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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Homo sapiens and UniProt Accession O14965
for references in articles please use BRENDA:EC2.7.11.1
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EC Tree 2 Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
IUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
- 2.7.11.1
- jnk
- mapks
-
signal-regulated
- rapamycin
- agonist
- necrosis
- endothelial
- cardiac
- mtor
- parkinsonism
- caspase-3
- metastasis
- bcl-2
- synaptic
- cyclin
- alzheimer
- cyclase
- hippocampal
- forskolin
- sirnas
- neurodegenerative
- autophosphorylation
-
neuroprotective
- creb
-
phorbol
- tumorigenesis
- cardiomyocytes
- wortmannin
- pten
-
cyclin-dependent
- ventricular
- gtpases
- myocytes
- cytoskeleton
-
adenylyl
- nf-kappab
- myocardial
- ischemia
-
dominant-negative
- nmda
-
hyperphosphorylation
-
postsynaptic
-
anti-apoptotic
- src
- phosphoprotein
- isoproterenol
- rhoa
- staurosporine
-
tensin
-
l-type
- medicine
- pharmacology
- molecular biology
- drug development
Reaction Schemes
show+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
AKT
AKT1
AMH type II receptor
-
-
-
-
Anti-sigma B factor rsbT
-
-
-
-
AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
-
casein kinase 2
casein kinase I
casein kinase II
casein kinase-2
CDC25 suppressing protein kinase
-
-
-
-
Cdc7 kinase
Cell division cycle 2-like
-
-
-
-
Chk1
CK-2
-
-
-
-
CK1delta
CK2
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CKII
CLP-36 interacting kinase
-
-
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DAP-kinase
DNA-PKcs
DNPK1
-
-
-
-
dSTPK61
-
-
-
-
G11 protein
-
-
-
-
glycogen synthase kinase 3
GSK3
hARK1
-
-
-
-
histone kinase
-
-
-
-
homeodomain-interacting protein kinase 2
hPDK1
-
-
-
-
Hpr kinase
-
-
-
-
hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
-
hydroxyalkyl-protein kinase
-
-
-
-
Kinase interacting with stathmin
-
-
-
-
kinase, casein (phosphorylating)
-
-
-
-
kinase, protamine (phosphorylating)
-
-
-
-
kinase, protein (phosphorylating)
-
-
-
-
kinase, protein, A (phosphorylating)
-
-
-
-
kinase, protein, C (phosphorylating)
-
-
-
-
Lymphocyte-oriented kinase
-
-
-
-
M phase-specific cdc2 kinase
-
-
-
-
mitogen-activated S6 kinase
-
-
-
-
mitotic checkpoint serine/threonine-protein kinase BUB1
-
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
-
mPDK1
-
-
-
-
MPSK
-
-
-
-
myotonin-protein kinase
-
Myristoylated and palmitoylated serine-threonine kinase
-
-
-
-
NDR1
NY-REN-55 antigen
-
-
-
-
P-CIP2
-
-
-
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
-
p82 kinase
-
-
-
-
PDK1
pEg2
-
-
-
-
phosphoinositide 3-kinase
phosphorylase b kinase kinase
-
-
-
-
Phototropin
-
-
-
-
PI3K
Pim-2h
-
-
-
-
PKA
PKB
PkB kinase
-
-
-
-
pp39-mos
-
-
-
-
Pre-mRNA protein kinase
-
-
-
-
protamine kinase
-
-
-
-
protein glutamyl kinase
-
-
-
-
protein kinase (phosphorylating)
-
-
-
-
Protein kinase B kinase
-
-
-
-
protein kinase CK2
Protein kinase Krct
-
-
-
-
Protein kinase MST
-
-
-
-
protein kinase p58
-
-
-
-
Protein kinase PKL12
-
-
-
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
-
protein-aspartyl kinase
-
-
-
-
protein-cysteine kinase
-
-
-
-
protein-serine kinase
-
-
-
-
protein-serine/threonine kinase
-
-
-
-
PRP4 kinase
-
-
-
-
PRP4 pre-mRNA processing factor 4 homolog
-
-
-
-
PSK-H1
-
-
-
-
RAC-alpha serine/threonine kinase
-
RAC-gamma serine/threonine protein kinase
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
-
ratAurA
-
-
-
-
ribosomal protein S6 kinase II
-
-
-
-
ribosomal S6 protein kinase
-
-
-
-
RP1 protein
-
-
-
-
S-receptor kinase
-
-
-
-
S6K1
serine kinase
-
-
-
-
serine protein kinase
-
-
-
-
serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine-threonine kinase
serine/threonine kinase
Serine/threonine kinase 15
-
-
-
-
Serine/threonine kinase Ayk1
-
-
-
-
serine/threonine protein kinase
serine/threonine protein kinase R (PKR)-like endoplasmic reticulum kinase
-
serine/threonine-protein kinase
Serine/threonine-protein kinase NRK2
-
-
-
-
Serine/threonine-protein kinase NYD-SPK
-
-
-
-
serine/threonine-protein kinase Sgk
-
SRK
-
-
-
-
Ste20-like kinase
-
-
-
-
STE20-like kinase MST1
-
-
-
-
STE20-like kinase MST2
-
-
-
-
STE20-like kinase MST3
-
-
-
-
STK11
Switch protein/serine kinase
-
-
-
-
T-antigen kinase
-
-
-
-
threonine-specific protein kinase
-
-
-
-
Twitchin kinase
-
-
-
-
type-2 casein kinase
-
-
-
-
additional information
casein kinase 2
-
-
-
-
casein kinase I
-
-
-
-
casein kinase II
-
-
-
-
casein kinase-2
-
-
-
-
CK2
-
-
-
-
CK2
-
-
CKII
-
-
-
-
DAP-kinase
-
-
-
-
DNA-PKcs
-
-
-
-
PKA
-
-
-
-
protein kinase CK2
-
-
-
-
serine/threonine kinase
-
-
-
-
serine/threonine protein kinase
-
-
-
-
additional information
-
PKD2 belongs to the PKD family of serine/threonine kinases
additional information
-
the enzyme belongs to the CKI family of serine/threonine protein kinases
additional information
TSSK5 is a member of the testis-specific serine/threonine kinase family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
catalytic mechanism and regulation of PKN
-
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
the CK1 family shows a strong preference both in vitro and in vivo for primed, pre-phosphorylated substrates. CK1 family members prefer acidic substrates in vitro, most notably those with acidic residues in the N-3 position, e.g. D-X-X-S/T. The most effective motif contains a phospho-residue in the N-3 position, such as pS/pT-X-X-S/T, where pS/pT refers to a phospho-serine or phospho-threonine, X refers to any amino acid, and the underlined residues refer to the target site
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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CAS REGISTRY NUMBER
COMMENTARY
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 4E-BP1 protein
ADP + phosphorylated 4E-BP1 protein
-
Substrates: -
Products: -
Products: -
?
ATP + ABCA1 NBD1-R1 protein
ADP + phosphorylated ABCA1 NBD1-R1 protein
-
Substrates: substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 1 and cytoplasmic domain R1 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli, phosphorylation at T1242, T1243, and S1255
Products: -
Products: -
?
ATP + ABCA1 NBD2-R2 protein
ADP + phosphorylated ABCA1 NBD2-R2 protein
-
Substrates: substrate protein is a recombinant construct of wild-type and mutant nucleotide binding domain 2 and cytoplasmic domain R2 of ATP-binding cassette transporter protein A1 expressed in Escherichia coli
Products: -
Products: -
?
ATP + Ac-RPRAASF
ADP + Ac-Ac-RPRAApSF
Substrates: an efficient fluorescence assay for serine/threonine kinases using a peptide array is developed. Assay is based on chemical reactions specific to phosphoserine and phosphothreonine residues, that is, base-mediated beta-elimination of the phosphate group and subsequent Michael addition of a thiol-containing fluorescent reagent. This procedure enables the covalent introduction of a fluorescent moiety into the phosphorylated peptide. Novel fluorescent reagents are designed for this purpose and synthesized
Products: -
Products: -
?
ATP + acetyl-CoA carboxylase
ADP + phosphorylated acetyl-CoA carboxylase
Substrates: phosphorylation and inactivation
Products: -
Products: -
?
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
-
Substrates: i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
Products: -
Products: -
?
ATP + AIB1 protein
ADP + phosphorylated AIB1 protein
-
Substrates: phosphorylation at S601 by isozyme CK1delta
Products: -
Products: -
?
ATP + alpha-casein
ADP + phosphorylated alpha-casein
-
Substrates: casein kinase 1alpha
Products: -
Products: -
?
ATP + AMP-activated protein kinase alpha1
ADP + phospho-AMP-activated protein kinase
Substrates: phosphorylation of Ser485 at subunit alpha1 and of Ser491 at subunit alpha2
Products: -
Products: -
?
ATP + ataxin-3 protein
ADP + phosphorylated ataxin-3 protein
-
Substrates: phosphorylation at serines 340 and 352
Products: -
Products: -
?
ATP + axin
ADP + phosphorylated axin
Substrates: glycogen synthase kinase 3
Products: -
Products: -
?
ATP + BAF170
ADP + phosphorylated BAF170
-
Substrates: BAF170 is a hSWI/SNF protein that contains one Akt consensus site
Products: -
Products: -
?
ATP + beta-hydroxy beta-methylglutaryl-coenzyme A reductase
ADP + phosphorylated beta-hydroxy beta-methylglutaryl-coenzyme A reductase
Substrates: phosphorylation and inactivation
Products: -
Products: -
?
ATP + calmodulin
ADP + phosphorylated calmodulin
-
Substrates: phosphorylation by isozyme CK1alpha
Products: -
Products: -
?
ATP + CARMA1 protein
ADP + phosphorylated CARMA1
-
Substrates: i.e. CARD11 protein, phosphorylation at S608 by isozyme CK1alpha
Products: -
Products: -
?
ATP + Cdc25C
ADP + ?
Substrates: Chk2 phosphorylated Cdc25C on Ser216
Products: -
Products: -
?
ATP + Cdc42Hs
ADP + ?
Substrates: PAK4 interacts only with the activated form of Cdc42Hs through its GTPase-binding domain
Products: -
Products: -
?
ATP + Cdk2 interacting protein
ADP + phosphorylated Cdk2 interacting protein
-
Substrates: -
Products: -
Products: -
?
ATP + cell division cycle 7
ADP + phosphorylated cell division cycle 7
-
Substrates: -
Products: -
Products: -
?
ATP + Dnmt1 protein
ADP + phosphorylated Dnmt1 protein
-
Substrates: phosphorylation at S147 by isozymes CK1delta and CK1epsilon
Products: -
Products: -
?
ATP + FADD protein
ADP + phosphorylated FADD protein
-
Substrates: phosphorylation at S194 by isozyme CK1alpha
Products: -
Products: -
?
ATP + Gli1 protein
ADP + phosphorylated Gli1 protein
Substrates: low activity
Products: -
Products: -
?
ATP + Gli2 protein
ADP + phosphorylated Gli2 protein
Substrates: high activity
Products: -
Products: -
?
ATP + Gli3 protein
ADP + phosphorylated Gli3 protein
Substrates: low activity
Products: -
Products: -
?
ATP + glycogen synthase kinase-3 (GSK-3) fusion protein
ADP + phosphorylated- glycogen synthase kinase-3 fusion protein
Substrates: -
Products: -
Products: -
?
ATP + granulocyte macrophage colony stimulating factor receptor
ADP + phospho-granulocyte macrophage colony stimulating factor receptor
ATP + histone H2A
ADP + phosphorylated histone H2A
Substrates: recombinant human substrate, substrate of SSTK
Products: -
Products: -
?
ATP + histone H2AX
ADP + phosphorylated histone H2AX
Substrates: recombinant human substrate, substrate of SSTK
Products: -
Products: -
?
ATP + histone H2B
ADP + phosphorylated histone H2B
Substrates: recombinant human substrate, substrate of SSTK
Products: -
Products: -
?
ATP + histone H4
ADP + phosphorylated histone H4
Substrates: recombinant substrate from Xenopus laevis, substrate of SSTK
Products: -
Products: -
?
ATP + IFNAR1 protein
ADP + phosphorylated IFNAR1 protein
-
Substrates: phosphorylation at S535 by isozyme CK1alpha
Products: -
Products: -
?
ATP + IKKalpha protein
ADP + phosphorylated IKKalpha protein
-
Substrates: -
Products: -
Products: -
?
ATP + KKRNRRLSVA
ADP + KKRNRRL-phosphoserine-VA
-
Substrates: peptide substrate of NDR1
Products: -
Products: -
?
ATP + KKRNRRLSVA
ADP + phosphorylated-KKRNRRLSVA
Substrates: -
Products: -
Products: -
?
ATP + KLP10A protein
ADP + phosphorylated KLP10A protein
-
Substrates: phosphorylation at S573 by isozyme CK1alpha
Products: -
Products: -
?
ATP + L-seryl-[Eukaryotic initiation factor 2]
ADP + H+ + O-phospho-L-seryl-[Eukaryotic initiation factor 2]
Substrates: -
Products: -
Products: -
?
ATP + M3-muscarnic receptor
ADP + phosphorylated M3-muscarnic receptor
-
Substrates: -
Products: -
Products: -
?
ATP + MARCKS protein
ADP + MARCKS phosphoprotein
-
Substrates: isozyme PKNalpha
Products: -
Products: -
?
ATP + MCM2
ADP + ?
Substrates: wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro
Products: -
Products: -
?
ATP + MCM3
ADP + ?
Substrates: wild-type huCdc7 protein expressed in COS7 cells phosphorylates MCM2 and MCM3 proteins in vitro
Products: -
Products: -
?
ATP + non-structural protein 2
ADP + phospho-non-structural protein 2
-
Substrates: non-structural protein 2 from bluetongue virus (BTV)
Products: -
Products: -
?
ATP + NS5A protein
ADP + phosphorylated NS5A protein
-
Substrates: recombinant NS5A expressed in Sf9 cells, substrate is a hepatitis C virus protein playing a critical role in virus replication and conferring interferon resistance to the virus, the viral protein is phosphorylated by several STE or AGC type protein kinases CK2, AKT1, SGK1, 90S6K, STE, phosphorylation patterns, overview
Products: -
Products: -
?
ATP + OTUB1
ADP + phospho-OTUB1
-
Substrates: OTUB1 is a tumor domain protease, phosphorylation at Ser16, in GSDSEGVN
Products: -
Products: -
?
ATP + OTUB1 protein
ADP + phosphorylated OTUB1 protein
-
Substrates: phosphorylation at serine 16
Products: -
Products: -
?
ATP + OTUD5 protein
ADP + phosphorylated OTUD5 protein
-
Substrates: phosphorylation at serine 177
Products: -
Products: -
?
ATP + peptide LRRKtide
ADP + phosphorylated peptide LRRKtide
-
Substrates: high activity towards the peptidic substrate LRRKtide
Products: -
Products: -
?
ATP + PHLPP1 protein
ADP + phosphorylated PHLPP1 protein
-
Substrates: phosphorylation at T851 by isozyme CK1alpha
Products: -
Products: -
?
ATP + phosphoglycogen synthase peptide 2
ADP + phosphorylated phosphoglycogen synthase peptide 2
-
Substrates: -
Products: -
Products: -
?
ATP + PKD2 protein
ADP + phosphorylated PKD2 protein
-
Substrates: phosphorylation at S244 by isozymes CK1alpha, CK1delta, and CK1epsilon
Products: -
Products: -
?
ATP + protein
ADP + protein tyrosine phosphate
Substrates: phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes
Products: -
Products: -
?
ATP + protein INI
ADP + phosphorylated INI
-
Substrates: INI is a hSWI/SNF protein
Products: -
Products: -
?
ATP + protein kinase C
ADP + phosphorylated protein kinase C
-
Substrates: isozyme PKNalpha
Products: -
Products: -
?
ATP + protein LRP6
ADP + phosphorylated protein LRP6
-
Substrates: CKIgamma
Products: -
Products: -
?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
-
Substrates: CKIepsilon
Products: -
Products: -
?
ATP + rapamycin
ADP + phospho-rapamycin
Substrates: -
Products: -
Products: -
?
ATP + Rec8 protein
ADP + phosphorylated Rec8 protein
-
Substrates: phosphorylation at S412 by isozyme CK1delta and CK1epsilon, and at S400, S402, S404, S410, T414, and S416
Products: -
Products: -
?
ATP + RRRDDDSDDD
ADP + RRRDDDphosphoSDDD
-
Substrates: a CK2-specific synthetic peptide substrate
Products: -
Products: -
?
ATP + RRRLSSLRA
ADP + RRRLSpSLRA
-
Substrates: enzyme activities are determined by measuring initial velocities for His6-S6K1aII(DELTA AID)-T389E catalyzed phosphorylation of a commercially available S6K/RSK model peptide substrate 1 (S6K1-Tide, RRRLSSLRA)
Products: -
Products: -
?
ATP + RSRSRSRSRSRSPPPVSK
ADP + phosphorylated RSRSRSRSRSRSPPPVSK
-
Substrates: SC35-derived peptide 180-197, recombinant GSK-3beta
Products: -
Products: -
?
ATP + SLR1 protein
ADP + phosphorylated SLR1 protein
-
Substrates: phosphorylation at S196 and SS510
Products: -
Products: -
?
ATP + Snail protein
ADP + phosphorylated Snail protein
-
Substrates: phosphorylation at S104 and S07 by isozyme CK1epsilon
Products: -
Products: -
?
ATP + SR protein
ADP + ?
Substrates: enzyme plays a role as a co-repressor for homeodomain transcription factors
Products: -
Products: -
?
ATP + SSH1L protein
ADP + SSH1L phosphoprotein
-
Substrates: PKD1 phosphorylates the SSH enzyme SSH1L at serine 978
Products: -
Products: -
?
ATP + TRPM4
ADP + phospho-TRPM4
-
Substrates: i.e. transient receptor potential melastatin-like 4, phosphorylation at Ser839
Products: -
Products: -
?
ATP + TRPM4 protein
ADP + phosphorylated TRPM4 protein
-
Substrates: phosphorylation at serine 839
Products: -
Products: -
?
ATP + Varicella-Zoster viral gB protein
ADP + phosphorylated Varicella-Zoster viral gB protein
-
Substrates: phosphorylation at S34 in the sequence QSEDIT
Products: -
Products: -
?
ATP + vimentin
ADP + phosphorylated vimentin
-
Substrates: isozyme PKNalpha
Products: -
Products: -
?
ATP + YAP protein
ADP + phosphorylated YAP protein
-
Substrates: phosphorylation at S384 and S387 by isozymes CK1delta and CK1epsilon
Products: -
Products: -
?
ATP + [FRAT-2 protein]
ADP + phosphorylated [FRAT-2 protein]
-
Substrates: i.e. frequently rearranged in advanced T-cell lymphoma protein 2, phosphorylation by GSK3beta
Products: -
Products: -
?
ATP + [M3 muscarinic acetylcholine receptor]
ADP + phospho-[M3 muscarinic acetylcholine receptor]
-
Substrates: recombinant substrate expressed in HEK-293 and CHO cells, casein kinase 1alpha
Products: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene
Products: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: the enzyme is required for function of the spindle assembly checkpoint
Products: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis
Products: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: hBUBR1 may regulate multiple functions that include the kinetochore and the spindle midzone
Products: -
Products: -
?
ATP + a protein
ADP + a phosphoprotein
Substrates: hBub1 is an important component of the spindle checkpoint pathway. hBub1 expression is restricted to proliferating cells and appears to be involved in regulating cell cycle progression
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ATP + a protein
ADP + a phosphoprotein
Substrates: Bub1 is required for binding Bub3
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ATP + a protein
ADP + a phosphoprotein
Substrates: huCdc7 may regulate processes of DNA replication by modulating MCM functions
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ATP + a protein
ADP + a phosphoprotein
Substrates: HsCdc7 may phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication
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ATP + AKAP450
ADP + phospho-AKAP450
Substrates: wild-type substrate and GFP-tagged AKAP450 fragment containing the CK1delta-binding site
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ATP + BAF155
ADP + phosphorylated BAF155
-
Substrates: BAF155 is a hSWI/SNF protein that contains three Akt consensus sites, phosphorylation site analysis using recombinant full-length and truncated substrate versions, overview
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ATP + beta-catenin
ADP + phosphorylated beta-catenin
Substrates: glycogen synthase kinase 3
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ATP + beta-catenin
ADP + phosphorylated beta-catenin
-
Substrates: phosphorylation at Ser45, priming GSK3beta phosphorylation
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ATP + beta-catenin
ADP + phosphorylated beta-catenin
-
Substrates: -
Products: by isozymes CK1delta and CK1epsilon
Products: by isozymes CK1delta and CK1epsilon
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ATP + CDC25A
ADP + phospho-CDC25A
Substrates: STK38 phosphorylates CDC25A at Ser76
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ATP + CDC25A
ADP + phospho-CDC25A
Substrates: recombinantly expressed full-length wild-type CDC25A or CDC25A mutants S124A and S76A are used as substrates. STK38 phosphorylates wild-type CDC25A and mutant S124A at Ser76, it shows no activity with the S76A mutant
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ATP + Cdc25A
ADP + phosphorylated Cdc25A
-
Substrates: phosphorylation at S79 and S82 by isozyme CK1alpha
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ATP + Cdc25A
ADP + phosphorylated Cdc25A
Substrates: phosphorylation site Ser76
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ATP + CREB
ADP + phosphorylated CREB
Substrates: phosphorylation by TSSK5 at Ser133 stimulates the cAMP responsive element/cAMP responsive element binding protein CRE/CREB responsive pathway in recombinant HEK293 cells
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ATP + CREB
ADP + phosphorylated CREB
Substrates: i.e. cAMP responsive element binding protein, phosphorylation by TSSK5 at Ser133, no activity with CREB S133A mutant
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ATP + Daxx
ADP + phosphorylated Daxx
-
Substrates: Daxx is a protein acting in TGF-beta-induced JNK activation and in apoptosis
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ATP + Daxx
ADP + phosphorylated Daxx
-
Substrates: recombinant Daxx expressed as GST-fusion protein in Escherichia coli
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ATP + geminin
ADP + phosphorylated geminin
-
Substrates: a cell cycle regulatory protein
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ATP + Gli protein
ADP + phosphorylated Gli protein
-
Substrates: the Gli proteins are important in regulation of Hedgehog signaling, overview
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ATP + Gli protein
ADP + phosphorylated Gli protein
-
Substrates: -
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ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
Substrates: glycogen synthase kinase 3 is involved in the insulin signaling pathway regulating glycogen synthesis via glycogen synthase antagonizing insulin
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ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
Substrates: glycogen synthase kinase 3
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ATP + glycogen synthase kinase 3
ADP + phosphorylated glycogen synthase kinase 3
Substrates: PKB protein kinase
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ATP + glycogen synthase kinase 3
ADP + phosphorylated glycogen synthase kinase 3
Substrates: PKB protein kinase, phosphorylation at S21 and S9
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ATP + granulocyte macrophage colony stimulating factor receptor
ADP + phospho-granulocyte macrophage colony stimulating factor receptor
Substrates: -
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ATP + granulocyte macrophage colony stimulating factor receptor
ADP + phospho-granulocyte macrophage colony stimulating factor receptor
Substrates: Ser585 phosphorylation in the cytoplasmic domain
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ATP + histone H1
ADP + phosphorylated histone H1
Substrates: -
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ATP + histone H1
ADP + phosphorylated histone H1
Substrates: -
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ATP + histone H1
ADP + phosphorylated histone H1
-
Substrates: PDK2
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ATP + histone H1
ADP + phosphorylated histone H1
Substrates: substrate from calf, substrate of SSTK
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ATP + hypoxia-inducible factor-1
ADP + phosphorylated hypoxia-inducible factor-1
-
Substrates: i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview
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ATP + hypoxia-inducible factor-1
ADP + phosphorylated hypoxia-inducible factor-1
-
Substrates: i.e. HIF-1
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ATP + interleukin 3
ADP + phospho-interleukin-3
Substrates: -
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ATP + interleukin 3
ADP + phospho-interleukin-3
Substrates: Ser585 phosphorylation in the cytoplasmic domain
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ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala
ADP + ?
Substrates: -
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ATP + Lys-Lys-Phe-Asn-Arg-Thr-Leu-Ser-Val-Ala
ADP + ?
-
Substrates: -
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ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
Substrates: -
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ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
Substrates: -
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ATP + phospholipase D
ADP + phosphorylated phospholipase D
-
Substrates: CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity
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ATP + phospholipase D
ADP + phosphorylated phospholipase D
-
Substrates: -
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ATP + PKB protein kinase
ADP + phosphorylated PKB protein kinase
Substrates: PDK1 kinase, phosphorylates Thr308 and Ser473, which is required for activation of PKB
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ATP + PKB protein kinase
ADP + phosphorylated PKB protein kinase
Substrates: PDK1 kinase
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ATP + procaspase-2
ADP + phosphorylated procaspase-2
-
Substrates: phosphorylation of procaspase-2 by CK2 prevents the activation of caspase activity by inhibiting the dimerization of procaspase-2, CK2 activity is involved in the direct regulation of the caspase-8 pathway, where it can control caspase-8 activity through the phosphorylation of ARC or by preventing the ability of caspase-8 to cleave its target Bid
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ATP + procaspase-2
ADP + phosphorylated procaspase-2
-
Substrates: -
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ATP + protein
ADP + phosphoprotein
Substrates: autophosphorylates exclusively serines within its COOH-terminal region in an intermolecular fashion
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ATP + protein
ADP + phosphoprotein
Substrates: minimum sequence required for efficient phosphorylation is Xaa-Xaa-Hyd-Xaa-Arg-Xaa-Xaa-Ser-Xaa-Xaa, where Hyd is a bulky hydrophobic residue (in decreasing order), Phe, Leu, Val, Ala, MAPKAP kinase-2 can not tolerate a proline residue at position n + 1
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ATP + protein
ADP + phosphoprotein
Substrates: the enzyme is an effector for Cdc42Hs and is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
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ATP + protein
ADP + phosphoprotein
Substrates: PAK3 may be critical for human cognitive function
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ATP + protein
ADP + phosphoprotein
Substrates: the enzyme regulates the structure of the actin cytoskeleton in mammalian cells, and may serve as an effector for effector for Cdc42 and Rac1 in proll motility
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ATP + protein
ADP + phosphoprotein
Substrates: hPAK1 is a GTPase effector controlling a downstream MAP kinase pathway. PAK kinase plays a key part in linking extracellular signals from membrane components, such as receptor-associated G proteins and Rho-related GTPases, to nuclear responses, such as transcriptional activation
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ATP + SC35
ADP + phosphorylated SC35
-
Substrates: substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors
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ATP + SC35
ADP + phosphorylated SC35
-
Substrates: substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, recombinant GSK-3beta
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ATP + SF2/ASF
ADP + phosphorylated SF2/ASF
Substrates: SF2/ASF is a human SR splicing factor, phosphorylation in the RS domain
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ATP + SIV/17E-Fr Nef protein
ADP + phosphorylated SIV/17E-Fr Nef protein
-
Substrates: phosphorylation at Ser12, the protein kinase CK2 associates with the Nef proteins from the Human immunodeficiency virus and the macrophage-tropic neurovirulent Simian immunodeficiency virus clone, SIV/17E-Fr, the Nef protein play important roles in viral disease progression
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ATP + SIV/17E-Fr Nef protein
ADP + phosphorylated SIV/17E-Fr Nef protein
-
Substrates: phosphorylation at Ser12, no or poor activity with SIV/17E-Fr Nef protein mutants S12P and D15A, respectively, in transfected 293T cells, Asp15 of the substrate is important for phosphorylation
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ATP + Src protein
ADP + phosphorylated Src protein
Substrates: -
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ATP + Src protein
ADP + phosphorylated Src protein
Substrates: recombinant Src expressed in HEK-293 cells, specific phosphorylation of Ser70, no activity with S70A Src mutant
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ATP + tau protein
ADP + phosphorylated tau protein
-
Substrates: tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview
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ATP + tau protein
ADP + phosphorylated tau protein
-
Substrates: determination of several phosphorylation sites, e.g. Ser258, Ser289, Ser262, and Ser356 within the microtubule-binding repeats or at Ser184 and Ser185 of the central region, for casein kinase I, casein kinase 2, and glycogen synthase kinase-3beta in insoluble tau, PHF-tau, extracted from Alzheimer brain and of tau from control healthy brain by mass spectrometry, overview
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ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
Substrates: tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins
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ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
Substrates: phosphorylation of primed and unprimed sites by GSK3beta, wild-type and recombinant tau, recombinant GSK3beta S9A
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ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
Substrates: phosphorylation of tau, especially at the primed epitope T231 negatively regulates tau-microtubule interactions, different effects of phosphorylation on primed T231 and unprimed S396/S404 epitopes of tau, overview
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ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
Substrates: -
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ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
Substrates: substrate of GSK3beta in brain
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ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
Substrates: substrate of GSK-3 in brain
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ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
Substrates: phosphorylation at the C-terminus, lower activity with C-terminally truncated tau D421 compared to the wild-type tau, the truncated tau protein forms sarcosyl-insoluble aggregates
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casein + ATP
phosphorylated casein + ADP
Substrates: -
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additional information
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Substrates: guanylate kinase activity
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additional information
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Substrates: LIMK may be involved in developmental or oncogenic processes through interactions with LIM-containing proteins
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additional information
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Substrates: LIMK1 may be particularly relevant when explaining cognitive defects observed in WS patients
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additional information
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Substrates: LIM-kinase 1 hemizygosity is implicated in impaired visuospatial constructive cognition
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additional information
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Substrates: deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
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additional information
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Substrates: AKT1 gene is not a major contributor to susceptibility to type II diabetes mellitus in Ashkenazi Jews
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additional information
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-
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Substrates: AKT1 gene is not a major contributor to susceptibility to type II diabetes mellitus in Ashkenazi Jews
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additional information
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Substrates: K+-channel activation by all three isoforms of serum-dependent and glucocorticoid-dependent protein kinase SGK
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additional information
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-
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Substrates: K+-channel activation by all three isoforms of serum-dependent and glucocorticoid-dependent protein kinase SGK
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additional information
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Substrates: the enzyme acts in concert with Akt to propagate the effects of PI3K activation within the nucleus and to mediate the biological outputs of PI3K signaling, including cell survival and cell cycle progression
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additional information
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Substrates: transcript levels are strongly altered during anisotonic and isotonic cell volume changes
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additional information
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-
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Substrates: transcript levels are strongly altered during anisotonic and isotonic cell volume changes
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additional information
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Substrates: AKT2 may contribute to the pathogenesis of ovarian carcinomas
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additional information
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Substrates: T-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients
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additional information
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Substrates: T-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients
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additional information
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Substrates: enzyme may have a role in the development of mental symptoms in severe cases of myotonic dystrophy
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additional information
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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additional information
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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additional information
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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additional information
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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additional information
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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additional information
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Substrates: ribosomal S6-kinase RSK4 is commonly deleted in patients with complex X-linked mental retardation, RSK4 plays a role in normal neuronal development. RSK4 is completely deleted in eight patients with the contiguous gene syndrome including MRX, partially deleted in a patient with DFN3 and present in patients with an Xq21 deletion and normal intellectual abilities
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additional information
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Substrates: decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
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additional information
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Substrates: inherited defects in insulin-stimulated activation of muscle glycogen synthesis in patients with insulin-resistant NIDDM may be located further upstream of ISPK-1 in the insulin action cascade
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additional information
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Substrates: inherited defects in insulin-stimulated activation of muscle glycogen synthesis in patients with insulin-resistant NIDDM may be located further upstream of ISPK-1 in the insulin action cascade
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additional information
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Substrates: Chk1 acts as an integrator for Atm and Atr signals and may be involved in monitoring the processing of meiotic recombination CHK1 gene is a candidate tumor suppressor gene
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additional information
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Substrates: kinase functions downstream of ATM protein in the cellular response to DNA damage
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additional information
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Substrates: kinase functions downstream of ATM protein in the cellular response to DNA damage
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additional information
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Substrates: in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry
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additional information
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Substrates: in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry
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additional information
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Substrates: in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis
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additional information
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Substrates: heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors
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additional information
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Substrates: likely role for DCAMKL1 transmembrane protein in developing and adult brain, possibly in a pathway of cortical development
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additional information
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Substrates: likely role for DCAMKL1 transmembrane protein in developing and adult brain, possibly in a pathway of cortical development
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additional information
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Substrates: mutations of STK11 cause Peutz-Jeghers syndrome
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additional information
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Substrates: Peutz-Jeghers syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer, germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome
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additional information
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Substrates: Peutz-Jeghers syndrome is the first cancer-susceptibility syndrome to be identified that is due to inactivating mutations in a protein kinase, STK11
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additional information
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Substrates: NH2-terminal region of hPRP4 may play regulatory roles under an unidentified signal transduction pathway through Clk1
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additional information
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Substrates: enzyme is involved in pre-mRNA splicing
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additional information
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Substrates: calmodulin-binding region of titin can play a regulatory role for the enzyme
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additional information
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Substrates: calmodulin-binding region of titin can play a regulatory role for the enzyme
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additional information
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Substrates: enzyme may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock
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additional information
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Substrates: enzyme may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock
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additional information
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Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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additional information
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Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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additional information
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Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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additional information
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Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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additional information
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Substrates: regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, PKNalpha is involved in vesicle transport in the endoplasmic reticulum, PKNalpha is cleaved by caspase-3 or related proteases in apoptotic Jurkat and U-937 cells contributing to signal transduction, PKN interacts with papillomaviral oncoproteins being involved in tumorigenesis, overview
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additional information
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Substrates: HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in hepatoma cells, HIPK2 triggers promyelotic leukemia nuclear body disruption and release of Daxx
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additional information
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Substrates: PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview
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additional information
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Substrates: serine/threonine protein kinase is SSTK essential for male fertility
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additional information
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Substrates: serine/threonine protein kinase is SSTK essential for male fertility
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additional information
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Substrates: the enzyme participates in Alzheimer's disease
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additional information
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Substrates: GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview
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additional information
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Substrates: phosphorylated tau is important in cytoskeleton assembly
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additional information
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Substrates: naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits
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additional information
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Substrates: GSK3beta works coordinatedly with PKA, EC 2.7.11.11, on tau phosphorylation
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additional information
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Substrates: mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase
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additional information
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Substrates: enzyme performs autophosphorylation, PKN binds several associated proteins via its ACC domain, i.e. RhoA, a small GTPase, which binds to the ACC domain of PKNalpha forming a catalytic active site
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additional information
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Substrates: CKII phosphorylates serine or threonine residues with an acidic amino acid in the +2 or +3 position
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additional information
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Substrates: substrate specificity of PDK1, PDK1 binds the hydrophobic motif of substrates via its PIF pocket, GSK3 substrates need to bind tightly to the enzyme for phosphorylation
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additional information
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Substrates: substrate ABC transporter protein structure, phosphorylation of the ABCA1 transporter reduces its flippase activity, overview
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additional information
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Substrates: PKD2 performs autophosphorylation
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additional information
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Substrates: substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signate proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity
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additional information
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Substrates: substrate specificity with diverse peptide substrates, overview, SSTK forms stable complexes with heat shock signate proteins HSP90-1beta, HSC70, and HSP70-1, which seems to be necessary for activity
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additional information
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Substrates: substrate specificity of GSK3beta
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additional information
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Substrates: GSK3beta catalyzes tau phosphorylation in brain, EC 2.7.11.26, but phosphorylation of glycogen synthase and other proteins in different tissues
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additional information
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Substrates: GSK3beta catalyzes tau phosphorylation, EC 2.7.11.26, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues
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additional information
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Substrates: GSK3beta catalyzes tau phosphorylation, EC 2.7.11.1, in brain, but phosphorylation of glycogen synthase and other proteins in different tissues
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additional information
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Substrates: GSK-3alphabeta catalyzes tau phosphorylation in brain, but phosphorylation of glycogen synthase and other proteins, EC 2.7.11.1, in different tissues
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additional information
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-
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Substrates: GSK3beta catalyzes tau phosphorylation in brain, EC 2.7.11.26, but phosphorylation of glycogen synthase and other proteins in different tissues
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?
additional information
?
-
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Substrates: NDR1 performs autophosphorylation at S281, T444, and T74 dependent on intracellular Ca2+
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?
additional information
?
-
Substrates: the enzyme is involved in the inflammation cascade in intestine and colon epithelium
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?
additional information
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Substrates: multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase
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?
additional information
?
-
-
Substrates: CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview
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?
additional information
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-
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Substrates: the enzyme inhibits NF-kappaB activity via interaction with the leucine-rich repeat domain of the Salmonella enterica serovar typhimurium-derived effector SspH1 in infected intestine-407 cells, overview
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?
additional information
?
-
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Substrates: members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, overview
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?
additional information
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-
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Substrates: high CK2 activity occurs in solid tumors due to growth-related functions and to suppression of cellular apoptosis, nuclear localization of domain CK2alpha is associated with high-grade tumors and a poor prognostic factor, overview
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additional information
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-
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Substrates: CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview
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additional information
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Substrates: CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed
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additional information
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Substrates: CK2 plays a role in the protection of cells from apoptosis via the regulation of tumor suppressor and oncogene activity and stability, e.g. in the NF-kappaB or the Wnt signaling pathways, molecular mechanisms, detailed overview, CK2 activity is linked to Her-2/neu oncogene, which is overexpressed in 30% of breast cancers, regulation of apoptotic machinery by CK2 and its anti-apoptotic effect, overview, role of CK2 in chromosomal DNA strand break repair and the maintenance of genomic integrity, mutational study, overview
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?
additional information
?
-
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Substrates: protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview
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?
additional information
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-
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Substrates: the catalytic kinase domain, residues 561-942, of PKN1 is active with out the regulatory domain
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additional information
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-
-
Substrates: members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, however, no Akt consensus sequences are found on BRG1, hBrm, BAF60, BAF57, or on INI1, overview
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?
additional information
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-
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Substrates: CK2 contains a consensus sequence in which a carboxylic acid side chain at position n+3 relative to the target serine/threonine residue plays a crucial role for activity, CK2 shows a broad substrate specificity of diverse proteins
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additional information
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Substrates: the pleiotropic protein kinase CK2 possesses many protein interaction sites
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additional information
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Substrates: enzyme binds both soluble inositol polyphosphates and inositol phospholipids
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additional information
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Substrates: ULK3 shows autophosphorylation activity
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additional information
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Substrates: ULK3 shows autophosphorylation activity
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additional information
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Substrates: CK1 exhibits autophosphorylation activity
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additional information
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Substrates: the enzyme is also active as lipid kinase generating phosphatidylinositol 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate from 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
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additional information
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Substrates: phosphoinositide 3-kinase (PI3K) is a dual specificity kinase that is able to phosphorylate both lipid and protein substrates. In addition to their lipid kinase activity, all members of the class 1 PI3K family also possess intrinsic protein kinase activity
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additional information
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: the p110alpha catalytic subunit of PI3K can directly phosphorylate Ser585 of the GM-CSF and IL-3 receptors
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additional information
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Substrates: the enzyme does not phosphorylate Thr172, but suppresses its phosphorylation
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additional information
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Substrates: the FATC domain reacts with membrane mimetics, titration analysis, overview
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additional information
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Substrates: the FATC domain reacts with membrane mimetics, titration analysis, overview
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additional information
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Substrates: the FATC domain reacts with membrane mimetics, titration analysis, overview
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additional information
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Substrates: the FATC domain reacts with membrane mimetics, titration analysis, overview
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additional information
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Substrates: OTUB1 is a bona fide substrate for CK2
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additional information
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Substrates: TRPM4 phosphorylation site determination by peptide mapping
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 4E-BP1 protein
ADP + phosphorylated 4E-BP1 protein
-
Substrates: -
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?
ATP + adenomatous polyposis coli protein
ADP + phosphorylated adenomatous polyposis coli protein
-
Substrates: i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon
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?
ATP + alpha-casein
ADP + phosphorylated alpha-casein
-
Substrates: casein kinase 1alpha
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?
ATP + AMP-activated protein kinase alpha1
ADP + phospho-AMP-activated protein kinase
Substrates: phosphorylation of Ser485 at subunit alpha1 and of Ser491 at subunit alpha2
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?
ATP + ataxin-3 protein
ADP + phosphorylated ataxin-3 protein
-
Substrates: phosphorylation at serines 340 and 352
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?
ATP + axin
ADP + phosphorylated axin
Substrates: glycogen synthase kinase 3
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?
ATP + CDC25A
ADP + phospho-CDC25A
Substrates: STK38 phosphorylates CDC25A at Ser76
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?
ATP + Cdc25A
ADP + phosphorylated Cdc25A
Substrates: phosphorylation site Ser76
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?
ATP + Cdk2 interacting protein
ADP + phosphorylated Cdk2 interacting protein
-
Substrates: -
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?
ATP + cell division cycle 7
ADP + phosphorylated cell division cycle 7
-
Substrates: -
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?
ATP + CREB
ADP + phosphorylated CREB
Substrates: phosphorylation by TSSK5 at Ser133 stimulates the cAMP responsive element/cAMP responsive element binding protein CRE/CREB responsive pathway in recombinant HEK293 cells
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?
ATP + Daxx
ADP + phosphorylated Daxx
-
Substrates: Daxx is a protein acting in TGF-beta-induced JNK activation and in apoptosis
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?
ATP + geminin
ADP + phosphorylated geminin
-
Substrates: a cell cycle regulatory protein
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?
ATP + Gli protein
ADP + phosphorylated Gli protein
-
Substrates: the Gli proteins are important in regulation of Hedgehog signaling, overview
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?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
Substrates: glycogen synthase kinase 3 is involved in the insulin signaling pathway regulating glycogen synthesis via glycogen synthase antagonizing insulin
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?
ATP + glycogen synthase kinase 3
ADP + phosphorylated glycogen synthase kinase 3
Substrates: PKB protein kinase
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?
ATP + granulocyte macrophage colony stimulating factor receptor
ADP + phospho-granulocyte macrophage colony stimulating factor receptor
Substrates: -
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?
ATP + hypoxia-inducible factor-1
ADP + phosphorylated hypoxia-inducible factor-1
-
Substrates: i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview
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?
ATP + IKKalpha protein
ADP + phosphorylated IKKalpha protein
-
Substrates: -
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?
ATP + interleukin 3
ADP + phospho-interleukin-3
Substrates: -
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?
ATP + L-seryl-[Eukaryotic initiation factor 2]
ADP + H+ + O-phospho-L-seryl-[Eukaryotic initiation factor 2]
Substrates: -
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?
ATP + M3-muscarnic receptor
ADP + phosphorylated M3-muscarnic receptor
-
Substrates: -
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?
ATP + OTUB1
ADP + phospho-OTUB1
-
Substrates: OTUB1 is a tumor domain protease, phosphorylation at Ser16, in GSDSEGVN
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?
ATP + OTUB1 protein
ADP + phosphorylated OTUB1 protein
-
Substrates: phosphorylation at serine 16
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?
ATP + OTUD5 protein
ADP + phosphorylated OTUD5 protein
-
Substrates: phosphorylation at serine 177
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?
ATP + peptide LRRKtide
ADP + phosphorylated peptide LRRKtide
-
Substrates: high activity towards the peptidic substrate LRRKtide
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?
ATP + phospholipase D
ADP + phosphorylated phospholipase D
-
Substrates: CKII is involved in 4beta-phorbol 12-myristate 13-acetate-induced phospholipase D activation, of PLD1 or PLD2 activity as well as basal PLD activity
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?
ATP + PKB protein kinase
ADP + phosphorylated PKB protein kinase
Substrates: PDK1 kinase, phosphorylates Thr308 and Ser473, which is required for activation of PKB
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?
ATP + procaspase-2
ADP + phosphorylated procaspase-2
-
Substrates: phosphorylation of procaspase-2 by CK2 prevents the activation of caspase activity by inhibiting the dimerization of procaspase-2, CK2 activity is involved in the direct regulation of the caspase-8 pathway, where it can control caspase-8 activity through the phosphorylation of ARC or by preventing the ability of caspase-8 to cleave its target Bid
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?
ATP + protein
ADP + protein tyrosine phosphate
Substrates: phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes
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?
ATP + protein LRP6
ADP + phosphorylated protein LRP6
-
Substrates: CKIgamma
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?
ATP + protein TCF3
ADP + phosphorylated protein TCF3
-
Substrates: CKIepsilon
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?
ATP + rapamycin
ADP + phospho-rapamycin
Substrates: -
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?
ATP + SC35
ADP + phosphorylated SC35
-
Substrates: substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors
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?
ATP + SIV/17E-Fr Nef protein
ADP + phosphorylated SIV/17E-Fr Nef protein
-
Substrates: phosphorylation at Ser12, the protein kinase CK2 associates with the Nef proteins from the Human immunodeficiency virus and the macrophage-tropic neurovirulent Simian immunodeficiency virus clone, SIV/17E-Fr, the Nef protein play important roles in viral disease progression
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?
ATP + SR protein
ADP + ?
Substrates: enzyme plays a role as a co-repressor for homeodomain transcription factors
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?
ATP + Src protein
ADP + phosphorylated Src protein
Substrates: -
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?
ATP + SSH1L protein
ADP + SSH1L phosphoprotein
-
Substrates: PKD1 phosphorylates the SSH enzyme SSH1L at serine 978
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?
ATP + tau protein
ADP + phosphorylated tau protein
-
Substrates: tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview
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?
ATP + TRPM4
ADP + phospho-TRPM4
-
Substrates: i.e. transient receptor potential melastatin-like 4, phosphorylation at Ser839
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?
ATP + TRPM4 protein
ADP + phosphorylated TRPM4 protein
-
Substrates: phosphorylation at serine 839
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?
ATP + [tau-protein]
ADP + O-phospho -[tau-protein]
-
Substrates: tau is primarily found in neurons, regulation of tau phosphorylation by GSK3beta via interaction with FRAT-1 and FRAT-2, i.e. frequently rearranged in advanced T-cell lymphoma proteins
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: the enzyme is required for function of the spindle assembly checkpoint
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: cell cycle-dependent expression, Bub1b has a putative destruction box that can target proteins for degradation by proteosomes during mitosis
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: hBUBR1 may regulate multiple functions that include the kinetochore and the spindle midzone
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: hBub1 is an important component of the spindle checkpoint pathway. hBub1 expression is restricted to proliferating cells and appears to be involved in regulating cell cycle progression
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: Bub1 is required for binding Bub3
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: huCdc7 may regulate processes of DNA replication by modulating MCM functions
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?
ATP + a protein
ADP + a phosphoprotein
Substrates: HsCdc7 may phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication
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?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
Substrates: glycogen synthase kinase 3
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?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
-
Substrates: phosphorylation at Ser45, priming GSK3beta phosphorylation
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?
ATP + protein
ADP + phosphoprotein
Substrates: the enzyme is an effector for Cdc42Hs and is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
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?
ATP + protein
ADP + phosphoprotein
Substrates: PAK3 may be critical for human cognitive function
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?
ATP + protein
ADP + phosphoprotein
Substrates: the enzyme regulates the structure of the actin cytoskeleton in mammalian cells, and may serve as an effector for effector for Cdc42 and Rac1 in proll motility
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?
ATP + protein
ADP + phosphoprotein
Substrates: hPAK1 is a GTPase effector controlling a downstream MAP kinase pathway. PAK kinase plays a key part in linking extracellular signals from membrane components, such as receptor-associated G proteins and Rho-related GTPases, to nuclear responses, such as transcriptional activation
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?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
Substrates: phosphorylation of tau, especially at the primed epitope T231 negatively regulates tau-microtubule interactions, different effects of phosphorylation on primed T231 and unprimed S396/S404 epitopes of tau, overview
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?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
-
Substrates: -
Products: -
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?
additional information
?
-
Substrates: LIMK may be involved in developmental or oncogenic processes through interactions with LIM-containing proteins
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?
additional information
?
-
Substrates: LIMK1 may be particularly relevant when explaining cognitive defects observed in WS patients
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?
additional information
?
-
Substrates: LIM-kinase 1 hemizygosity is implicated in impaired visuospatial constructive cognition
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?
additional information
?
-
Substrates: deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy
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?
additional information
?
-
Substrates: AKT1 gene is not a major contributor to susceptibility to type II diabetes mellitus in Ashkenazi Jews
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?
additional information
?
-
-
Substrates: AKT1 gene is not a major contributor to susceptibility to type II diabetes mellitus in Ashkenazi Jews
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?
additional information
?
-
Substrates: K+-channel activation by all three isoforms of serum-dependent and glucocorticoid-dependent protein kinase SGK
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?
additional information
?
-
-
Substrates: K+-channel activation by all three isoforms of serum-dependent and glucocorticoid-dependent protein kinase SGK
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?
additional information
?
-
Substrates: the enzyme acts in concert with Akt to propagate the effects of PI3K activation within the nucleus and to mediate the biological outputs of PI3K signaling, including cell survival and cell cycle progression
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?
additional information
?
-
Substrates: transcript levels are strongly altered during anisotonic and isotonic cell volume changes
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?
additional information
?
-
-
Substrates: transcript levels are strongly altered during anisotonic and isotonic cell volume changes
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?
additional information
?
-
Substrates: AKT2 may contribute to the pathogenesis of ovarian carcinomas
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?
additional information
?
-
Substrates: T-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients
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?
additional information
?
-
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Substrates: T-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern can be responsible for the mental status impairment observed in myotonic dystrophy patients
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?
additional information
?
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Substrates: enzyme may have a role in the development of mental symptoms in severe cases of myotonic dystrophy
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?
additional information
?
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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?
additional information
?
-
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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?
additional information
?
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
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?
additional information
?
-
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
Products: -
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?
additional information
?
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Substrates: mutations in the ribosomal S6 kinase (Rsk-2) gene are associated with Coffin-Lowry syndrome, an X-linked disorder characterized by facial dysmorphism, digit abnormalities and severe psychomotor retardation
Products: -
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?
additional information
?
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Substrates: ribosomal S6-kinase RSK4 is commonly deleted in patients with complex X-linked mental retardation, RSK4 plays a role in normal neuronal development. RSK4 is completely deleted in eight patients with the contiguous gene syndrome including MRX, partially deleted in a patient with DFN3 and present in patients with an Xq21 deletion and normal intellectual abilities
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?
additional information
?
-
Substrates: decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy
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?
additional information
?
-
Substrates: inherited defects in insulin-stimulated activation of muscle glycogen synthesis in patients with insulin-resistant NIDDM may be located further upstream of ISPK-1 in the insulin action cascade
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?
additional information
?
-
-
Substrates: inherited defects in insulin-stimulated activation of muscle glycogen synthesis in patients with insulin-resistant NIDDM may be located further upstream of ISPK-1 in the insulin action cascade
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?
additional information
?
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Substrates: Chk1 acts as an integrator for Atm and Atr signals and may be involved in monitoring the processing of meiotic recombination CHK1 gene is a candidate tumor suppressor gene
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?
additional information
?
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Substrates: kinase functions downstream of ATM protein in the cellular response to DNA damage
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?
additional information
?
-
-
Substrates: kinase functions downstream of ATM protein in the cellular response to DNA damage
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?
additional information
?
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Substrates: in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry
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?
additional information
?
-
-
Substrates: in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry
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?
additional information
?
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Substrates: in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis
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?
additional information
?
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Substrates: heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors
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?
additional information
?
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Substrates: likely role for DCAMKL1 transmembrane protein in developing and adult brain, possibly in a pathway of cortical development
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?
additional information
?
-
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Substrates: likely role for DCAMKL1 transmembrane protein in developing and adult brain, possibly in a pathway of cortical development
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?
additional information
?
-
Substrates: mutations of STK11 cause Peutz-Jeghers syndrome
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?
additional information
?
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Substrates: Peutz-Jeghers syndrome is an autosomal-dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer, germline mutations in STK11, probably in conjunction with acquired genetic defects of the second allele in somatic cells, cause the manifestations of PJ syndrome
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?
additional information
?
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Substrates: Peutz-Jeghers syndrome is the first cancer-susceptibility syndrome to be identified that is due to inactivating mutations in a protein kinase, STK11
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?
additional information
?
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Substrates: NH2-terminal region of hPRP4 may play regulatory roles under an unidentified signal transduction pathway through Clk1
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?
additional information
?
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Substrates: enzyme is involved in pre-mRNA splicing
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?
additional information
?
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Substrates: calmodulin-binding region of titin can play a regulatory role for the enzyme
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?
additional information
?
-
-
Substrates: calmodulin-binding region of titin can play a regulatory role for the enzyme
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?
additional information
?
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Substrates: enzyme may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock
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additional information
?
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Substrates: enzyme may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock
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additional information
?
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Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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?
additional information
?
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Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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?
additional information
?
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Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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?
additional information
?
-
-
Substrates: Nek2 protein is almost undetectable during G1 but accumulates progressively throughout S, reaching maximal levels in late G2, may function at the onset of mitosis
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?
additional information
?
-
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Substrates: regulation mechanism and biological function of PKN, PKNalpha is involved in insulin-induced actin cytoskeleton reorganization and cell adhesion, overview, PKNalpha is involved in vesicle transport in the endoplasmic reticulum, PKNalpha is cleaved by caspase-3 or related proteases in apoptotic Jurkat and U-937 cells contributing to signal transduction, PKN interacts with papillomaviral oncoproteins being involved in tumorigenesis, overview
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Substrates: HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in hepatoma cells, HIPK2 triggers promyelotic leukemia nuclear body disruption and release of Daxx
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additional information
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Substrates: PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview
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additional information
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Substrates: serine/threonine protein kinase is SSTK essential for male fertility
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additional information
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Substrates: serine/threonine protein kinase is SSTK essential for male fertility
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Substrates: the enzyme participates in Alzheimer's disease
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additional information
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Substrates: GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview
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additional information
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Substrates: phosphorylated tau is important in cytoskeleton assembly
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Substrates: naturally occurring V717I mutation of the amyloid precursor protein APP in a CT100 fragment of organisms with Alzheimer's disease leads to augmented age-dependent tau phosphorylation, followed by increased activation status of mitogen-activated protein kinase family members, e.g. ERK1/2, p38, and c-Jun NH2-terminal kinase, compared to the wild-type organism, naturally occurring V337M mutation of tau protein of patients suffering Alzheimer's disease leads to age-dependent memory deficits
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Substrates: GSK3beta works coordinatedly with PKA, EC 2.7.11.11, on tau phosphorylation
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additional information
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Substrates: mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase
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Substrates: the enzyme is involved in the inflammation cascade in intestine and colon epithelium
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additional information
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Substrates: multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase
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Substrates: CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview
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Substrates: the enzyme inhibits NF-kappaB activity via interaction with the leucine-rich repeat domain of the Salmonella enterica serovar typhimurium-derived effector SspH1 in infected intestine-407 cells, overview
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Substrates: members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt, overview
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Substrates: high CK2 activity occurs in solid tumors due to growth-related functions and to suppression of cellular apoptosis, nuclear localization of domain CK2alpha is associated with high-grade tumors and a poor prognostic factor, overview
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Substrates: CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview
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Substrates: CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed
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Substrates: CK2 plays a role in the protection of cells from apoptosis via the regulation of tumor suppressor and oncogene activity and stability, e.g. in the NF-kappaB or the Wnt signaling pathways, molecular mechanisms, detailed overview, CK2 activity is linked to Her-2/neu oncogene, which is overexpressed in 30% of breast cancers, regulation of apoptotic machinery by CK2 and its anti-apoptotic effect, overview, role of CK2 in chromosomal DNA strand break repair and the maintenance of genomic integrity, mutational study, overview
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Substrates: enzyme binds both soluble inositol polyphosphates and inositol phospholipids
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Substrates: the enzyme is also active as lipid kinase generating phosphatidylinositol 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate from 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
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Substrates: phosphoinositide 3-kinase (PI3K) is a dual specificity kinase that is able to phosphorylate both lipid and protein substrates. In addition to their lipid kinase activity, all members of the class 1 PI3K family also possess intrinsic protein kinase activity
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: the PIKK family members phosphorylate proteins that regulate processes such as DNA repair, cell cycle progression, cellular senescence, and apoptosis
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additional information
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Substrates: OTUB1 is a bona fide substrate for CK2
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
Mn2+
Zn2+
-
bound to the zinc finger core at residues 105-147 and coordinated by Cys109, Cys114, Cys137 ans Cys140, of the beta subunit dimer
Ca2+
autophosphorylation activity is repressed upon addition of Ca2+/calmodulin
Mg2+
-
-
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-chloro-N-(4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)phenyl)benzamide
-
4-(2-(4-(2-(4-acetylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide
-
N-(2-chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide
-
N-(2-chlorophenyl)-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide
-
N-cyclopropyl-4-(5-fluoro-2-(4-hydroxyphenylamino)pyrimidin-4-ylamino)benzamide
-
(5Z)-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene)-2-thioxoimidazolidin-4-one
-
-
(S)-2-(2-aminopyrimidiny-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridinione
-
-
1,1'-[(5-chloropyrimidine-2,4-diyl)bis[azanediyl(3-methoxy-4,1-phenylene)piperazine-4,1-diyl]]di(ethan-1-one)
-
1-(6-[[4-(2,3-dihydro-1H-indol-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-5-methoxy-2,3-dihydro-1H-indol-1-yl)-2-(dimethylamino)ethan-1-one
-
1-(beta-D-2'-deoxyribofuranosyl)-4,5,6,7-tetrabromo-1H-benzimidazole
-
TDB, a cell-permeable selective inhibitor of CK2, inhibits the phosphorylation of OTUB1 at Ser16. In addition to CK2, TDB inhibits 3 other kinases, namely PIM1, CLK2 and DYRK1A, but none of these kinases phosphorylates OTUB1 in vitro
1-[3-methoxy-4-([6-[2-(propane-2-sulfonyl)anilino]-7H-purin-2-yl]amino)phenyl]piperidin-4-ol
-
2,3-difluoro-6-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
-
2-([5-bromo-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
-
2-([5-chloro-2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
-
2-([5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzene-1-sulfonamide
-
2-([5-chloro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzamide
-
2-([5-chloro-2-[4-(piperazin-1-yl)anilino]pyrimidin-4-yl]amino)-N-methylbenzamide
-
2-fluoro-6-([2-[(5-methoxy-1-[[4-(propan-2-yl)piperazin-1-yl]acetyl]-2,3-dihydro-1H-indol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
-
2-fluoro-6-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzoic acid
-
2-[(2-[4-chloro-2-methoxy-5-[(1-propylpiperidin-4-yl)oxy]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
-
2-[(2-[5-[(N,N-dimethylglycyl)(methyl)amino]-2-methoxy-4-methylanilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
-
2-[(2-[5-[(N,N-dimethylglycyl)amino]-2-methoxy-4-methylanilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluorobenzamide
-
2-[(2-[[1-(N,N-dimethylglycyl)-5-methoxy-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-N-methylbenzamide
-
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methylpyridine-2-carboxamide
-
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide
-
3-[(2-[[1-(N,N-dimethylglycyl)-6-methoxy-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]thiophene-2-carboxamide
-
3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate
-
-
4-fluoro-2-([2-[2-methoxy-4-(1-propylpiperidin-3-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
-
4-fluoro-2-([2-[2-methoxy-4-(1-propylpiperidin-4-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino)benzamide
-
4-hydroxy-trans-2-nonenal
-
i.e. 4-HNE, binds to the enzyme at Lys197 and inhibits its activity by 69% by inhibiting its posttranslational phosphorylation. 4-HNE binding has no effect on the association of LKB1 with its adaptor proteins, sterile-20-related adaptor and mouse protein 25
5-chloro-N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
-
5-chloro-N2-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-N4-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine
-
5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
-
5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine
-
5-fluoro-2-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
-
6,7-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)quinazolin-4-amine
elicits selective cytotoxic activity against the pancreas ductal adenocarcinoma (PANC-1) cell line
7,9-dimethyl-8-(prop-2-en-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine
-
-
AZD-6738
ATR inhibition sensitizes cancer cells to ionizing radiation and chemotherapeutics agents (cisplatin, carboplatin, gemcitabine and bendamustine)
Baicalin
-
one of the major compounds in the Chinese medical herb Scutellaria baicalensis, reduces enzyme expression and activity in badder cancer cells T24
Caffeine
ATM/ATR inhibition sensitizes cancer cells to ionizing radiation, nonspecific inhibitor for ATM and ATR
CP466722
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation, evokes defects in cell cycle checkpoints
ETP-46464
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
FAALS
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
idelalisib
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4(3H)-one, a PI3Kdelta inhibitor used to treat hematological malignancies. The inhibitor idelalisib is selective, noncovalent, reversible, and ATP-competitive, The compound binds reversibly and noncovalently to the p110delta subunit of the kinase, analysis of binding interactions that confer the potency and selectivity of idelalisib, overview. Idelalisib is a propeller-shaped inhibitor
indirubin-3'-monoxime
-
inhibition of AMPK, GSK3beta, S6K1, PKBalpha, PDK1, MAPKAP-K2
KU-55933
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation and DNA DSBs inducing chemotherapeutics agents
KU-59403
enzyme (ATM) inhibition significant chemosensitization and radiosensitization
KU-60019
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation
LAALS
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
lithium
-
after inhibition of GSK-3 in cortical neurons, the splicing factor SC35 is nuclearly redistributed and enriched in nuclear speckles and colocalizes with the kinase
N-ethyl-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-3a,6a-dihydro-1H-thieno[3,2-c]pyrazole-5-carboxamide
-
-
N-tert-butyl-3-([5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino)benzene-1-sulfonamide
-
N-[(2R)-2,3-dihydroxypropyl]-5-fluoro-2-[(2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide
-
N-[2-(4-fluorophenyl)ethyl]-5-[2-[(methylsulfonyl)amino]pyrimidin-4-yl]thiophene-2-carboxamide
-
-
N-[2-([5-chloro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)phenyl]methanesulfonamide
-
N-[2-([5-fluoro-2-[2-methoxy-4-(morpholin-4-yl)anilino]pyrimidin-4-yl]amino)phenyl]methanesulfonamide
-
N-[3-([2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino)phenyl]prop-2-enamide
-
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
-
N2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine
-
N2-[2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl]-N4-(quinolin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
NU6027
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
NVP-BEZ235
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
purvalanol
-
inhibition of AMPK, slight inhibition of GSK3beta and S6K1, PKBalpha
TAACS
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
TAALD
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
TAALE
-
five amino-acid peptide inhibitor that is directed toward a noncatalytic binding pocket and which disrupts the cdk2/cyklin E complex
Torin 2
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents non-specific inhibitor for ATR
VE-821
ATR inhibition, sensitizes cancer cells to ionizing radiation and chemotherapeutics agents, blocks activation of Chk1-dependent signaling pathway, enhances DNA damage in combination with cisplatin, arrests cell cycle in G2/M phase
VE-822
ATR inhibition sensitizes cancer cells to ionizing radiation and chemotherapeutics agents (cisplatin, oxaliplatin, gemcitabine, etoposide and SN38, the active metabolite of irinotecan)
enzastaurin
-
activation-related phosphorylation of Y216/Y276 is dramatically decreased following exposure to enzastaurin whereas the inhibitory phosphorylation of S21 is significantly up-regulated in glioma cells. GSK3 inhibition results in glioma cell death and reduced tumorigenicity
GSK2606414
PERK inhibition. Inhibition of PERKdependent, pro-adaptive unfolded protein response signaling pathway
GSK2656157
PERK inhibition. Inhibition of PERKdependent, pro-adaptive unfolded protein response signaling pathway
LY294002
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation, non-specific inhibitor for ATM
Wortmannin
enzyme (ATM) inhibition sensitizes cancer cells to ionizing radiation
additional information
-
PKN possesses an autoinhibitory site at the C-terminal C2 domain, which also binds activating arachidonic acid
-
additional information
GSK3 phosphorylation and inhibition by PKB protein kinase at S21 and S9
-
additional information
-
no inhibition of most serine/threonine kinases by roscovitine
-
additional information
-
the pleckstrin homology PH domain is a negative regulator of PKD2
-
additional information
-
phosphorylation of GSK3beta at S9 inhibits the enzyme
-
additional information
-
phosphorylation of GSK3beta at S9 inhibits the enzyme
-
additional information
-
phosphorylation of GSK3beta at S9 inhibits the enzyme
-
additional information
-
in vivo inhibition strategies in the mouse model, validation of CK2 targets identification of bona fide targets, overview
-
additional information
-
inhibition of GSK3 activity results in c-MYC activation, leading to the induction of Bax, Bim, DR4/DR5, and tumor necrosis factor-related apoptosis-inducing ligand expression and subsequent cytotoxicity. inhibition of GSK3 activity causes a dramatic decrease in intracellular nuclear factor-kappaB activity. Inhibition of GSK3 activity results in c-MYC-dependent glioma cell death through multiple mechanisms, all of which converge on the apoptotic pathways
-
additional information
expression of the pleckstrin homology of Akt1 has no significant impact on the ability of picomolar concentrations of cytokine to promote hemopoietic cell survival
-
additional information
the p110alpha-mediated increase in AMPK S485/491 phosphorylation is eliminated in the presence of the Akt inhibitor MK2206
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
arachidonic acid
-
activates in vitro, binds at the autoinhibitory site at the C-terminal C2-domain
cytokine
physiological concentrations of cytokine in the picomolar range were sufficient for activating the protein kinase activity of PI3K leading to Ser585 phosphorylation and hemopoietic cell survival but did not activate PI3K lipid kinase signaling or promote proliferation
-
FRAT-2
-
i.e. frequently rearranged in advanced T-cell lymphoma protein 2, activates phosphorylation of primed sites of tau protein about 8fold, no effect on unprimed site phosphorylation
-
gastrin
-
bind to the cysteine-rich domain C1b, activates, triggers nuclear accumulation of PPKD2 in AGS-B cancer cells
pervanadate
activation of Akt is associated with tyrosine phosphorylation of Akt
pyrvinium
-
an FDA-approved anthelmintic drug, a very potent allosteric activator of CKalpha that inhibits the Wnt/beta-catenin pathway by increasing phosphorylation and degradation of beta-catenin, along with other key substrates. it is specific for CK1alpha versus other forms of CK1
RhoA
-
small GTPase, binds to the ACC domain and activates isozymes PKNalpha and PRK2/PKNgamma/PAK-2
serum
activation of Akt is associated with tyrosine phosphorylation of Akt
-
Insulin
activated endogenous protein kinase B alpha12fold in L6 myotubes, while after transfection into 293 cells PKBalpha is activated 20fold and 50fold in response to insulin and IGF-1 respectively. In both cells, the activation of PKBalpha is accompanied by its phosphorylation at Thr308 and Ser473
-
Insulin
in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display defective insulin action and a drastic reduction of insulin stimulated activity of all Akt isoforms
-
Insulin
in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt2-Ser473 phosphorylation
-
Insulin
in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt3-Ser473 phosphorylation
-
Insulin
in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt1-Thr308 phosphorylation
-
phosphatidylinositol 3,4,5-trisphosphate
required by PDK1 for phosphorylation and activation of PKB
additional information
activation of serum-regulated and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 and PDK2
-
additional information
activation of SGK by IGF-1 or hydrogen peroxide is initiated by a PtdIns(3,4, 5)P3-dependent activation of PDK2, which phosphorylates Ser422. This is followed by the PtdIns(3,4,5)P3-independent phosphorylation at Thr256 that activates SGK, and is catalysed by PDK1
-
additional information
PKBalpha becomes phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s)
-
additional information
Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage, the response to DNA damage occurrs in an ataxia telangiectasia mutated ATM-dependent manner
-
additional information
-
no activation by calcium/phosphatidylserine/diolein, phosphorylation of PKN is required for full activation
-
additional information
insulin stimulates GSK3 phosphorylation at Ser21 and Ser9 by PKB protein kinase
-
additional information
-
NDR1 is activated by phosphorylation at S281, T444, and T74
-
additional information
expression of the intestinal inflammation-associated colonic epithelial SPAK isozyme is upregulated by the pro-inflammatory cytokine IFN-gamma, but not by TGF-beta and TNF-alpha, overview
-
additional information
-
The pseudokinase sterile-20-related adaptor (STRAD) enhances the cytosolic localization of LKB1 and its catalytic activity by acting as an adaptor between exportins (CRM1 and exportin7) and LKB1
-
additional information
p110alpha-mediated phosphorylation of AMPKa at S485/491 is Akt-dependent
-
additional information
STK38 activity is stimulated by oxidative stresses such as hydrogen peroxide and X-ray irradiation
-
additional information
the enzyme (ATM) is activated in response to DNA double-strand breaks especially caused via gamma irradiation
-
additional information
the enzyme (ATM) is activated in response to DNA double-strand breaks especially caused via gamma irradiation
-
additional information
the enzyme (ATM) is activated in response to DNA double-strand breaks especially caused via gamma irradiation
-
additional information
activation by its dedicated regulator protein DBF4
-
additional information
ATR is activated upon range spectrum of DNA damage agents involving UV light, alkylating agents, chemical inhibitors of DNA replication machinery as well as other pathological conditions that cause DNA single-strand breaks
-
additional information
ATR is activated upon range spectrum of DNA damage agents involving UV light, alkylating agents, chemical inhibitors of DNA replication machinery as well as other pathological conditions that cause DNA single-strand breaks
-
additional information
ATR is activated upon range spectrum of DNA damage agents involving UV light, alkylating agents, chemical inhibitors of DNA replication machinery as well as other pathological conditions that cause DNA single-strand breaks
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
17alpha-hydroxyprogesterone deacetylase deficiency
Early steps in androgen biosynthesis: from cholesterol to DHEA.
Aberrant Crypt Foci
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Aberrant Crypt Foci
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
Aberrant Crypt Foci
Plum polyphenols inhibit colorectal aberrant crypt foci formation in rats: potential role of the miR-143/protein kinase B/mammalian target of rapamycin axis.
Abortion, Habitual
TAAR1 induces a disturbed GSK3? phosphorylation in recurrent miscarriages through the ODC.
