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Information on EC 2.7.11.10 - IkappaB kinase and Organism(s) Homo sapiens and UniProt Accession Q14164

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.10 IkappaB kinase
IUBMB Comments
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
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This record set is specific for:
Homo sapiens
UNIPROT: Q14164
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
ikappabalpha, ikkbeta, ikappab kinase, ikkalpha, ikk complex, lrrk2 kinase, tank-binding kinase 1, ikk-beta, ikkepsilon, ikk-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
I-kappa-B kinase epsilon
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IkappaB kinase epsilon
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IKKepsilon
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inhibitor of nuclear factor kappa-B kinase epsilon subunit
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CHUK
-
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I kappa B kinase alpha
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I-kappa B kinase epsilon
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Ikappa B kinase alpha
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IkappaB alpha kinase
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IkappaB kinase alpha
IkappaB kinase beta
IkappaB kinase complex
-
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IkappaB kinase-1
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IkappaB kinase-2
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IkappaB kinase-beta
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IkappaBalpha
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IkappaBalpha kinase
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IkappaBbeta kinase
-
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IKK complex
-
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IKK-beta
IKKalpha
IKKbeta
IKKepsilon
-
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inhibitor kappa-B kinase-beta
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inhibitor of kappaB kinase
-
-
inhibitor of nuclear factor kappa B kinase beta subunit inhibitor of nuclear factor kappa-B kinase alpha subunit
inhibitory kappa B kinase alpha
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inhibitory kappa B kinase beta
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]
show the reaction diagram
activation and reaction mechanism
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:[IkappaB protein] phosphotransferase
The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.
CAS REGISTRY NUMBER
COMMENTARY hide
159606-08-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + interferon regulatory factor 3
ADP + phosphorylated interferon regulatory factor 3
show the reaction diagram
-
-
-
?
ATP + STAT1 transcription factor
ADP + phosphorylated STAT1 transcription factor
show the reaction diagram
-
-
-
?
ATP + [IkappaB protein]
ADP + [IkappaB phosphoprotein]
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + Bcl
ADP + phosphorylated Bcl
show the reaction diagram
ATP + Bcl
ADP + phosphorylated Bcl10
show the reaction diagram
-
Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl
-
-
?
ATP + Bcl10
ADP + phosphorylated Bcl10
show the reaction diagram
-
negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview
-
-
?
ATP + GST-IkappaBalpha
ADP + GST-IkappaBalpha phosphoprotein
show the reaction diagram
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activity assay
-
-
?
ATP + IkappaB alpha
ADP + phosphorylated IkappaB alpha
show the reaction diagram
-
-
-
?
ATP + IkappaB protein
ADP + IkappaB phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + IkappaBalpha
ADP + phosphorylated IkappaBalpha
show the reaction diagram
ATP + KKKKERLLDDRHDSGLDSMKDEE
ADP + phosphorylated-KKKKERLLDDRHDSGLDSMKDEE
show the reaction diagram
-
IKK substrate peptide derived from IkappaBalpha sequence
-
-
?
ATP + NF-kappaB
ADP + phosphorylated NF-kappaB
show the reaction diagram
-
-
-
-
?
ATP + NF-kappaB p65 subunit
ADP + phosphorylated NF-kappaB p65 subunit
show the reaction diagram
-
IKKalpha and IKKbeta phosphorylate NF-kappaB p65 subunit at Ser536
-
-
?
ATP + p65/RelA
ADP + phosphorylated p65/RelA
show the reaction diagram
-
-
-
?
ATP + [acetylated histone H3 protein]
ADP + [acetylated histone H3 phosphoprotein]
show the reaction diagram
ATP + [biotinylated IkappaBa peptide]
ADP + [biotinylated IkappaBa phosphopeptide]
show the reaction diagram
i.e. biotin-Gly-Leu-Lys-Lys-Glu-Arg-Leu-Leu-Asp-Asp-Arg-His-Asp-Ser32-Gly-Leu-Asp-Ser36-Met-Lys-Asp-Glu-Glu
-
-
?
ATP + [DELTANp73alpha protein]
ADP + [DELTANp73alpha phosphoprotein]
show the reaction diagram
-
phosphorylation at Ser422 by IKKbeta, IKKbeta is inactive with S422A mutant substrate. DELTANp73alpha i a dominant negative inhibitor of p53 and p73
-
-
?
ATP + [GST-IkappaB protein]
ADP + [GST-IkappaB phosphoprotein]
show the reaction diagram
-
-
-
-
?
ATP + [GST-IkappaBalpha protein]
ADP + [GST-IkappaBalpha phosphoprotein]
show the reaction diagram
-
-
-
-
?
ATP + [GST-IkappaBalpha1-54 protein]
ADP + [GST-IkappaBalpha1-54 phosphoprotein]
show the reaction diagram
-
-
-
-
?
ATP + [histone H3 protein]
ADP + [histone H3 phosphoprotein]
show the reaction diagram
ATP + [IkappaB protein]
ADP + [IkappaB phosphoprotein]
show the reaction diagram
ATP + [IkappaBalpha protein]
ADP + [IkappaBalpha phosphoprotein]
show the reaction diagram
ATP + [IkappaBbeta protein]
ADP + [IkappaBbeta phosphoprotein]
show the reaction diagram
ATP + [NFkappaB subunit p56]
ADP + [NFkappaB subunit p56]phosphate
show the reaction diagram
ATP + [p73 protein]
ADP + [p73 phosphoprotein]
show the reaction diagram
-
IKKalpha in the nucleus
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [IkappaB protein]
ADP + [IkappaB phosphoprotein]
show the reaction diagram
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + Bcl
ADP + phosphorylated Bcl
show the reaction diagram
-
phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling
-
-
?
ATP + Bcl10
ADP + phosphorylated Bcl10
show the reaction diagram
-
negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview
-
-
?
ATP + IkappaBalpha
ADP + phosphorylated IkappaBalpha
show the reaction diagram
ATP + NF-kappaB
ADP + phosphorylated NF-kappaB
show the reaction diagram
-
-
-
-
?
ATP + [acetylated histone H3 protein]
ADP + [acetylated histone H3 phosphoprotein]
show the reaction diagram
-
IKKalpha is required for histone function regulation in the nucleus
-
-
?
ATP + [GST-IkappaB protein]
ADP + [GST-IkappaB phosphoprotein]
show the reaction diagram
-
-
-
-
?
ATP + [GST-IkappaBalpha protein]
ADP + [GST-IkappaBalpha phosphoprotein]
show the reaction diagram
-
-
-
-
?
ATP + [histone H3 protein]
ADP + [histone H3 phosphoprotein]
show the reaction diagram
ATP + [IkappaB protein]
ADP + [IkappaB phosphoprotein]
show the reaction diagram
ATP + [IkappaBalpha protein]
ADP + [IkappaBalpha phosphoprotein]
show the reaction diagram
ATP + [IkappaBbeta protein]
ADP + [IkappaBbeta phosphoprotein]
show the reaction diagram
-
-
-
-
?
ATP + [NFkappaB subunit p56]
ADP + [NFkappaB subunit p56]phosphate
show the reaction diagram
-
-
-
-
?
ATP + [p73 protein]
ADP + [p73 phosphoprotein]
show the reaction diagram
-
IKKalpha in the nucleus
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE