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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Mus musculus and UniProt Accession P41242
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2.7.10.2 non-specific protein-tyrosine kinaseIUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Word Map
- 2.7.10.2
- leukemia
- imatinib
- lymphocytic
- integrins
-
myelogenous
- metastasis
- t-cells
-
cytogenetic
-
philadelphia
- mapks
- lymphoma
- sh2
- cytoskeleton
- erk
- phosphatidylinositol
- lymphoblastic
- adhesions
-
signal-regulated
-
myeloproliferative
- 3-kinase
- autophosphorylation
- paxillin
- dasatinib
- hematologic
- collagen
-
stats
-
remiss
- arthritis
- fibronectin
- neoplasm
-
relapse
-
tyrosine-phosphorylated
- oncoproteins
-
platelet-derived
- pkc
- phosphotyrosine
-
rheumatoid
-
dominant-negative
- adaptor
- mesylate
-
allogeneic
- factor-beta
-
breakpoints
-
integrin-mediated
- cd4
- crisis
- c-kit
-
activins
- drug development
- synthesis
- medicine
- analysis
- pharmacology
- pdgfr
-
kinase-dependent
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
70 kDa zeta-associated protein
-
-
-
-
Abl
ACTR-IIB
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
Btk
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
JAK2
Janus kinase 2
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
Lyn
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
-
-
-
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
proto-oncogene tyrosine-protein kinase LCK
-
PTK
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Pyk2
Quek1
-
-
-
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
src-kinase
-
-
-
-
SRC-related intestinal kinase
Syk
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
additional information
ACTR-IIB
-
-
-
-
B cell progenitor kinase
-
-
-
-
BMP type II receptor
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
PTK
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
additional information
-
the enzyme belongs to the Src subfamily of the protein tyrosine kinase family
additional information
the enzyme belongs to the Janus family of tyrosine kinases
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
residue W1038 is essential for catalytic activity
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + Cbp
? + ADP
-
murine Csk binding protein, Cbp, amino acids 74-474, substrate used in kinase activity assay
-
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
-
substrate of Akt
-
-
?
ATP + KVEKIGEGTYGVVYK
? + ADP
substrate peptide used in kinase activity assay, derived from p34cdc2
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
-
substrate HCN4, tyrosine 531 is phosphorylated
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
ATP + a protein
ADP + a phosphoprotein
role for this kinase in spermatogenesis
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is a substrate of Src, phosphorylation on Tyr245 and Tyr412
-
-
?
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
-
tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
phosphorylation by Jak2 at tyrosine residues
-
-
?
additional information
?
-
Ntk may play an inhibitory role in the control of T-cell proliferation
-
-
?
additional information
?
-
Ctk is involved in the regulation of neural function and differentiation of male germ cells through interactions with members of the Src family kinases
-
-
?
additional information
?
-
all isoforms of the activin receptor type II bind inhibin A with low affinity
-
-
?
additional information
?
-
the bone morphogenetic protein receptor binds bone morphogenetic protein 2 and bone morphogenetic protein 4
-
-
?
additional information
?
-
the bone morphogenetic protein receptor binds bone morphogenetic protein 2 and bone morphogenetic protein 4
-
-
?
additional information
?
-
-
the bone morphogenetic protein receptor binds bone morphogenetic protein 2 and bone morphogenetic protein 4
-
-
?
additional information
?
-
role for JAK3 in hematopoiesis and T- and B-cell development
-
-
?
additional information
?
-
involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
-
-
?
additional information
?
-
JAK3 kinase is associated with terminal differentiation of hematopoietic cells
-
-
?
additional information
?
-
the enzyme transduces signals initiated by integrin engagement and G protein-coupled receptors. Several splice isoforms of FAK are preferentially expressed in rat brain, some of which have an increased autophosphorylation activity
-
-
?
additional information
?
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
enzyme is involved in pathway for signaling through glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins
-
-
?
additional information
?
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
may interact with the intracellular domain of cell surface receptors
-
-
?
additional information
?
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
-
-
?
additional information
?
-
perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Syk-deficient radiation chimaeras fail to accumulate mature B cells, Syk-deficient mice show impaired development of thymocytes using the V gamma 3 variable region gene, Syk is not required for signalling through the IL-2 and G-CSF receptors
-
-
?
additional information
?