Abortion, Spontaneous
Fibroblast Growth Factor 7 Regulates Proliferation and Decidualization of Human Endometrial Stromal Cells via ERK and JNK Pathway in an Autocrine Manner.
Abscess
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Acantholysis
In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades.
Acidosis
Acidosis alters the phosphorylation of Ser16 and Thr17 of phospholamban in rat cardiac muscle.
Acidosis
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Acidosis
Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
Acidosis
Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis.
Acidosis
CaMKII? Met281/282 oxidation is not required for recovery of calcium transients during acidosis.
Acidosis
Compensatory role of CaMKII on ICa and SR function during acidosis in rat ventricular myocytes.
Acidosis
Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway.
Acidosis
GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices.
Acidosis
Hypercapnia Accelerates Adipogenesis: A Novel Role of High CO2 in Exacerbating Obesity.
Acidosis
Hypercapnic acidosis confers antioxidant and anti-apoptosis effects against ventilator-induced lung injury.
Acidosis
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Acidosis
Intracellular acidosis via activation of Akt-Girdin signaling promotes post ischemic angiogenesis during hyperglycemia.
Acidosis
Mechanisms involved in the acidosis enhancement of the isoproterenol-induced phosphorylation of phospholamban in the intact heart.
Acidosis
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.
Acidosis
Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes.
Acidosis
Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes.
Acidosis
Role of CaMKII in post acidosis arrhythmias: a simulation study using a human myocyte model.
Acidosis, Lactic
Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like episodes.
Acidosis, Lactic
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Acquired Immunodeficiency Syndrome
Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Acquired Immunodeficiency Syndrome
Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis.
Acquired Immunodeficiency Syndrome
Diagnosis of Creutzfeldt-Jakob disease: effect of clinical criteria on incidence estimates. Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Acquired Immunodeficiency Syndrome
Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis.
Acquired Immunodeficiency Syndrome
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.
Acquired Immunodeficiency Syndrome
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
Acquired Immunodeficiency Syndrome
Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination.
Acquired Immunodeficiency Syndrome
Neuroprotective strategies for HIV-1 associated dementia.
Acquired Immunodeficiency Syndrome
Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices.
Acquired Immunodeficiency Syndrome
The fine-structural distribution of G-protein receptor kinase 3, beta-arrestin-2, Ca2+/calmodulin-dependent protein kinase II and phosphodiesterase PDE1C2, and a Cl(-)-cotransporter in rodent olfactory epithelia.
Acquired Immunodeficiency Syndrome
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Acute Kidney Injury
Activity of the Ste20-like Kinase, SLK, is Enhanced by Homodimerization.
Acute Kidney Injury
Effect of ATM on inflammatory response and autophagy in renal tubular epithelial cells in LPS-induced septic AKI.
Acute Kidney Injury
Effects of chronic alcohol exposure on ischemia-reperfusion-induced acute kidney injury in mice: the role of ?-arrestin 2 and glycogen synthase kinase 3.
Acute Kidney Injury
Glutamine attenuates tubular cell apoptosis in acute kidney injury via inhibition of the c-Jun N-terminal kinase phosphorylation of 14-3-3*
Acute Kidney Injury
Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice.
Acute Kidney Injury
Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.
Acute Kidney Injury
Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis.
Acute Kidney Injury
Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Acute Kidney Injury
Meprin ? Activity Modulates the beta Catalytic Subunit of Protein Kinase A (PKA C?) in Ischemia/Reperfusion-Induced Acute Kidney Injury.
Acute Kidney Injury
Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.
Acute Kidney Injury
Regulation of the Ste20-like Kinase, SLK: INVOLVEMENT OF ACTIVATION SEGMENT PHOSPHORYLATION.
Acute Kidney Injury
ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress/pyroptosis axis.
Acute Lung Injury
Acid-Induced Acute Lung Injury in Mice Associates with p44/42 and c-Jun N-Terminal Kinase Activation and Requires the Function of Tumor Necrosis Factor-? Receptor I.
Acute Lung Injury
Activation of protein kinase A is required for hydroxysafflor yellow A-mediated protection against oleic acid-induced acute lung injury.
Acute Lung Injury
Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-?B signaling pathway.
Acute Lung Injury
Deletion of peroxiredoxin 6 is protective in lipopolysaccharide-induced acute lung injury in mice*
Acute Lung Injury
Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis.
Acute Lung Injury
GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury.
Acute Lung Injury
MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1.
Acute Lung Injury
Protective role of JNK inhibitor SP600125 in sepsis-induced acute lung injury.
Acute Lung Injury
ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress/pyroptosis axis.
Acute Lung Injury
Tanshinone IIA suppresses lung injury and apoptosis, and modulates protein kinase B and extracellular signal-regulated protein kinase pathways in rats challenged with seawater exposure.
Acute Radiation Syndrome
Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain- Dependent Manner in Mice.
Acute Radiation Syndrome
Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in Mice.
Adenocarcinoma
(-)-Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC?1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Adenocarcinoma
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Adenocarcinoma
A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome.
Adenocarcinoma
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
Adenocarcinoma
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
Adenocarcinoma
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Adenocarcinoma
Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia.
Adenocarcinoma
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice.
Adenocarcinoma
Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development.
Adenocarcinoma
Autophagy Regulatory Genes MET and RIPK2 Play a Prognostic Role in Pancreatic Ductal Adenocarcinoma: A Bioinformatic Analysis Based on GEO and TCGA.
Adenocarcinoma
BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation.
Adenocarcinoma
Citron Rho-Interacting Serine/Threonine Kinase Promotes HIF1a-CypA Signaling and Growth of Human Pancreatic Adenocarcinoma.
Adenocarcinoma
Clinicopathological and Molecular Study of Peritoneal Carcinomatosis Associated with Non-Small Cell Lung Carcinoma.
Adenocarcinoma
Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA).
Adenocarcinoma
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Adenocarcinoma
Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9.
Adenocarcinoma
Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis.
Adenocarcinoma
Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer.
Adenocarcinoma
Correlation among RKIP expression, NF-?B p65 levels, and T-lymphocyte subsets in gastric cardia adenocarcinoma.
Adenocarcinoma
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Adenocarcinoma
Curcumin Rescues Doxorubicin Responsiveness via Regulating Aurora a Signaling Network in Breast Cancer Cells.
Adenocarcinoma
Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4.
Adenocarcinoma
Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models.
Adenocarcinoma
DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.
Adenocarcinoma
Edible oil adulterants, argemone oil and butter yellow, as aetiological factors for gall bladder cancer.
Adenocarcinoma
Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.
Adenocarcinoma
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Adenocarcinoma
Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy.
Adenocarcinoma
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Adenocarcinoma
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Adenocarcinoma
Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma.
Adenocarcinoma
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
Adenocarcinoma
Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo.
Adenocarcinoma
Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis.
Adenocarcinoma
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Adenocarcinoma
Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing.
Adenocarcinoma
Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome.
Adenocarcinoma
Glycogen Synthase Kinase 3 Beta Predicts Survival in Resected Adenocarcinoma of the Pancreas.
Adenocarcinoma
GSK-3 inhibitors enhance TRAIL-mediated apoptosis in human gastric adenocarcinoma cells.
Adenocarcinoma
High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.
Adenocarcinoma
Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants.
Adenocarcinoma
HT 29, a model cell line: stimulation by the vasoactive intestinal peptide (VIP); VIP receptor structure and metabolism.
Adenocarcinoma
Immunohistochemical analysis of Ki-67, PCNA and S6K1/2 expression in human breast cancer.
Adenocarcinoma
Immunohistochemical analysis of S6K1 and S6K2 expression in endometrial adenocarcinomas.
Adenocarcinoma
Immunohistochemical characterization of the mTOR pathway in stage-I non-small-cell lung carcinoma.
Adenocarcinoma
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
Adenocarcinoma
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Adenocarcinoma
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells.
Adenocarcinoma
Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells.
Adenocarcinoma
Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.
Adenocarcinoma
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression.
Adenocarcinoma
Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome.
Adenocarcinoma
Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A.
Adenocarcinoma
LncRNA LINK-A regulates ROCK1 expression in early-stage pancreatic adenocarcinoma.
Adenocarcinoma
lncRNA-CCHE1 is involved in migration and invasion but not in proliferation of pancreatic adenocarcinoma cells possibly by interacting with ROCK1.
Adenocarcinoma
Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC).
Adenocarcinoma
Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Low expression of A-kinase anchor protein 5 predicts poor prognosis in non-mucin producing stomach adenocarcinoma based on TCGA data.
Adenocarcinoma
Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit.
Adenocarcinoma
Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations.
Adenocarcinoma
Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase ?1 expression.
Adenocarcinoma
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.
Adenocarcinoma
Modified protein kinase activity and isozyme distribution in adenocarcinoma of the human colon.
Adenocarcinoma
Molecular and pathological basis of HPV-negative cervical adenocarcinoma seen in a global study.
Adenocarcinoma
Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement.
Adenocarcinoma
Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.
Adenocarcinoma
Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11.
Adenocarcinoma
Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas.
Adenocarcinoma
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Adenocarcinoma
Na+/H+ exchanger regulatory factor 1 overexpression suppresses the malignant phenotype of MIAPaCa-2 pancreatic adenocarcinoma cells by downregulating Akt phosphorylation.
Adenocarcinoma
NEAT1/miR-101-dependent Up-regulation of DNA-PKcs Enhances Malignant Behaviors of Pancreatic Ductal Adenocarcinoma Cells.
Adenocarcinoma
Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers.
Adenocarcinoma
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.
Adenocarcinoma
Next-Generation Sequencing Approach to Non-Small Cell Lung Carcinoma Yields More Actionable Alterations.
Adenocarcinoma
Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma.
Adenocarcinoma
Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma.
Adenocarcinoma
PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.
Adenocarcinoma
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.
Adenocarcinoma
Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer.
Adenocarcinoma
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer.
Adenocarcinoma
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Adenocarcinoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Adenocarcinoma
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Adenocarcinoma
Promoter methylation of Raf kinase inhibitory protein: A significant prognostic indicator for patients with gastric adenocarcinoma.
Adenocarcinoma
Protein kinase B phosphorylation correlates with vascular endothelial growth factor a and microvessel density in gastric adenocarcinoma.
Adenocarcinoma
Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
Adenocarcinoma
REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer.
Adenocarcinoma
Reduced level of the spindle checkpoint protein BUB1B is associated with aneuploidy in colorectal cancers.
Adenocarcinoma
Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
Adenocarcinoma
ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.
Adenocarcinoma
Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer.
Adenocarcinoma
Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours.
Adenocarcinoma
STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1?.
Adenocarcinoma
Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
Adenocarcinoma
Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library.
Adenocarcinoma
The effect of menadione on glutathione S-transferase A1 (GSTA1): c-Jun N-terminal kinase (JNK) complex dissociation in human colonic adenocarcinoma Caco-2 cells.
Adenocarcinoma
The PRKD1 promoter is a target of the KRas-NF-?B pathway in pancreatic cancer.
Adenocarcinoma
The usefulness of S100P, mesothelin, fascin, prostate stem cell antigen, and 14-3-3 sigma in diagnosing pancreatic adenocarcinoma in cytological specimens obtained by endoscopic ultrasound guided fine-needle aspiration.
Adenocarcinoma
Tumor-promoting phorbol ester down-regulates the androgen induction of prostate-specific antigen in a human prostatic adenocarcinoma cell line.
Adenocarcinoma
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.
Adenocarcinoma
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Adenocarcinoma
[Determination of cyclic AMP and protein kinases in the diagnosis of colonic tumors]
Adenocarcinoma
[Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]
Adenocarcinoma of Lung
37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade.
Adenocarcinoma of Lung
A combination of tumor and molecular markers predicts a poor prognosis in lung adenocarcinoma.
Adenocarcinoma of Lung
A phase II study of everolimus in patients with advanced solid malignancies with TSC1, TSC2, NF1, NF2 or STK11 mutations.
Adenocarcinoma of Lung
A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Aberrant Stratifin Overexpression Is Regulated by Tumor-Associated CpG Demethylation in Lung Adenocarcinoma.
Adenocarcinoma of Lung
AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
Adenocarcinoma of Lung
Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells.
Adenocarcinoma of Lung
Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling.
Adenocarcinoma of Lung
Association of serine/threonine kinase 11 mutations and response to programmed cell death 1 inhibitors in metastatic gastric cancer.
Adenocarcinoma of Lung
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Adenocarcinoma of Lung
Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome.
Adenocarcinoma of Lung
Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway.
Adenocarcinoma of Lung
Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.
Adenocarcinoma of Lung
Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9.
Adenocarcinoma of Lung
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.
Adenocarcinoma of Lung
Correction: STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort.
Adenocarcinoma of Lung
Correlation between STK33 and the pathology and prognosis of lung cancer.
Adenocarcinoma of Lung
Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ß-catenin pathway.
Adenocarcinoma of Lung
Cyclic AMP-responsive expression of the surfactant protein-A gene is mediated by increased DNA binding and transcriptional activity of thyroid transcription factor-1.
Adenocarcinoma of Lung
Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma.
Adenocarcinoma of Lung
Distinct biological effects of low-dose radiation on normal and cancerous human lung cells are mediated by ATM signaling.
Adenocarcinoma of Lung
DNA-dependent protein kinase catalytic subunit inhibitor reverses acquired radioresistance in lung adenocarcinoma by suppressing DNA repair.
Adenocarcinoma of Lung
Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis.
Adenocarcinoma of Lung
Effect of 14-3-3 protein induction on cell proliferation of A549 human lung adenocarcinoma.
Adenocarcinoma of Lung
Estrogen related receptor-alpha enhances surfactant protein-A gene expression in fetal lung type II cells.
Adenocarcinoma of Lung
Expression and clinical significance of A-kinase anchor protein 4 in lung adenocarcinoma tissue.
Adenocarcinoma of Lung
Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma.
Adenocarcinoma of Lung
Expression of AKT and p-AKT protein in lung adenocarcinoma and its correlation with PD-L1 protein and prognosis.
Adenocarcinoma of Lung
Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients.
Adenocarcinoma of Lung
Glycogen synthase kinase 3beta induces cell cycle arrest in a cyclin D1-dependent manner in human lung adenocarcinoma cell line A549.
Adenocarcinoma of Lung
Identification of unique heterozygous germline mutation, STK11 (p.F354L), in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for neuroblastoma.
Adenocarcinoma of Lung
Incidence of Lung Adenocarcinoma Biomarker in a Caribbean and African Caribbean Population.
Adenocarcinoma of Lung
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Adenocarcinoma of Lung
Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3? and osteopontin.
Adenocarcinoma of Lung
Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells.
Adenocarcinoma of Lung
Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.
Adenocarcinoma of Lung
Less immune cell infiltration and worse prognosis after immunotherapy for patients with lung adenocarcinoma who harbored STK11 mutation.
Adenocarcinoma of Lung
LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.
Adenocarcinoma of Lung
LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence.
Adenocarcinoma of Lung
LncRNA MALAT1 regulates trophoblast cells migration and invasion via miR-206/IGF-1 axis.
Adenocarcinoma of Lung
Loss of cellular identity in common pre-clinical models of serine?threonine kinase 11 (Liver kinase B1) loss.
Adenocarcinoma of Lung
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Adenocarcinoma of Lung
MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.
Adenocarcinoma of Lung
MicroRNA-197 induces epithelial-mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinoma.
Adenocarcinoma of Lung
MiR-195-5p is a Potential Factor Responsible for CPNE1 Differential Expression between Subtypes of Non-Small Cell Lung Cancer.
Adenocarcinoma of Lung
Molecular alterations in non-small cell lung carcinomas of the young.
Adenocarcinoma of Lung
mRNA expression of programmed cell death ligand 1 and components of the phosphatidylinositol 3-kinase/AKT/phosphatase and tensin homolog pathway in epidermal growth factor receptor mutation-positive lung adenocarcinoma.
Adenocarcinoma of Lung
Multiparameter analysis using cell cycle biomarkers for small-size lung adenocarcinoma: prognostic implications.
Adenocarcinoma of Lung
Multiplex Diagnosis of Oncogenic Fusion and MET Exon Skipping by Molecular Counting Using Formalin-Fixed Paraffin Embedded Lung Adenocarcinoma Tissues.
Adenocarcinoma of Lung
Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma.
Adenocarcinoma of Lung
MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Adenocarcinoma of Lung
NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes.
Adenocarcinoma of Lung
Overexpressed Raf-1 and phosphorylated cyclic adenosine 3'-5'-monophosphatate response element-binding protein are early markers for lung adenocarcinoma.
Adenocarcinoma of Lung
Overexpression of HOTTIP promotes proliferation and drug resistance of lung adenocarcinoma by regulating AKT signaling pathway.
Adenocarcinoma of Lung
Overexpression of T-LAK cell-originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma.
Adenocarcinoma of Lung
PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma.
Adenocarcinoma of Lung
Relevance of STK11 Mutations Regarding Immune Cell Infiltration, Drug Sensitivity, and Cellular Processes in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4.
Adenocarcinoma of Lung
RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation.
Adenocarcinoma of Lung
Serum proteomics of lung adenocarcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers.
Adenocarcinoma of Lung
SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.
Adenocarcinoma of Lung
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Adenocarcinoma of Lung
Somatic STK11 and Concomitant STK11/KRAS Mutational Frequency in Stage IV Lung Adenocarcinoma Adrenal Metastases.
Adenocarcinoma of Lung
STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort.
Adenocarcinoma of Lung
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.
Adenocarcinoma of Lung
STK33-dependent transcriptional regulation of SFTA3 induces Cisplatin-resistance in lung adenocarcinoma.
Adenocarcinoma of Lung
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.
Adenocarcinoma of Lung
The effect of ataxia-telangiectasia mutated kinase-dependent hyperphosphorylation of checkpoint kinase-2 on oligodeoxynucleotide 7909 containing CpG motifs-enhanced sensitivity to X-rays in human lung adenocarcinoma A549 cells.
Adenocarcinoma of Lung
The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.
Adenocarcinoma of Lung
TP53, STK11, and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Undetectable circulating tumor DNA levels correlate with low risk of recurrence/metastasis in postoperative pathologic stage I lung adenocarcinoma patients.
Adenocarcinoma of Lung
[Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radiosensitivity]
Adenocarcinoma of Lung
[Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]
Adenocarcinoma of Lung
[The effects of Tumstatin185-191 on lung adenocarcinoma cell lines and the association with protein kinase B and extracellularregulated protein kinase activation.]
Adenocarcinoma, Bronchiolo-Alveolar
Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome.
Adenocarcinoma, Clear Cell
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Adenocarcinoma, Follicular
ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status.
Adenocarcinoma, Follicular
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Adenocarcinoma, Follicular
PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.
Adenocarcinoma, Mucinous
A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region.
Adenocarcinoma, Mucinous
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Adenocarcinoma, Mucinous
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Adenocarcinoma, Mucinous
Peutz-Jeghers syndrome complicated by gastric-type cervical mucinous carcinoma and primary peritoneal carcinoma.
Adenocarcinoma, Mucinous
Pulmonary Invasive Mucinous Adenocarcinoma and Mixed Invasive Mucinous/Non-Mucinous Adenocarcinoma- A Clinicopathological and Molecular Genetic Study with Survival Analysis.
Adenocarcinoma, Mucinous
[Correlations between the p-Akt-mTOR-p70S6K pathway and clinicopathological features or chemoresistance of ovarian cancer].
Adenoma
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Adenoma
18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway.
Adenoma
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation.
Adenoma
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
Adenoma
Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia.
Adenoma
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Adenoma
Calmodulin and calmodulin-dependent protein kinase II (CaMKII) inhibit hormone secretion in human parathyroid adenoma.
Adenoma
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
Adenoma
Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.
Adenoma
DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.
Adenoma
Down-regulation of D2 dopamine receptor and increased protein kinase Cmu phosphorylation in aldosterone-producing adenoma play roles in aldosterone overproduction.
Adenoma
Edible oil adulterants, argemone oil and butter yellow, as aetiological factors for gall bladder cancer.
Adenoma
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Adenoma
Increased protein kinase A type I? regulatory subunit expression in parathyroid gland adenomas of patients with primary hyperparathyroidism.
Adenoma
Lipopolysaccharides Enhance Epithelial Hyperplasia and Tubular Adenoma in Intestine-Specific Expression of krasV12 in Transgenic Zebrafish.
Adenoma
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Adenoma
Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
Adenoma
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Adenoma
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Adenoma
Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma.
Adenoma
PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
Adenoma
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Adenoma
Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library.
Adenoma
The gsp Oncogene Disrupts Ras/ERK-Dependent Prolactin Gene Regulation in gsp Inducible Somatotroph Cell Line.
Adenoma
[Clinicopathological significance of expression and amplification of P21-activated kinase 1 gene in colorectal carcinoma]
Adenoma
[Construction of GSK-3beta-targeting RNAi adenovirus vector and the influence of Wnt/beta-catenin pathway in proliferation of human thyrocytes]
Adenoma
[Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma].
Adenoma
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Adenoma, Bile Duct
Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats.
Adenoma, Liver Cell
Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma.
Adenoma, Oxyphilic
Akt signalling parameters are different in oncocytomas compared to renal cell carcinoma.
Adenoma, Pleomorphic
Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma.
Adenomatous Polyposis Coli
?-catenin at the centrosome: Discrete pools of ?-catenin communicate during mitosis and may co-ordinate centrosome functions and cell cycle progression.
Adenomatous Polyposis Coli
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.
Adenomatous Polyposis Coli
Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.
Adenomatous Polyposis Coli
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.
Adenomatous Polyposis Coli
Adenomatous polyposis coli (APC)-independent regulation of beta-catenin degradation via a retinoid X receptor-mediated pathway.
Adenomatous Polyposis Coli
Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo.
Adenomatous Polyposis Coli
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
Adenomatous Polyposis Coli
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.
Adenomatous Polyposis Coli
Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.
Adenomatous Polyposis Coli
Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway.
Adenomatous Polyposis Coli
Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling.
Adenomatous Polyposis Coli
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.
Adenomatous Polyposis Coli
Beta-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts.
Adenomatous Polyposis Coli
Beta-catenin is temporally regulated during normal liver development.
Adenomatous Polyposis Coli
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
Adenomatous Polyposis Coli
Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription.
Adenomatous Polyposis Coli
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK.
Adenomatous Polyposis Coli
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity.
Adenomatous Polyposis Coli
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.
Adenomatous Polyposis Coli
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.
Adenomatous Polyposis Coli
Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.
Adenomatous Polyposis Coli
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
Adenomatous Polyposis Coli
Control of beta-catenin/Tcf-directed transcription in medulloblastoma.
Adenomatous Polyposis Coli
Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway.
Adenomatous Polyposis Coli
Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin.
Adenomatous Polyposis Coli
Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons.
Adenomatous Polyposis Coli
DNA hypermethylation profiles in squamous cell carcinoma of the vulva.
Adenomatous Polyposis Coli
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.
Adenomatous Polyposis Coli
Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice.
Adenomatous Polyposis Coli
Effects of rat Axin domains on axis formation in Xenopus embryos.
Adenomatous Polyposis Coli
Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells.
Adenomatous Polyposis Coli
Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.
Adenomatous Polyposis Coli
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Adenomatous Polyposis Coli
Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.
Adenomatous Polyposis Coli
Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin.
Adenomatous Polyposis Coli
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.
Adenomatous Polyposis Coli
H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes.
Adenomatous Polyposis Coli
Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway.
Adenomatous Polyposis Coli
Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
Adenomatous Polyposis Coli
Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.
Adenomatous Polyposis Coli
Identification of a Wnt/beta-catenin signaling pathway in human thyroid cells.
Adenomatous Polyposis Coli
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Adenomatous Polyposis Coli
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
Adenomatous Polyposis Coli
IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways.
Adenomatous Polyposis Coli
Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A.
Adenomatous Polyposis Coli
Inhibition of Wnt signaling pathway by a novel axin-binding protein.
Adenomatous Polyposis Coli
Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction.
Adenomatous Polyposis Coli
Intracholecystic Papillary Neoplasms Are Distinct From Papillary Gallbladder Cancers: A Clinicopathologic and Exome-sequencing Study.
Adenomatous Polyposis Coli
Involvement of CDX2 in the cross talk between TNF-? and Wnt signaling pathway in the colon cancer cell line Caco-2.
Adenomatous Polyposis Coli
Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.
Adenomatous Polyposis Coli
LKB1-mediated spatial control of GSK3beta and adenomatous polyposis coli contributes to centrosomal forward movement and neuronal migration in the developing neocortex.
Adenomatous Polyposis Coli
Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system.
Adenomatous Polyposis Coli
Long non-coding RNA miR143HG predicts good prognosis and inhibits tumor multiplication and metastasis by suppressing mitogen-activated protein kinase and Wnt signaling pathways in hepatocellular carcinoma.
Adenomatous Polyposis Coli
Long-fragment DNA as a potential marker for stool-based detection of colorectal cancer.
Adenomatous Polyposis Coli
LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
Adenomatous Polyposis Coli
Manilkara zapota (L.) P. Royen leaf water extract triggered apoptosis and activated caspase-dependent pathway in HT-29 human colorectal cancer cell line.
Adenomatous Polyposis Coli
MicroRNA-218 competes with differentiation media in the induction of osteogenic differentiation of mesenchymal stem cell by regulating ?-catenin inhibitors.
Adenomatous Polyposis Coli
Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells.
Adenomatous Polyposis Coli
Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.
Adenomatous Polyposis Coli
Molecular regulation and pharmacological targeting of the ?-catenin destruction complex.
Adenomatous Polyposis Coli
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.
Adenomatous Polyposis Coli
Nestin positively regulates the Wnt/?-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells.
Adenomatous Polyposis Coli
Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3{beta}) independently of Akt/PKB serine phosphorylation.
Adenomatous Polyposis Coli
Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation.
Adenomatous Polyposis Coli
Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
Adenomatous Polyposis Coli
Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.
Adenomatous Polyposis Coli
Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion.
Adenomatous Polyposis Coli
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis.
Adenomatous Polyposis Coli
Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway.
Adenomatous Polyposis Coli
Phase separation of Axin organizes the ?-catenin destruction complex.
Adenomatous Polyposis Coli
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
Adenomatous Polyposis Coli
Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axin.
Adenomatous Polyposis Coli
Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization.
Adenomatous Polyposis Coli
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
Adenomatous Polyposis Coli
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
Adenomatous Polyposis Coli
Targeted degradation of beta-catenin by chimeric F-box fusion proteins.
Adenomatous Polyposis Coli
The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli.
Adenomatous Polyposis Coli
The control of beta-catenin and TCF during embryonic development and cancer.
Adenomatous Polyposis Coli
The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats.
Adenomatous Polyposis Coli
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
Adenomatous Polyposis Coli
The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling.
Adenomatous Polyposis Coli
Thr160 of Axin1 is critical for the formation and function of the ?-catenin destruction complex.
Adenomatous Polyposis Coli
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.
Adenomatous Polyposis Coli
Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.
Adenomatous Polyposis Coli
Vital elements of the Wnt-Frizzled signaling pathway in the nervous system.
Adenomatous Polyposis Coli
Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/?-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced colon carcinogenesis.
Adenomatous Polyposis Coli
Wnt-independent beta-catenin transactivation in tumor development.
Adenomatous Polyposis Coli
Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta.
Adenomatous Polyposis Coli
[Dynamic changes of adenomatous polyposis coli protein and glycogen synthase kinase 3beta in the repair of the injured airway epithelial cells in smoking mice.]
Adenomatous Polyposis Coli
[Spatial-temporal distribution of glycogen synthase kinase 3beta and adenomatous polyposis coli protein are involved in the injury and repair of airway epithelial cells induced by scratching.]
Adenomatous Polyps
Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
Adenomatous Polyps
[Determination of cyclic AMP and protein kinases in the diagnosis of colonic tumors]
Adenomatous Polyps
[Peutz-Jeghers Syndrome with Adenomatous Change in a Fifteen-month-old Boy].
Adenomyoepithelioma
Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.
Adenomyosis
Increased expression of p21-activated kinase 4 in adenomyosis and its regulation of matrix metalloproteinase-2 and -9 in endometrial cells.
Adenomyosis
Linc-ROR promotes endometrial cell proliferation by activating the PI3K-Akt pathway.
Adenomyosis
RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
Adenomyosis
[The expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in adenomyosis].
Adenoviridae Infections
Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription.
Adenoviridae Infections
Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression.
Adenoviridae Infections
Adenovirus infection targets the cellular protein kinase CK2 and RNA-activated protein kinase (PKR) into viral inclusions of the cell nucleus.
Adenoviridae Infections
Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin.
Adrenal Cortex Neoplasms
Bitter Melon (Momordica charantia) Extract Suppresses Adrenocortical Cancer Cell Proliferation Through Modulation of the Apoptotic Pathway, Steroidogenesis, and Insulin-Like Growth Factor Type 1 Receptor/RAC-? Serine/Threonine-Protein Kinase Signaling.
Adrenocortical Adenoma
ACTH-induced cortisol secretion is mediated by cAMP and PKC in various adrenocortical adenomas.
Adrenocortical Adenoma
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Adrenocortical Adenoma
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Adrenocortical Adenoma
Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.
Adrenocortical Adenoma
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
Adrenocortical Adenoma
PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.
Adrenocortical Adenoma
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Adrenocortical Adenoma
Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma.
Adrenocortical Carcinoma
Advances in understanding the molecular underpinnings of adrenocortical tumors.
Adrenocortical Carcinoma
Angiotensin II-activated protein kinase D mediates acute aldosterone secretion.
Adrenocortical Carcinoma
Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro.
Adrenocortical Carcinoma
Ataxia telangiectasia mutated germline pathogenic variant in adrenocortical carcinoma.
Adrenocortical Carcinoma
Characterization of a cyclic nucleotide-independent protein kinase highly active in human adrenocortical carcinoma.
Adrenocortical Carcinoma
Cyclic AMP regulates expression of the gene coding for a mouse vas deferens protein related to the aldo-keto reductase superfamily in human and murine adrenocortical cells.
Adrenocortical Carcinoma
Expression and regulation of the lipoprotein lipase gene in human adrenal cortex.
Adrenocortical Carcinoma
Expression of autophosphorylating protein kinase 500 in normal and neoplastic rat cells.
Adrenocortical Carcinoma
Regulation of the scavenger receptor BI and the LDL receptor by activators of aldosterone production, angiotensin II and PMA, in the human NCI-H295R adrenocortical cell line.
Adrenoleukodystrophy
Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP.
African Swine Fever
African swine fever virus encodes a serine protein kinase which is packaged into virions.
Agammaglobulinemia
WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice.
Aggressive Periodontitis
Calcium-dependent protein kinase C activity of neutrophils in localized juvenile periodontitis.
AIDS Dementia Complex
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
AIDS-Associated Nephropathy
A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-?1/Smad3 Pathway.
Albuminuria
Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease.
Albuminuria
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Albuminuria
Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor.
Albuminuria
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes.
Albuminuria
Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat.
Albuminuria
Podocyte Injury and Albuminuria in Mice with Podocyte-Specific Overexpression of the Ste20-Like Kinase, SLK.
Albuminuria
ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy.
Alopecia
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Alveolar Bone Loss
Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss.
Alzheimer Disease
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.
Alzheimer Disease
1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation.
Alzheimer Disease
14-3-3 protein beta isoform is associated with 3-repeat tau neurofibrillary tangles in Alzheimer's disease.
Alzheimer Disease
14-3-3 proteins and zeta isoform containing neurofibrillary tangles in patients with Alzheimer's disease.
Alzheimer Disease
14-3-3 Zeta and Tau Genes Interactively Decrease Alzheimer's Disease Risk.
Alzheimer Disease
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.
Alzheimer Disease
2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3beta with Good Brain Permeability.
Alzheimer Disease
3D-QSAR and Molecular Docking Studies on 3-Anilino-4-Arylmaleimide Derivatives as Glycogen Synthase Kinase-3? Inhibitors.
Alzheimer Disease
3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors.
Alzheimer Disease
?-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3.
Alzheimer Disease
?2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer's disease models.
Alzheimer Disease
A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.
Alzheimer Disease
A combination extract of Renshen (Panax Ginseng), Yinyanghuo (Herba Epimedii Brevicornus), Yuanzhi (Radix Palygalae) and Jianghuang (Rhizoma Curcumae Longae) decreases glycogen synthase kinase 3beta expression in brain cortex of APPV7171 transgenic mice.
Alzheimer Disease
A high throughput and sensitive method correlates neuronal disorder genotypes to Drosophila larvae crawling phenotypes.
Alzheimer Disease
A longitudinal FDG-PET study of transgenic mice overexpressing GSK-3? in the brain.
Alzheimer Disease
A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
Alzheimer Disease
A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S?)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.
Alzheimer Disease
A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.
Alzheimer Disease
A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Alzheimer Disease
Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.
Alzheimer Disease
Activation of glycogen synthase kinase-3 beta mediates ?-amyloid induced neuritic damage in Alzheimer's disease.
Alzheimer Disease
Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture.
Alzheimer Disease
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
Alzheimer Disease
Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease.
Alzheimer Disease
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.
Alzheimer Disease
Age-related changes in glycogen synthase kinase 3beta (GSK3beta) immunoreactivity in the central nervous system of rats.
Alzheimer Disease
Akt activity in Alzheimer's disease and other neurodegenerative disorders.
Alzheimer Disease
Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations.
Alzheimer Disease
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.
Alzheimer Disease
Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer's Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation.
Alzheimer Disease
Alternative splicing of the porcine glycogen synthase kinase 3? (GSK-3?) gene with differential expression patterns and regulatory functions.
Alzheimer Disease
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.
Alzheimer Disease
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.
Alzheimer Disease
Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.
Alzheimer Disease
American Chemical Society - 240th national meeting - chemistry for preventing and combating disease: part 2.
Alzheimer Disease
AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on ?-amyloid clearance.
Alzheimer Disease
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
Alzheimer Disease
Amyloid Beta 1-42 Inhibits Entorhinal Cortex Gamma Bursts: Role of GSK-3.
Alzheimer Disease
An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
Alzheimer Disease
Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan.
Alzheimer Disease
Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain.
Alzheimer Disease
Antibodies against beta-amyloid reduce abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.
Alzheimer Disease
Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta.
Alzheimer Disease
Application of an ESI-QTOF method for the detailed characterization of GSK-3? inhibitors.
Alzheimer Disease
Application of graph theory: prediction of glycogen synthase kinase-3 beta inhibitory activity of thiadiazolidinones as potential drugs for the treatment of Alzheimer's disease.
Alzheimer Disease
Association between Glycogen Synthase Kinase-3beta Genetic Polymorphism and Late-Onset Alzheimer's Disease.
Alzheimer Disease
Author Correction: Inhibition of casein kinase 1?/?improves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease.
Alzheimer Disease
A meta-analysis of leucine-rich repeat kinase 2 (LRRK2) polymorphisms in Alzheimer's disease.
Alzheimer Disease
Biochemical characterization of tau protein and its associated syndapin 1 and protein kinase Cepsilon for their functional regulation in rat brain.
Alzheimer Disease
Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases.
Alzheimer Disease
c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease.
Alzheimer Disease
c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo.
Alzheimer Disease
c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer's Diseases.
Alzheimer Disease
C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Alzheimer Disease
cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer disease.
Alzheimer Disease
Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease.
Alzheimer Disease
Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis.
Alzheimer Disease
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Alzheimer Disease
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Alzheimer Disease
Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain.
Alzheimer Disease
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Alzheimer Disease
Casein kinase II alteration precedes tau accumulation in tangle formation.
Alzheimer Disease
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Alzheimer Disease
Characterization of Parkinson's disease-related pathogenic TMEM230 mutants.
Alzheimer Disease
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.
Alzheimer Disease
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.
Alzheimer Disease
CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment.
Alzheimer Disease
Clinical Chemistry Route for Investigation of Alzheimer's Disease: A Label-Free Electrochemiluminescent Biosensor for Glycogen Synthase Kinase-3 Beta.
Alzheimer Disease
Co-occurrence of sporadic parkinsonism and late-onset Alzheimer's disease in a Brazilian male with the LRRK2 p.G2019S mutation.
Alzheimer Disease
Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1.
Alzheimer Disease
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3.
Alzheimer Disease
Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease.
Alzheimer Disease
CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD.
Alzheimer Disease
D-serine Ameliorates Motor and Cognitive Impairments in ?-amyloid 1-42 Injected Mice by Inhibiting JNK Signaling Pathway.
Alzheimer Disease
Death-Associated Protein Kinase 1 As A Promising Drug Target In Cancer and Alzheimer's Disease.
Alzheimer Disease
Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.
Alzheimer Disease
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Alzheimer Disease
Decreased cyclin dependent kinase in brain of patients with Down syndrome.
Alzheimer Disease
Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.
Alzheimer Disease
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice.
Alzheimer Disease
Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin.
Alzheimer Disease
Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.
Alzheimer Disease
Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.
Alzheimer Disease
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Alzheimer Disease
Design, Bio-evaluation and Molecular Dynamics Simulation of Novel GSK-3? Inhibitors.
Alzheimer Disease
Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
Alzheimer Disease
Designing of dual inhibitors for GSK-3? and CDK5: Virtual screening and in vitro biological activities study.
Alzheimer Disease
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Alzheimer Disease
Determination of kinetic parameters and structure-activity relationships of ginsenosides as inhibitors of cyclin-dependent kinase 5/p25 using ultra-pressure liquid chromatography with triple quadrupole tandem mass spectrometry.
Alzheimer Disease
Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer's disease: a multicenter pilot study.
Alzheimer Disease
Development of a Cellular Tau Enzyme-Linked Immunosorbent Assay Method for Screening GSK-3? Inhibitors.
Alzheimer Disease
Diagnosis associated with Tau higher than 1200?pg/mL: Insights from the clinical and laboratory practice.
Alzheimer Disease
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
Alzheimer Disease
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Alzheimer Disease
Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus.
Alzheimer Disease
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.
Alzheimer Disease
Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
Alzheimer Disease
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.
Alzheimer Disease
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Alzheimer Disease
Does oxidatively damaged DNA drive amyloid-? generation in Alzheimer's disease? A hypothesis.
Alzheimer Disease
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain.
Alzheimer Disease
Dynamic range of GSK3? not GSK3? is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses.
Alzheimer Disease
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.
Alzheimer Disease
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Alzheimer Disease
Effect of glycogen synthase kinase 3 ?-mediated presenilin 1 phosphorylation on amyloid ? production is negatively regulated by insulin receptor cleavage.
Alzheimer Disease
Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.
Alzheimer Disease
Effect of truncated-ApoE4 overexpression on tau phosphorylation in cultured N2a cells.
Alzheimer Disease
Effects of a Glycogen Synthase Kinase 3 Inhibitor Tideglusib on Bone Regeneration With Calvarial Defects.
Alzheimer Disease
Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice.
Alzheimer Disease
Efficacy and Safety of Glycogen Synthase Kinase 3 Inhibitors for Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Alzheimer Disease
Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair.
Alzheimer Disease
Elevation of casein kinase 1? associated with TDP-43 and tau pathologies in Alzheimer's disease.
Alzheimer Disease
Enantioselective synthesis of the novel chiral sulfoxide derivative as a glycogen synthase kinase 3beta inhibitor.
Alzheimer Disease
Enhanced expression of 14-3-3 proteins in reactive astrocytes in Creutzfeldt-Jakob disease brains.
Alzheimer Disease
Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk.
Alzheimer Disease
Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A.
Alzheimer Disease
Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats.
Alzheimer Disease
Evidence for irreversible inhibition of glycogen synthase kinase-3? by tideglusib.
Alzheimer Disease
Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation.
Alzheimer Disease
Expression of 14-3-3 transcript isoforms in response to ethanol exposure and their regulation by miRNAs.
Alzheimer Disease
Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection.
Alzheimer Disease
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.
Alzheimer Disease
Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production.
Alzheimer Disease
Flow cytometry-based method to analyze the change in Tau phosphorylation in a hGSK-3beta and hTau over-expressing EcR-293 cell line.
Alzheimer Disease
Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.
Alzheimer Disease
Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.
Alzheimer Disease
Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Alzheimer Disease
Gene-BIT Life Sciences' third annual world congress. Anti-neurodegenerative and anti-inflammation biotherapeutics.
Alzheimer Disease
Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk.
Alzheimer Disease
Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3.
Alzheimer Disease
Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.
Alzheimer Disease
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles.
Alzheimer Disease
Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation.
Alzheimer Disease
Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.
Alzheimer Disease
Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?
Alzheimer Disease
Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.
Alzheimer Disease
Glycogen synthase kinase-3 as drug target: from wallflower to center of attention.
Alzheimer Disease
Glycogen synthase kinase-3 beta and tau genes interact in Parkinson's and Alzheimer's diseases.
Alzheimer Disease
Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium.
Alzheimer Disease
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.
Alzheimer Disease
Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.
Alzheimer Disease
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Alzheimer Disease
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Alzheimer Disease
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease.
Alzheimer Disease
Glycogen Synthase Kinase-3 Maleimide Inhibitors As Potential PET-Tracers for Imaging Alzheimer's Disease: 11C-Synthesis and In Vivo Proof of Concept.
Alzheimer Disease
Glycogen Synthase Kinase-3 Modulates Neurite Outgrowth in Cultured Neurons: Possible Implications for Neurite Pathology in Alzheimer's Disease.
Alzheimer Disease
Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3: a target for novel bipolar disorder treatments.
Alzheimer Disease
Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?
Alzheimer Disease
Glycogen synthase kinase-3?2 has lower phosphorylation activity to tau than glycogen synthase kinase-3?1.
Alzheimer Disease
Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease.
Alzheimer Disease
Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules.
Alzheimer Disease
Granulovacuolar Degeneration Bodies of Alzheimer's Disease Resemble Late-stage Autophagic Organelles.
Alzheimer Disease
GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment.
Alzheimer Disease
GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.
Alzheimer Disease
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
Alzheimer Disease
GSK3 inhibition promotes lysosomal biogenesis and the autophagic degradation of the Amyloid-? Precursor Protein.
Alzheimer Disease
GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals.
Alzheimer Disease
GSK3beta activity modifies the localization and function of presenilin 1.
Alzheimer Disease
GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.
Alzheimer Disease
GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease.
Alzheimer Disease
Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease.
Alzheimer Disease
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.
Alzheimer Disease
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3?.
Alzheimer Disease
Identification of lead small molecule inhibitors of glycogen synthase kinase-3 beta using a fragment-linking strategy.
Alzheimer Disease
Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease.
Alzheimer Disease
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Alzheimer Disease
Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells.
Alzheimer Disease
In silico docking and comparative ADMET profile of different glycogen synthase kinase 3 beta inhibitors as the potential leads for the development of anti-Alzheimer drug therapy.
Alzheimer Disease
In Vitro and In Vivo Evaluation of GSK-3 Radioligands in Alzheimer's Disease: Preliminary Evidence of Sex Differences.
Alzheimer Disease
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta.
Alzheimer Disease
In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors.
Alzheimer Disease
Inactivation of GSK-3beta in okadaic acid-induced neurodegeneration: relevance to Alzheimer's disease.
Alzheimer Disease
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Alzheimer Disease
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.
Alzheimer Disease
Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down syndrome.
Alzheimer Disease
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.
Alzheimer Disease
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Alzheimer Disease
Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.
Alzheimer Disease
Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice.
Alzheimer Disease
Inhibition of casein kinase 1?/?improves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease.
Alzheimer Disease
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3 ameliorates ?-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3: an emerging target in the treatment of traumatic brain injury.
Alzheimer Disease
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity.
Alzheimer Disease
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.
Alzheimer Disease
Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?
Alzheimer Disease
Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation.
Alzheimer Disease
Insight into glycogen synthase kinase-3? inhibitory activity of phyto-constituents from Melissa officinalis: in silico studies.
Alzheimer Disease
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.
Alzheimer Disease
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Alzheimer Disease
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Alzheimer Disease
Is Glucagon-like peptide-1, an agent treating diabetes, a new hope for Alzheimer's disease?
Alzheimer Disease
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Alzheimer Disease
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
Alzheimer Disease
Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer's disease by elevating microRNA-15a and repressing ROCK1 expression.
Alzheimer Disease
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Alzheimer Disease
Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.
Alzheimer Disease
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Alzheimer Disease
Ligand binding study of human PEBP1/RKIP: interaction with nucleotides and Raf-1 peptides evidenced by NMR and mass spectrometry.
Alzheimer Disease
Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.
Alzheimer Disease
Lithium for older adults with bipolar disorder: Should it still be considered a first-line agent?
Alzheimer Disease
Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.
Alzheimer Disease
Lithium Inhibits GSK3? and Augments GluN2A Receptor Expression in the Prefrontal Cortex.
Alzheimer Disease
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
Alzheimer Disease
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.
Alzheimer Disease
Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.
Alzheimer Disease
Lithium: bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium.
Alzheimer Disease
Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease.
Alzheimer Disease
Loss of activated CaMKII at the synapse underlies Alzheimer's disease memory loss.
Alzheimer Disease
LRRK2 G2019S and I2020T mutations are not common in Alzheimer's disease and vascular dementia.
Alzheimer Disease
LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.
Alzheimer Disease
LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil.
Alzheimer Disease
Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model.
Alzheimer Disease
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
Alzheimer Disease
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.
Alzheimer Disease
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.
Alzheimer Disease
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Alzheimer Disease
Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.
Alzheimer Disease
Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.
Alzheimer Disease
Memantine Inhibits Calpain-Mediated Truncation of GSK-3 Induced by NMDA: Implications in Alzheimer's Disease.
Alzheimer Disease
microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.
Alzheimer Disease
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease.
Alzheimer Disease
MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB.
Alzheimer Disease
MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease.
Alzheimer Disease
Microsecond molecular dynamics simulations and dynamic network analysis provide understanding of the allosteric inactivation of GSK3? induced by the L343R mutation.
Alzheimer Disease
Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells.
Alzheimer Disease
Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.
Alzheimer Disease
Molecular dynamics simulation studies of GSK-3? ATP competitive inhibitors: understanding the factors contributing to selectivity.
Alzheimer Disease
Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease.
Alzheimer Disease
Multifunctional Ligands with Glycogen Synthase Kinase 3 Inhibitory Activity as a New Direction in Drug Research for Alzheimer's Disease.
Alzheimer Disease
Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease.
Alzheimer Disease
Mutation analysis of patients with neurodegenerative disorders using NeuroX array.
Alzheimer Disease
Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms.
Alzheimer Disease
Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets.
Alzheimer Disease
Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins.
Alzheimer Disease
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.
Alzheimer Disease
Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide.
Alzheimer Disease
Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.
Alzheimer Disease
Neurotrophins enhance CaMKII activity and rescue amyloid-?-induced deficits in hippocampal synaptic plasticity.
Alzheimer Disease
New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.
Alzheimer Disease
Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer's disease.
Alzheimer Disease
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.
Alzheimer Disease
No association between the LRRK2 G2019S mutation and Alzheimer's disease in Italy.
Alzheimer Disease
No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals.
Alzheimer Disease
Novel 18F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3?.
Alzheimer Disease
Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease.
Alzheimer Disease
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.
Alzheimer Disease
O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Alzheimer Disease
Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice.
Alzheimer Disease
Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy.
Alzheimer Disease
Pathological tau tangles localize to focal cortical dysplasia in older patients.
Alzheimer Disease
Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.
Alzheimer Disease
Pharmacophore feature-based virtual screening for finding potent GSK-3 inhibitors using molecular docking and dynamics simulations.
Alzheimer Disease
Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.
Alzheimer Disease
Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation.
Alzheimer Disease
Phosphorylation of tau by glycogen synthase kinase-3 beta in vitro produces species with similar electrophoretic and immunogenic properties to PHF-tau from Alzheimer's disease brain.
Alzheimer Disease
Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry.
Alzheimer Disease
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.
Alzheimer Disease
Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease.
Alzheimer Disease
PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
Alzheimer Disease
Potential mechanisms involved in the prevention of neurodegenerative diseases by lithium.
Alzheimer Disease
Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.
Alzheimer Disease
Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures.
Alzheimer Disease
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
Alzheimer Disease
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.
Alzheimer Disease
Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice.
Alzheimer Disease
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Alzheimer Disease
Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells.
Alzheimer Disease
Protein kinases A and C regulate amyloid-? degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes.
Alzheimer Disease
Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.
Alzheimer Disease
Radiosynthesis and in Vivo Evaluation of [(11)C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain.
Alzheimer Disease
Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone.
Alzheimer Disease
Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor.
Alzheimer Disease
Rapidly progressive Alzheimer's disease and elevated 14-3-3 proteins in cerebrospinal fluid.
Alzheimer Disease
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease.
Alzheimer Disease
Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders.
Alzheimer Disease
Receptor-based pharmacophore modeling, virtual screening, and molecular docking studies for the discovery of novel GSK-3? inhibitors.
Alzheimer Disease
Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease.
Alzheimer Disease
Regulation and role of brain calcium/calmodulin-dependent protein kinase II.
Alzheimer Disease
Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.
Alzheimer Disease
Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3.
Alzheimer Disease
Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease.
Alzheimer Disease
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Alzheimer Disease
Retracted: "Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy" [Neuroscience 146 (2007) 1640-1651].
Alzheimer Disease
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain.
Alzheimer Disease
Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.
Alzheimer Disease
Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene.
Alzheimer Disease
Rs4878104 contributes to Alzheimer's disease risk and regulates DAPK1 gene expression.
Alzheimer Disease
S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.
Alzheimer Disease
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 ? Inhibitors.
Alzheimer Disease
Screening of potential drug for Alzheimer's disease: a computational study with GSK-3 ? inhibition through virtual screening, docking, and molecular dynamics simulation.
Alzheimer Disease
Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser glycogen synthase kinase-3beta.
Alzheimer Disease
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
Alzheimer Disease
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.
Alzheimer Disease
Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells.
Alzheimer Disease
Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.
Alzheimer Disease
Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3? signaling pathway.
Alzheimer Disease
Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice.
Alzheimer Disease
Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.
Alzheimer Disease
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.
Alzheimer Disease
Steroid-responsive encephalopathy with a peculiar CSF biomarker profile in an 89-year-old man.
Alzheimer Disease
Structural Basis for Achieving GSK-3? Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery.
Alzheimer Disease
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Alzheimer Disease
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta.
Alzheimer Disease
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
Alzheimer Disease
Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3? inhibitors: A critical review.
Alzheimer Disease
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Alzheimer Disease
Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.
Alzheimer Disease
Suppression of Plasmodium berghei parasitemia by LiCl in an animal infection model.
Alzheimer Disease
Suppressive Effects of SuHeXiang Wan on Amyloid-?42-Induced Extracellular Signal-Regulated Kinase Hyperactivation and Glial Cell Proliferation in a Transgenic Drosophila Model of Alzheimer's Disease.
Alzheimer Disease
Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: An fast and atom efficient access to 1-aryl-3-benzylureas.
Alzheimer Disease
Synthesis and biological evaluation of novel 2 (4`-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor.
Alzheimer Disease
Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer's disease.
Alzheimer Disease
Systematic analysis of GSK-3 signaling pathways in aging of cerebral tissue.
Alzheimer Disease
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Alzheimer Disease
Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation.
Alzheimer Disease
Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
Alzheimer Disease
tau kinases in the rat heat shock model: possible implications for Alzheimer disease.
Alzheimer Disease
Tau overexpression in transgenic mice induces glycogen synthase kinase 3beta and beta-catenin phosphorylation.
Alzheimer Disease
Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology.
Alzheimer Disease
Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Alzheimer Disease
Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.
Alzheimer Disease
Tau-tubulin kinase 1 and amyloid-? peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models.
Alzheimer Disease
Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain.
Alzheimer Disease
Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease.
Alzheimer Disease
The ?-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer's Disease.
Alzheimer Disease
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease.
Alzheimer Disease
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Alzheimer Disease
The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies.
Alzheimer Disease
The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.
Alzheimer Disease
The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease.
Alzheimer Disease
The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.
Alzheimer Disease
The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease.
Alzheimer Disease
The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease.
Alzheimer Disease
The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.
Alzheimer Disease
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Alzheimer Disease
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Alzheimer Disease
The neurite retraction induced by lysophosphatidic acid increases Alzheimer's disease-like Tau phosphorylation.
Alzheimer Disease
The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo.
Alzheimer Disease
The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents.
Alzheimer Disease
Therapeutic Targeting of Casein Kinase 1?/? in an Alzheimer's Disease Mouse Model.
Alzheimer Disease
Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study.
Alzheimer Disease
Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer's Disease Links Numerous Treatment Rationales.
Alzheimer Disease
Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy.
Alzheimer Disease
Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.
Alzheimer Disease
Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
Alzheimer Disease
Up-regulation of casein kinase 1? is involved in tau pathogenesis in Alzheimer's disease.
Alzheimer Disease
Up-regulation of Hypoxia-Inducible Factor (HIF) -1alpha and HIF-Target Genes in Cortical Neurons by the Novel Multifunctional Iron Chelator Anti-Alzheimer Drug, M30.
Alzheimer Disease
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.
Alzheimer Disease
Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling.
Alzheimer Disease
Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.
Alzheimer Disease
[A new target for diabetes therapy: advances in the research of glycogen synthase kinase-3 inhibitors]
Alzheimer Disease
[Cytoplasmic casein kinase 2 and its substrate proteins in the brain in Alzheimer's disease]
Alzheimer Disease
[Effects of tanshinone IIA on the expressions of caspase-3, Akt and NF-?B in the brains of rat models of Alzheimer's disease].
Alzheimer Disease
[Eleven years of autopsy on account of Creutzfeldt-Jakob disease in the Netherlands]
Alzheimer Disease
[Protein phosphorylation in the normal nervous system and in Alzheimer's disease]
Alzheimer Disease
[The role of lithium in neurodegenerative diseases: new registries for old actors.]
Amebiasis
EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica.
Ameloblastoma
Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review.
Amnesia
Possible interaction of hippocampal nitric oxide and calcium/calmodulin-dependent protein kinase II on reversal of spatial memory impairment induced by morphine.
Amnesia, Retrograde
Systemic administration of ACTH or vasopressin reverses the amnestic effect of posttraining beta-endorphin or electroconvulsive shock but not that of intrahippocampal infusion of protein kinase inhibitors.
amp deaminase deficiency
AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
Amyloidosis
Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.
Amyotrophic Lateral Sclerosis
14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
14-3-3 proteins in Lewy body-like hyaline inclusions in a patient with familial amyotrophic lateral sclerosis with a two-base pair deletion in the Cu/Zn superoxide dismutase (SOD1) gene.
Amyotrophic Lateral Sclerosis
14-3-3 proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord.
Amyotrophic Lateral Sclerosis
Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Amyotrophic Lateral Sclerosis
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Amyotrophic Lateral Sclerosis
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Amyotrophic Lateral Sclerosis
Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model.
Amyotrophic Lateral Sclerosis
Computer-aided scaffold hopping to identify a novel series of casein kinase 1 delta (CK1d) inhibitors for amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Amyotrophic Lateral Sclerosis
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Amyotrophic Lateral Sclerosis
Immunohistochemical expression of IGF-I and GSK in the spinal cord of Kii and Guamanian ALS patients.
Amyotrophic Lateral Sclerosis
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
Amyotrophic Lateral Sclerosis
Novel group-based QSAR and combinatorial design of CK-1? inhibitors as neuroprotective agents.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amyotrophic Lateral Sclerosis
Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies.
Amyotrophic Lateral Sclerosis
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.
Amyotrophic Lateral Sclerosis
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.
Amyotrophic Lateral Sclerosis
Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 ? Inhibitors.
Amyotrophic Lateral Sclerosis
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).
Amyotrophic Lateral Sclerosis
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Amyotrophic Lateral Sclerosis
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Amyotrophic Lateral Sclerosis
The potential role of glycogen synthase kinase 3 inhibitors as amyotrophic lateral sclerosis pharmacological therapy.
Anaphylaxis
ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
Anaplasmosis
Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection.
Anemia
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Anemia
p27(KIP1) and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice.
Anemia
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.
Anemia
Protein kinases and membrane protein phosphorylation in normal and abnormal human erythrocytes: variation related to mean cell age.
Anemia, Hemolytic
ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.
Anemia, Sickle Cell
Protein kinases and membrane protein phosphorylation in normal and abnormal human erythrocytes: variation related to mean cell age.
Aneurysm
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aneurysm
[Effect of thyroxine on the expression of HIF-1? after aneurysmal subarachnoid hemorrhage in rat brain and its mechanism].
Aneurysm, Dissecting
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Angiomyolipoma
Incremental Expression of 14-3-3 Protein Beta/Alpha in Urine Correlates with Advanced Stage and Poor Survival in Patients with Clear Cell Renal Cell Carcinoma.
Angiomyolipoma
Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma.
Ankylosis
JNK phosphorylation promotes degeneration of cervical endplate chondrocytes through down-regulation of the expression of ANK in humans.
Anosmia
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Anosmia
Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.
Anosmia
Cognition among individuals along a spectrum of increased risk for Parkinson's disease.
Anosmia
Olfactory deficits and cardiac (123) I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations.
Anovulation
Effects of seasonal adiposity on ovarian activity of Vespertilionid bat, Scotophilus heathi: proteomics analysis.
Anthrax
Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages.
Anthrax
Regulatory interactions of a virulence-associated serine/threonine phosphatase-kinase pair in Bacillus anthracis.
Anthrax
The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells.
Aortic Aneurysm
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Aortic Aneurysm
Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis.
Aortic Aneurysm
Effect of miR-126 on the Proliferation and Migration of Vascular Smooth Muscle Cells in Aortic Aneurysm Mice Under PI3K/AKT/mTOR Signaling Pathway.
Aortic Aneurysm
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aortic Aneurysm
Rosiglitazone negatively regulates c-Jun N-terminal kinase and toll-like receptor 4 proinflammatory signalling during initiation of experimental aortic aneurysms.
Aortic Aneurysm, Abdominal
Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis.
Aortic Aneurysm, Abdominal
Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor ?B activation.
Aortic Aneurysm, Abdominal
Identification of c-Jun N-terminal kinase as a therapeutic target for abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice.
Aortic Aneurysm, Abdominal
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase.
Aortic Aneurysm, Abdominal
SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration.
Aortic Aneurysm, Thoracic
14-3-3 in Thoracic Aortic Aneurysms: Identification of a Novel Autoantigen in Large Vessel Vasculitis.
Aortic Aneurysm, Thoracic
Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis.
Aortic Aneurysm, Thoracic
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aortic Diseases
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome.
Aortic Valve Disease
High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1.
Aortic Valve Insufficiency
Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, ?-arrestin-2, and CaMKII in mice with aortic regurgitation.
Aphasia, Primary Progressive
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Aphasia, Primary Progressive
Corticobasal syndrome and primary progressive aphasia as manifestations of lrrk2 gene mutations.
Apnea
A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction.
Apnea
Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.
Arrhythmias, Cardiac
Antiarrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats.
Arrhythmias, Cardiac
Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits KATP channels through CaMKII activation.
Arrhythmias, Cardiac
Calcium/Calmodulin-dependent Kinase II Regulation of Cardiac Ion Channels.
Arrhythmias, Cardiac
Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure.
Arrhythmias, Cardiac
Calm down when the heart is stressed: Inhibiting calmodulin-dependent protein kinase II for antiarrhythmias.
Arrhythmias, Cardiac
Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.
Arrhythmias, Cardiac
CaMKII activation promotes cardiac electrical remodeling and increases the susceptibility to arrhythmia induction in high fat diet-fed mice with hyperlipidemia conditions.
Arrhythmias, Cardiac
CaMKII Activation Promotes Cardiac Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in High-fat Diet-Fed Mice With Hyperlipidemia Conditions: Erratum.
Arrhythmias, Cardiac
CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.
Arrhythmias, Cardiac
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Arrhythmias, Cardiac
CaMKII-dependent late Na+ current increases electrical dispersion and arrhythmia in ischemia-reperfusion.
Arrhythmias, Cardiac
Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators.
Arrhythmias, Cardiac
Cardiac CaMKII? and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells.
Arrhythmias, Cardiac
Computational biology in the study of cardiac ion channels and cell electrophysiology.
Arrhythmias, Cardiac
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Arrhythmias, Cardiac
Disruption of calcium homeostasis by cardiac-specific over-expression of PPAR-? in mice: A role in ventricular arrhythmia.
Arrhythmias, Cardiac
Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function.
Arrhythmias, Cardiac
Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II.
Arrhythmias, Cardiac
Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Arrhythmias, Cardiac
Glioblastoma following treatment with fingolimod for relapsing-remitting multiple sclerosis.
Arrhythmias, Cardiac
High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice.
Arrhythmias, Cardiac
HMMerThread: Detecting Remote, Functional Conserved Domains in Entire Genomes by Combining Relaxed Sequence-Database Searches with Fold Recognition.
Arrhythmias, Cardiac
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes.
Arrhythmias, Cardiac
Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.
Arrhythmias, Cardiac
Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor.
Arrhythmias, Cardiac
KN-93, A CaMKII inhibitor, suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR.
Arrhythmias, Cardiac
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Arrhythmias, Cardiac
Maximum phosphorylation of the cardiac ryanodine receptor at serine-2809 by protein kinase a produces unique modifications to channel gating and conductance not observed at lower levels of phosphorylation.
Arrhythmias, Cardiac
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Arrhythmias, Cardiac
Multiple downstream proarrhythmic targets for calmodulin kinase II: moving beyond an ion channel-centric focus.
Arrhythmias, Cardiac
Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors.
Arrhythmias, Cardiac
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.
Arrhythmias, Cardiac
Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.
Arrhythmias, Cardiac
Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia.
Arrhythmias, Cardiac
Proarrhythmic defects in Timothy syndrome require calmodulin kinase II.
Arrhythmias, Cardiac
Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits.
Arrhythmias, Cardiac
Sustained CaMKII activity mediates transient oxidative stress-induced long-term facilitation of L-type Ca(2+) current in cardiomyocytes.
Arrhythmias, Cardiac
The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity.
Arrhythmias, Cardiac
The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet.
Arrhythmias, Cardiac
The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.
Arrhythmias, Cardiac
Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.
Arrhythmias, Cardiac
[Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein].
Arsenic Poisoning
Differential expression of serum proteins in rats subchronically exposed to arsenic identified by iTRAQ-based proteomic technology-14-3-3 ? protein to serve as a potential biomarker.
Arteriosclerosis Obliterans
Drug discovery by formulation design and innovative drug delivery systems (DDS).
Arteriovenous Malformations
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Arteritis
Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis.
Arthritis
A hyperactivating proinflammatory RIPK2 allele associated with early-onset osteoarthritis.
Arthritis
Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis.
Arthritis
BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
Arthritis
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.
Arthritis
Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior.
Arthritis
Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition.
Arthritis
Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior.
Arthritis
Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse.
Arthritis
Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.
Arthritis
Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening.
Arthritis
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
Arthritis
In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.
Arthritis
Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue.
Arthritis
Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.
Arthritis
JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.
Arthritis
Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis.
Arthritis
Micro RNAs 26b, 20a inversely correlate with GSK-3 ?/NF-?B/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis.
Arthritis
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway.
Arthritis
Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes.
Arthritis
Sympathetic Nerve Hyperactivity in the Spleen: Causal for Nonpathogenic-Driven Chronic Immune-Mediated Inflammatory Diseases (IMIDs)?
Arthritis, Experimental
Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis.
Arthritis, Experimental
Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.
Arthritis, Experimental
Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis.
Arthritis, Experimental
Low dose IL-2 suppress osteoclastogenesis in collagen-induced arthritis via JNK dependent pathway.
Arthritis, Experimental
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Arthritis, Experimental
[Effect of Xinfeng Capsule on Beclin1/PI3K-AKT-mTOR of Adjuvant Arthritis Rats].
Arthritis, Rheumatoid
Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis.
Arthritis, Rheumatoid
Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.
Arthritis, Rheumatoid
Comparison of Serum Levels of 14-3-3 ETA Proteins between Rheumatoid Arthritis, Osteoarthritis and Normal Controls.
Arthritis, Rheumatoid
Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics: Two Examples of Rheumatoid Arthritis.
Arthritis, Rheumatoid
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.
Arthritis, Rheumatoid
Diagnostic accuracy of 14-3-3 ? protein in rheumatoid arthritis: A meta-analysis.
Arthritis, Rheumatoid
DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis.
Arthritis, Rheumatoid
Exploration of a binding mode of benzothiazol-2-yl acetonitrile pyrimidine core based derivatives as potent c-Jun N-terminal kinase-3 inhibitors and 3D-QSAR analyses.
Arthritis, Rheumatoid
Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Arthritis, Rheumatoid
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
Arthritis, Rheumatoid
Impact of rheumatoid arthritis-associated HLA-DRbeta1 subtypes on protein kinase A signaling.
Arthritis, Rheumatoid
Inflammatory Diseases Among Norwegian LRRK2 Mutation Carriers. A 15-Years Follow-Up of a Cohort.
Arthritis, Rheumatoid
Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue.
Arthritis, Rheumatoid
Long non-coding RNA growth arrest-specific transcript 5 regulates rheumatoid arthritis by targeting homeodomain-interacting protein kinase 2.
Arthritis, Rheumatoid
MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis, Rheumatoid
MicroRNA-27b-3p inhibits apoptosis of chondrocyte in rheumatoid arthritis by targeting HIPK2.
Arthritis, Rheumatoid
New BRAF (v raf murine sarcoma viral oncogene homologue B1) mutation in rheumatoid arthritis.
Arthritis, Rheumatoid
Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations.
Arthritis, Rheumatoid
PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.
Arthritis, Rheumatoid
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Arthritis, Rheumatoid
Reduction of SR Ca(2+) leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.
Arthritis, Rheumatoid
Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis.
Arthritis, Rheumatoid
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway.
Arthritis, Rheumatoid
Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.
Arthritis, Rheumatoid
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Arthritis, Rheumatoid
Secreted frizzled-related protein 5 suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through down-regulation of c-Jun N-terminal kinase.
Arthritis, Rheumatoid
Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.
Arthritis, Rheumatoid
[Effect of rheumatoid arthritis associated HLA-DRbeta1 subtypes on protein kinase A signaling]
Ascorbic Acid Deficiency
Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare.
Ascorbic Acid Deficiency
Dietary vitamin C deficiency depresses the growth, head kidney and spleen immunity and structural integrity by regulating NF-?B, TOR, Nrf2, apoptosis and MLCK signaling in young grass carp (Ctenopharyngodon idella).
Ascorbic Acid Deficiency
Vitamin C deficiency aggravates tumor necrosis factor ?-induced insulin resistance.
Asthenozoospermia
Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormality of the flagella.
Asthma
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.
Asthma
Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma.
Asthma
Glucocorticoid- and Protein Kinase A- dependent Transcriptome Regulation in Airway Smooth Muscle.
Asthma
Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.
Asthma
Inhibition of Glycogen Synthase Kinase-3{beta} Is Sufficient for Airway Smooth Muscle Hypertrophy.
Asthma
Inhibition of p21-activated kinase 1 attenuates the cardinal features of asthma through suppressing the lymph node homing of dendritic cells.
Asthma
Interactive Roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases.
Asthma
Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma.
Asthma
N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression.
Asthma
NGF/TrkA-mediated Kidins220/ARMS signaling activated in the allergic airway challenge in mice.
Asthma
NOD1 sensing of house dust mite-derived microbiota promotes allergic experimental asthma.
Asthma
Receptor Interacting Protein 2 (RIP2) Is Dispensable for OVA-Induced Airway Inflammation in Mice.
Asthma
Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients.
Asthma
Titanium dioxide particles modulate epithelial barrier protein, Claudin 7 in asthma.
Asthma
[Expression of Rock2 and TGF-?1 mRNA and glucocorticoid intervention in asthmatic rats].
Asthma
[Regulation of acupuncture on expression of AKT protein in lung tissues of asthma rats].
Asthma
[Role of c-Jun N-terminal kinase signal transduction pathway in the course of airway remodeling of asthma rat]
Astrocytoma
14-3-3? regulates the proliferation of glioma cells through the GSK3?/?-catenin signaling pathway.
Astrocytoma
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
Astrocytoma
Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
Astrocytoma
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.
Astrocytoma
Differential Expression of the Tumor Suppressor A-Kinase Anchor Protein 12 in Human Diffuse and Pilocytic Astrocytomas Is Regulated by Promoter Methylation.
Astrocytoma
Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction.
Astrocytoma
Down-regulation of 14-3-3? exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP-Wnt pathway.
Astrocytoma
Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.
Astrocytoma
Expression, association with clinicopathological features and prognostic potential of CEP55, p-Akt, FoxM1 and MMP-2 in astrocytoma.
Astrocytoma
High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.
Astrocytoma
Identification of 14-3-3 protein isoforms in human astrocytoma by immunohistochemistry.
Astrocytoma
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
Astrocytoma
Implication of 14-3-3? and 14-3-3?/? in proteasome inhibition-induced apoptosis of glioma cells.
Astrocytoma
Methylation Patterns of DKK1, DKK3 and GSK3? Are Accompanied with Different Expression Levels in Human Astrocytoma.
Astrocytoma
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
Astrocytoma
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.
Astrocytoma
Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells.
Astrocytoma
Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells.
Astrocytoma
Proteomic analysis of low- to high-grade astrocytomas reveals an alteration of the expression level of raf kinase inhibitor protein and nucleophosmin.
Astrocytoma
Rapamycin inhibits substance P-induced protein synthesis and phosphorylation of PHAS-I (4E-BP1) and p70 S6 kinase (p70(S6K)) in human astrocytoma cells.
Astrocytoma
Regulation of connexin 43 and microRNA expression via ?2-adrenoceptor signaling in 1321N1 astrocytoma cells.
Astrocytoma
Selective ?2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac.
Astrocytoma
Up-regulation of protein l-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization.
Astrocytoma
[The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325]
Ataxia
Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells.
Ataxia
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.
Ataxia
Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.
Ataxia
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.
Ataxia
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2.
Ataxia
Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage.
Ataxia
Diffusion-weighted MRI in Creutzfeldt-Jakob disease: a better diagnostic marker than CSF protein 14-3-3?
Ataxia
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
Ataxia
DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals.
Ataxia
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Ataxia
Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine.
Ataxia
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Ataxia
Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells.
Ataxia
Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway.
