heart Arrest
Cyclic adenosine monophosphate-protein kinase A signal pathway may be involved in pulmonary aquaporin-5 expression in ischemia/reperfusion rats following deep hypothermia cardiac arrest.
Heart Failure
cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium.
Heart Failure
cAMP-dependent protein kinase A-stimulated sarcoplasmic reticulum function in heart failure.
Heart Failure
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Heart Failure
Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach.
Heart Failure
Signalling pathways in cardiac failure.
Hepatitis C
Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit.
Hepatitis C
Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.
Hepatitis C
Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.
Hepatitis C
Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase.
Hepatitis C
The inhibition of cAMP-dependent protein kinase by full-length hepatitis C virus NS3/4A complex is due to ATP hydrolysis.
Hepatoblastoma
Cold-stimulated increase in a regulatory subunit of cAMP-dependent protein kinase in human hepatoblastoma cells.
Herpes Simplex
Expression of the cyclic AMP-dependent protein kinase (PKA) catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF.
Herpes Simplex
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
Herpes Zoster
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Herpes Zoster
N6-substituted cAMP Analogs Inhibit bTREK-1 K+ Channels and Stimulate Cortisol Secretion by a PKA-Independent Mechanism.
HIV Infections
Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART.
HIV Infections
Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP.
HIV Infections
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients.
Hyperaldosteronism
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.
Hyperalgesia
cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.
Hyperalgesia
cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain.
Hyperalgesia
Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.
Hyperalgesia
Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.
Hyperalgesia
Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors.
Hyperalgesia
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Hyperalgesia
Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia.
Hyperalgesia
Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization.
Hyperalgesia
Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo.
Hyperglycemia
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
Hyperhomocysteinemia
Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.
Hyperpigmentation
cAMP-dependent PKA activation as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide.
Hypersensitivity
Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
Hypersensitivity
Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.
Hypersensitivity
Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.
Hypertension
Analysis of Genes Related to Angiotensin II-Induced Arterial Injury Using a Time Series Microarray.
Hypertension
Selective effect of high arterial pressure in hypertension upon inhibition of cGMP versus cAMP mediated vascular relaxation.
Hyperthyroidism
Cyclic AMP-dependent protein kinase activation in hearts from euthyroid and hyperthyroid rats.
Hyperthyroidism
Hyperthyroidism affects the activity of a cAMP-dependent protein kinase and protein phosphorylation in heart sarcolemma.
Hyperthyroidism
The effect of thyroxine on the calmodulin-dependent (Ca2+-Mg2+)ATPase activity and protein phosphorylation in rabbit fast skeletal muscle sarcolemma.
Hypertrophy, Left Ventricular
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.
Hypoglycemia
Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study.
Hypophosphatemia, Familial
Cyclic AMP-dependent protein phosphorylation in canine renal brush-border membrane vesicles is associated with decreased phosphate transport.
Infections
A putative PKA phosphorylation site S227 in MoSom1 is essential for infection-related morphogenesis and pathogenicity in Magnaporthe oryzae.
Infections
An expanded subfamily of G-protein-coupled receptor genes in Fusarium graminearum required for wheat infection.
Infections
Complementation of the Magnaporthe grisea deltacpkA mutation by the Blumeria graminis PKA-c gene: functional genetic analysis of an obligate plant pathogen.
Infections
Coxiella burnetii Exploits Host cAMP-Dependent Protein Kinase Signaling to Promote Macrophage Survival.
Infections
Effects of beta-agonists on airway epithelial cells.
Infections
Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation.
Infections
Increased mitogen-activated protein kinase activity and TNF-alpha production associated with Mycobacterium smegmatis- but not Mycobacterium avium-infected macrophages requires prolonged stimulation of the calmodulin/calmodulin kinase and cyclic AMP/protein kinase A pathways.
Infections
Induction of a cytosolic pyruvate kinase 1 gene during the resistance response to Tobacco mosaic virus in Capsicum annuum.
Infections
Oxidant activated soluble adenylate cyclase of Leishmania donovani regulates the cAMP-PKA signaling axis for its intra-macrophage survival during infection.
Infections
PKA and Apicomplexan Parasite Diseases.
Infections
Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.
Infections
Signal transduction pathways and apoptosis in bacteria infected chondrocytes.
Infections
The cAMP signaling pathway in Fusarium verticillioides is important for conidiation, plant infection, and stress responses but not fumonisin production.
Infections
The cAMP-PKA pathway regulates growth, sexual and asexual differentiation, and pathogenesis in Fusarium graminearum.
Infections
The cyclase-associated protein FgCap1 has both protein kinase A-dependent and -independent functions during deoxynivalenol production and plant infection in Fusarium graminearum.
Infections
The gene fpk1, encoding a cAMP-dependent protein kinase catalytic subunit homolog, is required for hyphal growth, spore germination, and plant infection in Fusarium verticillioides.
Infections
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.
Infections
Two novel transcriptional regulators are essential for infection-related morphogenesis and pathogenicity of the rice blast fungus Magnaporthe oryzae.
Infections
Virus-induced atherosclerosis. Herpesvirus infection alters aortic cholesterol metabolism and accumulation.
Infertility
Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men.
Insulin Resistance
Cilostazol ameliorates metabolic abnormalities with suppression of proinflammatory markers in a db/db mouse model of type 2 diabetes via activation of peroxisome proliferator-activated receptor gamma transcription.
Insulin Resistance
Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis.
Insulin Resistance
Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.
Insulinoma
Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic beta-Cells.
Intellectual Disability
Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.
Intestinal Volvulus
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.
Intestinal Volvulus
Isolation and characterization of the regulatory subunit of cAMP-dependent protein kinase from the filarial parasite Onchocerca volvulus.
Intestinal Volvulus
Phosphoprotein patterns in Onchocerca volvulus developmental stages.
Irritable Bowel Syndrome
Aquaporins 1, 3 and 8 expression and cytokines in irritable bowel syndrome rats' colon via cAMP-PKA pathway.