-
Rlk has potential functions in intrathymic T cell development and mature T cell signaling
-
-
?
additional information
?
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
activating motif occurs in four discrete steps: binding of p59fyn, phosphorylation of the motif, binding of ZAP-70, and activation of ZAP-70 kinase activity
-
-
?
additional information
?
-
could be responsible for the tyrosine phosphorylation observed in a murine thymic medullary epithelial cell line E-5 following complex formation with thymocytes
-
-
?
additional information
?
-
type II receptor isoforma exist which play preferential binding to TGF-beta2 and have their own defined role in debvelopment
-
-
?
additional information
?
-
mRIP3 uses a novel mechanism to induce death
-
-
?
additional information
?
-
in a cell cycle the wee1 kinase is phosphorylated at M-phase, phosphorylation occurs in the N-terminal domain resulting in inactivation of the kinase activity. The N-terminal domain, or the entire molecule is extensively phosphorylated by cdc2-cyclin B kinase
-
-
?
additional information
?
-
-
CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview
-
-
?
additional information
?
-
-
Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis
-
-
?
additional information
?
-
-
Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival
-
-
?
additional information
?
-
-
protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview
-
-
?
additional information
?
-
-
Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview
-
-
?
additional information
?
-
-
the enzyme plays an important role in the self-renewal and as comitogen in the movement of stem cells out of the haematopoietic stem cell pool into the progeny pool, regulation of bone marrow cell migration
-
-
?
additional information
?
-
-
the BCR/ABL kinase performs tyrosine autophosphorylation, mechanism
-
-
?
additional information
?
-
-
Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview
-
-
?
additional information
?
-
-
Csk is essential for mouse embryonic development, Csk plays a role in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration, overview, modeling of Csk regulation of focal adhesion turnover
-
-
?
additional information
?
-
-
enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo
-
-
?
additional information
?
-
-
Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
-
-
?
additional information
?
-
-
PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview
-
-
?
additional information
?
-
-
spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1, neutrophil activation pathways, overview
-
-
?
additional information
?
-
-
Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation
-
-
?
additional information
?
-
-
Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview
-
-
?
additional information
?
-
-
the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity
-
-
?
additional information
?
-
the enzyme is involved in cytokine signaling
-
-
?
additional information
?
-
-
tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling
-
-
?
additional information
?
-
-
Abl does not mediate tyrosine phosphorylation of Stat3 and Shc, two important regulators of Src oncogenic activity
-
-
?
additional information
?
-
-
Fak binds interaction partners, e.g. paxillin, talin, and p190RhoGEF, at the FAT domain, i.e. the focal adhesion targeting domain, at the C-terminal domain modulaing the Fak activity, overview
-
-
?
additional information
?
-
-
receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another
-
-
?
additional information
?
-
-
Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
role for this kinase in spermatogenesis
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview
-
-
?
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
-
tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview
-
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
-
substrate of Akt
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
additional information
?
-
Ntk may play an inhibitory role in the control of T-cell proliferation
-
-
?
additional information
?
-
Ctk is involved in the regulation of neural function and differentiation of male germ cells through interactions with members of the Src family kinases
-
-
?
additional information
?
-
role for JAK3 in hematopoiesis and T- and B-cell development
-
-
?
additional information
?
-
involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
-
-
?
additional information
?
-
JAK3 kinase is associated with terminal differentiation of hematopoietic cells
-
-
?
additional information
?
-
the enzyme transduces signals initiated by integrin engagement and G protein-coupled receptors. Several splice isoforms of FAK are preferentially expressed in rat brain, some of which have an increased autophosphorylation activity
-
-
?
additional information
?
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
enzyme is involved in pathway for signaling through glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins
-
-
?
additional information
?
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
may interact with the intracellular domain of cell surface receptors
-
-
?
additional information
?
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
-
-
?
additional information
?
-
perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Syk-deficient radiation chimaeras fail to accumulate mature B cells, Syk-deficient mice show impaired development of thymocytes using the V gamma 3 variable region gene, Syk is not required for signalling through the IL-2 and G-CSF receptors
-
-
?
additional information
?
