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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Mus musculus and UniProt Accession Q9Z265

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IUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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This record set is specific for:
Mus musculus
UNIPROT: Q9Z265
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
serine/threonine-protein kinase Chk2
-
3-phosphoinositide dependent protein kinase-1
-
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
AMH type II receptor
-
-
-
-
Anti-sigma B factor rsbT
-
-
-
-
AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
BUB1 protein kinase
-
c-Jun N-terminal kinase
-
-
calcium and calmodulin-dependent serine/threonine protein kinase type II
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
CaMKII
-
-
cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
-
casein kinase 1
-
casein kinase 1delta
casein kinase 2
casein kinase I
-
-
-
-
casein kinase I, epsilon isoform
-
casein kinase II
casein kinase-2
-
-
-
-
CD43-associated serine/threonine kinase
-
CDC25 suppressing protein kinase
-
-
-
-
Cell division cycle 2-like
-
-
-
-
cell division cycle 7-related protein kinase
-
CK-2
-
-
-
-
CK1delta
CK1epsilon
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CKII
-
-
-
-
CLP-36 interacting kinase
-
-
-
-
CSNK1D
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DM-kinase
-
DNA-PKcs
-
-
-
-
DNPK1
-
-
-
-
dSTPK61
-
-
-
-
G11 protein
-
-
-
-
glycogen synthase kinase-3alphabeta
-
-
hARK1
-
-
-
-
histone kinase
-
-
-
-
homeodomain-interacting protein kinase 2
-
hormonally upregulated neu tumor-associated kinase
-
hPDK1
-
-
-
-
Hpr kinase
-
-
-
-
hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
-
Kinase interacting with stathmin
-
-
-
-
kinase, casein (phosphorylating)
-
-
-
-
kinase, protamine (phosphorylating)
-
-
-
-
kinase, protein (phosphorylating)
-
-
-
-
kinase, protein, A (phosphorylating)
-
-
-
-
kinase, protein, C (phosphorylating)
-
-
-
-
LIM domain kinase 1
-
LKB1
-
-
Lymphocyte-oriented kinase
-
-
-
-
M phase-specific cdc2 kinase
-
-
-
-
microtubule-associated serine/threonine kinase family
-
mitogen-activated S6 kinase
-
-
-
-
mitotic checkpoint serine/threonine-protein kinase BUB1
-
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
-
mPDK1
-
-
-
-
MPK38
MPSK
-
-
-
-
murine protein serine-threonine kinase 38
-
-
Murine serine-threonine kinase 38
-
myotonic dystrophy protein kinase
-
myotonin-protein kinase
-
Myristoylated and palmitoylated serine-threonine kinase
-
-
-
-
NY-REN-55 antigen
-
-
-
-
P-CIP2
-
-
-
-
P21-activated kinase-1
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
-
p53-related protein kinase
-
p70 ribosomal S6 kinase 1
-
-
p82 kinase
-
-
-
-
pEg2
-
-
-
-
peripheral plasma membrane protein CASK
-
phosphoinositide-dependent kinase-1
-
-
phosphoinositide-dependent protein kinase-2
-
phosphorylase b kinase kinase
-
-
-
-
Phototropin
-
-
-
-
Pim-2h
-
-
-
-
Pim1 serine/threonine kinase
-
PKA
-
-
-
-
PkB kinase
-
-
-
-
pp39-mos
-
-
-
-
Pre-mRNA protein kinase
-
-
-
-
protamine kinase
-
-
-
-
protein glutamyl kinase
-
-
-
-
protein kinase (phosphorylating)
-
-
-
-
protein kinase B gamma
-
Protein kinase B kinase
-
-
-
-
protein kinase C, mu type
-
protein kinase CK2
-
-
-
-
protein kinase Cmu
-
protein kinase D
-
Protein kinase Krct
-
-
-
-
Protein kinase MST
-
-
-
-
protein kinase p58
-
-
-
-
Protein kinase PKL12
-
-
-
-
protein kinase Sgk
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
-
protein-serine/threonine kinase
-
-
-
-
PRP4 kinase
-
-
-
-
PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
pyruvate dehydrogenase kinase 1
-
RAC-alpha serine/threonine kinase
-
RAC-beta serine/threonine protein kinase
-
RAC-gamma serine/threonine protein kinase
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
-
Rho-associated kinase 1
-
-
Rho-associated kinase II
-
-
ribosomal protein S6 kinase alpha 1
-
ribosomal protein S6 kinase alpha 2
-
ribosomal protein S6 kinase beta 2
-
ribosomal protein S6 kinase II
-
-
-
-
ribosomal S6 kinase 2
-
-
ribosomal S6 protein kinase
-
-
-
-
ROCK1
-
-
ROCKII
-
-
RP1 protein
-
-
-
-
RSK2
-
-
S-receptor kinase
-
-
-
-
S6K1
-
-
S6K2
-
-
Ser/Thr kinase
-
-
serine kinase
-
-
-
-
serine protein kinase
-
-
-
-
serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine-threonine kinase
-
serine-threonine kinase B
-
serine/threonine kinase
Serine/threonine kinase 15
-
-
-
-
Serine/threonine kinase Ayk1
-
-
-
-
serine/threonine protein kinase
serine/threonine protein kinase 16
-
serine/threonine protein kinase 31
-
serine/threonine-protein kinase Chk1
-
serine/threonine-protein kinase DCAMKL1
-
serine/threonine-protein kinase Kist
-
Serine/threonine-protein kinase NRK2
-
-
-
-
Serine/threonine-protein kinase NYD-SPK
-
-
-
-
serine/threonine-protein kinase PAK 1
-
serine/threonine-protein kinase PAK 3
-
serine/threonine-protein kinase Sgk
-
serine/threonine-protein kinase ULK1
-
SRK
-
-
-
-
Ste20-like kinase
-
-
-
-
STE20-like kinase MST1
-
-
-
-
STE20-like kinase MST2
-
-
-
-
STE20-like kinase MST3
-
-
-
-
STE20/SPS1-related proline-alanine rich protein kinase
-
STK11
-
-
Switch protein/serine kinase
-
-
-
-
T-antigen kinase
-
-
-
-
testis specific serine/threonine kinase 4
A3QQQ9
-
testis-specific kinase 4
UniProt
testis-specific serine/threonine kinase
-
-
testis-specific serine/threonine kinase 4
-
testis-specific serine/threonine protein kinase 5 variant alpha
A3QQQ9
-
testis-specific serine/threonine protein kinase 5 variant beta
A9P6P7
-
testis-specific serine/threonine protein kinase 5 variant delta
A9P6P9
-
testis-specific serine/threonine protein kinase 5 variant gamma
A3QQR1
-
threonine Pim kinase
-
threonine-specific protein kinase
-
-
-
-
TPL2
-
-
TSK-4
UniProt
TSSK-4
UniProt
Tssk3
-
-
Tssk4
TSSK5
A3QQQ9
-
tumor progression locus 2 serine/threonine kinase
-
-
Twitchin kinase
-
-
-
-
type-2 casein kinase
-
-
-
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
show the reaction diagram
catalytic mechanism and regulation of PKN
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
CAS REGISTRY NUMBER
COMMENTARY hide
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + Cdc25C
ADP + phosphorylated Cdc25C
show the reaction diagram
phosphorylated Cdc25C on Ser216
-
-
?
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + AKAP450
ADP + phospho-AKAP450
show the reaction diagram
ATP + AMP-activated protein kinase
ADP + phosphorylated AMP-activated protein kinase
show the reaction diagram
-
-
-
-
?
ATP + apoptosis signal-regulating kinase 1
ADP + phosphorylated-apoptosis signal-regulating kinase 1
show the reaction diagram
MPK28 stimulates APK1 activity by Thr838 phosphorylation
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
show the reaction diagram
-
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
-
substrate of TSSK3
-
-
?
ATP + Cre-responsive element modulator
ADP + phospho-Crem
show the reaction diagram
ATP + Crem protein
ADP + phosphorylated Crem protein
show the reaction diagram
the enzyme phosphorylates Crem protein at Ser117
-
-
?
ATP + GST-CREB2 protein
ADP + phosphorylated GST-CREB2 protein
show the reaction diagram
-
-
-
-
?
ATP + GST-NFAT3D4-261-365
ADP + phosphorylated GST-NFAT3D4-261-365
show the reaction diagram
-
-
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
ATP + histone H2A
ADP + phosphorylated histone H2A
show the reaction diagram
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2AX
ADP + phosphorylated histone H2AX
show the reaction diagram
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H2B
ADP + phosphorylated histone H2B
show the reaction diagram
recombinant human substrate, substrate of SSTK
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
ATP + histone H4
ADP + phosphorylated histone H4
show the reaction diagram
recombinant substrate from Xenopus laevis, substrate of SSTK
-
-
?
ATP + ICAP-1alpha protein
ADP + phosphorylated ICAP-1alpha protein
show the reaction diagram
-
phosphorylated at threonine 38
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
ATP + myelin basic protein kinase
ADP + phosphorylated myelin basic protein kinase
show the reaction diagram
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
show the reaction diagram
ATP + p53 protein
ADP + phosphorylated p53 protein
show the reaction diagram
-
at Ser15
-
-
?
ATP + PACSIN 1 protein
ADP + phospho-PACSIN 1 protein
show the reaction diagram
i.e. casein kinase 2 substrate in neurons 1 protein, casein kinase 2 phosphorylates PACSIN 1 at Ser358, no activity with PACSIN1 mutant S358A. Ser358 is located within the unstructured linker sequence connecting the N-terminal F-BAR domain with the C-terminal SH3 domain
-
-
?
ATP + PACSIN protein
ADP + phosphorylated PACSIN protein
show the reaction diagram
-
phosphorylation at Ser358
-
-
?
ATP + PER2 protein
ADP + phosphorylated PER2 protein
show the reaction diagram
ATP + protein
?
show the reaction diagram
ATP + protein
ADP + a phosphoprotein
show the reaction diagram
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro
-
-
?
ATP + protein kinase C
ADP + phospho-protein kinase C
show the reaction diagram
-
-
-
?
ATP + protein kinase C
ADP + phosphorylated protein kinase C
show the reaction diagram
-
-
-
-
?
ATP + protein kinase Czeta
ADP + phosphorylated protein kinase Czeta
show the reaction diagram
phosphorylation and activation of protein kinase Czeta
-
-
?
ATP + protein p21
ADP + phosphoprotein p21
show the reaction diagram
-
threonine 57, threonine 145, serine 98, serine 130, and serine 146 are phosphorylated by JNK, JNK mediates stabilization of protein p21 via the phosphorylation of threonine 57
-
-
?
ATP + pyruvate dehydrogenase complex
ADP + phosphorylated pyruvate dehydrogenase complex
show the reaction diagram
-
-
-
?
ATP + Rab8a protein
ADP + phosphorylated Rab8a protein
show the reaction diagram
-
-
-
-
?
ATP + RRSSSY
ADP + RRSS-phosphoS-Y
show the reaction diagram
-
peptide substrate of TSSK3 consisting of the consensus sequence
-
-
?
ATP + SF2/ASF
ADP + phosphorylated SF2/ASF
show the reaction diagram
SF2/ASF is a human SR splicing factor, phosphorylation in the RS domain
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
ATP + stathmin
ADP + phosphorylated stathmin
show the reaction diagram
phosphorylates on Ser
-
-
?
ATP + testis-specific serine-threonine kinase 3
ADP + phosphorylated testis-specific serine-threonine kinase 3
show the reaction diagram
ATP + Trx-His-S-CREB protein
ADP + phosphorylated Trx-His-S-CREB protein
show the reaction diagram
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
i.e. thioredoxin fusion cAMP responsive element binding protein, phosphorylation at Ser133
-
-
?
ATP + vimentin
ADP + phosphorylated vimentin
show the reaction diagram
kinase assays demonstrate that Stk33 is able to specifically phosphorylate the non-alpha-helical amino-terminal domain of vimentin in vitro
-
-
?
ATP + [pyruvate dehydrogenase (acetyl-transferring)]
ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
show the reaction diagram
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
casein + ATP
phosphorylated casein + ADP
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + AKAP450
ADP + phospho-AKAP450
show the reaction diagram
-
-
-
?
ATP + AMP-activated protein kinase
ADP + phosphorylated AMP-activated protein kinase
show the reaction diagram
-
-
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
show the reaction diagram
-
-
-
-
?