Ataxia
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
Ataxia
Nuclear factor-like factor 2-antioxidant activation through the action of ataxia telangiectasia-mutated serine/threonine kinase is essential to counteract oxidative stress in bovine mammary epithelial cells.
Ataxia
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ataxia
Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18.
Ataxia
The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations.
Ataxia
The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage.
Ataxia
The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
Ataxia
The Mismatch-Binding Factor MutS? Can Mediate ATR Activation in Response to DNA Double-Strand Breaks.
Ataxia
Topoisomerase II?-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.
Ataxia Telangiectasia
2-Deoxy-D-glucose and ferulic acid modulates radiation response signaling in non-small cell lung cancer cells.
Ataxia Telangiectasia
24 targeted disruption of ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer.
Ataxia Telangiectasia
3F-Box protein 32 degrades ataxia telangiectasia and Rad3-related and regulates DNA damage response induced by gemcitabine in pancreatic cancer.
Ataxia Telangiectasia
4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway.
Ataxia Telangiectasia
5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Ataxia Telangiectasia
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
Ataxia Telangiectasia
53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response.
Ataxia Telangiectasia
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
Ataxia Telangiectasia
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
Ataxia Telangiectasia
53BP1 is limiting for nonhomologous end-joining in ATM-deficient cells subjected to oncogenic stress or radiation.
Ataxia Telangiectasia
53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells.
Ataxia Telangiectasia
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.
Ataxia Telangiectasia
53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope.
Ataxia Telangiectasia
7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells.
Ataxia Telangiectasia
?-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway.
Ataxia Telangiectasia
?-H2AX and phosphorylated ATM focus formation in cancer cells after laser plasma X irradiation.
Ataxia Telangiectasia
?-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Ataxia Telangiectasia
?-Radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines.
Ataxia Telangiectasia
A 20-year perspective on the International Fanconi Anemia Registry (IFAR).
Ataxia Telangiectasia
A Case of Therapy-Related Acute Myeloid Leukemia in a Patient With Heterozygous Mutations in the Ataxia Telangiectasia Mutated Gene.
Ataxia Telangiectasia
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.
Ataxia Telangiectasia
A coordinated DNA damage response promotes adult quiescent neural stem cell activation.
Ataxia Telangiectasia
A critical role for topoisomerase IIb and DNA double strand breaks in transcription.
Ataxia Telangiectasia
A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells.
Ataxia Telangiectasia
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-?B activation.
Ataxia Telangiectasia
A developmental role for ataxia-telangiectasia mutated in protecting the embryo from spontaneous and phenytoin-enhanced embryopathies in culture.
Ataxia Telangiectasia
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.
Ataxia Telangiectasia
A dynamic model for the p53 stress response networks under ion radiation.
Ataxia Telangiectasia
A functional link between SIRT1 deacetylase and NBS1 in DNA damage response.
Ataxia Telangiectasia
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
Ataxia Telangiectasia
A germline chromothripsis event stably segregating in 11 individuals through three generations.
Ataxia Telangiectasia
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.
Ataxia Telangiectasia
A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila.
Ataxia Telangiectasia
A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers.
Ataxia Telangiectasia
A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.
Ataxia Telangiectasia
A majority of human melanoma cell lines exhibits an s phase-specific defect in excision of UV-induced DNA photoproducts.
Ataxia Telangiectasia
A mathematical model of P53 gene regulatory networks under radiotherapy.
Ataxia Telangiectasia
A meta-analysis of the relationship between ataxia-telangiectasia mutated gene polymorphisms and lung cancer susceptibility.
Ataxia Telangiectasia
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.
Ataxia Telangiectasia
A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation.
Ataxia Telangiectasia
A Mutant Allele of MRE11 Found in Mismatch Repair-deficient Tumor Cells Suppresses the Cellular Response to DNA Replication Fork Stress in a Dominant Negative Manner.
Ataxia Telangiectasia
A novel 1-((3-(2-toluyl)-4,5-dihydroisoxazol-5-yl)methyl)-4-(trifluoromethyl)pyrimidin-2(1H)-one activates intrinsic mitochondria-dependent pathway and decreases angiogenesis in PC-3 cells.
Ataxia Telangiectasia
A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks.
Ataxia Telangiectasia
A Novel Anticancer Agent, 8-Methoxypyrimido[4',5':4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways.
Ataxia Telangiectasia
A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells.
Ataxia Telangiectasia
A Novel ATM Pathogenic Variant in an Italian Woman with Gallbladder Cancer.
Ataxia Telangiectasia
A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.
Ataxia Telangiectasia
A novel ATM/TP53/p21-mediated checkpoint only activated by chronic ?-irradiation.
Ataxia Telangiectasia
A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.
Ataxia Telangiectasia
A Novel Homozygous Variant of SETX Causes Ataxia with Oculomotor Apraxia Type 2.
Ataxia Telangiectasia
A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.
Ataxia Telangiectasia
A novel mathematical model of ATM/p53/NF- ?B pathways points to the importance of the DDR switch-off mechanisms.
Ataxia Telangiectasia
A novel morphometry system automatically assessing the growth and regeneration of intestinal organoids.
Ataxia Telangiectasia
A novel mutation in ATM gene in a Saudi female with ataxia telangiectasia.
Ataxia Telangiectasia
A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation.
Ataxia Telangiectasia
A Novel Oral Astaxanthin Nanoemulsion from Haematococcus pluvialis Induces Apoptosis in Lung Metastatic Melanoma.
Ataxia Telangiectasia
A novel pathogenic variant in an Iranian Ataxia telangiectasia family revealed by next-generation sequencing followed by in silico analysis.
Ataxia Telangiectasia
A Novel Splice Site Mutation of the ATM Gene Associated with Ataxia Telangiectasia.
Ataxia Telangiectasia
A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa.
Ataxia Telangiectasia
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Ataxia Telangiectasia
A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4.
Ataxia Telangiectasia
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
Ataxia Telangiectasia
A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation.
Ataxia Telangiectasia
A polymorphism in the ATM gene modulates the penetrance of hereditary non-polyposis colorectal cancer.
Ataxia Telangiectasia
A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas.
Ataxia Telangiectasia
A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.
Ataxia Telangiectasia
A role for ataxia telangiectasia mutated in insulin-independent stimulation of glucose transport.
Ataxia Telangiectasia
A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls.
Ataxia Telangiectasia
A Soft Coral-Derived Compound, 11-Dehydrosinulariolide, Induces G2/M Cell Cycle Arrest and Apoptosis in Small Cell Lung Cancer.
Ataxia Telangiectasia
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome.
Ataxia Telangiectasia
A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes.
Ataxia Telangiectasia
A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma.
Ataxia Telangiectasia
A systematic review of the prevalence of DNA damage response gene mutations in prostate cancer.
Ataxia Telangiectasia
Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer.
Ataxia Telangiectasia
Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia.
Ataxia Telangiectasia
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
Ataxia Telangiectasia
Aberrant sensing of extracellular Ca2+ by cultured ataxia telangiectasia fibroblasts.
Ataxia Telangiectasia
Aberrant TCR? rearrangement underlies the T cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.
Ataxia Telangiectasia
Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.
Ataxia Telangiectasia
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.
Ataxia Telangiectasia
Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.
Ataxia Telangiectasia
Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis.
Ataxia Telangiectasia
Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX.
Ataxia Telangiectasia
Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL).
Ataxia Telangiectasia
Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer.
Ataxia Telangiectasia
Accumulation of apoptosis-insensitive human bone marrow-mesenchymal stromal cells after long-term expansion.
Ataxia Telangiectasia
Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression.
Ataxia Telangiectasia
Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally.
Ataxia Telangiectasia
Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic.
Ataxia Telangiectasia
Activation of an ataxia telangiectasia mutation-dependent intra-S-phase checkpoint by anti-tumour drugs in HL-60 and human lymphoblastoid cells.
Ataxia Telangiectasia
Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks.
Ataxia Telangiectasia
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.
Ataxia Telangiectasia
Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies.
Ataxia Telangiectasia
Activation of ATM-c-IAP1 Pathway Mediates the Protective Effects of Estradiol in Human Vascular Endothelial Cells Exposed to Intermittent Hypoxia.
Ataxia Telangiectasia
Activation of ATM-Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosis in HeLa cells.
Ataxia Telangiectasia
Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A.
Ataxia Telangiectasia
Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus.
Ataxia Telangiectasia
Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.
Ataxia Telangiectasia
Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.
Ataxia Telangiectasia
Activation of interferon-stimulated genes by {gamma}-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway.
Ataxia Telangiectasia
Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation.
Ataxia Telangiectasia
Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease.
Ataxia Telangiectasia
Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.
Ataxia Telangiectasia
Activation of the phosphorylation of ATM contributes to radioresistance of glioma stem cells.
Ataxia Telangiectasia
Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage.
Ataxia Telangiectasia
Acute Lymphoblastic Leukemia in Early Childhood as the Presenting Sign of Ataxia-Telangiectasia Variant.
Ataxia Telangiectasia
Acute Megakaryoblastic Leukemia with Myelodysplasia-related Changes Associated with ATM Gene Deletion.
Ataxia Telangiectasia
Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR.
Ataxia Telangiectasia
Adaptive response and the influence of ageing: effects of low-dose irradiation on cell growth of cultured glial cells.
Ataxia Telangiectasia
Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor related cytotoxicity.
Ataxia Telangiectasia
Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity.
Ataxia Telangiectasia
Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy.
Ataxia Telangiectasia
Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins.
Ataxia Telangiectasia
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition.
Ataxia Telangiectasia
ALDH1A1 Deficiency in Gorlin Syndrome Suggests a Central Role for Retinoic Acid and ATM Deficits in Radiation Carcinogenesis.
Ataxia Telangiectasia
Allele and genotype frequency of a genetic variant in ataxia telangiectasia mutated gene affecting glycemic response to metformin in South Indian population.
Ataxia Telangiectasia
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models.
Ataxia Telangiectasia
Allogeneic Stem Cell Transplantation after Fanconi Anemia Conditioning in Children with Ataxia-Telangiectasia Results in Stable T Cell Engraftment and Lack of Infections despite Mixed Chimerism.
Ataxia Telangiectasia
Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function.
Ataxia Telangiectasia
ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156.
Ataxia Telangiectasia
Alteration of the ATM gene occurs in gastric cancer cell lines and primary tumors associated with cellular response to DNA damage.
Ataxia Telangiectasia
Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin.
Ataxia Telangiectasia
Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma.
Ataxia Telangiectasia
Alterations of Nuclear Architecture and Epigenetic Signatures during African Swine Fever Virus Infection.
Ataxia Telangiectasia
Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
Ataxia Telangiectasia
AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway.
Ataxia Telangiectasia
An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM.
Ataxia Telangiectasia
An ATM-independent S-phase checkpoint response involves CHK1 pathway.
Ataxia Telangiectasia
An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.
Ataxia Telangiectasia
An essential function for NBS1 in the prevention of ataxia and cerebellar defects.
Ataxia Telangiectasia
An Exploratory Study of Radiation Dermatitis in Breast Cancer Patients.
Ataxia Telangiectasia
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
Ataxia Telangiectasia
Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway.
Ataxia Telangiectasia
Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns.
Ataxia Telangiectasia
Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment.
Ataxia Telangiectasia
Analysis of chromosomal aberrations and ?H2A.X foci to identify radiation-sensitive ataxia-telangiectasia patients.
Ataxia Telangiectasia
Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.
Ataxia Telangiectasia
Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry.
Ataxia Telangiectasia
Analyzing ATM Function by Electroporation of Endonucleases and Immunofluorescence Microscopy.
Ataxia Telangiectasia
Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer.
Ataxia Telangiectasia
Antaxia-telangiectasia mutated gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers.
Ataxia Telangiectasia
Anthracyclines induce DNA damage response-mediated protection against severe sepsis.
Ataxia Telangiectasia
Anti-malarial atovaquone exhibits anti-tumor effects by inducing DNA damage in hepatocellular carcinoma.
Ataxia Telangiectasia
Anti-proliferative effect of isorhamnetin on HeLa cells through inducing G2/M cell cycle arrest.
Ataxia Telangiectasia
Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells.
Ataxia Telangiectasia
Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Ataxia Telangiectasia
Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity.
Ataxia Telangiectasia
Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.
Ataxia Telangiectasia
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis.
Ataxia Telangiectasia
Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells.
Ataxia Telangiectasia
Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk.
Ataxia Telangiectasia
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses.
Ataxia Telangiectasia
Apigenin restores impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B radiation.
Ataxia Telangiectasia
Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress.
Ataxia Telangiectasia
APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.
Ataxia Telangiectasia
Arabidopsis ATM and ATR kinases prevent propagation of genome damage caused by telomere dysfunction.
Ataxia Telangiectasia
Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
Ataxia Telangiectasia
Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia?
Ataxia Telangiectasia
Are polymorphisms of the ataxia telangiectasia mutated gene associated with breast cancer risk?
Ataxia Telangiectasia
Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
Ataxia Telangiectasia
Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.
Ataxia Telangiectasia
Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression.
Ataxia Telangiectasia
ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis.
Ataxia Telangiectasia
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
Ataxia Telangiectasia
Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells.
Ataxia Telangiectasia
Artemis-dependent DNA double-strand break formation at stalled replication forks.
Ataxia Telangiectasia
Arterial "inflammaging" drives vascular calcification in children on dialysis.
Ataxia Telangiectasia
ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation.
Ataxia Telangiectasia
Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique.
Ataxia Telangiectasia
Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.
Ataxia Telangiectasia
Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.
Ataxia Telangiectasia
Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men.
Ataxia Telangiectasia
Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females.
Ataxia Telangiectasia
Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan.
Ataxia Telangiectasia
Association between ATM gene polymorphisms, lung cancer susceptibility and radiation-induced pneumonitis: a meta-analysis.
Ataxia Telangiectasia
Association between ATM polymorphisms and cancer risk: a meta-analysis.
Ataxia Telangiectasia
Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls.
Ataxia Telangiectasia
Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility.
Ataxia Telangiectasia
Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies.
Ataxia Telangiectasia
Association between the rs189037 single nucleotide polymorphism in the ATM gene promoter and cognitive impairment.
Ataxia Telangiectasia
Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma.
Ataxia Telangiectasia
Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.
Ataxia Telangiectasia
Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy.
Ataxia Telangiectasia
Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes.
Ataxia Telangiectasia
Association of the ATM gene polymorphisms with papillary thyroid cancer.
Ataxia Telangiectasia
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer.
Ataxia Telangiectasia
Associations of ATM Polymorphisms With Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Receiving Radiation Therapy.
Ataxia Telangiectasia
Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand.
Ataxia Telangiectasia
Ataxia telangiectasia heterozygotes and patients display increased fluidity and decrease in contents of sulfhydryl groups in red blood cell membranes.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence.
Ataxia Telangiectasia
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.
Ataxia Telangiectasia
Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated coordinates the ovarian DNA repair and atresia-initiating response to phosphoramide mustard.
Ataxia Telangiectasia
Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity.
Ataxia Telangiectasia
Ataxia telangiectasia mutated deficiency does not result in genetic susceptibility to 50?Hz magnetic fields exposure in mouse embryonic fibroblasts.
Ataxia Telangiectasia
Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy.
Ataxia Telangiectasia
Ataxia telangiectasia mutated expression and activation in the testis.
Ataxia Telangiectasia
Ataxia telangiectasia mutated germline pathogenic variant in adrenocortical carcinoma.
Ataxia Telangiectasia
Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity.
Ataxia Telangiectasia
Ataxia telangiectasia mutated influences cytochrome c oxidase activity.
Ataxia Telangiectasia
Ataxia telangiectasia mutated inhibitor-loaded copper sulfide nanoparticles for low-temperature photothermal therapy of hepatocellular carcinoma.
Ataxia Telangiectasia
Ataxia telangiectasia mutated inhibits oxidative stress-induced apoptosis by regulating heme oxygenase-1 expression.
Ataxia Telangiectasia
Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Ataxia Telangiectasia
Ataxia telangiectasia mutated is essential during adult neurogenesis.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase deficiency impairs the autophagic response early during myocardial infarction.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase in the heart: currency for myocyte apoptosis.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase is an autophagic balancer at the onset of heart failure.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Kinase Mediates NF-?B Serine 276 Phosphorylation and Interferon Expression via the IRF7-RIG-I Amplification Loop in Paramyxovirus Infection.
Ataxia Telangiectasia
Ataxia telangiectasia mutated kinase plays a protective role in ?-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.
Ataxia Telangiectasia
Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Protein Kinase: A Potential Master Puppeteer of Oxidative Stress-Induced Metabolic Recycling.
Ataxia Telangiectasia
Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer.
Ataxia Telangiectasia
Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.
Ataxia Telangiectasia
Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage.
Ataxia Telangiectasia
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Ataxia Telangiectasia
Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage.
Ataxia Telangiectasia
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Ataxia Telangiectasia
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in Rats.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated and Rad3-related kinase (ATR) is activated by mild hypothermia in mammalian cells and subsequently activates p53.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated interactor regulates head and neck cancer metastasis via KRas expression.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated kinase: a potential new target for suppressing inflammation in heart failure?
Ataxia Telangiectasia
Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer.
Ataxia Telangiectasia
Ataxia-Telangiectasia Presenting as Cerebral Palsy and Recurrent Wheezing: A Case Report.
Ataxia Telangiectasia
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor ? light chain enhancer of activated B cells (NF?B) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Ataxia Telangiectasia
Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands.
Ataxia Telangiectasia
Ataxia-telangiectasia: A review of clinical features and molecular pathology.
Ataxia Telangiectasia
Ataxia-telangiectasia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management.
Ataxia Telangiectasia
ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis.
Ataxia Telangiectasia
ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
Ataxia Telangiectasia
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.
Ataxia Telangiectasia
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Ataxia Telangiectasia
ATM activation is impaired in human cells defective in RecQL4 helicase activity.
Ataxia Telangiectasia
ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.
Ataxia Telangiectasia
ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage.
Ataxia Telangiectasia
ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans.
Ataxia Telangiectasia
ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks.
Ataxia Telangiectasia
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.
Ataxia Telangiectasia
ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in skeletal muscle.
Ataxia Telangiectasia
ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo.
Ataxia Telangiectasia
ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells.
Ataxia Telangiectasia
ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance.
Ataxia Telangiectasia
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Ataxia Telangiectasia
ATM controls DNA repair and mitochondria transfer between neighboring cells.
Ataxia Telangiectasia
ATM couples replication stress and metabolic reprogramming during cellular senescence.
Ataxia Telangiectasia
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.
Ataxia Telangiectasia
ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.
Ataxia Telangiectasia
ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes.
Ataxia Telangiectasia
ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.
Ataxia Telangiectasia
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Ataxia Telangiectasia
ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.
Ataxia Telangiectasia
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.
Ataxia Telangiectasia
ATM Expression as a Prognostic Marker in Patients With Advanced Biliary Tract Cancer Treated With First-line Gemcitabine and Platinum Chemotherapy.
Ataxia Telangiectasia
ATM expression is attenuated by promoter hypermethylation in human ovarian endometriotic stromal cells.
Ataxia Telangiectasia
ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency.
Ataxia Telangiectasia
ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis.
Ataxia Telangiectasia
ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection.
Ataxia Telangiectasia
ATM functions at the peroxisome to induce pexophagy in response to ROS.
Ataxia Telangiectasia
ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances.
Ataxia Telangiectasia
ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs.
Ataxia Telangiectasia
ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy.
Ataxia Telangiectasia
Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching.
Ataxia Telangiectasia
Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.
Ataxia Telangiectasia
ATM in oral carcinogenesis: association with clinicopathological features.
Ataxia Telangiectasia
ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination.
Ataxia Telangiectasia
ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines.
Ataxia Telangiectasia
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation.
Ataxia Telangiectasia
ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest.
Ataxia Telangiectasia
ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation.
Ataxia Telangiectasia
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.
Ataxia Telangiectasia
ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells.
Ataxia Telangiectasia
ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase ? Deficiency-Dependent Manner.
Ataxia Telangiectasia
ATM is a key driver of NF-?B-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Ataxia Telangiectasia
ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism.
Ataxia Telangiectasia
ATM is activated by mitotic stress and suppresses centrosome amplification in primary but not in tumor cells.
Ataxia Telangiectasia
ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation.
Ataxia Telangiectasia
ATM is required for efficient recombination between immunoglobulin switch regions.
Ataxia Telangiectasia
ATM is required for the cellular response to thymidine induced replication fork stress.
Ataxia Telangiectasia
ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage.
Ataxia Telangiectasia
ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks.
Ataxia Telangiectasia
ATM kinase activity is regulated by ATP-driven conformational changes in the MRN complex.
Ataxia Telangiectasia
ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis.
Ataxia Telangiectasia
ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.
Ataxia Telangiectasia
ATM kinase regulates tumor immunoreactions in lymphocyte-predominant breast cancer through modulation of NKG2D ligand and TNF cytokines on tumor cells.
Ataxia Telangiectasia
ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.
Ataxia Telangiectasia
ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence?
Ataxia Telangiectasia
ATM may be a protective factor in endometrial carcinogenesis with the progesterone pathway.
Ataxia Telangiectasia
ATM mediated-p53 signaling pathway forms a novel axis for senescence control.
Ataxia Telangiectasia
ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.
Ataxia Telangiectasia
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Ataxia Telangiectasia
ATM mediates repression of DNA end-degradation in an ATP-dependent manner.
Ataxia Telangiectasia
ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot.
Ataxia Telangiectasia
ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response.
Ataxia Telangiectasia
ATM mutations as an independent prognostic factor and potential biomarker for immune checkpoint therapy in endometrial cancer.
Ataxia Telangiectasia
ATM Mutations Benefit Bladder Cancer Patients Treated With Immune Checkpoint Inhibitors by Acting on the Tumor Immune Microenvironment.
Ataxia Telangiectasia
ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data.
Ataxia Telangiectasia
ATM mutations on distinct SNP and STR haplotypes in ataxia-telangiectasia patients of differing ethnicities reveal ancestral founder effects.
Ataxia Telangiectasia
ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.
Ataxia Telangiectasia
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
Ataxia Telangiectasia
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
Ataxia Telangiectasia
ATM Polymorphisms Are Associated With Risk of Radiation-Induced Pneumonitis.
Ataxia Telangiectasia
ATM Polymorphisms Predict Severe Radiation Pneumonitis in Patients With Non-Small Cell Lung Cancer Treated With Definitive Radiation Therapy.
Ataxia Telangiectasia
ATM prevents DSB formation by coordinating SSB repair and cell cycle progression.
Ataxia Telangiectasia
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Ataxia Telangiectasia
ATM Prevents Unattended DNA Double Strand Breaks on Site and in Generations to Come.
Ataxia Telangiectasia
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Ataxia Telangiectasia
ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis.
Ataxia Telangiectasia
ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease.
Ataxia Telangiectasia
ATM Protein Kinase: Old and New Implications in Neuronal Pathways and Brain Circuitry.
Ataxia Telangiectasia
ATM protein overexpression in prostate tumors: possible role in telomere maintenance.
Ataxia Telangiectasia
ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
Ataxia Telangiectasia
ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.
Ataxia Telangiectasia
ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.
Ataxia Telangiectasia
ATM regulates ATR chromatin loading in response to DNA double-strand breaks.
Ataxia Telangiectasia
ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication.
Ataxia Telangiectasia
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
Ataxia Telangiectasia
ATM regulates NF-?B-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment.
Ataxia Telangiectasia
ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance.
Ataxia Telangiectasia
ATM regulates the length of individual telomere tracts in Arabidopsis.
Ataxia Telangiectasia
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.
Ataxia Telangiectasia
ATM rs189037 (G?>?A) polymorphism increased the risk of cancer: an updated meta-analysis.
Ataxia Telangiectasia
ATM rs189037 (G > A) polymorphism and risk of lung cancer and head and neck cancer: A meta-analysis.
Ataxia Telangiectasia
ATM rs189037 significantly increases the risk of cancer in non-smokers rather than smokers: an updated meta-analysis.
Ataxia Telangiectasia
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
Ataxia Telangiectasia
ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells.
Ataxia Telangiectasia
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Ataxia Telangiectasia
ATM supports gammaherpesvirus replication by attenuating type I interferon pathway.
Ataxia Telangiectasia
ATM Suppresses Leaf Senescence Triggered by DNA Double-strand Break through Epigenetic Control of Senescence-Associated Genes in Arabidopsis.
Ataxia Telangiectasia
ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations.
Ataxia Telangiectasia
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.
Ataxia Telangiectasia
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.
Ataxia Telangiectasia
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Ataxia Telangiectasia
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
Ataxia Telangiectasia
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks.
Ataxia Telangiectasia
ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?
Ataxia Telangiectasia
ATM-associated signalling triggers the unfolded protein response and cell death in response to stress.
Ataxia Telangiectasia
ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress.
Ataxia Telangiectasia
ATM-Deficient Cancers Provide New Opportunities for Precision Oncology.
Ataxia Telangiectasia
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib.
Ataxia Telangiectasia
Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.
Ataxia Telangiectasia
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
Ataxia Telangiectasia
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins.
Ataxia Telangiectasia
ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.
Ataxia Telangiectasia
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.
Ataxia Telangiectasia
ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.
Ataxia Telangiectasia
ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome.
Ataxia Telangiectasia
ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia.
Ataxia Telangiectasia
ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response.
Ataxia Telangiectasia
ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.
Ataxia Telangiectasia
ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin.
Ataxia Telangiectasia
ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses.
Ataxia Telangiectasia
ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage.
Ataxia Telangiectasia
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Ataxia Telangiectasia
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Ataxia Telangiectasia
ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response.
Ataxia Telangiectasia
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.
Ataxia Telangiectasia
ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.
Ataxia Telangiectasia
ATM-mediated phosphorylation activates the tumor-suppressive function of B56?-PP2A.
Ataxia Telangiectasia
ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.
Ataxia Telangiectasia
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
Ataxia Telangiectasia
ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis.
Ataxia Telangiectasia
ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair.
Ataxia Telangiectasia
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.
Ataxia Telangiectasia
ATM-mediated transcriptional elevation of prion in response to copper-induced oxidative stress.
Ataxia Telangiectasia
ATM?JAK?PD?L1 signaling pathway inhibition decreases EMT and metastasis of androgen?independent prostate cancer.
Ataxia Telangiectasia
ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
Ataxia Telangiectasia
AtMMS21 regulates DNA damage response and homologous recombination repair in Arabidopsis.
Ataxia Telangiectasia
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.
Ataxia Telangiectasia
ATP synthase: an identified target gene of bantam in paired female Schistosoma japonicum.
Ataxia Telangiectasia
ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.
Ataxia Telangiectasia
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
Ataxia Telangiectasia
ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms.
Ataxia Telangiectasia
ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage.
Ataxia Telangiectasia
ATR regulates hexavalent chromium-induced S-phase checkpoint through phosphorylation of SMC1.
Ataxia Telangiectasia
ATR-Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine.
Ataxia Telangiectasia
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.
Ataxia Telangiectasia
ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells.
Ataxia Telangiectasia
ATR-mediated phosphorylation of DNA polymerase ? is needed for efficient recovery from UV damage.
Ataxia Telangiectasia
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Ataxia Telangiectasia
Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration.
Ataxia Telangiectasia
Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo.
Ataxia Telangiectasia
Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan.
Ataxia Telangiectasia
Autocrine regulation of ?-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors.
Ataxia Telangiectasia
Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells.
Ataxia Telangiectasia
Autophosphorylated residues involved in the regulation of human chk2 in vitro.
Ataxia Telangiectasia
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
Ataxia Telangiectasia
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Ataxia Telangiectasia
Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation.
Ataxia Telangiectasia
AZ32 Reverses ABCG2-Mediated Multidrug Resistance in Colorectal Cancer.
Ataxia Telangiectasia
B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection.
Ataxia Telangiectasia
Bacterial quorum-sensing signal IQS induces host cell apoptosis by targeting POT1-p53 signalling pathway.
Ataxia Telangiectasia
Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Ataxia Telangiectasia
Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes.
Ataxia Telangiectasia
Benzyl butyl phthalate (BBP) triggers the migration and invasion of hemangioma cells via upregulation of Zeb1.
Ataxia Telangiectasia
Beta Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes.
Ataxia Telangiectasia
Beta-Ecdysone Protects Mouse Osteoblasts from Glucocorticoid-Induced Apoptosis In Vitro.
Ataxia Telangiectasia
Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma.
Ataxia Telangiectasia
Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy.
Ataxia Telangiectasia
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism.
Ataxia Telangiectasia
Bifunctional DNA Alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea Activates the ATR-Chk1 Pathway Independently of the Mismatch Repair Pathway.
Ataxia Telangiectasia
Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.
Ataxia Telangiectasia
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
Ataxia Telangiectasia
BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients.
Ataxia Telangiectasia
Bisphenol A-Induced Ovotoxicity Involves DNA Damage Induction to Which the Ovary Mounts a Protective Response Indicated by Increased Expression of Proteins Involved in DNA Repair and Xenobiotic Biotransformation.
Ataxia Telangiectasia
Blm-s, a BH3-only protein enriched in postmitotic immature neurons, is transcriptionally upregulated by p53 during DNA damage.
Ataxia Telangiectasia
Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling.
Ataxia Telangiectasia
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Ataxia Telangiectasia
Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation.
Ataxia Telangiectasia
Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.
Ataxia Telangiectasia
Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice.
Ataxia Telangiectasia
Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1.
Ataxia Telangiectasia
Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation.
Ataxia Telangiectasia
Brain and induced pluripotent stem cell-derived neural stem cells as an in vitro model of neurodegeneration in ataxia-telangiectasia.
Ataxia Telangiectasia
Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study.
Ataxia Telangiectasia
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging.
Ataxia Telangiectasia
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis.
Ataxia Telangiectasia
Breaking the DNA damage response via serine/threonine kinase inhibitors to improve cancer treatment.
Ataxia Telangiectasia
Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.
Ataxia Telangiectasia
Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.
Ataxia Telangiectasia
Buried territories: heterochromatic response to DNA double-strand breaks.
Ataxia Telangiectasia
c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP.
Ataxia Telangiectasia
c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF.
Ataxia Telangiectasia
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance.
Ataxia Telangiectasia
Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity.
Ataxia Telangiectasia
Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe.
Ataxia Telangiectasia
Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.
Ataxia Telangiectasia
Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis.
Ataxia Telangiectasia
cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells.
Ataxia Telangiectasia
Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells.
Ataxia Telangiectasia
Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro.
Ataxia Telangiectasia
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.
Ataxia Telangiectasia
Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells.
Ataxia Telangiectasia
Cardioprotective Function of Green Rooibos (Aspalathus linearis) Extract Supplementation in Ex Vivo Ischemic Prediabetic Rat Hearts.
Ataxia Telangiectasia
Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE2 pathway in non-small cell lung cancer.
Ataxia Telangiectasia
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth
Ataxia Telangiectasia
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.
Ataxia Telangiectasia
CDK2 Is Required for the DNA Damage Response During Porcine Early Embryonic Development.
Ataxia Telangiectasia
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
Ataxia Telangiectasia
CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair.
Ataxia Telangiectasia
Cell cycle activation linked to neuronal cell death initiated by DNA damage.
Ataxia Telangiectasia
Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression.
Ataxia Telangiectasia
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.
Ataxia Telangiectasia
Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: analysis by flow cytometry.
Ataxia Telangiectasia
Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer.
Ataxia Telangiectasia
Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair.
Ataxia Telangiectasia
Cellular functions of the protein kinase ATM and their relevance to human disease.
Ataxia Telangiectasia
Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil.
Ataxia Telangiectasia
CENPO expression regulates gastric cancer cell proliferation and is associated with poor patient prognosis.
Ataxia Telangiectasia
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.
Ataxia Telangiectasia
Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study.
Ataxia Telangiectasia
Cervical malignant mixed mesonephric tumour: A case report with local recurrence after six-years and next-generation sequencing analysis with particular reference to the ataxia telangiectasia mutated gene.
Ataxia Telangiectasia
Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells.
Ataxia Telangiectasia
Challenges in implementing model-based phase I designs in a grant-funded clinical trials unit.
Ataxia Telangiectasia
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.
Ataxia Telangiectasia
Changes in splicing factor expression are associated with advancing age in man.
Ataxia Telangiectasia
Characterisation of ATM Mutations in Slavic Ataxia Telangiectasia Patients.
Ataxia Telangiectasia
Characterization of an NBS1 C-terminal peptide that can inhibit ataxia telangiectasia mutated (ATM)-mediated DNA damage responses and enhance radiosensitivity.
Ataxia Telangiectasia
Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double-Strand Break-Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein.
Ataxia Telangiectasia
Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability.
Ataxia Telangiectasia
Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression.
Ataxia Telangiectasia
Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer.
Ataxia Telangiectasia
Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism.
Ataxia Telangiectasia
Chemical inhibition of DNA repair kinases as a promising tool in oncology.
Ataxia Telangiectasia
Chemical screening identifies ATM as a target for alleviating senescence.
Ataxia Telangiectasia
Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines.
Ataxia Telangiectasia
Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction.
Ataxia Telangiectasia
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways.
Ataxia Telangiectasia
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Ataxia Telangiectasia
Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.
Ataxia Telangiectasia
CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.
Ataxia Telangiectasia
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Ataxia Telangiectasia
CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).
Ataxia Telangiectasia
Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling.
Ataxia Telangiectasia
Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells.
Ataxia Telangiectasia
Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation.
Ataxia Telangiectasia
Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells.
Ataxia Telangiectasia
Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition.
Ataxia Telangiectasia
Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest.
Ataxia Telangiectasia
Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability.
Ataxia Telangiectasia
Chronic hypoxia in Andeans; are there lessons for neurology at sea level?
Ataxia Telangiectasia
Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA deregulation.
Ataxia Telangiectasia
Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.
Ataxia Telangiectasia
Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation.
Ataxia Telangiectasia
Circadian proteins in the regulation of cell cycle and genotoxic stress responses.
Ataxia Telangiectasia
Circadian rhythm genes in cancer: insight into their functions and regulation involving noncoding RNAs.
Ataxia Telangiectasia
CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract.
Ataxia Telangiectasia
Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest.
Ataxia Telangiectasia
Cisplatinum and taxol induce different patterns of p53 phosphorylation.
Ataxia Telangiectasia
CLASS SWITCH RECOMBINATION PROCESS IN ATAXIA TELANGIECTASIA PATIENTS WITH ELEVATED SERUM LEVELS OF IgM.
Ataxia Telangiectasia
Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95.
Ataxia Telangiectasia
Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation.
Ataxia Telangiectasia
Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.
Ataxia Telangiectasia
Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Ataxia Telangiectasia
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK.
Ataxia Telangiectasia
Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth.
Ataxia Telangiectasia
Co-inhibition of Pol ? and ATR sensitizes cisplatin-resistant non-small cell lung cancer cells to cisplatin by impeding DNA damage repair.
Ataxia Telangiectasia
Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells.
Ataxia Telangiectasia
Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer.
Ataxia Telangiectasia
Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair.
Ataxia Telangiectasia
Colorectal Choriocarcinoma in a Patient with Probable Lynch Syndrome.
Ataxia Telangiectasia
Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma.
Ataxia Telangiectasia
Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.
Ataxia Telangiectasia
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells.
Ataxia Telangiectasia
Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells.
Ataxia Telangiectasia
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
Ataxia Telangiectasia
Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement.
Ataxia Telangiectasia
Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population.
Ataxia Telangiectasia
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Ataxia Telangiectasia
Comparative toxicological evaluation of nonylphenol and nonylphenol polyethoxylates using human keratinocytes.
Ataxia Telangiectasia
Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin.
Ataxia Telangiectasia
Compartmentalization of DNA Damage Response between Heterochromatin and Euchromatin Is Mediated by Distinct H2A Histone Variants.
Ataxia Telangiectasia
Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Ataxia Telangiectasia
Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Ataxia Telangiectasia
Complete Pathologic Response of Multiple Liver Metastases and Clinical Complete Response of Rectal Cancer in a Patient with Ataxia-Telangiectasia Mutated Gene Mutations After XELOXIRI Plus Bevacizumab: A Case Report.
Ataxia Telangiectasia
Complete sequencing of full-length canine ataxia telangiectasia mutated mRNA and characterization of its putative promoter.
Ataxia Telangiectasia
Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.
Ataxia Telangiectasia
Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.
Ataxia Telangiectasia
Concurrent TP53 and CDKN2A Gene Aberrations in Newly Diagnosed Mantle Cell Lymphoma Correlate with Chemoresistance and Call for Innovative Upfront Therapy.
Ataxia Telangiectasia
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.
Ataxia Telangiectasia
Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass.
Ataxia Telangiectasia
Confirmation that variants in TTI2 are responsible for autosomal recessive intellectual disability.
Ataxia Telangiectasia
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Ataxia Telangiectasia
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
Ataxia Telangiectasia
Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.
Ataxia Telangiectasia
Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.
Ataxia Telangiectasia
Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection.
Ataxia Telangiectasia
Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma.
Ataxia Telangiectasia
Cooperative Enhancement of Radiosensitivity After Combined Treatment of 17-(Allylamino)-17-Demethoxygeldanamycin and Celecoxib in Human Lung and Colon Cancer Cell Lines.
Ataxia Telangiectasia
Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages.
Ataxia Telangiectasia
Coordinate to guard: crosstalk of phosphorylation, sumoylation, and ubiquitylation in DNA damage response.
Ataxia Telangiectasia
Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair.
Ataxia Telangiectasia
Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides.
Ataxia Telangiectasia
Correction to Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
Ataxia Telangiectasia
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia.
Ataxia Telangiectasia
Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response.
Ataxia Telangiectasia
Cross talk between stimulated NF-kappaB and the tumor suppressor p53.
Ataxia Telangiectasia
Cross-species identification of in silico microsatellite biomarkers for genetic disease.
Ataxia Telangiectasia
Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations.
Ataxia Telangiectasia
Cryptic deletion involving the ATM locus at 11q22.3 approximately q23.1 in B-cell chronic lymphocytic leukemia and related disorders.
Ataxia Telangiectasia
CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response.
Ataxia Telangiectasia
CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair.
Ataxia Telangiectasia
Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner.
Ataxia Telangiectasia
Cutaneous Granulomatosis and Class Switching Defect as a Presenting Sign in Ataxia-Telangiectasia: First Case from the National Iranian Registry and Review of the Literature.
Ataxia Telangiectasia
Cutaneous granulomatosis and combined immunodeficiency revealing Ataxia-Telangiectasia: a case report.
Ataxia Telangiectasia
Cyclooxygenase?2?mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium?tritium fusion radiation.
Ataxia Telangiectasia
Cyto-/genotoxic effect of CdSe/ZnS quantum dots in human lung adenocarcinoma cells for potential photodynamic UV therapy applications.
Ataxia Telangiectasia
Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.
Ataxia Telangiectasia
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation.
Ataxia Telangiectasia
Cytosine arabinoside induces phosphorylation of histone H2AX in hippocampal neurons via a noncanonical pathway.
Ataxia Telangiectasia
Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.
Ataxia Telangiectasia
Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.
Ataxia Telangiectasia
Damage-induced phosphorylation of Sld3 is important to block late origin firing.
Ataxia Telangiectasia
Danthron Induces DNA Damage and Inhibits DNA Repair Gene Expressions in GBM 8401 Human Brain Glioblastoma Multiforms Cells.
Ataxia Telangiectasia
Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
Ataxia Telangiectasia
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
Ataxia Telangiectasia
Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish.
Ataxia Telangiectasia
Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Ataxia Telangiectasia
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.
Ataxia Telangiectasia
Decrease of Nibrin expression in chronic hypoxia is associated with hypoxia-induced chemoresistance in some brain tumour cells.
Ataxia Telangiectasia
Decreased activation of ataxia telangiectasia mutated (ATM) in monocytes?from patients with systemic sclerosis.
Ataxia Telangiectasia
Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease.
Ataxia Telangiectasia
Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB.
Ataxia Telangiectasia
Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment.
Ataxia Telangiectasia
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.
Ataxia Telangiectasia
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Ataxia Telangiectasia
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
Ataxia Telangiectasia
Defective p53 Response and Apoptosis Associated with an Ataxia-Telangiectasia-like Phenotype.
Ataxia Telangiectasia
Defective regulation of Ca2+/calmodulin-dependent protein kinase II in gamma-irradiated ataxia telangiectasia fibroblasts.
Ataxia Telangiectasia
Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.
Ataxia Telangiectasia
Deficiency in the response to DNA double-strand breaks in mouse early preimplantation embryos.
Ataxia Telangiectasia
Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction.
Ataxia Telangiectasia
Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis.
Ataxia Telangiectasia
Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet.
Ataxia Telangiectasia
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Ataxia Telangiectasia
Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals.
Ataxia Telangiectasia
Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.
Ataxia Telangiectasia
Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity.
Ataxia Telangiectasia
Deletion of the B-B' and C-C' regions of inverted terminal repeats reduces rAAV productivity but increases transgene expression.
Ataxia Telangiectasia
Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation.
Ataxia Telangiectasia
Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance.
Ataxia Telangiectasia
Deoxypodophyllotoxin induces G(2)/M cell cycle arrest and apoptosis in HeLa cells.
Ataxia Telangiectasia
Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.
Ataxia Telangiectasia
Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.
Ataxia Telangiectasia
Design and synthesis of pyrrolobenzodiazepine-gallic hybrid agents as p53-dependent and -independent apoptogenic signaling in melanoma cells.
Ataxia Telangiectasia
Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses.
Ataxia Telangiectasia
Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.
Ataxia Telangiectasia
Detecting ATM-dependent chromatin modification in DNA damage response.
Ataxia Telangiectasia
Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay.
Ataxia Telangiectasia
Detection of early abl kinase activation after ionizing radiation by using a Peptide biosensor.
Ataxia Telangiectasia
Determination of cell fate by c-Abl activation in the response to DNA damage.
Ataxia Telangiectasia
Development of a high-content high-throughput screening assay for the discovery of ATM signaling inhibitors.
Ataxia Telangiectasia
Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma.
Ataxia Telangiectasia
Dichlorvos-induced cell cycle arrest and DNA damage repair activation in primary rat microglial cells.
Ataxia Telangiectasia
Differences in the Response to DNA Double-Strand Breaks between Rod Photoreceptors of Rodents, Pigs, and Humans.
Ataxia Telangiectasia
Differential DNA damage responses in p53 proficient and deficient cells: cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53-deficient lung cancer cells.
Ataxia Telangiectasia
Differential Expression of Small Heat Shock Protein 27 (Hsp27) in Ataxia telangiectasia Brains.
Ataxia Telangiectasia
Differential gene expression profile of retinoblastoma compared to normal retina.
Ataxia Telangiectasia
Differential Gene Expression Profiles of PPP2R5C-siRNA-Treated Malignant T Cells.
Ataxia Telangiectasia
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.
Ataxia Telangiectasia
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Ataxia Telangiectasia
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
Ataxia Telangiectasia
Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.
Ataxia Telangiectasia
Differential responses to high- and low-dose ultraviolet-B stress in tobacco Bright Yellow-2 cells.
Ataxia Telangiectasia
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.
Ataxia Telangiectasia
Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation.
Ataxia Telangiectasia
Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo.
Ataxia Telangiectasia
DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.
Ataxia Telangiectasia
Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.
Ataxia Telangiectasia
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
Ataxia Telangiectasia
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
Ataxia Telangiectasia
Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents.
Ataxia Telangiectasia
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.
Ataxia Telangiectasia
Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions.
Ataxia Telangiectasia
Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.
Ataxia Telangiectasia
Distinct biological effects of low-dose radiation on normal and cancerous human lung cells are mediated by ATM signaling.
Ataxia Telangiectasia
Distinct cellular responses to replication stress leading to apoptosis or senescence.
Ataxia Telangiectasia
Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.
Ataxia Telangiectasia
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.
Ataxia Telangiectasia
Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.
Ataxia Telangiectasia
Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.
Ataxia Telangiectasia
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.
Ataxia Telangiectasia
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis.
Ataxia Telangiectasia
Diversity of ATM gene mutations detected in patients with ataxia-telangiectasia.
Ataxia Telangiectasia
Diversity of ATM gene variants: a population-based genome data analysis for precision medicine.
Ataxia Telangiectasia
DNA Damage Activates TGF-? Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor T?RII.
Ataxia Telangiectasia
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin.
Ataxia Telangiectasia
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.
Ataxia Telangiectasia
DNA damage as a marker of brain damage in individuals with history of concussions.
Ataxia Telangiectasia
DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds.
Ataxia Telangiectasia
DNA damage mediated s and g(2) checkpoints in human embryonal carcinoma cells.
Ataxia Telangiectasia
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity.
Ataxia Telangiectasia
DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer.
Ataxia Telangiectasia
DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity.
Ataxia Telangiectasia
DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes.
Ataxia Telangiectasia
DNA damage response is hijacked by human papillomaviruses to complete their life cycle.
Ataxia Telangiectasia
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Ataxia Telangiectasia
DNA Damage Response Signals Transduce Stress From Rheumatoid Arthritis Risk Factors Into T Cell Dysfunction.
Ataxia Telangiectasia
DNA Damage Response-Related Proteins in Gastric Cancer: ATM, Chk2 and p53 Expression and Their Prognostic Value.
Ataxia Telangiectasia
DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture.
Ataxia Telangiectasia
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.
Ataxia Telangiectasia
DNA damage signaling in response to double-strand breaks during mitosis.
Ataxia Telangiectasia
DNA damage signaling is activated during cancer progression in human colorectal carcinoma.
Ataxia Telangiectasia
DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria.
Ataxia Telangiectasia
DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide.
Ataxia Telangiectasia
DNA damage-dependent NF-?B activation: NEMO turns nuclear signaling inside out.
Ataxia Telangiectasia
DNA damage-induced activation of ATM and ATM-dependent signaling pathways.
Ataxia Telangiectasia
DNA damage-induced activation of ATM promotes ?-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells.
Ataxia Telangiectasia
DNA damage-induced activation of ATM promotes ?-TRCP-mediated Mdm2 ubiquitination and destruction.
Ataxia Telangiectasia
DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.
Ataxia Telangiectasia
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Ataxia Telangiectasia
DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair.
Ataxia Telangiectasia
DNA Damage-Induced Transcription of Transposable Elements and Long Non-coding RNAs in Arabidopsis Is Rare and ATM-Dependent.
Ataxia Telangiectasia
DNA Damage-Sensing Kinases Mediate the Mouse 2-Cell Embryo's Response to Genotoxic Stress.
Ataxia Telangiectasia
DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.
Ataxia Telangiectasia
DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.
Ataxia Telangiectasia
DNA repair gene deficiency does not predispose human bronchial epithelial cells to benzo(a)pyrene-induced cell transformation.
Ataxia Telangiectasia
DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas.
Ataxia Telangiectasia
DNA-dependent protein kinase and Ataxia Telangiectasia Mutated (ATM) promote cell survival in response to NK314, a topoisomerase II? inhibitor.
Ataxia Telangiectasia
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
Ataxia Telangiectasia
DNA-Dependent Protein Kinase Catalytic Subunit: The Sensor for DNA Double-Strand Breaks Structurally and Functionally Related to Ataxia Telangiectasia Mutated.
Ataxia Telangiectasia
DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70.
Ataxia Telangiectasia
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.
Ataxia Telangiectasia
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Ataxia Telangiectasia
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-??-IRF1-CIITA pathway.
Ataxia Telangiectasia
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
Ataxia Telangiectasia
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells.
Ataxia Telangiectasia
DNA-PK suppresses a p53-independent apoptotic response to DNA damage.
Ataxia Telangiectasia
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.
Ataxia Telangiectasia
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Ataxia Telangiectasia
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.
Ataxia Telangiectasia
DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
Ataxia Telangiectasia
DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly.
Ataxia Telangiectasia
DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.
Ataxia Telangiectasia
DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response.
Ataxia Telangiectasia
Does Ataxia Telangiectasia Mutated (ATM) protect testicular and germ cell DNA integrity by regulating the redox status?
Ataxia Telangiectasia
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
Ataxia Telangiectasia
Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation.
Ataxia Telangiectasia
Down-expression of poly(ADP-ribose) polymerase in p53-regulated pancreatic cancer cells.
Ataxia Telangiectasia
Down-regulation of ATM protein in HRS cells of nodular sclerosis Hodgkin's lymphoma in children occurs in the absence of ATM gene inactivation.
Ataxia Telangiectasia
Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells.
Ataxia Telangiectasia
Down-regulation of NOX2 activity in phagocytes mediated by ATM-kinase dependent phosphorylation.
Ataxia Telangiectasia
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
Ataxia Telangiectasia
Downregulation of ATM Gene and Protein Expression in Canine Mammary Tumors.
Ataxia Telangiectasia
Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance.
Ataxia Telangiectasia
Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.
Ataxia Telangiectasia
Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks.
Ataxia Telangiectasia
Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.
Ataxia Telangiectasia
DUETTE: a phase II randomized, multicenter study to investigate the efficacy and tolerability of a second maintenance treatment in patients with platinum-sensitive relapsed epithelial ovarian cancer, who have previously received poly(ADP-ribose) polymerase (PARP) inhibitor maintenance treatment.
Ataxia Telangiectasia
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest.
Ataxia Telangiectasia
Dynamic modeling of cellular response to DNA damage based on p53 stress response networks.
Ataxia Telangiectasia
Dynamic monitoring of oxidative DNA double-strand break and repair in cardiomyocytes.
Ataxia Telangiectasia
Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours.
Ataxia Telangiectasia
Early B-cell specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice.
Ataxia Telangiectasia
Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus.
Ataxia Telangiectasia
Early-stage apoptosis is associated with DNA-damage-independent ATM phosphorylation and chromatin decondensation in NIH3T3 fibroblasts.
Ataxia Telangiectasia
EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway.
Ataxia Telangiectasia
EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.
Ataxia Telangiectasia
Effect of ATM heterozygosity on heritable DNA damage in mice following paternal F0 germline irradiation.
Ataxia Telangiectasia
Effect of ATM on inflammatory response and autophagy in renal tubular epithelial cells in LPS-induced septic AKI.
Ataxia Telangiectasia
Effect of ATM-111 (G>A) Polymorphism on Cancer Risk: A Meta-Analysis.
Ataxia Telangiectasia
Effect of ATR Inhibition in RT Response of HPV-Negative and HPV-Positive Head and Neck Cancers.
Ataxia Telangiectasia
Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients.
Ataxia Telangiectasia
Effect of epigallocatechin-3-gallate (EGCG) on embryos inseminated with oxidative stress-induced DNA damage sperm.
Ataxia Telangiectasia
Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.
Ataxia Telangiectasia
Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study.
Ataxia Telangiectasia
Effect of specific activation of ?-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy.
Ataxia Telangiectasia
Effect of TERT and ATM on gene expression profiles in human fibroblasts.
Ataxia Telangiectasia
Effects of aflatoxin B1 on the cell cycle distribution of splenocytes in chickens.
Ataxia Telangiectasia
Effects of Ataxia Telangiectasia Mutated (ATM) Genotypes and Smoking Habits on Lung Cancer Risk in Taiwan.
Ataxia Telangiectasia
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.
Ataxia Telangiectasia
Effects of low and high LET radiations on bystander human lung fibroblast cell survival.
Ataxia Telangiectasia
Effects of low dose ionizing radiation on DNA damage-caused pathways by reverse-phase protein array and Bayesian networks.
Ataxia Telangiectasia
Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma.
Ataxia Telangiectasia
Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro.
Ataxia Telangiectasia
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Ataxia Telangiectasia
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.
Ataxia Telangiectasia
Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells.
Ataxia Telangiectasia
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA.
Ataxia Telangiectasia
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.
Ataxia Telangiectasia
Elevated Expression of Hepatoma Up-Regulated Protein Inhibits ?-Irradiation-Induced Apoptosis of Prostate Cancer Cells.
Ataxia Telangiectasia
Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Ataxia Telangiectasia
Emerging strategies to target cancer metabolism and improve radiation therapy outcomes.
Ataxia Telangiectasia
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Ataxia Telangiectasia
En Guard! The Interactions between Adenoviruses and the DNA Damage Response.
Ataxia Telangiectasia
Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response.
Ataxia Telangiectasia
Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.
Ataxia Telangiectasia
Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidative stress.
Ataxia Telangiectasia
Endothelin-1 and ?-melanocortin have redundant effects on global genome repair in UV-irradiated human melanocytes despite distinct signaling pathways.
Ataxia Telangiectasia
Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity.
Ataxia Telangiectasia
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.
Ataxia Telangiectasia
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells.
Ataxia Telangiectasia
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells.
Ataxia Telangiectasia
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
Ataxia Telangiectasia
Enhanced UV Resistance Role of Death Domain-Associated Protein in Human MDA-MB-231 Breast Cancer Cells by Regulation of G2 DNA Damage Checkpoint.
Ataxia Telangiectasia
Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines.
Ataxia Telangiectasia
Epidermal stem cells and cancer stem cells: insights into cancer and potential therapeutic strategies.
Ataxia Telangiectasia
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Ataxia Telangiectasia
Epigenetic Mechanisms of ATM Activation after Helicobacter pylori Infection.
Ataxia Telangiectasia
ER-Dependent Ca++-mediated Cytosolic ROS as an Effector for Induction of Mitochondrial Apoptotic and ATM-JNK Signal Pathways in Gallic Acid-treated Human Oral Cancer Cells.
Ataxia Telangiectasia
ERK kinases modulate the activation of PI3 kinase related kinases (PIKKs) in DNA damage response.
Ataxia Telangiectasia
Essential Role of Ubiquitin-Fold Modifier 1 Conjugation in DNA Damage Response.
Ataxia Telangiectasia
Establishing trusting partnerships for successful recruitment of American Indians to clinical trials.
Ataxia Telangiectasia
Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies.
Ataxia Telangiectasia
Evaluation of cytotoxicity and DNA damage response with analysis of intracellular ATM signaling pathways.
Ataxia Telangiectasia
Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer.
Ataxia Telangiectasia
Evaluation of the spatial distribution of gammaH2AX following ionizing radiation.
Ataxia Telangiectasia
Evasion of early cellular response mechanisms following low level radiation-induced DNA damage.
Ataxia Telangiectasia
Evidence for pathogenicity of variant ATM Val1729Leu in a family with ataxia telangiectasia.
Ataxia Telangiectasia
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.
Ataxia Telangiectasia
Evolutionary model of brain tumor circulating cells: Cellular galaxy.
Ataxia Telangiectasia
Excess growth hormone suppresses DNA damage repair in epithelial cells.
Ataxia Telangiectasia
Exploiting replicative stress in gynecological cancers as a therapeutic strategy.
Ataxia Telangiectasia
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Ataxia Telangiectasia
Exploring the Influence of Parameters on the p53 Response When Single-Stranded Breaks and Double-Stranded Breaks Coexist.
Ataxia Telangiectasia
Exploring the role of high-mobility group box 1 (HMGB1) protein in the pathogenesis of Huntington's disease.
Ataxia Telangiectasia
Exposure of the cytoplasm to low-dose X-rays modifies ataxia telangiectasia mutated-mediated DNA damage responses.
Ataxia Telangiectasia
Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer.
Ataxia Telangiectasia
Expression and maintenance of mitochondrial DNA: new insights into human disease pathology.
Ataxia Telangiectasia
Expression of HPV-induced DNA Damage Repair Factors Correlates With CIN Progression.
Ataxia Telangiectasia
Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression.
Ataxia Telangiectasia
Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3? in the striatum of rats treated with 3-nitropropionic acid.
Ataxia Telangiectasia
Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival.
Ataxia Telangiectasia
Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia.
Ataxia Telangiectasia
Extracellular matrix metalloproteinase inducer (CD147/BSG/EMMPRIN)-induced radioresistance in cervical cancer by regulating the percentage of the cells in the G2/m phase of the cell cycle and the repair of DNA Double-strand Breaks (DSBs).
Ataxia Telangiectasia
Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.
Ataxia Telangiectasia
EZH2 Loss Drives Resistance to Carboplatin and Paclitaxel in Serous Ovarian Cancers Expressing ATM.
Ataxia Telangiectasia
Familial lymphoid neoplasms in patients with mantle cell lymphoma Familial lymphoid neoplasms in patients with mantle cell lymphoma.
Ataxia Telangiectasia
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Ataxia Telangiectasia
Far-infrared irradiation inhibits breast cancer cell proliferation independently of DNA damage through increased nuclear Ca2+/calmodulin binding modulated-activation of checkpoint kinase 2.
Ataxia Telangiectasia
Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells.
Ataxia Telangiectasia
FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.
Ataxia Telangiectasia
Fibroblasts from Retinoblastoma Patients Show Radiosensitivity Linked to Abnormal Localization of the ATM Protein.
Ataxia Telangiectasia
First international workshop of the ATM and cancer risk group (4-5 December 2019).
Ataxia Telangiectasia
First-in-Human Trial of the Oral Ataxia Telangiectasia and Rad3-Related Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors.
Ataxia Telangiectasia
Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.
Ataxia Telangiectasia
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
Ataxia Telangiectasia
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Ataxia Telangiectasia
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Ataxia Telangiectasia
FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage.
Ataxia Telangiectasia
Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families.
Ataxia Telangiectasia
Fresh and ozonized black carbon promoted DNA damage and repair responses in A549 cells.
Ataxia Telangiectasia
Functional Activation of ATM by the Prostate Cancer Suppressor NKX3.1.
Ataxia Telangiectasia
Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses.
Ataxia Telangiectasia
Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk.
Ataxia Telangiectasia
Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
Ataxia Telangiectasia
Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways.
Ataxia Telangiectasia
Functional classification of ATM variants in ataxia-telangiectasia patients.
Ataxia Telangiectasia
Functional interaction between FOXO3a and ATM regulates DNA damage response.
Ataxia Telangiectasia
Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.
Ataxia Telangiectasia
Functional polymorphism rs189037 in the promoter region of ATM gene is associated with angiographically characterized coronary stenosis.
Ataxia Telangiectasia
Functional proteomic pattern identification under low dose ionizing radiation.
Ataxia Telangiectasia
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
Ataxia Telangiectasia
Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.
Ataxia Telangiectasia
Functions and regulation of Artemis: a goddess in the maintenance of genome integrity.
Ataxia Telangiectasia
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses.
Ataxia Telangiectasia
G2 arrest in response to topoisomerase II inhibitors: the role of p53.
Ataxia Telangiectasia
G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin.
Ataxia Telangiectasia
Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice.
Ataxia Telangiectasia
Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells.
Ataxia Telangiectasia
Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway.
Ataxia Telangiectasia
Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells.
Ataxia Telangiectasia
Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
Ataxia Telangiectasia
Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1.
Ataxia Telangiectasia
Gamma-radiation-induced phosphorylation of p53 on serine 15 is dose-dependent in MOLT-4 leukaemia cells.
Ataxia Telangiectasia
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated.
Ataxia Telangiectasia
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.
Ataxia Telangiectasia
Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX.
Ataxia Telangiectasia
Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing.
Ataxia Telangiectasia
Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells.
Ataxia Telangiectasia
Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.
Ataxia Telangiectasia
Genetic link between heme oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster.
Ataxia Telangiectasia
Genetic polymorphism contributes to 131I radiotherapy-induced toxicities in patients with differentiated thyroid cancer.
Ataxia Telangiectasia
Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk.
Ataxia Telangiectasia
Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.
Ataxia Telangiectasia
Genetic testing for hereditary prostate cancer: Current status and limitations.
Ataxia Telangiectasia
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Ataxia Telangiectasia
Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-?B/IKK pathway-induced apoptosis.
Ataxia Telangiectasia
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.
Ataxia Telangiectasia
Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells.
Ataxia Telangiectasia
Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.
Ataxia Telangiectasia
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Ataxia Telangiectasia
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Ataxia Telangiectasia
Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution.
Ataxia Telangiectasia
Genotype-phenotype correlations in ataxia telangiectasia patients with ATM c.3576G>A and c.8147T>C mutations.
Ataxia Telangiectasia
Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia.
Ataxia Telangiectasia
Germline genetic variants in men with prostate cancer and one or more additional cancers.
Ataxia Telangiectasia
Germline PALB2, ATM variants in a patient with breast and ovarian cancer at risk for familial cancer syndrome: Is there a role for risk-reducing salpingo-oophorectomy?
Ataxia Telangiectasia
Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers.
Ataxia Telangiectasia
Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.
Ataxia Telangiectasia
GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions.
Ataxia Telangiectasia
GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices.
Ataxia Telangiectasia
Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells.
Ataxia Telangiectasia
Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation.
Ataxia Telangiectasia
Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition.
Ataxia Telangiectasia
Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.
Ataxia Telangiectasia
H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions.
Ataxia Telangiectasia
H2AX gene does not have a modifier effect on ataxia-telangiectasia phenotype.
Ataxia Telangiectasia
H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase.
Ataxia Telangiectasia
H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation.
Ataxia Telangiectasia
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Ataxia Telangiectasia
Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation.
Ataxia Telangiectasia
Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways.
Ataxia Telangiectasia
Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction.
Ataxia Telangiectasia
HDMX folds the nascent p53 mRNA following activation by the ATM kinase.
Ataxia Telangiectasia
Health risks for ataxia-telangiectasia mutated heterozygotes: A systematic review, Meta-analysis and evidence-based guideline.
Ataxia Telangiectasia
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
Ataxia Telangiectasia
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.
Ataxia Telangiectasia
Hedamycin, a DNA alkylator, induces (gamma)H2AX and chromosome aberrations: involvement of phosphatidylinositol 3-kinase-related kinases and DNA replication fork movement.
Ataxia Telangiectasia
Helichrysetin Induces DNA Damage that Triggers JNK-Mediated Apoptosis in Ca Ski Cells.
Ataxia Telangiectasia
Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein.
Ataxia Telangiectasia
Hepatitis B virus X protein activates E3 ubiquitin ligase Siah-1 to control virus propagation via a negative feedback loop.
Ataxia Telangiectasia
Hepatitis B virus X protein activates the ATM-Chk2 pathway and delays cell cycle progression.
Ataxia Telangiectasia
Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.
Ataxia Telangiectasia
Hepatitis C virus core activates proteasomal activator 28? expression via upregulation of p53 levels to control virus propagation.
Ataxia Telangiectasia
Hepatitis C virus infection downregulates the ligands of the activating receptor NKG2D.
Ataxia Telangiectasia
Hepatitis C virus mediated inhibition of miR-181c activates ATM signaling and promotes hepatocyte growth.
Ataxia Telangiectasia
Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm.
Ataxia Telangiectasia
Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses.
Ataxia Telangiectasia
Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice.
Ataxia Telangiectasia
Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor.
Ataxia Telangiectasia
High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways.
Ataxia Telangiectasia
High mobility group protein-mediated transcription requires DNA damage marker ?-H2AX.
Ataxia Telangiectasia
High pATM is Associated With Poor Local Control in Supraglottic Cancer Treated With Radiotherapy.
Ataxia Telangiectasia
High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability.
Ataxia Telangiectasia
High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.
Ataxia Telangiectasia
Histone chaperones play crucial roles in maintenance of stem cell niche during plant root development.
Ataxia Telangiectasia
Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/p53 pathway.
Ataxia Telangiectasia
Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis?
Ataxia Telangiectasia
Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability.
Ataxia Telangiectasia
Histone H2AX phosphorylation independent of ATM after X-irradiation in mouse liver and kidney in situ.
Ataxia Telangiectasia
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.
Ataxia Telangiectasia
Histopathological features of breast cancer in carriers of ATM gene variants.
Ataxia Telangiectasia
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents.
Ataxia Telangiectasia
HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells.
Ataxia Telangiectasia
Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.
Ataxia Telangiectasia
Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.
Ataxia Telangiectasia
HOMOLOGOUS RECOMBINATIONAL REPAIR FACTORS ARE RECRUITED AND LOADED ONTO THE VIRAL DNA GENOME IN EPSTEIN-BARR VIRUS REPLICATION COMPARTMENTS.
Ataxia Telangiectasia
Homozygous pathogenic variant in BRAT1 associated with nonprogressive cerebellar ataxia.
Ataxia Telangiectasia
Host DNA damage response facilitates African swine fever virus infection.
Ataxia Telangiectasia
How adeno-associated virus Rep78 protein arrests cells completely in S phase.
Ataxia Telangiectasia
How Human Papillomavirus Replication and Immune Evasion Strategies Take Advantage of the Host DNA Damage Repair Machinery.
Ataxia Telangiectasia
HPV infection associated DNA damage correlated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China.
Ataxia Telangiectasia
hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.
Ataxia Telangiectasia
Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.
Ataxia Telangiectasia
HSV-1 Hijacks the Host DNA Damage Response in Corneal Epithelial Cells through ICP4-Mediated Activation of ATM.
Ataxia Telangiectasia
hTERT-immortalized cells useful for analyzing effects of low-dose-rate radiation on human cells.
Ataxia Telangiectasia
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection.
Ataxia Telangiectasia
Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability.
Ataxia Telangiectasia
Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response.
Ataxia Telangiectasia
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins.
Ataxia Telangiectasia
Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells.
Ataxia Telangiectasia
Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo.
Ataxia Telangiectasia
Human Kinase/Phosphatase-Wide RNAi Screening Identified Checkpoint Kinase 2 as a Cellular Factor Facilitating Japanese Encephalitis Virus Infection.
Ataxia Telangiectasia
Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.
Ataxia Telangiectasia
Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways.
Ataxia Telangiectasia
Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers.
Ataxia Telangiectasia
Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection.
Ataxia Telangiectasia
Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199.
Ataxia Telangiectasia
Human SMG-1 is Involved in Gemcitabine-Induced Primary microRNA-155/BIC Up-Regulation in Human Pancreatic Cancer PANC-1 Cells.
Ataxia Telangiectasia
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.
Ataxia Telangiectasia
Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.
Ataxia Telangiectasia
HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells.
Ataxia Telangiectasia
Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence.
Ataxia Telangiectasia
Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction.
Ataxia Telangiectasia
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
Ataxia Telangiectasia
Hypoxia promotes radioresistance of CD133-positive Hep-2 human laryngeal squamous carcinoma cells in vitro.
Ataxia Telangiectasia
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Ataxia Telangiectasia
Hypoxic preconditioning decreases nuclear factor ?B activity via Disrupted in Schizophrenia-1.
Ataxia Telangiectasia
Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library.
Ataxia Telangiectasia
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
Ataxia Telangiectasia
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease.
Ataxia Telangiectasia
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.
Ataxia Telangiectasia
Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
Ataxia Telangiectasia
Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents.
Ataxia Telangiectasia
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.
Ataxia Telangiectasia
Identification of aberrantly methylated differentially expressed genes in breast cancer by integrated bioinformatics analysis.
Ataxia Telangiectasia
Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression.
Ataxia Telangiectasia
Identification of ATM mutations in Korean siblings with ataxia-telangiectasia.
Ataxia Telangiectasia
Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.
Ataxia Telangiectasia
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Ataxia Telangiectasia
Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells.
Ataxia Telangiectasia
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.
Ataxia Telangiectasia
Identification of Lethal microRNAs Specific for Head and Neck Cancer.
Ataxia Telangiectasia
Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
Ataxia Telangiectasia
Identification of Three Small Molecules That Can Selectively Influence Cellular Manganese Levels in a Mouse Striatal Cell Model.
Ataxia Telangiectasia
Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells.
Ataxia Telangiectasia
Identification of Two Novel Mutations in the ATM Gene from Patients with Ataxia-Telangiectasia by Whole Exome Sequencing.
Ataxia Telangiectasia
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Ataxia Telangiectasia
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Ataxia Telangiectasia
IL-1? Inflammatory Cytokine-Induced TP63 Isoform ?NP63? Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells.
Ataxia Telangiectasia
Image-Based High Content Screening: Automating the Quantification Process for DNA Damage-Induced Foci.
Ataxia Telangiectasia
Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts.
Ataxia Telangiectasia
Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks.
Ataxia Telangiectasia
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
Ataxia Telangiectasia
Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated gene.
Ataxia Telangiectasia
Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis.
Ataxia Telangiectasia
Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis.
Ataxia Telangiectasia
Impaired DNA Repair Fidelity in a Breast Cancer Patient With Adverse Reactions to Radiotherapy.
Ataxia Telangiectasia
Impaired insulin-stimulated glucose transport in ATM-deficient mouse skeletal muscle.
Ataxia Telangiectasia
Impaired up-regulation of polo-like kinase 2 in B-cell chronic lymphocytic leukaemia lymphocytes resistant to fludarabine and 2-chlorodeoxyadenosine: a potential marker of defective damage response.
Ataxia Telangiectasia
Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis.
Ataxia Telangiectasia
Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer.
Ataxia Telangiectasia
Improving Radiation Response in Glioblastoma Using ECO/siRNA Nanoparticles Targeting DNA Damage Repair.
Ataxia Telangiectasia
In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma.
Ataxia Telangiectasia
In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.
Ataxia Telangiectasia
Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells.
Ataxia Telangiectasia
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia.
Ataxia Telangiectasia
Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.
Ataxia Telangiectasia
Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.
Ataxia Telangiectasia
Increased expression of CHK2 in human gastric carcinomas harboring p53 mutations.
Ataxia Telangiectasia
Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.
Ataxia Telangiectasia
Increased radiation toxicity with germline ATM variant of uncertain clinical significance.
Ataxia Telangiectasia
Increased Regeneration Following Stress-Induced Lung Injury in Bleomycin-Treated Chimeric Mice with CD44 Knockout Mesenchymal Cells.
Ataxia Telangiectasia
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.
Ataxia Telangiectasia
Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells.
Ataxia Telangiectasia
Increased transferrin receptor expression following 11q23 deletion as a mechanism of malignant progression in chronic lymphocytic leukemia.
Ataxia Telangiectasia
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Ataxia Telangiectasia
Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients.
Ataxia Telangiectasia
Individual Radiosensitivity Assessment of the Families of Ataxia-Telangiectasia Patients by G2-Checkpoint Abrogation.
Ataxia Telangiectasia
Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.
Ataxia Telangiectasia
Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells.
Ataxia Telangiectasia
Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.
Ataxia Telangiectasia
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".
Ataxia Telangiectasia
Induction of DNA Damage Signaling upon Rift Valley Fever Virus Infection Results in Cell Cycle Arrest and Increased Viral Replication.
Ataxia Telangiectasia
Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer.
Ataxia Telangiectasia
Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine.
Ataxia Telangiectasia
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
Ataxia Telangiectasia
Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function.
