Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Xenopus laevis and UniProt Accession Q91738

for references in articles please use BRENDA:EC2.7.10.2
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Xenopus laevis
UNIPROT: Q91738
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Xenopus laevis
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70 kDa zeta-associated protein
-
-
-
-
activin receptor type II
-
activin receptor type IIB
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
-
-
-
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
proto-oncogene tyrosine-protein kinase FYN
-
proto-oncogene tyrosine-protein kinase YES
-
PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
RAF proto-oncogene serine/threonine-protein kinase
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
serine/threonine protein kinase mos
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
tyrosine-protein kinase SRC-1
-
tyrosine-protein kinase SRC-2
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + cdc2
ADP + phosphorylated cdc2
show the reaction diagram
phosphorylated exclusively on Y15
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
fertilized
Manually annotated by BRENDA team
cranial nerve
Manually annotated by BRENDA team
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FAK1_XENLA
1068
0
121156
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
57000
x * 57000, calculation from nucleotide sequence
60000
x * 60000, calculation from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steele, R.E.; Irwin, M.Y.; Knudsen, C.L.; Collett, J.W.; Fero, J.B.
The yes proto-oncogene is present in amphibians and contributes to the maternal RNA pool in the oocyte
Oncogene Res.
4
223-233
1989
Xenopus laevis (P10936)
Manually annotated by BRENDA team
Steele, R.E.; Unger, T.F.; Mardis, M.J.; Fero, J.B.
The two Xenopus laevis SRC genes are co-expressed and each produces functional pp60src
J. Biol. Chem.
264
10649-10653
1989
Xenopus laevis (P13115), Xenopus laevis (P13116)
Manually annotated by BRENDA team
Steele, R.E.
Two divergent cellular src genes are expressed in Xenopus laevis
Nucleic Acids Res.
13
1747-1761
1985
Xenopus laevis (P13116)
Manually annotated by BRENDA team
Steele, R.E.; Deng, J.C.; Ghosn, C.R.; Fero, J.B.
Structure and expression of fyn genes in Xenopus laevis
Oncogene
5
369-376
1990
Xenopus laevis (P13406)
Manually annotated by BRENDA team
Zhang, X.; Wright, C.V.; Hanks, S.K.
Cloning of a Xenopus laevis cDNA encoding focal adhesion kinase (FAK) and expression during early development
Gene
160
219-222
1995
Xenopus laevis (Q91738), Xenopus laevis
Manually annotated by BRENDA team
Hens, M.D.; DeSimone, D.W.
Molecular analysis and developmental expression of the focal adhesion kinase pp125FAK in Xenopus laevis
Dev. Biol.
170
274-288
1995
Xenopus laevis (Q91738), Xenopus laevis
Manually annotated by BRENDA team
Mathews, L.S.; Vale, W.W.; Kintner, C.R.
Cloning of a second type of activin receptor and functional characterization in Xenopus embryos
Science
255
1702-1705
1992
Xenopus laevis (P27041)
Manually annotated by BRENDA team
Kondo, M.; Tashiro, K.; Fujii, G.; Asano, M.; Miyoshi, R.; Yamada, R.; Muramatsu, M.; Shiokawa, K.
Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation
Biochem. Biophys. Res. Commun.
181
684-690
1991
Xenopus laevis (P27039)
Manually annotated by BRENDA team
Freeman, R.S.; Pickham, K.M.; Kanki, J.P.; Lee, B.A.; Pena, S.V.; Donoghue, D.J.
Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes
Proc. Natl. Acad. Sci. USA
86
5805-5809
1989
Xenopus laevis (P12965)
Manually annotated by BRENDA team
Sagata, N.; Oskarsson, M.; Copeland, T.; Brumbaugh, J.; Vande Woude, G.F.
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes
Nature
335
519-525
1988
Xenopus laevis (P12965)
Manually annotated by BRENDA team
Le Guellec, R.; Couturier, A.; Le Guellec, K.; Paris, J.; Le Fur, N.; Philippe, M.
Xenopus c-raf proto-oncogene: cloning and expression during oogenesis and early development
Biol. Cell.
72
39-45
1991
Xenopus laevis (P09560)
Manually annotated by BRENDA team
Le Guellec, R.; Le Guellec, K.; Paris, J.; Philippe, M.
Nucleotide sequence of Xenopus C-raf coding region
Nucleic Acids Res.
16
10357
1988
Xenopus laevis (P09560)
Manually annotated by BRENDA team
Mueller, P.R.; Coleman, T.R.; Dunphy, W.G.
Cell cycle regulation of a Xenopus Wee1-like kinase
Mol. Biol. Cell
6
119-134
1995
Xenopus laevis (P47817)
Manually annotated by BRENDA team