ATP + Cre-responsive element modulator
ADP + phospho-Crem
show the reaction diagram
Tssk-4 phosphorylates Cre-responsive element modulator, Crem, at Ser117
-
-
?
ATP + Crem protein
ADP + phosphorylated Crem protein
show the reaction diagram
the enzyme phosphorylates Crem protein at Ser117
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
show the reaction diagram
-
RSK2 is a key regulator of histone H3 phosphorylation
-
-
?
ATP + ICAP-1alpha protein
ADP + phosphorylated ICAP-1alpha protein
show the reaction diagram
-
phosphorylated at threonine 38
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
show the reaction diagram
-
the enzyme (ROCK1) is a key regulator of actin cytoskeleton and cell polarity. ROCK1 directly induces the phosphorylation of myosin light chains (MLC) or inactivates the phosphorylated myosin phosphatase-binding subunit (MYPT), thereby directly or indirectly increases MLC phosphorylation
-
-
?
ATP + PACSIN 1 protein
ADP + phospho-PACSIN 1 protein
show the reaction diagram
i.e. casein kinase 2 substrate in neurons 1 protein, casein kinase 2 phosphorylates PACSIN 1 at Ser358, no activity with PACSIN1 mutant S358A. Ser358 is located within the unstructured linker sequence connecting the N-terminal F-BAR domain with the C-terminal SH3 domain
-
-
?
ATP + PACSIN protein
ADP + phosphorylated PACSIN protein
show the reaction diagram
-
phosphorylation at Ser358
-
-
?
ATP + PER2 protein
ADP + phosphorylated PER2 protein
show the reaction diagram
-
S659A mutation sensitizes PER2 to CK1delta mediated degradation
-
-
?
ATP + protein
?
show the reaction diagram
ATP + protein
ADP + phosphoprotein
show the reaction diagram
potentially important role in the control of the cellular architecture and/or signaling in the central nervous system
-
-
?
ATP + protein
ADP + protein tyrosine phosphate
show the reaction diagram
GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro
-
-
?
ATP + protein kinase C
ADP + phospho-protein kinase C
show the reaction diagram
-
-
-
?
ATP + protein kinase C
ADP + phosphorylated protein kinase C
show the reaction diagram
-
-
-
-
?
ATP + protein kinase Czeta
ADP + phosphorylated protein kinase Czeta
show the reaction diagram
phosphorylation and activation of protein kinase Czeta
-
-
?
ATP + Rab8a protein
ADP + phosphorylated Rab8a protein
show the reaction diagram
-
-
-
-
?
ATP + SR protein
ADP + ?
show the reaction diagram
ATP + testis-specific serine-threonine kinase 3
ADP + phosphorylated testis-specific serine-threonine kinase 3
show the reaction diagram
-
substrate of phosphoinositide-dependent kinase-1 leading to activation
-
-
?
ATP + [pyruvate dehydrogenase (acetyl-transferring)]
ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
show the reaction diagram
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
-
activity in organisms with mutated APP and tau, not in wild-type, overview
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-phosphoinositide
enzyme is dependent on
Calmodulin
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
dependent on
Mn2+
-
preferred cation, optimal at 10 mM
additional information
-
divalent cations are required for activity
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-oleoyl-2-acetylglycerol
inhibits phorbol ester binding
kaempferol
-
an inhibitor of RSK2 invitro and in vivo, and suppresses proliferation and EGF-induced transformation in JB6 Cl41 cells, overview
luteolin
-
i.e. 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-chromenone, directly inhibits TPL2 activity, luteolin binds to TPL2 in an ATP-competitive manner, binding mode of luteolin, molecular modeling and docking study, overview. Luteolin easily docks to the ATP binding site of TPL2, which is located between the N-lobe and C-lobe of the kinase domain. In a cellular system, phosphorylation of TPL2 is increased by luteolin treatment, and luteolin suppresses TNF-alpha-induced TPL2 activity in JB6 P+ cells
MK2206
W80A mutation confers resistance to the Akt inhibitor MK2206
-
PF670462
a CK1delta/epsilon kinase inhibitor
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
activated His-tagged Cdc42Hs
stimulates mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro
-
arachidonic acid
-
activates in vitro, binds at the autoinhibitory site at the C-terminus
brain-derived neurotrophic factor
BDNF
-
His-tagged Rac
stimulates mPAK-3 autophosphorylation and phosphorylation of myelin basic protein by mPAK-3 in vitro
-
inositol 6-phosphate
specifically induces PACSIN 1 phosphorylation
lysophosphatidic acid
-
activates isozyme PKNalpha
RhoA
-
small GTPase, binds to the ACC domain and activates isozymes PKNalpha and PRK2/PKNgamma/PAK-2
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.145
myelin basic protein
-
pH 7.4, 30°C, recombinant TSSK3
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
Cardiac Pak1 activity is markedly increased by transverse aortic constriction in both C57BL/6 and FVBN mice
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2
-
assay at
7.4
-
TSSK3
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 8.2
-
TSSK3 shows a broad range pH-optimum
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9.1
amino acid sequence calculation
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
rat BUB1 mRNA accumulation correlates with the proliferation status of cells in culture
Manually annotated by BRENDA team
MAST3 shows selective expression in striatum and cortex as determined by in situ hybridization
Manually annotated by BRENDA team
MAST3 shows selective expression in striatum and cortex as determined by in situ hybridization
Manually annotated by BRENDA team
-
tumour-promotion-sensitive P+
Manually annotated by BRENDA team
-
isozyme PRK2/PKNgamma/PAK-2
Manually annotated by BRENDA team
expression detected by RT-PCR
Manually annotated by BRENDA team
primary hippocampal neurons
Manually annotated by BRENDA team
MAST4 shows selective expression in oligodendrozytes
Manually annotated by BRENDA team
sertoli cell culture SerW3 is used
Manually annotated by BRENDA team
expression detected by RT-PCR
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
low activity
Manually annotated by BRENDA team
kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
-
the serine/threonine kinase LKB1 is the main upstream kinase of the AMP-activated protein kinase cascade that senses cellular energy state and adjusts cellular metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CHK2_MOUSE
546
0
61088
Swiss-Prot
other Location (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
x * 35000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 35000, SDS-PAGE
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K39R