Ischemic Attack, Transient
Changes of [3H]cyclic adenosine monophosphate binding in the gerbil brain following transient cerebral ischemia: an autoradiographic study and investigation of the effects of vinconate and pentobarbital.
Ischemic Attack, Transient
Sequential alterations of [3H]rolipram and [3H]cyclic adenosine monophosphate binding in the gerbil brain following transient cerebral ischemia.
Kidney Failure, Chronic
Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.
Leiomyoma
Human uterine smooth muscle and leiomyoma cells differ in their rapid 17beta-estradiol signaling: implications for proliferation.
Lentigo
Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.
Leukemia
8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells.
Leukemia
Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.
Leukemia
Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.
Leukemia
Circumvention of multidrug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87.
Leukemia
Cooperative interactions of protein kinase C and cAMP-dependent protein kinase systems in human promyelocytic leukemia HL60 cells.
Leukemia
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
Leukemia
Protein kinase C phosphorylates leukemia RNA polymerase II.
Leukemia
Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.
Leukemia
Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities.
Leukemia
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Leukemia
Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells.
Leukemia, Erythroblastic, Acute
cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation.
Leukemia, Erythroblastic, Acute
Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes.
Leukemia, Erythroblastic, Acute
Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation
Leukemia, Erythroblastic, Acute
Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation.
Leukemia, Erythroblastic, Acute
Impaired erythroid-specific gene expression in cAMP-dependent protein kinase-deficient murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Protein kinase activity, growth and differentiation of murine erythroleukemia cells.
Leukemia, Myeloid
Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.
Leukemia, Myeloid
Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells.
Leukemia, Myeloid
Regulation of jun-B expression by a cyclic AMP (cAMP)-dependent mechanism in human myeloid cells.
Leukemia, Myeloid
Retinoylation of vimentin in the human myeloid leukemia cell line HL60.
Leukemia, Myeloid
Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis.
Leukemia, Promyelocytic, Acute
Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.
Leukemia, Promyelocytic, Acute
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Leukemia, Promyelocytic, Acute
Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells.
Liver Diseases
Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice.
Liver Neoplasms
Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.
Lordosis
In the ventral tegmental area, progestins' membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A.
Lordosis
Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.
Lung Neoplasms
cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells.
Lung Neoplasms
Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer.
Lung Neoplasms
Selective activation of cyclic AMP dependent protein kinase by calcitonin in a calcitonin secreting lung cancer cell line.
Lung Neoplasms
[Experimental study of effects of nm23-H1 gene transfection on the change of PKA activity in human high-metastasis large cell lung cancer cell line L9981.]
Lung Neoplasms
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Lung Neoplasms
[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]
Lupus Erythematosus, Systemic
Association of deficient type II protein kinase A activity with aberrant nuclear translocation of the RII beta subunit in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.
Lupus Erythematosus, Systemic
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
mRNA mutations of type I protein kinase A regulatory subunit alpha in T lymphocytes of a subject with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells.
Lupus Erythematosus, Systemic
Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production.
Lymphoma
A kinase-negative mutant of S49 mouse lymphoma cells is defective in posttranslational maturation of catalytic subunit of cyclic AMP-dependent protein kinase.
Lymphoma
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells.
Lymphoma
A variant of S49 mouse lymphoma cells with enhanced secretion of cyclic AMP.
Lymphoma
Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.
Lymphoma
Activation of type I cyclic AMP-dependent protein kinases with defective cyclic AMP-binding sites.
Lymphoma
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Lymphoma
Analysis of the dominance of mutations in cAMP-binding sites of murine type I cAMP-dependent protein kinase in activation of kinase from heterozygous mutant lymphoma cells.
Lymphoma
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
Lymphoma
Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.
Lymphoma
Cholera toxin induces cAMP-independent degradation of Gs.
Lymphoma
Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in murine T-lymphoma cells.
Lymphoma
Cyclic AMP-resistant mutants of S49 mouse lymphoma cells hemizygous for expression of regulatory subunit of type I cyclic AMP-dependent protein kinase.
Lymphoma
Fine-structure mapping of charge-shift mutations in regulatory subunit of type I cyclic AMP-dependent protein kinase.
Lymphoma
Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells.
Lymphoma
HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism.
Lymphoma
Homology between regulatory subunits of type 1 cyclic AMP-dependent protein kinases from bovine and murine cells.
Lymphoma
Hotspots for spontaneous and mutagen-induced lesions in regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells.
Lymphoma
Interactions between cyclic AMP- and phorbol ester-dependent phosphorylation systems in S49 mouse lymphoma cells.
Lymphoma
Kinase-negative mutants of S49 mouse lymphoma cells carry a trans-dominant mutation affecting expression of cAMP-dependent protein kinase.
Lymphoma
Linked spontaneous CG----TA mutations at CpG sites in the gene for protein kinase regulatory subunit.
Lymphoma
Mouse lymphoma cells with mutations of cyclic AMP-dependent protein kinase.
Lymphoma
Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells.
Lymphoma
Mutations that alter the charge of type I regulatory subunit and modify activation properties of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells.
Lymphoma
Pathways for degradation of the catalytic subunit of cAMP-dependent protein kinase differ in wild-type and kinase-negative S49 mouse lymphoma cells.
Lymphoma
Phorbol ester-mediated protein phosphorylations in S49 mouse lymphoma cells.
Lymphoma
Phosphorylation of regulatory subunit of type I cyclic AMP-dependent protein kinase: biphasic effects of cyclic AMP in intact S49 mouse lymphoma cells.
Lymphoma
Revertants of a trans-dominant S49 mouse lymphoma mutant that affects expression of cAMP-dependent protein kinase.
Lymphoma
Second-site mutations in cyclic AMP-sensitive revertants of a Ka mutant of S49 mouse lymphoma cells reduce the affinity of regulatory subunit of cyclic AMP-dependent protein kinase for catalytic subunit.
