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EC Tree
IUBMB Comments Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
The taxonomic range for the selected organisms is: Sus scrofa The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase,
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serine/threonine-protein kinase transforming protein mos
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70 kDa zeta-associated protein
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A-Raf proto-oncogene serine/threonine-protein kinase
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Agammaglobulinaemia tyrosine kinase
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Amylovoran biosynthesis membrane-associated protein amsA
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B cell progenitor kinase
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B lymphocyte kinase
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B-cell/myeloid kinase
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BCR-ABL tyrosine kinase
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BMP type II receptor
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BMP-2/BMP-4 receptor
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Bone marrow kinase BMX
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Breast tumor kinase
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Bruton's tyrosine kinase
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Calcium-dependent tyrosine kinase
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Cell adhesion kinase beta
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ectoprotein kinase
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Epithelial and endothelial tyrosine kinase
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EPS I polysaccharide export protein epsB
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focal adhesion kinase 1
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gene lck protein kinase
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gene lck tyrosine kinase
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Hematopoietic consensus tyrosine-lacking kinase
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Hemopoietic cell kinase
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IL-2-inducible T-cell kinase
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JAK protein tyrosine kinase
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kinase, protein (phosphorylating tyrosine)
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kinase, protein p56lck (phosphorylating)
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Lck Tyrosine kinase
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Leukocyte janus kinase
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nonreceptor protein tyrosine kinase
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Nuclear tyrosine protein kinase RAK
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p56lck protein kinase
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p56lck protein tyrosine kinase
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p56lck tyrosine kinase
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phosphotyrosyl-protein kinase
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Protein kinase (tyrosine-phosphorylating)
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Protein kinase BATK
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Protein kinase HYL
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Protein kinase Lck
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Protein kinase NTK
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Protein kinase p56-LCK
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Protein kinase p56lck
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Protein p56c-lck kinase
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Protein p56lck tyrosine kinase
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Protein tyrosine kinase
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protein tyrosine kinase 2beta
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Protein tyrosine kinase lck
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Protein tyrosine kinase p56lck
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Protein tyrosine kinase pp56lck
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Protein-tyrosine kinase C-TKL
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Protein-tyrosine kinase CYL
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Related adhesion focal tyrosine kinase
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Resting lymphocyte kinase
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S-domain receptor-like protein kinase
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Spleen tyrosine kinase
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SRC-related intestinal kinase
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Syk-related tyrosine kinase
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T cell-specific protein-tyrosine kinase
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T-cell-specific kinase
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Tyrosine kinase ARG
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Tyrosine kinase lck
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Tyrosine kinase p56lck
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Tyrosine phosphokinase
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Tyrosine protein kinase
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Tyrosine protein kinase p56lck
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Tyrosine-protein kinase brk
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Tyrosine-protein kinase CTK
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Tyrosine-protein kinase Lyk
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tyrosine-protein kinase SYK
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Tyrosine-protein kinase TYRO 10
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Tyrosine-specific protein kinase
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Tyrosylprotein kinase
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v-fps Protein-tyrosine kinase
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YES related kinase
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phospho group transfer
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ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
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114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
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ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
additional information
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the enzyme is involved in regulation of sperm capacitation, signal transduction mechanism, capacitation mechanism, overview
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ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
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ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
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p32 is a sperm protein
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ATP + p32-L-tyrosine
ADP + p32-L-tyrosine phosphate
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additional information
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the enzyme is involved in regulation of sperm capacitation, signal transduction mechanism, capacitation mechanism, overview
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bicarbonate
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required by TK-32 for sperm capacitation activity
Ca2+
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required by TK-32 for tyrosine phosphorylation and sperm capacitation activities
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bistyrphostin
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complete inhibition of TK-32
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SwissProt
brenda
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within ovary, expression is confined to oocytes, remains stable during oocyte maturation
brenda
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brenda
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MOS_PIG
345
0
37941
Swiss-Prot
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32000
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x * 32000, SDS-PAGE
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Taniguchi, T.; Kobayashi, T.; Kondo, J.; Takahashi, K.; Nakamura, H.; Suzuki, J.; Nagai, K.; Yamada, T.; Nakamura, S.; Yamamura, H.
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis
J. Biol. Chem.
266
15790-15796
1991
Sus scrofa (Q00655), Sus scrofa
brenda
Newman, B.; Dai, Y.
Transcription of c-mos protooncogene in the pig involves both tissue-specific promoters and alternative polyadenylation sites
Mol. Reprod. Dev.
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275-288
1996
Sus scrofa (P50118)
brenda
Yasue, H.; Adams, L.; Ozawa, A.; Hanazono, M.; Li, N.; Lin, Z.H.; Kusumoto, H.
Assignment of ARAF1 to porcine chromosome Xp11.2-p13 by fluorescence in situ hybridization
Mamm. Genome
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457-458
1997
Sus scrofa (O19004), Sus scrofa
brenda
Tardif, S.; Dube, C.; Bailey, J.L.
Porcine sperm capacitation and tyrosine kinase activity are dependent on bicarbonate and calcium but protein tyrosine phosphorylation is only associated with calcium
Biol. Reprod.
68
207-213
2003
Sus scrofa
brenda