-
site-directed mutagenesis, inactive mutant
K40R
kinase-dead MPK38 mutant shows no complex formation with ASK1 since MPK38-ASK1 complex formation is dependent on the activities of both kinases
K54M
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
site-directed mutagenesis of splicing variant TSSKalpha
S166A
-
site-directed mutagenesis, mutation of a T-loop residue, highly reduced kinase activity compared to the wild-type TSSK3, no autophosphorylation
S166D
-
site-directed mutagenesis, mutation of a T-loop residue, reduced kinase activity compared to the wild-type TSSK3, no autophosphorylation
S166G
-
site-directed mutagenesis, mutation of a T-loop residue, highly reduced kinase activity compared to the wild-type TSSK3, no autophosphorylation
S347A
-
non-phosphorylatable mutant enzyme of CK1delta exhibits higher specific activity on PER2 protein
S370A
-
site-directed mutagenesis, S6K2 mutant is inactive
S370D
-
site-directed mutagenesis, S6K2 mutant is inactive
T168A
-
site-directed mutagenesis, mutation of a T-loop residue, inactive TSSK3 mutant, no autophosphorylation
T168D
-
site-directed mutagenesis, mutation of a T-loop residue, unaltered kinase activity and reduced autophosphorylation compared to the wild-type TSSK3
T197A
A3QQQ9
site-directed mutagenesis of the autophosphorylation site Thr residue of isozyme Tssk4
T228A
-
site-directed mutagenesis, S6K2 mutant shows reduced activation compared to the wild-type enzyme
T228A/T338E
-
site-directed mutagenesis, S6K2 mutant is inactive
T228E
-
site-directed mutagenesis, S6K2 mutant shows highly reduced activation compared to the wild-type enzyme
T256A
the conditional IPTG inducible expression of wild type Sgk, but not of the kinase dead mutant T256A Sgk, protects Con8 mammary epithelial tumor cells from serum starvation-induced apoptosis
T256A/S422A
unlike the wild-type enzyme the phosphorylation site mutant has no effect on cell survival
T338E
-
site-directed mutagenesis, S6K2 mutant is fully active and rapamycin-resistant, while the S6K1 mutant is inactive
W80A
the mutation confers resistance to the Akt inhibitor MK2206
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
glutathione-immobilized bead chromatography, and gel filtration
protein A-coupled Sepharose bead chromatography
-
recombinant GST-tagged wild-type Tssk4 and Myc-Tssk4T197A mutant from HEK-293T cells by glutathione affinity and immunoaffinity chromatography, respectively. Native Tssk4 from testis gland by immunoaffinity precipitation
A3QQQ9
recombinant wild-type and mutant GST-fusion TSSK3s by glutathione affinity chromatography, recombinant Myc-tagged catalytic subunit of phosphoinositide-dependent kinase-1 from human 293T cells
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alpha'-subunit
bacterially expressed catalytic domain of PKD
ectopic overexpression of RSK2 in MEF cells induces anchorage-independent cell transformation
-
expressed in Escherichia coli
expressed in Escherichia coli BL21 cells
expression in COS7 cells
expression of wild-type and mutant GST-fusion TSSK3s in Escherichia coli strain BL21, expression of Myc-tagged catalytic subunit of phosphoinositide-dependent kinase-1 in human 293T cells
-
expression of wild-type and mutant GST-tagged MPK38 in human in MCF-7, HEK-293, H-1299, and HCT-116 cells, coexpression with FLAG-tagged p53
-
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant beta, expression of wild-type Myc-tagged TSSKbeta in HEK-293T cells
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant gamma, expression of wild-type Myc-tagged TSSKdelta in HEK-293T cells
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant gamma, expression of wild-type Myc-tagged TSSKgamma in HEK-293T cells
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
gene tssk4, localization on chromosome 14qC3, DNA and amino acid sequence determination and analysis of splicing variant TSSKalpha, expression of wild-type and mutant Myc-tagged TSSKalpha in HEK-293T cells
A3QQQ9, A3QQR1, A9P6P7, A9P6P9
gene Tssk4, recombinant expression of GST-tagged Tssk4 in Escherichia coli strain BL21
in COS cells transfected with Kiz-1 complementary DNA Kiz-1 is found mainly in the cytoplasm
isolation and characterization of cDNA
isolation of cDNA
isozyme Tssk4, DNA and amino acid sequence determination and analysis, recombinant expression of GST-tagged wild-type isozyme Tssk4 and of Myc-Tssk4T197A mutant in HEK-293T cells
A3QQQ9
isozymes Tssk1, Tssk2, and Tssk3, DNA and amino acid sequence determination and analysis, recombinant expression of the isozymes in HEK-293T cells
A3QQQ9
located at the distal end of mouse chromosome 5
PKNalpha gene mapps to 19p12-p13.1 of chromosome 8 situated at the prostanoid receptor gene locus
-
recombinant CK1 undergoes autoinactivation via autophosphorylation in Escherichia coli cells and thus is undesirably prepared as a phosphorylated and inactivated kinase. To circumvent this problem, a protein expression system is established using Escherichia coli strain BL21(DE3)plambdaPP in which lambda protein phosphatase (lambdaPPase) is constitutively expressed. Using this system, recombinant CK1 isoforms (alpha, delta and epsilon) are readily prepared as unphosphorylated forms. CK1s prepared using BL21(DE3)plambdaPP show markedly higher activity than those prepared by the conventional BL21(DE3). The kinase activity of CK1delta from BL21(DE3)plambdaPP is higher than that prepared by a conventional method consisting of troublesome steps such as in vitro lambdaPPase treatment. The simple method using BL21(DE3)plambdaPP is valuable for preparing highly active CK1s
SSTK gene, DNA and amino acid sequence determination and analysis, transient expression of Myc-tagged SSTK in 293T cells
Tssk1 and Tssk2 genes are tandemly located on chromosome 16 separated by an intergenic region of only 3.06 kb
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
hypoxia upregulates isoform PDK1. Isoform Pdk1 expression is upregulated by hypoxia inducible factor 1alpha during hypoxic culture of LSK cells in vitro
Pim1 mRNA is upregulated by interleukin-3, interleukin-6 and TPO. In contrast, Pim2 and Pim3 mRNA expression is not changed with these cytokines
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
high-tidal-volume ventilation induced microvascular permeability, lung fibrosis, and chemokine production are dependent, in part, on activation of the Akt and ERK1/2 pathways
molecular biology
results demonstrate that MPK38 physically interacts with ASK1 in vivo and acts as a positive upstream regulator of ASK1
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bernard, O.; Ganiatsas, S.; Kannourakis, G.; Dringen, R.
Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons
Cell Growth Differ.
5
1159-1171
1994
Mus musculus (P53668), Mus musculus
Manually annotated by BRENDA team
Cheng, A.K.; Robertson, E.J.
The murine LIM-kinase gene (limk) encodes a novel serine threonine kinase expressed predominantly in trophoblast giant cells and the developing nervous system
Mech. Dev.
52
187-197
1995
Mus musculus (P53668)
Manually annotated by BRENDA team
Martindale, D.W.; Wilson, M.D.; Wang, D.; Burke, R.D.; Chen, X.; Duronio, V.; Koop, B.F.
Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23
Mamm. Genome
11
890-898
2000
Mus musculus (P53668)
Manually annotated by BRENDA team
Proschel, C.; Blouin, M.J.; Gutowski, N.J.; Ludwig, R.; Noble, M.
Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro
Oncogene
11
1271-1281
1995
Mus musculus (P53668)
Manually annotated by BRENDA team
Dong, L.Q.; Zhang, R.B.; Langlais, P.; He, H.; Clark, M.; Zhu, L.; Liu, F.
Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta
J. Biol. Chem.
274
8117-8122
1999
Mus musculus (Q9Z2A0), Mus musculus
Manually annotated by BRENDA team
Leong, M.L.; Maiyar, A.C.; Kim, B.; O'Keeffe, B.A.; Firestone, G.L.
Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells
J. Biol. Chem.
278
5871-5882
2003
Mus musculus (Q9WVC6)
Manually annotated by BRENDA team
Brodbeck, D.; Hill, M.M.; Hemmings, B.A.
Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain
J. Biol. Chem.
276
29550-29558
2001
Mus musculus (Q9WUA6), Mus musculus, Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team
Brodbeck, D.; Cron, P.; Hemmings, B.A.
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
J. Biol. Chem.
274
9133-9136
1999
Mus musculus (Q9WUA6), Mus musculus, Homo sapiens (Q9Y243), Homo sapiens
Manually annotated by BRENDA team
Alcorta, D.A.; Crews, C.M.; Sweet, L.J.; Bankston, L.; Jones, S.W.; Erikson, R.L.
Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase
Mol. Cell. Biol.
9
3850-3859
1989
Gallus gallus (P18652), Gallus gallus, Mus musculus (P18653), Mus musculus
Manually annotated by BRENDA team
Bellacosa, A.; Franke, T.F.; Gonzalez-Portal, M.E.; Datta, K.; Taguchi, T.; Gardner, J.; Cheng, J.Q.; Testa, J.R.; Tsichlis, P.N.
Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications
Oncogene
8
745-754
1993
Mus musculus (P31750), Mus musculus
Manually annotated by BRENDA team
Groenen, P.J.; Wansink, D.G.; Coerwinkel, M.; van den Broek, W.; Jansen, G.; Wieringa, B.
Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties
Hum. Mol. Genet.
9
605-616
2000
Mus musculus (P54265), Mus musculus
Manually annotated by BRENDA team
Mahadevan, M.S.; Amemiya, C.; Jansen, G.; Sabourin, L.; Baird, S.; Neville, C.E.; Wormskamp, N.; Segers, B.; Batzer, M.; Lamerdin, J.; et al.
Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene
Hum. Mol. Genet.
2
299-304
1993
Mus musculus (P54265), Mus musculus, Homo sapiens (Q09013), Homo sapiens
Manually annotated by BRENDA team
Jansen, G.; Bartolomei, M.; Kalscheuer, V.; Merkx, G.; Wormskamp, N.; Mariman, E.; Smeets, D.; Ropers, H.H.; Wieringa, B.
No imprinting involved in the expression of DM-kinase mRNAs in mouse and human tissues
Hum. Mol. Genet.
2
1221-1227
1993
Mus musculus (P54265), Mus musculus
Manually annotated by BRENDA team
Jansen, G.; Mahadevan, M.; Amemiya, C.; Wormskamp, N.; Segers, B.; Hendriks, W.; O'Hoy, K.; Baird, S.; Sabourin, L.; Lennon, G.; et al.
Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs
Nat. Genet.
1
261-266
1992
Mus musculus (P54265), Mus musculus, Homo sapiens (Q09013), Homo sapiens
Manually annotated by BRENDA team
Altomare, D.A.; Guo, K.; Cheng, J.Q.; Sonoda, G.; Walsh, K.; Testa, J.R.
Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene
Oncogene
11
1055-1060
1995
Mus musculus (Q60823), Mus musculus
Manually annotated by BRENDA team
Matthews, S.A.; Rozengurt, E.; Cantrell, D.
Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu
J. Biol. Chem.
274
26543-26549
1999
Mus musculus (Q62101)
Manually annotated by BRENDA team
Valverde, A.M.; Sinnett-Smith, J.; Van Lint, J.; Rozengurt, E.
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain
Proc. Natl. Acad. Sci. USA
91
8572-8576
1994
Mus musculus (Q62101)
Manually annotated by BRENDA team
Kispert, A.; Stoger, R.J.; Caparros, M.; Herrmann, B.G.
The mouse Rsk3 gene maps to the Leh66 elements carrying the t-complex responder Tcr
Mamm. Genome
10
794-802
1999
Mus musculus (Q9WUT3)
Manually annotated by BRENDA team
Shima, H.; Pende, M.; Chen, Y.; Fumagalli, S.; Thomas, G.; Kozma, S.C.
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
EMBO J.
17
6649-6659
1998
Mus musculus (Q9Z1M4)
Manually annotated by BRENDA team
Sanchez, Y.; Wong, C.; Thoma, R.S.; Richman, R.; Wu, Z.; Piwnica-Worms, H.; Elledge, S.J.
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
Science
277
1497-1501
1997
Homo sapiens (O14757), Homo sapiens, Mus musculus (O35280)
Manually annotated by BRENDA team
Flaggs, G.; Plug, A.W.; Dunks, K.M.; Mundt, K.E.; Ford, J.C.; Quiggle, M.R.; Taylor, E.M.; Westphal, C.H.; Ashley, T.; Hoekstra, M.F.; Carr, A.M.