Lymphoma
Sites of phosphorylation and mutation in regulatory subunit of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells: mapping to structural domains.
Lymphoma
Spectrum of spontaneous missense mutations causing cyclic AMP-resistance phenotypes in cultured S49 mouse lymphoma cells differs markedly from those of mutations induced by alkylating mutagens.
Lymphoma
Studies on the phosphorylation and synthesis of type I regulatory subunit of cyclic AMP-dependent protein kinase in intact S49 mouse lymphoma cells.
Lymphoma
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
Lymphoma
The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.
Lymphoma
The S49 Kin- cell line transcribes and translates a functional mRNA coding for the catalytic subunit of cAMP-dependent protein kinase.
Lymphoma
Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP.
Malaria
Expression and biochemical characterization of the Plasmodium falciparum protein kinase A catalytic subunit.
Malaria
The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes.
Malnutrition
Activity of cAMP-dependent protein kinase is reduced in protein-energy malnourished rats.
Mastocytoma
Cyclic AMP, nuclear protein kinase and the PY815 cell cycle.
Mastocytoma
Mammalian histidine decarboxylase: effect by protein kinase on mouse mastocytoma histidine decarboxylase.
Melanoma
Activation of cAMP-dependent protein kinase is required for optimal alpha-melanocyte-stimulating hormone-induced pigmentation.
Melanoma
Activation of melanoma tyrosinase by a cyclic AMP-dependent protein kinase in a cell-free system.
Melanoma
Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.
Melanoma
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Melanoma
Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas.
Melanoma
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Melanoma
Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture.
Melanoma
Evidence suggesting that a cyclic AMP-dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells.
Melanoma
Extracellular cAMP-dependent protein kinase (ECPKA) in melanoma.
Melanoma
Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells.
Melanoma
Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.
Melanoma
Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and phosphatidylinositol 3-kinase pathways.
Melanoma
Retinoic acid increases cyclic AMP-dependent protein kinase activity in murine melanoma cells.
Melanoma
Suppression of cyclic AMP-dependent protein kinase activity in murine melanoma cells by 12-0-tetradecanoylphorbol-13-acetate.
Melanoma
The effect of retinoic acid on protein phosphorylation in mouse melanoma cells.
Melanoma, Experimental
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Melanoma, Experimental
Evidence suggesting that a cyclic AMP-dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells.
Melanoma, Experimental
Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.
Melanoma, Experimental
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.
Memory Disorders
Altered autophosphorylation of adenosine 3',5'-phosphate-dependent protein kinase in the dunce memory mutant of Drosophila melanogaster.
Meningitis
The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis.
Murine Acquired Immunodeficiency Syndrome
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.
Mycoses
cAMP-pKA signaling regulates multiple steps of fungal infection cooperatively with Cmk1 MAP kinase in Colletotrichum lagenarium.
Myeloproliferative Disorders
Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia.
Myocardial Infarction
Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction.
Myocardial Infarction
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.
Myocardial Infarction
microRNA-208a in an early stage myocardial infarction rat model and the effect on cAMP-PKA signaling pathway.
Myocardial Infarction
[cAMP-dependent phosphorylation of myocardial troponin in experimental myocardial infarction]
Myocarditis
The increase in viscosity and peroxidation of sarcoplasmic reticulum membrane lipids in isadrine myocarditis.
Myocarditis
[Effect of the catalytic subunit of cAMP-dependent protein kinase on the electrical activity of the rat heart in isadrine myocarditis]
Myotonic Dystrophy
Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.
Myotonic Dystrophy
Unstable DNA may be responsible for the incomplete penetrance of the myotonic dystrophy phenotype.
Myxoma
Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.
Myxoma
Carney complex: an update.
Myxoma
Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.
Myxoma
Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.
Myxoma
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Neoplasm Metastasis
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
Neoplasm Metastasis
GPER-regulated lncRNA-Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple-negative breast cancer.
Neoplasm Metastasis
Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and phosphatidylinositol 3-kinase pathways.
Neoplasm Metastasis
PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
Neoplasm Metastasis
[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]
Neoplasms
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells.
Neoplasms
8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.
Neoplasms
8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer.
Neoplasms
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
Neoplasms
A safety and pharmacokinetic study of a mixed-backbone oligonucleotide (GEM231) targeting the type I protein kinase A by two-hour infusions in patients with refractory solid tumors.
Neoplasms
A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth.
Neoplasms
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Neoplasms
Activation of cyclic AMP-dependent protein kinase activity during LPS stimulation of macrophage tumor cell line, J774.1.
Neoplasms
Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase activity in rodent pituitary tissue: possible role in cAMP-dependent hormone secretion.
Neoplasms
Adenosine 3'5'-cyclic monophosphate dependent protein kinase in human adrenocortical tumors.
Neoplasms
Adjacent sequence controls the response polarity of nitric oxide-sensitive Sp factor binding sites.
Neoplasms
Adrenocortical tumorigenesis: Lessons from genetics.
Neoplasms
Alterations in the cAMP signal transduction pathway in mouse lung tumorigenesis.
Neoplasms
Alterations of protein kinase isozymes in transplantable human lung cancer with special reference to the phosphorylation of arylsulfatase B.
Neoplasms
Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors.
Neoplasms
Altered cyclic AMP-dependent protein kinase activity in a mutant adrenocortical tumor cell line.
Neoplasms
An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.
Neoplasms
An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.
Neoplasms
AniScan Using Extracellular Cyclic AMP-Dependent Protein Kinase A as a Serum Biomarker Assay for the Diagnosis of Malignant Tumors in Dogs.
Neoplasms
Anti-Alzheimer's Disease Molecular Mechanism of Acori Tatarinowii Rhizoma Based on Network Pharmacology.
Neoplasms
Anticarcinogenic effect of retinoids on 7,12-dimethylbenz(a)anthracene-induced mammary tumor induction, and its relationship to cyclic AMP-dependent protein kinase.
