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EC Tree
IUBMB Comments Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
The taxonomic range for the selected organisms is: Arabidopsis thaliana The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase,
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receptor protein kinase CLAVATA1 precursor
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70 kDa zeta-associated protein
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Agammaglobulinaemia tyrosine kinase
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Amylovoran biosynthesis membrane-associated protein amsA
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B cell progenitor kinase
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B lymphocyte kinase
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B-cell/myeloid kinase
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BCR-ABL tyrosine kinase
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BMP type II receptor
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BMP-2/BMP-4 receptor
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Bone marrow kinase BMX
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Breast tumor kinase
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Bruton's tyrosine kinase
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Calcium-dependent tyrosine kinase
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Cell adhesion kinase beta
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ectoprotein kinase
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Epithelial and endothelial tyrosine kinase
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EPS I polysaccharide export protein epsB
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focal adhesion kinase 1
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gene lck protein kinase
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gene lck tyrosine kinase
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Hematopoietic consensus tyrosine-lacking kinase
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Hemopoietic cell kinase
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IL-2-inducible T-cell kinase
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JAK protein tyrosine kinase
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kinase, protein (phosphorylating tyrosine)
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kinase, protein p56lck (phosphorylating)
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Lck Tyrosine kinase
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Leukocyte janus kinase
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nonreceptor protein tyrosine kinase
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Nuclear tyrosine protein kinase RAK
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p56lck protein kinase
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p56lck protein tyrosine kinase
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p56lck tyrosine kinase
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phosphotyrosyl-protein kinase
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Protein kinase (tyrosine-phosphorylating)
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Protein kinase BATK
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Protein kinase HYL
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Protein kinase Lck
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Protein kinase NTK
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Protein kinase p56-LCK
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Protein kinase p56lck
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Protein p56c-lck kinase
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Protein p56lck tyrosine kinase
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Protein tyrosine kinase
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protein tyrosine kinase 2beta
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Protein tyrosine kinase lck
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Protein tyrosine kinase p56lck
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Protein tyrosine kinase pp56lck
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Protein-tyrosine kinase C-TKL
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Protein-tyrosine kinase CYL
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receptor-like protein kinase 5 precursor
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Related adhesion focal tyrosine kinase
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Resting lymphocyte kinase
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S-domain receptor-like protein kinase
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Spleen tyrosine kinase
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SRC-related intestinal kinase
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Syk-related tyrosine kinase
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T cell-specific protein-tyrosine kinase
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T-cell-specific kinase
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Tyrosine kinase ARG
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Tyrosine kinase lck
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Tyrosine kinase p56lck
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Tyrosine phosphokinase
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Tyrosine protein kinase
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Tyrosine protein kinase p56lck
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Tyrosine-protein kinase brk
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Tyrosine-protein kinase CTK
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Tyrosine-protein kinase Lyk
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Tyrosine-protein kinase TYRO 10
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Tyrosine-specific protein kinase
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Tyrosylprotein kinase
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v-fps Protein-tyrosine kinase
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YES related kinase
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phospho group transfer
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ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
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114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
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ATP + a protein
ADP + a phosphoprotein
the enzyme controls shoot and floral meristem size
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?
ATP + a protein
ADP + a phosphoprotein
ATP + casein
ADP + phosphocasein
serine/threonine kinase activity, and no tyrosine kinase activity
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ATP + enolase
ADP + ?
serine/threonine kinase activity, and no tyrosine kinase activity
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ATP + myosin light chain
ADP + ?
serine/threonine kinase activity, and no tyrosine kinase activity
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ATP + a protein
ADP + a phosphoprotein
autophosphorylation
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ATP + a protein
ADP + a phosphoprotein
autophosphorylation
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ATP + a protein
ADP + a phosphoprotein
phosphorylates tyrosine, serine and threonine
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ATP + a protein
ADP + a phosphoprotein
enzyme contributes to signal transduction
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ATP + a protein
ADP + a phosphoprotein
the enzyme controls shoot and floral meristem size
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?
ATP + a protein
ADP + a phosphoprotein
enzyme contributes to signal transduction
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?
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Mg2+
significantly greater activity in the presence of Mn2+ than Mg2+
Mn2+
significantly greater activity in the presence of Mn2+ than Mg2+
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SwissProt
brenda
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brenda
RLK5 protein contains an extracellular domain that has 21 tandemly repeated leucine-rich motifs linked, via a transmembrane hydrophobic region
brenda
membrane spanning enzyme
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CLV1_ARATH
980
1
107598
Swiss-Prot
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lipoprotein
N-myristoylation
phosphoprotein
several sites in the catalytic domain are phosphorylated
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K711E
substitution in the catalytic domain of RLK5 results in the catalytically inactive protein
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expression in Escherichia coli
expression of the catalytic domain as two different recombinant fusion proteins in Escherichia coli
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Theologis, A.; Ecker, J.R.; Palm, C.J.; et al.
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana
Nature
408
816-820
2000
Arabidopsis thaliana (Q06548), Arabidopsis thaliana (Q9SYQ8)
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Mayer, K.; Schuller, C.; Wambutt, R.; Murphy, G.; et al.
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Nature
402
769-777
1999
Arabidopsis thaliana (P47735)
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Lin, X.; Kaul, S.; Rounsley, S.; Shea, T.P.; Benito, M.I.; Town, C.D.; Fujii, C.Y.; Mason, T.; Bowman, C.L.; Barnstead, M.; Feldblyum, T.V.; Buell, C.R.; Ketchum, K.A.; Lee, J.; Ronning, C.M.; Koo, H.L.; Moffat, K.S.; Cronin, L.A.; Shen, M.; Pai, G.; Van Aken, S.; Umayam, L.; Tallon, L.J.; Gill, J.E.; Venter, J.C.; et al.
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana
Nature
402
761-768
1999
Arabidopsis thaliana (P46573)
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Hirayama, T.; Oka, A.
Novel protein kinase of Arabidopsis thaliana (APK1) that phosphorylates tyrosine, serine and threonine
Plant Mol. Biol.
20
653-662
1992
Arabidopsis thaliana (P46573), Arabidopsis thaliana (Q06548)
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Horn, M.A.; Walker, J.C.
Biochemical properties of the autophosphorylation of RLK5, a receptor-like protein kinase from Arabidopsis thaliana
Biochim. Biophys. Acta
1208
65-74
1994
Arabidopsis thaliana (P47735)
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Walker, J.C.
Receptor-like protein kinase genes of Arabidopsis thaliana
Plant J.
3
451-456
1993
Arabidopsis thaliana (P47735)
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Clark, S.E.; Williams, R.W.; Meyerowitz, E.M.
The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis
Cell
89
575-585
1997
Arabidopsis thaliana (Q9SYQ8)
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Williams, R.W.; Clark, S.E.; Meyerowitz, E.M.
Genetic and physical characterization of a region of Arabidopsis chromosome 1 containing the CLAVATA1 gene
Plant Mol. Biol.
39
171-176
1999
Arabidopsis thaliana (Q9SYQ8)
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