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
Curr. Biol.
7
977-986
1997
Homo sapiens (O14757), Mus musculus (O35280)
Manually annotated by BRENDA team
Tomoda, T.; Bhatt, R.S.; Kuroyanagi, H.; Shirasawa, T.; Hatten, M.E.
A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons
Neuron
24
833-846
1999
Mus musculus (O70405), Mus musculus
Manually annotated by BRENDA team
Yan, J.; Kuroyanagi, H.; Kuroiwa, A.; Matsuda, Y.; Tokumitsu, H.; Tomoda, T.; Shirasawa, T.; Muramatsu, M.
Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51
Biochem. Biophys. Res. Commun.
246
222-227
1998
Mus musculus (O70405), Mus musculus
Manually annotated by BRENDA team
Laverty, H.G.; Wilson, J.B.
Murine CASK is disrupted in a sex-linked cleft palate mouse mutant
Genomics
53
29-41
1998
Mus musculus (O70589), Mus musculus
Manually annotated by BRENDA team
Gardner, H.P.; Wertheim, G.B.; Ha, S.I.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Marquis, S.T.; Chodosh, L.A.
Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase
Genomics
63
46-59
2000
Mus musculus (O88866)
Manually annotated by BRENDA team
Korobko, I.V.; Kabishev, A.A.; Kiselev, S.L.
Identification of the new protein kinase specifically transcribed in mouse tumors with high metastatic potential
Dokl. Akad. Nauk
354
554-556
1997
Mus musculus (O88866)
Manually annotated by BRENDA team
Matsuoka, S.; Huang, M.; Elledge, S.J.
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
Science
282
1893-1897
1998
Homo sapiens (O96017), Mus musculus (Q9Z265)
Manually annotated by BRENDA team
Burgess, H.A.; Martinez, S.; Reiner, O.
KIAA0369, doublecortin-like kinase, is expressed during brain development
J. Neurosci. Res.
58
567-575
1999
Mus musculus (Q9JLM8), Mus musculus
Manually annotated by BRENDA team
Kusuda, J.; Hirai, M.; Tanuma, R.; Hashimoto, K.
cDNA cloning and chromosome mapping of the mouse casein kinase I epsilon gene (Csnk1e)
Cytogenet. Cell Genet.
87
99-101
1999
Mus musculus (Q9JMK2), Mus musculus
Manually annotated by BRENDA team
Orlandini, M.; Semplici, F.; Ferruzzi, R.; Meggio, F.; Pinna, L.A.; Oliviero, S.
Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation
J. Biol. Chem.
273
21291-21297
1998
Mus musculus (O54833), Mus musculus
Manually annotated by BRENDA team
Seldin, D.C.; Leder, P.
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle
Science
267
894-897
1995
Mus musculus (Q60737), Mus musculus
Manually annotated by BRENDA team
Xu, X.; Rich, E.S., Jr.; Seldin, D.C.
Murine protein kinase CK2 alpha: cDNA and genomic cloning and chromosomal mapping
Genomics
48
79-86
1998
Mus musculus (O54833), Mus musculus
Manually annotated by BRENDA team
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (P97343), Mus musculus (Q61136), Mus musculus (Q99PW4)
Manually annotated by BRENDA team
Johnston, A.M.; Naselli, G.; Gonez, L.J.; Martin, R.M.; Harrison, L.C.; DeAizpurua, H.J.
SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
Oncogene
19
4290-4297
2000
Rattus norvegicus (O88506), Homo sapiens (Q9UEW8), Mus musculus (Q9Z1W9)
Manually annotated by BRENDA team
Burbelo, P.D.; Kozak, C.A.; Finegold, A.A.; Hall, A.; Pirone, D.M.
Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes
Gene
232
209-215
1999
Mus musculus (O88643), Mus musculus (Q61036), Mus musculus
Manually annotated by BRENDA team
Bagrodia, S.; Taylor, S.J.; Creasy, C.L.; Chernoff, J.; Cerione, R.A.
Identification of a mouse p21Cdc42/Rac activated kinase
J. Biol. Chem.
270
22731-22737
1995
Mus musculus (Q61036), Mus musculus
Manually annotated by BRENDA team
Tate, P.; Lee, M.; Tweedie, S.; Skarnes, W.C.; Bickmore, W.A.
Capturing novel mouse genes encoding chromosomal and other nuclear proteins
J. Cell Sci.
111
2575-2585
1998
Mus musculus (Q61136), Mus musculus
Manually annotated by BRENDA team
Gross, T.; Lutzelberger, M.; Weigmann, H.; Klingenhoff, A.; Shenoy, S.; Kaufer, N.F.
Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue
Nucleic Acids Res.
25
1028-1035
1997
Homo sapiens (Q13523), Mus musculus (Q61136)
Manually annotated by BRENDA team
Maucuer, A.; Ozon, S.; Manceau, V.; Gavet, O.; Lawler, S.; Curmi, P.; Sobel, A.
KIS is a protein kinase with an RNA recognition motif
J. Biol. Chem.
272
23151-23156
1997
Mus musculus (P97343), Rattus norvegicus (Q63285)
Manually annotated by BRENDA team
Maucuer, A.; Camonis, J.H.; Sobel, A.
Stathmin interaction with a putative kinase and coiled-coil-forming protein domains
Proc. Natl. Acad. Sci. USA
92
3100-3104
1995
Mus musculus (P97343)
Manually annotated by BRENDA team
Wang, Y.; Hofmann, T.G.; Runkel, L.; Haaf, T.; Schaller, H.; Debatin, K.; Hug, H.
Isolation and characterization of cDNAs for the protein kinase HIPK2
Biochim. Biophys. Acta
1518
168-172
2001
Homo sapiens (Q9H2X6), Homo sapiens, Mus musculus (Q9QZR5), Mus musculus
Manually annotated by BRENDA team
Wang, W.; Link, V.; Green, J.M.
Identification and cloning of a CD43-associated serine/threonine kinase
Cell. Immunol.
205
34-39
2000
Mus musculus (Q9QZR5)
Manually annotated by BRENDA team
Kim, Y.H.; Choi, C.Y.; Kim, Y.
Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1
Proc. Natl. Acad. Sci. USA
96
12350-12355
1999
Mus musculus (Q9QZR5), Mus musculus
Manually annotated by BRENDA team
Kim, Y.H.; Choi, C.Y.; Lee, S.J.; Conti, M.A.; Kim, Y.
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors
J. Biol. Chem.
273
25875-25879
1998
Mus musculus (Q9QZR5)
Manually annotated by BRENDA team
Taylor, S.S.; McKeon, F.
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
Cell
89
727-735
1997
Mus musculus (O08901)
Manually annotated by BRENDA team
Pangilinan, F.; Li, Q.; Weaver, T.; Lewis, B.C.; Dang, C.V.; Spencer, F.
Mammalian BUB1 protein kinases: map positions and in vivo expression
Genomics
46
379-388
1997
Mus musculus (O08901), Homo sapiens (O43683)
Manually annotated by BRENDA team
Davenport, J.W.; Fernandes, E.R.; Harris, L.D.; Neale, G.A.; Goorha, R.
The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner
Genomics
55
113-117
1999
Homo sapiens (O60566), Homo sapiens, Mus musculus (Q9Z1S0), Mus musculus
Manually annotated by BRENDA team
Ohta, S.; Takeuchi, M.; Deguchi, M.; Tsuji, T.; Gahara, Y.; Nagata, K.
A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway
Biochem. J.
350
395-404
2000
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Rattus norvegicus (P57760)
Manually annotated by BRENDA team
Berson, A.E.; Young, C.; Morrison, S.L.; Fujii, G.H.; Sheung, J.; Wu, B.; Bolen, J.B.; Burkhardt, A.L.
Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase
Biochem. Biophys. Res. Commun.
259
533-538
1999
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Mus musculus
Manually annotated by BRENDA team
Stairs, D.B.; Perry Gardner, H.; Ha, S.I.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Chodosh, L.A.
Cloning and characterization of Krct, a member of a novel subfamily of serine/threonine kinases
Hum. Mol. Genet.
7
2157-2166
1998
Mus musculus (O88697), Mus musculus
Manually annotated by BRENDA team
Ligos, J.M.; Gerwin, N.; Fernandez, P.; Gutierrez-Ramos, J.C.; Bernad, A.
Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases
Biochem. Biophys. Res. Commun.
249
380-384
1998
Homo sapiens (O75716), Homo sapiens, Mus musculus (O88697), Mus musculus
Manually annotated by BRENDA team
Kurioka, K.; Nakagawa, K.; Denda, K.; Miyazawa, K.; Kitamura, N.
Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo
Biochim. Biophys. Acta
1443
275-284
1998
Mus musculus (O88697), Mus musculus
Manually annotated by BRENDA team
Kim, J.M.; Sato, N.; Yamada, M.; Arai, K.; Masai, H.
Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for S. cerevisiae Cdc7-related kinase
J. Biol. Chem.
273
23248-23257
1998
Mus musculus (Q9Z0H0), Mus musculus
Manually annotated by BRENDA team
Wang, P.J.; McCarrey, J.R.; Yang, F.; Page, D.C.
An abundance of X-linked genes expressed in spermatogonia
Nat. Genet.
27
422-426
2001
Mus musculus (Q99mw1), Homo sapiens (Q9BXU1)
Manually annotated by BRENDA team
Phin, S.; Kupferwasser, D.; Lam, J.; Lee-Fruman, K.K.
Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1
Biochem. J.
373
583-591
2003
Mus musculus
Manually annotated by BRENDA team
Bucko-Justyna, M.; Lipinski, L.; Burgering, B.M.; Trzeciak, L.
Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling
FEBS J.
272
6310-6323
2005
Mus musculus
Manually annotated by BRENDA team
Mukai, H.
The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC
J. Biochem.
133
17-27
2003
Asteroidea, Bos taurus, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus laevis
Manually annotated by BRENDA team
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Spiridonov, N.A.; Wong, L.; Zerfas, P.M.; Starost, M.F.; Pack, S.D.; Paweletz, C.P.; Johnson, G.R.
Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility
Mol. Cell. Biol.
25
4250-4261
2005
Mus musculus (Q925K9), Mus musculus, Homo sapiens (Q9BXA6), Homo sapiens
Manually annotated by BRENDA team
Cho, Y.Y.; Yao, K.; Kim, H.G.; Kang, B.S.; Zheng, D.; Bode, A.M.; Dong, Z.
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation
Cancer Res.
67
8104-8112
2007
Mus musculus
Manually annotated by BRENDA team
Wei, Y.; Fu, G.; Hu, H.; Lin, G.; Yang, J.; Guo, J.; Zhu, Q.; Yu, L.
Isolation and characterization of mouse testis specific serine/threonine kinase 5 possessing four alternatively spliced variants
J. Biochem. Mol. Biol.
40
749-756
2007
Mus musculus (A3QQQ9), Mus musculus (A3QQR1), Mus musculus (A9P6P7), Mus musculus (A9P6P9), Mus musculus
Manually annotated by BRENDA team
Brauksiepe, B.; Mujica, A.O.; Herrmann, H.; Schmidt, E.R.
The Serine/threonine kinase Stk33 exhibits autophosphorylation and phosphorylates the intermediate filament protein Vimentin
BMC Biochem.
9
25
2008
Mus musculus (Q924X7)
Manually annotated by BRENDA team
Garland, P.; Quraishe, S.; French, P.; OConnor, V.
Expression of the MAST family of serine/threonine kinases
Brain Res.
1195
12-19
2008
Mus musculus (Q3U214), Mus musculus (Q60592), Mus musculus (Q811L6), Mus musculus (Q9R1L5)
Manually annotated by BRENDA team
Li, L.F.; Liao, S.K.; Huang, C.C.; Hung, M.J.; Quinn, D.A.
Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment
Crit. Care
12
R103
2008
Mus musculus (Q60823)
Manually annotated by BRENDA team
Jung, H.; Seong, H.A.; Ha, H.
Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr838 phosphorylation
J. Biol. Chem.
283
34541-34553
2008
Mus musculus (Q61846), Mus musculus
Manually annotated by BRENDA team
Mao, K.; Kobayashi, S.; Jaffer, Z.M.; Huang, Y.; Volden, P.; Chernoff, J.; Liang, Q.