-
Rlk has potential functions in intrathymic T cell development and mature T cell signaling
-
-
?
additional information
?
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
activating motif occurs in four discrete steps: binding of p59fyn, phosphorylation of the motif, binding of ZAP-70, and activation of ZAP-70 kinase activity
-
-
?
additional information
?
-
could be responsible for the tyrosine phosphorylation observed in a murine thymic medullary epithelial cell line E-5 following complex formation with thymocytes
-
-
?
additional information
?
-
type II receptor isoforma exist which play preferential binding to TGF-beta2 and have their own defined role in debvelopment
-
-
?
additional information
?
-
mRIP3 uses a novel mechanism to induce death
-
-
?
additional information
?
-
in a cell cycle the wee1 kinase is phosphorylated at M-phase, phosphorylation occurs in the N-terminal domain resulting in inactivation of the kinase activity. The N-terminal domain, or the entire molecule is extensively phosphorylated by cdc2-cyclin B kinase
-
-
?
additional information
?
-
-
CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview
-
-
?
additional information
?
-
-
Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis
-
-
?
additional information
?
-
-
Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival
-
-
?
additional information
?
-
-
protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview
-
-
?
additional information
?
-
-
Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview
-
-
?
additional information
?
-
-
the enzyme plays an important role in the self-renewal and as comitogen in the movement of stem cells out of the haematopoietic stem cell pool into the progeny pool, regulation of bone marrow cell migration
-
-
?
additional information
?
-
-
Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview
-
-
?
additional information
?
-
-
Csk is essential for mouse embryonic development, Csk plays a role in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration, overview, modeling of Csk regulation of focal adhesion turnover
-
-
?
additional information
?
-
-
enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo
-
-
?
additional information
?
-
-
Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
-
-
?
additional information
?
-
-
PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview
-
-
?
additional information
?
-
-
spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1, neutrophil activation pathways, overview
-
-
?
additional information
?
-
-
Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation
-
-
?
additional information
?
-
-
Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview
-
-
?
additional information
?
-
-
the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity
-
-
?
additional information
?
-
the enzyme is involved in cytokine signaling
-
-
?
additional information
?
-
-
tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
-
indirect pharmacological inhibitor
4-(2-fluoro-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
-
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
-
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(isopropylamino)-9H-carbazole-1-carboxamide
-
4-(3-(5-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
4-(3-(5-fluoropicolinamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
-
4-(3-(6-fluoro-1-oxoisoindolin-2-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
4-(3-(7-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
4-(3-(8-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
-
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-9H-carbazole-1-carboxamide
-
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
-
7-(2-hydroxypropan-2-yl)-4-(3-(4-oxoquinazolin-3(4H)-yl)-phenyl)-9H-carbazole-1-carboxamide
-
7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide
BMS-935177
7-(hydroxymethyl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-9H-carbazole-1-carboxamide
-
curcumin
-
downregulates and inhibits tyrosine kinase Syk, which leads to inhibition of Akt, in lymphoma cells, curcumin causes growth inhibition of B lymphoma, mechanism, overview
Src kinase inhibitor-1
-
i.e. SKI-1, a 4-anilinoquinazoline, moderate inhibition in vitro and vivo
-
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
-
PP2, AG-1897
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
-
i.e. pp2, broad spectrum SFK inhibitor, competitive to ATP, in vitro and in vivo
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
-
i.e. pp2, inhibits Src family PTKs
dasatinib
-
Jak2 inhibitor, at high doses (0.001 mM), dasatinib can inhibit Jak2 activity in vitro
imatinib
-
inhibits ABL1autophosphorylation as well as substrate phosphorylation
LFM-A13
-
significantly impairs CXCL12-induced mouse B cell chemotaxis, and blocks Akt activation, homing of transferred B cells to peripheral lymph nodes is impaired, LFM-A13 significantly reduces the CXCL12-induced increases in Ca2+, overview
additional information
-
phosphorylation of Tyr508 in Lyn inhibits activity of the enzyme
-
additional information
-
ABL1 is autoinhibited in an intramolecular fashion that is similar to SRC kinases, where the SH3 domain is engaged with a single proline residue in the spacer region between the SRC homology 2 and tyrosine kinase domains