Neoplasms
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Neoplasms
Antisense DNA toward type I protein kinase A produces sustained inhibition of tumor growth.
Neoplasms
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.
Neoplasms
Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.
Neoplasms
Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy.
Neoplasms
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Neoplasms
Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration.
Neoplasms
Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide.
Neoplasms
Appearance of 50,000- and 52,000-dalton cAMP receptor proteins in the nucleoli of regressing MCF-7 human breast cancer upon estrogen withdrawal.
Neoplasms
Autoantibody cancer biomarker: extracellular protein kinase a.
Neoplasms
BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
Neoplasms
Beta 2-adrenergic receptor regulation after transfection into a cell line deficient in the cAMP-dependent protein kinase.
Neoplasms
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Neoplasms
Biochemical characterization of extracellular cAMP-dependent protein kinase as a tumor marker.
Neoplasms
Biochemical parameters in the anterior pituitary during the course of tumorigenesis induced by diethylstilbestrol treatment.
Neoplasms
cAMP and protein kinase A in endocrine (and other) tumors.
Neoplasms
cAMP-dependent protein kinase activation inhibits proliferation and enhances apoptotic effect of tumor necrosis factor-alpha in NCI-H295R adrenocortical cells.
Neoplasms
cAMP-dependent protein kinase II interactions with nuclei derived from rat mammary tumor.
Neoplasms
cAMP-independent protein kinase activity is correlated with growth of rat mammary tumors.
Neoplasms
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Neoplasms
cAMP-PKA inhibition of SK3 channel reduced both Ca(2+) entry and cancer cell migration by regulation of SK3-Orai1 complex.
Neoplasms
Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.
Neoplasms
Carney complex: an update.
Neoplasms
Cellular localization and age-dependent changes in mRNA for cyclic adenosine 3',5'-monophosphate-dependent protein kinases in rat testis.
Neoplasms
Changes in cyclic adenosine monophosphate-responsive element binding proteins in rat hepatomas.
Neoplasms
Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.
Neoplasms
Characteristics of extracellular cyclic AMP-dependent protein kinase as a biomarker of cancer in dogs.
Neoplasms
Characterization of cell surface adenosine 3',5'-monophosphate-binding proteins in Y-1 mouse adrenal tumor cells.
Neoplasms
Characterization of the cyclic adenosine 3':5'-monophosphate effector system in hormone-dependent and hormone-independent rat mammary carcinomas.
Neoplasms
Characterization of the morphological, growth, and steroidogenic effect of TPA on mouse Y-1 adrenal cortical tumor cells in culture.
Neoplasms
Chemoprevention with Protein Kinase A RI{alpha} Antisense in DMBA-Mammary Carcinogenesis.
Neoplasms
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma.
Neoplasms
Cisplatin resistance in cyclic AMP-dependent protein kinase mutants.
Neoplasms
Clinical and molecular genetics of Carney complex.
Neoplasms
Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I.
Neoplasms
Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.
Neoplasms
Complex roles of cAMP-PKA-CREB signaling in cancer.
Neoplasms
Constitutive levels of cAMP-dependent protein kinase activity determine sensitivity of human multidrug-resistant leukaemic cell lines to growth inhibition and apoptosis by forskolin and tumour necrosis factor alpha.
Neoplasms
Cooperative antiproliferative effects of 8-chloro-cyclic AMP and 528 anti-epidermal growth factor receptor monoclonal antibody on human cancer cells.
Neoplasms
Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth.
Neoplasms
Correlation of estrogen receptors and charge alterations of regulatory subunits of cAMP-dependent protein kinases in human mammary tumor cells.
Neoplasms
Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.
Neoplasms
Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine.
Neoplasms
CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy.
Neoplasms
Cyclic adenosine 3':5-monophosphate receptor proteins in hormone-dependent and -independent rat mammary tumors.
Neoplasms
Cyclic AMP and tumor promoters cause differential induction of ornithine decarboxylase and accumulation of putrescine in Chinese hamster ovary cells deficient in cyclic AMP-dependent protein kinase.
Neoplasms
Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.
Neoplasms
Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells.
Neoplasms
Cyclic AMP-dependent protein kinase type I and type II and cyclic AMP binding in human mammary tumors.
Neoplasms
Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.
Neoplasms
Cyclic AMP-dependent protein kinase-mediated desensitisation of adrenal tumour cells.
Neoplasms
Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury.
Neoplasms
Cytotoxic activity of effector T cells against cholangiocarcinoma is enhanced by self-differentiated monocyte-derived dendritic cells.
Neoplasms
Decreased adenylyl cyclase and cAMP-dependent protein kinase activities inhibit the cytotoxic function of human natural killer cells.
Neoplasms
Decreased expression of the type I isozyme of cAMP-dependent protein kinase in tumor cell lines of lung epithelial origin.
Neoplasms
Dibutyryl cyclic AMP mimics ovariectomy: nuclear protein phosphorylation in mammary tumor regression.
Neoplasms
Differential effects of dibutyryl cyclic adenosine monophosphate and retinoic acid on the growth, differentiation, and cyclic adenosine monophosphate-binding protein of murine neuroblastoma cells.
Neoplasms
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
Neoplasms
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Neoplasms
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
Neoplasms
Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
Neoplasms
Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.
Neoplasms
DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.
Neoplasms
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
Neoplasms
Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.
Neoplasms
Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein.
Neoplasms
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase.
Neoplasms
Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas.
Neoplasms
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
Neoplasms
Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin.
Neoplasms
Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice.
Neoplasms
ENDOCRINE TUMOURS: The genomics of adrenocortical tumors.
Neoplasms
Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.
Neoplasms
Enhanced casein kinase II activity in human tumour cell cultures.
Neoplasms
Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation.
Neoplasms
Extracellular activity of cyclic AMP-dependent protein kinase as a biomarker for human cancer detection: distribution characteristics in a normal population and cancer patients.