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes
J. Mol. Cell. Cardiol.
44
429-434
2008
Mus musculus (P07564), Rattus norvegicus (P35465)
Manually annotated by BRENDA team
Duffy, P.; Schmandke, A.; Schmandke, A.; Sigworth, J.; Narumiya, S.; Cafferty, W.B.; Strittmatter, S.M.
Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord
J. Neurosci.
29
15266-15276
2009
Mus musculus
Manually annotated by BRENDA team
Densham, R.M.; ONeill, E.; Munro, J.; Koenig, I.; Anderson, K.; Kolch, W.; Olson, M.F.
MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability
Mol. Cell. Biol.
29
6380-6390
2009
Mus musculus
Manually annotated by BRENDA team
Cao, Y.; Li, H.; Liu, H.; Zheng, C.; Ji, H.; Liu, X.
The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
Cell Res.
20
99-108
2010
Mus musculus
Manually annotated by BRENDA team
Seong, H.; Ha, H.
Murine protein serine-threonine kinase 38 activates p53 function through Ser 15 phosphorylation
J. Biol. Chem.
287
20797-20810
2012
Mus musculus
Manually annotated by BRENDA team
Shang, P.; Baarends, W.; Hoogerbrugge, J.; Ooms, M.; Van Cappellen, W.; De Jong, A.; Dohle, G.; Van Eenennaam, H.; Gossen, J.; Grootegoed, J.
Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases
J. Cell Sci.
123
331-339
2010
Mus musculus
Manually annotated by BRENDA team
Kim, J.; Son, J.; Jang, Y.; Lee, D.; Kang, N.; Jung, S.; Heo, Y.; Lee, K.; Lee, H.
Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase, inhibits tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells
J. Pharmacol. Exp. Ther.
338
1013-1022
2011
Mus musculus
Manually annotated by BRENDA team
Wei, Y.; Wang, X.; Fu, G.; Yu, L.
Testis specific serine/threonine kinase 4 (Tssk4) maintains its kinase activity by phosphorylating itself at Thr-197
Mol. Biol. Rep.
40
439-447
2013
Mus musculus, Mus musculus (A3QQQ9)
Manually annotated by BRENDA team
Fu, G.; Wei, Y.; Wang, X.; Yu, L.
Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117
Biosci. Biotechnol. Biochem.
80
1088-1094
2016
Mus musculus (Q9D411)
Manually annotated by BRENDA team
Millon-Fremillon, A.; Brunner, M.; Abed, N.; Collomb, E.; Ribba, A.; Block, M.; Albiges-Rizo, C.; Bouvard, D.
Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1alpha) negatively regulates beta1 integrins
J. Biol. Chem.
288
20248-20260
2013
Mus musculus
Manually annotated by BRENDA team
Schael, S.; Nuechel, J.; Mueller, S.; Petermann, P.; Kormann, J.; Perez-Otano, I.; Martinez, S.; Paulsson, M.; Plomann, M.
Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation
J. Biol. Chem.
288
9303-9312
2013
Mus musculus
Manually annotated by BRENDA team
Greer, Y.; Westlake, C.; Gao, B.; Bharti, K.; Shiba, Y.; Xavier, C.; Pazour, G.; Yang, Y.; Rubin, J.
Casein kinase 1delta functions at the centrosome and Golgi to promote ciliogenesis
Mol. Biol. Cell
25
1629-1640
2014
Mus musculus
Manually annotated by BRENDA team
Fu, G.; Wei, Y.; Wang, X.; Yu, L.
Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117
Biosci. Biotechnol. Biochem.
80
1088-1094
2016
Mus musculus (Q9D411)
-
Manually annotated by BRENDA team
Schael, S.; Nuechel, J.; Mueller, S.; Petermann, P.; Kormann, J.; Perez-Otano, I.; Martinez, S.; Paulsson, M.; Plomann, M.
Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation
J. Biol. Chem.
288
9303-9312
2013
Mus musculus (O54833), Rattus norvegicus (P19139)
-
Manually annotated by BRENDA team
Greer, Y.; Westlake, C.; Gao, B.; Bharti, K.; Shiba, Y.; Xavier, C.; Pazour, G.; Yang, Y.; Rubin, J.
Casein kinase 1delta functions at the centrosome and Golgi to promote ciliogenesis
Mol. Biol. Cell
25
1629-1640
2014
Homo sapiens (P48730), Mus musculus (Q9DC28)
-
Manually annotated by BRENDA team
An, N.; Lin, Y.; Mahajan, S.; Kellner, J.; Wang, Y.; Li, Z.; Kraft, A.; Kang, Y.
Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells
Stem Cells
31
1202-1212
2013
Mus musculus (P06803), Mus musculus, Homo sapiens (P11309), Homo sapiens
Manually annotated by BRENDA team
Akizuki, K.; Toyama, T.; Yamashita, M.; Sugiyama, Y.; Ishida, A.; Kameshita, I.; Sueyoshi, N.
Facile preparation of highly active casein kinase 1 using Escherichia coli constitutively expressing lambda phosphatase
Anal. Biochem.
549
99-106
2018
Mus musculus (Q8BK63), Mus musculus (Q9DC28), Mus musculus (Q9JMK2)
Manually annotated by BRENDA team
Lv, Y.; Chen, J.; Hu, J.; Qian, Y.; Kong, Y.; Fu, L.
Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the Rho-associated kinase 1/myosin light chains/actin pathway
Front. Pharmacol.
11
598592
2020
Mus musculus
Manually annotated by BRENDA team
Kearney, A.; Cooke, K.; Norris, D.; Zadoorian, A.; Krycer, J.; Fazakerley, D.; Burchfield, J.; James, D.
Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes
J. Biol. Chem.
294
16729-16739
2019
Mus musculus (Q60823)
Manually annotated by BRENDA team
Halvarsson, C.; Eliasson, P.; Joensson, J.
Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function
PLoS ONE
12
e0171714
2017
Mus musculus (Q9Z2A0), Mus musculus
Manually annotated by BRENDA team
Eng, G.; Ediso, E.; Virshup, D.
Site-specific phosphorylation of casein kinase 1 delta (CK1delta) regulates its activity towards the circadian regulator PER2
PLoS ONE
12
e0177834
2017
Mus musculus
Manually annotated by BRENDA team