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
CX3CL1
-
i.e. fractalkine, only member of the delta subclass of chemokines, induces Syk activity in cytoskeletal remodeling
-
non-specific BRM sheep erythrocyte
-
BRM is biological response modifier, treatment leads to a slight enzyme activation in leukemic bone marrow cells
-
Reelin
-
extracellular, stimulates disabled-1 adaptor protein Dab1 tyrosine phosphorylation by Src family PTKs, downregulates Dab1 expression in vivo
-
tyrosine growth factor
-
the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors
-
additional information
Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor beta-chain, but does not require the acidic domain that is required for association and activation of Src family kinases
-
additional information
-
a treatment of leukemic bone marrow cells with a mixture of interleukin-2, interferon-gamma, and non-specific BRM sheep erythrocytes leads to an increase in enzyme activity
-
additional information
-
the leukemia inhibitory factor LIF and other growth factors are linked to Src family kinase activation
-
additional information
-
brain-derived neurotrophic factor BDNF induces the association and colocalization of TrkB with the lipid raft-resident protein Fyn, in situ study
-
additional information
-
FAK and PYK2 are activated in response to motogenic and mitogenic factors by phosphorylation and autophosphorylation
-
additional information
-
PYK2 is phosphorylated for activation involving the vascular endothelial growth factor, overview
-
additional information
-
Btk activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate
-
additional information
Btk activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate
-
additional information
nerve injury induces the activation of Src family kinases, Lyn is the predominant kinase
-
additional information
-
phosphorylation of Tyr397 in Lyn results in activation of the enzyme
-
additional information
-
Tec activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate
-
additional information
Tec activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000004
4-(2-fluoro-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000005
4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000005
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000011
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(isopropylamino)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000005
4-(3-(5-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000009
4-(3-(5-fluoropicolinamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000002
4-(3-(6-fluoro-1-oxoisoindolin-2-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000007
4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000002
4-(3-(7-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000002
4-(3-(8-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000009
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
Mus musculus
-
substrate Csk binding protein, Cbp
0.000003
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000005
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000005
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000044
7-(2-hydroxypropan-2-yl)-4-(3-(4-oxoquinazolin-3(4H)-yl)-phenyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000003
7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
0.000003
7-(hydroxymethyl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
at pH 7.4 and 22°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
cell proliferation and migration activities in wild-type and enzyme-deficient endothelial fibroblasts, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
upregulated expression of syk is observed in aggressive, metastasizing mammary gland tumours but not in well differentiated, non-metastasizing tumors
expressed only in epithelial tissues, including the skin and lining of the alimentary canal
-
peripheral, in bone marrow and spleen, Fps/Fes tyrosine kinase expression in early erythroid progenitors/blasts and in mature red cells
-
ES cell D3 line, embryonic stem cell, expression of 7 different Src family kinases, 3 are involved in differentiation to embryoid bodies
retinal ganglion cell layer and the inner part of the inner nuclear layer. During retinal development, JAK1 protein is first detected in retinal ganglion cells and in their axons as early as embryonic day 14. Expression of JAK1 protein in amacrine cells and horizontal cells occurrs only postnatally
additional information
-
Ly-10 DLBCL cells or WEHI-231 cells, Akt and Syk, the latter is constitutively activated in primary tumor cells
several splice isoforms of FAK are preferentially expressed in rat brain
enzyme is expressed constitutively at a low level in normal T-cells and at an elevated level in the LSTRA and Thy19 Moloney murine leukemia virus-induced thymoma cell lines
-
enzyme is expressed constitutively at a low level in normal T-cells and at an elevated level in the LSTRA and Thy19 Moloney murine leukemia virus-induced thymoma cell lines
src-related gene is expressed in normal macrophages and in cell lines representing both the myeloid and lymphoid B-cell lineages