Neoplasms
Extracellular cAMP-dependent protein kinase (ECPKA) in melanoma.
Neoplasms
Fructose 2,6-bisphosphate metabolism in Ehrlich ascites tumour cells.
Neoplasms
Ganoderma atrum polysaccharide evokes antitumor activity via cAMP-PKA mediated apoptotic pathway and down-regulation of Ca(2+)/PKC signal pathway.
Neoplasms
Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.
Neoplasms
Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.
Neoplasms
Genomic analysis of fibrolamellar hepatocellular carcinoma.
Neoplasms
Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.
Neoplasms
Genomic insights into Cushing syndrome.
Neoplasms
Genomics of benign adrenocortical tumors.
Neoplasms
Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells.
Neoplasms
Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: Involvement of cAMP-PKA and MAPK pathways.
Neoplasms
Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action.
Neoplasms
Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.
Neoplasms
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Neoplasms
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Neoplasms
Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-?B/AMP-activated kinase/myosin light chain kinase pathway.
Neoplasms
Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm.
Neoplasms
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.
Neoplasms
Importance of adrenergic pathways in women's cancers.
Neoplasms
Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.
Neoplasms
Increase of cyclic AMP-dependent protein kinase type II as an early event in hormone-dependent mammary tumor regression.
Neoplasms
Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer.
Neoplasms
Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.
Neoplasms
Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate.
Neoplasms
Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.
Neoplasms
Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.
Neoplasms
Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.
Neoplasms
Involvement of IGF-I signaling pathway in the regulation of steroidogenesis in mouse Leydig cells treated with fenvalerate.
Neoplasms
Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells.
Neoplasms
Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
Neoplasms
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
Neoplasms
Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.
Neoplasms
Membranal tyrosine protein kinase activity (but not cAMP-dependent protein kinase activity) is associated with growth of rat mammary tumors.
Neoplasms
Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells.
Neoplasms
Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors.
Neoplasms
Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.
Neoplasms
Molecular mechanisms of corticotropin-releasing factor stimulation of calcium mobilization and adrenocorticotropin release from anterior pituitary tumor cells.
Neoplasms
mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).
Neoplasms
Neuroendocrine cancer. An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics.
Neoplasms
Nuclear protein kinase substrates in AtT-20 cells: translocation of a 14 kDa phosphoprotein.
Neoplasms
Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells.
Neoplasms
Parathyroid hormone modulates protein kinase in giant cell tumors of human bone.
Neoplasms
Partial purification and characterization of the defective cyclic adenosine 3':5'-monophosphate binding protein kinase from adrenocortical carcinoma.
Neoplasms
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Neoplasms
Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.
Neoplasms
Phorbol ester-mediated protein phosphorylations in S49 mouse lymphoma cells.
Neoplasms
Phosphorylation of human lysosomal arylsulfatase B by cAMP-dependent protein kinase. Different sites of phosphorylation between normal and cancer tissues.
Neoplasms
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Neoplasms
Phosphorylation of three proteins in the plasma membrane of Y-1 adrenal cells by a membrane-bound adenosine 3',5'-monophosphate-dependent protein kinase.
Neoplasms
PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.
Neoplasms
PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia - a single-center study of 60 cases.
Neoplasms
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.
Neoplasms
PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.
Neoplasms
Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
Neoplasms
Properties of p19, a novel cAMP-dependent protein kinase substrate protein purified from bovine brain.
Neoplasms
Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I.
Neoplasms
Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling.
Neoplasms
Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.
Neoplasms
Protective vascular and myocardial effects of adiponectin.
Neoplasms
Protein kinase A as target for novel integrated strategies of cancer therapy.
Neoplasms
Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages.
Neoplasms
Protein kinase A defects and cortisol-producing adrenal tumors.
Neoplasms
Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
Neoplasms
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
Neoplasms
Protein kinase A-directed antisense restrains cancer growth: sequence-specific inhibition of gene expression.
Neoplasms
Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway.
Neoplasms
Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
Neoplasms
Protein phosphorylation in normal and neoplastic development. Cyclic AMP-dependent protein kinase activity in urethane-induced pulmonary tumours.
Neoplasms
Protein phosphorylation of human lysosomal arylsulfatase B from normal and cancer tissues.
Neoplasms
Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytes.
Neoplasms
PTHrP, its receptor, and protein kinase A activation in osteosarcoma.
Neoplasms
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
Neoplasms
Recovery of hormonal regulation in protein kinase defective adrenal cells through DNA-mediated gene transfer.
Neoplasms
Recovery of responsiveness to ACTH and cAMP in a protein kinase-defective adrenal cell mutant following transfection with a protein kinase gene.
Neoplasms
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.
Neoplasms
Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.
Neoplasms
Reduced gonadotropin responses in a novel clonal strain of Leydig tumor cells established by transfection of MA-10 cells with a mutant gene of the type I regulatory subunit of the cAMP-dependent protein kinase.
Neoplasms
Regression of hormone-dependent mammary tumors in Sprague-Dawley rats as a result of tamoxifen or pharmacologic doses of 17 beta-estradiol: cyclic adenosine 3',5'-monophosphate-mediated events.
Neoplasms
Regulation of ornithine decarboxylase activity by corticotropin in adrenocortical tumor cell clones: roles of cyclic AMP and cyclic AMP-dependent protein kinase.
Neoplasms
Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
Neoplasms
Release of lipoprotein lipase from Ehrlich ascites tumor produced by an association with a rapid increase in cyclic AMP content.
Neoplasms
Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A.
Neoplasms
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
Neoplasms
Rolipram, salbutamol and prostaglandin E2 suppress TNFalpha release from human monocytes by activating Type II cAMP-dependent protein kinase.
Neoplasms
Second-line therapies in advanced biliary tract cancers.
Neoplasms
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
Neoplasms
Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.
Neoplasms
The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin-regulated adrenocortical functions.
Neoplasms
The cellular mechanisms of corticotropin-releasing hormone (CRH)-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH.
