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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Bos taurus and UniProt Accession Q95126
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2.7.10.2 non-specific protein-tyrosine kinaseIUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Word Map
- 2.7.10.2
- leukemia
- imatinib
- lymphocytic
- integrins
-
myelogenous
- metastasis
- t-cells
-
cytogenetic
-
philadelphia
- mapks
- lymphoma
- sh2
- cytoskeleton
- erk
- phosphatidylinositol
- lymphoblastic
- adhesions
-
signal-regulated
-
myeloproliferative
- 3-kinase
- autophosphorylation
- paxillin
- dasatinib
- hematologic
- collagen
-
stats
-
remiss
- arthritis
- fibronectin
- neoplasm
-
relapse
-
tyrosine-phosphorylated
- oncoproteins
-
platelet-derived
- pkc
- phosphotyrosine
-
rheumatoid
-
dominant-negative
- adaptor
- mesylate
-
allogeneic
- factor-beta
-
breakpoints
-
integrin-mediated
- cd4
- crisis
- c-kit
-
activins
- drug development
- synthesis
- medicine
- analysis
- pharmacology
- pdgfr
-
kinase-dependent
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
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CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
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-
-
-
Cell adhesion kinase beta
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-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
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EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
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Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
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JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
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Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
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-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
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Nuclear tyrosine protein kinase RAK
-
-
-
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ORF6
-
-
-
-
p150
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-
-
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p55-BLK
-
-
-
-
P55-FGR
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-
-
-
p56-HCK
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-
-
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p56-HCK/p59-HCK
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-
-
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P56-LCK
-
-
-
-
p56lck kinase
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-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
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-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
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P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
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PP125FAK
-
-
-
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Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
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Protein kinase BATK
-
-
-
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Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
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Protein kinase NTK
-
-
-
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Protein kinase p56-LCK
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-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
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-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
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-
-
-
protein tyrosine kinase 2beta
-
-
-
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Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
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PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
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Related adhesion focal tyrosine kinase
-
-
-
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Resting lymphocyte kinase
-
-
-
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Rlk/Txk
-
-
-
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S-domain receptor-like protein kinase
-
-
-
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SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins
-
-
?
additional information
?
-
-
enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins
-
-
?
additional information
?
-
-
enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins
-
-
?
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
decreasing levels of the bovine activin type II receptor mRNA with testes maturation
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
alternative splicing is responsible for the generation of these bActRIIB isoforms
additional information
-
alternative splicing is responsible for the generation of these bActRIIB isoforms
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ethier, J.F.; Lussier, J.G.; Silversides, D.W.
Bovine activin receptor type IIB messenger ribonucleic acid displays alternative splicing involving a sequence homologous to Src-homology 3 domain binding sites
Endocrinology
138
2425-2434
1997
Bos taurus (Q95126), Bos taurus
Monteagudo, L.V.; Heriz, A.; Flavin, N.; Rogers, M.; Ennis, S.; Arruga, M.V.
Fluorescent in situ localization of the bovine activin receptor type IIA locus on chromosome 2 (2q2.3-2.4)
Mamm. Genome
7
869
1996
Bos taurus (Q28043), Bos taurus
Ethier, J.F.; Houde, A.; Lussier, J.G.; Silversides, D.W.
Bovine activin receptor type II cDNA cloning and tissue expression
Mol. Cell. Endocrinol.
106
1-8
1994
Bos taurus (Q28043), Bos taurus
EXTERNAL LINKS (specific for EC-Number 2.7.10.2)
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