expressed in all stages of the B lineage and in myeloid cells
sik mRNA is first detected at day 15.5 of gestation in the embryo, where it is expressed in the newly forming granular layer of the skin
JAK3 is expressed at very low levels in immature hematopoietic cells, expression is dramatically up-regulated during terminal differentiation of these cells
fetal thymus as early as day 13 of embryonic development as well as in adult thymus and mature resting peripheral T cells
additional information
tissue expression pattern of the two predominant transcripts, TecIII and TecIV: both TecIII and TecIV are expressed as early as embryonic day 10.5 in mouse development, as well as in adult and embryonic organs. The ratio of TecIV to TecIII expression is markedly reduced in adult liver and kidney tissues and d16 embryonic limb
additional information
-
tissue expression pattern of the two predominant transcripts, TecIII and TecIV: both TecIII and TecIV are expressed as early as embryonic day 10.5 in mouse development, as well as in adult and embryonic organs. The ratio of TecIV to TecIII expression is markedly reduced in adult liver and kidney tissues and d16 embryonic limb
additional information
type II receptor expression is not detected in the central nervous system and developing cartilage
additional information
-
ubiquitous expression of Src, Fyn, Yes, and Yrk, while Blk, Fgr, Hck, Lck, and Lyn are expressed in more restricted patterns
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment
-
ABL1 is translocated into the nucleus where its activity contributes to induction of apoptosis and inhibition of cell growth
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
-
deficiency of Jak3 or Tyk2 results in defined clinical disorders, a striking phenotype associated with inactivating Jak3 mutations is severe combined immunodeficiency syndrome, whereas mutation of Tyk2 results in autosomal recessive hyperimmunoglobulin E syndrome, complete deletion of Jak1 or Jak2 in the mouse are not compatible with life and do not have counterparts in human disease. Activating mutations of each of the Jaks are found in association with malignant transformation, the most common being gain-of-function mutations of Jak2 in polycythemia vera and other myeloproliferative disorders. Jak1 knockout mice have major deficits in lymphopoiesis and a failure to respond to signals from class II cytokine receptors, gammac cytokine receptors, and cytokine receptors that contain the gp130 subunit. Jak2 deficiency is lethal.
malfunction
-
mutations of JAK3 may be a cause of severe combined immunodeficiency, JAK3 knockout mice have a profound reduction in thymic progenitor cells and reduced ability to reconstitute T cell development, in the periphery, CD8+ T and NK cells are severely reduced. JAK3- (and gamma chain) deficient mice also have severely defective B cell development, deficiency of JAK1 and JAK2 is lethal
malfunction
-
only 75% of ABL1 knockout mice survive the first week,33 the remaining animals show severe defects in spermatogenesis, thymic and splenic atrophy, susceptibility to infections and reductions of T- and B-cell lymphocytes and their early precursors in lymphoid organs
malfunction
enzyme-deficiency leads to a reduction in mature peripheral B cells. Enzyme-deficient mice fail to respond to immunization with type 2 thymus-independent antigens, and accordingly, peripheral B cells from these animals are unresponsive to B cell receptor crosslinking
physiological function
-
ABL1 binds to the actin cytoskeleton and is involved in cytoskeletal organization, non-erythroid myelopoiesis and regulation of small GTPases, in response to genotoxic stress such as DNA damage or the increase of reactive oxygen species, ABL1 is translocated into the nucleus where its activity contributes to induction of apoptosis and inhibition of cell growth
physiological function
-
JAK3 associates with the common gamma chain cytokine receptor, Tyk2 is involved in signaling by type I interferons, interleukin-12 and interleukin-23
physiological function
murine Btk-/- natural killer cells have decreased innate immune responses to the toll-like receptor TLR3 ligand, with reduced expressions of IFN-gamma, perforin, and granzyme-B and decreased cytotoxic activity. Isoform Btk promotes TLR3-triggered natural killer cell activation mainly by activating the NF-kappaB pathway. Poly(I:C)-induced natural killer cell-mediated acute hepatitis is attenuated in Btk-/- mice or the mice with in vivo administration of Btk inhibitor. Correspondingly, liver damage is aggravated in Btk-/- mice after the adoptive transfer of Btk-/- natural killer cells
physiological function
-
specific pharmacological inhibition and genetic silencing indicate the involvement of isoform Lck in the regulation of neuritic outgrowth. Specific Lck inhibition also selectively impairs the long-term hippocampal synaptic plasticity without affecting spontaneous excitatory synaptic transmission or short-term synaptic potentiation and significantly alters hippocampus-dependent spatial learning and memory in vivo
physiological function
-