Ataxia Telangiectasia
Inflammation, a significant player of Ataxia-Telangiectasia pathogenesis?
Ataxia Telangiectasia
Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis.
Ataxia Telangiectasia
Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells.
Ataxia Telangiectasia
Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis.
Ataxia Telangiectasia
Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer.
Ataxia Telangiectasia
Inhibition of Ataxia-Telangiectasia Mutated by Antisense Oligonucleotide Nanoparticles Induces Radiosensitization of Head and Neck Squamous-Cell Carcinoma in Mice.
Ataxia Telangiectasia
Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons.
Ataxia Telangiectasia
Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining.
Ataxia Telangiectasia
Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors.
Ataxia Telangiectasia
Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.
Ataxia Telangiectasia
Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer.
Ataxia Telangiectasia
Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress.
Ataxia Telangiectasia
Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma.
Ataxia Telangiectasia
Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development.
Ataxia Telangiectasia
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Ataxia Telangiectasia
Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation.
Ataxia Telangiectasia
Inhibition of DNA?PK activity sensitizes A549 cells to X?ray irradiation by inducing the ATM?dependent DNA damage response.
Ataxia Telangiectasia
Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation.
Ataxia Telangiectasia
Inhibition of hsp90 compromises the DNA damage response to radiation.
Ataxia Telangiectasia
Inhibition of p21-activated kinase 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway.
Ataxia Telangiectasia
Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
Ataxia Telangiectasia
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Ataxia Telangiectasia
Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.
Ataxia Telangiectasia
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Ataxia Telangiectasia
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells.
Ataxia Telangiectasia
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.
Ataxia Telangiectasia
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
Ataxia Telangiectasia
Inhibitor of Apoptosis Proteins Determines Glioblastoma Stem-Like Cell Fate in an Oxygen-Dependent Manner.
Ataxia Telangiectasia
Inhibitory effect of alpha-lipoic acid on mitochondrial dysfunction and interleukin-8 expression in interleukin-1beta-stimulated ataxia teleangiectasia fibroblasts.
Ataxia Telangiectasia
Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
Ataxia Telangiectasia
Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.
Ataxia Telangiectasia
Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity.
Ataxia Telangiectasia
Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Ataxia Telangiectasia
Insulin-like growth factor-1 attenuates cisplatin-induced gammaH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer.
Ataxia Telangiectasia
Insulin-like growth factor-1 receptor knockdown enhances radiosensitivity via the HIF-1? pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells.
Ataxia Telangiectasia
INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells.
Ataxia Telangiectasia
Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.
Ataxia Telangiectasia
Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data.
Ataxia Telangiectasia
Integrated signaling in developing lymphocytes: the role of DNA damage responses.
Ataxia Telangiectasia
Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells.
Ataxia Telangiectasia
Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation.
Ataxia Telangiectasia
Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation.
Ataxia Telangiectasia
Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression.
Ataxia Telangiectasia
Interplay between ATM and ATR in the regulation of common fragile site stability.
Ataxia Telangiectasia
Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest.
Ataxia Telangiectasia
Interstitial deletion in 3q in a patient with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and microcephaly, mild mental retardation and growth delay: clinical report and review of the literature.
Ataxia Telangiectasia
Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice.
Ataxia Telangiectasia
Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation.
Ataxia Telangiectasia
Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation.
Ataxia Telangiectasia
Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition.
Ataxia Telangiectasia
Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells.
Ataxia Telangiectasia
Involvement of DNA-PK and ATM in radiation- and heat-induced DNA damage recognition and apoptotic cell death.
Ataxia Telangiectasia
Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation.
Ataxia Telangiectasia
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Ataxia Telangiectasia
Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells.
Ataxia Telangiectasia
Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma.
Ataxia Telangiectasia
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
Ataxia Telangiectasia
Ionizing radiation can induce GSK-3beta phosphorylation and NF-kappaB transcriptional transactivation in ATM-deficient fibroblasts.
Ataxia Telangiectasia
Ionizing Radiation deregulates the microRNA expression profile in differentiated thyroid cells.
Ataxia Telangiectasia
Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells.
Ataxia Telangiectasia
Ionizing radiation enhances double-strand-break repair in rapamycin-treated ataxia telangiectasia lymphoblasts.
Ataxia Telangiectasia
Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4(+) T cells.
Ataxia Telangiectasia
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Ataxia Telangiectasia
Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells.
Ataxia Telangiectasia
Ionizing radiation response of primary normal human lens epithelial cells.
Ataxia Telangiectasia
Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related.
Ataxia Telangiectasia
IRF1 Negatively Regulates Oncogenic KPNA2 Expression Under Growth Stimulation and Hypoxia in Lung Cancer Cells.
Ataxia Telangiectasia
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation.
Ataxia Telangiectasia
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Ataxia Telangiectasia
Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes.
Ataxia Telangiectasia
Isoliquiritigenin causes DNA damage and inhibits ATM expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma.
Ataxia Telangiectasia
Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair.
Ataxia Telangiectasia
Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias.
Ataxia Telangiectasia
IVS10-6T>G, an ancient ATM germline mutation linked with breast cancer.
Ataxia Telangiectasia
Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells.
Ataxia Telangiectasia
JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell.
Ataxia Telangiectasia
Kaposi's sarcoma-associated herpesvirus induces the ATM and H2AX DNA damage response early during de novo infection of primary endothelial cells, which play roles in latency establishment.
Ataxia Telangiectasia
KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells.
Ataxia Telangiectasia
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis.
Ataxia Telangiectasia
Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80.
Ataxia Telangiectasia
KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8.
Ataxia Telangiectasia
Knockdown of RNF2 enhances radiosensitivity of lung squamous cell carcinoma cells.
Ataxia Telangiectasia
L-carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells.
Ataxia Telangiectasia
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1.
Ataxia Telangiectasia
Lack of ATM induces structural and functional changes in the heart: Role in ?-adrenergic receptor-stimulated apoptosis.
Ataxia Telangiectasia
Lack of effect of RuvB-like proteins on DNA damage signaling activation.
Ataxia Telangiectasia
Lack of involvement of ataxia telangiectasia mutated (ATM) in regulation of nuclear factor-kappaB (NF-kappaB) in human diploid fibroblasts.
Ataxia Telangiectasia
Late-onset autosomal recessive cerebellar ataxia and neuropathy with a novel splicing mutation in the ATM gene.
Ataxia Telangiectasia
Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells.
Ataxia Telangiectasia
LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.
Ataxia Telangiectasia
Lethal neonatal rigidity and multifocal seizure syndrome with a new mutation in BRAT1.
Ataxia Telangiectasia
Lethal Neonatal Rigidity and Multifocal Seizure Syndrome--A Misnamed Disorder?
Ataxia Telangiectasia
Level of reactive oxygen species induced by p21(WAF(1)CIP(1)) is critical for the determination of cell fate.
Ataxia Telangiectasia
Linking ATM Promoter Methylation to Cell Cycle Protein Expression in Brain Tumor Patients: Cellular Molecular Triangle Correlation in ATM Territory.
Ataxia Telangiectasia
LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
Ataxia Telangiectasia
Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation.
Ataxia Telangiectasia
Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101.
Ataxia Telangiectasia
Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation.
Ataxia Telangiectasia
Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells.
Ataxia Telangiectasia
Loss of ATM positively regulates Rac1 activity and cellular migration through oxidative stress.
Ataxia Telangiectasia
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
Ataxia Telangiectasia
Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.
Ataxia Telangiectasia
Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism.
Ataxia Telangiectasia
Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis.
Ataxia Telangiectasia
Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium.
Ataxia Telangiectasia
Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.
Ataxia Telangiectasia
Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC.
Ataxia Telangiectasia
Low ATM expression and progression-free and overall survival in advanced gastric cancer patients treated with first-line XELOX chemotherapy.
Ataxia Telangiectasia
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.
Ataxia Telangiectasia
Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer.
Ataxia Telangiectasia
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.
Ataxia Telangiectasia
Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
Ataxia Telangiectasia
Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.
Ataxia Telangiectasia
Low prevalence and independent prognostic role of del(11q) in Chinese patients with chronic lymphocytic leukemia.
Ataxia Telangiectasia
Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
Ataxia Telangiectasia
Low-dose irradiation promotes proliferation of the human breast cancer MDA-MB-231 cells through accumulation of mutant P53.
Ataxia Telangiectasia
Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients.
Ataxia Telangiectasia
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.
Ataxia Telangiectasia
Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma.
Ataxia Telangiectasia
Lymphocyte development: integration of DNA damage response signaling.
Ataxia Telangiectasia
Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks.
Ataxia Telangiectasia
Maize ATR safeguards genome stability during kernel development to prevent early endosperm endocycle onset and cell death.
Ataxia Telangiectasia
Mammosphere cells from high-passage MCF7 cell line show variable loss of tumorigenicity and radioresistance.
Ataxia Telangiectasia
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Ataxia Telangiectasia
Management of Individuals With a Mutation in the Ataxia Telangiectasia Mutated Gene.
Ataxia Telangiectasia
Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.
Ataxia Telangiectasia
Mathematical Model of ATM Activation and Chromatin Relaxation by Ionizing Radiation.
Ataxia Telangiectasia
Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.
Ataxia Telangiectasia
MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.
Ataxia Telangiectasia
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
Measurement of DNA-Dependent Protein Kinase Phosphorylation Using Flow Cytometry Provides a Reliable Estimate of DNA Repair Capacity.
Ataxia Telangiectasia
Mechanisms of Ataxia Telangiectasia Mutated (ATM) Control in the DNA Damage Response to Oxidative Stress, Epigenetic Regulation, and Persistent Innate Immune Suppression Following Sepsis.
Ataxia Telangiectasia
Mechanisms of Non-canonical Activation of Ataxia Telangiectasia Mutated.
Ataxia Telangiectasia
Mechanisms Underlying the Suppression of Chromosome Rearrangements by Ataxia-Telangiectasia Mutated.
Ataxia Telangiectasia
Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.
Ataxia Telangiectasia
Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.
Ataxia Telangiectasia
Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF.
Ataxia Telangiectasia
MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Ataxia Telangiectasia
Melanoma cells express elevated levels of phosphorylated histone H2AX foci.
Ataxia Telangiectasia
Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner.
Ataxia Telangiectasia
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Radiation-Induced Lung Injury via miRNA-214-3p.
Ataxia Telangiectasia
Mesenchymal stromal cells are genetically stable under a hostile in vivo-like scenario as revealed by in vitro micronucleus test.
Ataxia Telangiectasia
Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy.
Ataxia Telangiectasia
Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.
Ataxia Telangiectasia
Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR.
Ataxia Telangiectasia
Metastasis-associated gene 1 (MTA1) enhances cisplatin resistance of malignant pleural mesothelioma by ATR-Chk1-mediated DNA repair.
Ataxia Telangiectasia
Metformin activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA damage-like response.
Ataxia Telangiectasia
Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.
Ataxia Telangiectasia
Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.
Ataxia Telangiectasia
Methylation of the ataxia telangiectasia mutated gene (ATM) promoter as a radiotherapy outcome biomarker in patients with hepatocellular carcinoma.
Ataxia Telangiectasia
Methylglyoxal-bis(guanylhydrazone), a polyamine analogue, sensitized ?-radiation-induced cell death in HL-60 leukemia cells Sensitizing effect of MGBG on ?-radiation-induced cell death.
Ataxia Telangiectasia
Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin.
Ataxia Telangiectasia
Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.
Ataxia Telangiectasia
MicroRNA Analysis of ATM-Deficient Cells Indicate PTEN and CCDN1 as Potential Biomarkers of Radiation Response.
Ataxia Telangiectasia
microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation.
Ataxia Telangiectasia
MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer.
Ataxia Telangiectasia
MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis.
Ataxia Telangiectasia
MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.
Ataxia Telangiectasia
MicroRNA-223 Enhances Radiation Sensitivity of U87MG Cells In Vitro and In Vivo by Targeting Ataxia Telangiectasia Mutated.
Ataxia Telangiectasia
MicroRNA-361-5p slows down gliomas development through regulating UBR5 to elevate ATMIN protein expression.
Ataxia Telangiectasia
Microwave hyperthermia promotes caspase?3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non?small cell lung cancer cells.
Ataxia Telangiectasia
MiR-100 regulates cell viability and apoptosis by targeting ATM in pediatric acute myeloid leukemia.
Ataxia Telangiectasia
miR-15b/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung.
Ataxia Telangiectasia
miR-181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM.
Ataxia Telangiectasia
miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.
Ataxia Telangiectasia
miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase.
Ataxia Telangiectasia
MiR-203 inhibits tumor invasion and metastasis in gastric cancer by ATM.
Ataxia Telangiectasia
miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.
Ataxia Telangiectasia
miR-26a attenuates cardiac apoptosis and fibrosis by targeting ataxia-telangiectasia mutated in myocardial infarction.
Ataxia Telangiectasia
MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated.
Ataxia Telangiectasia
miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary.
Ataxia Telangiectasia
miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation.
Ataxia Telangiectasia
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Ataxia Telangiectasia
Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement.
Ataxia Telangiectasia
Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells.
Ataxia Telangiectasia
Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species.
Ataxia Telangiectasia
Mitochondrial Dysfunctions Regulated Radioresistance through Mitochondria-to-Nucleus Retrograde Signaling Pathway of NF-?B/PI3K/AKT2/mTOR.
Ataxia Telangiectasia
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
Ataxia Telangiectasia
Mobile phone signal exposure triggers a hormesis-like effect in Atm(+/+) and Atm(-/-) mouse embryonic fibroblasts.
Ataxia Telangiectasia
Modeling ATM mutant proteins from missense changes confirms retained kinase activity.
Ataxia Telangiectasia
Modeling the role of p53 pulses in DNA damage- induced cell death decision.
Ataxia Telangiectasia
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Ataxia Telangiectasia
Modulation of cellular senescence in fibroblasts and dermal papillae cells in vitro.
Ataxia Telangiectasia
Modulation of chromatin conformation by the histone deacetylase inhibitor trichostatin A promotes the removal of radiation-induced lesions in ataxia telangiectasia cell lines.
Ataxia Telangiectasia
Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia.
Ataxia Telangiectasia
Modulation of DNA repair capacity by Antaxia-telangiectasia mutated gene polymorphisms among polycyclic aromatic hydrocarbons exposed workers.
Ataxia Telangiectasia
Modulation of hypersensitivity to oxidative DNA damage in ATM defective cells induced by potassium bromate by inhibition of the Poly (ADP-ribose) polymerase (PARP).
Ataxia Telangiectasia
Modulation of the DNA repair system and ATR-p53 mediated apoptosis is relevant for tributyltin-induced genotoxic effects in human hepatoma G2 cells.
Ataxia Telangiectasia
Molecular and Radiological Features of Microsatellite Stable Colorectal Cancer Cases With Dramatic Responses to Immunotherapy.
Ataxia Telangiectasia
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.
Ataxia Telangiectasia
Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.
Ataxia Telangiectasia
Molecular cloning and characterization of the catalytic domain of zebrafish homologue of the ataxia-telangiectasia mutated gene.
Ataxia Telangiectasia
Molecular integrity and global gene expression of breast and lung cancer stem cells under long-term storage and recovery.
Ataxia Telangiectasia
Molecular Linkage Between the Kinase ATM and NF-{kappa}B Signaling in Response to Genotoxic Stimuli.
Ataxia Telangiectasia
Molecular Regulation of DNA Damage-Induced Apoptosis in Neurons of Cerebral Cortex.
Ataxia Telangiectasia
Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53.
Ataxia Telangiectasia
Molecular Testing Identifies Determinants of Exceptional Response and Guides Precision Therapy in a Patient with Lethal, Treatment-emergent Neuroendocrine Prostate Cancer.
Ataxia Telangiectasia
Monitoring and signaling of radiation-induced damage in mammalian cells.
Ataxia Telangiectasia
Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities.
Ataxia Telangiectasia
Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype.
Ataxia Telangiectasia
Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family.
Ataxia Telangiectasia
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.
Ataxia Telangiectasia
Motor pathway degeneration in young ataxia telangiectasia patients: A diffusion tractography study.
Ataxia Telangiectasia
Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.
Ataxia Telangiectasia
MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.
Ataxia Telangiectasia
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
Ataxia Telangiectasia
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Ataxia Telangiectasia
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Ataxia Telangiectasia
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1?.
Ataxia Telangiectasia
MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation.
Ataxia Telangiectasia
Multi-drugs resistant acne rosacea in a child affected by Ataxia-Telangiectasia: successful treatment with Isotretinoin.
Ataxia Telangiectasia
Multi-omics analysis of pathological changes in the amygdala of rats subjected to chronic restraint stress.
Ataxia Telangiectasia
Multidisciplinary Management of Ataxia Telangiectasia: Current Perspectives.
Ataxia Telangiectasia
Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy.
Ataxia Telangiectasia
Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance.
Ataxia Telangiectasia
Multiparametric cerebellar imaging and clinical phenotype in childhood ataxia telangiectasia.
Ataxia Telangiectasia
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
Ataxia Telangiectasia
Multispectral imaging flow cytometry reveals distinct frequencies of ?-H2AX foci induction in DNA double strand break repair defective human cell lines.
Ataxia Telangiectasia
Multistage Vectored siRNA Targeting Ataxia-Telangiectasia Mutated for Breast Cancer Therapy.
Ataxia Telangiectasia
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
Ataxia Telangiectasia
Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma.
Ataxia Telangiectasia
Mutant Single Nucleotide Polymorphism rs189037 in Ataxia-Telangiectasia Mutated Gene Is Significantly Associated With Ventricular Wall Thickness and Human Lifespan.
Ataxia Telangiectasia
Mutation analysis of multiple pilomatricomas in a patient with myotonic dystrophy type 1 suggests a DM1-associated hypermutation phenotype.
Ataxia Telangiectasia
Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma.
Ataxia Telangiectasia
Mutation at intronic repeats of the ataxia-telangiectasia mutated (ATM) gene and ATM protein loss in primary gastric cancer with microsatellite instability.
Ataxia Telangiectasia
Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.
Ataxia Telangiectasia
Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53.
Ataxia Telangiectasia
Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma.
Ataxia Telangiectasia
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.
Ataxia Telangiectasia
Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers.
Ataxia Telangiectasia
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.
Ataxia Telangiectasia
Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma.
Ataxia Telangiectasia
Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.
Ataxia Telangiectasia
MutL homolog 1 contributes to temozolomide-induced autophagy via ataxia-telangiectasia mutated in glioma.
Ataxia Telangiectasia
Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.
Ataxia Telangiectasia
Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-?B pathways.
Ataxia Telangiectasia
Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C.
Ataxia Telangiectasia
MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii.
Ataxia Telangiectasia
N-Acetyl Cysteine as a Novel Polymethyl Methacrylate Resin Component: Protection against Cell Apoptosis and Genotoxicity.
Ataxia Telangiectasia
N-methyl-N'-nitro-N-nitrosoguanidine activates cell-cycle arrest through distinct mechanisms activated in a dose-dependent manner.
Ataxia Telangiectasia
NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.
Ataxia Telangiectasia
Nanotube-based colorimetric probe for ultrasensitive detection of ataxia telangiectasia mutated protein.
Ataxia Telangiectasia
Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes.
Ataxia Telangiectasia
NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity.
Ataxia Telangiectasia
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-? Feedforward Signaling.
Ataxia Telangiectasia
Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons.
Ataxia Telangiectasia
Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis.
Ataxia Telangiectasia
New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress.
Ataxia Telangiectasia
New tricks for an old fox: impact of TGF? on the DNA damage response and genomic stability.
Ataxia Telangiectasia
NF-?B Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress.
Ataxia Telangiectasia
NF-kappa B signaling pathway as a target for human tumor radiosensitization.
Ataxia Telangiectasia
NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin.
Ataxia Telangiectasia
Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53.
Ataxia Telangiectasia
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Ataxia Telangiectasia
NMR- and MD simulation-based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated.
Ataxia Telangiectasia
No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer.
Ataxia Telangiectasia
Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin.
Ataxia Telangiectasia
Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1.
Ataxia Telangiectasia
Non-BRCA1/2 Breast Cancer Susceptibility Genes: A New Frontier with Clinical Consequences for Plastic Surgeons.
Ataxia Telangiectasia
Non-Hodgkin B-cell Lymphoma of the Ovary in a Child with Ataxia-Telangiectasia.
Ataxia Telangiectasia
Non-homologous end joining in class switch recombination: the beginning of the end.
Ataxia Telangiectasia
Non-homologous end joining pathway is the major route of protection against 4?-hydroxywithanolide E-induced DNA damage in MCF-7 cells.
Ataxia Telangiectasia
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks.
Ataxia Telangiectasia
Non-thermal DNA damage of cancer cells using near-infrared irradiation.
Ataxia Telangiectasia
Noncanonical ATM Activation and Signaling in Response to Transcription-Blocking DNA Damage.
Ataxia Telangiectasia
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Ataxia Telangiectasia
Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.
Ataxia Telangiectasia
NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.
Ataxia Telangiectasia
Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway.
Ataxia Telangiectasia
Novel composite drug delivery system as a novel radio sensitizer for the local treatment of cervical carcinoma.
Ataxia Telangiectasia
Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.
Ataxia Telangiectasia
Novel insights into the pathophysiology of chemotherapy-induced damage to the ovary.
Ataxia Telangiectasia
Novel pathway of centrosome amplification that does not require DNA lesions.
Ataxia Telangiectasia
Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway.
Ataxia Telangiectasia
Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGF? and ATM pathways.
Ataxia Telangiectasia
Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling.
Ataxia Telangiectasia
NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.
Ataxia Telangiectasia
NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway.
Ataxia Telangiectasia
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.
Ataxia Telangiectasia
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Ataxia Telangiectasia
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.
Ataxia Telangiectasia
Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.
Ataxia Telangiectasia
Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
Ataxia Telangiectasia
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress.
Ataxia Telangiectasia
Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue array.
Ataxia Telangiectasia
Nucleolar protein nucleolin functions in replication stress-induced DNA damage responses.
Ataxia Telangiectasia
Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degeneration.
Ataxia Telangiectasia
Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.
Ataxia Telangiectasia
Obesity alters the ovarian DNA damage response and apoptotic proteins.
Ataxia Telangiectasia
Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial.
Ataxia Telangiectasia
Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response.
Ataxia Telangiectasia
Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma.
Ataxia Telangiectasia
On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response.
Ataxia Telangiectasia
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Ataxia Telangiectasia
Oncogenic events triggered by AID, the adverse effect of antibody diversification.
Ataxia Telangiectasia
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer.
Ataxia Telangiectasia
Oncogenic WIP1 phosphatase attenuates the DNA damage response and sensitizes p53 mutant Jurkat cells to apoptosis.
Ataxia Telangiectasia
One-step site-directed mutagenesis of ATM cDNA in large (20kb) plasmid constructs.
Ataxia Telangiectasia
Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health.
Ataxia Telangiectasia
Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.
Ataxia Telangiectasia
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Ataxia Telangiectasia
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.
Ataxia Telangiectasia
Orphan nuclear receptor SHP negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of STAT5 transactivation.
Ataxia Telangiectasia
Oscillatory dynamics of p53 genetic network induced by feedback loops and time delays.
Ataxia Telangiectasia
Osteolineage niche cells initiate hematopoietic stem cell mobilization.
Ataxia Telangiectasia
Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer.
Ataxia Telangiectasia
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.
Ataxia Telangiectasia
Overexpression of B-cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response.
Ataxia Telangiectasia
Overexpression of CDCA2 in Human Squamous Cell Carcinoma: Correlation with Prevention of G1 Phase Arrest and Apoptosis.
Ataxia Telangiectasia
Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.
Ataxia Telangiectasia
Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer.
Ataxia Telangiectasia
Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis.
Ataxia Telangiectasia
Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction.
Ataxia Telangiectasia
Oxidative stress disassembles the p38/NPM/PP2A complex, which leads to modulation of nucleophosmin-mediated signaling to DNA damage response.
Ataxia Telangiectasia
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
Ataxia Telangiectasia
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.
Ataxia Telangiectasia
Oxidative stress induces apoptosis via calpain- and caspase-3-mediated cleavage of ATM in pancreatic acinar cells.
Ataxia Telangiectasia
Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice.
Ataxia Telangiectasia
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.
Ataxia Telangiectasia
p27Kip1 Stabilization Is Essential for the Maintenance of Cell Cycle Arrest in Response to DNA Damage.
Ataxia Telangiectasia
p38? plays differential roles in hematopoietic stem cell activity dependent on aging contexts.
Ataxia Telangiectasia
P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance.
Ataxia Telangiectasia
p53 and ATM/ATR regulate 7,12-dimethylbenz[a]anthracene-induced immunosuppression.
Ataxia Telangiectasia
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks.
Ataxia Telangiectasia
p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.
Ataxia Telangiectasia
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.
Ataxia Telangiectasia
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.
Ataxia Telangiectasia
p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure.
Ataxia Telangiectasia
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.
Ataxia Telangiectasia
p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both Ataxia-Telangiectasia Mutated and Prkdc.
Ataxia Telangiectasia
p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.
Ataxia Telangiectasia
P65-mediated miR-590 inhibition modulates the chemoresistance of osteosarcoma to doxorubicin through targeting wild-type p53-induced phosphatase 1.
Ataxia Telangiectasia
PACS-2 mediates the ATM and NF-?B-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage.
Ataxia Telangiectasia
Papillary thyroid carcinoma in a 9-year-old girl with ataxia-telangiectasia.
Ataxia Telangiectasia
Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.
Ataxia Telangiectasia
PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness.
Ataxia Telangiectasia
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Ataxia Telangiectasia
Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.
Ataxia Telangiectasia
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated.
Ataxia Telangiectasia
Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways.
Ataxia Telangiectasia
Pathological neoangiogenesis depends on oxidative stress regulation by ATM.
Ataxia Telangiectasia
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
Ataxia Telangiectasia
Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways.
Ataxia Telangiectasia
Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Ataxia Telangiectasia
Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis.
Ataxia Telangiectasia
Persistence of DNA Double-Strand Breaks in Normal Human Cells Induced by Radiation-Induced Bystander Effect.
Ataxia Telangiectasia
Persistence of DNA double-strand breaks in normal human cells induced by radiation-induced bystander effect.
Ataxia Telangiectasia
Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-?B activation.
Ataxia Telangiectasia
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells.
Ataxia Telangiectasia
PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells.
Ataxia Telangiectasia
Pharmacologic manipulation of the ataxia-telangiectasia mutated gene product as an intervention in age-related disease.
Ataxia Telangiectasia
Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.
Ataxia Telangiectasia
Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.
Ataxia Telangiectasia
Pharmacological targets and mechanisms of calycosin against meningitis.
Ataxia Telangiectasia
Pharmacology of the ATM inhibitor AZD0156: potentiation of irradiation and olaparib responses pre-clinically.
Ataxia Telangiectasia
Phase I Study of Ceralasertib (AZD6738), a Novel DNA Damage Repair Agent, in Combination with Weekly Paclitaxel in Refractory Cancer.
Ataxia Telangiectasia
Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.
Ataxia Telangiectasia
Phenformin and ataxia-telangiectasia mutated inhibitors synergistically co-suppress liver cancer cell growth by damaging mitochondria.
Ataxia Telangiectasia
Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair.
Ataxia Telangiectasia
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.
Ataxia Telangiectasia
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
Ataxia Telangiectasia
Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.
Ataxia Telangiectasia
Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line.
Ataxia Telangiectasia
Phospho-?Np63?-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
Ataxia Telangiectasia
Phospho-?Np63?/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells.
Ataxia Telangiectasia
Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
Ataxia Telangiectasia
Phosphoglycerate mutase 1 (PGAM1) overexpression promotes radio- and chemoresistance in gliomas by activating the DNA damage response.
Ataxia Telangiectasia
Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.
Ataxia Telangiectasia
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.
Ataxia Telangiectasia
Phosphorylated p63 induces transcription of regulatory particle non ATP-ase subunit 13 and nitric oxide synthase-2 protein degradation.
Ataxia Telangiectasia
Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function.
Ataxia Telangiectasia
Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
Ataxia Telangiectasia
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Ataxia Telangiectasia
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Ataxia Telangiectasia
Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.
Ataxia Telangiectasia
Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.
Ataxia Telangiectasia
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage.
Ataxia Telangiectasia
Phosphorylation of Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A by Ataxia Telangiectasia Mutated and Rad3-Related-Dependent Checkpoint Pathway Promotes Cell Survival in Response to UV Irradiation.
Ataxia Telangiectasia
Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway.
Ataxia Telangiectasia
Phosphorylation of p53 protein in A549 human pulmonary epithelial cells exposed to asbestos fibers.
Ataxia Telangiectasia
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
Ataxia Telangiectasia
Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis.
Ataxia Telangiectasia
Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.
Ataxia Telangiectasia
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Ataxia Telangiectasia
Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation.
Ataxia Telangiectasia
PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.
Ataxia Telangiectasia
Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation.
Ataxia Telangiectasia
Plant ?H2AX foci are required for proper DNA DSB repair responses and colocalize with E2F factors.
Ataxia Telangiectasia
PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening.
Ataxia Telangiectasia
Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase.
Ataxia Telangiectasia
Poly(ADP-ribosyl)ation affects stabilization of Che-1 protein in response to DNA damage.
Ataxia Telangiectasia
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.
Ataxia Telangiectasia
Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells.
Ataxia Telangiectasia
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Ataxia Telangiectasia
Polymorphism rs1801516 (G?>?A) in the ATM gene is not associated with overall cancer risk: an updated meta-analysis.
Ataxia Telangiectasia
Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study.
Ataxia Telangiectasia
Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types.
Ataxia Telangiectasia
Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts.
Ataxia Telangiectasia
Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia.
Ataxia Telangiectasia
Post-Translational Regulation of the RSF1 Chromatin Remodeler under DNA Damage.
Ataxia Telangiectasia
Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes.
Ataxia Telangiectasia
Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma.
Ataxia Telangiectasia
Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells.
Ataxia Telangiectasia
Potential role of ATM in hepatocyte endocytosis of ApoE-deficient, ApoB48-containing lipoprotein in ApoE-deficient mice.
Ataxia Telangiectasia
Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.
Ataxia Telangiectasia
PP2A Regulates Phosphorylation-Dependent Isomerization of Cytoplasmic and Mitochondrial-Associated ATR by Pin1 in DNA Damage Responses.
Ataxia Telangiectasia
PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
Ataxia Telangiectasia
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase.
Ataxia Telangiectasia
Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers.
Ataxia Telangiectasia
Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019.
Ataxia Telangiectasia
Predictive and Prognostic Value of DNA Damage Response Associated Kinases in Solid Tumors.
Ataxia Telangiectasia
Pretreatment of Small-for-Size Grafts In Vivo by ? -Aminobutyric Acid Receptor Regulation against Oxidative Stress-Induced Injury in Rat Split Orthotopic Liver Transplantation.
Ataxia Telangiectasia
Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells.
Ataxia Telangiectasia
Prevalence of ATM Sequence Variants in Northern Plains American Indian Cancer Patients.
Ataxia Telangiectasia
Prevention of thymic lymphoma development in Atm-/- mice by dexamethasone.
Ataxia Telangiectasia
Primary immunodeficiency syndromes associated with defective DNA double-strand break repair.
Ataxia Telangiectasia
Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts.
Ataxia Telangiectasia
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
Ataxia Telangiectasia
Prognostic relevance of ATM protein in uveal melanoma and its association with clinicopathological factors.
Ataxia Telangiectasia
Prognostic relevance of DNA damage and repair biomarkers in elderly patients with hormone-receptor-positive breast cancer treated with neoadjuvant hormone therapy: evidence from the real-world setting.
Ataxia Telangiectasia
Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer.
Ataxia Telangiectasia
Prognostic significance of ATM and cyclin B1 in pancreatic neuroendocrine tumor.
Ataxia Telangiectasia
Prognostic significance of G2/M arrest signaling pathway proteins in advanced non-small cell lung cancer patients.
Ataxia Telangiectasia
Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma.
Ataxia Telangiectasia
Programmed cell death may act as a surveillance mechanism to safeguard male gametophyte development in Arabidopsis.
Ataxia Telangiectasia
Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells.
Ataxia Telangiectasia
Programmed phosphorylation of histone H2AX precedes a phase of DNA double-strand break-independent synapsis in mouse meiosis.
Ataxia Telangiectasia
Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response.
Ataxia Telangiectasia
Promoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast Cancer
Ataxia Telangiectasia
Promotion of DNA repair by nuclear IKK? phosphorylation of ATM in response to genotoxic stimuli.
Ataxia Telangiectasia
Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of life thread.
Ataxia Telangiectasia
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Ataxia Telangiectasia
Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.
Ataxia Telangiectasia
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.
Ataxia Telangiectasia
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Ataxia Telangiectasia
Protective effects of ginsenoside Rg2 and astaxanthin mixture against UVB-induced DNA damage.
Ataxia Telangiectasia
Protective effects of Korean red ginseng against radiation-induced apoptosis in human HaCaT keratinocytes.
Ataxia Telangiectasia
Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation.
Ataxia Telangiectasia
Protective mechanism of morin against ultraviolet B-induced cellular senescence in human keratinocyte stem cells.
Ataxia Telangiectasia
Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
Ataxia Telangiectasia
Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs.
Ataxia Telangiectasia
Protein phosphatase 1? is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage.
Ataxia Telangiectasia
Protein Phosphatase 2A Antagonizes ATM and ATR in a Cdk2- and Cdc7-Independent DNA Damage Checkpoint.
Ataxia Telangiectasia
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.
Ataxia Telangiectasia
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination.
Ataxia Telangiectasia
Proteome-wide Detection and Quantitative Analysis of Irreversible Cysteine Oxidation Using Long Column UPLC-pSRM.
Ataxia Telangiectasia
Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity.
Ataxia Telangiectasia
Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling.
Ataxia Telangiectasia
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
Ataxia Telangiectasia
Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner.
Ataxia Telangiectasia
PTEN enhances G2/M arrest in etoposide-treated MCF?7 cells through activation of the ATM pathway.
Ataxia Telangiectasia
PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.
Ataxia Telangiectasia
PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer.
Ataxia Telangiectasia
Punicalagin from pomegranate promotes human papillary thyroid carcinoma BCPAP cell death by triggering ATM-mediated DNA damage response.
Ataxia Telangiectasia
Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1.
Ataxia Telangiectasia
Purkinje Cell Degeneration in pcd Mice Reveals Large Scale Chromatin Reorganization and Gene Silencing Linked to Defective DNA Repair.
Ataxia Telangiectasia
Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.
Ataxia Telangiectasia
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ataxia Telangiectasia
Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation.
Ataxia Telangiectasia
Quantitative and Dynamic Imaging of ATM Kinase Activity by Bioluminescence Imaging.
Ataxia Telangiectasia
Quantitative Mass Spectrometry by Isotope Dilution and Multiple Reaction Monitoring (MRM).
Ataxia Telangiectasia
Quantitative mRNA expression analysis of selected genes in patients with early-stage hypothyroidism induced by treatment with iodine-131.
Ataxia Telangiectasia
Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response.
Ataxia Telangiectasia
Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.
Ataxia Telangiectasia
r-Tocotrienol inhibits cell proliferation of human gastric cancer by regulating nuclear factor-kB activity.
Ataxia Telangiectasia
RAC1 GTPase plays an important role in ?-irradiation induced G2/M checkpoint activation.
Ataxia Telangiectasia
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
Ataxia Telangiectasia
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.
Ataxia Telangiectasia
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
Ataxia Telangiectasia
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.
Ataxia Telangiectasia
Radiation-induced DNA damage and repair effects on 3D genome organization.
Ataxia Telangiectasia
Radiation-Induced DNA Damage in Operators Performing Endovascular Aortic Repair.
Ataxia Telangiectasia
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.
Ataxia Telangiectasia
Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors.
Ataxia Telangiectasia
Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.
Ataxia Telangiectasia
Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer.
Ataxia Telangiectasia
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1?.
Ataxia Telangiectasia
Radiotherapy induces cell cycle arrest and cell apoptosis in nasopharyngeal carcinoma via the ATM and Smad pathways.
Ataxia Telangiectasia
Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-?B activation.
Ataxia Telangiectasia
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
Ataxia Telangiectasia
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.
Ataxia Telangiectasia
Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer.
Ataxia Telangiectasia
RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205.
Ataxia Telangiectasia
Rapid and efficient ATM mutation detection by fluorescent chemical cleavage of mismatch: identification of four novel mutations.
Ataxia Telangiectasia
Rapid and Progressive Pulmonary Fibrosis in 2 Families with DNA Repair Deficiencies of Undetermined Etiology.
Ataxia Telangiectasia
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Ataxia Telangiectasia
Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Ataxia Telangiectasia
Ras induces chromosome instability and abrogation of the DNA damage response.
Ataxia Telangiectasia
Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor.
Ataxia Telangiectasia
Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen.
Ataxia Telangiectasia
Reactive oxygen species abrogate the anticarcinogenic effect of eicosapentaenoic acid in Atm-deficient mice.
Ataxia Telangiectasia
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.
Ataxia Telangiectasia
Recent advances in the study of immunodeficiency and DNA damage response.
Ataxia Telangiectasia
Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications.
Ataxia Telangiectasia
Recently emerging signaling landscape of ataxia-telangiectasia mutated (ATM) kinase.
Ataxia Telangiectasia
Receptor Tyrosine Kinase EphA5 is a Functional Molecular Target in Human Lung Cancer.
Ataxia Telangiectasia
Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance.
Ataxia Telangiectasia
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Ataxia Telangiectasia
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.
Ataxia Telangiectasia
Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.
Ataxia Telangiectasia
Redox homeostasis: the linchpin in stem cell self-renewal and differentiation.
Ataxia Telangiectasia
Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance.
Ataxia Telangiectasia
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Ataxia Telangiectasia
Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein.
Ataxia Telangiectasia
Redundant and nonredundant functions of ATM and H2AX in ?? T-lineage lymphocytes.
Ataxia Telangiectasia
Regulation and localization of the Bloom syndrome protein in response to DNA damage.
Ataxia Telangiectasia
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Ataxia Telangiectasia
Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1.
Ataxia Telangiectasia
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
Ataxia Telangiectasia
Regulation of DNA Damage Response by Estrogen Receptor ?-Mediated Inhibition of Breast Cancer Associated Gene 2.
Ataxia Telangiectasia
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.
Ataxia Telangiectasia
Regulation of human pol? by ATM-mediated phosphorylation during non-homologous end joining.
Ataxia Telangiectasia
Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin.
Ataxia Telangiectasia
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling.
Ataxia Telangiectasia
Regulation of oxidative stress responses by ataxia-telangiectasia mutated is required for T cell proliferation.
Ataxia Telangiectasia
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.
Ataxia Telangiectasia
Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.
Ataxia Telangiectasia
Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.
Ataxia Telangiectasia
Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1.
Ataxia Telangiectasia
Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis.
Ataxia Telangiectasia
Remarkable response to a novel ATR inhibitor in a patient with poorly differentiated neuroendocrine carcinoma.
Ataxia Telangiectasia
Repair of Chromosomal RAG-Mediated DNA Breaks by Mutant RAG Proteins Lacking Phosphatidylinositol 3-Like Kinase Consensus Phosphorylation Sites.
Ataxia Telangiectasia
Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
Ataxia Telangiectasia
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.
Ataxia Telangiectasia
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Ataxia Telangiectasia
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Ataxia Telangiectasia
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Ataxia Telangiectasia
Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.
Ataxia Telangiectasia
Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype.
Ataxia Telangiectasia
Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site.
Ataxia Telangiectasia
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
Ataxia Telangiectasia
Resveratrol activates DNA damage response through inhibition of polo-like kinase 1 (PLK1) in natural killer/T cell lymphoma.
Ataxia Telangiectasia
Resveratrol ameliorates high-fat diet-induced insulin resistance and fatty acid oxidation via ATM-AMPK axis in skeletal muscle.
Ataxia Telangiectasia
Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces G?/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells.
Ataxia Telangiectasia
Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis.
Ataxia Telangiectasia
Retinoic Acid-related Orphan Receptor-? Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema.
Ataxia Telangiectasia
Revealing determinants of two-phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model.
Ataxia Telangiectasia
Revisiting p53 for cancer-specific chemo- and radiotherapy: Ten years after.
Ataxia Telangiectasia
Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.
Ataxia Telangiectasia
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Ataxia Telangiectasia
Riluzole Enhances the Response of Human Nasopharyngeal Carcinoma Cells to Ionizing Radiation via ATM/P53 Signalling Pathway.
Ataxia Telangiectasia
Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us.
Ataxia Telangiectasia
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells.
Ataxia Telangiectasia
RNF8 plays an important role in the radioresistance of human nasopharyngeal cancer cells in vitro.
Ataxia Telangiectasia
RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.
Ataxia Telangiectasia
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression.
Ataxia Telangiectasia
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.
Ataxia Telangiectasia
Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus.
Ataxia Telangiectasia
Role of ataxia-telangiectasia mutated (ATM) in porcine oocyte in vitro maturation.
Ataxia Telangiectasia
Role of ataxia-telangiectasia mutated in hydrogen peroxide preconditioning against oxidative stress in Neuro-2a cells.
Ataxia Telangiectasia
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
Ataxia Telangiectasia
Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death.
Ataxia Telangiectasia
Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia.
Ataxia Telangiectasia
Role of DNA damage in the progress of chronic tubule?interstitial injury.
Ataxia Telangiectasia
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review.
Ataxia Telangiectasia
Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53.
Ataxia Telangiectasia
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.
Ataxia Telangiectasia
Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus.
Ataxia Telangiectasia
Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.
Ataxia Telangiectasia
Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.
Ataxia Telangiectasia
Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases.
Ataxia Telangiectasia
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Ataxia Telangiectasia
Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair.
Ataxia Telangiectasia
Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection.
Ataxia Telangiectasia
Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response.
Ataxia Telangiectasia
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis.
Ataxia Telangiectasia
Rotavirus activates a noncanonical ATM-Chk2 branch of DNA damage response during infection to positively regulate viroplasm dynamics.
Ataxia Telangiectasia
Rotundic acid enhances the impact of radiological toxicity on MCF-7 cells through the ATM/p53 pathway.
Ataxia Telangiectasia
Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest.
Ataxia Telangiectasia
RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.
Ataxia Telangiectasia
RUG3 is a negative regulator of plant responses to ABA in Arabidopsis thaliana.
Ataxia Telangiectasia
S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells.
Ataxia Telangiectasia
SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in Arabidopsis.
Ataxia Telangiectasia
Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.
Ataxia Telangiectasia
Screening of gene mutations associated with bone metastasis in nonsmall cell lung cancer.
Ataxia Telangiectasia
Section 1. Antibiotics and Chemotherapeutics Apigenin induces DNA damage through the PKC?-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.
Ataxia Telangiectasia
Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection.
Ataxia Telangiectasia
Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage.
Ataxia Telangiectasia
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine.
Ataxia Telangiectasia
Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development.
Ataxia Telangiectasia
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
Ataxia Telangiectasia
Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.
Ataxia Telangiectasia
Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin.
Ataxia Telangiectasia
Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase.
Ataxia Telangiectasia
Ser-Gln sites of SOG1 are rapidly hyperphosphorylated in response to DNA double-strand breaks.
Ataxia Telangiectasia
Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.
Ataxia Telangiectasia
Severe Late Toxicity After Adjuvant Breast Radiotherapy in a Patient with a Germline Ataxia Telangiectasia Mutated Gene: Future Treatment Decisions.
Ataxia Telangiectasia
Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells.
Ataxia Telangiectasia
Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous ATM mutation.
Ataxia Telangiectasia
Sharpening the ends for repair: mechanisms and regulation of DNA resection.
Ataxia Telangiectasia
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
Ataxia Telangiectasia
SHP-1 overexpression increases the radioresistance of NPC cells by enhancing DSB repair, increasing S phase arrest and decreasing cell apoptosis.
Ataxia Telangiectasia
Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells.
Ataxia Telangiectasia
Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response.
Ataxia Telangiectasia
Significance of ATM Gene Polymorphisms in Chronic Myeloid Leukemia - a Case Control Study from India.
Ataxia Telangiectasia
Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation.
Ataxia Telangiectasia
Silencing of ataxia-telangiectasia mutated by siRNA enhances the in vitro and in vivo radiosensitivity of glioma.
Ataxia Telangiectasia
Silencing of ATM expression by siRNA technique contributes to glioma stem cell radiosensitivity in vitro and in vivo.
Ataxia Telangiectasia
Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells.
Ataxia Telangiectasia
Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.
Ataxia Telangiectasia
Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.
Ataxia Telangiectasia
Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks.
Ataxia Telangiectasia
Single nucleotide polymorphism in ATM gene, cooking oil fumes and lung adenocarcinoma susceptibility in Chinese female non-smokers: a case-control study.
Ataxia Telangiectasia
Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma.
Ataxia Telangiectasia
Single-nucleotide polymorphisms of TGF?1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China.
Ataxia Telangiectasia
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
Ataxia Telangiectasia
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
Ataxia Telangiectasia
SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.
Ataxia Telangiectasia
SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair.
Ataxia Telangiectasia
SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress.
Ataxia Telangiectasia
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
Ataxia Telangiectasia
Six Novel ATM Gene Variants in Sri Lankan Patients with Ataxia Telangiectasia.
Ataxia Telangiectasia
SLC22A1 And ATM Genes Polymorphisms Are Associated With The Risk Of Type 2 Diabetes Mellitus In Western Saudi Arabia: A Case-Control Study.
Ataxia Telangiectasia
Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells.
Ataxia Telangiectasia
SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.
Ataxia Telangiectasia
Sodium glycididazole enhances the radiosensitivity of laryngeal cancer cells through downregulation of ATM signaling pathway.
Ataxia Telangiectasia
Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.
Ataxia Telangiectasia
Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.
Ataxia Telangiectasia
Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage.
Ataxia Telangiectasia
Soy-derived isoflavones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo.
Ataxia Telangiectasia
Sp1 Facilitates DNA Double-Strand Break Repair through a Nontranscriptional Mechanism.
Ataxia Telangiectasia
Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer.
Ataxia Telangiectasia
Speckle-type POZ protein, SPOP, is involved in the DNA damage response.
Ataxia Telangiectasia
Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.
Ataxia Telangiectasia
Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans.
Ataxia Telangiectasia
Squalene Inhibits ATM-Dependent Signaling in ?IR-Induced DNA Damage Response through Induction of Wip1 Phosphatase.
Ataxia Telangiectasia
Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.
Ataxia Telangiectasia
Statistical Analysis of ATM-Dependent Signaling in Quantitative Mass Spectrometry Phosphoproteomics.
Ataxia Telangiectasia
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells.
Ataxia Telangiectasia
STING (or SRC) Like an ICB: Priming the Immune Response in Pancreatic Cancer.
Ataxia Telangiectasia
Strain background determines lymphoma incidence in atm knockout mice.
Ataxia Telangiectasia
Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia.
Ataxia Telangiectasia
Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells.
Ataxia Telangiectasia
Stress granules inhibit apoptosis by reducing reactive oxygen species production.
Ataxia Telangiectasia
Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp.
Ataxia Telangiectasia
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response.
Ataxia Telangiectasia
Structural basis for multifunctional roles of human Ints3 C-terminal domain.
Ataxia Telangiectasia
Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18.
Ataxia Telangiectasia
Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS).
Ataxia Telangiectasia
Substrate specificities and identification of putative substrates of ATM kinase family members.
Ataxia Telangiectasia
Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells.
Ataxia Telangiectasia
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.
Ataxia Telangiectasia
Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation.
Ataxia Telangiectasia
Suppression of the radiation-sensitive phenotype of hamster irs1 and irs2 strains selected for resistance to 3-aminobenzamide.
Ataxia Telangiectasia
Survival and Functional Immune Reconstitution After Haploidentical Stem Cell Transplantation in Atm-Deficient Mice.
Ataxia Telangiectasia
Susceptibility of ATM-deficient pancreatic cancer cells to radiation.
Ataxia Telangiectasia
Synaptic activity bidirectionally regulates a novel sequence-specific S-Q phosphoproteome in neurons.
Ataxia Telangiectasia
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
Ataxia Telangiectasia
Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway.
Ataxia Telangiectasia
Synergistic enhancement of NK cell-mediated cytotoxicity by combination of histone deacetylase inhibitor and ionizing radiation.
Ataxia Telangiectasia
Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway.
Ataxia Telangiectasia
T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23).
Ataxia Telangiectasia
T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency.
Ataxia Telangiectasia
T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.
Ataxia Telangiectasia
TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition.
Ataxia Telangiectasia
Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.
Ataxia Telangiectasia
Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways.
Ataxia Telangiectasia
Tannic Acid Induces the Mitochondrial Pathway of Apoptosis and S Phase Arrest in Porcine Intestinal IPEC-J2 Cells.
Ataxia Telangiectasia
Targeted cancer therapies based on the inhibition of DNA strand break repair.
Ataxia Telangiectasia
Targeted disruption of Ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer.
Ataxia Telangiectasia
Targeted integration of functional human ATM cDNA into genome mediated by HSV/AAV hybrid amplicon vector.
Ataxia Telangiectasia
Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival.
Ataxia Telangiectasia
Targeted next generation sequencing identified a high frequency genetic mutated profile in wood smoke exposure-related lung adenocarcinoma patients.
Ataxia Telangiectasia
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Ataxia Telangiectasia
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.
Ataxia Telangiectasia
Targeting Angiogenesis by Blocking the ATM-SerRS-VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth.
Ataxia Telangiectasia
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
Ataxia Telangiectasia
Targeting breast cancer stem-like cells using chloroquine encapsulated by a triphenylphosphonium-functionalized hyperbranched polymer.
Ataxia Telangiectasia
Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219.
Ataxia Telangiectasia
Targeting NPRL2 to enhance the efficacy of Olaparib in castration-resistant prostate cancer.
Ataxia Telangiectasia
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection.
Ataxia Telangiectasia
Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates ?-histone 2AX (?-H2AX) levels upon ionizing radiation.
Ataxia Telangiectasia
Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.
Ataxia Telangiectasia
Targeting the Ataxia Telangiectasia Mutated protein in cancer therapy.
Ataxia Telangiectasia
Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.
Ataxia Telangiectasia
Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death.
Ataxia Telangiectasia
Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner.
Ataxia Telangiectasia
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism.
Ataxia Telangiectasia
Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery.
Ataxia Telangiectasia
Telomere and ATM dynamics in CD4 T cell depletion in active and virus-suppressed HIV infection.
Ataxia Telangiectasia
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Ataxia Telangiectasia
Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging.
Ataxia Telangiectasia
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Ataxia Telangiectasia
Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential.
Ataxia Telangiectasia
Telomere Repeat-Binding Factor 2 Is Responsible for the Telomere Attachment to the Nuclear Membrane.
Ataxia Telangiectasia
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells.
Ataxia Telangiectasia
Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.
Ataxia Telangiectasia
Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms.
Ataxia Telangiectasia
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).
Ataxia Telangiectasia
Tetrandrine Enhances H2O2-Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes.
Ataxia Telangiectasia
The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses.
Ataxia Telangiectasia
The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.
Ataxia Telangiectasia
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.
Ataxia Telangiectasia
The antioxidant butylated hydroxyanisole potentiates the toxic effects of propylparaben in cultured mammalian cells.
Ataxia Telangiectasia
The antiproliferative effects of ataxia-telangiectasia mutated and ATM- and Rad3-related inhibitions and their enhancements with the cytotoxicity of DNA damaging agents in cholangiocarcinoma cells.
Ataxia Telangiectasia
The Arabidopsis MERISTEM DISORGANIZATION1 gene is required for maintenance of stem cells through reduction of the DNA damage level.
Ataxia Telangiectasia
The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species.
Ataxia Telangiectasia
The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response.
Ataxia Telangiectasia
The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study.
Ataxia Telangiectasia
The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCR? and IgH allelic exclusion.
Ataxia Telangiectasia
The Ataxia Telangiectasia mutated kinase controls Ig? allelic exclusion by inhibiting secondary V?-to-J? rearrangements.
Ataxia Telangiectasia
The Ataxia Telangiectasia Mutated Kinase Pathway Regulates IL-23 Expression by Human Dendritic Cells.
Ataxia Telangiectasia
The Ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants.
Ataxia Telangiectasia
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.
Ataxia Telangiectasia
The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect.
Ataxia Telangiectasia
The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a ?H2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.
Ataxia Telangiectasia
The ATM kinase signaling induced by the low-energy ?-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic ?-particles emitted by (32)P.
Ataxia Telangiectasia
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.
Ataxia Telangiectasia
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
Ataxia Telangiectasia
The ATM rs189037 G>A polymorphism is associated with the risk and prognosis of gastric cancer in Chinese individuals: A case-control study.
Ataxia Telangiectasia
The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation.
Ataxia Telangiectasia
The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.
Ataxia Telangiectasia
The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development.
Ataxia Telangiectasia
The ATM-SMC1 pathway is essential for activation of the chromium[VI]-induced S-phase checkpoint.
Ataxia Telangiectasia
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.
Ataxia Telangiectasia
The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin.
Ataxia Telangiectasia
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
Ataxia Telangiectasia
The catalytic subunit of DNA-dependent protein kinase is downstream of ATM and feeds forward oxidative stress in the selenium-induced senescence response.
Ataxia Telangiectasia
The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.
Ataxia Telangiectasia
The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage.
Ataxia Telangiectasia
The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons.
Ataxia Telangiectasia
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin.
Ataxia Telangiectasia
The Crucial Role of Cyclin-Dependent Kinase-5-Ataxia-Telangiectasia Mutated Axis in ICH-Induced Neuronal Injury of Rat Model.
Ataxia Telangiectasia
The CXXC finger 5 protein is required for DNA damage-induced p53 activation.
Ataxia Telangiectasia
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.
Ataxia Telangiectasia
The depletion of ATM inhibits colon cancer proliferation and migration via B56?2-mediated Chk1/p53/CD44 cascades.
Ataxia Telangiectasia
The development of ataxia telangiectasia mutated kinase inhibitors.
Ataxia Telangiectasia
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.
Ataxia Telangiectasia
The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
Ataxia Telangiectasia
The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
Ataxia Telangiectasia
The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.
Ataxia Telangiectasia
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation.
Ataxia Telangiectasia
The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.
Ataxia Telangiectasia
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Ataxia Telangiectasia
The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development.
Ataxia Telangiectasia
The effect of ataxia-telangiectasia mutated kinase-dependent hyperphosphorylation of checkpoint kinase-2 on oligodeoxynucleotide 7909 containing CpG motifs-enhanced sensitivity to X-rays in human lung adenocarcinoma A549 cells.
Ataxia Telangiectasia
The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation.
Ataxia Telangiectasia
The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models.
Ataxia Telangiectasia
The expression of genes related to adipocyte differentiation in pigs.
Ataxia Telangiectasia
The Fission Yeast Rad32(Mre11)-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint.
Ataxia Telangiectasia
The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment.
Ataxia Telangiectasia
The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.
Ataxia Telangiectasia
The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells.
Ataxia Telangiectasia
The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
Ataxia Telangiectasia
The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding.
Ataxia Telangiectasia
The heterochromatic barrier to DNA double strand break repair: how to get the entry visa.
Ataxia Telangiectasia
The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks.
Ataxia Telangiectasia
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
Ataxia Telangiectasia
The impact of oxidative DNA changes and ATM expression on morphological and functional activities on hepatocytes obtained from mesenchymal stem cells.
Ataxia Telangiectasia
The Impact of p53 Dysfunction in ATR Inhibitor Cytotoxicity and Chemo- and Radiosensitisation.
Ataxia Telangiectasia
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.
Ataxia Telangiectasia
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.
Ataxia Telangiectasia
The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.
Ataxia Telangiectasia
The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.
Ataxia Telangiectasia
The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment.
Ataxia Telangiectasia
The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity.
Ataxia Telangiectasia
The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.
Ataxia Telangiectasia
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication.
Ataxia Telangiectasia
The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.
Ataxia Telangiectasia
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
Ataxia Telangiectasia
The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis.
Ataxia Telangiectasia
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.
Ataxia Telangiectasia
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Ataxia Telangiectasia
The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum.
Ataxia Telangiectasia
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
Ataxia Telangiectasia
The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.
Ataxia Telangiectasia
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.
Ataxia Telangiectasia
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Ataxia Telangiectasia
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
Ataxia Telangiectasia
The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.
Ataxia Telangiectasia
The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells.
Ataxia Telangiectasia
The nucleo-shuttling of the ATM protein as a basis for a novel theory of radiation response: resolution of the linear-quadratic model.
Ataxia Telangiectasia
The Nucleoshuttling of the ATM Protein: A Unified Model to Describe the Individual Response to High- and Low-Dose of Radiation?
Ataxia Telangiectasia
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
Ataxia Telangiectasia
The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.
Ataxia Telangiectasia
The ovarian DNA damage repair response is induced prior to phosphoramide mustard-induced follicle depletion, and ataxia telangiectasia mutated inhibition prevents PM-induced follicle depletion.
Ataxia Telangiectasia
The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
Ataxia Telangiectasia
The p53 pathway induction is not primarily dependent on Ataxia Telangiectasia Mutated (ATM) gene activity after fludarabine treatment in chronic lymphocytic leukemia cells.
Ataxia Telangiectasia
The p53-53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure.
Ataxia Telangiectasia
The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.
Ataxia Telangiectasia
The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo.
Ataxia Telangiectasia
The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair.
Ataxia Telangiectasia
The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks.
Ataxia Telangiectasia
The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis.
Ataxia Telangiectasia
The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11.
Ataxia Telangiectasia
The Protein Arginine Methylase 5 (PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage.
Ataxia Telangiectasia
The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.
Ataxia Telangiectasia
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Ataxia Telangiectasia
The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks.
Ataxia Telangiectasia
The RAG2 C terminus suppresses genomic instability and lymphomagenesis.
Ataxia Telangiectasia
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.
Ataxia Telangiectasia
The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function.
Ataxia Telangiectasia
The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.
Ataxia Telangiectasia
The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage.
Ataxia Telangiectasia
The Role and Mechanism of ATM-Mediated Autophagy in the Transition From Hyper-Radiosensitivity to Induced Radioresistance in Lung Cancer Under Low-Dose Radiation.
Ataxia Telangiectasia
The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons.
Ataxia Telangiectasia
The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death.
Ataxia Telangiectasia
The role of DNA damage response proteins at telomeres--an "integrative" model.
Ataxia Telangiectasia
The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage.
Ataxia Telangiectasia
The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs.
Ataxia Telangiectasia
The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.
Ataxia Telangiectasia
The role of the ataxia telangiectasia mutated gene in lung cancer: recent advances in research.
Ataxia Telangiectasia
The role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotection.
Ataxia Telangiectasia
The Role of the Nuclear Factor ?B Pathway in the Cellular Response to Low and High Linear Energy Transfer Radiation.
Ataxia Telangiectasia
The Roles of 4?-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells.
Ataxia Telangiectasia
The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.
Ataxia Telangiectasia
The telomere deprotection response is functionally distinct from the genomic DNA damage response.
Ataxia Telangiectasia
The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.
Ataxia Telangiectasia
The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.
Ataxia Telangiectasia
The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-?-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex.
Ataxia Telangiectasia
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.
Ataxia Telangiectasia
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.
Ataxia Telangiectasia
Theasaponin E1 Inhibits Platinum-Resistant Ovarian Cancer Cells through Activating Apoptosis and Suppressing Angiogenesis.
Ataxia Telangiectasia
Therapeutic effect of sodium iodide symporter gene therapy combined with external beam radiotherapy and targeted drugs that inhibit DNA repair.
Ataxia Telangiectasia
Therapeutic Potential of the miRNA-ATM Axis in the Management of Tumor Radioresistance.
Ataxia Telangiectasia
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
Ataxia Telangiectasia
Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer.
Ataxia Telangiectasia
Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints.
Ataxia Telangiectasia
Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex.
Ataxia Telangiectasia
Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification.
Ataxia Telangiectasia
Threonine 2609 phosphorylation of the DNA-dependent Protein Kinase is a critical prerequisite for epidermal growth factor receptor mediated radiation resistance.
Ataxia Telangiectasia
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
Ataxia Telangiectasia
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.
Ataxia Telangiectasia
Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.
Ataxia Telangiectasia
Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer.
Ataxia Telangiectasia
Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia.
Ataxia Telangiectasia
Time, Dose and Ataxia Telangiectasia Mutated (ATM) Status Dependency of Coding and Noncoding RNA Expression after Ionizing Radiation Exposure.
Ataxia Telangiectasia
Tip60 in DNA damage response and growth control: many tricks in one HAT.
Ataxia Telangiectasia
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.
Ataxia Telangiectasia
TLC388 Induces DNA Damage and G2 Phase Cell Cycle Arrest in Human Non-Small Cell Lung Cancer Cells.
Ataxia Telangiectasia
TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.
Ataxia Telangiectasia
TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.
Ataxia Telangiectasia
Topoisomerase II?-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation.
Ataxia Telangiectasia
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms.
Ataxia Telangiectasia
Transcription Factors in the Cellular Response to Charged Particle Exposure.
Ataxia Telangiectasia
Transcriptional regulation of ataxia-telangiectasia and Rad3-related protein by activated p21-activated kinase-1 protects keratinocytes in UV-B-induced premalignant skin lesions.
Ataxia Telangiectasia
Transcriptome Analysis of Caco-2 Cells upon the Exposure of Mycotoxin Deoxynivalenol and Its Acetylated Derivatives.
Ataxia Telangiectasia
Transforming growth factor-? regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM.
Ataxia Telangiectasia
Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis.
Ataxia Telangiectasia
Transition in Survival From Low-Dose Hyper-Radiosensitivity to Increased Radioresistance Is Independent of Activation of ATM SER1981 Activity.
Ataxia Telangiectasia
Translational initiation regulated by ATM in dendritic cells development.
Ataxia Telangiectasia
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy.
Ataxia Telangiectasia
Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
Ataxia Telangiectasia
Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes.
Ataxia Telangiectasia
Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-? by macrophages: role of the DNA damage response.
Ataxia Telangiectasia
Tug of War between Survival and Death: Exploring ATM Function in Cancer.
Ataxia Telangiectasia
Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.
Ataxia Telangiectasia
Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-?1 in orchestrating profibrotic responses.
Ataxia Telangiectasia
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.
Ataxia Telangiectasia
Twelve novel Atm mutations identified in Chinese ataxia telangiectasia patients.
Ataxia Telangiectasia
Two-stage case-control study of common ATM gene variants in relation to breast cancer risk.
Ataxia Telangiectasia
Type 1 diabetes upregulates metastasis-associated protein 1- phosphorylated histone 2AX signaling in the testis.
Ataxia Telangiectasia
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Ataxia Telangiectasia
Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.
Ataxia Telangiectasia
UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.
Ataxia Telangiectasia
Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells.
Ataxia Telangiectasia
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination.
Ataxia Telangiectasia
Unusual case of leukemic mantle cell lymphoma with amplified CCND1/IGH fusion gene.
Ataxia Telangiectasia
Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease.
Ataxia Telangiectasia
USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status.
Ataxia Telangiectasia
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.
Ataxia Telangiectasia
Utilizing protein phosphatase inhibitors to define PP2A as a regulator of ataxia-telangiectasia mutated.
Ataxia Telangiectasia
UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity.
Ataxia Telangiectasia
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.
Ataxia Telangiectasia
Validation of the cell cycle G(2) delay assay in assessing ionizing radiation sensitivity and breast cancer risk.
Ataxia Telangiectasia
Vanillin protects human keratinocyte stem cells against ultraviolet B irradiation.
Ataxia Telangiectasia
Variation in Telangiectasia Predisposing Genes Is Associated With Overall Radiation Toxicity.
Ataxia Telangiectasia
Variation of ATM Gene Expression in Peripheral Blood Cells of Sporadic Breast Carcinomas in Iranian Patients.
Ataxia Telangiectasia
Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.
Ataxia Telangiectasia
Vasculogenic Mimicry Formation Predicts Tumor Progression in Oligodendroglioma.
Ataxia Telangiectasia
Venetoclax and dexamethasone synergize with inotuzumab ozogamicin-induced DNA damage signaling in B-lineage ALL.
Ataxia Telangiectasia
Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.
Ataxia Telangiectasia
Walking forward: a program designed to lower cancer mortality rates among American Indians in western South Dakota.
Ataxia Telangiectasia
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Ataxia Telangiectasia
When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers.
Ataxia Telangiectasia
Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia.
Ataxia Telangiectasia
Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis.
Ataxia Telangiectasia
WIP1, a homeostatic regulator of the DNA damage response, is targeted by HIPK2 for phosphorylation and degradation.
Ataxia Telangiectasia
Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002.
Ataxia Telangiectasia
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks.
Ataxia Telangiectasia
Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis.
Ataxia Telangiectasia
Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.
Ataxia Telangiectasia
XCIND as a genetic disease of X-irradiation hypersensitivity and cancer susceptibility.
Ataxia Telangiectasia
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.
Ataxia Telangiectasia
XRCC2 Regulates Replication Fork Progression during dNTP Alterations.
Ataxia Telangiectasia
YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases.
Ataxia Telangiectasia
ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM.
Ataxia Telangiectasia
Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation.
Ataxia Telangiectasia
ZnO nanoparticles-associated mitochondrial stress-induced apoptosis and G2/M arrest in HaCaT cells: a mechanistic approach.
Ataxia Telangiectasia
[Adjuvant irradiation in breast cancer patients with ATM gene heterozygous mutations: Special focus on clinical efficacy/toxicity.]
Ataxia Telangiectasia
[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].
Ataxia Telangiectasia
[Association between single nucleotide polymorphism locus rs189037 in the promoter of ATM gene and nasopharyngeal carcinoma susceptibility in Cantonese].
Ataxia Telangiectasia
[Ataxia-telangiectasia mutated gene and breast cancer susceptibility]
Ataxia Telangiectasia
[Complete heart block and asystole in a child with ataxia-telangiectasia].
Ataxia Telangiectasia
[Employing DNA Damage Response Inhibitors to Enhance Chemosensitivity of Ovarian Carcinoma Cells].
Ataxia Telangiectasia
[Jaridonin, a new diterpenoid from Isodon rubescens, induces cell cycle arrest in gastric cancer cells through activating ataxia telangiectasia mutated kinase].
Ataxia Telangiectasia
[Knockdown of DNA-PKcs inhibits cell cycle and its mechanism of drug-resistant Bel7402/5-Fu hepatocellular carcinoma cells].
Ataxia Telangiectasia
[miR-18a enhances the radiosensitivity of nasopharyngeal carcinoma cells through inducing autophagy].
Ataxia Telangiectasia
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Ataxia Telangiectasia
[Relationship of HepG2 cell sensitivity to continuous low dose-rate irradiation with ataxia-telangiectasia mutated phosphorylation]
Ataxia Telangiectasia
[Research advance of retinal pathological angiogenesis related to ATM protein kinase].
Ataxia Telangiectasia
[Single nucleotide polymorphisms and point mutations of ataxia telangiectasia mutated gene in Chinese of Han ethnicity.]
Ataxia Telangiectasia
[Study on the Effect of Overexpression of miR-18a on Cellular Proliferation and Migration by Targeting ATM in Human Colorectal Cancer Cells].
Ataxia Telangiectasia
[Suppression of ATR reverses the cisplatin resistance in ovarian cancer SKOV3 cells].
Ataxia Telangiectasia
[The Role of DNA Double-strain Damage Repairing Mechanisms in Diabetic Atheroscolersis].
Ataxia Telangiectasia
[Topoisomerase inhibitor upregulates MICA/B expression in breast cancer cells through ATM/ATR and NF-?B pathway].
Ataxia Telangiectasia
[Up-regulation of major histocompatibility complex class I-related molecules A (MICA) induced by 5-aza-2'-deoxycytidine.]
Atherosclerosis
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Atherosclerosis
Absence of Gravin Mediated Signaling Inhibits Development of High Fat Diet-Induced Hyperlipidemia and Atherosclerosis.
Atherosclerosis
Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice.
Atherosclerosis
Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease.
Atherosclerosis
ALK5 deficiency inhibits macrophage inflammation and lipid loading by targeting KLF4.
Atherosclerosis
Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque.
Atherosclerosis
CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REG?.
Atherosclerosis
Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis.
Atherosclerosis
Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway.
Atherosclerosis
Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
Atherosclerosis
Differential responsiveness of early- and late-passage endothelial cells to shear stress.
Atherosclerosis
Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.
Atherosclerosis
Identification and characterization of the druggable kinase targets of olmesartan and its analogues from a systematic kinase-chemical interaction profile in atherosclerosis.
Atherosclerosis
Individual Radiosensitivity Assessment of the Families of Ataxia-Telangiectasia Patients by G2-Checkpoint Abrogation.
Atherosclerosis
Inhibition of c-Jun N-terminal Kinase Attenuates Low Shear Stress-Induced Atherogenesis in Apolipoprotein E-deficient Mice.
Atherosclerosis
Inhibition of p90RSK is critical to abolish Angiotensin II-induced rat aortic smooth muscle cell proliferation and migration.
Atherosclerosis
Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation.
Atherosclerosis
Knockdown of lnc-KCNC3-3:1 Alleviates the Development of Atherosclerosis via Downregulation of JAK1/STAT3 Signaling Pathway.
Atherosclerosis
Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
Atherosclerosis
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Atherosclerosis
MicroRNA-145 alleviates high glucose-induced proliferation and migration of vascular smooth muscle cells through targeting ROCK1.
Atherosclerosis
Over-expression of angiotensin II type 2 receptor (agtr2) reduces atherogenesis and modulates LOX-1, endothelial nitric oxide synthase and heme-oxygenase-1 expression.
Atherosclerosis
Pim-2 kinase inhibits inflammation by suppressing the mTORC1 pathway in atherosclerosis.
Atherosclerosis
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Atherosclerosis
Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
Atherosclerosis
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
Atherosclerosis
SNHG6 modulates oxidized low-density lipoprotein-induced endothelial cells injury through miR-135a-5p/ROCK in atherosclerosis.
Atherosclerosis
Structure-based design of small molecule and peptide inhibitors for selective targeting of ROCK1: an integrative computational approach.
Atherosclerosis
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Atherosclerosis
Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice.
Atherosclerosis
The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study.
Atherosclerosis
The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.
Atherosclerosis
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.