Neoplasms
The differential regulation of steroidogenic acute regulatory protein-mediated steroidogenesis by type I and type II PKA in MA-10 cells.
Neoplasms
The in vitro effects of glycyrrhizin and the derivatives of glycyrrhetinic acid on the activity of cAMP-dependent protein kinase and phosphorylation of cellular polypeptide by the kinase from Ehrlich ascites tumor cells.
Neoplasms
The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related diseases.
Neoplasms
The relationship of the cyclic nucleotide system to inhibition of hepatic drug metabolism in Walker 256 carcinoma-bearing rats.
Neoplasms
The roles of cAMP and cAMP-dependent protein kinase in forskolin's actions on Y1 adrenocortical tumor cells.
Neoplasms
The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.
Neoplasms
The roles of cAMP and cAMP-dependent protein kinase in the regulation of adrenocortical functions: analysis using DNA-mediated gene transfer.
Neoplasms
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
Neoplasms
Type I and II cyclic adenosine 3':5'-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas.
Neoplasms
Ultrastructural localization of cyclic adenosine 3',5'-monophosphate-dependent protein kinase after adrenocorticotropin stimulation in adrenal cortical tumor cells.
Neoplasms
Update on the pathology of liver neoplasms.
Neoplasms
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Neoplasms
[Activation of protein kinase C and cAMP-dependent protein kinase in hormone-dependent mammary gland tumors during stimulation of their growth with progesterone and estrone]
Neoplasms
[Change in the protein kinase activity of glandular stomach mucosa in rats during malignant transformation]
Neoplasms
[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]
Neoplasms
[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]
Neoplasms
[The effect of estradiol on the activity of cAMP-dependent protein kinase in cells of estradiol-dependent tumors of the rat mammary gland. The role of a thermally stable protein inhibitor of cAMP-dependent protein kinase]
Neoplasms
[The inhibiting effect of 8-Cl-adenosine-3',5'-cyclophosphate on the growth of melanoma B-16 in mice]
Neuralgia
cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.
Neuralgia
cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain.
Neuralgia
Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.
Neuralgia
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Neuroblastoma
Activation of cyclic AMP-dependent protein kinase and stimulation of protein phosphorylation in response to adenosine in C-1300 murine neuroblastoma.
Neuroblastoma
Characterization of a minimal promoter element required for transcription of the mouse type II beta regulatory subunit (RII beta) of cAMP-dependent protein kinase.
Neuroblastoma
Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.
Neuroblastoma
Identification of functional cAMP-dependent protein kinase in a 'neurite minus' mouse neuroblastoma cell line.
Neuroblastoma
Induction of the regulatory subunit of type I adenosine cyclic 3':5'-monophosphate-dependent protein kinase in differentiated N-18 mouse neuroblastoma cells.
Neuroblastoma
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.
Neuroblastoma
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Neuroblastoma
Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma X glioma hybrid cells.
Neuroblastoma
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Neuroblastoma
Orphanin FQ/nociceptin and mu-opioid receptor mRNA levels in human SH-SY5Y neuroblastoma cells: effects of activating the cAMP-PKA signal transduction pathway.
Neuroblastoma
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Regulation of relaxin 3 gene expression via cAMP-PKA in a neuroblastoma cell line.
Neuroblastoma
The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene.
Neuroblastoma
The role of protein kinase C in cellular tolerance to ethanol.
Neuroblastoma
Type II protein kinase A up-regulation is sufficient to induce growth inhibition in SK-N-SH human neuroblastoma cells.
Neurodegenerative Diseases
Mitochondrial cAMP-PKA signaling: What do we really know?
Neurofibromatoses
Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase.
Neurofibromatosis 1
Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase.
non-specific serine/threonine protein kinase deficiency
High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.
Obesity
Hypothalamic PKA regulates leptin sensitivity and adiposity.
Obesity
Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.
Obesity
Obesity does not lead to imbalance between myocardial phospholamban phosphorylation and dephosphorylation.
Osteochondrodysplasias
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Osteoporosis
Angiotensin II/Angiotensin II Receptor Blockade Affects Osteoporosis via the AT1/AT2-Mediated cAMP-Dependent PKA Pathway.
Osteosarcoma
Activation of adenosine 3',5'-monophosphate-dependent protein kinase in normal and malignant bone cells by parathyroid hormone, prostaglandin E2, and prostacyclin.
Osteosarcoma
Activity ratio measurements reflect intracellular activation of adenosine 3',5'-monophosphate-dependent protein kinase in osteoblasts.
Osteosarcoma
Glucocorticoid and 1,25-dihydroxyvitamin D modulate the degree of adenosine 3',5'-monophosphate-dependent protein kinase isoenzyme I and II activation by parathyroid hormone in rat osteosarcoma cells.
Osteosarcoma
Glucocorticoid treatment facilitates cyclic adenosine 3',5'-monophosphate-dependent protein kinase response in parathyroid hormone-responsive osteogenic sarcoma cells.
Osteosarcoma
Protein kinase C modulates parathyroid hormone- but not prostaglandin E2-mediated stimulation of cyclic AMP production via the inhibitory guanine nucleotide binding protein in UMR-106 osteosarcoma cells.
Osteosarcoma
PTHrP, its receptor, and protein kinase A activation in osteosarcoma.
Osteosarcoma
Regulation of gene transcription and proliferation by parathyroid hormone is blocked in mutant osteoblastic cells resistant to cyclic AMP.
Osteosarcoma
Role of calcium/protein kinase C in the regulation of DNA synthesis by parathyroid hormone-related peptide in osteoblastic osteosarcoma cells.
Osteosarcoma
Selective hormonal activation of cyclic AMP-dependent protein kinase isoenzymes in normal and malignant osteoblasts.
Osteosarcoma
The activation of cAMP-dependent protein kinase is directly linked to homologous desensitization by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells.
Osteosarcoma
The direct involvement of cAMP-dependent protein kinase in the regulation of collagen synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblast-like osteosarcoma cells (UMR-106).