Atherosclerosis
[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].
Atherosclerosis
[Effect of Buyang Huanwu Decoction on mRNA Expressions of Aorta Rho Kinase and NF-?B p65 in Atherosclerosis Model Rats].
Atrial Fibrillation
Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.
Atrial Fibrillation
c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.
Atrial Fibrillation
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation.
Atrial Fibrillation
Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation.
Atrial Fibrillation
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Atrial Fibrillation
Circ-Zfp644 acts as a pro-hypertrophic mediator in an Ang-II induced in vitro myocardial hypertrophy model.
Atrial Fibrillation
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Atrial Fibrillation
Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.
Atrial Fibrillation
Inhibitions of late INa and CaMKII act synergistically to prevent ATX-II-induced atrial fibrillation in isolated rat right atria.
Atrial Fibrillation
Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.
Atrial Fibrillation
Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use?
Atrial Fibrillation
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
Atrial Fibrillation
Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes.
Atrial Fibrillation
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.
Atrial Fibrillation
The Role of CaMKII Overexpression and Oxidation in Atrial Fibrillation-A Simulation Study.
Atrial Fibrillation
The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.
Atrial Fibrillation
Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats.
Atrial Premature Complexes
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Atrial Premature Complexes
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.
Atrioventricular Block
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Autoimmune Diseases
Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha.
Autoimmune Diseases
BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells.
Autoimmune Diseases
BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells.
Autoimmune Diseases
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
Autoimmune Diseases
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Autoimmune Diseases
hsBAFF promotes proliferation and survival in cultured B lymphocytes via calcium signaling activation of mTOR pathway.
Autoimmune Diseases
Involvement of DNA-PKcs in the IL-6 and IL-12 Response to CpG-ODN Is Mediated by Its Interaction with TRAF6 in Dendritic Cells.
Autoimmune Diseases
Long non-coding RNA growth arrest-specific transcript 5 regulates rheumatoid arthritis by targeting homeodomain-interacting protein kinase 2.
Autoimmune Diseases
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.
Autoimmune Diseases
Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.
Avian Leukosis
Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek's disease virus.
Avitaminosis
B Vitamin Deficiency Promotes Tau Phosphorylation Through Regulation of GSK3beta and PP2A.
Avitaminosis
B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A.
Azoospermia
A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.
Azoospermia
Gene and histomorphology alteration analysis in spermatogenesis arrest mouse model: a probable novel approach for infertility.
Azoospermia
Mutation screening and association study of the TSSK4 Gene in Chinese infertile men with impaired spermatogenesis.
Azoospermia
Some Single Nucleotide Polymorphisms of the TSSK2 Gene May Be Associated with Human Spermatogenesis Impairment.
Azoospermia
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Bacterial Infections
A Proteasome-regulated glycogen synthase kinase-3 modulates disease response in plants.
Bacterial Infections
Anthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock.
Bacterial Infections
c-Jun N-terminal kinase (JNK) is involved in immune defense against bacterial infection in Crassostrea hongkongensis.
Bacterial Infections
Critical Role of Glycogen Synthase Kinase-3? in Regulating the Avian Heterophil Response to Salmonella enterica Serovar Enteritidis.
Bacterial Infections
Genome-wide identification of PTI1 family in Setaria italica and salinity-responsive functional analysis of SiPTI1-5.
Bacterial Infections
Glycogen Synthase Kinase 3? Is the Main Isoform That Regulates the Transcription Factors Nuclear Factor-Kappa B and cAMP Response Element Binding in Bovine Endothelial Cells Infected with
Bacterial Infections
Identification of the 14-3-3 ?/?-A protein as a novel maternal peptidoglycan-binding protein that protects embryos of zebrafish against bacterial infections.
Bacterial Infections
LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson's.
Bacterial Infections
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Bacterial Infections
Recognition of Lipopolysaccharide and Activation of NF-?B by Cytosolic Sensor NOD1 in Teleost Fish.
Bacterial Infections
Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation.
Barrett Esophagus
Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia.
Barth Syndrome
Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome.
Basal Cell Nevus Syndrome
Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors?
Behcet Syndrome
Association of LACC1, CEBPB-PTPN1, RIPK2 and ADO-EGR2 with ocular Behcet's disease in a Chinese Han population.
Bile Duct Neoplasms
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
Biliary Tract Neoplasms
Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients.
Blast Crisis
ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia.
Blast Crisis
LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.
Blast Crisis
Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.
Blister
Coordinated changes in cell membrane and cytoplasm during maturation of apoptotic bleb.
Blister
The Diaphanous-related Formin FHOD1 Associates with ROCK1 and Promotes Src-dependent Plasma Membrane Blebbing.
Bloom Syndrome
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Bluetongue
Cellular Casein Kinase 2 and Protein Phosphatase 2A Modulate Replication Site Assembly of Bluetongue Virus.
Bone Diseases
Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.
Bone Diseases
Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats.
Bone Diseases
Osteocytes Specific GSK3 Inhibition Affects In Vitro Osteogenic Differentiation.
Bone Diseases
Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.
Bone Diseases, Metabolic
Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation.
Bone Diseases, Metabolic
Inhibition of glycogen synthase kinase-3beta attenuates glucocorticoid-induced bone loss.
Bone Diseases, Metabolic
Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses.
Bone Marrow Failure Disorders
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
Bone Marrow Failure Disorders
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.
Bone Neoplasms
Activation of spinal TDAG8 and its downstream PKA signaling pathway contribute to bone cancer pain in rats.
Bone Neoplasms
Blocking mammalian target of rapamycin alleviates bone cancer pain and morphine tolerance via µ-opioid receptor.
Bone Neoplasms
Cellular and molecular mechanisms of calcium/calmodulin-dependent protein kinase II in chronic pain.
Bone Neoplasms
Electroacupuncture Attenuates Morphine Tolerance in Rats with Bone Cancer Pain by Inhibiting PI3K/Akt/JNK1/2 Signaling Pathway in the Spinal Dorsal Horn.
Bone Neoplasms
The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice.
Bone Resorption
CaMKII(?) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway.
Bone Resorption
Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption.
Bone Resorption
Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization.
Bone Resorption
Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II.
Bone Resorption
Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.
Bone Resorption
Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model.
Bone Resorption
Prostaglandin E2 directly inhibits bone-resorbing activity of isolated mature osteoclasts mainly through the EP4 receptor.
Bone Resorption
PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells.
Bone Resorption
Small molecule GSK-3 antagonists play a pivotal role in reducing the local inflammatory response, in promoting resident stem cell activation and in improving tissue repairing in regenerative dentistry.
Bone Resorption
Surface modification of titanium manufactured through selective laser melting inhibited osteoclast differentiation through mitogen-activated protein kinase signaling pathway.
Bone Resorption
Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation.
Borna Disease
Borna disease virus P-protein is phosphorylated by protein kinase Cepsilon and casein kinase II.
Bowen's Disease
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Brachydactyly
A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2.
Bradycardia
Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway.
Bradycardia
Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.
Bradycardia
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Bradycardia
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability.
Brain Concussion
Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.
Brain Contusion
c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion.
Brain Contusion
Temporal and regional changes in IGF-1/IGF-1R signaling in the mouse brain following traumatic brain injury.
Brain Contusion
Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats.
Brain Death
Myocardial protective effects of a c-Jun N-terminal kinase inhibitor in rats with brain death.
Brain Diseases
14-3-3 protein detection in the cerebrospinal fluid of patients with influenza-associated encephalopathy.
Brain Diseases
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Brain Diseases
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Brain Diseases
Cerebrospinal fluid non-phosphorylated tau in the differential diagnosis of Creutzfeldt-Jakob disease: a comparative prospective study with 14-3-3.
Brain Diseases
Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.
Brain Diseases
Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like episodes.
Brain Diseases
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Brain Diseases
Detection of 14-3-3 protein in the CSF of a patient with Hashimoto's encephalopathy.
Brain Diseases
Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies.
Brain Diseases
Glycogen synthase kinase-3 as a therapeutic target for cognitive dysfunction in neuropsychiatric disorders.
Brain Diseases
GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke.
Brain Diseases
Lethal neonatal rigidity and multifocal seizure syndrome with a new mutation in BRAT1.
Brain Diseases
Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?
Brain Diseases
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Brain Diseases
Prolongation of life in rats with malignant glioma by intranasal siRNA/drug co-delivery to the brain with cell-penetrating peptide-modified micelles.
Brain Diseases
Radiosynthesis and in Vivo Evaluation of [(11)C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain.
Brain Diseases
Sporadic Creutzfeldt-Jakob Disease With Unilateral Symptoms in the Setting of Metastatic Renal Cell Carcinoma.
Brain Diseases
The 14-3-3 brain protein and transmissible spongiform encephalopathy.
Brain Diseases
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
Brain Diseases
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Brain Diseases
The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.
Brain Diseases
Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent.
Brain Diseases
What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.
Brain Diseases
[A case of steroid-responsive encephalopathy with positive 14-3-3 protein of the cerebrospinal fluid clinically resembling Creutzfelt-Jakob disease]
Brain Diseases
[Diagnosis of transmissible spongiform encephalopathies in Spain. Population perspective]
Brain Edema
Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice.
Brain Edema
Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.
Brain Edema
Effects of isoflurane on brain inflammation after subarachnoid hemorrhage in mice.
Brain Edema
Ghrelin alleviates early brain injury after subarachnoid hemorrhage via the PI3K/Akt signaling pathway.
Brain Edema
Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
Brain Edema
Isoflurane preconditioning protects rat brain from ischemia reperfusion injury via up-regulating the HIF-1? expression through Akt/mTOR/s6K activation.
Brain Edema
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway.
Brain Edema
[Effect of thyroxine on the expression of HIF-1? after aneurysmal subarachnoid hemorrhage in rat brain and its mechanism].
Brain Infarction
Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection.
Brain Infarction
Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling.
Brain Infarction
Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion.
Brain Infarction
Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition.
Brain Injuries
A Combined Proteomics and Bioinformatics Approach Reveals Novel Signaling Pathways and Molecular Targets After Intracerebral Hemorrhage.
Brain Injuries
Activation of the Protein Kinase B (Akt) Reduces Nur77-induced Apoptosis During Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rat.
Brain Injuries
Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death.
Brain Injuries
Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats.
Brain Injuries
Astrocytic Expression of CTMP Following an Excitotoxic Lesion in the Mouse Hippocampus.
Brain Injuries
Bi-directional genetic modulation of GSK-3? exacerbates hippocampal neuropathology in experimental status epilepticus.
Brain Injuries
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Brain Injuries
Brain injury induces HIF-1?-dependent transcriptional activation of LRRK2 that exacerbates brain damage.
Brain Injuries
Brain ischemia/reperfusion-induced expression of DP5 and its interaction with Bcl-2, thus freeing Bax from Bcl-2/Bax dimmers are mediated by c-Jun N-terminal kinase (JNK) pathway.
Brain Injuries
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats.
Brain Injuries
Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders.
Brain Injuries
Delayed administration of a potent cyclin dependent kinase and glycogen synthase kinase 3 beta inhibitor produces long-term neuroprotection in a hypoxia-ischemia model of brain injury.
Brain Injuries
Differential activation of ERK, p38, and JNK MAPK by nociceptin/orphanin FQ in the potentiation of prostaglandin cerebrovasoconstriction after brain injury.
Brain Injuries
Differential early mitogen-activated protein kinase activation in hyperglycemic ischemic brain injury in the rat.
Brain Injuries
Dual inhibitory roles of geldanamycin on the c-Jun NH(2)-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury.
Brain Injuries
Effects of isoflurane on brain inflammation after subarachnoid hemorrhage in mice.
Brain Injuries
Estradiol prevents the injury-induced decrease of Akt/glycogen synthase kinase 3beta phosphorylation.
Brain Injuries
Etanercept Alleviates Early Brain Injury Following Experimental Subarachnoid Hemorrhage and the Possible Role of Tumor Necrosis Factor-? and c-Jun N-Terminal Kinase Pathway.
Brain Injuries
Glucagon Protects Against Impaired NMDA-Mediated Cerebrovasodilation and Cerebral Autoregulation during Hypotension after Brain Injury by Activating cAMP Protein Kinase A and Inhibiting Upregulation of tPA.
Brain Injuries
Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.
Brain Injuries
GSK-3?/mTORC1 Couples Synaptogenesis and Axonal Repair to Reduce Hypoxia Ischemia-Mediated Brain Injury in Neonatal Rats.
Brain Injuries
Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain.
Brain Injuries
Increased expression of receptor for advanced glycation end-products worsens focal brain ischemia in diabetic rats.
Brain Injuries
Inhibition of c-Jun N-terminal kinase ameliorates early brain injury after subarachnoid hemorrhage through inhibition of a Nur77 dependent apoptosis pathway.
Brain Injuries
Inhibition of HDAC4 Attenuated JNK/c-Jun-Dependent Neuronal Apoptosis and Early Brain Injury Following Subarachnoid Hemorrhage by Transcriptionally Suppressing MKK7.
Brain Injuries
Insulin Receptor Substrate-1 Activation Mediated p53 Downregulation Protects Against Hypoxic-Ischemia in the Neonatal Brain.
Brain Injuries
JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke.
Brain Injuries
K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
Brain Injuries
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway.
Brain Injuries
LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats.
Brain Injuries
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.
Brain Injuries
Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3.
Brain Injuries
Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway.
Brain Injuries
Neuroprotection against ischemic brain injury by a small peptide inhibitor of c-Jun N-terminal kinase (JNK) via nuclear and non-nuclear pathways.
Brain Injuries
nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion.
Brain Injuries
Perinatal nicotine exposure alters Akt/GSK-3?/mTOR/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain.
Brain Injuries
Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats.
Brain Injuries
Progesterone alleviates hypoxic-ischemic brain injury via the Akt/GSK-3? signaling pathway.
Brain Injuries
Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method.
Brain Injuries
RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats.
Brain Injuries
Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats.
Brain Injuries
Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
Brain Injuries
Remifentanil preconditioning alleviating brain damage of cerebral ischemia reperfusion rats by regulating the JNK signal pathway and TNF-?/TNFR1 signal pathway.
Brain Injuries
Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage.
Brain Injuries
Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury.
Brain Injuries
Targeting the Dvl-1/?-arrestin2/JNK3 interaction disrupts Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during cerebral ischemia reperfusion.
Brain Injuries
The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression.
Brain Injuries
The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus.
Brain Injuries
Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation.
Brain Injuries
[Effect of Schisandra chinensis lignans on neuronal apoptosis and p-AKT expression of rats in cerebral ischemia injury model].
Brain Injuries
[Significance and expression of FKHR and AKT after subarachnoid hemorrhage in rat brain cortex].
Brain Injuries, Diffuse
[Effect of expression of c-jun N-terminal kinase on neuron autophagy following diffuse brain injury in rats].
Brain Injuries, Traumatic
?-Synuclein is a pathological link and therapeutic target for Parkinson's disease and traumatic brain injury.
Brain Injuries, Traumatic
Are GLP-1 receptor agonists useful against traumatic brain injury?
Brain Injuries, Traumatic
Brain injury induces HIF-1?-dependent transcriptional activation of LRRK2 that exacerbates brain damage.
Brain Injuries, Traumatic
Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability.
Brain Injuries, Traumatic
Different functions of HIPK2 and CtBP2 in traumatic brain injury.
Brain Injuries, Traumatic
Expression of serine/threonine kinase receptors in traumatic brain injury.
Brain Injuries, Traumatic
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Brain Injuries, Traumatic
Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?
Brain Injuries, Traumatic
Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats.
Brain Injuries, Traumatic
Inhibition of c-Jun N-Terminal Kinase Protects Against Brain Damage and Improves Learning and Memory After Traumatic Brain Injury in Adult Mice.
Brain Injuries, Traumatic
Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury.
Brain Injuries, Traumatic
Inhibition of glycogen synthase kinase-3: an emerging target in the treatment of traumatic brain injury.
Brain Injuries, Traumatic
Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat.
Brain Injuries, Traumatic
LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats.
Brain Injuries, Traumatic
Magnesium Lithospermate B Implicates 3'-5'-Cyclic Adenosine Monophosphate/Protein Kinase A Pathway and N-Methyl-d-Aspartate Receptors in an Experimental Traumatic Brain Injury.
Brain Injuries, Traumatic
Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor-dependent pathway.
Brain Injuries, Traumatic
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
Brain Injuries, Traumatic
Small interfering RNA directed against CTMP reduces acute traumatic brain injury in a mouse model by activating Akt.
Brain Injuries, Traumatic
The selectivity and promiscuity of brain-neuroregenerative inhibitors between ROCK1 and ROCK2 isoforms: An integration of SB-QSSR modelling, QM/MM analysis and in vitro kinase assay.
Brain Ischemia
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Brain Ischemia
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Brain Ischemia
Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma.
Brain Ischemia
Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia.
Brain Ischemia
Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1.
Brain Ischemia
Altered Prion protein expression pattern in CSF as a biomarker for Creutzfeldt-Jakob disease.
Brain Ischemia
Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats.
Brain Ischemia
Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Brain Ischemia
c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury.
Brain Ischemia
Ca2+/calmodulin-dependent protein kinase II in postsynaptic densities after reversible cerebral ischemia in rats.
Brain Ischemia
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Brain Ischemia
Cerebral ischemia induces transient intracellular redistribution and intranuclear translocation of the raf proto-oncogene product in hippocampal pyramidal cells.
Brain Ischemia
Changes of Ca2+/calmodulin-dependent protein kinase-II after transient ischemia in gerbil hippocampus.
Brain Ischemia
Co-induction of alphaB-crystallin and MAPKAPK-2 in astrocytes in the penumbra after transient focal cerebral ischemia.
Brain Ischemia
D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats.
Brain Ischemia
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Brain Ischemia
Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation.
Brain Ischemia
Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia.
Brain Ischemia
Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway.
Brain Ischemia
Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion.
Brain Ischemia
Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex.
Brain Ischemia
Distinct Roles of ROCK1 and ROCK2 on the Cerebral Ischemia Injury and Subsequently Neurodegenerative Changes.
Brain Ischemia
Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.
Brain Ischemia
Dynamic Changes in miR-126 Expression in the Hippocampus and Penumbra Following Experimental Transient Global and Focal Cerebral Ischemia-Reperfusion.
Brain Ischemia
Effects of FK506 on the translocation of protein kinase C and CaM kinase II in the gerbil hippocampal CA1 neurons.
Brain Ischemia
Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects against cerebral infarction: Involvement of the phosphatidylinositol-3 kinase/Akt pathway.
Brain Ischemia
Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor.
Brain Ischemia
Exogenous nitric oxide negatively regulates c-Jun N-terminal kinase activation via inhibiting endogenous NO-induced S-nitrosylation during cerebral ischemia and reperfusion in rat hippocampus.
Brain Ischemia
GHB analogs confer neuroprotection through specific interaction with the CaMKII? hub domain.
Brain Ischemia
Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.
Brain Ischemia
Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential.
Brain Ischemia
Heme oxygenase-1 regulates the JNK signaling pathway through the MLK3-MKK7-JNK3 signaling module in brain ischemia injury.
Brain Ischemia
Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex.
Brain Ischemia
Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation.
Brain Ischemia
Increased expression of receptor for advanced glycation end-products worsens focal brain ischemia in diabetic rats.
Brain Ischemia
Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
Brain Ischemia
Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
Brain Ischemia
Lack of neuroprotection of inhibitory peptides targeting Jun/JNK after transient focal cerebral ischemia in spontaneously hypertensive rats.
Brain Ischemia
Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia-ischemia.
Brain Ischemia
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Brain Ischemia
Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia.
Brain Ischemia
Mild hypothermia decreases GSK3beta expression following global cerebral ischemia.
Brain Ischemia
N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel activation mediate proline-rich tyrosine kinase 2 phosphorylation during cerebral ischemia in rats.
Brain Ischemia
N-methyl-D-aspartate receptors mediate diphosphorylation of extracellular signal-regulated kinases through Src family tyrosine kinases and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus after cerebral ischemia.
Brain Ischemia
Necrotic death of neurons following an excitotoxic insult is prevented by a peptide inhibitor of c-jun N-terminal kinase.
Brain Ischemia
Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats.
Brain Ischemia
Neuroprotection by inhibiting the c-Jun N-terminal kinase pathway after cerebral ischemia occurs independently of interleukin-6 and keratinocyte-derived chemokine (KC/CXCL1) secretion.
Brain Ischemia
Neuroprotective Effect of TAT-14-3-3? Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats.
Brain Ischemia
Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia.
Brain Ischemia
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Brain Ischemia
Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat.
Brain Ischemia
Opposite reaction of ERK and JNK in ischemia vulnerable and resistant regions of hippocampus: involvement of mitochondria.
Brain Ischemia
Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Brain Ischemia
Persistent translocation of Ca2+/calmodulin-dependent protein kinase II to synaptic junctions in the vulnerable hippocampal CA1 region following transient ischemia.
Brain Ischemia
Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain.
Brain Ischemia
Post-ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia.
Brain Ischemia
Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies.
Brain Ischemia
Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats.
Brain Ischemia
PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus.
Brain Ischemia
Quercetin Attenuates Cell Apoptosis in Focal Cerebral Ischemia Rat Brain Via Activation of BDNF-TrkB-PI3K/Akt Signaling Pathway.
Brain Ischemia
Reduction of ischemic brain injury by topical application of insulin-like growth factor-I after transient middle cerebral artery occlusion in rats.
Brain Ischemia
Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage.
Brain Ischemia
Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons.
Brain Ischemia
Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury.
Brain Ischemia
Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling.
Brain Ischemia
The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia.
Brain Ischemia
The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways.
Brain Ischemia
The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.
Brain Ischemia
The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion.
Brain Ischemia
Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation.
Brain Ischemia
[Effect of electroacupuncture on CD 34+ endothelial progenitor cell counts in bone marrow and peripheral blood in focal cerebral ischemia/reperfusion rats].
Brain Ischemia
[Effect of Schisandra chinensis lignans on neuronal apoptosis and p-AKT expression of rats in cerebral ischemia injury model].
Brain Ischemia
[Influence of acupuncture intervention on neurologic deficits, cerebrocortical cell apoptosis and Protein kinase A expression in rats with focal cerebral ischemia].
Brain Neoplasms
A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.
Brain Neoplasms
AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.
Brain Neoplasms
Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.
Brain Neoplasms
Development of dual casein kinase 1?/1? (CK1?/?) inhibitors for treatment of breast cancer.
Brain Neoplasms
Diffusible Factors Secreted by Glioblastoma and Medulloblastoma Cells Induce Oxidative Stress in Bystander Neural Stem Progenitors.
Brain Neoplasms
Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications.
Brain Neoplasms
Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: a potential therapeutic strategy for inhibition of tumor angiogenesis.
Brain Neoplasms
Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors.
Brain Neoplasms
Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors.
Brain Neoplasms
Identification of an EGFRvIII-JNK2-HGF/c-Met-Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion.
Brain Neoplasms
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy.
Brain Neoplasms
Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma.
Brain Neoplasms
Preclinical Pharmacological Evaluation of a Novel Multiple Kinase Inhibitor, ON123300, in Brain Tumor Models.
Brain Neoplasms
Promoter methylation status of multiple genes in brain metastases of solid tumors.
Brain Neoplasms
Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells.
Brain Neoplasms
Rapid induction of the Grp78 gene by cooperative actions of okadaic acid and heat-shock in 9L rat brain tumor cells--involvement of a cAMP responsive element-like promoter sequence and a protein kinase A signaling pathway.
Brain Neoplasms
The DNA-PK inhibitor VX-984 enhances the radiosensitivity of glioblastoma cells grown in vitro and as orthotopic xenografts.
Brain Stem Neoplasms
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
Breast Diseases
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling.
Breast Diseases
Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells.
Breast Diseases
Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA.
Breast Diseases
Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.
Breast Neoplasms
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Breast Neoplasms
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling.
Breast Neoplasms
3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but akt-independent manner.
Breast Neoplasms
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Breast Neoplasms
4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis.
Breast Neoplasms
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
Breast Neoplasms
9-Hydroxypheophorbide alpha-induced apoptotic death of MCF-7 breast cancer cells is mediated by c-Jun N-terminal kinase activation.
Breast Neoplasms
A 20-year perspective on the International Fanconi Anemia Registry (IFAR).
Breast Neoplasms
A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.
Breast Neoplasms
A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.
Breast Neoplasms
A case of Peutz-Jeghers syndrome with breast cancer, bilateral sex cord tumor with annular tubules, and adenoma malignum caused by STK11 gene mutation.
Breast Neoplasms
A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer.
Breast Neoplasms
A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer.
Breast Neoplasms
A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ER?-positive breast cancer cells.
Breast Neoplasms
A Novel Approach for Overcoming Drug Resistance in Breast Cancer Chemotherapy by Targeting new Synthetic Curcumin Analogues Against Aldehyde Dehydrogenase 1 (ALDH1A1) and Glycogen Synthase Kinase-3 ? (GSK-3?).
Breast Neoplasms
A Novel Cancer Testis Antigen, A-Kinase Anchor Protein 4 (AKAP4) Is a Potential Biomarker for Breast Cancer.
Breast Neoplasms
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Breast Neoplasms
A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/?-catenin signaling in breast cancer.
Breast Neoplasms
A novel PAK4-CEBPB-CLDN4 axis involving in breast cancer cell migration and invasion.
Breast Neoplasms
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines.
Breast Neoplasms
A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls.
Breast Neoplasms
A study of over 35,000 women with breast cancer tested with a 25-gene panel of hereditary cancer genes.
Breast Neoplasms
A systematic review of the prevalence of DNA damage response gene mutations in prostate cancer.
Breast Neoplasms
A vector-based short hairpin RNA targeting Aurora A inhibits breast cancer growth.
Breast Neoplasms
A-kinase anchor protein 12 (AKAP12) inhibits cell migration in breast cancer.
Breast Neoplasms
A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.
Breast Neoplasms
Aberrant methylation profile of 14-3-3 sigma and its reduced transcription/expression levels in Chinese sporadic female breast carcinogenesis.
Breast Neoplasms
Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer.
Breast Neoplasms
Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients.
Breast Neoplasms
Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats.
Breast Neoplasms
Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
Breast Neoplasms
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.
Breast Neoplasms
Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variables.
Breast Neoplasms
Adenovirus-mediated Aurora A shRNA driven by stathmin promoter suppressed tumor growth and enhanced paclitaxel chemotherapy sensitivity in human breast carcinoma cells.
Breast Neoplasms
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization.
Breast Neoplasms
Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers.
Breast Neoplasms
AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-?B signaling pathway.
Breast Neoplasms
Akt regulates RSK2 to alter phosphorylation level of H2A.X in breast cancer.
Breast Neoplasms
Akt-Induced Tamoxifen Resistance is Associated with Altered FKHR Regulation.
Breast Neoplasms
AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation.
Breast Neoplasms
Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.
Breast Neoplasms
Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
Breast Neoplasms
Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth.
Breast Neoplasms
Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: antiestrogen selectivity and promoter dependence.
Breast Neoplasms
Alterations of microRNAs are associated with impaired growth of MCF-7 breast cancer cells induced by inhibition of casein kinase 2.
Breast Neoplasms
Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.
Breast Neoplasms
An evaluation of prognostic value of death-associated protein kinase 1 in breast cancer.
Breast Neoplasms
An In Vivo Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid.
Breast Neoplasms
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.
Breast Neoplasms
Analysis of Cell-type Specific Expression of CK1{varepsilon} in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag Transgenic Mice.
Breast Neoplasms
Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer.
Breast Neoplasms
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter.
Breast Neoplasms
Androgen stimulates mitogen-activated protein kinase in human breast cancer cells.
Breast Neoplasms
Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway.
Breast Neoplasms
Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells.
Breast Neoplasms
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Breast Neoplasms
Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha.
Breast Neoplasms
Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk.
Breast Neoplasms
Antiproliferative effects of selective cyclooxygenase-2 inhibitor modulated by nimotuzumab in estrogen-dependent breast cancer cells.
Breast Neoplasms
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Breast Neoplasms
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Breast Neoplasms
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.
Breast Neoplasms
Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.
Breast Neoplasms
Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.
Breast Neoplasms
Are polymorphisms of the ataxia telangiectasia mutated gene associated with breast cancer risk?
Breast Neoplasms
Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?
Breast Neoplasms
Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.
Breast Neoplasms
Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females.
Breast Neoplasms
Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients.
Breast Neoplasms
Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies.
Breast Neoplasms
Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.
Breast Neoplasms
Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast cancer cells.
Breast Neoplasms
Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression.
Breast Neoplasms
Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients.
Breast Neoplasms
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.
Breast Neoplasms
ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency.
Breast Neoplasms
Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.
Breast Neoplasms
ATM kinase regulates tumor immunoreactions in lymphocyte-predominant breast cancer through modulation of NKG2D ligand and TNF cytokines on tumor cells.
Breast Neoplasms
ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations.
Breast Neoplasms
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.
Breast Neoplasms
Attenuation of ERK/RSK2-Driven NF?B Gene Expression and Cancer Cell Proliferation by Kurarinone, a Lavandulyl Flavanone Isolated from Sophora flavescens Ait. Roots.
Breast Neoplasms
Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer.
Breast Neoplasms
Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.
Breast Neoplasms
Aurora A overexpression in breast cancer patients induces taxane resistance and results in worse prognosis.
Breast Neoplasms
Aurora B induces epithelial-mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis.
Breast Neoplasms
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer.
Breast Neoplasms
Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ER? expression in initially ER?+ breast cancer cells.
Breast Neoplasms
Autocrine signalling through erbB receptors promotes constitutive activation of protein kinase B/Akt in breast cancer cell lines.
Breast Neoplasms
BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase.
Breast Neoplasms
Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression.
Breast Neoplasms
BMP-2 upregulates the AKT/mTOR pathway in breast cancer with microcalcification and indicates a poor prognosis.
Breast Neoplasms
Body fatness and mTOR pathway activation of breast cancer in the Women's Circle of Health Study.
Breast Neoplasms
Breast Cancer Cells Proliferation Is Regulated by Tyrosine Phosphatase SHP1 through c-jun N-Terminal Kinase and Cooperative Induction of RFX-1 and AP-4 Transcription Factors.
Breast Neoplasms
Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status.
Breast Neoplasms
Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer.
Breast Neoplasms
Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.
Breast Neoplasms
Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.
Breast Neoplasms
Breast cancer susceptibility: current knowledge and implications for genetic counselling.
Breast Neoplasms
Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.
Breast Neoplasms
Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology.
Breast Neoplasms
BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation.
Breast Neoplasms
Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.
Breast Neoplasms
C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer.
Breast Neoplasms
c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.
Breast Neoplasms
c-Jun N-terminal kinase inactivation by mitogen-activated protein kinase phosphatase 1 determines resistance to taxanes and anthracyclines in breast cancer.
Breast Neoplasms
c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.
Breast Neoplasms
C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer.
Breast Neoplasms
Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers.
Breast Neoplasms
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
Breast Neoplasms
Cantharidin Induces DNA Damage and Inhibits DNA Repair-associated Protein Expressions in TSGH8301 Human Bladder Cancer Cell.
Breast Neoplasms
Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells.
Breast Neoplasms
Casein kinase 1? promotes cell proliferation by regulating mRNA translation.
Breast Neoplasms
Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines.
Breast Neoplasms
Casein kinase I epsilon somatic mutations found in breast cancer cause overgrowth in Drosophila.
Breast Neoplasms
Caspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3? pathway in vivo and in vitro.
Breast Neoplasms
Casticin inhibits breast cancer cell migration and invasion by down-regulation of PI3K/Akt signaling pathway.
Breast Neoplasms
CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.
Breast Neoplasms
Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours.
Breast Neoplasms
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Breast Neoplasms
CG0009, a novel glycogen synthase kinase 3 inhibitor, induces cell death through cyclin D1 depletion in breast cancer cells.
Breast Neoplasms
Changes in messenger RNA expression of protein kinase A regulatory subunit ialpha in breast cancer patients treated with tamoxifen.
Breast Neoplasms
Characterization and hormonal regulation of casein kinase II activity in heterotransplanted human breast tumors in nude mice.
Breast Neoplasms
Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer.
Breast Neoplasms
Characterization of the expression and prognostic value of 14-3-3 isoforms in breast cancer.
Breast Neoplasms
Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients.
Breast Neoplasms
Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer.
Breast Neoplasms
Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer.
Breast Neoplasms
Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819.
Breast Neoplasms
Chk1 suppression leads to a reduction in the enhanced radiation-induced invasive capability on breast cancer cells.
Breast Neoplasms
Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells.
Breast Neoplasms
Circular RNA VRK1 correlates with favourable prognosis, inhibits cell proliferation but promotes apoptosis in breast cancer.
Breast Neoplasms
CK1epsilon is required for breast cancers dependent on beta-catenin activity.
Breast Neoplasms
CK1{delta} modulates the transcriptional activity of ER{alpha} via AIB1 in an estrogen-dependent manner and regulates ER{alpha}-AIB1 interactions.
Breast Neoplasms
Clinical and biological significance of GSK-3beta inactivation in breast cancer-an immunohistochemical study.
Breast Neoplasms
Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.
Breast Neoplasms
Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer.
Breast Neoplasms
Clinical Implications of the Progression-Free Survival Endpoint for Treatment of Hormone Receptor-Positive Advanced Breast Cancer.
Breast Neoplasms
Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies.
Breast Neoplasms
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Breast Neoplasms
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.
Breast Neoplasms
Co-treatment of LY294002 or MK-2206 with AZD5363 Attenuates AZD5363-induced Increase in the Level of Phosphorylated AKT.
Breast Neoplasms
Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells.
Breast Neoplasms
Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110? Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers.
Breast Neoplasms
Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer.
Breast Neoplasms
Combined bazedoxifene and paclitaxel treatments inhibit cell viability, cell migration, colony formation, and tumor growth and induce apoptosis in breast cancer.
Breast Neoplasms
Combined effect of papuamine and doxorubicin in human breast cancer MCF-7 cells.
Breast Neoplasms
Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer.
Breast Neoplasms
Combined LIM kinase 1 and p21-Activated kinase 4 inhibitor treatment exhibits potent preclinical antitumor efficacy in breast cancer.
Breast Neoplasms
Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth.
Breast Neoplasms
Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.
Breast Neoplasms
Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.
Breast Neoplasms
Comparison of Anticancer Activity of Dorycnium pentaphyllum Extract on MCF-7 and MCF-12A Cell Line: Correlation with Invasion and Adhesion.
Breast Neoplasms
Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic Outcomes.
Breast Neoplasms
Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.
Breast Neoplasms
Computational algorithms for in silico profiling of activating mutations in cancer.
Breast Neoplasms
Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.
Breast Neoplasms
Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis.
Breast Neoplasms
Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer.
Breast Neoplasms
Contribution of protein kinase A and protein kinase C signalling pathways to the regulation of HSD11B2 expression and proliferation of MCF-7 cells.
Breast Neoplasms
Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.
Breast Neoplasms
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.
Breast Neoplasms
Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth.
Breast Neoplasms
Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer.
Breast Neoplasms
COP1 and GSK3? Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis.
Breast Neoplasms
Correlation of epidermal growth factor receptor (EGFR), androgen receptor (AR) and 14-3-3 sigma expression in breast cancer.
Breast Neoplasms
Correlation of expression of WWOX and JNK with clinicopathologic features in human breast carcinoma.
Breast Neoplasms
Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.
Breast Neoplasms
Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation.
Breast Neoplasms
CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.
Breast Neoplasms
Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells.
Breast Neoplasms
Curcumin Rescues Doxorubicin Responsiveness via Regulating Aurora a Signaling Network in Breast Cancer Cells.
Breast Neoplasms
Curcumin Triggers DNA Damage and Inhibits Expression of DNA Repair Proteins in Human Lung Cancer Cells.
Breast Neoplasms
Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers.
Breast Neoplasms
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Breast Neoplasms
Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer.
Breast Neoplasms
D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells.
Breast Neoplasms
Danthron Induces DNA Damage and Inhibits DNA Repair Gene Expressions in GBM 8401 Human Brain Glioblastoma Multiforms Cells.
Breast Neoplasms
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Breast Neoplasms
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
Breast Neoplasms
Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.
Breast Neoplasms
Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer.
Breast Neoplasms
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Breast Neoplasms
Delivery of Protein Kinase A by CRISPRMAX and Its Effects on Breast Cancer Stem-Like Properties.
Breast Neoplasms
Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition.
Breast Neoplasms
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Breast Neoplasms
Detailed chromosomal characterization of the breast cancer cell line MCF7 with special focus on the expression of the serine-threonine kinase 15.
Breast Neoplasms
Detection of 14-3-3 sigma (?) promoter methylation as a noninvasive biomarker using blood samples for breast cancer diagnosis.
Breast Neoplasms
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Breast Neoplasms
Development of dual casein kinase 1?/1? (CK1?/?) inhibitors for treatment of breast cancer.
Breast Neoplasms
Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors.
Breast Neoplasms
DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway.
Breast Neoplasms
Differential gene expression profile of retinoblastoma compared to normal retina.
Breast Neoplasms
Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin.
Breast Neoplasms
Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation.
Breast Neoplasms
Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer.
Breast Neoplasms
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.
Breast Neoplasms
DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.
Breast Neoplasms
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Breast Neoplasms
DOK7 Inhibits Cell Proliferation, Migration, and Invasion of Breast Cancer via the PI3K/PTEN/AKT Pathway.
Breast Neoplasms
Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing.
Breast Neoplasms
Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer.
Breast Neoplasms
Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells.
Breast Neoplasms
Downregulation of 14-3-3? inhibits proliferation and migration in osteosarcoma cells.
Breast Neoplasms
Downregulation of MicroRNA-152 and Inhibition of Cell Proliferation, Migration, and Invasion in Breast Cancer.
Breast Neoplasms
Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation.
Breast Neoplasms
Effect of NUCKS-1 overexpression on cytokine profiling in obese women with breast cancer.
Breast Neoplasms
Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
Breast Neoplasms
Effective Targeting of Raf-1 and Its Associated Autophagy by Novel Extracted Peptide for Treating Breast Cancer Cells.
Breast Neoplasms
Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer.
Breast Neoplasms
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer.
Breast Neoplasms
Effects of the activated mitogen-activated protein kinase pathway via the c-ros receptor tyrosine kinase on the T47D breast cancer cell line following alcohol exposure.
Breast Neoplasms
Effects of the novel DNA dependent protein kinase inhibitor, IC486241, on the DNA damage response to doxorubicin and cisplatin in breast cancer cells.
Breast Neoplasms
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Breast Neoplasms
EGFR and ErbB2 differentially regulate Raf-1 translocation and activation.
Breast Neoplasms
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Breast Neoplasms
Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.
Breast Neoplasms
Enhanced effect of geldanamycin nanocomposite against breast cancer cells growing in vitro and as xenograft with vanquished normal cell toxicity.
Breast Neoplasms
Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
Breast Neoplasms
Epigenetic alterations by methylation of RASSF1A and DAPK1 promoter sequences in mammary carcinoma detected in extracellular tumor DNA.
Breast Neoplasms
Erratum: Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.
Breast Neoplasms
Erratum: Zare, A. et al. RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis. Cancers, 2018, 10, 184.
Breast Neoplasms
ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells.
Breast Neoplasms
Estradiol promotes the progression of ER+ breast cancer through methylation-mediated RSK4 inactivation.
Breast Neoplasms
Estradiol suppresses phosphorylation of ER? serine 167 through upregulation of PP2A in breast cancer cells.
Breast Neoplasms
Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells.
Breast Neoplasms
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements.
Breast Neoplasms
Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians.
Breast Neoplasms
Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer.
Breast Neoplasms
Exceptional durable response to everolimus in a patient with biphenotypic breast cancer harboring an STK11 variant.
Breast Neoplasms
Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer.
Breast Neoplasms
Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
Breast Neoplasms
Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo.
Breast Neoplasms
Expression of DNA-PKcs and BRCA1 as prognostic indicators in nasopharyngeal carcinoma following intensity-modulated radiation therapy.
Breast Neoplasms
Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney.
Breast Neoplasms
Exquisite antitumour response to trastuzumab in a patient with no evidence of Ras-Raf-MAPK and PI3K-Akt pathways activation.
Breast Neoplasms
Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer.
Breast Neoplasms
FADD phosphorylation is critical for cell cycle regulation in breast cancer cells.
Breast Neoplasms
Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells.
Breast Neoplasms
Focal adhesion kinase and protein kinase B cooperate to suppress Doxorubicin-induced apoptosis of breast tumor cells.
Breast Neoplasms
Formation of tissue factor-factor VIIa-factor Xa complex induces activation of the mTOR pathway which regulates migration of human breast cancer cells.
Breast Neoplasms
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Breast Neoplasms
Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families.
Breast Neoplasms
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Breast Neoplasms
Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.
Breast Neoplasms
Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.
Breast Neoplasms
Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.
Breast Neoplasms
Functional proteomics of breast cancer for signal pathway profiling and target discovery.
Breast Neoplasms
Functional significance of Aurora kinase A regulatory interactions with p53-ER? complex in human breast cancer cells.
Breast Neoplasms
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Breast Neoplasms
G-Protein-Coupled Receptor 5 (LGR5) Overexpression Activates ?-Catenin Signaling in Breast Cancer Cells via Protein Kinase A.
Breast Neoplasms
Gallic acid induces DNA damage and inhibits DNA repair-associated protein expression in human oral cancer SCC-4 cells.
Breast Neoplasms
Gene analysis techniques and susceptibility gene discovery in non-BRCA1/BRCA2 familial breast cancer.
Breast Neoplasms
Gene expression profile by inhibiting Raf-1 protein kinase in breast cancer cells.
Breast Neoplasms
Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk.
Breast Neoplasms
Genetic testing for hereditary prostate cancer: Current status and limitations.
Breast Neoplasms
Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.
Breast Neoplasms
Germline PALB2, ATM variants in a patient with breast and ovarian cancer at risk for familial cancer syndrome: Is there a role for risk-reducing salpingo-oophorectomy?
Breast Neoplasms
Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor.
Breast Neoplasms
Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.
Breast Neoplasms
GPR30 expression and function in breast cancer cells are induced through a cis?acting element targeted by ETS factors.
Breast Neoplasms
Growth inhibition and antimetastatic effect of antisense poly-DNP-RNA on human breast cancer cells.
Breast Neoplasms
Growth inhibition by 8-chloro cyclic AMP of human HT29 colorectal and ZR-75-1 breast carcinoma xenografts is associated with selective modulation of protein kinase A isoenzymes.
Breast Neoplasms
Growth signaling in breast cancer cells: outcomes and promises of proteomics.
Breast Neoplasms
GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals.
Breast Neoplasms
Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells.
Breast Neoplasms
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells.
Breast Neoplasms
Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in two of the most relevant gynaecological tumor entities.
Breast Neoplasms
HER-2 Expression Correlates with Survivin in Primary Invasive Ductal Breast Cancers.
Breast Neoplasms
Hereditary breast cancer: high risk genes, genetic testing and clinical implications.
Breast Neoplasms
Hereditary breast cancer: new genetic developments, new therapeutic avenues.
Breast Neoplasms
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
Breast Neoplasms
Heregulin-?1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways.
Breast Neoplasms
High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer.
Breast Neoplasms
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
Breast Neoplasms
High Raf-1 kinase activity protects human tumor cells against paclitaxel-induced cytotoxicity.
Breast Neoplasms
High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.
Breast Neoplasms
Higher serum concentrations of vimentin and DAKP1 are associated with aggressive breast tumour phenotypes in Ghanaian women.
Breast Neoplasms
Histopathological features of breast cancer in carriers of ATM gene variants.
Breast Neoplasms
Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells.
Breast Neoplasms
Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells.
Breast Neoplasms
Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.
Breast Neoplasms
Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells.
Breast Neoplasms
Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.
Breast Neoplasms
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms.
Breast Neoplasms
Hypoxia regulation of phosphokinases and the prognostic value of pAKT in breast cancer.
Breast Neoplasms
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.
Breast Neoplasms
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Breast Neoplasms
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Breast Neoplasms
Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells.
Breast Neoplasms
Identification of Aurora Kinase A as a Biomarker for Prognosis in Obesity Patients with Early Breast Cancer.
Breast Neoplasms
Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer.
Breast Neoplasms
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.
Breast Neoplasms
Identification of key genes in glioblastoma-associated stromal cells using bioinformatics analysis.
Breast Neoplasms
Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration.
Breast Neoplasms
Identification of the potential roles of ring finger protein 8 in TP53-mutant breast cancer.
Breast Neoplasms
Identifying breast cancer subtypes associated modules and biomarkers by integrated bioinformatics analysis.
Breast Neoplasms
IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells.
Breast Neoplasms
IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells.
Breast Neoplasms
Immuno-Affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance.
Breast Neoplasms
Immunohistochemical Detection of Phospho-Akt, Phospho-BAD, HER2 and Oestrogen Receptors alpha and beta in Malaysian Breast Cancer Patients.
Breast Neoplasms
Immunohistochemical evaluation of ROCK activation in invasive breast cancer.
Breast Neoplasms
Impaired DNA Repair Fidelity in a Breast Cancer Patient With Adverse Reactions to Radiotherapy.
Breast Neoplasms
Implication of Integrin ?2?1 in Proliferation and Invasion of Human Breast Carcinoma and Melanoma Cells: Noncanonical Function of Akt Protein Kinase.
Breast Neoplasms
Improved ataxia telangiectasia mutated kinase inhibitor KU60019 provides a promising treatment strategy for non-invasive breast cancer.
Breast Neoplasms
In vivo and in vitro impact of miRNA-153 on the suppression of cell growth apoptosis through mTORC2 signaling pathway in breast cancer.
Breast Neoplasms
Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.
Breast Neoplasms
Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line.
Breast Neoplasms
Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells.
Breast Neoplasms
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.
Breast Neoplasms
Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.
Breast Neoplasms
Induction of ErbB-3 Expression by alpha6beta4 Integrin Contributes to Tamoxifen Resistance in ERbeta1-Negative Breast Carcinomas.
Breast Neoplasms
Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells.
Breast Neoplasms
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells.
Breast Neoplasms
Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT.
Breast Neoplasms
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Breast Neoplasms
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Breast Neoplasms
Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of ?1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.
Breast Neoplasms
Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells.
Breast Neoplasms
Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.
Breast Neoplasms
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Breast Neoplasms
Integration of Downstream Signals of Insulin-like Growth Factor-1 Receptor by Endoplasmic Reticulum Stress for Estrogen-Induced Growth or Apoptosis in Breast Cancer Cells.
Breast Neoplasms
Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.
Breast Neoplasms
Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells.
Breast Neoplasms
Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells.
Breast Neoplasms
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy.
Breast Neoplasms
Involvement of nuclear steroid/thyroid/retinoid receptors and of protein kinases in the regulation of growth and of c-erbB and retinoic acid receptor expression in MCF-7 breast cancer cells.
Breast Neoplasms
Is it possible to extract a fingerprint for early breast cancer via EEG analysis?
Breast Neoplasms
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
Breast Neoplasms
Jolkinolide B inhibits proliferation or migration and promotes apoptosis of MCF-7 or BT-474 breast cancer cells by downregulating the PI3K-Akt pathway.
Breast Neoplasms
Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer.
Breast Neoplasms
Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis.
Breast Neoplasms
KiSS1-induced GPR54 signaling inhibits breast cancer cell migration and epithelial-mesenchymal transition via protein kinase D1.
Breast Neoplasms
Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo.
Breast Neoplasms
Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGF?/CTGF Axis.
Breast Neoplasms
L-A03, a dihydroartemisinin derivative, promotes apoptotic cell death of human breast cancer MCF-7 cells by targeting c-Jun N-terminal kinase.
Breast Neoplasms
Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.
Breast Neoplasms
Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells.
Breast Neoplasms
LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
Breast Neoplasms
Liver Kinase B1-A Potential Therapeutic Target in Hormone-Sensitive Breast Cancer in Older Women.
Breast Neoplasms
LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors.
Breast Neoplasms
Long non-coding RNA PTENP1 inhibits proliferation and migration of breast cancer cells via AKT and MAPK signaling pathways.
Breast Neoplasms
Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer.
Breast Neoplasms
Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb) in human breast carcinoma cells.
Breast Neoplasms
Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment.
Breast Neoplasms
MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
Breast Neoplasms
Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells.
Breast Neoplasms
MCPH1 protein expression and polymorphisms are associated with risk of breast cancer.
Breast Neoplasms
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.
Breast Neoplasms
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Breast Neoplasms
microRNA-133a regulates the cell cycle and proliferation of breast cancer cells by targeting epidermal growth factor receptor through the EGFR/Akt signaling pathway.
Breast Neoplasms
MicroRNA-145 inhibits growth and migration of breast cancer cells through targeting oncoprotein ROCK1.
Breast Neoplasms
microRNA-152 inhibits cell proliferation, migration and invasion in breast cancer.
Breast Neoplasms
MicroRNA-204 inhibits the proliferation and metastasis of breast cancer cells by targeting PI3K/AKT pathway.
Breast Neoplasms
MicroRNA-215 acts as a tumor suppressor in breast cancer by targeting AKT serine/threonine kinase 1.
Breast Neoplasms
MicroRNA-340 inhibits invasion and metastasis by downregulating ROCK1 in breast cancer cells.
Breast Neoplasms
MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway.
Breast Neoplasms
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions.
Breast Neoplasms
MicroRNA?299?5p inhibits cell metastasis in breast cancer by directly targeting serine/threonine kinase 39.
Breast Neoplasms
Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target.
Breast Neoplasms
MiR-202 inhibits cell proliferation, invasion, and migration in breast cancer by targeting ROCK1 gene.
Breast Neoplasms
MiR-216a-5p act as a tumor suppressor, regulating the cell proliferation and metastasis by targeting PAK2 in breast cancer.
Breast Neoplasms
MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1.
Breast Neoplasms
miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.
Breast Neoplasms
Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents.
Breast Neoplasms
Mitotic kinases as drivers of the epithelial-to-mesenchymal transition and as therapeutic targets against breast cancers.
Breast Neoplasms
MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells.
Breast Neoplasms
Molecular Mechanism of Secondary Endocrine Resistance in Luminal Breast Cancer.
Breast Neoplasms
Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells.
Breast Neoplasms
Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family.
Breast Neoplasms
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.
Breast Neoplasms
MRCK? Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
Breast Neoplasms
MUC1-C oncoprotein induces tamoxifen resistance in human breast cancer cells.
Breast Neoplasms
MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells.
Breast Neoplasms
Multistage Vectored siRNA Targeting Ataxia-Telangiectasia Mutated for Breast Cancer Therapy.
Breast Neoplasms
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Breast Neoplasms
Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.
Breast Neoplasms
New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.
Breast Neoplasms
No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer.
Breast Neoplasms
Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines.
Breast Neoplasms
Non-BRCA1/2 Breast Cancer Susceptibility Genes: A New Frontier with Clinical Consequences for Plastic Surgeons.
Breast Neoplasms
Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism.
Breast Neoplasms
Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.
Breast Neoplasms
Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.
Breast Neoplasms
Novel actions of tyrphostin AG 879: inhibition of RAF-1 and HER-2 expression combined with strong antitumoral effects on breast cancer cells.
Breast Neoplasms
Novel germline STK11 variants and breast cancer phenotype identified in an Indian cohort of Peutz-Jeghers syndrome.
Breast Neoplasms
Novel interacting proteins identified by tandem affinity purification coupled to nano LC-MS/MS interact with ribosomal S6 protein kinase 4 (RSK4) and its variant protein (RSK4m).
Breast Neoplasms
Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells.
Breast Neoplasms
Nucleus-located PDK1 regulates growth, invasion and migration of breast cancer cells.
Breast Neoplasms
Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells.
Breast Neoplasms
Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.
Breast Neoplasms
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer.
Breast Neoplasms
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Breast Neoplasms
Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor.
Breast Neoplasms
Overexpression of AKIP1 predicts poor prognosis of patients with breast carcinoma and promotes cancer metastasis through Akt/GSK-3?/Snail pathway.
Breast Neoplasms
Overexpression of cyclo-oxygenase-2 is an independent predictor of unfavourable outcome in node-negative breast cancer, but is not associated with protein kinase B (Akt) and mitogen-activated protein kinase (ERK1/2, p38) activation or with Her-2/neu signalling pathways.
Breast Neoplasms
Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients.
Breast Neoplasms
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Breast Neoplasms
Overexpression of Rho-Associated Coiled-Coil Containing Protein Kinase 2 Is Correlated with Clinical Progression and Poor Prognosis in Breast Cancer.
Breast Neoplasms
Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/Akt signaling pathway.
Breast Neoplasms
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells.
Breast Neoplasms
P21-activated kinase 4 regulates the cyclin-dependent kinase inhibitor p57(kip2) in human breast cancer.
Breast Neoplasms
P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.
Breast Neoplasms
Pak1 kinase links ErbB2 to ?-catenin in transformation of breast epithelial cells.
Breast Neoplasms
PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.
Breast Neoplasms
PAK1 translocates into nucleus in response to prolactin but not to estrogen.
Breast Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Breast Neoplasms
PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase, a Putative Cancer/Testis Antigen with an Oncogenic Activity in Breast Cancer.
Breast Neoplasms
PET Imaging on Dynamic Metabolic Changes after Combination Therapy of Paclitaxel and the Traditional Chinese Medicine in Breast Cancer-Bearing Mice.
Breast Neoplasms
PFKFB3 is involved in breast cancer proliferation, migration, invasion and angiogenesis.
Breast Neoplasms
Phase I trial to evaluate the addition of alisertib to fulvestrant in women with endocrine-resistant, ER+ metastatic breast cancer.
Breast Neoplasms
Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling.
Breast Neoplasms
Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity.
Breast Neoplasms
Phenotypic analysis of familial breast cancer: Comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.
Breast Neoplasms
Phenotypic differentiation of human breast cancer cells by 1,3 cyclic propanediol phosphate.
Breast Neoplasms
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
Breast Neoplasms
Phosphorylated Akt1 in human breast cancer measured by direct sandwich enzyme-linked immunosorbent assay: Correlation with clinicopathological features and tumor VEGF-signaling system component levels.
Breast Neoplasms
Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.
Breast Neoplasms
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells.
Breast Neoplasms
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
Breast Neoplasms
Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells.
Breast Neoplasms
Phosphorylation stabilizes alternatively spliced CD44 mRNA transcripts in breast cancer cells: inhibition by antisense complementary to casein kinase II mRNA.
Breast Neoplasms
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects.
Breast Neoplasms
PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer: a novel regulation of estrogen receptor expression.
Breast Neoplasms
Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin.
Breast Neoplasms
Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer.
Breast Neoplasms
Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression.
Breast Neoplasms
Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells.
Breast Neoplasms
PKA phosphorylation redirects ER? to promoters of a unique gene set to induce tamoxifen resistance.
Breast Neoplasms
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest.
Breast Neoplasms
PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression.
Breast Neoplasms
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.
Breast Neoplasms
Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia.
Breast Neoplasms
Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells.
Breast Neoplasms
Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer.
Breast Neoplasms
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Breast Neoplasms
Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization.
Breast Neoplasms
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.
Breast Neoplasms
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival.
Breast Neoplasms
Prepubertal genistein exposure affects erbB2/Akt signal and reduces rat mammary tumorigenesis.
Breast Neoplasms
Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.
Breast Neoplasms
Pro-necrotic molecules impact local immunosurveillance in human breast cancer.
Breast Neoplasms
Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency.
Breast Neoplasms
Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells.
Breast Neoplasms
Prognostic and predictive value of p-Akt, EGFR, and p-mTOR in early breast cancer.
Breast Neoplasms
Prospecting for Breast Cancer Blood Biomarkers: Death-Associated Protein Kinase 1 (DAPK1) as a Potential Candidate.
Breast Neoplasms
Protein kinase A activation by ??Lapachone is associated with apoptotic cell death in NQO1?overexpressing breast cancer cells.
Breast Neoplasms
Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines.
Breast Neoplasms
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration.
Breast Neoplasms
Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation.
Breast Neoplasms
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Breast Neoplasms
Protein kinase C ? enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.
Breast Neoplasms
Protein Kinase CK2 Expression Predicts Relapse Survival in ER? Dependent Breast Cancer, and Modulates ER? Expression in Vitro.
Breast Neoplasms
Protein kinase CK2 in breast cancer: the CK2? regulatory subunit takes center stage in epithelial plasticity.
Breast Neoplasms
Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells.
Breast Neoplasms
Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells.
Breast Neoplasms
Protein kinase D1 inhibits breast cancer cell invasion via regulating matrix metalloproteinase expression.
Breast Neoplasms
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
Breast Neoplasms
Protein kinase D1 regulates ER?-positive breast cancer cell growth response to 17?-estradiol and contributes to poor prognosis in patients.
Breast Neoplasms
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.
Breast Neoplasms
Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway.
Breast Neoplasms
Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.
Breast Neoplasms
Proteomic analysis of ductal carcinoma of the breast using laser capture microdissection, LC-MS, and 16O/18O isotopic labeling.
Breast Neoplasms
Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach.
Breast Neoplasms
Proteomic analysis reveals that 14-3-3sigma is down-regulated in human breast cancer cells.
Breast Neoplasms
Proteomic Changes Induced by Effective Chemopreventive Ratios of n-3:n-6 Fatty Acids and Tamoxifen against MNU-Induced Mammary Cancer in the Rat.
Breast Neoplasms
Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID?
Breast Neoplasms
Proteomics of breast cancer for marker discovery and signal pathway profiling.
Breast Neoplasms
Proteomics-derived basal biomarker DNA-PKcs is associated with intrinsic subtype and long-term clinical outcomes in breast cancer.
Breast Neoplasms
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Breast Neoplasms
PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation.
Breast Neoplasms
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.
Breast Neoplasms
PTH-related protein upregulates integrin alpha6beta4 expression and activates Akt in breast cancer cells.
Breast Neoplasms
QLT0267, a small molecule inhibitor targeting Integrin-Linked Kinase (ILK), and Docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model.
Breast Neoplasms
Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin via PTEN/Akt Pathway.
Breast Neoplasms
Quinazolino linked 4?-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation.
Breast Neoplasms
Radiographic Surveillance of Patients with Non-BRCA1/2 Pathogenic Variants.
Breast Neoplasms
Raf kinase inhibitory protein role in the molecular subtyping of breast cancer.
Breast Neoplasms
Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance.
Breast Neoplasms
Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells.
Breast Neoplasms
Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients.
Breast Neoplasms
Recommendations for Preventive Care for Women with Rare Genetic Cause of Breast and Ovarian Cancer.
Breast Neoplasms
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition.
Breast Neoplasms
Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen.
Breast Neoplasms
Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis.
Breast Neoplasms
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
Breast Neoplasms
Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function.
Breast Neoplasms
Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.
Breast Neoplasms
Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices.
Breast Neoplasms
Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3? signaling pathway.
Breast Neoplasms
Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.
Breast Neoplasms
Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling.
Breast Neoplasms
Retinoids increase cell-cell adhesion strength, beta-catenin protein stability, and localization to the cell membrane in a breast cancer cell line: a role for serine kinase activity.
Breast Neoplasms
Retraction: Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells.
Breast Neoplasms
Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels.
Breast Neoplasms
RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
Breast Neoplasms
RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis.
Breast Neoplasms
ROCK1 Inhibition Promotes the Self-Renewal of a Novel Mouse Mammary Cancer Stem Cell.
Breast Neoplasms
Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.
Breast Neoplasms
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Breast Neoplasms
Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells.
Breast Neoplasms
Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases.
Breast Neoplasms
Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair.
Breast Neoplasms
Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells.
Breast Neoplasms
Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer.
Breast Neoplasms
Roscovitine and Trichostatin A promote DNA damage repair during porcine oocyte maturation.
Breast Neoplasms
RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer.
Breast Neoplasms
Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.
Breast Neoplasms
San Huang Decoction downregulates Aurora kinase A to inhibit breast cancer cell growth and enhance chemosenstivity to anti-tumor drugs.
Breast Neoplasms
Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
Breast Neoplasms
Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.
Breast Neoplasms
Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.
Breast Neoplasms
Selective modulation of protein kinase A and protein kinase C activities in epidermal growth factor (EGF)-stimulated MCF-7 breast cancer cells.
Breast Neoplasms
Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.
Breast Neoplasms
Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
Breast Neoplasms
Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
Breast Neoplasms
Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways.
Breast Neoplasms
Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells.
Breast Neoplasms
Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway.
Breast Neoplasms
SIRT1 promotes formation of breast cancer through modulating Akt activity.
Breast Neoplasms
Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway.
Breast Neoplasms
Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
Breast Neoplasms
Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis.
Breast Neoplasms
Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance.
Breast Neoplasms
Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.
Breast Neoplasms
Stimulation or endothelin-1 secretion by human breast cancer cells through protein kinase A activation: a possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2.
Breast Neoplasms
STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy.
Breast Neoplasms
STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation.
Breast Neoplasms
Structure meets function--centrosomes, genome maintenance and the DNA damage response.
Breast Neoplasms
Study of promoter methylation pattern of 14-3-3 sigma gene in normal and cancerous tissue of breast: A potential biomarker for detection of breast cancer in patients.
Breast Neoplasms
Study on correlation between PKIB and pAkt expression in breast cancer tissues.
Breast Neoplasms
Synergistic activation of ER? by estrogen and prolactin in breast cancer cells requires tyrosyl phosphorylation of PAK1.
Breast Neoplasms
Synergistic Interactions of 5-Fluorouracil with Inhibitors of Protein Kinase CK2 Correlate with p38 MAPK Activation and FAK Inhibition in the Triple-Negative Breast Cancer Cell Line.
Breast Neoplasms
Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function.
Breast Neoplasms
Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.
Breast Neoplasms
Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells.
Breast Neoplasms
Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.
Breast Neoplasms
Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines.
Breast Neoplasms
Targeting dna double strand break repair with hyperthermia and dna-pkcs inhibition to enhance the effect of radiation treatment.
Breast Neoplasms
Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.
Breast Neoplasms
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Breast Neoplasms
Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.
Breast Neoplasms
Targeting the PI3K/Akt/mTOR-pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases.
Breast Neoplasms
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence.
Breast Neoplasms
The ?-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling.
Breast Neoplasms
The Ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants.
Breast Neoplasms
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.
Breast Neoplasms
The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.
Breast Neoplasms
The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.
Breast Neoplasms
The dual PI3K/mTOR-pathway inhibitor GDC-0084 achieves antitumor activity in PIK3CA-mutant breast cancer brain metastases.
Breast Neoplasms
The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
Breast Neoplasms
The expression and prognosis of Emi1 and Skp2 in breast carcinoma: associated with PI3K/Akt pathway and cell proliferation.
Breast Neoplasms
The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.
Breast Neoplasms
The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer.
Breast Neoplasms
The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.
Breast Neoplasms
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.
Breast Neoplasms
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ER?(+) breast cancer cells.
Breast Neoplasms
The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.
Breast Neoplasms
The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.
Breast Neoplasms
The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells.
Breast Neoplasms
The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis.
Breast Neoplasms
The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas.
Breast Neoplasms
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.
Breast Neoplasms
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Breast Neoplasms
The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.
Breast Neoplasms
The role of protein kinase B (PKB) in modulating heat sensitivity in a human breast cancer cell line.
Breast Neoplasms
The Roles of 4?-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells.
Breast Neoplasms
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.
Breast Neoplasms
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.
Breast Neoplasms
Time Trends in Receipt of Germline Genetic Testing and Results for Women Diagnosed With Breast Cancer or Ovarian Cancer, 2012-2019.
Breast Neoplasms
Tissue-Specific Warburg Effect in Breast Cancer and Cancer-Associated Adipose Tissue-Relationship between AMPK and Glycolysis.
Breast Neoplasms
TM4SF4 and LRRK2 are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis.
Breast Neoplasms
TMEM17 promotes malignant progression of breast cancer via AKT/GSK3? signaling.
Breast Neoplasms
Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
Breast Neoplasms
Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes.
Breast Neoplasms
Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.
Breast Neoplasms
Tumour suppressor PTEN regulates cell cycle and protein kinase B/Akt pathway in breast cancer cells.
Breast Neoplasms
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.
Breast Neoplasms
Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer.
Breast Neoplasms
Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1.
Breast Neoplasms
Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.
Breast Neoplasms
Use of serological proteomic methods to find biomarkers associated with breast cancer.
Breast Neoplasms
Validation of a Phosphoprotein Array Assay for Characterization of Human Tyrosine Kinase Receptor Downstream Signaling in Breast Cancer.
Breast Neoplasms
Validation of the cell cycle G(2) delay assay in assessing ionizing radiation sensitivity and breast cancer risk.
Breast Neoplasms
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
Breast Neoplasms
Variation of ATM Gene Expression in Peripheral Blood Cells of Sporadic Breast Carcinomas in Iranian Patients.
Breast Neoplasms
Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1.
Breast Neoplasms
Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles.
Breast Neoplasms
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.
Breast Neoplasms
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.
Breast Neoplasms
YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells.
Breast Neoplasms
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
Breast Neoplasms
[Correlation of p38 mitogen-activated protein kinase signal transduction pathway to uPA expression in breast cancer]
Breast Neoplasms
[Implications of genetic risk factors in breast cancer: culprit genes and associated malignancies]
Breast Neoplasms
[miR-153-3p inhibits proliferation and migration of breast cancer cells via down-regulating ROCK1].
Bulbo-Spinal Atrophy, X-Linked
Association of spinal and bulbar muscular atrophy with myotonic dystrophy type 1.
Burkitt Lymphoma
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Burkitt Lymphoma
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1.
Burkitt Lymphoma
Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.
Burkitt Lymphoma
Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells.
Burkitt Lymphoma
Signal transduction pathways in Burkitt's lymphoma cell lines BL41 and DG75 with different sensitivity to doxorubicin.
Burkitt Lymphoma
[Expression of p-AKT and p-mTOR in pediatric Burkitt lymphoma and their correlation with prognosis].
Calcinosis
BMP-2 upregulates the AKT/mTOR pathway in breast cancer with microcalcification and indicates a poor prognosis.
Candidiasis
A case report of sinusoidal diffuse large B-cell lymphoma in a STK4 deficient patient.
Candidiasis
Candida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis.
Candidiasis
Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis.
Capsule Opacification
Effect of H-7 on Secondary Cataract After Phacoemulsification in the Live Rabbit Eye.
Carcinogenesis
14-3-3 Proteins Modulate the ETS Transcription Factor ETV1 in Prostate Cancer.
Carcinogenesis
14-3-3? regulates the proliferation of glioma cells through the GSK3?/?-catenin signaling pathway.
Carcinogenesis
6-Bromoindirubin-3'-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver.
Carcinogenesis
A Functional Copy-Number Variation in MAPKAPK2 Predicts Risk and Prognosis of Lung Cancer.
Carcinogenesis
A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.
Carcinogenesis
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Carcinogenesis
A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation.
Carcinogenesis
A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206.
Carcinogenesis
A-Kinase Anchoring Proteins 10 Expression in Relation to 2073A/G Polymorphism and Tumor Progression in Patients with Colorectal Cancer.
Carcinogenesis
Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.
Carcinogenesis
Aberrant methylation profile of 14-3-3 sigma and its reduced transcription/expression levels in Chinese sporadic female breast carcinogenesis.
Carcinogenesis
Ablation of AMPK-Related Kinase MPK38/MELK Leads to Male-Specific Obesity in Aged Mature Adult Mice.
Carcinogenesis
Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesis.
Carcinogenesis
Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study.
Carcinogenesis
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion.
Carcinogenesis
Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma.
Carcinogenesis
Activation of phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling and the consequent induction of transformation by overexpressed 14-3-3? protein require specific amino acids within 14-3-3? N-terminal variable region II.
Carcinogenesis
Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia.
Carcinogenesis
Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice.
Carcinogenesis
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization.
Carcinogenesis
Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.
Carcinogenesis
Advances in understanding the molecular underpinnings of adrenocortical tumors.
Carcinogenesis
Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl)nitrosamine-induced murine bladder cancer.
Carcinogenesis
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer.
Carcinogenesis
AMPKalpha2 Regulates Bladder Cancer Growth Through SKP2-mediated Degradation of p27.
Carcinogenesis
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Carcinogenesis
An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.
Carcinogenesis
Analysis and prediction of pathways in HeLa cells by integrating biological levels of organization with systems-biology approaches.
Carcinogenesis
Analysis of calcium-dependent protein kinase C isoforms in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Carcinogenesis
Analysis of signaling protein kinases in human colon or colorectal carcinomas.
Carcinogenesis
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Carcinogenesis
ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis.
Carcinogenesis
ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis.
Carcinogenesis
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis.
Carcinogenesis
Association of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer.
Carcinogenesis
ATM may be a protective factor in endometrial carcinogenesis with the progesterone pathway.
Carcinogenesis
Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia.
Carcinogenesis
Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers.
Carcinogenesis
Aurora A is essential for early embryonic development and tumor suppression.
Carcinogenesis
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Carcinogenesis
Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor.
Carcinogenesis
Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.
Carcinogenesis
Aurora kinases link chromosome segregation and cell division to cancer susceptibility.
Carcinogenesis
Aurora-A kinase: a novel target both for cellular immunotherapy and molecular target therapy against human leukemia.
Carcinogenesis
Aurora-A regulates autophagy through the Akt pathway in human prostate cancer.
Carcinogenesis
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.
Carcinogenesis
Biology of Aurora A kinase: Implications in cancer manifestation and therapy.
Carcinogenesis
c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.
Carcinogenesis
Cancer risk from low dose radiation in Ptch1+/- mice with inactive DNA repair systems: Therapeutic implications for medulloblastoma.
Carcinogenesis
Casein kinase 2 inhibitor CX-4945 elicits an anti-Warburg effects through the downregulation of TAp73 and inhibits gastric tumorigenesis.
Carcinogenesis
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Carcinogenesis
CDK11p58 inhibits ER?-positive breast cancer invasion by targeting integrin ?3 via the repression of ER? signaling.
Carcinogenesis
Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.
Carcinogenesis
Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.
Carcinogenesis
Characterization of proteins secreted by pancreatic cancer cells with anticancer drug treatment in vitro.
Carcinogenesis
Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients.
Carcinogenesis
Checkpoint Kinase 1 Is Overexpressed during HPV16-Induced Cervical Carcinogenesis.
Carcinogenesis
Chemically induced degradation of CK2 by proteolysis targeting chimeras based on a ubiquitin-proteasome pathway.
Carcinogenesis
Chemoprevention with Protein Kinase A RI{alpha} Antisense in DMBA-Mammary Carcinogenesis.
Carcinogenesis
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Carcinogenesis
CK2?/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
Carcinogenesis
Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.
Carcinogenesis
Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells.
Carcinogenesis
Co-Upregulation of 14-3-3? and P-Akt is Associated with Oncogenesis and Recurrence of Hepatocellular Carcinoma.
Carcinogenesis
Combined blockade of AKT/mTOR pathway inhibits growth of human hemangioma via downregulation of proliferating cell nuclear antigen.
Carcinogenesis
Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways.
Carcinogenesis
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Carcinogenesis
Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.
Carcinogenesis
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.
Carcinogenesis
Correlation between Aurora-A expression and the prognosis of cervical carcinoma patients.
Carcinogenesis
Correlation between homeodomain-interacting protein kinase 2 and apoptosis in cervical cancer.
Carcinogenesis
Correlation of epidermal growth factor receptor (EGFR), androgen receptor (AR) and 14-3-3 sigma expression in breast cancer.
Carcinogenesis
CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy.
Carcinogenesis
Crosstalk between GSK-3, c-Fos, NF?B and TNF-? signaling pathways play an ambitious role in Chitosan Nanoparticles Cancer Therapy.
Carcinogenesis
CSNK2A1 Promotes Gastric Cancer Invasion Through the PI3K-Akt-mTOR Signaling Pathway.
Carcinogenesis
Current overview of the role of Akt in cancer studies via applied immunohistochemistry.
Carcinogenesis
Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2.
Carcinogenesis
CX-F9, a novel RSK2 inhibitor, suppresses cutaneous melanoma cells proliferation and metastasis through regulating autophagy.
Carcinogenesis
CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression.
Carcinogenesis
Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.
Carcinogenesis
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Carcinogenesis
Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
Carcinogenesis
Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.
Carcinogenesis
Deficiency of IKK? inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
Carcinogenesis
Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics.
Carcinogenesis
Detection of 14-3-3 sigma (?) promoter methylation as a noninvasive biomarker using blood samples for breast cancer diagnosis.
Carcinogenesis
Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression.
Carcinogenesis
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Carcinogenesis
DNA Damage-Induced Protein 14-3-3 {sigma} Inhibits Protein Kinase B/Akt Activation and Suppresses Akt-Activated Cancer.
Carcinogenesis
Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: Suppression of serine/threonine and tyrosine kinases.
Carcinogenesis
Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction.
Carcinogenesis
Down-regulation of TRAF4 targeting RSK4 inhibits proliferation, invasion and metastasis in breast cancer xenografts.
Carcinogenesis
Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.
Carcinogenesis
Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer.
Carcinogenesis
Drug design by machine-trained elastic networks: predicting Ser/Thr-protein kinase inhibitors' activities.
Carcinogenesis
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: the role of GSK-3beta in the maintenance of steady-state levels of insulin receptor signaling molecules and Na(v)1.7 sodium channel in adrenal chromaffin cells.
Carcinogenesis
Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase.
Carcinogenesis
Dysregulation of GSK3?-Target Proteins in Skin Fibroblasts of Myotonic Dystrophy Type 1 (DM1) Patients.
Carcinogenesis
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Carcinogenesis
Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.
Carcinogenesis
Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.
Carcinogenesis
Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response.
Carcinogenesis
Endometriosis-associated Extraovarian Malignancies: A Challenging Question for the Clinician and the Pathologist.
Carcinogenesis
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.
Carcinogenesis
Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.
Carcinogenesis
Estrogen receptor alpha transcriptionally activates casein kinase 2 alpha: A pivotal regulator of promyelocytic leukaemia protein (PML) and AKT in oncogenesis.
Carcinogenesis
Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways.
Carcinogenesis
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors.
Carcinogenesis
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.
Carcinogenesis
Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas.
Carcinogenesis
Exogenous activation of LKB1/AMPK signaling induces G? arrest in cells with endogenous LKB1 expression.
Carcinogenesis
Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma.
Carcinogenesis
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Carcinogenesis
Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
Carcinogenesis
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Carcinogenesis
Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.
Carcinogenesis
Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage.
Carcinogenesis
Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney.
Carcinogenesis
Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
Carcinogenesis
Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis.
Carcinogenesis
Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling.
Carcinogenesis
Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.
Carcinogenesis
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.
Carcinogenesis
Forskolin exerts anticancer roles in non-Hodgkin's lymphomas via regulating Axin/?-catenin signaling pathway.
Carcinogenesis
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Carcinogenesis
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity.
Carcinogenesis
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.
Carcinogenesis
Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age.
Carcinogenesis
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Carcinogenesis
Generating Conformation-Specific Polyclonal and Monoclonal Anti-Protein Kinase C Antibodies and Anti-Active State Specific PKC Antibodies.
Carcinogenesis
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Carcinogenesis
Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.
Carcinogenesis
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Carcinogenesis
GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways.
Carcinogenesis
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Carcinogenesis
Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site.
Carcinogenesis
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy.
Carcinogenesis
GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics.
Carcinogenesis
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
Carcinogenesis
GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression.
Carcinogenesis
Helicobacter pylori induces cell migration and invasion through casein kinase 2 in gastric epithelial cells.
Carcinogenesis
Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo(-/-) mice.
Carcinogenesis
Hepatitis B virus surface proteins accelerate cholestatic injury and tumor progression in Abcb4-knockout mice.
Carcinogenesis
Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis.
Carcinogenesis
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.
Carcinogenesis
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Carcinogenesis
Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
Carcinogenesis
Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis.
Carcinogenesis
Hypomethylation of the 14-3-3? promoter leads to increased expression in non-small cell lung cancer.
Carcinogenesis
IC261, a specific inhibitor of CK1?/?, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer.
Carcinogenesis
Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
Carcinogenesis
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Carcinogenesis
Identification and molecular characterization of the Pim1 serine/threonine kinase homolog in Litopenaeus vannamei.
Carcinogenesis
Identification and validation of key genes associated with non-small-cell lung cancer.
Carcinogenesis
Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach.
Carcinogenesis
Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.
Carcinogenesis
Identification of human hepatocellular carcinoma-related biomarkers by two-dimensional difference gel electrophoresis and mass spectrometry.
Carcinogenesis
Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif.
Carcinogenesis
Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion.
Carcinogenesis
Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
Carcinogenesis
Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
Carcinogenesis
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
Carcinogenesis
In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.
Carcinogenesis
In vitro phosphorylation of caveolin-rich membrane domains: identification of an associated serine kinase activity as a casein kinase II-like enzyme.
Carcinogenesis
In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
Carcinogenesis
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Carcinogenesis
Inactivation of RASSF1A, RARbeta2 and DAP-kinase by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma.
Carcinogenesis
Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors.
Carcinogenesis
Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats.
Carcinogenesis
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
Carcinogenesis
Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.
Carcinogenesis
Infliximab inhibits DNA repair in ultraviolet B-irradiated premalignant keratinocytes.
Carcinogenesis
Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.
Carcinogenesis
Inhibition of casein kinase II reduces TGF? induced fibroblast activation and ameliorates experimental fibrosis.
Carcinogenesis
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Carcinogenesis
Inhibition of the PI3K/AKT-NF-?B pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma.
Carcinogenesis
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Carcinogenesis
Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation.
Carcinogenesis
Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model.
Carcinogenesis
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Carcinogenesis
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition.
Carcinogenesis
Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues.
Carcinogenesis
Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.
Carcinogenesis
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Carcinogenesis
Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis.
Carcinogenesis
Knockdown of A-kinase anchor protein 4 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/?-catenin pathway in human gastric cancer cells.
Carcinogenesis
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Carcinogenesis
Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.
Carcinogenesis
Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model.
Carcinogenesis
Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38.
Carcinogenesis
LC-0882 targets PAK4 and inhibits PAK4-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.
Carcinogenesis
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
Carcinogenesis
LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy.
Carcinogenesis
LINC00339 regulates ROCK1 by miR-152 to promote cell proliferation and migration in hepatocellular carcinoma.
Carcinogenesis
LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
Carcinogenesis
Litopenaeus vannamei CK2 is involved in shrimp innate immunity by modulating hemocytes apoptosis.
Carcinogenesis
LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.
Carcinogenesis
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
Carcinogenesis
Long non-coding RNA SNHG5 sponges miR-26a to promote the tumorigenesis of osteosarcoma by targeting ROCK1.
Carcinogenesis
Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers.
Carcinogenesis
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Carcinogenesis
Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.
Carcinogenesis
LRRK2 is a candidate prognostic biomarker for clear cell renal cell carcinoma.
Carcinogenesis
Lysophosphatidic acid-RAGE axis promotes lung and mammary oncogenesis via protein kinase B and regulating tumor microenvironment.
Carcinogenesis
Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.
Carcinogenesis
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.
Carcinogenesis
Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase.
Carcinogenesis
Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature.
Carcinogenesis
Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.
Carcinogenesis
MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase.
Carcinogenesis
MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4.
Carcinogenesis
MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.
Carcinogenesis
MicroRNA-26b-5p enhances T cell responses by targeting PIM-2 in hepatocellular carcinoma.
Carcinogenesis
MicroRNA?16?5p regulates cell survival, cell cycle and apoptosis by targeting AKT3 in prostate cancer cells.
Carcinogenesis
MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1.
Carcinogenesis
Mixed lineage kinase-4 promotes gastric carcinoma tumorigenesis through suppression of the c-Jun N-terminal kinase signaling pathway.
Carcinogenesis
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Carcinogenesis
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Carcinogenesis
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Carcinogenesis
Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family.
Carcinogenesis
Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma.
Carcinogenesis
Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel.
Carcinogenesis
MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.
Carcinogenesis
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
Carcinogenesis
Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer.
Carcinogenesis
Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target.
Carcinogenesis
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.
Carcinogenesis
NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
Carcinogenesis
NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression.
Carcinogenesis
Notch signaling via regulation of RB and p-AKT but not PIK3CG contributes to MIA PaCa-2 cell growth and migration to affect pancreatic carcinogenesis.
Carcinogenesis
NUCKS nuclear elevated expression indicates progression and prognosis of ovarian cancer.
Carcinogenesis
NUCKS1 overexpression is a novel biomarker for recurrence-free survival in cervical squamous cell carcinoma.
Carcinogenesis
Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-?-inducible protein 10 in a casein kinase 2-dependent manner.
Carcinogenesis
Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-?B-activating potential.
Carcinogenesis
Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.
Carcinogenesis
Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.
Carcinogenesis
Overexpression and activation of Akt2 protein in oral squamous cell carcinoma.
Carcinogenesis
Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells.
Carcinogenesis
Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer.
Carcinogenesis
p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion.
Carcinogenesis
p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.
Carcinogenesis
Paired box gene 5 may modulate Proviral Integration of Moloney virus2gene and protein expression in mature B-cells.
Carcinogenesis
PAK1 tyrosine phosphorylation is required to induce epithelial-mesenchymal transition and radioresistance in lung cancer cells.
Carcinogenesis
Papillary thyroid carcinoma in a 9-year-old girl with ataxia-telangiectasia.
Carcinogenesis
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.
Carcinogenesis
PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.
Carcinogenesis
PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound.
Carcinogenesis
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors.
Carcinogenesis
Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC).
Carcinogenesis
Phytoconstituents and Medicinal Plants for Anticancer Drug Discovery: Computational Identification of Potent Inhibitors of PIM1 Kinase.
Carcinogenesis
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
Carcinogenesis
Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.
Carcinogenesis
Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.
Carcinogenesis
Pim-2 Activates API-5 to Inhibit the Apoptosis of Hepatocellular Carcinoma Cells Through NF-kappaB Pathway.
Carcinogenesis
Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.
Carcinogenesis
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
Carcinogenesis
PKA RI?/A-kinase anchoring proteins 10 signaling pathway and the prognosis of colorectal cancer.
Carcinogenesis
PKN1 modulates TGF? and EGF signaling in HEC-1-A endometrial cancer cell line.
Carcinogenesis
Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population.
Carcinogenesis
Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9, a zinc finger protein.
Carcinogenesis
Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.
Carcinogenesis
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Carcinogenesis
Prognostic implications of phosphatidylinositol 3-kinase/AKT signaling pathway activation in gastric carcinomas.
Carcinogenesis
Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.
Carcinogenesis
Prognostic value of activated Akt expression in oral squamous cell carcinoma.
Carcinogenesis
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinogenesis
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Carcinogenesis
Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
Carcinogenesis
Protein kinase CK2? catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Carcinogenesis
Protein kinase D1 attenuates tumorigenesis in colon cancer by modulating ?-catenin/T cell factor activity.
Carcinogenesis
Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway.
Carcinogenesis
Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.
Carcinogenesis
Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells.
Carcinogenesis
Quantitative Analysis of Ubiquitinated Proteins in Human Pituitary and Pituitary Adenoma Tissues.
Carcinogenesis
Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer.
Carcinogenesis
Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.
Carcinogenesis
Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane.
Carcinogenesis
Receptor for activated C kinase 1 (RACK1) promotes the progression of OSCC via the AKT/mTOR pathway.
Carcinogenesis
Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation.
Carcinogenesis
Regorafenib sensitizes human breast cancer cells to radiation by inhibiting multiple kinases and inducing DNA damage.
Carcinogenesis
Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
Carcinogenesis
Regulation of glycogen synthase kinase 3beta functions by modification of the small ubiquitin-like modifier.
Carcinogenesis
Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases.
Carcinogenesis
Regulation of tumorigenic splicing by protein condensates with specific biophysical properties.
Carcinogenesis
Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.
Carcinogenesis
Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes.
Carcinogenesis
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
Carcinogenesis
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Carcinogenesis
RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3.
Carcinogenesis
RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer.
Carcinogenesis
RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Carcinogenesis
RO3280, A Novel PLK1 Inhibitor, Suppressed Proliferation of MCF-7 Breast Cancer Cells Through Induction of Cell Cycle Arrest at G2/M Point.
Carcinogenesis
ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
Carcinogenesis
Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation.
Carcinogenesis
Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.
Carcinogenesis
Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine.
Carcinogenesis
Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance.
Carcinogenesis
Role of the oncogenic Raf-1 in orchestration of discrete nuclear factor-kappaB-activating pathways.
Carcinogenesis
Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.
Carcinogenesis
SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest.
Carcinogenesis
Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells.
Carcinogenesis
Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
Carcinogenesis
Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.
Carcinogenesis
ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer.
Carcinogenesis
Significance of nuclear p-Akt in endometrial carcinogenesis: rapid translocation of p-Akt Into the nucleus by estrogen, possibly resulting in inhibition of apoptosis.
Carcinogenesis
Silencing Aurora-A with siRNA inhibits cell proliferation in human lung adenocarcinoma cells.
Carcinogenesis
Silencing of casein kinase 2 inhibits PKC?induced cell invasion by targeting MMP?9 in MCF?7 cells.
Carcinogenesis
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Carcinogenesis
SMG-1 inhibition by miR-192/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling.
Carcinogenesis
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
Carcinogenesis
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.
Carcinogenesis
Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues.
Carcinogenesis
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Carcinogenesis
Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis.
Carcinogenesis
Stable knockdown of protein kinase CK2-alpha (CK2?) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells.
Carcinogenesis
STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
Carcinogenesis
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Carcinogenesis
STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.
Carcinogenesis
Structural insights into mis-regulation of protein kinase A in human tumors.
Carcinogenesis
Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR.
Carcinogenesis
Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene.
Carcinogenesis
Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains.
Carcinogenesis
STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling.
Carcinogenesis
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.
Carcinogenesis
Suppression of multiple processes relevant to cancer progression by benzyl isothiocyanate may result from the inhibition of Aurora A kinase activity.
Carcinogenesis
Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032.
Carcinogenesis
Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.
Carcinogenesis
Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials.
Carcinogenesis
Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.
Carcinogenesis
Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.
Carcinogenesis
Targeting molecules to medicine with mTOR, autophagy, and neurodegenerative disorders.
Carcinogenesis
Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells.
Carcinogenesis
TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases.
Carcinogenesis
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.
Carcinogenesis
The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines.
Carcinogenesis
The Apoptosis Regulator 14-3-3? and Its Potential as a Therapeutic Target in Pituitary Oncocytoma.
Carcinogenesis
The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network.
Carcinogenesis
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Carcinogenesis
The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C.
Carcinogenesis
The induction of endoreduplication and polyploidy by elevated expression of 14-3-3?.
Carcinogenesis
The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.
Carcinogenesis
The nuclear receptor peroxisome proliferator-activated receptor-?/? (PPAR?/?) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.
Carcinogenesis
The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.
Carcinogenesis
The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression.
Carcinogenesis
The PPLA motif of glycogen synthase kinase 3beta is required for interaction with Fe65.
Carcinogenesis
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors.
Carcinogenesis
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinogenesis
The role of the c-Jun N-terminal kinase 2-?-isoform in non-small cell lung carcinoma tumorigenesis.
Carcinogenesis
The scaffold protein IB1/JIP-1 controls the activation of JNK in rat stressed urothelium.
Carcinogenesis
The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-? precursor protein-dependent mechanism.
Carcinogenesis
The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.
Carcinogenesis
The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.
Carcinogenesis
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.
Carcinogenesis
Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes.
Carcinogenesis
Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.
Carcinogenesis
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.
Carcinogenesis
Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis.
Carcinogenesis
Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues.
Carcinogenesis
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy.
Carcinogenesis
Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions.
Carcinogenesis
TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma.
Carcinogenesis
Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching.
Carcinogenesis
UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
Carcinogenesis
Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma.
Carcinogenesis
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.
Carcinogenesis
Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B.
Carcinogenesis
Various AKIP1 expression levels affect its subcellular localization but have no effect on NF-kappaB activation.
Carcinogenesis
Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinogenesis
Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.
Carcinogenesis
Wnt/?-catenin activation and macrophage induction during liver cancer development following steatosis.
Carcinogenesis
[Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]
Carcinogenesis
[Change in the protein kinase activity of glandular stomach mucosa in rats during malignant transformation]
Carcinogenesis
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Carcinogenesis
[Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer]
Carcinogenesis
[Effect of Bmi-1 Silencing on the Proliferation of K562/ADM Cells in vitro and in vivo].
Carcinogenesis
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Carcinogenesis
[Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma].
Carcinogenesis
[Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis]
Carcinogenesis
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Carcinogenesis
[The over-expression of serine/threonine kinase 15 protein in oral carcinogenesis]
Carcinogenesis
[The underlying mechanisms of overcoming EGFR-TKIs resistance by casein kinase 2 inhibitor].
Carcinoid Tumor
Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation.
Carcinoid Tumor
Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors.
Carcinoid Tumor
Expression of p-AKT and p-mTOR in a large series of bronchopulmonary neuroendocrine tumors.
Carcinoid Tumor
Focal Adhesion Kinase, a Downstream Mediator of Raf-1 Signaling, Suppresses Cellular Adhesion, Migration, and Neuroendocrine Markers in BON Carcinoid Cells.
Carcinoid Tumor
Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours.
Carcinoid Tumor
Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth.
Carcinoid Tumor
Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion.
Carcinoid Tumor
Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells.
Carcinoid Tumor
Synergistic Effect of Pasireotide and Teriflunomide in Carcinoids in vitro.
Carcinoid Tumor
Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.
Carcinoid Tumor
ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells.
Carcinoma
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Carcinoma
14-3-3 protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid.
Carcinoma
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Carcinoma
14-3-3? silencing retards tongue squamous cell carcinoma progression by inhibiting cell survival and migration.
Carcinoma
7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ER?, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway.
Carcinoma
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Carcinoma
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Carcinoma
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
Carcinoma
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Carcinoma
A novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression.
Carcinoma
A-kinase interacting protein 1 high expression correlates with advanced tumor stage and poor overall survival in surgical patients with clear cell renal cell carcinoma.
Carcinoma
Aberrant methylation of the death-associated protein kinase 1 (DAPK1) CpG island in chronic myeloid leukemia.
Carcinoma
Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma.
Carcinoma
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Carcinoma
Activation of AKT in feline mammary carcinoma: A new prognostic factor for feline mammary tumours.
Carcinoma
Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin.
Carcinoma
Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.
Carcinoma
Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine.
Carcinoma
Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells.
Carcinoma
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Carcinoma
Activation of the protein kinase a signal transduction pathway by granulocyte-macrophage colony-stimulating factor or by genetic manipulation reduces cytoskeletal organization in Lewis lung carcinoma variants.
Carcinoma
Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia.
Carcinoma
Adenylate cyclase and protein phosphokinase activities in human thyroid. Comparison of normal glands, hyperfunctional nodules and carcinomas.
Carcinoma
Akt activation correlates with the tumor aggressiveness in Tunisian patients with bladder cancer.
Carcinoma
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Carcinoma
Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei.
Carcinoma
Aloe-emodin, an anthraquinone, in vitro inhibits proliferation and induces apoptosis in human colon carcinoma cells.
Carcinoma
Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer.
Carcinoma
Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.
Carcinoma
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas.
Carcinoma
An automated image capture and quantitation approach to identify proteins affecting tumor cell proliferation.
Carcinoma
Analysis of Cell-type Specific Expression of CK1{varepsilon} in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag Transgenic Mice.
Carcinoma
Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma.
Carcinoma
Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29.
Carcinoma
Antisense oligonucleotides against protein kinase CK2-alpha inhibit growth of squamous cell carcinoma of the head and neck in vitro.
Carcinoma
Antitumor effect and potentiation or reduction in cytotoxic drug activity in human colon carcinoma cells by the Raf kinase inhibitor (RKI) BAY 43-9006.
Carcinoma
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
Carcinoma
Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study.
Carcinoma
Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2.
Carcinoma
Association of elevated protein kinase CK2 activity with aggressive behavior of squamous cell carcinoma of the head and neck.
Carcinoma
Associations of ATM Polymorphisms With Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Receiving Radiation Therapy.
Carcinoma
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Carcinoma
ATGL promotes the proliferation of hepatocellular carcinoma cells via the p-AKT signaling pathway.
Carcinoma
Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers.
Carcinoma
Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.
Carcinoma
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.
Carcinoma
Aurora B expression in metastatic effusions from advanced-stage ovarian serous carcinoma is predictive of intrinsic chemotherapy resistance.
Carcinoma
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma
B-raf exon 15 mutations are common in primary melanoma resection specimens but not associated with clinical outcome.
Carcinoma
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Carcinoma
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Carcinoma
BDNF/TrkB/Akt Signaling Pathway Epithelial Odontogenic Tumors and Keratocyst: An Immunohistochemical Study Comparative With Dental Germs.
Carcinoma
Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.
Carcinoma
Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis.
Carcinoma
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
Carcinoma
c-erbB-2 oncoprotein expression related to chemoradioresistance in esophageal squamous cell carcinoma.
Carcinoma
c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines.
Carcinoma
Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma.
Carcinoma
Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation.
Carcinoma
Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines.
Carcinoma
Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.
Carcinoma
Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung.
Carcinoma
Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).
Carcinoma
Caveolin-1 and 14-3-3 sigma expression in follicular variant of thyroid papillary carcinoma.
Carcinoma
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.
Carcinoma
Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.
Carcinoma
Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean (Phaseolus vulgaris L.).
Carcinoma
Characterization of casein kinase II in human colonic carcinomas after heterotransplantation into nude mice.
Carcinoma
Checkpoint kinase 1 inhibitors as targeted molecular agents for clear cell carcinoma of the ovary.
Carcinoma
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Carcinoma
Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c?Raf/MEK/ERK signaling pathway.
Carcinoma
Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma.
Carcinoma
Clinical and biological significance of GSK-3beta inactivation in breast cancer-an immunohistochemical study.
Carcinoma
Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.
Carcinoma
Clinical significance of raf-1 kinase inhibitor protein in oral squamous cell carcinoma and its role in cell metastasis.
Carcinoma
Clinicopathological and biological analysis of PIK3CA mutation and amplification in cervical carcinomas.
Carcinoma
Clinicopathological features and prognostic implications of Raf kinase inhibitor protein downregulation in tongue squamous cell carcinoma.
Carcinoma
Clinicopathological significance of ribosomal protein S6 kinase A6 in lung squamous cell carcinoma: an immunohistochemical and RNA-seq study.
Carcinoma
Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells.
Carcinoma
Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma.
Carcinoma
Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma.
Carcinoma
Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues.
Carcinoma
Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.
Carcinoma
Constitutive activation of glycogen synthase kinase-3beta correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer.
Carcinoma
Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression.
Carcinoma
Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression.
Carcinoma
CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy.
Carcinoma
Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells.
Carcinoma
Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer.
Carcinoma
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Carcinoma
Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin- and CaM kinase-like-1-positive tuft cells.
Carcinoma
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Carcinoma
DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer.
Carcinoma
Decreased expression and aberrant methylation of Raf kinase inhibitory protein gene in esophageal squamous cell carcinoma.
Carcinoma
Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
Carcinoma
Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas.
Carcinoma
Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma.
Carcinoma
Different cellular localization, translocation, and insulin-induced phosphorylation of PKBalpha in HepG2 cells and hepatocytes.
Carcinoma
Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma.
Carcinoma
Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
Carcinoma
Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract.
Carcinoma
Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma - no evidence for an overexpression of protein kinase B.
Carcinoma
Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma.
Carcinoma
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Carcinoma
Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features.
Carcinoma
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
Carcinoma
DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer.
Carcinoma
DNA-dependent protein kinase catalytic subunit functions in metastasis and influences survival in advanced-stage laryngeal squamous cell carcinoma.
Carcinoma
DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines.
Carcinoma
DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues.
Carcinoma
DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.
Carcinoma
DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery.
Carcinoma
DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-?1/Smad Signaling Pathway.
Carcinoma
Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast.
Carcinoma
Downregulation of 14-3-3? inhibits proliferation and migration in osteosarcoma cells.
Carcinoma
Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway.
Carcinoma
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival.
Carcinoma
Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth.
Carcinoma
Editorial comment on: Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma
Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.
Carcinoma
Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas.
Carcinoma
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Carcinoma
Effects of siRNA specific to the protein kinase CK2? on apoptosis of laryngeal carcinoma cells.
Carcinoma
EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: Role of c-Jun N-terminal kinase.
Carcinoma
EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma.
Carcinoma
Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Carcinoma
Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells.
Carcinoma
Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: association with p16(INK4a) silencing and human papillomavirus negativity.
Carcinoma
ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway.
Carcinoma
Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma.
Carcinoma
Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats.
Carcinoma
Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma.
Carcinoma
Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression.
Carcinoma
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Carcinoma
Expression and prognostic significance of pyruvate dehydrogenase kinase 1 in bladder urothelial carcinoma.
Carcinoma
Expression and prognostic significance of the P53-related DNA damage repair proteins checkpoint kinase 1 (CHK1) and growth arrest and DNA-damage-inducible 45 alpha (GADD45A) in human oral squamous cell carcinoma.
Carcinoma
Expression and Significance of RKIP and E-cadherin in Lung Squamous Cell Carcinoma.
Carcinoma
Expression of 14-3-3 sigma and eta proteins is unrelated to survival in metastatic high-grade serous carcinoma.
Carcinoma
Expression of Abl interactor 1 and its prognostic significance in breast cancer: a tissue-array-based investigation.
Carcinoma
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Carcinoma
Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma.
Carcinoma
Expression of Concern: Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma
Expression of cyclin D1 and GSK-3beta and their predictive value of prognosis in squamous cell carcinomas of the tongue.
Carcinoma
Expression of DNA-dependent protein kinase catalytic subunit in laryngeal squamous cell carcinoma and its importance.
Carcinoma
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Carcinoma
Expression of HSP70 and JNK-related proteins in human liver cancer: Potential effects on clinical outcome.
Carcinoma
Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma.
Carcinoma
Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses.
Carcinoma
Expression of p-Akt in ovarian serous carcinoma and its association with proliferation and apoptosis.
Carcinoma
Expression of P-Akt, NFkappaB and their correlation with human papillomavirus infection in cervical carcinoma.
Carcinoma
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis.
Carcinoma
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Carcinoma
Expression of phosphorylated Akt in patients with small cell carcinoma of the lung indicates good prognosis.
Carcinoma
Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.
Carcinoma
Expression of protein tyrosine kinases in head and neck squamous cell carcinomas.
Carcinoma
Expression of Raf-1 kinase inhibitory protein in carcinoma of the ampulla of Vater.
Carcinoma
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
Carcinoma
Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
Carcinoma
Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance.
Carcinoma
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Carcinoma
Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings.
Carcinoma
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.
Carcinoma
Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.
Carcinoma
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Carcinoma
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Carcinoma
Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation.
Carcinoma
Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition.
Carcinoma
G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling.
Carcinoma
Gene sequencing and expression of Raf-1 in lymphatic metastasis of hypopharyngeal carcinoma.
Carcinoma
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
Carcinoma
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Carcinoma
Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.
Carcinoma
Glycogen synthase kinase-3 beta (GSK3?)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma.
Carcinoma
Granulocyte-macrophage colony-stimulating factor stimulates the metastatic properties of Lewis lung carcinoma cells through a protein kinase A signal-transduction pathway.
Carcinoma
GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Carcinoma
GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC).
Carcinoma
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
Carcinoma
HER-2/AKT expression in upper urinary tract urothelial carcinoma: prognostic implications.
Carcinoma
High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.
Carcinoma
HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.
Carcinoma
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.
Carcinoma
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Carcinoma
Histamine inhibits the production of interferon-induced protein of 10 kDa in human squamous cell carcinoma and melanoma.
Carcinoma
Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.
Carcinoma
Hypermethylation-mediated partial transcriptional silencing of DAP-kinase gene in bladder cancer.
Carcinoma
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis.
Carcinoma
Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness.
Carcinoma
Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes.
Carcinoma
ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway.
Carcinoma
Immunohistochemical and genetic characteristics of HPV-associated endocervical carcinoma with an invasive stratified mucin-producing carcinoma (ISMC) component.
Carcinoma
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
Carcinoma
Immunohistochemical expression of PDGFR, VEGF-C, and proteins of the mToR pathway before and after androgen deprivation therapy in prostate carcinoma: significant decrease after treatment.
Carcinoma
Immunologically defined subclasses of the protein kinase CK2 beta-subunit in prostate carcinoma cell lines.
Carcinoma
In Silico-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma.
Carcinoma
Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression.
Carcinoma
Incremental Expression of 14-3-3 Protein Beta/Alpha in Urine Correlates with Advanced Stage and Poor Survival in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells.
Carcinoma
Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway.
Carcinoma
Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry".
Carcinoma
Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells.
Carcinoma
Inhibition of Ataxia-Telangiectasia Mutated by Antisense Oligonucleotide Nanoparticles Induces Radiosensitization of Head and Neck Squamous-Cell Carcinoma in Mice.
Carcinoma
Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells.
Carcinoma
Inhibition of glycogen synthase kinase 3 beta (GSK3?) suppresses the progression of esophageal squamous cell carcinoma by modifying STAT3 activity.
Carcinoma
Inhibition of glycolysis enhances cisplatin-induced apoptosis in ovarian cancer cells.
Carcinoma
Inhibition of p21-activated kinase 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway.
Carcinoma
Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells.
Carcinoma
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Carcinoma
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.
Carcinoma
Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability.
Carcinoma
Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.
Carcinoma
Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite.
Carcinoma
Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells.
Carcinoma
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Carcinoma
Involvement of the Wnt-?-catenin pathway in invasion and migration of oral squamous carcinoma cells.
Carcinoma
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells.
Carcinoma
Irciniastatin A induces potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung carcinoma A549 cells.
Carcinoma
Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/?-catenin signalling and epithelial-mesenchymal transition (EMT).
Carcinoma
Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration.
Carcinoma
KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
Carcinoma
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Carcinoma
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Carcinoma
Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells.
Carcinoma
Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma.
Carcinoma
LncRNA EGFR-AS1 Upregulates ROCK1 by Sponging miR-145 to Promote Esophageal Squamous Cell Carcinoma Cell Invasion and Migration.
Carcinoma
lncRNA HAND2-AS1 inhibits cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and negative cervical squamous cell carcinoma.
Carcinoma
Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma
Long noncoding RNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1.
Carcinoma
Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1.
Carcinoma
Loss of 14-3-3 sigma protein expression and presence of human papillomavirus type 16 E6 in oral squamous cell carcinoma.
Carcinoma
Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma.
Carcinoma
LY294002 enhances inhibitory effect of gemcitabine on proliferation of human pancreatic carcinoma PANC-1 cells.
Carcinoma
MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
Carcinoma
MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.
Carcinoma
Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats.
Carcinoma
Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study.
Carcinoma
Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway.
Carcinoma
Methylation of STK11 promoter is a risk factor for tumor stage and survival in clear cell renal cell carcinoma.
Carcinoma
MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.
Carcinoma
MicroRNA-140-5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21-activated kinase 4.
Carcinoma
MicroRNA-148b inhibits proliferation and the epithelial-mesenchymal transition and increases radiosensitivity in non-small cell lung carcinomas by regulating ROCK1.
Carcinoma
MicroRNA?122 downregulates Rho?associated protein kinase 2 expression and inhibits the proliferation of prostate carcinoma cells.
Carcinoma
MicroRNA?195 inhibits cell proliferation, migration and invasion in laryngeal squamous cell carcinoma by targeting ROCK1.
Carcinoma
Mixed lineage kinase-4 promotes gastric carcinoma tumorigenesis through suppression of the c-Jun N-terminal kinase signaling pathway.
Carcinoma
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.
Carcinoma
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
Carcinoma
Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
Carcinoma
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Carcinoma
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1.
Carcinoma
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Carcinoma
Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.
Carcinoma
Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells.
Carcinoma
Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma.
Carcinoma
Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation.
Carcinoma
Overexpression of glycogen synthase kinase-3 in ovarian carcinoma cells with acquired Paclitaxel resistance.
Carcinoma
Overexpression of Nuclear Protein Kinase CK2 beta Subunit and Prognosis in Human Gastric Carcinoma.
Carcinoma
Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.
Carcinoma
Overexpression of platelet-derived growth factor-B increases the growth, invasion, and angiogenesis of gastric carcinoma cells through protein kinase B.
Carcinoma
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Carcinoma
Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.
Carcinoma
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.
Carcinoma
Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients.
Carcinoma
Overexpression of the mitotic spindle assembly checkpoint genes hBUB1, hBUBR1 and hMAD2 in thyroid carcinomas with aggressive nature.
Carcinoma
p-Akt and its relationship with clinicopathological features and survival in oral squamous cell carcinoma: an immunohistochemical study.
Carcinoma
p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma.
Carcinoma
p21-activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1.
Carcinoma
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Carcinoma
PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.
Carcinoma
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
Carcinoma
Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3 beta mediated regulation of p21 in human urothelial carcinoma cells.
Carcinoma
Phospho-?Np63?-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
Carcinoma
Phosphorylated p63 induces transcription of regulatory particle non ATP-ase subunit 13 and nitric oxide synthase-2 protein degradation.
Carcinoma
Phosphorylation of glycogen synthase kinase-3 beta at serine 9 confers cisplatin resistance in ovarian cancer cells.
Carcinoma
Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.
Carcinoma
PI3K/AKT pathway genetic alterations and dysregulation of expression in bladder cancer.
Carcinoma
PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma.
Carcinoma
Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity.
Carcinoma
Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathway.
Carcinoma
PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells.
Carcinoma
Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases.
Carcinoma
Preponderance of the oncogenic V599E and V599K mutations in the B-raf kinase domain is enhanced in melanoma lymph node metastases.
Carcinoma
Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas.
Carcinoma
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma
Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression.
Carcinoma
Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: A meta-analysis.
Carcinoma
Prognostic Value of Raf Kinase Inhibitor Protein in Esophageal Squamous Cell Carcinoma.
Carcinoma
Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.
Carcinoma
Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.
Carcinoma
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma
Promoter methylation and expression of Raf kinase inhibitory protein in esophageal squamous cell carcinoma.
Carcinoma
Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas.
Carcinoma
Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.
Carcinoma
Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis.
Carcinoma
Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells.
Carcinoma
Protein kinase B promotes radiation-induced regulatory T cell survival in bladder carcinoma.
Carcinoma
Protein kinase C and casein kinase II activities in two human colon carcinoma cell lines, HT-29 and CaCo-2: possible correlation with differentiation.
Carcinoma
Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells.
Carcinoma
Protein kinase D distribution in normal human epidermis, basal cell carcinoma and psoriasis.
Carcinoma
Protein kinase D1 induced epithelial-mesenchymal transition and invasion in salivary adenoid cystic carcinoma via E-cadherin/Snail regulation.
Carcinoma
Protein phosphatases-1 and -2A regulate tumor cell migration, invasion and cytoskeletal organization.
Carcinoma
Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells.
Carcinoma
Proteomic profiling of differential display analysis for human oral squamous cell carcinoma: 14-3-3 ? Protein is upregulated in human oral squamous cell carcinoma and dependent on the differentiation level.
Carcinoma
PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.
Carcinoma
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Carcinoma
Pyrvinium Sensitizes Clear Cell Renal Cell Carcinoma Response to Chemotherapy Via Casein Kinase 1?-Dependent Inhibition of Wnt/?-Catenin.
Carcinoma
Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells.
Carcinoma
Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma.
Carcinoma
Raf-1 kinase, epidermal growth factor receptors, and mutant Ras proteins in colonic carcinomas.
Carcinoma
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma
Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane.
Carcinoma
Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
Carcinoma
Reduced expression of Raf-1 kinase inhibitory protein in renal cell carcinoma: a significant prognostic marker.
Carcinoma
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Carcinoma
Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma.
Carcinoma
Reduced LRP6 expression and increase in the interaction of GSK3? with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea.
Carcinoma
Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells.
Carcinoma
Regulation of protein kinase A activation and prostaglandin E2-stimulated migration of Lewis lung carcinoma clones.
Carcinoma
Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a?p-AKT-dependent manner.
Carcinoma
Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cells.
Carcinoma
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma.
Carcinoma
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV.
Carcinoma
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
Carcinoma
RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
Carcinoma
Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
Carcinoma
RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.
Carcinoma
RNA interference (RNAi) mediated stable knockdown of protein casein kinase 2-alpha (CK2?) inhibits migration and invasion and enhances cisplatin-induced apoptosis in HEp-2 laryngeal carcinoma cells.
Carcinoma
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma
RUNX3 reverses cisplatin resistance in esophageal squamous cell carcinoma via suppression of the protein kinase B pathway.
Carcinoma
Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Carcinoma
Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.
Carcinoma
Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/?-catenin pathway.
Carcinoma
Silencing of the integrin-linked kinase gene induces the apoptosis in ovarian carcinoma.
Carcinoma
SMAD3 inducing the transcription of ?STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.
Carcinoma
SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.
Carcinoma
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Carcinoma
Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
Carcinoma
Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer.
Carcinoma
Stabilization of mismatch repair gene PMS2 by glycogen synthase kinase 3beta is implicated in the treatment of cervical carcinoma.
Carcinoma
Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.
Carcinoma
STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon.
Carcinoma
STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
Carcinoma
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Carcinoma
STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.
Carcinoma
STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-?1.
Carcinoma
Subcellular immunolocalization of protein kinase CK2 in normal and carcinoma cells.
Carcinoma
Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
Carcinoma
Synthesis and biological evaluation of nitroxide labeled pyrimidines as Aurora kinase inhibitors.
Carcinoma
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Carcinoma
Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-kappaB-dependent process in human cervical carcinoma cells.
Carcinoma
Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma.
Carcinoma
T7 Peptide-Conjugated Lipid Nanoparticles for Dual Modulation of Bcl-2 and Akt-1 in Lung and Cervical Carcinomas.
Carcinoma
Targeting 14-3-3?-CDC25A interactions to trigger apoptotic cell death in skin cancer.
Carcinoma
The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.
Carcinoma
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
Carcinoma
The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro.
Carcinoma
The enterocyte-like differentiation of the Caco-2 tumor cell line strongly correlates with responsiveness to cAMP and activation of kinase A pathway.
Carcinoma
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Carcinoma
The HNF-1?-USP28-Claspin pathway upregulates DNA damage-induced Chk1 activation in ovarian clear cell carcinoma.
Carcinoma
The in vitro effects of H-89, a specific inhibitor of protein kinase A, in the human colonic carcinoma cell line Caco-2.
Carcinoma
The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.
Carcinoma
The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo.
Carcinoma
The Mammalian Target of Rapamycin-70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma.
Carcinoma
The novel cancer-testis antigen A-kinase anchor protein 4 (AKAP4) is a potential target for immunotherapy of ovarian serous carcinoma.
Carcinoma
The oncogenic B-raf V599E mutation occurs more frequently in melanomas at sun-protected body sites.
Carcinoma
The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation.
Carcinoma
The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.
Carcinoma
The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation.
Carcinoma
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors.
Carcinoma
The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma
The putative tumour suppressor microRNA-145, repressed by c-jun, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma
The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
Carcinoma
The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells.
Carcinoma
The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells.
Carcinoma
The role of Aurora A in hypoxia-inducible factor 1?-promoting malignant phenotypes of hepatocelluar carcinoma.
Carcinoma
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinoma
The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism.
Carcinoma
The role of the c-Jun N-terminal kinase 2-?-isoform in non-small cell lung carcinoma tumorigenesis.
Carcinoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Carcinoma
The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.
Carcinoma
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XIV. Mutational and non-mutational mechanisms as subsets of a more general mechanism. Part C. A defined cancer mutation.
Carcinoma
Therapeutic targeting of protein kinase CK2 gene expression in feline oral squamous cell carcinoma - a naturally occurring large animal model of head and neck cancer.
Carcinoma
Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.
Carcinoma
TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.
Carcinoma
Toxoplasma gondii: effect of infection on expression of 14-3-3 proteins in human epithelial cells.
Carcinoma
Tumor DNA-dependent protein kinase catalytic subunit expression is associated with hepatitis B surface antigen status and tumor progression in patients with hepatocellular carcinoma.
Carcinoma
Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.
Carcinoma
Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.
Carcinoma
Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway.
Carcinoma
TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma.
Carcinoma
Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes.
Carcinoma
Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma.
Carcinoma
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Carcinoma
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.
Carcinoma
Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.
Carcinoma
Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.
Carcinoma
Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer.
Carcinoma
Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A.
Carcinoma
Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma
VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma.
Carcinoma
Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells.
Carcinoma
YWHAZ amplification/overexpression defines aggressive bladder cancer and contributes to chemo-/radio-resistance by suppressing caspase-mediated apoptosis.
Carcinoma
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Carcinoma
[Correlation between gene polymorphisms of Wnt signalling pathway related components and risk of gastric carcinoma: a case-control study]
Carcinoma
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Carcinoma
[Correlations between the p-Akt-mTOR-p70S6K pathway and clinicopathological features or chemoresistance of ovarian cancer].
Carcinoma
[Diagnostic value of protein markers in plasma exosomes of lung squamous cell carcinoma].
Carcinoma
[Effect of casein kinase 2? in esophageal carcinoma and its clinical significance].
Carcinoma
[Expression and clinical significance of epidermal growth factor receptor and protein kinase B in gastric carcinoma.]
Carcinoma
[Expression and clinical significance of phosphatidylinositol 3-kinase and protein kinase B in cervical carcinoma]
Carcinoma
[Expression and clinical significance of serine-threonine kinase/mammalian target of rapamycin/p70 S6K signal path- way in oral squamous cell carcinoma].
Carcinoma
[Expression and significance of p-AKT, p-GSK3? and ?-catenin in epithelial carcinoma of ovary].
Carcinoma
[Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].
Carcinoma
[Expression of PKB protein in human squamous-cell carcinoma and adenocarcinoma of lung]
Carcinoma
[Expressions of SMG-1, ATM and P53 in laryngeal squamous cell carcinoma and their clinical significance].
Carcinoma
[Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells]
Carcinoma
[Multiple forms of protein kinase from the cytoplasm of Ehrlich ascites carcinoma cells]
Carcinoma
[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]
Carcinoma
[Protein kinase D1 regulates the growth and metabolism of oral squamous carcinoma cells in tumor microenvironment].
Carcinoma
[Relationship between raf kinase inhibitor protein and metastasis of ovarian carcinoma]
Carcinoma
[Relationship between ROCK2 expression and clinicopathologic characteristics of esophageal squamous cell carcinoma].
Carcinoma
[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms]
Carcinoma
[The expression and activity of protein kinase A I in oral squamous cell carcinoma.]
Carcinoma
[The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma]
Carcinoma
[The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]
Carcinoma
[The study of serine/threonine kinase signaling pathway-mediated inhibition of proliferation and invasion of oral squamous cell carcinoma transfected with p53 gene].
Carcinoma in Situ
Immunohistochemical evaluation of ROCK activation in invasive breast cancer.
Carcinoma in Situ
Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration.
Carcinoma in Situ
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Carcinoma in Situ
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.
Carcinoma, Adenoid Cystic
Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.
Carcinoma, Adenoid Cystic
Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses.
Carcinoma, Adenoid Cystic
Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.
Carcinoma, Adenoid Cystic
Protein kinase D1 induced epithelial-mesenchymal transition and invasion in salivary adenoid cystic carcinoma via E-cadherin/Snail regulation.
Carcinoma, Adenoid Cystic
Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma.
Carcinoma, Adenoid Cystic
[Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells]
Carcinoma, Adenosquamous
Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.
Carcinoma, Basal Cell
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Carcinoma, Basal Cell
Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
Carcinoma, Basal Cell
Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.
Carcinoma, Basal Cell
Protein kinase D distribution in normal human epidermis, basal cell carcinoma and psoriasis.
Carcinoma, Basal Cell
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinoma, Basal Cell
Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.
Carcinoma, Basal Cell
Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes.
Carcinoma, Ductal
Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer.
Carcinoma, Ductal
Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.
Carcinoma, Ductal
Double Heterozygosity of BRCA2 and STK11 in Familial Breast Cancer Detected by Exome Sequencing.
Carcinoma, Ductal
Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells.
Carcinoma, Ductal
Elevated Expression of IRS-1 Associates with p-Akt Expression and Predicts Poor Prognosis of Breast Invasive Ductal Carcinoma.
Carcinoma, Ductal
Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast.
Carcinoma, Ductal
Immunoexpression of HER family, neuregulin, MAPK and AKT in invasive ductal carcinomas of the breast.
Carcinoma, Ductal
Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
Carcinoma, Ductal
Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
Carcinoma, Ductal
Protein kinase D1 inhibits breast cancer cell invasion via regulating matrix metalloproteinase expression.
Carcinoma, Ductal
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
Carcinoma, Ductal
Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach.
Carcinoma, Ductal
The differential expression of aqueous soluble proteins in breast normal and cancerous tissues in relation to ethnicity of the patients; Chinese, Malay and Indian.
Carcinoma, Ductal, Breast
Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma.
Carcinoma, Ehrlich Tumor
Characterization of highly phosphorylated subcomponents of rat thymus H1 histone.
Carcinoma, Ehrlich Tumor
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Carcinoma, Ehrlich Tumor
Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing.
Carcinoma, Ehrlich Tumor
Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Purification and characterization of a 400-kDa nonhistone chromatin protein that serves as an effective phosphate acceptor for casein kinase II from Ehrlich ascites tumor cells.
Carcinoma, Embryonal
14-3-3 protein family members have a regulatory role in retinoic acid-mediated induction of cytokeratins in F9 cells.
Carcinoma, Embryonal
Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter.
Carcinoma, Embryonal
G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation.
Carcinoma, Embryonal
Human testis phosphoproteome reveals kinases as potential targets in spermatogenesis and testicular cancer.
Carcinoma, Embryonal
Immunohistochemical expression of 14-3-3 sigma protein in human urological and gynecological tumors using a multi-tumor microarray analysis.
Carcinoma, Embryonal
MEKK4 mediates differentiation in response to retinoic acid via activation of c-Jun N-terminal kinase in rat embryonal carcinoma P19 cells.
Carcinoma, Embryonal
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells.
Carcinoma, Endometrioid
beta-catenin expression pattern in stage I and II ovarian carcinomas : relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome.
Carcinoma, Endometrioid
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Carcinoma, Endometrioid
[Correlations between the p-Akt-mTOR-p70S6K pathway and clinicopathological features or chemoresistance of ovarian cancer].
Carcinoma, Hepatocellular
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
Carcinoma, Hepatocellular
7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-?B, MMP2, and MMP9 Expression.
Carcinoma, Hepatocellular
8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.
Carcinoma, Hepatocellular
A ?Raf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures.
Carcinoma, Hepatocellular
A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity.
Carcinoma, Hepatocellular
A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish.
Carcinoma, Hepatocellular
A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.
Carcinoma, Hepatocellular
A novel casein kinase 2 alpha-subunit regulates membrane protein traffic in the human hepatoma cell line HuH-7.
Carcinoma, Hepatocellular
A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility.
Carcinoma, Hepatocellular
A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-Derived Neurotrophic Factor Inhibition and Glycogen Synthase Kinase 3 beta reactivation.
Carcinoma, Hepatocellular
A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.
Carcinoma, Hepatocellular
A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma.
Carcinoma, Hepatocellular
A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.
Carcinoma, Hepatocellular
A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase.
Carcinoma, Hepatocellular
A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.
Carcinoma, Hepatocellular
A single-center experience of sorafenib monotherapy in patients with advanced intrahepatic cholangiocarcinoma.
Carcinoma, Hepatocellular
A-kinase anchoring protein 12 is downregulated in human hepatocellular carcinoma and its deficiency in mice aggravates thioacetamide-induced liver injury.
Carcinoma, Hepatocellular
A-kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.
Carcinoma, Hepatocellular
Absolute Structures of Wedelolide Derivatives and Structure-Activity Relationships of Protein Tyrosine Phosphatase 1B Inhibitory ent-Kaurene Diterpenes from Aerial Parts of Wedelia spp. Collected in Indonesia and Japan.
Carcinoma, Hepatocellular
Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.
Carcinoma, Hepatocellular
Activation of AMP-activated Protein Kinase and Phosphorylation of Glycogen Synthase Kinase3 ? Mediate Ursolic Acid Induced Apoptosis in HepG2 Liver Cancer Cells.
Carcinoma, Hepatocellular
Activation of c-Jun N-terminal kinase in non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Activation of casein kinase II in response to insulin and to epidermal growth factor.
Carcinoma, Hepatocellular
Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene.
Carcinoma, Hepatocellular
Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin.
Carcinoma, Hepatocellular
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Carcinoma, Hepatocellular
Adiponectin induces apoptosis in hepatocellular carcinoma through differential modulation of thioredoxin proteins.
Carcinoma, Hepatocellular
Adiponectin modulates C-jun N-terminal kinase and Mammalian target of rapamycin and inhibits hepatocellular carcinoma.
Carcinoma, Hepatocellular
AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma.
Carcinoma, Hepatocellular
AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade.
Carcinoma, Hepatocellular
Alterations of beta-catenin and Tcf-4 instead of GSK-3beta contribute to activation of Wnt pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.
Carcinoma, Hepatocellular
Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Anti-malarial atovaquone exhibits anti-tumor effects by inducing DNA damage in hepatocellular carcinoma.
Carcinoma, Hepatocellular
ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
Carcinoma, Hepatocellular
Ataxia telangiectasia mutated inhibitor-loaded copper sulfide nanoparticles for low-temperature photothermal therapy of hepatocellular carcinoma.
Carcinoma, Hepatocellular
ATGL promotes the proliferation of hepatocellular carcinoma cells via the p-AKT signaling pathway.
Carcinoma, Hepatocellular
Aurora-A Overexpression in Mouse Liver Causes p53-Dependent Premitotic Arrest during Liver Regeneration.
Carcinoma, Hepatocellular
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer.
Carcinoma, Hepatocellular
Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability.
Carcinoma, Hepatocellular
AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Basic fibroblast growth factor upregulates survivin expression in hepatocellular carcinoma cells via a protein kinase B-dependent pathway.
Carcinoma, Hepatocellular
Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling.
Carcinoma, Hepatocellular
c-Jun N-terminal kinase inhibitor favors transforming growth factor?? to antagonize hepatitis B virus X protein?induced cell growth promotion in hepatocellular carcinoma.
Carcinoma, Hepatocellular
C/EBP? is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
Carcinoma, Hepatocellular
CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1? in Hepatoma Cells.
Carcinoma, Hepatocellular
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Carcinoma, Hepatocellular
Checkpoint kinase 1 is negatively regulated by miR-497 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Clinacanthus nutans (Burm. f.) Lindau Ethanol Extract Inhibits Hepatoma in Mice through Upregulation of the Immune Response.
Carcinoma, Hepatocellular
Clinical significance of serum 14-3-3 beta in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.
Carcinoma, Hepatocellular
Cloning of sgk serine-threonine protein kinase from shark rectal gland - a gene induced by hypertonicity and secretagogues
Carcinoma, Hepatocellular
Co-Upregulation of 14-3-3? and P-Akt is Associated with Oncogenesis and Recurrence of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Combretastatin A-4 disodium phosphate and low dose gamma irradiation suppress hepatocellular carcinoma by downregulating ROCK1 and VEGF gene expression.
Carcinoma, Hepatocellular
Complexes formation between insulin receptor and extracellular signal-regulated kinases ERKs.
Carcinoma, Hepatocellular
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Constancy of expression of the protein kinase A regulatory subunit R1 alpha in hepatoma cell lines of different phenotypes.
Carcinoma, Hepatocellular
Correction to Induction of Apoptosis by the Anthocyanidins through Regulation of Bcl-2 Gene and Activation of c-Jun N-Terminal Kinase Cascade in Hepatoma Cells.
Carcinoma, Hepatocellular
Correlation between loss of PTEN expression and PKB/AKT phosphorylation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Cross-species identification of in silico microsatellite biomarkers for genetic disease.
Carcinoma, Hepatocellular
Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20.
Carcinoma, Hepatocellular
Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Carcinoma, Hepatocellular
Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression.
Carcinoma, Hepatocellular
DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-?B pathway.
Carcinoma, Hepatocellular
DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line.
Carcinoma, Hepatocellular
Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.
Carcinoma, Hepatocellular
Downregulation of Raf-1 kinase inhibitory protein as a sorafenib resistance mechanism in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenib.
Carcinoma, Hepatocellular
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.
Carcinoma, Hepatocellular
Effect of adenosine 3':5'-cyclic monophosphate and inhibition of protein kinase A on heat sensitivity in H35 hepatoma cells.
Carcinoma, Hepatocellular
Effect of Glucuronidation on the Potential of Kaempferol To Inhibit Serine/Threonine Protein Kinases.
Carcinoma, Hepatocellular
Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Enhancing the clinical activity of sorafenib through dose escalation: rationale and current experience.
Carcinoma, Hepatocellular
Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation.
Carcinoma, Hepatocellular
Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors.
Carcinoma, Hepatocellular
Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression of Concern: Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma, Hepatocellular
Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4.
Carcinoma, Hepatocellular
Expression of Raf kinase inhibitor protein in human hepatoma tissues by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight methods.
Carcinoma, Hepatocellular
FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.
Carcinoma, Hepatocellular
Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings.
Carcinoma, Hepatocellular
Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor-alpha/cycloheximide-induced apoptosis by regulating protein kinase B levels.
Carcinoma, Hepatocellular
Frequent beta-catenin aberration in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation.
Carcinoma, Hepatocellular
Genetic screen identifies suppressor of morphogenesis in genitalia-1 (SMG-1) as a modulator of sorafenib resistance in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation.
Carcinoma, Hepatocellular
Glycogen synthase kinase-3beta negatively regulates group IIA phospholipase A2 expression in human aortic smooth muscle and HepG2 hepatoma cells.
Carcinoma, Hepatocellular
Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular carcinoma.
Carcinoma, Hepatocellular
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
Carcinoma, Hepatocellular
h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells.
Carcinoma, Hepatocellular
Heat shock, protein synthesis and ribosomal protein S6 phosphorylation in vitro in Yoshida AH 130 ascites hepatoma cells.
Carcinoma, Hepatocellular
High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer.
Carcinoma, Hepatocellular
Higher expression of A-kinase anchoring-protein 1 predicts poor prognosis in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Higher tumor protein kinase D1 correlates with increased tumor size, BCLC stage, CA199 level, AFP level and worse overall survival in hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
Carcinoma, Hepatocellular
HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1?.
Carcinoma, Hepatocellular
Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.
Carcinoma, Hepatocellular
Human sulfatase-1 inhibits the migration and proliferation of SMMC-7721 hepatocellular carcinoma cells by downregulating the growth factor signaling.
Carcinoma, Hepatocellular
Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.
Carcinoma, Hepatocellular
IC261 suppresses progression of hepatocellular carcinoma in a casein kinase 1 ?/? independent manner.
Carcinoma, Hepatocellular
Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Identification of the Amino Acids 300-600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573.
Carcinoma, Hepatocellular
Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.
Carcinoma, Hepatocellular
Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.
Carcinoma, Hepatocellular
Inhibition of exendin-4-induced steatosis by protein kinase A in cultured HepG2 human hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Carcinoma, Hepatocellular
Inhibition of GSK-3? activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling.
Carcinoma, Hepatocellular
Inhibition of Raf-1 kinase expression abolishes insulin stimulation of DNA synthesis in H4IIE hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of the JNK signaling pathway increases sensitivity of hepatocellular carcinoma cells to cisplatin by down-regulating expression of P-glycoprotein.
Carcinoma, Hepatocellular
Insulin action inhibits insulin-like growth factor-II (IGF-II) receptor phosphorylation in H-35 hepatoma cells. IGF-II receptors isolated from insulin-treated cells exhibit enhanced in vitro phosphorylation by casein kinase II.
Carcinoma, Hepatocellular
Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide.
Carcinoma, Hepatocellular
Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells.
Carcinoma, Hepatocellular
Interleukin-1 regulation of corticotropin-releasing factor (CRF), glucocorticoid receptor, c-fos and c-jun messenger RNA in the NPLC-KC cell line.
Carcinoma, Hepatocellular
Interleukin-33/ST2 Signaling Promotes Hepatocellular Carcinoma Cell Stemness Expansion Through Activating c-Jun N-terminal Kinase Pathway.
Carcinoma, Hepatocellular
Involvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Involvement of 3',5'-cyclic adenosine monophosphate regulatory element binding protein (CREB) in both basal and hormone-mediated expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene.
Carcinoma, Hepatocellular
IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.
Carcinoma, Hepatocellular
Isolation of a complementary DNA encoding the catalytic subunit of protein kinase A and studies on the expression of this sequence in rat hepatomas and regenerating liver.
Carcinoma, Hepatocellular
Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells.
Carcinoma, Hepatocellular
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.
Carcinoma, Hepatocellular
LINC00339 regulates ROCK1 by miR-152 to promote cell proliferation and migration in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A.
Carcinoma, Hepatocellular
Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
lncRNA TINCR sponges miR-214-5p to upregulate ROCK1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Long non-coding RNA linc-ITGB1 promotes cell proliferation, migration and invasion in human hepatoma carcinoma by upregulating ROCK1.
Carcinoma, Hepatocellular
Long noncoding RNA AURKAPS1 potentiates malignant hepatocellular carcinoma progression by regulating miR-142, miR-155 and miR-182.
Carcinoma, Hepatocellular
Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling.
Carcinoma, Hepatocellular
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells.
Carcinoma, Hepatocellular
Low cytoplasmic casein kinase 1 epsilon expression predicts poor prognosis in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
MEK/ERK pathway is positively involved in hypoxia-induced vasculogenic mimicry formation in hepatocellular carcinoma which is regulated negatively by protein kinase A.
Carcinoma, Hepatocellular
Methylation of the ataxia telangiectasia mutated gene (ATM) promoter as a radiotherapy outcome biomarker in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
microRNA-148a-3p enhances the effects of sevoflurane on hepatocellular carcinoma cell progression via ROCK1 repression.
Carcinoma, Hepatocellular
MicroRNA-26b-5p enhances T cell responses by targeting PIM-2 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MiR-199a/b-5p inhibits hepatocellular carcinoma progression by post-transcriptionally suppressing ROCK1.
Carcinoma, Hepatocellular
MiR-335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3-Kinase/Akt Serine/Threonine Kinase and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Neurotensin as a source of cyclic AMP and co-mitogen in fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3'-kinase/Akt signaling.
Carcinoma, Hepatocellular
NUCKS1 Acts as a Promising Novel Biomarker for the Prognosis of Patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma.
Carcinoma, Hepatocellular
Overexpression of PEMT2 downregulates the PI3K/Akt signaling pathway in rat hepatoma cells.
Carcinoma, Hepatocellular
Participation of a MEK-independent pathway in MAP kinase activation and modulation of cell growth in mouse hepatoma cell lines.
Carcinoma, Hepatocellular
Perfluorooctane sulfonate-induced insulin resistance is mediated by protein kinase B pathway.
Carcinoma, Hepatocellular
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Phosphorylation of hepatic AMP-activated protein kinase and liver kinase B1 is increased after a single oral dose of green tea extract to mice.
Carcinoma, Hepatocellular
Phosphorylation of isolated plasma membranes of AH-66 hepatoma ascites cells by casein kinase 1.
Carcinoma, Hepatocellular
Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Pim-2 Activates API-5 to Inhibit the Apoptosis of Hepatocellular Carcinoma Cells Through NF-kappaB Pathway.
Carcinoma, Hepatocellular
Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.
Carcinoma, Hepatocellular
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma, Hepatocellular
Prognostic significance of death-associated protein-kinase expression in hepatocellular carcinomas.
Carcinoma, Hepatocellular
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Carcinoma, Hepatocellular
Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo.
Carcinoma, Hepatocellular
Protein kinase D2 contributes to TNF-?-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3?/?-catenin pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Protein synthesis, ribosomal protein S6 phosphorylation in vitro and the effects of amiloride: SDS gel electrophoresis studies in the Yoshida ascites tumor (AH 130) grown in vivo.
Carcinoma, Hepatocellular
Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds.
Carcinoma, Hepatocellular
Quantitative Proteomics Reveals That the Inhibition of Na(+)/K(+)-ATPase Activity Affects S-Phase Progression Leading to a Chromosome Segregation Disorder by Attenuating the Aurora A Function in Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Hepatocellular
Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Rat primary hepatocytes and H4 hepatoma cells display differential sensitivity to cyclic AMP at the level of expression of tyrosine aminotransferase.
Carcinoma, Hepatocellular
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Carcinoma, Hepatocellular
Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.
Carcinoma, Hepatocellular
Regulation of insulin receptor kinase by multisite phosphorylation.
Carcinoma, Hepatocellular
Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect.
Carcinoma, Hepatocellular
Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Retraction Note: lncRNA TINCR sponges miR-214-5p to upregulate ROCK1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
Carcinoma, Hepatocellular
Rock2 promotes the invasion and metastasis of hepatocellular carcinoma by modifying MMP2 ubiquitination and degradation.
Carcinoma, Hepatocellular
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
Carcinoma, Hepatocellular
Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development.
Carcinoma, Hepatocellular
Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis.
Carcinoma, Hepatocellular
Role of MAP kinases and their cross-talk in TGF-beta1-induced apoptosis in FaO rat hepatoma cell line.
Carcinoma, Hepatocellular
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma, Hepatocellular
Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Selection of patients with hepatocellular carcinoma for sorafenib.
Carcinoma, Hepatocellular
Serine/Threonine Kinase Pim-2 Promotes Liver Tumorigenesis Induction Through Mediating Survival and Preventing Apoptosis of Liver Cell.
Carcinoma, Hepatocellular
SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3?/?-catenin signaling in HCC cells.
Carcinoma, Hepatocellular
Significant and Durable Clinical Response to Sorafenib and Radiation Therapy for a Patient With Stage IV Hepatocellular Carcinoma and LRRK2 Mutation.
Carcinoma, Hepatocellular
Silencing of 14-3-3? over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium.
Carcinoma, Hepatocellular
Sorafenib in advanced hepatocellular carcinoma: current status and future perspectives.
Carcinoma, Hepatocellular
Sorafenib inhibits migration and invasion of hepatocellular carcinoma cells through suppression of matrix metalloproteinase expression.
Carcinoma, Hepatocellular
Sorafenib inhibits the hepatocyte growth factor-mediated epithelial mesenchymal transition in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/?-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.
Carcinoma, Hepatocellular
Sphingoid bases from sea cucumber induce apoptosis in human hepatoma HepG2 cells through p-AKT and DR5.
Carcinoma, Hepatocellular
Stable knockdown of protein kinase CK2-alpha (CK2?) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells.
Carcinoma, Hepatocellular
STAT3 and beta-catenin signaling pathway may affect GSK-3beta expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
STK33 promotes hepatocellular carcinoma through binding to c-Myc.
Carcinoma, Hepatocellular
Structures of the PKA RI? Holoenzyme with the FLHCC Driver J-PKAc? or Wild-Type PKAc?.
Carcinoma, Hepatocellular
STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
Carcinoma, Hepatocellular
Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer.
Carcinoma, Hepatocellular
Targeted Gene Silencing BRAF Synergized Photothermal Effect Inhibits Hepatoma Cell Growth Using New GAL-GNR-siBRAF Nanosystem.
Carcinoma, Hepatocellular
Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel.
Carcinoma, Hepatocellular
Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.
Carcinoma, Hepatocellular
The alpha-isoform of the CCAAT/enhancer-binding protein is required for mediating cAMP responsiveness of the phosphoenolpyruvate carboxykinase promoter in hepatoma cells.
Carcinoma, Hepatocellular
The effects of urotensin II on migration and invasion are mediated by NADPH oxidase-derived reactive oxygen species through the c-Jun N-terminal kinase pathway in human hepatoma cells.
Carcinoma, Hepatocellular
The ménage à trois of autophagy, lipid droplets and liver disease.
Carcinoma, Hepatocellular
The phosphorylation of SEPT2 on Ser218 by casein kinase 2 is important to hepatoma carcinoma cell proliferation.
Carcinoma, Hepatocellular
The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells.
Carcinoma, Hepatocellular
Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-?1 /Smad2/3 pathway.
Carcinoma, Hepatocellular
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Transforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells.
Carcinoma, Hepatocellular
TRB3 reverses chemotherapy resistance and mediates crosstalk between endoplasmic reticulum stress and AKT signaling pathways in MHCC97H human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Tumor DNA-dependent protein kinase catalytic subunit expression is associated with hepatitis B surface antigen status and tumor progression in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Carcinoma, Hepatocellular
Upregulation of 14-3-3 eta in chronic liver fluke infection is a potential diagnostic marker of cholangiocarcinoma.
Carcinoma, Hepatocellular
Upregulation of Stress-Induced Protein Kinase CK1 Delta is associated with a Poor Prognosis for patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation.
Carcinoma, Hepatocellular
VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin.
Carcinoma, Hepatocellular
Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.
Carcinoma, Hepatocellular
ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line.
Carcinoma, Hepatocellular
[Expression of Pim-2 in normal liver and hepatocellular carcinoma tissues]
Carcinoma, Hepatocellular
[Expressions of Raf-1 kinase, phosphorylated mitogen extracellular kinase 1, and phosphorylated extracellular signal-regulated protein kinase 1/2 in hepatocellular carcinoma and their relationship with prognosis]
Carcinoma, Hepatocellular
[Knockdown of DNA-PKcs inhibits cell cycle and its mechanism of drug-resistant Bel7402/5-Fu hepatocellular carcinoma cells].
Carcinoma, Hepatocellular
[Preliminary study of dihydroartemisin in inhibiting invasion and metastasis of hepatoma cells].
Carcinoma, Hepatocellular
[Protein kinases and phospholipids in human hepatocellular carcinoma]
Carcinoma, Hepatocellular
[Serum-and-glucocorticoid-inducible-kinase-2 is overexpressed and mediates glycogen synthase kinase-3?/ ?-catenin signal transduction in hepatocellular carcinoma].
Carcinoma, Hepatocellular
[The effect and clinical significance of methylation of 14-3-3 sigma gene in hepatitis B virus-related hepatocellular carcinoma]
Carcinoma, Hepatocellular
[The role and significance of Wnt/beta-catenin signaling pathway regulating the signaling molecules in hepatocellular carcinoma.].
Carcinoma, Intraductal, Noninfiltrating
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling.
Carcinoma, Intraductal, Noninfiltrating
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Carcinoma, Intraductal, Noninfiltrating
Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis.
Carcinoma, Intraductal, Noninfiltrating
Promoter hypermethylation in ductal carcinoma in situ of the male breast.
Carcinoma, Large Cell
Correlation between STK33 and the pathology and prognosis of lung cancer.
Carcinoma, Large Cell
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Carcinoma, Lewis Lung
Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells.
Carcinoma, Lewis Lung
Activation of the protein kinase a signal transduction pathway by granulocyte-macrophage colony-stimulating factor or by genetic manipulation reduces cytoskeletal organization in Lewis lung carcinoma variants.
Carcinoma, Lewis Lung
Granulocyte-macrophage colony-stimulating factor stimulates the metastatic properties of Lewis lung carcinoma cells through a protein kinase A signal-transduction pathway.
Carcinoma, Lewis Lung
Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis.
Carcinoma, Lewis Lung
Protein phosphatases-1 and -2A regulate tumor cell migration, invasion and cytoskeletal organization.
Carcinoma, Lewis Lung
Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A.
Carcinoma, Lewis Lung
Regulation of protein kinase A activation and prostaglandin E2-stimulated migration of Lewis lung carcinoma clones.
Carcinoma, Lewis Lung
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Carcinoma, Lewis Lung
Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A.
Carcinoma, Lobular
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer.
Carcinoma, Lobular
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Carcinoma, Medullary
STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon.
Carcinoma, Mucoepidermoid
EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas.
Carcinoma, Mucoepidermoid
Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.
Carcinoma, Neuroendocrine
Durable response to combination radiotherapy and immunotherapy in EP-resistant lung large-cell neuroendocrine carcinoma with B2M and STK11 mutations: a case report.
Carcinoma, Non-Small-Cell Lung
?-Catulin drives metastasis by activating ILK and driving an ?v?3 integrin signaling axis.
Carcinoma, Non-Small-Cell Lung
A detailed smoking history and determination of MYC status predict response to checkpoint inhibitors in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
A p38?-Selective Chemosensor for use in Unfractionated Cell Lysates.