Osteosarcoma
The participation of the activation of cAMP-dependent protein kinase in cytosolic acidification by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells.
Ovarian Neoplasms
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.
Ovarian Neoplasms
Regulatory subunits of PKA define an axis of cellular proliferation/ differentiation in ovarian cancer cells.
Pancreatic Cyst
Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.
Paralysis
Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility.
Parasitic Diseases
A Schistosome cAMP-Dependent Protein Kinase Catalytic Subunit Is Essential for Parasite Viability.
Parathyroid Neoplasms
Phospholipid/Ca2+-dependent protein kinase activity in human parathyroid adenoma.
Parkinson Disease
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Parkinson Disease
The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.
Parkinsonian Disorders
Cyclic AMP-dependent protein kinase activity in the human brain: values in Parkinsonism.
Peripheral Vascular Diseases
Comparison of vasodilatory prostaglandins with respect to cAMP-mediated phosphorylation of a target substrate in intact human platelets.
Pheochromocytoma
Activation of rat pheochromocytoma tyrosine hydroxylase by a cyclic AMP-dependent protein kinase in a cell-free system.
Pheochromocytoma
Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.
Pheochromocytoma
Enhanced phosphorylation of tyrosine hydroxylase at more than one site is induced by 56 mM K+ in rat pheochromocytoma PC12 cells in culture.
Pheochromocytoma
Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.
Pheochromocytoma
Immunofluorescence localization of the regulatory subunit type II of cAMP-dependent protein kinase in PC12 and 3T3 cells in different proliferative states.
Pheochromocytoma
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Pheochromocytoma
Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.
Pheochromocytoma
Phosphorylation of rat tyrosine hydroxylase and its model peptides in vitro by cyclic AMP-dependent protein kinase.
Pheochromocytoma
Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.
Pheochromocytoma
Phosphorylation of tyrosine hydroxylase by cyclic GMP-dependent protein kinase.
Pheochromocytoma
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
Pheochromocytoma
Regulation of human tyrosine hydroxylase activity. Effects of cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion.
Pheochromocytoma
Regulation of the activity of tyrosine hydroxylase in the central nervous system.
Pheochromocytoma
The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.
Pheochromocytoma
The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene.
Pheochromocytoma
The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells.
Pheochromocytoma
The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor.
Pheochromocytoma
Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.
Pheochromocytoma
Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells.
Pituitary Neoplasms
Activators of protein kinase C and cyclic AMP-dependent protein kinase regulate intracellular calcium levels through distinct mechanisms in mouse anterior pituitary tumor cells.
Pituitary Neoplasms
Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.
Pituitary Neoplasms
Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis.
Pituitary Neoplasms
Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.
Pituitary Neoplasms
Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas.
Pituitary Neoplasms
Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. Preferential activation of protein kinase I by corticotropin releasing factor, isoproterenol, and forskolin.
Pituitary Neoplasms
Increased activity of type I regulatory subunit of cyclic adenosine 3',5'-monophosphate-dependent protein kinase in estrogen-induced pituitary tumors.
Pituitary Neoplasms
Liposome delivery of cyclic AMP-dependent protein kinase inhibitor into intact cells: specific blockade of cyclic AMP-mediated adrenocorticotropin release from mouse anterior pituitary tumor cells.
Pituitary Neoplasms
Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis.
Pituitary Neoplasms
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Pituitary Neoplasms
Post-transcriptional regulation of cAMP-dependent protein kinase activity by cAMP in GH3 pituitary tumor cells. Evidence for increased degradation of catalytic subunit in the presence of cAMP.
Polycystic Kidney Diseases
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycystic Kidney Diseases
cAMP-dependent protein kinase and proliferation differ in normal and polycystic kidney epithelia.
Polycystic Kidney Diseases
Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.
Polycystic Kidney, Autosomal Dominant
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Proliferative signaling by ERBB proteins and RAF/MEK/ERK effectors in polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
The Effect of cAMP-PKA Activation on TGF-?1-Induced Profibrotic Signaling.
Pre-Eclampsia
Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.
Prostatic Neoplasms
Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action.
Prostatic Neoplasms
Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness.
Prostatic Neoplasms
Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A.
Prostatic Neoplasms
Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type i? of protein kinase a in vivo.
Prostatic Neoplasms
Extracellular catalytic subunit activity of the cAMP-dependent protein kinase in prostate cancer.
Prostatic Neoplasms
Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway.
Prostatic Neoplasms
Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: Cross-talk with the androgen receptor.
Prostatic Neoplasms
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models.
protein acetyllysine n-acetyltransferase deficiency
Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice.
Pseudorabies
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.
Psoriasis
Oxidative modulation of cyclic AMP-dependent protein kinase in human fibroblasts: possible role in psoriasis.
Psoriasis
Post-translational abnormality of the type II cyclic AMP-dependent protein kinase in psoriasis: modulation by retinoic acid.
Pulmonary Disease, Chronic Obstructive
Progress in the mechanism and targeted drug therapy for COPD.
Reperfusion Injury
Effect of sevoflurane on the ATPase activity of hippocampal neurons in a rat model of cerebral ischemia-reperfusion injury via the cAMP-PKA signaling pathway.
Reperfusion Injury
Implication of Protein Kinase A for a Hepato-Protective Mechanism of Milrinone Pretreatment.
Reperfusion Injury
Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation via cAMP-PKA pathway.
Reperfusion Injury
Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity.
Retinoblastoma
Abnormal expression of the RI subunit of cyclic AMP-dependent protein kinase in Y-79 retinoblastoma cells.
Retinoblastoma
Distribution of the regulatory subunit of type II cAMP-dependent protein kinase in Y-79 retinoblastoma cells. Effect of butyrate.
Retinoblastoma
Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor.
Retinoblastoma
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.
Sandhoff Disease
Prostaglandin E2 reverses aberrant production of an inflammatory chemokine by microglia from Sandhoff disease model mice through the cAMP-PKA pathway.