Carcinoma, Non-Small-Cell Lung
A randomized, phase 2 evaluation of the CHK1 inhibitor, LY2603618, administered in combination with pemetrexed and cisplatin in patients with advanced nonsquamous non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens.
Carcinoma, Non-Small-Cell Lung
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
ANXA1-GSK3? interaction and its involvement in NSCLC metastasis.
Carcinoma, Non-Small-Cell Lung
Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Association of EGFR and KRAS mutations with expression of p-AKT, DR5 and DcR1 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy.
Carcinoma, Non-Small-Cell Lung
Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Association of Tumor Protein p53 and Ataxia-Telangiectasia Mutated Comutation With Response to Immune Checkpoint Inhibitors and Mortality in Patients With Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy.
Carcinoma, Non-Small-Cell Lung
Aurora A, aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
cAMP signaling increases histone deacetylase 8 expression via the Epac2-Rap1A-Akt pathway in H1299 lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.
Carcinoma, Non-Small-Cell Lung
Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPK? signaling in STK11 mutant lung cancer.
Carcinoma, Non-Small-Cell Lung
Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines.
Carcinoma, Non-Small-Cell Lung
Elevated expression of G3BP1 associates with YB1 and p-AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection.
Carcinoma, Non-Small-Cell Lung
EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells.
Carcinoma, Non-Small-Cell Lung
Evading the STING: LKB1 Loss Leads to STING Silencing and Immune Escape in KRAS-Mutant Lung Cancers.
Carcinoma, Non-Small-Cell Lung
Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2.
Carcinoma, Non-Small-Cell Lung
Expression of phosphorylated mTOR and its clinical significances in small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Frequent down-regulation of pim-1 mRNA expression in non-small cell lung cancer is associated with lymph node metastases.
Carcinoma, Non-Small-Cell Lung
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated.
Carcinoma, Non-Small-Cell Lung
Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.
Carcinoma, Non-Small-Cell Lung
Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.
Carcinoma, Non-Small-Cell Lung
GSK-3? inhibits autophagy and enhances radiosensitivity in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN.
Carcinoma, Non-Small-Cell Lung
Inhibition of c-Jun N-terminal kinase signaling increased apoptosis and prevented the emergence of ALK-TKI-tolerant cells in ALK-rearranged non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Inhibition of protein kinase CK2 sensitizes non-small cell lung cancer cells to cisplatin via upregulation of PML.
Carcinoma, Non-Small-Cell Lung
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Interaction of ribosomal protein L22 with casein kinase 2?: a novel mechanism for understanding the biology of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway.
Carcinoma, Non-Small-Cell Lung
Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells.
Carcinoma, Non-Small-Cell Lung
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Carcinoma, Non-Small-Cell Lung
Knocking Down Nucleolin Expression Enhances the Radiosensitivity of Non-Small Cell Lung Cancer by Influencing DNA-PKcs Activity.
Carcinoma, Non-Small-Cell Lung
Kruppel-like factor 4 inhibits non-small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-?1-meidated ERK/JNK/NF-?B signaling pathways.
Carcinoma, Non-Small-Cell Lung
LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.
Carcinoma, Non-Small-Cell Lung
Long duration of immunotherapy in a STK11 mutated/KRAS wild-type non-small cell lung cancer patient.
Carcinoma, Non-Small-Cell Lung
MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
MicroRNA-137-regulated AKT serine/threonine kinase 2 inhibits tumor growth and sensitizes cisplatin in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.
Carcinoma, Non-Small-Cell Lung
miR-193a-3p inhibition of the Slug activator PAK4 suppresses non-small cell lung cancer aggressiveness via the p53/Slug/L1CAM pathway.
Carcinoma, Non-Small-Cell Lung
miR-335-5p inhibits TGF-?1-induced epithelial-mesenchymal transition in non-small cell lung cancer via ROCK1.
Carcinoma, Non-Small-Cell Lung
miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression.
Carcinoma, Non-Small-Cell Lung
Multiple primary malignant neoplasms: A case report and literature review.
Carcinoma, Non-Small-Cell Lung
Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11.
Carcinoma, Non-Small-Cell Lung
Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Carcinoma, Non-Small-Cell Lung
Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue array.
Carcinoma, Non-Small-Cell Lung
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion.
Carcinoma, Non-Small-Cell Lung
PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
PIM1-activated PRAS40 regulates radioresistance in non-small cell lung cancer cells through interplay with FOXO3a, 14-3-3 and protein phosphatases.
Carcinoma, Non-Small-Cell Lung
Primary Resistance to Immune Checkpoint Blockade in an STK11/TP53/KRAS-Mutant Lung Adenocarcinoma with High PD-L1 Expression.
Carcinoma, Non-Small-Cell Lung
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of nuclear or cytoplasmic nucleolin expression in human non-small cell lung cancer and its relationship with DNA-PKcs.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: A meta-analysis.
Carcinoma, Non-Small-Cell Lung
Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers.
Carcinoma, Non-Small-Cell Lung
Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Protein Kinase D1 Is Increased in Tumor Tissue, Correlates With Advanced Tumor Features and Worse Prognosis of Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Non-Small-Cell Lung
Reduced RKIP expression levels are associated with frequent non-small cell lung cancer metastasis and STAT3 phosphorylation and activation.
Carcinoma, Non-Small-Cell Lung
Reduction of Raf Kinase Inhibitor Protein Expression is Associated with Lymph Node Metastasis in Resectable Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
Carcinoma, Non-Small-Cell Lung
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Carcinoma, Non-Small-Cell Lung
ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
Carcinoma, Non-Small-Cell Lung
Role of next generation sequencing-based liquid biopsy in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: impact of STK11, KRAS and TP53 mutations and co-mutations on outcome.
Carcinoma, Non-Small-Cell Lung
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma, Non-Small-Cell Lung
Selective expression and immunogenicity of the cancer/testis antigens SP17, AKAP4 and PTTG1 in non-small cell lung cancer: new candidates for active immunotherapy.
Carcinoma, Non-Small-Cell Lung
STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort.
Carcinoma, Non-Small-Cell Lung
STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling.
Carcinoma, Non-Small-Cell Lung
Survival analysis for non-squamous NSCLC patients harbored STK11 or KEAP1 mutation receiving atezolizumab.
Carcinoma, Non-Small-Cell Lung
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
Carcinoma, Non-Small-Cell Lung
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Carcinoma, Non-Small-Cell Lung
The effect of ionizing radiation on the subcellular localization and kinase activity of protein kinase CK2 in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The influence of STK11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review.
Carcinoma, Non-Small-Cell Lung
The role of the c-Jun N-terminal kinase 2-?-isoform in non-small cell lung carcinoma tumorigenesis.
Carcinoma, Non-Small-Cell Lung
Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
WEE1 Kinase Inhibitor AZD1775 Has Preclinical Efficacy in LKB1-Deficient Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines.]
Carcinoma, Non-Small-Cell Lung
[Correlation of P27 expression and localization to phosphorylated AKT in non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Expression and clinical significance of Ku70, Ku80 and DNA-PKcs proteins in patients with stageI-II non-small cell lung cancer by tissue microarray.]
Carcinoma, Non-Small-Cell Lung
[Prognostic value of combined expression of Aurora A, p53 and p21 WAF1 in patients after curative resection of non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Carcinoma, Non-Small-Cell Lung
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Carcinoma, Ovarian Epithelial
14-3-3 zeta protein secreted by tumor associated monocytes/macrophages from ascites of epithelial ovarian cancer patients.
Carcinoma, Ovarian Epithelial
A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.
Carcinoma, Ovarian Epithelial
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Carcinoma, Ovarian Epithelial
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Carcinoma, Ovarian Epithelial
BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers.
Carcinoma, Ovarian Epithelial
Casein Kinase 1 Delta Regulates Cell Proliferation, Response to Chemotherapy and Migration in Human Ovarian Cancer Cells.
Carcinoma, Ovarian Epithelial
Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines.
Carcinoma, Ovarian Epithelial
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.
Carcinoma, Ovarian Epithelial
Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature.
Carcinoma, Ovarian Epithelial
Clinicopathological and biological significance of aberrant activation of glycogen synthase kinase-3 in ovarian cancer.
Carcinoma, Ovarian Epithelial
Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.
Carcinoma, Ovarian Epithelial
Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients.
Carcinoma, Ovarian Epithelial
Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
Carcinoma, Ovarian Epithelial
Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib Via Regulation of Rad-51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells.
Carcinoma, Ovarian Epithelial
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
Carcinoma, Ovarian Epithelial
Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells.
Carcinoma, Ovarian Epithelial
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Investigating the clinical potential for 14-3-3 zeta protein to serve as a biomarker for epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
LC-MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker.
Carcinoma, Ovarian Epithelial
Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity.
Carcinoma, Ovarian Epithelial
TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2? as a therapeutic target.
Carcinoma, Ovarian Epithelial
[Expression of phosphorylated protein kinase B and PTEN protein in ovarian epithelial cancer]
Carcinoma, Pancreatic Ductal
Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.
Carcinoma, Papillary
14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.
Carcinoma, Papillary
Caveolin-1 and 14-3-3 sigma expression in follicular variant of thyroid papillary carcinoma.
Carcinoma, Papillary
Expression of down stream molecules of RET (p-ERK, p-p38 MAPK, p-JNK and p-AKT) in papillary thyroid carcinomas.
Carcinoma, Papillary
The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.
Carcinoma, Papillary
[BRAF gene mutation in the natural history of papillary thyroid carcinoma: diagnostic and prognostic implications].
Carcinoma, Renal Cell
14-3-3 protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid.
Carcinoma, Renal Cell
A-kinase interacting protein 1 high expression correlates with advanced tumor stage and poor overall survival in surgical patients with clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma, Renal Cell
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer.
Carcinoma, Renal Cell
Beta2-microglobulin promotes the growth of human renal cell carcinoma through the activation of the protein kinase A, cyclic AMP-responsive element-binding protein, and vascular endothelial growth factor axis.
Carcinoma, Renal Cell
Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma.
Carcinoma, Renal Cell
Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Cyclin-Dependent Kinase Inhibitor BMI-1026 Induces Apoptosis by Downregulating Mcl-1 (L) and c-FLIP (L) and Inactivating p-Akt in Human Renal Carcinoma Cells.
Carcinoma, Renal Cell
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Carcinoma, Renal Cell
Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma - no evidence for an overexpression of protein kinase B.
Carcinoma, Renal Cell
Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth.
Carcinoma, Renal Cell
Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways.
Carcinoma, Renal Cell
Editorial comment on: Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma, Renal Cell
Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.
Carcinoma, Renal Cell
G Protein Alpha S Subunit Promotes Cell Proliferation of Renal Cell Carcinoma with Involvement of Protein Kinase A Signaling.
Carcinoma, Renal Cell
Ghrelin Upregulates Oncogenic Aurora A to Promote Renal Cell Carcinoma Invasion.
Carcinoma, Renal Cell
Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.
Carcinoma, Renal Cell
GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Carcinoma, Renal Cell
GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC).
Carcinoma, Renal Cell
Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3.
Carcinoma, Renal Cell
Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis.
Carcinoma, Renal Cell
Incremental Expression of 14-3-3 Protein Beta/Alpha in Urine Correlates with Advanced Stage and Poor Survival in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
LRRK2 is a candidate prognostic biomarker for clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Methylation of STK11 promoter is a risk factor for tumor stage and survival in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma.
Carcinoma, Renal Cell
Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation.
Carcinoma, Renal Cell
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Carcinoma, Renal Cell
p-AKT overexpression in primary renal cell carcinomas and their metastases.
Carcinoma, Renal Cell
p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Phase I trial of everolimus plus sorafenib for patients with advanced renal cell cancer.
Carcinoma, Renal Cell
Pyrvinium Sensitizes Clear Cell Renal Cell Carcinoma Response to Chemotherapy Via Casein Kinase 1?-Dependent Inhibition of Wnt/?-Catenin.
Carcinoma, Renal Cell
Quantitative protein expression profiling of 14-3-3 isoforms in human renal carcinoma shows 14-3-3 epsilon is involved in limitedly increasing renal cell proliferation.
Carcinoma, Renal Cell
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma, Renal Cell
Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3?.
Carcinoma, Renal Cell
Recent advances in the research and development of RAF kinase inhibitors.
Carcinoma, Renal Cell
Reduced expression of Raf-1 kinase inhibitory protein in renal cell carcinoma: a significant prognostic marker.
Carcinoma, Renal Cell
Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a?p-AKT-dependent manner.
Carcinoma, Renal Cell
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV.
Carcinoma, Renal Cell
RIalpha Influences Cellular Proliferation in Cancer Cells by Transporting RFC40 into the Nucleus.
Carcinoma, Renal Cell
Ribosomal s6 protein kinase 4: a prognostic factor for renal cell carcinoma.
Carcinoma, Renal Cell
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Carcinoma, Renal Cell
Sorafenib stimulates human skin type mast cell degranulation and maturation.
Carcinoma, Renal Cell
Sorafenib-associated remission of psoriasis in hypernephroma: case report.
Carcinoma, Renal Cell
The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.
Carcinoma, Renal Cell
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.
Carcinoma, Renal Cell
The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma, Renal Cell
The putative tumour suppressor microRNA-145, repressed by c-jun, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1.
Carcinoma, Renal Cell
Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1.
Carcinoma, Renal Cell
VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinoma.
Carcinoma, Small Cell
Correlation between STK33 and the pathology and prognosis of lung cancer.
Carcinoma, Small Cell
Expression of phosphorylated Akt in patients with small cell carcinoma of the lung indicates good prognosis.
Carcinoma, Small Cell
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma, Squamous Cell
14-3-3? silencing retards tongue squamous cell carcinoma progression by inhibiting cell survival and migration.
Carcinoma, Squamous Cell
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Carcinoma, Squamous Cell
A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Carcinoma, Squamous Cell
Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.
Carcinoma, Squamous Cell
Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Antisense oligonucleotides against protein kinase CK2-alpha inhibit growth of squamous cell carcinoma of the head and neck in vitro.
Carcinoma, Squamous Cell
Association of elevated protein kinase CK2 activity with aggressive behavior of squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells.
Carcinoma, Squamous Cell
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Carcinoma, Squamous Cell
Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation.
Carcinoma, Squamous Cell
Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung.
Carcinoma, Squamous Cell
Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer.
Carcinoma, Squamous Cell
Clinicopathological features and prognostic implications of Raf kinase inhibitor protein downregulation in tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
Clinicopathological significance of ribosomal protein S6 kinase A6 in lung squamous cell carcinoma: an immunohistochemical and RNA-seq study.
Carcinoma, Squamous Cell
Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia.
Carcinoma, Squamous Cell
Constitutive modulation of Raf-1 protein kinase is associated with differential gene expression of several known and unknown genes.
Carcinoma, Squamous Cell
Correlation between STK33 and the pathology and prognosis of lung cancer.
Carcinoma, Squamous Cell
Correlation of constitutive activation of raf-1 with morphological transformation and abrogation of tyrosine phosphorylation of distinct sets of proteins in human squamous carcinoma cells.
Carcinoma, Squamous Cell
CUL2 and STK11 as novel response-predictive genes for neoadjuvant radiochemotherapy in esophageal cancer.
Carcinoma, Squamous Cell
Decreased expression of 14-3-3 ?, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer.
Carcinoma, Squamous Cell
Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract.
Carcinoma, Squamous Cell
Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-?1/Smad Signaling Pathway.
Carcinoma, Squamous Cell
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival.
Carcinoma, Squamous Cell
Effect of DJ-1 overexpression on the proliferation, apoptosis, invasion and migration of laryngeal squamous cell carcinoma SNU-46 cells through PI3K/AKT/mTOR.
Carcinoma, Squamous Cell
Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Carcinoma, Squamous Cell
Evaluation of Prexasertib, a Checkpoint Kinase 1 Inhibitor, in a Phase Ib Study of Patients with Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats.
Carcinoma, Squamous Cell
Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma.
Carcinoma, Squamous Cell
Expression and Significance of RKIP and E-cadherin in Lung Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Carcinoma, Squamous Cell
Expression of cyclin D1 and GSK-3beta and their predictive value of prognosis in squamous cell carcinomas of the tongue.
Carcinoma, Squamous Cell
Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis.
Carcinoma, Squamous Cell
Expression of protein tyrosine kinases in head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
Carcinoma, Squamous Cell
Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
Carcinoma, Squamous Cell
Functional characterization of transforming growth factor beta type II receptor mutants in human cancer.
Carcinoma, Squamous Cell
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Carcinoma, Squamous Cell
Histamine inhibits the production of interferon-induced protein of 10 kDa in human squamous cell carcinoma and melanoma.
Carcinoma, Squamous Cell
Identificating 14-3-3 sigma as a lymph node metastasis-related protein in human lung squamous carcinoma.
Carcinoma, Squamous Cell
Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.
Carcinoma, Squamous Cell
Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes.
Carcinoma, Squamous Cell
Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells.
Carcinoma, Squamous Cell
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Carcinoma, Squamous Cell
Interferon-?-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway.
Carcinoma, Squamous Cell
Keratin 17 is co-expressed with 14-3-3 sigma in oral carcinoma in situ and squamous cell carcinoma and modulates cell proliferation and size but not cell migration.
Carcinoma, Squamous Cell
KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
Carcinoma, Squamous Cell
lncRNA HAND2-AS1 inhibits cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and negative cervical squamous cell carcinoma.
Carcinoma, Squamous Cell
Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1.
Carcinoma, Squamous Cell
MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer.
Carcinoma, Squamous Cell
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.
Carcinoma, Squamous Cell
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
Carcinoma, Squamous Cell
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.
Carcinoma, Squamous Cell
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Carcinoma, Squamous Cell
Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.
Carcinoma, Squamous Cell
Overexpression of phosphorylated nuclear factor-kappa B in tonsillar squamous cell carcinoma and high-grade dysplasia is associated with poor prognosis.
Carcinoma, Squamous Cell
p63 regulates growth of esophageal squamous carcinoma cells via the Akt signaling pathway.
Carcinoma, Squamous Cell
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Carcinoma, Squamous Cell
PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations.
Carcinoma, Squamous Cell
Phospho-?Np63?-dependent regulation of autophagic signaling through transcription and micro-RNA modulation.
Carcinoma, Squamous Cell
Phosphorylated p63 induces transcription of regulatory particle non ATP-ase subunit 13 and nitric oxide synthase-2 protein degradation.
Carcinoma, Squamous Cell
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Carcinoma, Squamous Cell
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma, Squamous Cell
Protein kinase C deficiency blocks recovery from agonist-induced desensitization.
Carcinoma, Squamous Cell
Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells.
Carcinoma, Squamous Cell
Proteome analysis in the clinical chemistry laboratory: myth or reality?
Carcinoma, Squamous Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Squamous Cell
Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma.
Carcinoma, Squamous Cell
Reversal effect of Raf-1/Mdr-1 siRNAs co-transfection on multidrug resistance in KBv200 cell line.
Carcinoma, Squamous Cell
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
Carcinoma, Squamous Cell
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Carcinoma, Squamous Cell
Targeting 14-3-3?-CDC25A interactions to trigger apoptotic cell death in skin cancer.
Carcinoma, Squamous Cell
The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.
Carcinoma, Squamous Cell
The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro.
Carcinoma, Squamous Cell
The Mammalian Target of Rapamycin-70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3? and ? are independent prognostic factors for these tumors.
Carcinoma, Squamous Cell
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Carcinoma, Squamous Cell
TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
[Diagnostic value of protein markers in plasma exosomes of lung squamous cell carcinoma].
Carcinoma, Squamous Cell
[Effects of salinomycin on proliferation and apoptosis of oral squamous cell carcinoma].
Carcinoma, Squamous Cell
[Role of protein kinase D1 in regulating the growth, apoptosis and drug sensitivity of oral squamous carcinoma cells].
Carcinoma, Squamous Cell
[The expressions and significance of CK2 in normal laryngeal mucosa, laryngeal precancerosis and laryngeal squamous cell carcinoma]
Carcinoma, Transitional Cell
Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c?Raf/MEK/ERK signaling pathway.
Carcinoma, Transitional Cell
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition.
Carcinoma, Transitional Cell
Hypermethylation-mediated partial transcriptional silencing of DAP-kinase gene in bladder cancer.
Carcinoma, Transitional Cell
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis.
Carcinoma, Transitional Cell
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
Carcinoma, Transitional Cell
Selective reovirus killing of bladder cancer in a co-culture spheroid model.
Carcinoma, Verrucous
Differential expression of ras signal transduction mediators in verrucous and squamous cell carcinomas of the upper aerodigestive tract.
Cardiac Conduction System Disease
Developmental changes in expression of myotonic dystrophy protein kinase in the rat central nervous system.
Cardiac Conduction System Disease
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Cardiomegaly
(-)-Epicatechin induces physiological cardiac growth by activation of the pi3k/akt pathway in mice.
Cardiomegaly
2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.
Cardiomegaly
A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy.
Cardiomegaly
A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy.
Cardiomegaly
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.
Cardiomegaly
Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats.
Cardiomegaly
Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts.
Cardiomegaly
AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol.
Cardiomegaly
Angiotensin II-induced cardiac hypertrophy is associated with different mitogen-activated protein kinase activation in normotensive and hypertensive mice.
Cardiomegaly
Angiotensin-(1-7) stimulates high atrial pacing-induced ANP secretion via Mas/PI3-kinase/Akt axis and Na+/H+ exchanger.
Cardiomegaly
Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways.
Cardiomegaly
Arrhythmogenic ?-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII.
Cardiomegaly
Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population.
Cardiomegaly
Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca²?-mediated calcineurin/NFATc3 and CaMKII signaling cascades.
Cardiomegaly
Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.
Cardiomegaly
Atorvastatin reverses cardiac remodeling possibly through regulation of Protein Kinase D/Myocyte Enhancer Factor 2D activation in spontaneously hypertensive rats.
Cardiomegaly
Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.
Cardiomegaly
Ca2+/calmodulin-dependent protein kinase II increases the susceptibility to the arrhythmogenic action potential alternans in spontaneously hypertensive rats.
Cardiomegaly
Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.
Cardiomegaly
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
Cardiomegaly
CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice.
Cardiomegaly
CaMKIIdelta orchestrates G protein coupled receptor and electric field stimulation-induced cardiomyocyte hypertrophy.
Cardiomegaly
Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca2+/Calmodulin-Dependent Protein Kinase II Signaling.
Cardiomegaly
Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway.
Cardiomegaly
Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription.
Cardiomegaly
Cardioprotection of an IK1 channel agonist on L-thyroxine induced rat ventricular remodeling.
Cardiomegaly
Carvedilol reverses cardiac insufficiency in AKAP5 knockout mice by normalizing the activities of calcineurin and CaMKII.
Cardiomegaly
Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.
Cardiomegaly
Caspase recruitment domain 6 protects against cardiac hypertrophy in response to pressure overload.
Cardiomegaly
Caveolae-specific activation loop between CaMKII and L-type Ca(2+) channel aggravates cardiac hypertrophy in ?1-adrenergic stimulation.
Cardiomegaly
Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy.
Cardiomegaly
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins.
Cardiomegaly
Control of histone H3 phosphorylation by CaMKII? in response to haemodynamic cardiac stress.
Cardiomegaly
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Cardiomegaly
Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages.
Cardiomegaly
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Cardiomegaly
Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy.
Cardiomegaly
Disparate Regulation of Signaling Proteins after Exercise and Myocardial Infarction.
Cardiomegaly
Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy.
Cardiomegaly
Distinct roles of calmodulin and Ca2+/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy.
Cardiomegaly
Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.
Cardiomegaly
DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.
Cardiomegaly
Early apoptosis in different models of cardiac hypertrophy induced by high renin-angiotensin system activity involves CaMKII.
Cardiomegaly
Effect of inhibition of glycogen synthase kinase-3 on cardiac hypertrophy during acute pressure overload.
Cardiomegaly
Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy.
Cardiomegaly
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.
Cardiomegaly
Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload
Cardiomegaly
Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload.
Cardiomegaly
Experimental antiarrhythmic targets: CaMKII inhibition - Ready for clinical evaluation?
Cardiomegaly
Expression of Ca2+/calmodulin-dependent protein kinase II delta-subunit isoforms in rats with hypertensive cardiac hypertrophy.
Cardiomegaly
Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis.
Cardiomegaly
Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload.
Cardiomegaly
Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol.
Cardiomegaly
Glycogen synthase kinase-3beta is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1.
Cardiomegaly
Glycogen synthase kinase-3beta negatively regulates TGF-beta1 and Angiotensin II-mediated cellular activity through interaction with Smad3.
Cardiomegaly
Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins.
Cardiomegaly
Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.
Cardiomegaly
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Cardiomegaly
Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.
Cardiomegaly
Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes.
Cardiomegaly
Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor.
Cardiomegaly
Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats.
Cardiomegaly
Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid.
Cardiomegaly
Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy.
Cardiomegaly
Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling.
Cardiomegaly
Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition.
Cardiomegaly
LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII.
Cardiomegaly
mAKAP? signalosomes - A nodal regulator of gene transcription associated with pathological cardiac remodeling.
Cardiomegaly
MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
Cardiomegaly
miR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1).
Cardiomegaly
MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction.
Cardiomegaly
Na+/H+ exchanger isoform 1 induced cardiomyocyte hypertrophy involves activation of p90 ribosomal s6 kinase.
Cardiomegaly
Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy.
Cardiomegaly
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Cardiomegaly
Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.
Cardiomegaly
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
Cardiomegaly
Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.
Cardiomegaly
Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.
Cardiomegaly
PKD knockdown inhibits pressure overload-induced cardiac hypertrophy by promoting autophagy via AKT/mTOR pathway.
Cardiomegaly
Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.
Cardiomegaly
Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload.
Cardiomegaly
Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation.
Cardiomegaly
ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice.
Cardiomegaly
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure.
Cardiomegaly
Roles of cyclooxygenase-2 and phosphorylated Akt (Thr308) in cardiac hypertrophy regression mediated by left-ventricular unloading.
Cardiomegaly
Roles of Glycogen Synthase Kinase-3 (GSK-3) in Cardiac Development and Heart Disease.
Cardiomegaly
Simvastatin Protects Heart from Pressure Overload Injury by Inhibiting Excessive Autophagy.
Cardiomegaly
Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy.
Cardiomegaly
Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy.
Cardiomegaly
Small-conductance Ca2+-activated K+ current is upregulated via the phosphorylation of CaMKII in cardiac hypertrophy from spontaneously hypertensive rats.
Cardiomegaly
Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes.
Cardiomegaly
Sustained increased CaMKII phosphorylation is involved in the impaired regression of isoproterenol-induced cardiac hypertrophy in rats.
Cardiomegaly
Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
Cardiomegaly
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis.
Cardiomegaly
Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy.
Cardiomegaly
TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells.
Cardiomegaly
The ?A isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway.
Cardiomegaly
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
Cardiomegaly
The combined inhibition of the CaMKII? and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
Cardiomegaly
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
Cardiomegaly
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.
Cardiomegaly
The Mammalian Ste20-like Kinase 2 (Mst2) Modulates Stress-induced Cardiac Hypertrophy.
Cardiomegaly
The role of protein kinase D (PKD) in intracellular nutrient sensing and regulation of adaptive responses to the obese environment.
Cardiomegaly
The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism.
Cardiomegaly
The Wnt/frizzled/GSK-3beta pathway: a novel therapeutic target for cardiac hypertrophy.
Cardiomegaly
Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation.
Cardiomegaly
Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes.
Cardiomegaly
Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.
Cardiomegaly
TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice.
Cardiomegaly
Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.
Cardiomegaly
Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.
Cardiomegaly
Urotensin II induction of adult cardiomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathway.
Cardiomegaly
Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways.
Cardiomegaly
ZAK? antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAK?.
Cardiomegaly
[Oxidative stress and calcium/calmodulin-dependent protein kinase II contribute to the development of sustained ? adrenergic receptor-stimulated cardiac hypertrophy in rats].
Cardiomegaly
[Role of glycogen synthase kinase-3beta in cardiac hypertrophy and cardiocyte apoptosis]
Cardiomyopathies
Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy.
Cardiomyopathies
Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-?B pathway.
Cardiomyopathies
Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy.
Cardiomyopathies
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.
Cardiomyopathies
Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.
Cardiomyopathies
Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein.
Cardiomyopathies
CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression.
Cardiomyopathies
CaMKII-?9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.
Cardiomyopathies
Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine.
Cardiomyopathies
Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling.
Cardiomyopathies
Cardioprotective role of GTS-21 by attenuating the TLR4/NF-?B pathway in streptozotocin-induced diabetic cardiomyopathy in rats.
Cardiomyopathies
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy.
Cardiomyopathies
Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.
Cardiomyopathies
Crosstalk between GSK-3?-actuated molecular cascades and myocardial physiology.
Cardiomyopathies
Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy.
Cardiomyopathies
Diminished Cardiac Fibrosis in Heart Failure is Associated with Altered Ventricular Arrhythmia Phenotype.
Cardiomyopathies
Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy.
Cardiomyopathies
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Cardiomyopathies
GRK5 Controls SAP97-Dependent Cardiotoxic ?1 Adrenergic Receptor-CaMKII Signaling in Heart Failure.
Cardiomyopathies
Huoxue Wentong Formula ameliorates myocardial infarction in rats through inhibiting CaMKII oxidation and phosphorylation.
Cardiomyopathies
Impaired angiotensin II-extracellular signal-regulated kinase signaling in failing human ventricular myocytes.
Cardiomyopathies
Inactivation of GSK-3{beta} by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage and remodeling.
Cardiomyopathies
Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.
Cardiomyopathies
Interaction of ?1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.
Cardiomyopathies
Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.
Cardiomyopathies
Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice.
Cardiomyopathies
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Cardiomyopathies
Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.
Cardiomyopathies
Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.
Cardiomyopathies
Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.
Cardiomyopathies
Quantitative proteomic analysis reveals high interference on protein expression of H9c2 cells activated with glucose and cardiotonic steroids.
Cardiomyopathies
Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.
Cardiomyopathies
The combined inhibition of the CaMKII? and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
Cardiomyopathy, Alcoholic
Valsartan inhibits RhoA-ROCK2-MYL pathway in rat model of alcoholic cardiomyopathy.
Cardiomyopathy, Dilated
2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation.
Cardiomyopathy, Dilated
2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation.
Cardiomyopathy, Dilated
Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy.
Cardiomyopathy, Dilated
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
Cardiomyopathy, Dilated
All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation.
Cardiomyopathy, Dilated
Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy.
Cardiomyopathy, Dilated
Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.
Cardiomyopathy, Dilated
Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation.
Cardiomyopathy, Dilated
Emerging Role for RBM20 and Its Splicing Substrates in Cardiac Function and Heart Failure.
Cardiomyopathy, Dilated
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.
Cardiomyopathy, Dilated
Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy.
Cardiomyopathy, Dilated
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.
Cardiomyopathy, Dilated
Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.
Cardiomyopathy, Dilated
NMR solution structure and topological orientation of monomeric phospholamban in dodecylphosphocholine micelles.
Cardiomyopathy, Dilated
Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.
Cardiomyopathy, Dilated
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.
Cardiomyopathy, Dilated
Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy.
Cardiomyopathy, Dilated
Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation.
Cardiomyopathy, Dilated
The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.
Cardiomyopathy, Dilated
The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics.
Cardiomyopathy, Dilated
The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.
Cardiomyopathy, Hypertrophic
Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C.
Cardiomyopathy, Hypertrophic
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.
Cardiomyopathy, Hypertrophic
Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice.
Cardiomyopathy, Hypertrophic
Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.
Cardiomyopathy, Hypertrophic
Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Cardiomyopathy, Hypertrophic
Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.
Cardiomyopathy, Hypertrophic
Selective phosphorylation of PKA targets after ?-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.
Cardiomyopathy, Restrictive
Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.
Cardiomyopathy, Restrictive
Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
Cardiomyopathy, Restrictive
Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
Cardiotoxicity
Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity.
Cardiotoxicity
CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression.
Cardiotoxicity
CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes.
Cardiotoxicity
Cardiotoxicity of sorafenib is mediated through elevation of ROS level and CaMKII activity and dysregulation of calcium homeostasis.
Cardiotoxicity
Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.
Cardiotoxicity
Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity.
Cardiotoxicity
Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin-dependent protein kinase II.
Cardiotoxicity
Investigation of the mechanism of the reduction of anthracycline-induced cardiotoxicity by Qishen Huanwu Capsule based on network pharmacology.
Cardiotoxicity
Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II.
Cardiovascular Diseases
A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases.
Cardiovascular Diseases
AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease.
Cardiovascular Diseases
An Overview of the Role of Calcium/Calmodulin-Dependent Protein Kinase in Cardiorenal Syndrome.
Cardiovascular Diseases
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Cardiovascular Diseases
Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway.
Cardiovascular Diseases
c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.
Cardiovascular Diseases
CaMKII: The molecular villain that aggravates cardiovascular disease.
Cardiovascular Diseases
CaMKII? post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes.
Cardiovascular Diseases
Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis.
Cardiovascular Diseases
Designing of the N-ethyl-4-(pyridin-4-yl)benzamide based potent ROCK1 inhibitors using docking, molecular dynamics, and 3D-QSAR.
Cardiovascular Diseases
DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis.
Cardiovascular Diseases
Effects of heterologous expression of human cyclic nucleotide Phosphodiesterase 3A (hPDE3A) on redox regulation in yeast.
Cardiovascular Diseases
Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors.
Cardiovascular Diseases
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Cardiovascular Diseases
Human muscle-specific A-kinase anchoring protein (mAKAP) polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/ PKA signaling.
Cardiovascular Diseases
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3?.
Cardiovascular Diseases
IGF-2R-G?q signalling and cardiac hypertrophy in the low birth weight lamb.
Cardiovascular Diseases
Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation.
Cardiovascular Diseases
Interaction of ?1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.
Cardiovascular Diseases
Intervention Mechanisms of Xinmailong Injection, a Periplaneta Americana Extract, on Cardiovascular Disease: A Systematic Review of Basic Researches.
Cardiovascular Diseases
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II.
Cardiovascular Diseases
Na(+)/K(+)-ATPase inhibition by ouabain induces CaMKII-dependent apoptosis in adult rat cardiac myocytes.
Cardiovascular Diseases
Oxidative CaMKII as a potential target for inflammatory disease (Review).
Cardiovascular Diseases
Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.
Cardiovascular Diseases
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.
Cardiovascular Diseases
Peptide Substrates for Rho-Associated Kinase 2 (Rho-Kinase 2/ROCK2).
Cardiovascular Diseases
Receptor-interacting protein 2 (RIP2) gene polymorphisms are associated with increased risk of subclinical atherosclerosis and clinical and metabolic parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican study.
Cardiovascular Diseases
Role of CaMKII in free fatty acid/hyperlipidemia-induced cardiac remodeling both in vitro and in vivo.
Cardiovascular Diseases
Scutellarin exerts its anti-hypertrophic effects via suppressing the Ca2+-mediated calcineurin and CaMKII signaling pathways.
Cardiovascular Diseases
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Cardiovascular Diseases
The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study.
Cardiovascular Diseases
The expression of microRNAs and exposure to environmental contaminants related to human health: a review.
Cardiovascular Diseases
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.
Cardiovascular Diseases
Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway.
Cardiovascular Diseases
Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological Sex.
Cardiovascular Diseases
ZYZ-803, a novel hydrogen sulfide-nitric oxide conjugated donor, promotes angiogenesis via cross-talk between STAT3 and CaMKII.
Carney Complex
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia.
Carney Complex
8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.
Carney Complex
A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.
Carney Complex
A Novel PRKAR1A Mutation Identified in a Patient with Isolated Primary Pigmented Nodular Adrenocortical Disease.
Carney Complex
A pleiomorphic GH pituitary adenoma from a Carney complex patient displays universal allelic loss at the protein kinase A regulatory subunit 1A (PRKARIA) locus.
Carney Complex
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Carney Complex
Anesthetic experiences of myxoma removal surgery in two patients with Carney complex -A report of two cases-.
Carney Complex
Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog.
Carney Complex
Carney complex and McCune Albright syndrome: An overview of clinical manifestations and human molecular genetics.
Carney Complex
Clinical genetics of multiple endocrine neoplasias, Carney complex and related syndromes.
Carney Complex
Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
Carney Complex
Frequent Phosphodiesterase 11A Gene (PDE11A) Defects in Patients with Carney Complex (CNC) Caused by PRKAR1A Mutations: PDE11A May Contribute to Adrenal and Testicular Tumors in CNC as a Modifier of the Phenotype.
Carney Complex
Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex.
Carney Complex
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
Carney Complex
Germline deletion and a somatic mutation of the PRKAR1A gene in a Carney complex-related pituitary adenoma.
Carney Complex
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Carney Complex
Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease!
Carney Complex
In Vitro Studies of Novel PRKAR1A Mutants that Extend the Predicted RI? Protein Sequence into the 3'-Untranslated Open Reading Frame: Proteasomal Degradation Leads to RI? Haploinsufficiency and Carney Complex.
Carney Complex
Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
Carney Complex
Knockdown of PRKAR1A, the Gene Responsible for Carney Complex, Interferes With Differentiation in Osteoblastic Cells.
Carney Complex
Melanotic nonpsammomatous trigeminal schwannoma as the first manifestation of Carney complex: case report.
Carney Complex
Melanotic Schwannoma of the Vulva: A Case Report and Review of the Literature.
Carney Complex
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Carney Complex
MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.
Carney Complex
Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas.
Carney Complex
Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.
Carney Complex
Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex.
Carney Complex
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.
Carney Complex
New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors.
Carney Complex
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Carney Complex
Pathology of the adrenal cortex: a reappraisal of the past 25 years focusing on adrenal cortical tumors.
Carney Complex
Primary pigmented nodular adrenocortical disease reveals insulin-like growth factor binding protein-2 regulation by protein kinase A.
Carney Complex
PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.
Carney Complex
PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes.
Carney Complex
PRKAR1A mutation causing pituitary-dependent Cushing disease in a patient with Carney complex.
Carney Complex
Protein kinase A and its role in human neoplasia: the Carney complex paradigm.
Carney Complex
Protein kinase A and tumorigenicity: the example of micronodular adrenocortical hyperplasia and Carney complex.
Carney Complex
Protein kinase A in Carney complex: a new example of cAMP pathway alteration in endocrine tumors.
Carney Complex
Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.
Carney Complex
Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
Carney Complex
The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
Carney Complex
The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis.
Carney Complex
[PRKAR1A gene mutations in two patients with myxoma syndrome (Carney complex)]
Carotid Artery Injuries
Tumor Suppressor Serine/Threonine Kinase LKB1 Expression, Not Kinase Activity, Increased in the Vascular Smooth Muscle Cells and Neointima in the Rat Carotid Artery Injury Model.
Cataract
Enhanced serum immunoglobulin G clearance in myotonic dystrophy-associated hypogammaglobulinemia: a case series and review of the literature.
Cataract
High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene.
Cataract
Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A.
Cell Transformation, Neoplastic
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Cell Transformation, Neoplastic
Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
Cell Transformation, Neoplastic
Long-term culture of human gingival keratinocyte progenitor cells by down-regulation of 14-3-3 sigma.
Cell Transformation, Neoplastic
Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta.
Cell Transformation, Neoplastic
Relationship between functional polymorphism in the Aurora A gene and susceptibility of hepatocellular carcinoma.
Central Nervous System Diseases
14-3-3 adaptor protein-protein interactions as therapeutic targets for CNS diseases.
Central Nervous System Diseases
14-3-3 protein in CSF: an early predictor of SIV CNS disease.
Central Nervous System Diseases
A unique type of GSK-3 inhibitor brings new opportunities to the clinic.
Central Nervous System Diseases
Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.
Central Nervous System Diseases
Control of JNK for an activation of NADPH oxidase in LPS-stimulated BV2 microglia.
Central Nervous System Diseases
Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.
Central Nervous System Diseases
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
Central Nervous System Diseases
Mechanism of delayed encephalopathy after acute carbon monoxide poisoning.
Central Nervous System Diseases
Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
Central Nervous System Diseases
Potential involvement of glycogen synthase kinase (GSK)-3? in a rat model of multiple sclerosis: evidenced by lithium treatment.
Central Nervous System Diseases
Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases.
Central Nervous System Diseases
RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L.
Central Nervous System Diseases
The Possible Involvement of Glycogen Synthase Kinase-3 (GSK-3) in Diabetes, Cancer and Central Nervous System Diseases.
Central Nervous System Infections
Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
Central Nervous System Infections
Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease.
Cerebellar Ataxia
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Cerebellar Ataxia
Cutaneous Granulomatosis and Class Switching Defect as a Presenting Sign in Ataxia-Telangiectasia: First Case from the National Iranian Registry and Review of the Literature.
Cerebellar Ataxia
Inner retinal dystrophy in a patient with biallelic sequence variants in BRAT1.
Cerebellar Ataxia
Late-onset autosomal recessive cerebellar ataxia and neuropathy with a novel splicing mutation in the ATM gene.
Cerebellar Diseases
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Cerebellar Diseases
A practical approach to avoiding iatrogenic Creutzfeldt-Jakob disease (CJD) from invasive instruments.
Cerebellar Diseases
Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.
Cerebellar Diseases
Role of magnetic resonance imaging, cerebrospinal fluid, and electroencephalogram in diagnosis of sporadic Creutzfeldt-Jakob disease.
Cerebral Amyloid Angiopathy
Cerebrovascular damage after midlife transient hypertension in non-transgenic and Alzheimer's disease rats.
Cerebral Amyloid Angiopathy
Oxidative damage of 14-3-3 zeta and gamma isoforms in Alzheimer's disease and cerebral amyloid angiopathy.
Cerebral Hemorrhage
c-Jun N-Terminal Kinase Pathway Inhibition in Intracerebral Hemorrhage.
Cerebral Hemorrhage
Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.
Cerebral Hemorrhage
Leucine-rich repeat kinase 2 aggravates secondary brain injury induced by intracerebral hemorrhage in rats by regulating the P38 MAPK/Drosha pathway.
Cerebral Hemorrhage
MST4 Kinase Inhibitor Hesperadin Attenuates Autophagy and Behavioral Disorder via the MST4/AKT Pathway in Intracerebral Hemorrhage Mice.
Cerebral Hemorrhage
Platelet-Derived Growth Factor Receptor-? Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice.
Cerebral Hemorrhage
RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats.
Cerebral Hemorrhage
RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice.
Cerebral Infarction
Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats.
Cerebral Infarction
Baicalin protects neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1
Cerebral Infarction
Butylphthalide inhibits nerve cell apoptosis in cerebral infarction rats via the JNK/p38 MAPK signaling pathway.
Cerebral Infarction
Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3?.
Cerebral Infarction
Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis.
Cerebral Infarction
Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation.
Cerebral Infarction
LncRNA SNHG1 inhibits neuronal apoptosis in cerebral infarction rats through PI3K/Akt signaling pathway.
Cerebral Infarction
MiR-29 inhibits neuronal apoptosis in rats with cerebral infarction through regulating Akt signaling pathway.
Cerebral Infarction
Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats.
Cerebral Infarction
Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.
Cerebral Infarction
Sevoflurane postconditioning attenuates cerebral ischemia-reperfusion injury via protein kinase B/nuclear factor-erythroid 2-related factor 2 pathway activation.
Cerebral Infarction
Sevoflurane postconditioning involves an up-regulation of HIF-1? and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia.
Cerebral Infarction
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Cerebral Infarction
[Effect of Schisandra chinensis lignans on neuronal apoptosis and p-AKT expression of rats in cerebral ischemia injury model].
Cerebrovascular Disorders
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Cerebrovascular Disorders
CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.
Cervical Intraepithelial Neoplasia
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
cgmp-dependent protein kinase deficiency
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
Chagas Disease
Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection.
Charcot-Marie-Tooth Disease
A stress-free strategy to correct point mutations in patient iPS cells.
Charcot-Marie-Tooth Disease
Combination of myotonic dystrophy and hereditary motor and sensory neuropathy.
Chemical and Drug Induced Liver Injury
Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway.
Cherubism
Point mutations of 3BP2 identified in human-inherited disease cherubism result in the loss of function.
Chickenpox
Antiherpetic potential of 6-bromoindirubin-3'-acetoxime (BIO-acetoxime) in human oral epithelial cells.
Chickenpox
Histone Deacetylase 1 and 2 are Phosphorylated at Novel Sites During Varicella Zoster Virus Infection.
Chickenpox
Phosphorylation of the Nuclear Form of Varicella Zoster Virus Immediate-Early Protein 63 by Casein Kinase II at Serine 186.
Cholangiocarcinoma
Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism.
Cholangiocarcinoma
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Cholangiocarcinoma
CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism.
Cholangiocarcinoma
Depletion of STYK1 inhibits intrahepatic cholangiocarcinoma development both in vitro and in vivo.
Cholangiocarcinoma
Immunohistochemical analysis of the mTOR pathway in intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
Cholangiocarcinoma
JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.
Cholangiocarcinoma
LRRK2 Is Associated with Recurrence-Free Survival in Intrahepatic Cholangiocarcinoma and Downregulation of LRRK2 Suppresses Tumor Progress In Vitro.
Cholangiocarcinoma
Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.
Cholangiocarcinoma
NOTCH1 regulates the viability of cholangiocarcinoma cells via 14-3-3 theta.
Cholangiocarcinoma
Overexpressions of CK2? and XIAP are Associated with Poor Prognosis of Patients with Cholangiocarcinoma.
Cholangiocarcinoma
Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells.
Cholangiocarcinoma
Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma.
Cholangiocarcinoma
PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma.
Cholangiocarcinoma
Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression.
Cholangiocarcinoma
Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker.
Cholangiocarcinoma
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities.
Cholangiocarcinoma
Suppression of 14-3-3? in cholangiocarcinoma cells inhibits proliferation through attenuated Akt activity, enhancing chemosensitivity to gemcitabine.
Cholangiocarcinoma
Suppression of PRKAR1A Expression Enhances Anti- proliferative and Apoptotic Effects of Protein Kinase Inhibitors and Chemotherapeutic Drugs on Cholangiocarcinoma Cells.
Cholangiocarcinoma
The antiproliferative effects of ataxia-telangiectasia mutated and ATM- and Rad3-related inhibitions and their enhancements with the cytotoxicity of DNA damaging agents in cholangiocarcinoma cells.
Cholangiocarcinoma
The clinicopathological and prognostic impact of 14-3-3 protein isoforms expression in human cholangiocarcinoma by immunohistochemistry.
Cholangiocarcinoma
The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
Cholangiocarcinoma
The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas.
Cholangiocarcinoma
The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells.
Cholangiocarcinoma
The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.
Cholangiocarcinoma
Up-regulation of 14-3-3? expression in intrahepatic cholangiocarcinoma and its clinical implications.
Cholangiocarcinoma
Upregulation of 14-3-3 eta in chronic liver fluke infection is a potential diagnostic marker of cholangiocarcinoma.
Cholangiocarcinoma
Yin Yang 1-induced LINC00667 up-regulates pyruvate dehydrogenase kinase 1 to promote proliferation, migration and invasion of cholangiocarcinoma cells by sponging miR-200c-3p.
Cholangiocarcinoma
[Activated serine/threonine kinase AKT enhances the radioresistancy in human cholangiocarcinoma]
Cholangitis, Sclerosing
Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
Cholecystitis
Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
Cholera
Action of cAMP on expression and release of adhesion molecules in human endothelial cells.
Cholera
Activation of G-protein-coupled receptor 30 increases T-type calcium currents in trigeminal ganglion neurons via the cholera toxin-sensitive protein kinase A pathway.
Cholera
Acute and chronic regulation of Na+/K+-ATPase transport activity in the RN22 Schwann cell line in response to stimulation of cyclic AMP production.
Cholera
Antiproliferative effect of brief exposure to cholera toxin in vascular smooth muscle cells: role of cAMP and protein kinase A.
Cholera
ATP-induced inhibition of Na+, K+, Cl- cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways.
Cholera
Basic fibroblast growth factor stimulates repair of wounded hepatocyte monolayer: modulatory role of protein kinase A and extracellular matrix.
Cholera
Calcium-independent and cAMP-dependent modulation of soluble guanylyl cyclase activity by G protein-coupled receptors in pituitary cells.
Cholera
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Cholera
Characterization of parathyroid hormone/parathyroid hormone-related protein receptor and signaling in hypercalcemic Walker 256 tumor cells.
Cholera
Cholera toxin stimulates type II pneumocyte proliferation by a cyclic AMP-independent mechanism.
Cholera
Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c?Raf/MEK/ERK signaling pathway.
Cholera
Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A.
Cholera
Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol.
Cholera
Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals.
Cholera
Glycogen synthase kinases-3beta controls differentiation of malignant glioma cells.
Cholera
Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene.
Cholera
Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line.
Cholera
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Cholera
Inhibition of oxytocin-stimulated phosphoinositide turnover in rat myometrium by pertussis and cholera toxins may involve protein kinase A activation.
Cholera
Inhibition of the H+/peptide cotransporter in the human intestinal cell line Caco-2 by cyclic AMP.
Cholera
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Cholera
Mechanisms mediating pituitary adenylate cyclase-activating polypeptide depolarization of rat sympathetic neurons.
Cholera
Molecular modulation of inward and outward apical transporters of L-dopa in LLC-PK(1) cells.
Cholera
Molecular Regulation of Human Placental Growth Factor (PlGF) Gene Expression in Placental Villi and Trophoblast Cells is Mediated via the Protein Kinase A Pathway.
Cholera
Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.
Cholera
Physiological evidence of integrin-antibody reactive proteins influencing the innate cellular immune responses of larval Galleria mellonella hemocytes.
Cholera
Pituitary adenylate cyclase-activating polypeptide and cyclic adenosine 3',5'-monophosphate stimulate the promoter activity of the rat gonadotropin-releasing hormone receptor gene via a bipartite response element in gonadotrope-derived cells.
Cholera
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.
Cholera
Regulation of Bcl-2 protein expression in human neuroblastoma SH-SY5Y cells: positive and negative effects of protein kinases C and A, respectively.
Cholera
Regulation of extracellular calcium sensing in rat osteoclasts by femtomolar calcitonin concentrations.
Cholera
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells.
Cholera
Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activity.
Cholera
Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells.
Cholera
Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism.
Cholera
Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway.
Cholera
Stimulation or endothelin-1 secretion by human breast cancer cells through protein kinase A activation: a possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2.
Cholera
Suppression of voltage-dependent K+ currents in retinal bipolar cells by ascorbate.
Cholera
The cross-regulation of Gi-protein by cholera toxin involves a phosphorylation by protein kinase A.
Cholera
TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
Cholestasis
Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver.
Cholesteatoma
Activation of the EGFR/Akt/NF-?B/cyclinD1 survival signaling pathway in human cholesteatoma epithelium.
Cholesteatoma
Autophagy Is Deficient and May be Negatively Regulated by SERPINB3 in Middle Ear Cholesteatoma.
Cholesteatoma
The role of EGFR/PI3K/Akt/cyclinD1 signaling pathway in acquired middle ear cholesteatoma.
Cholesteatoma
[Expression and significance of PTEN, P-ERK and P-AKT in the middle ear cholesteatoma].
Cholesteatoma, Middle Ear
[Expression and significance of PTEN, P-ERK and P-AKT in the middle ear cholesteatoma].
Chondroma
IDH1 immunohistochemistry reactivity and mosaic IDH1 or IDH2 somatic mutations in pediatric sporadic enchondroma and enchondromatosis.
Chondrosarcoma
CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-?B signaling pathway.
Chondrosarcoma
p38 kinase and c-Jun N-terminal kinase oppositely regulates tumor necrosis factor alpha-induced vascular cell adhesion molecule-1 expression and cell adhesion in chondrosarcoma cells.
Chondrosarcoma
Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells.
Chordoma
Inhibition Of Glycogen Synthase Kinase 3 Beta Suppresses The Growth And Survival Of Skull Base Chordoma Cells By Downregulating Brachyury Expression.
Chordoma
Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence.
Chordoma
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
Choriocarcinoma
Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line.
Choriocarcinoma
Cyclic AMP and phorbol esters interact synergistically to regulate expression of the chorionic gonadotropin genes.
Choriocarcinoma
Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells.
Choriocarcinoma
Human colony stimulating factor-1 receptor activates the C-raf-1 proto-oncogene kinase.
Choriocarcinoma
Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line.
Choriocarcinoma
Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma.
Choriocarcinoma
Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells.
Choriocarcinoma
Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells.
Chronic Periodontitis
ASC-dependent RIP2 Kinase Regulates Reduced PGE2 Production in Chronic Periodontitis.
Ciliary Motility Disorders
Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect.
Ciliopathies
Accumulation of the Raf-1 Kinase Inhibitory Protein (Rkip) Is Associated with Cep290-mediated Photoreceptor Degeneration in Ciliopathies.
Ciliopathies
Loss of Raf-1 kinase inhibitory protein delays early-onset severe retinal ciliopathy in Cep290rd16 mouse.
Ciliopathies
STK11 is required for the normal program of ciliated cell differentiation in airways.
Classical Lissencephalies and Subcortical Band Heterotopias
14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.
Classical Lissencephalies and Subcortical Band Heterotopias
14-3-3? gene variants in a Japanese patient with left ventricular noncompaction and hypoplasia of the corpus callosum.
Cleft Palate
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.
Cleft Palate
Relevance of the palatal protein kinase A pathway to the pathogenesis of cleft palate by secalonic acid D in mice.
Clonorchiasis
Identification and molecular characterization of a novel signaling molecule 14-3-3 epsilon in Clonorchis sinensis excretory/secretory products.
Clonorchiasis
The identification of antigenic proteins: 14-3-3 protein and propionyl-CoA carboxylase in Clonorchis sinensis.
Cockayne Syndrome
Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.
Coffin-Lowry Syndrome
An Xp22.12 microduplication including RPS6KA3 identified in a family with variably affected intellectual and behavioral disabilities.
Coffin-Lowry Syndrome
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore.
Coffin-Lowry Syndrome
Intronic L1 insertion and F268S, novel mutations in RPS6KA3 (RSK2) causing Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
Coffin-Lowry Syndrome
Prenatal diagnosis in Coffin-Lowry syndrome demonstrates germinal mosaicism confirmed by mutation analysis.
Coffin-Lowry Syndrome
RSK2 enzymatic assay as a second level diagnostic tool in Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid.
Coffin-Lowry Syndrome
Transcriptome profile reveals AMPA receptor dysfunction in the hippocampus of the Rsk2-knockout mice, an animal model of Coffin-Lowry syndrome.
Coffin-Lowry Syndrome
Unreported RSK2 missense mutation in two male sibs with an unusually mild form of Coffin-Lowry syndrome.
Coinfection
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Coinfection
Coinfection of insect cells with recombinant baculovirus expressing pp60v-src results in the activation of a serine-specific protein kinase pp90rsk.
Coinfection
Differential gel electrophoresis (DIGE) to quantitatively monitor early symbiosis- and pathogenesis-induced changes of the Medicago truncatula root proteome.
Coinfection
Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases.
Coinfection
Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.
Coinfection
The role of annexin A1 in Candida albicans and Candida auris infections in murine neutrophils.
Colitis
Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide.
Colitis
An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.
Colitis
CARD3 Deficiency Protects Against Colitis Through Reduced Epithelial Cell Apoptosis.
Colitis
CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.
Colitis
Cilostazol protects against acetic acid-induced colitis in rats: Possible role for cAMP/SIRT1 pathway.
Colitis
COX-1/PGE2/EP4 alleviates mucosal injury by upregulating ?-arr1-mediated Akt signaling in colitis.
Colitis
Effects of curcumin on apoptosis and oxidoinflammatory regulation in a rat model of acetic acid-induced colitis: the roles of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.
Colitis
ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction.
Colitis
EXPRESS: Phospholipase C gamma mediates endogenous brain-derived neurotrophic factor - regulated calcitonin gene-related peptide expression in colitis - induced visceral pain.
Colitis
Expression of A-kinase anchor protein 13 and Rho-associated coiled-coil containing protein kinase in restituted and regenerated mucosal epithelial cells following mucosal injury and colorectal cancer cells in mouse models.
Colitis
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-?/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study.
Colitis
Lactobacillus casei protects dextran sodium sulfate- or rapamycin-induced colonic inflammation in the mouse.
Colitis
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Colitis
LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease.
Colitis
Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.
Colitis
Protective effects of panax notoginseng saponin on dextran sulfate sodium-induced colitis in rats through phosphoinositide-3-kinase protein kinase B signaling pathway inhibition.
Colitis
Protein kinase 2 (CK2) controls CD4+ T cell effector function in the pathogenesis of colitis.
Colitis
Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.
Colitis
Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.
Colitis
Suppression of epithelial restitution using an inhibitor against Rho-associated coiled-coil containing protein kinase aggravates colitis through reduced epithelial expression of A-kinase anchor protein 13.
Colitis
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Colitis, Ulcerative
An Inhibitor of Casein Kinase 1?/? (PF670462) Prevents the Deterioration of Dextran Sodium Sulfate-induced Ulcerative Colitis Caused by UVB Eye Irradiation.
Colitis, Ulcerative
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding.
Colitis, Ulcerative
Fusobacterium nucleatum facilitates ulcerative colitis through activating IL-17F signaling to NF-?B via the upregulation of CARD3 expression.
Colitis, Ulcerative
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colitis, Ulcerative
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Colitis, Ulcerative
Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis.
Colitis, Ulcerative
TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis.
Colonic Neoplasms
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
Colonic Neoplasms
5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Colonic Neoplasms
?-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths.
Colonic Neoplasms
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.
Colonic Neoplasms
A novel cancer testis antigen target A-kinase anchor protein (AKAP4) for the early diagnosis and immunotherapy of colon cancer.
Colonic Neoplasms
A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Colonic Neoplasms
A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells.
Colonic Neoplasms
A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.
Colonic Neoplasms
A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
Colonic Neoplasms
Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells .
Colonic Neoplasms
Activity of glycogen synthase kinase-3beta is down-regulated during transient differentiation of human colon cancer HT-29 cells.
Colonic Neoplasms
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells.
Colonic Neoplasms
Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3.
Colonic Neoplasms
Association between the expression levels of TAZ, AXL and CTGF and clinicopathological parameters in patients with colon cancer.
Colonic Neoplasms
Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer.
Colonic Neoplasms
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.
Colonic Neoplasms
Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer.
Colonic Neoplasms
Binding between ROCK1 and DCTN2 triggers diabetes?associated centrosome amplification in colon cancer cells.
Colonic Neoplasms
Ca(2+)/calmodulin-dependent protein kinase II promotes cell cycle progression by directly activating MEK1 and subsequently modulating p27 phosphorylation.
Colonic Neoplasms
Calotropin: A Cardenolide from Calotropis gigantea that Inhibits Wnt Signaling by Increasing Casein Kinase 1? in Colon Cancer Cells.
Colonic Neoplasms
CaMKII Mediates TGF?1-Induced Fibroblasts Activation and Its Cross Talk with Colon Cancer Cells.
Colonic Neoplasms
Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls.
Colonic Neoplasms
Cancer selective metallocenedicarboxylates of the fungal cytotoxin illudin M.
Colonic Neoplasms
Casein kinase 2 regulates the mRNA-destabilizing activity of tristetraprolin.
Colonic Neoplasms
Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex.
Colonic Neoplasms
Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line.
Colonic Neoplasms
Chemical characterization and biological activity data for a novel indirubin derivative, LDD-1819.
Colonic Neoplasms
Chemotherapy Regimen GOLF Induces Apoptosis in Colon Cancer Cells through Multi-Chaperone Complex Inactivation and Increased Raf-1 Ubiquitin-Dependent Degradation.
Colonic Neoplasms
Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of beta-catenin signaling.
Colonic Neoplasms
Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro.
Colonic Neoplasms
Colchicine induces apoptosis in HT?29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways.
Colonic Neoplasms
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability.
Colonic Neoplasms
Colon cancer-associated transcript-1 enhances glucose metabolism and colon cancer cell activity in a high-glucose environment in vitro and in vivo.
Colonic Neoplasms
Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells.
Colonic Neoplasms
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Colonic Neoplasms
Comparative mutational analysis of distal colon cancer with rectal cancer.
Colonic Neoplasms
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.
Colonic Neoplasms
Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.
Colonic Neoplasms
Development and biological evaluation of a novel aurora A kinase inhibitor.
Colonic Neoplasms
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
Colonic Neoplasms
Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling.
Colonic Neoplasms
Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells.
Colonic Neoplasms
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
Colonic Neoplasms
Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.
Colonic Neoplasms
Effects of epidermal growth factor and mitogenic pathway inhibitors on rat colon cancer proliferation in vitro.
Colonic Neoplasms
Erlotinib inhibits colon cancer metastasis through inactivation of TrkB-dependent ERK signaling pathway.
Colonic Neoplasms
Eupafolin Suppresses Esophagus Cancer Growth by Targeting T-LAK Cell-Originated Protein Kinase.
Colonic Neoplasms
Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues.
Colonic Neoplasms
Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane.
Colonic Neoplasms
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Colonic Neoplasms
Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity.
Colonic Neoplasms
Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway.
Colonic Neoplasms
Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.
Colonic Neoplasms
Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.
Colonic Neoplasms
Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content.
Colonic Neoplasms
Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway.
Colonic Neoplasms
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.
Colonic Neoplasms
HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon cancer cells.
Colonic Neoplasms
Hydroxychavicol, a polyphenol from Piper betle leaf extract, induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells.
Colonic Neoplasms
Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1.
Colonic Neoplasms
IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas.
Colonic Neoplasms
Immuno-Affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance.
Colonic Neoplasms
In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
Colonic Neoplasms
Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity.
Colonic Neoplasms
Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents.
Colonic Neoplasms
Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells.
Colonic Neoplasms
Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues.
Colonic Neoplasms
Intratumoral heterogeneity of CSNK1G3 mutations, a casein kinase 1, in colon cancers.
Colonic Neoplasms
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Colonic Neoplasms
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma.
Colonic Neoplasms
Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells.
Colonic Neoplasms
Kinase signaling pathways as targets for intervention in pancreatic cancer.
Colonic Neoplasms
Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway.
Colonic Neoplasms
Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling.
Colonic Neoplasms
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Colonic Neoplasms
Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer.
Colonic Neoplasms
Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation.
Colonic Neoplasms
Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648.
Colonic Neoplasms
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer.
Colonic Neoplasms
MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.
Colonic Neoplasms
MicroRNA-27a Promotes the Proliferation and Invasiveness of Colon Cancer Cells by Targeting SFRP1 through the Wnt/?-Catenin Signaling Pathway.
Colonic Neoplasms
MiR-566 mediates cell migration and invasion in colon cancer cells by direct targeting of PSKH1.
Colonic Neoplasms
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.
Colonic Neoplasms
MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth.
Colonic Neoplasms
Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example.
Colonic Neoplasms
Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection.
Colonic Neoplasms
Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.
Colonic Neoplasms
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA.
Colonic Neoplasms
Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.
Colonic Neoplasms
p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells.
Colonic Neoplasms
Pharmacological Inhibition of Casein Kinase 2 Enhances the Effectiveness of PI3K Inhibition in Colon Cancer Cells.
Colonic Neoplasms
Phenotypic Profiling of Raf Inhibitors and Mitochondrial Toxicity in 3D Tissue Using Biodynamic Imaging.
Colonic Neoplasms
Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.
Colonic Neoplasms
Polymerase synthesis and potential interference of a small-interfering RNA targeting hPim-2.
Colonic Neoplasms
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Colonic Neoplasms
Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.
Colonic Neoplasms
Protein kinase D1 attenuates tumorigenesis in colon cancer by modulating ?-catenin/T cell factor activity.
Colonic Neoplasms
Proteomic analysis of differentially expressed proteins in peripheral cholangiocarcinoma.
Colonic Neoplasms
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.
Colonic Neoplasms
PRP4 Kinase Domain Loss Nullifies Drug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells.
Colonic Neoplasms
Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.
Colonic Neoplasms
RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Colonic Neoplasms
Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.
Colonic Neoplasms
Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial? mesenchymal transition via the AKT/GSK?3?/Snail signaling pathway.
Colonic Neoplasms
Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.
Colonic Neoplasms
RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo.
Colonic Neoplasms
RNA sequencing identified novel target genes for Adansonia digitata in breast and colon cancer cells.
Colonic Neoplasms
Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-?B-dependent GLUT3 expression.
Colonic Neoplasms
Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Colonic Neoplasms
Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells.
Colonic Neoplasms
Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin.
Colonic Neoplasms
Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone.
Colonic Neoplasms
Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy.
Colonic Neoplasms
The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines.
Colonic Neoplasms
The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta.
Colonic Neoplasms
The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling.
Colonic Neoplasms
Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function.
Colonic Neoplasms
Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon.
Colonic Neoplasms
Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation.
Colonic Neoplasms
Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.
Colonic Neoplasms
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor.
Colonic Neoplasms
Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3beta-dependent Manner.
Colonic Neoplasms
Upregulation of miR-542-3p inhibits the growth and invasion of human colon cancer cells through PI3K/AKT/survivin signaling.
Colonic Neoplasms
Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells.
Colonic Neoplasms
Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.
Colonic Neoplasms
[Study on the Effect of Overexpression of miR-18a on Cellular Proliferation and Migration by Targeting ATM in Human Colorectal Cancer Cells].
Colonic Neoplasms
[The anti-tumor activity and molecular mechanisms of an Aurora kinase inhibitor ZLJ213 in suppressing colon cancer growth].
Colorectal Neoplasms
15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
Colorectal Neoplasms
3'-hydroxy-4'-methoxy-?-methyl-?-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction.
Colorectal Neoplasms
A Meta-Regression Method for Studying Etiological Heterogeneity Across Disease Subtypes Classified by Multiple Biomarkers.
Colorectal Neoplasms
A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer.
Colorectal Neoplasms
A novel mechanism of keratin cytoskeleton organization through casein kinase I? and FAM83H in colorectal cancer.
Colorectal Neoplasms
A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
Colorectal Neoplasms
A-Kinase Anchoring Proteins 10 Expression in Relation to 2073A/G Polymorphism and Tumor Progression in Patients with Colorectal Cancer.
Colorectal Neoplasms
Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.
Colorectal Neoplasms
Activation of AKT signaling promotes epithelial-mesenchymal transition and tumor growth in colorectal cancer cells.
Colorectal Neoplasms
Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells.
Colorectal Neoplasms
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.
Colorectal Neoplasms
Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin/+ mouse.
Colorectal Neoplasms
Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.
Colorectal Neoplasms
Apical membrane localization of glycogen synthase kinase 3beta protein in normal colon epithelium and aberrant distribution in colorectal cancer.
Colorectal Neoplasms
Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-?e8 isoform.
Colorectal Neoplasms
Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer.
Colorectal Neoplasms
ATMIN Suppresses Metastasis by Altering the WNT-Signaling Pathway via PARP1 in MSI-High Colorectal Cancer.
Colorectal Neoplasms
Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers.
Colorectal Neoplasms
Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53.
Colorectal Neoplasms
Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.
Colorectal Neoplasms
AZ32 Reverses ABCG2-Mediated Multidrug Resistance in Colorectal Cancer.
Colorectal Neoplasms
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
Colorectal Neoplasms
BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Colorectal Neoplasms
BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma.
Colorectal Neoplasms
Case-control, kin-cohort and meta-analyses provide no support for STK15 F31I as a low penetrance colorectal cancer allele.
Colorectal Neoplasms
Casein Kinase 2? Enhances 5-Fluorouracil Resistance in Colorectal Cancer Cells by Inhibiting Endoplasmic Reticulum Stress.
Colorectal Neoplasms
Casein Kinase-1-Alpha Inhibitor (D4476) Sensitizes Microsatellite Instable Colorectal Cancer Cells to 5-Fluorouracil via Authophagy Flux Inhibition.
Colorectal Neoplasms
Cell surface integrin ?5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3.
Colorectal Neoplasms
Characterization of casein kinase II in human colonic carcinomas after heterotransplantation into nude mice.
Colorectal Neoplasms
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.
Colorectal Neoplasms
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Colorectal Neoplasms
Clinical significance of RKIP mRNA expression in non-small cell lung cancer.
Colorectal Neoplasms
Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells.
Colorectal Neoplasms
Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis.
Colorectal Neoplasms
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.
Colorectal Neoplasms
Combined Short-Term Glucose Starvation and Chemotherapy in 3D Colorectal Cancer Cell Culture Decreases 14-3-3 Family Protein Expression and Phenotypic Response to Therapy.
Colorectal Neoplasms
Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer.
Colorectal Neoplasms
Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.
Colorectal Neoplasms
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Colorectal Neoplasms
Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression.
Colorectal Neoplasms
CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer.
Colorectal Neoplasms
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Colorectal Neoplasms
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.
Colorectal Neoplasms
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Colorectal Neoplasms
Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer.
Colorectal Neoplasms
Diagnostic relevance of overexpressed serine threonine tyrosine kinase/novel oncogene with kinase domain (STYK1/ NOK) mRNA in colorectal cancer.
Colorectal Neoplasms
Differences in symptom occurrence, severity, and distress ratings between patients with gastrointestinal cancers who received chemotherapy alone or chemotherapy with targeted therapy.
Colorectal Neoplasms
DNA-PKcs interference sensitizes colorectal cancer cells to a mTOR kinase inhibitor WAY-600.
Colorectal Neoplasms
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
Colorectal Neoplasms
Effect of casein kinase 1? inhibition on autophagy flux and the AKT/phospho-?-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line.
Colorectal Neoplasms
Effect of Raf kinase inhibitor protein expression on malignant biological behavior and progression of colorectal cancer.
Colorectal Neoplasms
Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.
Colorectal Neoplasms
Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.
Colorectal Neoplasms
Emodin suppresses growth and invasion of colorectal cancer cells by inhibiting VEGFR2.
Colorectal Neoplasms
Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells.
Colorectal Neoplasms
Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2.
Colorectal Neoplasms
Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer.
Colorectal Neoplasms
Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue.
Colorectal Neoplasms
Expression of A-kinase anchor protein 13 and Rho-associated coiled-coil containing protein kinase in restituted and regenerated mucosal epithelial cells following mucosal injury and colorectal cancer cells in mouse models.
Colorectal Neoplasms
Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues.
Colorectal Neoplasms
Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression.
Colorectal Neoplasms
Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases.
Colorectal Neoplasms
Expression of phosphorylated extracellular signal-regulated kinase at the invasive front of hepatic colorectal metastasis.
Colorectal Neoplasms
Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability.
Colorectal Neoplasms
Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Colorectal Neoplasms
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.
Colorectal Neoplasms
Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.
Colorectal Neoplasms
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Colorectal Neoplasms
Genetic Variations in STK11, PRKAA1, and TSC1 Associated with Prognosis for Patients with Colorectal Cancer.
Colorectal Neoplasms
Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer.
Colorectal Neoplasms
Germline Genetic Variants in the Wnt/?-Catenin Pathway as Predictors of Colorectal Cancer Risk.
Colorectal Neoplasms
Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase.
Colorectal Neoplasms
GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
Colorectal Neoplasms
High frequency of DAP-kinase gene promoter methylation in colorectal cancer specimens and its identification in serum.
Colorectal Neoplasms
HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer.
Colorectal Neoplasms
HIPK2 phosphorylates HDAC3 for NF-?B acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
Colorectal Neoplasms
HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation.
Colorectal Neoplasms
Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
Colorectal Neoplasms
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization-Based Assay.
Colorectal Neoplasms
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3?.
Colorectal Neoplasms
Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway.
Colorectal Neoplasms
IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells.
Colorectal Neoplasms
IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF-1 degradation by miR-195.
Colorectal Neoplasms
Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy.
Colorectal Neoplasms
Increased expression of beta-catenin, phosphorylated glycogen synthase kinase 3beta, cyclin D1, and c-myc in laterally spreading colorectal tumors.
Colorectal Neoplasms
Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related (ATR) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer.
Colorectal Neoplasms
Interleukin-17 promotes the development of cisplatin resistance in colorectal cancer.
Colorectal Neoplasms
Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.
Colorectal Neoplasms
KNOCKDOWN OF CASEIN KINASE 1e INHIBITS CELL PROLIFERATION AND INVASION OF COLORECTAL CANCER CELLS VIA INHIBITION OF THE Wnt/?-CATENIN SIGNALING.
Colorectal Neoplasms
KRAS and BRAF mutations in serum exosomes from patients with colorectal cancer in a Chinese population.
Colorectal Neoplasms
Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer.
Colorectal Neoplasms
Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer.
Colorectal Neoplasms
Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells.
Colorectal Neoplasms
Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation.
Colorectal Neoplasms
MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1).
Colorectal Neoplasms
MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer.
Colorectal Neoplasms
MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer.
Colorectal Neoplasms
MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase.
Colorectal Neoplasms
MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1.
Colorectal Neoplasms
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Colorectal Neoplasms
Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer.
Colorectal Neoplasms
Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma.
Colorectal Neoplasms
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
Colorectal Neoplasms
Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression.
Colorectal Neoplasms
Nondysplastic Ulcerative Colitis Has High Levels of the Homologous Recombination Repair Protein NUCKS1 and Low Levels of the DNA Damage Marker Gamma-H2AX.
Colorectal Neoplasms
Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon.
Colorectal Neoplasms
Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors.
Colorectal Neoplasms
NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3.
Colorectal Neoplasms
Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition.
Colorectal Neoplasms
Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/?-Catenin Signaling.
Colorectal Neoplasms
Optimization of the diagnosis of inherited colorectal cancer using NGS and capture of exonic and intronic sequences of panel genes.
Colorectal Neoplasms
Overexpression of integrin-linked kinase (ILK) is associated with tumor progression and an unfavorable prognosis in patients with colorectal cancer.
Colorectal Neoplasms
Overexpression of integrin-linked kinase (ILK) promotes migration and invasion of colorectal cancer cells by inducing epithelial-mesenchymal transition via NF-?B signaling.
Colorectal Neoplasms
Overexpression of nuclear protein kinase CK2 ? catalytic subunit (CK2?) as a poor prognosticator in human colorectal cancer.
Colorectal Neoplasms
p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells.
Colorectal Neoplasms
PB-10, a thiazolo[4,5-d] pyrimidine derivative, targets p21-activated kinase 4 in human colorectal cancer cells.
Colorectal Neoplasms
Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells.
Colorectal Neoplasms
Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.
Colorectal Neoplasms
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells.
Colorectal Neoplasms
Phosphorylation of p70 Ribosomal Protein S6 Kinase ?-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer.
Colorectal Neoplasms
Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer.
Colorectal Neoplasms
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Colorectal Neoplasms
PI3K/Akt and GSK-3beta prevents in a differential fashion the malignant phenotype of colorectal cancer cells.
Colorectal Neoplasms
PIK3CA mutation is predictive of poor survival in patients with colorectal cancer.
Colorectal Neoplasms
Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors.
Colorectal Neoplasms
Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma.
Colorectal Neoplasms
Possible Gender-Related Modulation by the ROCK1 Gene in Colorectal Cancer Susceptibility.
Colorectal Neoplasms
Preliminary Study on the Identification of BRAFV600E Mutation in Colorectal Cancer by Near-Infrared Spectroscopy.
Colorectal Neoplasms
Prevalence and prognostic relevance of BrafV600E mutation in colorectal carcinomas from Kashmir (North India) valley.
Colorectal Neoplasms
Probiotic Lactobacillus salivarius Ren prevent dimethylhydrazine-induced colorectal cancer through protein kinase B inhibition.
Colorectal Neoplasms
Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa.
Colorectal Neoplasms
Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer.
Colorectal Neoplasms
Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer.
Colorectal Neoplasms
PRP4 Kinase Domain Loss Nullifies Drug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells.
Colorectal Neoplasms
Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4? in Colorectal Cancer Cells.
Colorectal Neoplasms
Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways.
Colorectal Neoplasms
Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients.
Colorectal Neoplasms
Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients.
Colorectal Neoplasms
Raf-1 kinase, epidermal growth factor receptors, and mutant Ras proteins in colonic carcinomas.
Colorectal Neoplasms
Receptor-Interacting Serine/Threonine-Protein Kinase-2 as a Potential Prognostic Factor in Colorectal Cancer.
Colorectal Neoplasms
Reduced Raf-1 kinase inhibitor protein expression predicts less favorable outcomes in patients with hepatic colorectal metastasis.
Colorectal Neoplasms
Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated beta-catenin.
Colorectal Neoplasms
Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3? (GSK-3?) and microtubule-associated protein 1B.
Colorectal Neoplasms
Role of serine/threonine kinase 33 methylation in colorectal cancer and its clinical significance.
Colorectal Neoplasms
Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer.
Colorectal Neoplasms
Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Colorectal Neoplasms
Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer.
Colorectal Neoplasms
Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/?-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.
Colorectal Neoplasms
STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1?/VEGF signaling pathway.
Colorectal Neoplasms
Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers.
Colorectal Neoplasms
Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer.
Colorectal Neoplasms
Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library.
Colorectal Neoplasms
Targeting BRAF in metastatic colorectal cancer: Maximizing molecular approaches.
Colorectal Neoplasms
Targeting cytosolic phospholipase A2 ? in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation.
Colorectal Neoplasms
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
Colorectal Neoplasms
TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.
Colorectal Neoplasms
The clinical implication of 14-3-3 sigma expression in primary gastrointestinal malignancy.
Colorectal Neoplasms
The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells.
Colorectal Neoplasms
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer.
Colorectal Neoplasms
The Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer.
Colorectal Neoplasms
The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Colorectal Neoplasms
The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer.
Colorectal Neoplasms
The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas.
Colorectal Neoplasms
The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines.
Colorectal Neoplasms
The roles of microbial products in the development of colorectal cancer: a review.
Colorectal Neoplasms
TRIM27 functions as an oncogene by activating epithelial-mesenchymal transition and p-AKT in colorectal cancer.
Colorectal Neoplasms
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Colorectal Neoplasms
Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.
Colorectal Neoplasms
[Clinicopathological significance of expression and amplification of P21-activated kinase 1 gene in colorectal carcinoma]
Colorectal Neoplasms
[Clinicopathological significance of expressions of DNA dependent protein kinase catalytic subunit and P16 in colorectal carcinoma]
Colorectal Neoplasms
[Correlation of casein kinase 2? overexpression to the metastatic ability of colorectal cancer cells in vitro].
Colorectal Neoplasms
[Effect of p21-activated kinase-1 on the invasiveness of colorectal carcinoma cells in vitro]
Colorectal Neoplasms
[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]
Colorectal Neoplasms, Hereditary Nonpolyposis
Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.
Colorectal Neoplasms, Hereditary Nonpolyposis
Molecular dimensions of gastrointestinal tumors: some thoughts for digestion.
Colorectal Neoplasms, Hereditary Nonpolyposis
Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients.
Colorectal Neoplasms, Hereditary Nonpolyposis
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Colorectal Neoplasms, Hereditary Nonpolyposis
Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA.
Colorectal Neoplasms, Hereditary Nonpolyposis
Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes.
Colorectal Neoplasms, Hereditary Nonpolyposis
The influence of STK11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review.
Colorectal Neoplasms, Hereditary Nonpolyposis
Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care.
Coma
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma.
Coma
Persistent translocation and inhibition of Ca2+/calmodulin-dependent protein kinase II in the crude synaptosomal fraction of the vulnerable hippocampus following hypoglycemia.
Common Variable Immunodeficiency
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency.
Communicable Diseases
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.
Communicable Diseases
Glycogen synthase 3 (GSK-3) regulation of PD-1 expression and and its therapeutic implications.
Communicable Diseases
LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.
Communicable Diseases
Regulatory Role of GSK-3 ? on NF- ? B, Nitric Oxide, and TNF- ? in Group A Streptococcal Infection.
Communicable Diseases
Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice.
Communicable Diseases
Transcriptomic and Network Analysis Highlight the Association of Diabetes at Different Stages of Alzheimer's Disease.
Confusion
Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies.
Congenital Abnormalities
miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.
Congenital Disorders of Glycosylation
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Congenital Hyperinsulinism
Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Contracture
CaMKII mediates myocardial ischemia/reperfusion injury?induced contracture in isolated rat heart.
Contracture
Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.
Corneal Injuries
Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization.
Corneal Injuries
The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea.
Coronary Artery Disease
Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men.
Coronary Artery Disease
Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China.
Coronary Artery Disease
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Coronary Artery Disease
Delayed re-endothelialization with rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3beta inhibitor.
Coronary Artery Disease
Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease.
Coronary Artery Disease
Optimisation of methods for quantifying plasma mRNA levels from genes responsible for coronary artery plaque development and destabilization.
Coronary Disease
Klotho overexpression suppresses apoptosis by regulating the Hsp70/Akt/Bad pathway in H9c2(2-1) cells.
Coronary Occlusion
Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion.
Coronary Stenosis
Functional polymorphism rs189037 in the promoter region of ATM gene is associated with angiographically characterized coronary stenosis.
Coronavirus Infections
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.
Corticobasal Degeneration
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Corticobasal Degeneration
Corticobasal syndrome and primary progressive aphasia as manifestations of lrrk2 gene mutations.
Corticobasal Degeneration
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
Corticobasal Degeneration
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Corticobasal Degeneration
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.
COVID-19
Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection.
COVID-19
Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis.
COVID-19
Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins.
COVID-19
Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Craniocerebral Trauma
Age at Onset of Parkinson's Disease Among Ashkenazi Jewish Patients: Contribution of Environmental Factors, LRRK2 p.G2019S and GBA p.N370S Mutations.
Creutzfeldt-Jakob Syndrome
14-3-3 cerebrospinal fluid protein and Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
14-3-3 CSF levels in sporadic Creutzfeldt-Jakob disease differ across molecular subtypes.
Creutzfeldt-Jakob Syndrome
14-3-3 in the cerebrospinal fluid of patients with variant and sporadic Creutzfeldt-Jakob disease measured using capture assay able to detect low levels of 14-3-3 protein.
Creutzfeldt-Jakob Syndrome
14-3-3 protein cerebrospinal fluid detection in human growth hormone-treated Creutzfeldt-Jakob disease patients.
Creutzfeldt-Jakob Syndrome
14-3-3 protein in the CSF of patients with rapidly progressive dementia.
Creutzfeldt-Jakob Syndrome
14-3-3 Protein isoforms and atypical patterns of the 14-3-3 assay in the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
14-3-3 protein levels and isoform patterns in the cerebrospinal fluid of Creutzfeldt-Jakob disease patients in the progressive and terminal stages.
Creutzfeldt-Jakob Syndrome
14-3-3 protein, neuron-specific enolase, and S-100 protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
14-3-3 protein, total tau and phosphorylated tau in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease and neurodegenerative disease in Japan.
Creutzfeldt-Jakob Syndrome
14-3-3 Proteins, particularly of the epsilon isoform, are detectable in cerebrospinal fluids of cerebellar diseases in children.
Creutzfeldt-Jakob Syndrome
14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.
Creutzfeldt-Jakob Syndrome
14-3-3 {gamma}-isoform detection distinguishes sporadic Creutzfeldt-Jakob disease from other dementias.
Creutzfeldt-Jakob Syndrome
A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
A novel binding assay for detection of 14-3-3 protein in cerebrospinal fluid from Creutzfeldt-Jakob patients.
Creutzfeldt-Jakob Syndrome
A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD).
Creutzfeldt-Jakob Syndrome
A systematic review comparing the diagnostic value of 14-3-3 protein in the cerebrospinal fluid, RT-QuIC and RT-QuIC on nasal brushing in sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Accuracy of diagnosis criteria in patients with suspected diagnosis of sporadic Creutzfeldt-Jakob disease and detection of 14-3-3 protein, France, 1992 to 2009.
Creutzfeldt-Jakob Syndrome
Advances in diagnosing Creutzfeldt-Jakob disease with MRI and CSF 14-3-3 protein analysis.
Creutzfeldt-Jakob Syndrome
Alternative application of Tau protein in Creutzfeldt-Jakob disease diagnosis: Improvement for weakly positive 14-3-3 protein in the laboratory.
Creutzfeldt-Jakob Syndrome
An enzyme-linked immunosorbent assay to quantify 14-3-3 proteins in the cerebrospinal fluid of suspected Creutzfeldt-Jakob disease patients.
Creutzfeldt-Jakob Syndrome
Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Applicability of long-term electroencephalography in pre-mortem diagnosis of Creutzfeldt-Jakob disease: A case report.
Creutzfeldt-Jakob Syndrome
Autopsy-proven Creutzfeldt-Jakob disease in a patient with a negative 14-3-3 assay and nonspecific EEG and MRI.
Creutzfeldt-Jakob Syndrome
Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid 14-3-3 protein: variability of sporadic Creutzfeldt-Jakob disease, laboratory standards, and quantitation.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid biomarkers in clinically isolated syndromes and multiple sclerosis.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies.
Creutzfeldt-Jakob Syndrome
Cerebrospinal Fluid Biomarkers in the Diagnosis of Creutzfeldt-Jakob Disease in Slovak Patients: over 10-Year Period Review.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid brain-derived proteins in the diagnosis of Alzheimer's disease and Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Cerebrospinal Fluid Levels of 14-3-3 Gamma: What Does It Tell Us About Sporadic Creutzfeldt-Jakob Disease?
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid non-phosphorylated tau in the differential diagnosis of Creutzfeldt-Jakob disease: a comparative prospective study with 14-3-3.
Creutzfeldt-Jakob Syndrome
Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Characteristics of Korean patients with suspected Creutzfeldt-Jakob disease with 14-3-3 protein in cerebrospinal fluid: Preliminary study of the Korean Creutzfeldt-Jakob disease active surveillance program.
Creutzfeldt-Jakob Syndrome
Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis.
Creutzfeldt-Jakob Syndrome
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2.
Creutzfeldt-Jakob Syndrome
Comatose within 6 weeks, but still alive after 3 years, Creutzfeldt-Jakob disease with unusual progression.
Creutzfeldt-Jakob Syndrome
Conduction aphasia as an initial symptom in a patient with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob disease mimicking autoimmune encephalitis with CASPR2 antibodies.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob Disease Presenting as Posterior Reversible Encephalopathy Syndrome.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob disease with initial right hemiparesis masquerading as a stroke.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob disease: diagnostic utility of 14-3-3 protein immunodetection in cerebrospinal fluid.
Creutzfeldt-Jakob Syndrome
CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD.
Creutzfeldt-Jakob Syndrome
CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt-Jakob disease suspected cases with inconclusive 14-3-3 result.
Creutzfeldt-Jakob Syndrome
CSF Tau supplements 14-3-3 protein detection for sporadic Creutzfeldt-Jakob disease diagnosis while transitioning to next generation diagnostics.
Creutzfeldt-Jakob Syndrome
Desmoplakin as a Potential Candidate for Cerebrospinal Fluid Marker to Rule Out 14-3-3 False Positive Rates in Sporadic Creutzfeldt-Jakob Disease Differential Diagnosis.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 brain protein in the cerebrospinal fluid of patients with paraneoplastic neurological disorders.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3 protein in the CSF of genetic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures.
Creutzfeldt-Jakob Syndrome
Detection of CSF 14-3-3 Protein in Sporadic Creutzfeldt-Jakob Disease Patients Using a New Automated Capillary Western Assay.
Creutzfeldt-Jakob Syndrome
Determination of 14-3-3 protein levels in cerebrospinal fluid from Creutzfeldt-Jakob patients by a highly sensitive capture assay.
Creutzfeldt-Jakob Syndrome
Development of a dot blot assay with antibodies to recombinant "core" 14-3-3 protein: Evaluation of its usefulness in diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Diagnosis of Creutzfeldt-Jakob disease: effect of clinical criteria on incidence estimates. Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Discrepancies in the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Drug-induced Creutzfeldt-Jakob disease-like syndrome: early CSF analysis as useful tool for differential diagnosis.
Creutzfeldt-Jakob Syndrome
Elevated total tau/phospho-tau ratio in autopsy-proven Creutzfeldt-Jakob disease with negative 14-3-3 test results.
Creutzfeldt-Jakob Syndrome
Enhanced expression of 14-3-3 proteins in reactive astrocytes in Creutzfeldt-Jakob disease brains.
Creutzfeldt-Jakob Syndrome
ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients.
Creutzfeldt-Jakob Syndrome
Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology.
Creutzfeldt-Jakob Syndrome
Extreme loss of neurons in sporadic Creutzfeldt-Jakob disease with 14-3-3 protein in cerebrospinal fluid.
Creutzfeldt-Jakob Syndrome
Hashimoto's encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
How to improve the clinical diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain.
Creutzfeldt-Jakob Syndrome
Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD.
Creutzfeldt-Jakob Syndrome
Increased 14-3-3? and ? protein isoform expressions in parasitic eosinophilic meningitis caused by Angiostrongylus cantonensis infection in mice.
Creutzfeldt-Jakob Syndrome
Increased detection of 14-3-3 protein in cerebrospinal fluid in Sporadic Creutzfeldt-Jakob Disease during the disease course.
Creutzfeldt-Jakob Syndrome
Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway.
Creutzfeldt-Jakob Syndrome
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Lack of association between 14-3-3 beta gene (YWHAB) polymorphisms and sporadic Creutzfeldt-Jakob disease (CJD).
Creutzfeldt-Jakob Syndrome
Magnetic resonance spectroscopy and measurement of tau epitopes of autopsy proven sporadic Creutzfeldt-Jakob disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 immunoblot.
Creutzfeldt-Jakob Syndrome
Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease: a study on inter-observer agreement.
Creutzfeldt-Jakob Syndrome
Novel prion protein gene mutation presenting with subacute PSP-like syndrome.
Creutzfeldt-Jakob Syndrome
Phosphorylated 14-3-3zeta protein in the CSF of neuroleptic-treated patients.
Creutzfeldt-Jakob Syndrome
Positive 14-3-3 and tau proteins in a sporadic Creutzfeldt-Jakob disease case and a brief perspective of prion diseases in Colombia.
Creutzfeldt-Jakob Syndrome
Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases.
Creutzfeldt-Jakob Syndrome
Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea.
Creutzfeldt-Jakob Syndrome
Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.
Creutzfeldt-Jakob Syndrome
Sporadic Creutzfeldt-Jakob disease diagnostic accuracy is improved by a new CSF ELISA 14-3-3? assay.
Creutzfeldt-Jakob Syndrome
Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience.
Creutzfeldt-Jakob Syndrome
Tau and 14-3-3 of genetic and sporadic Creutzfeldt-Jakob disease patients in Israel.
Creutzfeldt-Jakob Syndrome
Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
Creutzfeldt-Jakob Syndrome
The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture.
Creutzfeldt-Jakob Syndrome
The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein.
Creutzfeldt-Jakob Syndrome
The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions.
Creutzfeldt-Jakob Syndrome
The epsilon isoform of 14-3-3 protein is a component of the prion protein amyloid deposits of Gerstmann-Sträussler-Scheinker disease.
Creutzfeldt-Jakob Syndrome
The impact of the introduction of the 14-3-3 protein assay in the surveillance of sporadic Creutzfeldt-Jakob disease in Catalonia.
Creutzfeldt-Jakob Syndrome
The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review.
Creutzfeldt-Jakob Syndrome
The role of cerebrospinal fluid proteins as early diagnostic markers for sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.
Creutzfeldt-Jakob Syndrome
Use of 14-3-3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic.
Creutzfeldt-Jakob Syndrome
Visual symptoms in the presentation of Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
[Analyses of 14-3-3 protein in the cerebrospinal fluid in Creutzfeldt-Jakob disease. Preliminary report]
Creutzfeldt-Jakob Syndrome
[Cerebrospinal fluid examination in the infectious meningitis and encephalitis]
Creutzfeldt-Jakob Syndrome
[Clinical algorithm for cerebrospinal fluid test of 14-3-3 protein in diagnosis of Creutzfeldt-Jacob disease]
Creutzfeldt-Jakob Syndrome
[Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid]
Creutzfeldt-Jakob Syndrome
[Diagnosis of transmissible spongiform encephalopathies in Spain. Population perspective]
Creutzfeldt-Jakob Syndrome
[MM1 variant of sporadic Creutzfeldt-Jakob disease with long duration akinetic mutism state]
Creutzfeldt-Jakob Syndrome
[New investigations in suspected Creutzfeldt-Jakob disease. Analysis of 14-3-3 protein and T-tau in cerebrospinal fluid for safer diagnosis]
Creutzfeldt-Jakob Syndrome
[Proportion of tau protein to phosphorylated tau protein CSF levels in differential diagnosis of dementia]
Creutzfeldt-Jakob Syndrome
[Study on the characteristic of Surveillant Creutzfeldt-Jakob disease patients from January to August in 2006 in China.]
Creutzfeldt-Jakob Syndrome
[Use and validity of the 14-3-3 protein test in the diagnosis of prion diseases: a 4-year prospective study]
Creutzfeldt-Jakob Syndrome
[Usefulness of the 14-3-3 test for the diagnosis of sCJD evaluated by a Spanish reference center.]
Crohn Disease
A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-? Release in Human Lymphoblasts.
Crohn Disease
A new avenue to investigate: the autophagic process. From Crohn's disease to Chlamydia.
Crohn Disease
An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.
Crohn Disease
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Crohn Disease
Corrigendum: Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn's Disease Development via the Upregulation of CARD3 Expression.
Crohn Disease
Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness.
Crohn Disease
Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo.
Crohn Disease
Disruption of LRRK2 in Zebrafish leads to hyperactivity and weakened antibacterial response.
Crohn Disease
Dysfunctional Crohn's Disease-Associated NOD2 Polymorphisms Cannot be Reliably Predicted on the Basis of RIPK2 Binding or Membrane Association.
Crohn Disease
Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus.
Crohn Disease
Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Crohn Disease
Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn's Disease Development via the Upregulation of CARD3 Expression.
Crohn Disease
Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.
Crohn Disease
Inflammatory bowel disease and Parkinson's disease: common pathophysiological links.
Crohn Disease
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
Crohn Disease
Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Crohn Disease
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Crohn Disease
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
Crohn Disease
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.
Crohn Disease
LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease.
Crohn Disease
LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.
Crohn Disease
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.
Crohn Disease
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
Crohn Disease
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Crohn Disease
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?
Crohn Disease
Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages.
Crohn Disease
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Crohn Disease
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Crohn Disease
Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis.
Crohn Disease
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Crohn Disease
The Neurobiology of LRRK2 and its Role in the Pathogenesis of Parkinson's Disease.
Crohn Disease
Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.
Cryptogenic Organizing Pneumonia
Post-Breast Cancer Radiotherapy Bronchiolitis Obliterans Organizing Pneumonia.
Cryptosporidiosis
5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.
Cryptosporidiosis
7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.
Cryptosporidiosis
A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis.
Cryptosporidiosis
Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
Cushing Syndrome
A genetic and molecular update on adrenocortical causes of Cushing syndrome.
Cushing Syndrome
A Novel Mutation in the type I? Regulatory Subunit of Protein Kinase A (PRKAR1A) in a Cushing's Syndrome Patient with Primary Pigmented Nodular Adrenocortical Disease.
Cushing Syndrome
A Novel PRKAR1A Mutation Identified in a Patient with Isolated Primary Pigmented Nodular Adrenocortical Disease.
Cushing Syndrome
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Cushing Syndrome
ARMC5 variants in PRKAR1A-mutated patients modify cortisol levels and Cushing's syndrome.
Cushing Syndrome
Correction: Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.
Cushing Syndrome
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Cushing Syndrome
Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome.
Cushing Syndrome
Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.
Cushing Syndrome
Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations.
Cushing Syndrome
Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.
Cushing Syndrome
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Cutis Laxa
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
cyclin-dependent kinase deficiency
CDKL5 Deficiency Disorder-A Complex Epileptic Encephalopathy.
cyclin-dependent kinase deficiency
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons.
cyclin-dependent kinase deficiency
Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?
Cystadenocarcinoma, Serous
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
Cystadenocarcinoma, Serous
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Cystadenoma, Serous
[Expression and significance of GLUT-1 and DNA-PKcs in serous ovarian tumors]
Cystic Fibrosis
A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gating.
Cystic Fibrosis
A SAXS-based ensemble model of the native and phosphorylated regulatory domain of the CFTR.
Cystic Fibrosis
Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity.
Cystic Fibrosis
Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Cardiomyocytes with disrupted CFTR function require CaMKII and Ca2+-activated Cl- channel activity to maintain contraction rate.
Cystic Fibrosis
Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia.
Cystic Fibrosis
CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells.
Cystic Fibrosis
Characterization and localization of the rabbit ocular calcitonin gene-related peptide (CGRP)-receptor component protein (RCP).
Cystic Fibrosis
Chenodeoxycholic Acid Requires Activation of EGFR, EPAC and Ca2+ to Stimulate CFTR-dependent Cl- Secretion in Human Colonic T84 Cells.
Cystic Fibrosis
Chloride secretory response to extracellular ATP in human normal and cystic fibrosis nasal epithelia.
Cystic Fibrosis
Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.
Cystic Fibrosis
Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.
Cystic Fibrosis
Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.
Cystic Fibrosis
Cyclic AMP-related and cation-affected human platelet chloride transport regulation.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle's syndrome mutations.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator is required for protein kinase A activation of an outwardly rectified anion channel purified from bovine tracheal epithelia.
Cystic Fibrosis
Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.
Cystic Fibrosis
Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells.
Cystic Fibrosis
Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating.
Cystic Fibrosis
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.
Cystic Fibrosis
External ATP and its analogs activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism.
Cystic Fibrosis
Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP.
Cystic Fibrosis
G protein G alpha i-2 inhibits outwardly rectifying chloride channels in human airway epithelial cells.
Cystic Fibrosis
Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by
Cystic Fibrosis
Hydrogen sulfide: A novel signaling molecule in the central nervous system.
Cystic Fibrosis
Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.
Cystic Fibrosis
Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels.
Cystic Fibrosis
Lactobacillus casei protects dextran sodium sulfate- or rapamycin-induced colonic inflammation in the mouse.
Cystic Fibrosis
Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility.
Cystic Fibrosis
Lysosomal Reacidification Ameliorates Vinyl Carbamate-Induced Toxicity and Disruption on Lysosomal pH.
Cystic Fibrosis
Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis.
Cystic Fibrosis
On the mechanism of genistein-induced activation of protein kinase A-dependent Cl- conductance in cardiac myocytes.
Cystic Fibrosis
Opiates inhibit ion conductances elicited by cell swelling and cAMP in cultured cells.
Cystic Fibrosis
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium.
Cystic Fibrosis
Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A.
Cystic Fibrosis
Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.
Cystic Fibrosis
PKC regulation of cardiac CFTR Cl- channel function in guinea pig ventricular myocytes.
Cystic Fibrosis
Properties of chloride-conductive pathways in rat kidney cortical and outer-medulla brush-border membranes--inhibition by anti-(cystic fibrosis transmembrane regulator) mAbs.
Cystic Fibrosis
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.
Cystic Fibrosis
Prostaglandin E2 induces chloride secretion through crosstalk between cAMP and calcium signaling in mouse inner medullary collecting duct cells.
Cystic Fibrosis
Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation.
Cystic Fibrosis
Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin.
Cystic Fibrosis
Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.
Cystic Fibrosis
Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site.
Cystic Fibrosis
Protein phosphorylation responses in normal and cystic fibrosis airway epithelial cell lines.
Cystic Fibrosis
R-Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator.
Cystic Fibrosis
Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi.
Cystic Fibrosis
Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model.
Cystic Fibrosis
Rectal epithelial expression of protein kinase A phosphorylation of cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis.
Cystic Fibrosis
Regulation of the ROMK channel: interaction of the ROMK with associate proteins.
Cystic Fibrosis
Removal of the Fe(iii) site promotes activation of the human cystic fibrosis transmembrane conductance regulator by high-affinity Zn(ii) binding.
Cystic Fibrosis
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.
Cystic Fibrosis
Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A.
Cystic Fibrosis
Role of the actin cytoskeleton in the regulation of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Small interfering peptide (siP) for in vivo examination of the developing lung interactonome.
Cystic Fibrosis
Stimulation of cystic fibrosis transmembrane conductance regulator-dependent short-circuit currents across DeltaF508 murine intestines.
Cystic Fibrosis
Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Structural features of Escherichia coli heat-stable enterotoxin that activates membrane-associated guanylyl cyclase.
Cystic Fibrosis
Targeted inactivation of cystic fibrosis transmembrane conductance regulator chloride channel gene prevents ischemic preconditioning in isolated mouse heart.
Cystic Fibrosis
The phorbol ester PMA and cyclic AMP activate different Cl(-) and HCO3(-) fluxes in C127 cells expressing CFTR.
Cystic Fibrosis
THE SHARK RECTAL GLAND MODEL: A CHAMPION OF RECEPTOR MEDIATED CHLORIDE SECRETION THROUGH CFTR.
Cystic Fibrosis
Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channels.
Cystic Fibrosis
Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.
Cystic Fibrosis
Type II protein kinase A regulates CFTR in airway, pancreatic, and intestinal cells.
Cystic Fibrosis
Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes.
Cystic Fibrosis
Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells.
Cysticercosis
Immunodiagnosis of porcine cysticercosis: identification of candidate antigens through immunoproteomics.
Cystitis
Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis.
Cystitis
Role of c-Jun N-Terminal Kinase (JNK) Activation in Micturition Reflexes in Cyclophosphamide (CYP)-Induced Cystitis in Female Rats.
Cystitis
The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis.
Cystitis, Interstitial
The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis.
Cysts
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
Cysts
14-3-3 protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid.
Cysts
A Pak-regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary.
Cysts
A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006-2016).
Cysts
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.
Cysts
Cold-induced cysts of the photosynthetic dinoflagellate Lingulodinium polyedrum have an arrested circadian bioluminescence rhythm and lower levels of protein phosphorylation.
Cysts
cut interacts with Notch and protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis.
Cysts
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys.
Cysts
Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.
Cysts
Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts.
Cysts
Enhanced resistance to soybean cyst nematode Heterodera glycines in transgenic soybean by silencing putative CLE receptors.
Cysts
Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.
Cysts
Immune responses and protection after DNA vaccination against Toxoplasma gondii calcium-dependent protein kinase 2 (TgCDPK2).
Cysts
Interaction network of the 14-3-3 protein in the ancient protozoan parasite Giardia duodenalis.
Cysts
Nematotoxicity of Paeonia spp. Extracts and Camellia oleifera Tea Seed Cake and Extracts to Heterodera glycines and Meloidogyne incognita.
Cysts
Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring.
Cysts
Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model.
Cysts
Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model.
Cysts
Relative expression of the 14-3-3 gene in different morphotypes of cysts of Echinococcus granulosus isolated from the Indian buffalo.
Cysts
Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.
Cysts
Synergistic Interaction of CLAVATA1, CLAVATA2, and RECEPTOR-LIKE PROTEIN KINASE 2 in Cyst Nematode Parasitism of Arabidopsis.
Cysts
The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.
Cysts
Yield and Clinical Utility of Next-Generation Sequencing in Selected Patients With Lung Adenocarcinoma.
Cytomegalovirus Infections
Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection.
Death, Sudden, Cardiac
A molecular formula for heart failure and sudden cardiac death. Focus on "Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice".
Death, Sudden, Cardiac
Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators.
Death, Sudden, Cardiac
Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors.
Death, Sudden, Cardiac
Synergy between CaMKII substrates and ?-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
Death, Sudden, Cardiac
The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias.
Dehydration
14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies.
Dehydration
A gene expression analysis of syncytia laser microdissected from the roots of the Glycine max (soybean) genotype PI 548402 (Peking) undergoing a resistant reaction after infection by Heterodera glycines (soybean cyst nematode).
Dehydration
Autophosphorylation and subcellular localization dynamics of a salt- and water deficit-induced calcium-dependent protein kinase from ice plant.
Dehydration
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments.
Dehydration
Effect of water stress on cell division and cell-division-cycle 2-like cell-cycle kinase activity in wheat leaves
Dehydration
Gene expression in two contrasting hybrid clones of Eucalyptus camaldulensis x Eucalyptus urophylla grown under water deficit conditions.
Dehydration
Involvement of 14-3-3 protein GRF9 in root growth and response under polyethylene glycol-induced water stress.
Dehydration
Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus.
Dehydration
Microbes in Cahoots with Plants: MIST to Hit the Jackpot of Agricultural Productivity during Drought.
Dehydration
Physiological and molecular responses for long term salinity stress in common fig (Ficus carica L.).
Dehydration
Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs.
Dementia
14-3-3 protein cerebrospinal fluid detection in human growth hormone-treated Creutzfeldt-Jakob disease patients.
Dementia
14-3-3 protein, total tau and phosphorylated tau in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease and neurodegenerative disease in Japan.
Dementia
14-3-3 {gamma}-isoform detection distinguishes sporadic Creutzfeldt-Jakob disease from other dementias.
Dementia
A practical approach to avoiding iatrogenic Creutzfeldt-Jakob disease (CJD) from invasive instruments.
Dementia
A rare case of rapidly progressive dementia with elevated RT-QuIC and negative 14-3-3 and tau proteins.
Dementia
A specific group of patients with diagnostic conversion from depression to bipolar disorder and finally to dementia as a mental GSK-3 disease: A hypothesis.
Dementia
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Dementia
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
Dementia
Additional value of tau protein measurement in the diagnosis of Creutzfeldt-Jakob disease.
Dementia
Alzheimer's and Hyperglycemia: Role of the Insulin Signaling Pathway and GSK-3 Inhibition in Paving a Path to Dementia.
Dementia
Analysis of 50 Neurodegenerative Genes in Clinically Diagnosed Early-Onset Alzheimer's Disease.
Dementia
Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt-Jakob Disease.
Dementia
Applicability of long-term electroencephalography in pre-mortem diagnosis of Creutzfeldt-Jakob disease: A case report.
Dementia
Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and creutzfeldt-jakob disease.
Dementia
Autopsy-diagnosed neurodegenerative dementia cases support the use of cerebrospinal fluid protein biomarkers in the diagnostic work-up.
Dementia
Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type.
Dementia
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Dementia
Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years.
Dementia
Cerebrospinal Fluid Biomarker-Based Diagnosis of Sporadic Creutzfeldt-Jakob Disease: A Validation Study for Previously Established Cutoffs.
Dementia
Cerebrospinal fluid biomarkers in clinically isolated syndromes and multiple sclerosis.
Dementia
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.
Dementia
Clinical range and MRI in Creutzfeldt-Jakob disease with heterozygosity at codon 129 and prion protein type 2.
Dementia
Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.
Dementia
Comatose within 6 weeks, but still alive after 3 years, Creutzfeldt-Jakob disease with unusual progression.
Dementia
Comparison between plasma and cerebrospinal fluid biomarkers for the early diagnosis and association with survival in prion disease.
Dementia
CSF detection of the 14-3-3 protein in unselected patients with dementia.
Dementia
Determination of 14-3-3 protein levels in cerebrospinal fluid from Creutzfeldt-Jakob patients by a highly sensitive capture assay.
Dementia
Development of a dot blot assay with antibodies to recombinant "core" 14-3-3 protein: Evaluation of its usefulness in diagnosis of Creutzfeldt-Jakob disease.
Dementia
Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients.
Dementia
Diagnostic value of surrogate CSF biomarkers for Creutzfeldt-Jakob disease in the era of RT-QuIC.
Dementia
Diffusion-weighted MRI in Creutzfeldt-Jakob disease: a better diagnostic marker than CSF protein 14-3-3?
Dementia
Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.
Dementia
Effect of Huannao Yicong Prescription () extract on ?-Amyloid precursor protein metabolic signal transduction-related protein in brain tissue of dementia model transgenic mouse.
Dementia
Ginkgo biloba leaf extract improves the cognitive abilities of rats with D-galactose induced dementia.
Dementia
Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.
Dementia
Glycogen synthase kinase-3 inhibition as a potential pharmacological target for vascular dementia: In silico and in vivo evidence.
Dementia
High Diagnostic Accuracy of RT-QuIC Assay in a Prospective Study of Patients with Suspected sCJD.
Dementia
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models.
Dementia
Identification of Three Novel LRRK2 Mutations associated with Parkinson's Disease in a Calabrian Population.
Dementia
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
Dementia
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Dementia
Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases.
Dementia
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Dementia
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Dementia
Lithium treatment and risk for dementia in adults with bipolar disorder: population-based cohort study.
Dementia
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.
Dementia
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Dementia
Magnetic resonance spectroscopy and measurement of tau epitopes of autopsy proven sporadic Creutzfeldt-Jakob disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 immunoblot.
Dementia
microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.
Dementia
Mutation Analysis of the Genes Associated with Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia.
Dementia
N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells.
Dementia
Novel prion protein gene mutation in an octogenarian with Creutzfeldt-Jakob disease.
Dementia
Pharmacological activation of protein kinase A improves memory loss and neuropathological changes in a mouse model of dementia of Alzheimer's type.
Dementia
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Dementia
PTEN? Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning.
Dementia
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Dementia
T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model.
Dementia
The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.
Dementia
The complex relationship between genotype, pathology and phenotype in familial dementia.
Dementia
The Missing Heritability of Sporadic Frontotemporal Dementia: New Insights from Rare Variants in Neurodegenerative Candidate Genes.
Dementia
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Dementia
[CSF analysis of patients with prion disease by biomarkers and real-time qucking-induced conversion (RT-QUIC) method].
Dementia
[Roles of Mammalian Target of Rapamycin Signaling and Autophagy Pathway in Alzheimer's Disease].
Dementia, Vascular
Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.
Dementia, Vascular
Effects of electroacupuncture on the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of rats with vascular dementia.
Dementia, Vascular
Glycogen synthase kinase-3 inhibition as a potential pharmacological target for vascular dementia: In silico and in vivo evidence.
Dementia, Vascular
LRRK2 G2019S and I2020T mutations are not common in Alzheimer's disease and vascular dementia.
Dementia, Vascular
Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.
Dementia, Vascular
Upregulated expression of 14-3-3 proteins in astrocytes from human cerebrovascular ischemic lesions.
Dementia, Vascular
[Eleven years of autopsy on account of Creutzfeldt-Jakob disease in the Netherlands]
Demyelinating Diseases
Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate.
Demyelinating Diseases
Biochemical markers of damage of the central nervous system in multiple sclerosis.
Demyelinating Diseases
Increased 14-3-3 immunoreactivity in glial elements in patients with multiple sclerosis.
Demyelinating Diseases
Increased activation of the epidermal growth factor receptor in transgenic mice overexpressing epigen causes peripheral neuropathy.
Demyelinating Diseases
The 14-3-3 protein in multiple sclerosis: a marker of disease severity.
Dengue
Cell death gene expression profile: role of RIPK2 in dengue virus-mediated apoptosis.
Dengue
Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation.
Dengue
Identification and characterization of the role of c-terminal Src kinase in dengue virus replication.
Dengue
IDENTIFICATION AND EXPRESSION ANALYSIS OF TWO 14-3-3 PROTEINS IN THE MOSQUITO Aedes aegypti, AN IMPORTANT ARBOVIRUSES VECTOR.
Dengue
Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia.
Dermatitis
Anti-inflammatory and immune response regulation of Si-Ni-San in 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction.
Dermatitis
Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway.
Dermatitis, Allergic Contact
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Dermatitis, Atopic
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Dermatitis, Atopic
Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches.
Dermatitis, Atopic
Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis.
Dermatitis, Atopic
Red ginseng extracts attenuate skin inflammation in atopic dermatitis through p70 ribosomal protein S6 kinase activation.
Dermatitis, Contact
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis.
Dermatofibrosarcoma
Alteration of PDGFR?-Akt-mTOR Pathway Signaling in Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans.
Diabetes Complications
Cutaneous expression of calcium/calmodulin-dependent protein kinase II in rats with type 1 and type 2 diabetes.
Diabetes Complications
Protein kinase C? activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.
Diabetes Insipidus
Expression of a dominant negative Protein Kinase A (PKA) mutation in kidney elicits a diabetes insipidus phenotype.
Diabetes Insipidus, Nephrogenic
Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus.
Diabetes Insipidus, Nephrogenic
GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.
Diabetes Insipidus, Nephrogenic
Lithium and nephrotoxicity: Unravelling the complex pathophysiological threads of the lightest metal.
Diabetes Mellitus
3D-QSAR and Molecular Docking Studies on 3-Anilino-4-Arylmaleimide Derivatives as Glycogen Synthase Kinase-3? Inhibitors.
Diabetes Mellitus
3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors.
Diabetes Mellitus
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Diabetes Mellitus
A proteoglycan extract from Ganoderma Lucidum protects pancreatic beta-cells against STZ-induced apoptosis.
Diabetes Mellitus
Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart.
Diabetes Mellitus
Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy.
Diabetes Mellitus
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Diabetes Mellitus
Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3? inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance.
Diabetes Mellitus
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus
Changes of calcium/calmodulin-dependent protein kinase II expression in dorsal root ganglia during maturation in long-term diabetes.
Diabetes Mellitus
Curcumin anti-diabetic effect mainly correlates with its anti-apoptotic actions and PI3K/Akt signal pathway regulation in the liver.
Diabetes Mellitus
Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-?B signaling pathways after streptozotocin-induced diabetes mellitus.
Diabetes Mellitus
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation.
Diabetes Mellitus
Dietary Methionine Restriction Alleviates Hyperglycemia in Pigs with Intrauterine Growth Restriction by Enhancing Hepatic Protein Kinase B Signaling and Glycogen Synthesis.
Diabetes Mellitus
Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.
Diabetes Mellitus
DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice.
Diabetes Mellitus
Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in early stage of type I diabetes mellitus through activation of JNK.
Diabetes Mellitus
Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
Diabetes Mellitus
Effects of Selenium and Exendin-4 on Glucagon-Like Peptide-1 Receptor, IRS-1, and Raf-1 in the Liver of Diabetic Rats.
Diabetes Mellitus
Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
Diabetes Mellitus
Expression characteristics of proteins of IGF-1R, p-Akt, and survivin in papillary thyroid carcinoma patients with type 2 diabetes mellitus.
Diabetes Mellitus
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Diabetes Mellitus
Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
Diabetes Mellitus
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review.
Diabetes Mellitus
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Diabetes Mellitus
GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics.
Diabetes Mellitus
Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.
Diabetes Mellitus
Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus.
Diabetes Mellitus
Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from Type II diabetic subjects.
Diabetes Mellitus
Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis.
Diabetes Mellitus
Kalpaamruthaa modulates oxidative stress in cardiovascular complication associated with type 2 diabetes mellitus through PKC-?/Akt signaling.
Diabetes Mellitus
Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice.
Diabetes Mellitus
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Diabetes Mellitus
LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats.
Diabetes Mellitus
Mechanism of improving effect of losartan on insulin sensitivity of non-insulin-dependent diabetes mellitus rats.
Diabetes Mellitus
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Diabetes Mellitus
New leads for selective GSK-3 inhibition: pharmacophore mapping and virtual screening studies.
Diabetes Mellitus
O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure.
Diabetes Mellitus
Oxidative CaMKII as a potential target for inflammatory disease (Review).
Diabetes Mellitus
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.
Diabetes Mellitus
PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
Diabetes Mellitus
Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.
Diabetes Mellitus
RNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty Rats.
Diabetes Mellitus
Role of Glycogen synthase kinase-3 in the etiology of Type 2 Diabetes Mellitus: A review.
Diabetes Mellitus
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
Diabetes Mellitus
Selectivity criterion for pyrazolo[3,4-b]pyrid[az]ine derivatives as GSK-3 inhibitors: CoMFA and molecular docking studies.
Diabetes Mellitus
Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats.
Diabetes Mellitus
Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.
Diabetes Mellitus
STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus.
Diabetes Mellitus
The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes.
Diabetes Mellitus
The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus.
Diabetes Mellitus
The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus.
Diabetes Mellitus
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Diabetes Mellitus
Valsartan improves cardiac function in mice with diabetes mellitus by CaMKII/AngII.
Diabetes Mellitus
[Genes and molecular mechanisms affecting the correlation between liver cancer and diabetes mellitus].
Diabetes Mellitus
[Modulating effects of protein kinase A on intracellular signal systems in the course of skin wound healing in patients with diabetes mellitus]
Diabetes Mellitus, Type 1
Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetes.
Diabetes Mellitus, Type 1
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Diabetes Mellitus, Type 1
In vivo effects of insulin and bis(maltolato)oxovanadium (IV) on PKB activity in the skeletal muscle and liver of diabetic rats.
Diabetes Mellitus, Type 1
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
Diabetes Mellitus, Type 2
?-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells.
Diabetes Mellitus, Type 2
A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes.
Diabetes Mellitus, Type 2
A proteoglycan extract from Ganoderma Lucidum protects pancreatic beta-cells against STZ-induced apoptosis.
Diabetes Mellitus, Type 2
Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy.
Diabetes Mellitus, Type 2
AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes.
Diabetes Mellitus, Type 2
AMPK in the small intestine in normal and pathophysiological conditions.
Diabetes Mellitus, Type 2
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta.
Diabetes Mellitus, Type 2
Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology.
Diabetes Mellitus, Type 2
Anti-obesity effects of 3-hydroxychromone derivative, a novel small-molecule inhibitor of glycogen synthase kinase-3.
Diabetes Mellitus, Type 2
Antisense inhibition of S6 kinase 1 produces improved glucose tolerance and is well tolerated for 4 weeks of treatment in rats.
Diabetes Mellitus, Type 2
Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape.
Diabetes Mellitus, Type 2
Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China.
Diabetes Mellitus, Type 2
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases.
Diabetes Mellitus, Type 2
Calmodulin dependent protein kinase II activation by exercise regulates saturated & unsaturated fatty acids and improves some metabolic syndrome markers.
Diabetes Mellitus, Type 2
CARD3 deficiency exacerbates diet-induced obesity, hepatosteatosis, and insulin resistance in male mice.
Diabetes Mellitus, Type 2
Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment.
Diabetes Mellitus, Type 2
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
Diabetes Mellitus, Type 2
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
Diabetes Mellitus, Type 2
Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.
Diabetes Mellitus, Type 2
Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.
Diabetes Mellitus, Type 2
Curcumin anti-diabetic effect mainly correlates with its anti-apoptotic actions and PI3K/Akt signal pathway regulation in the liver.
Diabetes Mellitus, Type 2
Depletion of PAK1 enhances Ubiquitin-mediated Survivin degradation in pancreatic ?-cells.
Diabetes Mellitus, Type 2
Detection of active fraction of glycogen synthase kinase 3beta in cancer cells by nonradioisotopic in vitro kinase assay.
Diabetes Mellitus, Type 2
Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.
Diabetes Mellitus, Type 2
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
Diabetes Mellitus, Type 2
Dietary Methionine Restriction Alleviates Hyperglycemia in Pigs with Intrauterine Growth Restriction by Enhancing Hepatic Protein Kinase B Signaling and Glycogen Synthesis.
Diabetes Mellitus, Type 2
DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice.
Diabetes Mellitus, Type 2
Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes.
Diabetes Mellitus, Type 2
Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.
Diabetes Mellitus, Type 2
Effects of CaMKII-Mediated Phosphorylation of Ryanodine Receptor Type 2 on Islet Calcium Handling, Insulin Secretion, and Glucose Tolerance.
Diabetes Mellitus, Type 2
Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
Diabetes Mellitus, Type 2
Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats.
Diabetes Mellitus, Type 2
Exendin-4 stimulates autophagy in pancreatic ?-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis.
Diabetes Mellitus, Type 2
Expression characteristics of proteins of IGF-1R, p-Akt, and survivin in papillary thyroid carcinoma patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Diabetes Mellitus, Type 2
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Diabetes Mellitus, Type 2
Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3 - a promising therapeutic target: Dr Hagit Eldar-Finkelman interviewed by Emma Quigley.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3 as drug target: from wallflower to center of attention.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Diabetes Mellitus, Type 2
Glycogen synthase kinase-3: The missing link to aberrant circuit function in disorders of cognitive dysfunction?
Diabetes Mellitus, Type 2
GSK-3 as potential target for therapeutic intervention in cancer.
Diabetes Mellitus, Type 2
GSK-3 Inhibitors: A new class of drugs for Alzheimer's Disease Treatment.
Diabetes Mellitus, Type 2
High glucose and insulin in combination cause insulin receptor substrate-1 and -2 depletion and protein kinase B desensitisation in primary cultured rat adipocytes: possible implications for insulin resistance in type 2 diabetes.
Diabetes Mellitus, Type 2
Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment.
Diabetes Mellitus, Type 2
In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity.
Diabetes Mellitus, Type 2
In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes.
Diabetes Mellitus, Type 2
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Diabetes Mellitus, Type 2
Individual Radiosensitivity Assessment of the Families of Ataxia-Telangiectasia Patients by G2-Checkpoint Abrogation.
Diabetes Mellitus, Type 2
Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Diabetes Mellitus, Type 2
Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.
Diabetes Mellitus, Type 2
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Diabetes Mellitus, Type 2
Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3.
Diabetes Mellitus, Type 2
Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review.
Diabetes Mellitus, Type 2
Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis.
Diabetes Mellitus, Type 2
Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction.
Diabetes Mellitus, Type 2
Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.
Diabetes Mellitus, Type 2
Interactive Association Between Intronic Polymorphism (rs10506151) of the LRRK2 Gene and Type 2 Diabetes on Neurodegenerative Diseases.
Diabetes Mellitus, Type 2
Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model.
Diabetes Mellitus, Type 2
Kalpaamruthaa modulates oxidative stress in cardiovascular complication associated with type 2 diabetes mellitus through PKC-?/Akt signaling.
Diabetes Mellitus, Type 2
LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats.
Diabetes Mellitus, Type 2
Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor Improves Glucose Homeostasis in ob/ob Mice: Molecular Characterization in Liver and Muscle.
Diabetes Mellitus, Type 2
Mapping and association studies of diabetes related genes in the pig.
Diabetes Mellitus, Type 2
Mechanism of improving effect of losartan on insulin sensitivity of non-insulin-dependent diabetes mellitus rats.
Diabetes Mellitus, Type 2
Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury.
Diabetes Mellitus, Type 2
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet ?-cells.
Diabetes Mellitus, Type 2
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Diabetes Mellitus, Type 2
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Diabetes Mellitus, Type 2
Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders.
Diabetes Mellitus, Type 2
PLS and shape-based similarity analysis of maleimides - GSK-3 inhibitors.
Diabetes Mellitus, Type 2
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Diabetes Mellitus, Type 2
PPAR? promotes diabetes-associated centrosome amplification via increasing the expression of SKA1 directly at the transcriptional level.
Diabetes Mellitus, Type 2
PRAS40: target or modulator of mTORC1 signalling and insulin action?
Diabetes Mellitus, Type 2
Protection of INS-1 cells from free fatty acid-induced apoptosis by inhibiting the glycogen synthase kinase-3.
Diabetes Mellitus, Type 2
Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo.
Diabetes Mellitus, Type 2
Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.
Diabetes Mellitus, Type 2
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
Diabetes Mellitus, Type 2
RNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty Rats.
Diabetes Mellitus, Type 2
Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes.
Diabetes Mellitus, Type 2
Role of CaMKII in the regulation of fatty acids and lipid metabolism.
Diabetes Mellitus, Type 2
Role of exercise-induced calmodulin protein kinase (CAMK)II activation in the regulation of omega-6 fatty acids and lipid metabolism genes in rat skeletal muscle.
Diabetes Mellitus, Type 2
Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
Diabetes Mellitus, Type 2
Role of glycogen synthase kinase-3 in skeletal muscle insulin resistance in Type 2 diabetes.
Diabetes Mellitus, Type 2
Role of Glycogen synthase kinase-3 in the etiology of Type 2 Diabetes Mellitus: A review.
Diabetes Mellitus, Type 2
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance.
Diabetes Mellitus, Type 2
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
Diabetes Mellitus, Type 2
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
Diabetes Mellitus, Type 2
Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
Diabetes Mellitus, Type 2
Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats.
Diabetes Mellitus, Type 2
Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply.
Diabetes Mellitus, Type 2
Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes.
Diabetes Mellitus, Type 2
STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome.
Diabetes Mellitus, Type 2
Structural basis for compound C inhibition of the human AMP-activated protein kinase ?2 subunit kinase domain.
Diabetes Mellitus, Type 2
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes.
Diabetes Mellitus, Type 2
The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin.
Diabetes Mellitus, Type 2
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
Diabetes Mellitus, Type 2
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.
Diabetes Mellitus, Type 2
The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
Diabetes Mellitus, Type 2
Tissue-specific analysis of glycogen synthase kinase-3? (GSK-3?) in glucose metabolism: effect of strain variation.
Diabetes Mellitus, Type 2
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Diabetes Mellitus, Type 2
Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes.
Diabetes Mellitus, Type 2
Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3?.
Diabetes Mellitus, Type 2
[Modulating effects of protein kinase A on intracellular signal systems in the course of skin wound healing in patients with diabetes mellitus]
Diabetes, Gestational
A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation.
Diabetes, Gestational
Effects of insulin intervention on the expression of VE-cadherin, ?-catenin, Annexin A2, Annexin A5, and 14-3-3 protein in the placentas of patients with gestational diabetes mellitus.
Diabetes, Gestational
Expression of PI3-K, PKB and GSK-3 ? in the skeletal muscle tissue of gestational diabetes mellitus.
Diabetes, Gestational
The genetic polymorphism in the STK11 does not affect gestational diabetes.
Diabetes, Gestational
Vanadate enhances but does not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus.
Diabetic Angiopathies
Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis.
Diabetic Cardiomyopathies
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Activation of HIF-1 by metallothionein contributes to cardiac protection in the diabetic heart.
Diabetic Cardiomyopathies
Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
Diabetic Cardiomyopathies
Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.
Diabetic Cardiomyopathies
CaMKII Inhibition is a Novel Therapeutic Strategy to Prevent Diabetic Cardiomyopathy.
Diabetic Cardiomyopathies
CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol.
Diabetic Cardiomyopathies
Inactivation of GSK-3{beta} by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage and remodeling.
Diabetic Cardiomyopathies
Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression.
Diabetic Cardiomyopathies
Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model.
Diabetic Cardiomyopathies
Protein Kinases as Drug Development Targets for Heart Disease Therapy.
Diabetic Cardiomyopathies
RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation.
Diabetic Cardiomyopathies
Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3? and p38?/MAPK in a rat model of diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Transplanted bone marrow mesenchymal stem cells protects myocardium by regulating 14-3-3 protein in a rat model of diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Valsartan improves cardiac function in mice with diabetes mellitus by CaMKII/AngII.
Diabetic Nephropathies
Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease.
Diabetic Nephropathies
Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology.
Diabetic Nephropathies
Apoptosis occurs differentially according to glomerular size in diabetic kidney disease.
Diabetic Nephropathies
Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway.
Diabetic Nephropathies
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
Diabetic Nephropathies
Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells.
Diabetic Nephropathies
Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system.
Diabetic Nephropathies
Lycopene ameliorates renal function in rats with streptozotocin-induced diabetes.
Diabetic Nephropathies
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.
Diabetic Nephropathies
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Diabetic Nephropathies
Resveratrol attenuates renal hypertrophy in early-stage diabetes by activating AMPK.
Diabetic Nephropathies
RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose.
Diabetic Nephropathies
Rituximab regulates the expression of the Raf kinase inhibitor protein via NF-?B in renal tissue of rats with diabetic nephropathy.
Diabetic Nephropathies
ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy.
Diabetic Nephropathies
Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.
Diabetic Nephropathies
Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.
Diabetic Nephropathies
The effects of microRNA-126 reduced inflammation and apoptosis of diabetic nephropathy through PI3K/AKT signalling pathway by VEGF.
Diabetic Neuropathies
Diabetes-Induced Mechanical Hyperalgesia Involves Spinal Mitogen-Activated Protein Kinase Activation in Neurons and Microglia via N-Methyl-D-aspartate-Dependent Mechanisms.
Diabetic Neuropathies
Intrathecal inhibition of calcium/calmodulin-dependent protein kinase II in diabetic neuropathy adversely affects pain-related behavior.
Diabetic Neuropathies
Metabolic effect of PGE1 analogue 01206.alpha CD on nerve Na(+)-K(+)-ATPase activity of rats with streptozocin-induced diabetes is mediated via cAMP: possible role of cAMP in diabetic neuropathy.
Diabetic Neuropathies
Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model.
Diabetic Neuropathies
Real-Time Translocation and Function of PKC?II Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor.
Diabetic Neuropathies
The effects of intraganglionic injection of calcium/calmodulin-dependent protein kinase II inhibitors on pain-related behavior in diabetic neuropathy.
Diabetic Neuropathies
The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes.
Diabetic Retinopathy
Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy.
Diabetic Retinopathy
Glycogen synthase kinase-3: a key kinase in retinal neuron apoptosis in early diabetic retinopathy.
Diabetic Retinopathy
RKIP negatively regulates the glucose induced angiogenesis and endothelial-mesenchymal transition in retinal endothelial cells.
Diabetic Retinopathy
Role of raf-1 kinase in diabetes-induced accelerated apoptosis of retinal capillary cells.
Diffuse Intrinsic Pontine Glioma
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
DiGeorge Syndrome
Circadian rhythm genes in cancer: insight into their functions and regulation involving noncoding RNAs.
Digestive System Neoplasms
Serine/threonine kinase 15 gene polymorphism and risk of digestive system cancers: A meta-analysis.
Disorders of Excessive Somnolence
Clustering of motor and nonmotor traits in leucine-rich repeat kinase 2 G2019S Parkinson's disease nonparkinsonian relatives: A multicenter family study.
Disorders of Excessive Somnolence
Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease.
Distemper
Phosphorylation of canine distemper virus P protein by protein kinase C-zeta and casein kinase II.
DNA Repair-Deficiency Disorders
Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells.
DNA Repair-Deficiency Disorders
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
DNA Virus Infections
A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus.
DNA Virus Infections
Roles of GSK-3 and ?-Catenin in Antiviral Innate Immune Sensing of Nucleic Acids.
DNA Virus Infections
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.
Down Syndrome
Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21).
Down Syndrome
Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase.
Down Syndrome
Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.
Down Syndrome
Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.
Down Syndrome
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Down Syndrome
Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein.
Down Syndrome
DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.
Down Syndrome
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.
Down Syndrome
Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-kappaB in brains of patients with Down syndrome.
Down Syndrome
Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients.
Down Syndrome
Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins.
Down Syndrome
Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down syndrome.
Down Syndrome
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Down Syndrome
Kinetic Properties of a MNB/DYRK1A Mutant Suitable for the Elucidation of Biochemical Pathways.
Down Syndrome
Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain.
Down Syndrome
Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins.
Down Syndrome
MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins.
Down Syndrome
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.
Down Syndrome
Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex.
Down Syndrome
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome.
Down Syndrome
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry.
Down Syndrome
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Down Syndrome
Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.
Drug Resistant Epilepsy
The Putative Role of mTOR Inhibitors in Non-tuberous Sclerosis Complex-Related Epilepsy.
Drug Resistant Epilepsy
What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.
Drug-Related Side Effects and Adverse Reactions
A role for survivin in chemoresistance of endothelial cells mediated by VEGF.
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Duodenal Neoplasms
Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene.
Dwarfism
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
Dyskinesias
A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia.
Dyskinesias
A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson disease.
Dyskinesias
CaMKII inhibition ameliorated levodopa-induced dyskinesia by downregulating tyrosine hydroxylase activity in an experimental model of Parkinson's disease.
Dyskinesias
Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia.
Dyskinesias
Dyskinesias in patients with Parkinson's disease: Effect of the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation.
Dyskinesias
Greater improvement in LRRK2 G2019S patients undergoing Subthalamic Nucleus Deep Brain Stimulation compared to non-mutation carriers.
Dyskinesias
Interactions of CaMKII with dopamine D2 receptors: roles in levodopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's rats.
Dyskinesias
Is the common LRRK2 G2019S mutation related to dyskinesias in North African Parkinson disease?
Dyskinesias
LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias.
Dyskinesias
Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys.
Dyskinesias
Striatal leucine-rich repeat kinase 2 mRNA is increased in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned common marmosets (Callithrix jacchus) with L-3, 4-dihydroxyphenylalanine methyl ester-induced dyskinesia.
Dyskinesias
Understanding the role of glycogen synthase kinase-3 in L-DOPA-induced dyskinesia in Parkinson's disease.
Dyslipidemias
Ameliorative effect of low-dose spironolactone on obesity and insulin resistance is through replenishment of estrogen in ovariectomized rats.
Dyslipidemias
Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy.
Dyslipidemias
Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats.
Dyslipidemias
Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia.
Dyslipidemias
Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice.
Dyslipidemias
Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice.
Dysplastic Nevus Syndrome
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas).
Dysplastic Nevus Syndrome
Outcomes of endoscopic ultrasound as a one-off pancreatic cancer screening tool for 122 high- and moderate-risk patients.
Dysplastic Nevus Syndrome
Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases.
Dystonia
A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation.
Dystonia
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Dystonic Disorders
Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan.
e2 ubiquitin-conjugating enzyme deficiency
Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase.
Echinococcosis
Characterization of 14-3-3 isoforms expressed in the Echinococcus granulosus pathogenic larval stage.
Echinococcosis
The Echinococcus multilocularis 14-3-3 protein protects mice against primary but not secondary alveolar echinococcosis.
Encephalitis
Anti-SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome: Studies in 8 stuporous and comatose patients.
Encephalitis
Differential activation of the c-Jun N-terminal kinase/stress-activated protein kinase and p38 mitogen-activated protein kinase signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus.
Encephalitis
Effects of isoflurane on brain inflammation after subarachnoid hemorrhage in mice.
Encephalitis
Fas-mediated apoptotic signaling in the mouse brain following reovirus infection.
Encephalitis
Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection.
Encephalitis
Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase.
Encephalitis
Increased concentrations of 14-3-3 epsilon, gamma and zeta isoforms in cerebrospinal fluid of AIDS patients with neuronal destruction.
Encephalitis
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Encephalitis
Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
Encephalitis
Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis.
Encephalitis, Japanese
Antisense Oligonucleotides Targeting Raf-1 Block Japanese Encephalitis Virus In Vitro and In Vivo.
Encephalitis, Japanese
p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalitis, Viral
Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease.
Encephalomyelitis
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.
Encephalomyelitis
c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis
Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.
Encephalomyelitis
Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.
Encephalomyelitis
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
Encephalomyelitis
RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling.
Encephalomyelitis
Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.
Encephalomyelitis
Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.
Encephalomyelitis, Autoimmune, Experimental
c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.
Encephalomyelitis, Autoimmune, Experimental
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.
Encephalomyelitis, Autoimmune, Experimental
RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling.
Encephalomyelitis, Autoimmune, Experimental
Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Encephalomyelitis, Autoimmune, Experimental
Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis.
Encephalopathy, Bovine Spongiform
Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent.
Enchondromatosis
IDH1 immunohistochemistry reactivity and mosaic IDH1 or IDH2 somatic mutations in pediatric sporadic enchondroma and enchondromatosis.
Endocrine Gland Neoplasms
Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target.
Endometrial Hyperplasia
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Endometrial Hyperplasia
High level of visfatin and the activation of Akt and ERK1/2 signaling pathways are associated with endometrium malignant transformation in polycystic ovary syndrome.
Endometrial Hyperplasia
Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant group.
Endometrial Neoplasms
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol.
Endometrial Neoplasms
ATM mutations as an independent prognostic factor and potential biomarker for immune checkpoint therapy in endometrial cancer.
Endometrial Neoplasms
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
Endometrial Neoplasms
c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells.
Endometrial Neoplasms
CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells.
Endometrial Neoplasms
Cross-talk between p21-activated kinase 4 and ER? signaling triggers endometrial cancer cell proliferation.
Endometrial Neoplasms
Crosstalk between NF-kappaB/p65 and beta-catenin/TCF4/p300 signalling pathways through alterations in GSK-3beta expression during trans-differentiation of endometrial carcinoma cells.
Endometrial Neoplasms
Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma.
Endometrial Neoplasms
Expression of HER-2 affects patient survival and paclitaxel sensitivity in endometrial cancer.
Endometrial Neoplasms
Expression of phosphorylated Akt, mTOR and MAPK in type I endometrial carcinoma: clinical significance.
Endometrial Neoplasms
Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma.
Endometrial Neoplasms
Inhibition of Expression of the S100A8 Gene Encoding the S100 Calcium-Binding Protein A8 Promotes Apoptosis by Suppressing the Phosphorylation of Protein Kinase B (Akt) in Endometrial Carcinoma and HEC-1A Cells.
Endometrial Neoplasms
Luteinizing hormone increases human endometrial cancer cells invasiveness through activation of protein kinase A.
Endometrial Neoplasms
Metformin is associated with reduced cell proliferation in human endometrial cancer by inbibiting PI3K/AKT/mTOR signaling.
Endometrial Neoplasms
MicroRNA-135a promotes proliferation, migration, invasion and induces chemoresistance of endometrial cancer cells.
Endometrial Neoplasms
MicroRNA-200c Inhibits Epithelial-Mesenchymal Transition by Targeting the BMI-1 Gene Through the Phospho-AKT Pathway in Endometrial Carcinoma Cells In Vitro.
Endometrial Neoplasms
MiR-200a and miR-200b target PTEN to regulate the endometrial cancer cell growth in vitro.
Endometrial Neoplasms
Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma.
Endometrial Neoplasms
p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion.
Endometrial Neoplasms
Protein kinase C-independent stimulation of activator protein-1 and c-Jun N-terminal kinase activity in human endometrial cancer cells by the LHRH agonist triptorelin.
Endometrial Neoplasms
PTEN is involved in the signal transduction pathway of contact inhibition in endometrial cells.
Endometrial Neoplasms
PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma.
Endometrial Neoplasms
Relevance of lipogenesis and AMPK/Akt/mTOR signaling pathway in endometrial cancer.
Endometrial Neoplasms
Requirement of the Akt/{beta}-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug.
Endometrial Neoplasms
[Correlations of p-AKT with PTEN, P53, HER-2 expressions in endometrial carcinoma and their relationship with patient survival].
Endometrial Neoplasms
[Effect of phorbol ester on tissue-type plasminogen activator (t-PA) secretion in endometrial carcinoma cell line in vitro]
Endometrial Neoplasms
[Effects of PD98059 and LY294002 on subcutaneous xenograft of human endometrial carcinoma in nude mice].
Endometrial Neoplasms
[shRNA-Mediated Suppression of ?-Synuclein Leading to Downregulation of p38/ERK/JNK Phosphorylation and Cell Cycle Arrest in Endometrial Cancer Cells].
Endometriosis
Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis.
Endometriosis
Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models.
Endometriosis
Dysregulation of miR-202-3p Affects Migration and Invasion of Endometrial Stromal Cells in Endometriosis via Targeting ROCK1.
Endometriosis
Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model.
Endometriosis
Endometrial fluid is a specific and non-invasive biological sample for protein biomarker identification in endometriosis.
Endometriosis
Expression patterns of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors determined using an endometriosis tissue microarray model.
Endometriosis
Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness of endometrial stromal cells via the activation of JNK signaling pathway.
Endometriosis
Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes.
Endometriosis
Inhibition of MAPK and VEGFR by Sorafenib Controls the Progression of Endometriosis.
Endometriosis
Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women.
Endometriosis
Panel of Autoimmune Markers for Noninvasive Diagnosis of Minimal-Mild Endometriosis: A Multicenter Study.
Endometriosis
PI3K/AKT pathway is altered in the endometriosis patient's endometrium and presents differences according to severity stage.
Endometriosis
Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway.
Endometriosis
Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis.
Endometriosis
Protein kinase CK2 participates in estrogen-mediated endothelial progenitor cell homing to endometriotic lesions through stromal cells in a stromal cell-derived factor-1- CXCR4-dependent manner.
Endometriosis
Raf-1 levels determine the migration rate of primary endometrial stromal cells of patients with endometriosis.
Endometriosis
Raf-1, a potential therapeutic target, mediates early steps in endometriosis lesion development by endometrial epithelial and stromal cells.
Endometriosis
Regulation of P21-activated kinase-4 by progesterone and tumor necrosis factor-? in human endometrium and its increased expression in advanced-stage endometriosis.
Endometriosis
RNAi-mediated blocking of ezrin reduces migration of ectopic endometrial cells in endometriosis.
Endometriosis
The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis.
Endometriosis
Unremitting cell proliferation in the secretory phase of eutopic endometriosis: involvement of pAkt and pGSK3?.
Endotoxemia
Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia.
Endotoxemia
GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.
Endotoxemia
HIPK2 phosphorylates HDAC3 for NF-?B acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.