Sarcoma
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Sarcoma
Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome.
Sarcoma
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma, Avian
Comparison of cAMP-dependent protein kinase in normal and Rous sarcoma virus transformed chick embryo fibroblasts.
Sarcoma, Avian
Concerted regulation of steroidogenic acute regulatory gene expression by luteinizing hormone and insulin (or insulin-like growth factor I) in primary cultures of porcine granulosa-luteal cells.
Schistosomiasis
Conservation of protein kinase a catalytic subunit sequences in the schistosome pathogens of humans.
Seizures
Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.
Seizures
Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex.
Seizures
Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA Pathway.
Seizures
Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures.
Sepsis
Differential activation of protein kinase A in various regions of myocardium during sepsis.
Sepsis
Liver protein kinase A activity is decreased during the late hypoglycemic phase of sepsis.
Sepsis
Protection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of beta2-adrenoceptor.
Sepsis
Protein kinase a activity is increased in rat heart during late hypodynamic phase of sepsis.
Sepsis
[Changes in the calcium channels in rat cardiac cells during sepsis]
Sepsis
[Impaired calcium uptake by cardiac sarcoplasmic reticulum and its underlying mechanism during rat septic shock]
Sepsis
[Kinetic studies of protein kinase A in rat liver during late sepsis]
Spinal Cord Injuries
Spinal activation of the cAMP-PKA pathway induces respiratory motor recovery following high cervical spinal cord injury.
Spinal Cord Ischemia
Reduced protein kinase C activity in ischemic spinal cord.
Spinocerebellar Ataxias
Regulation of ataxin-1 phosphorylation and its impact on biology.
Starvation
A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development.
Starvation
AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.
Starvation
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.
Starvation
Crosstalk between cAMP-PKA and MAP kinase pathways is a key regulatory design necessary to regulate FLO11 expression.
Starvation
Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans.
Starvation
Modulation of expression of the stress-inducible p118 of Saccharomyces cerevisiae by cAMP. II. A study of p118 expression in mutants of the cAMP cascade.
Starvation
Phosphorylation of the protein kinase A catalytic subunit is induced by cyclic AMP deficiency and physiological stresses in the fission yeast, Schizosaccharomyces pombe.
Starvation
RAM pathway contributes to Rpb4 dependent pseudohyphal differentiation in Saccharomyces cerevisiae.
Starvation
Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase.
Starvation
Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway.
Starvation
The lag phase rather than the exponential-growth phase on glucose is associated with a higher cAMP level in wild-type and cAPK-attenuated strains of the yeast Saccharomyces cerevisiae.
Starvation
The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.
Starvation
The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.
Stomach Neoplasms
[Regulation of traditional Chinese medicine formulae bailong on cAMP-PKA and DAG-PKC signal pathways of human gastric cancer cells]
Teratocarcinoma
Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity.
Teratocarcinoma
Retinoic acid-induced rapid loss of nuclear cyclic AMP-dependent protein kinase in teratocarcinoma cells.
Thrombosis
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Thyroid Cancer, Papillary
Growth regulation of the human papillary thyroid cancer cell line by protein tyrosine kinase and cAMP-dependent protein kinase.
Thyroid Cancer, Papillary
Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain.
Thyroid Neoplasms
Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.
Tuberculosis
Elevated cyclic AMP Inhibits Mycobacterium tuberculosis-stimulated T cell IFN-? Secretion through type I Protein Kinase A.
Vascular Diseases
Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
Vascular System Injuries
Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury.
Vascular System Injuries
Analysis of Genes Related to Angiotensin II-Induced Arterial Injury Using a Time Series Microarray.
Vascular System Injuries
Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals.
Virus Diseases
Polarized Trout Epithelial Cells Regulate Transepithelial Electrical Resistance, Gene Expression, and the Phosphoproteome in Response to Viral Infection.
Vitamin D Deficiency
Cyclic AMP dependent protein kinase and its endogenous inhibitor protein: tissue distribution and effect of vitamin D status in the chick.
Vitamin D Deficiency
Effect of vitamin D status on cyclic AMP-dependent protein kinase activity and its heat-stable inhibitor in chick kidney.
Vitamin D Deficiency
Effect of vitamin D status on the activity of carbonic anhydrase in chicken epiphysis and kidney.
Whooping Cough
17?-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor.
Whooping Cough
Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.
Whooping Cough
Activation of metabotropic glutamate receptors by L-AP4 stimulates survival of rat cerebellar granule cells in culture.
Whooping Cough
Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells.
Whooping Cough
ATP produces potassium currents via P3 purinoceptor in the follicle cell layer of Xenopus oocytes.
Whooping Cough
beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf.
Whooping Cough
Differential calcium regulation of proinflammatory activities in human neutrophils exposed to the neuropeptide pituitary adenylate cyclase-activating protein.
Whooping Cough
Effects of phosphorylation of inhibitory GTP-binding protein by cyclic AMP-dependent protein kinase on its ADP-ribosylation by pertussis toxin, islet-activating protein.
Whooping Cough
Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.
Whooping Cough
Ghrelin signalling in guinea-pig femoral artery smooth muscle cells.
Whooping Cough
Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes.
Whooping Cough
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.
Whooping Cough
Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer.
Whooping Cough
Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils.
Whooping Cough
N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.
Whooping Cough
Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways.
Whooping Cough
Neural effects of parathyroid hormone: modulation of the calcium channel current and metabolism of monoamines in identified Helisoma snail neurons.
Whooping Cough
Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.
Whooping Cough
Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus.
Whooping Cough
Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.
Whooping Cough
Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma.
Whooping Cough
SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway.
Whooping Cough
The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors.
Wilms Tumor
Distribution and properties of type I and type II binding proteins in the cyclic adenosine 3':5'-monophosphate-dependent protein kinase system in Wilms' tumor.
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2.7.11.11 cAMP-dependent protein kinase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).