the enzyme influences neuronal differentiation via a chronic regulation of Na+ channel functionality. The tonic enzyme activity is also critical for normal development of functional Na+ channels and neuronal differentiation or maturation of embryonic stem cells
physiological function
the enzyme is essential for B cell activation and differentiation
physiological function
the enzyme (Pyk2) promotes the turnover of monocytes at steady state
physiological function
the enzyme (SYK) drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis. SYK centrally mediates signaling upstream of caspase-1 and caspase-8 activation and principally up-regulates NF-kappaB and IL-1beta signaling in Pstpip2(cmo) mice, thereby inducing cmo
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). MATK_MOUSE
505
0
56056
Swiss-Prot
Mitochondrion (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
53000
alternative splicing variant, identified by SDS-PAGE and Western blot analysis
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
domain structure including catalytic and ligand binding domains, and an activation loop spanning from Asp994 to Glu1024, the domains are termed JH1 to JH7, overview
additional information
molecular modeling of the active site of wild-type and mutant Jak2, overview
additional information
-
molecular modeling of the active site of wild-type and mutant Jak2, overview
additional information
-
the NH2-terminal unique domain, the Src homology SH 4 region, is required for membrane attachment, SH4 is followed by the regulatory SH3 and SH2 domains, which are highly conserved and bind proline-rich and phosphotyrosyl regions, respectively
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
side-chain modification
additional information
phosphoprotein
IL-3 stimulation results in the rapid and specific tyrosine phosphorylation of Jak2
phosphoprotein
-
phosphorylation of the activation loop, especially at Tyr1007, is essential for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation
phosphoprotein
-
PYK2 is phosphorylated for activation involving the vascular endothelial growth factor, while tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway overview
phosphoprotein
-
the enzyme is activated and translocated upon phosphorylation at tyrosines, and also performs autophosphorylation
phosphoprotein
the enzyme is activated via phosphorylation at the activation loop, also by autophosphorylation
phosphoprotein
full activation requires autophosphorylation at a tyrosine residue located in the kinase domain
phosphoprotein
phosphorylation by other kinases and autophosphorylation at Tyr223 of Btk
phosphoprotein
-
normal activation of the ABL1 proteins requires phosphorylation
phosphoprotein
-
Y785 and Y813 in JAK3 and JAK2 respectively are prominent sites of autophosphorylation
side-chain modification
palmitoylation of an amino-terminal cysteine motif of protein tyrosine kinase mediates interaction with glycosyl-phosphatidylinositol-anchored proteins
side-chain modification
palmitoylation may play an important role in the localization and function of Src family protein tyrosine kinases
additional information
lacks the consensus tyrosine phosphorylation and myristoylation sites
additional information
TGF-beta RII gene generates multiple isoforms, possibly by alternative splicing
additional information
-
TGF-beta RII gene generates multiple isoforms, possibly by alternative splicing
additional information
two of the ActR-IIB isoforms have higher affinity for activin A than the previously cloned activin receptor and differ from each other by the inclusion of an alternatively spliced segment in the cytoplasmic juxtamembrane region. A second alternative splicing event generates two additional receptor isoforms that lack a proline cluster in the external juxtamembrane region and have lower affinity for activin A
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of the extracellular ligand-binding domain of the type II activin receptor
determination of the three-dimensional solution structure of the SH2 domain of blk kinase by nuclear magnetic resonance NMR spectroscopy
hanging drop vapor diffusion method, using 31% (w/v) methyl ether PEG 5000, 1% (w/v) PEG 8000, 0.2 M Tris-HCl, pH 8.5
high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2
the crystal structures of the kinase domain of Lyn are determined in complex with three different inhibitors, AMP-PNP, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine and dasatinib, as well as the non-liganded form of the enzyme, at 2.5 to 2.7 A resolution
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K273R
mutant protein is unable to transfer the gamma-phosphate of ATP but able to bind 8-azido-ATP with an efficiency similar to that of wild-type pp56lck
V617F
W1038G/E1046A
site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview
W1038G/E1046R
site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview
additional information
V617F
the mutation modulates Skp2 gene expression through the STAT transcription factors and is regarded as the major cause of myeloproliferative disorders
V617F
-
the mutation within the JH2 pseudokinase domain of Jak2 is present in almost all patients with polycythemia vera, as well as high percentages also in patients with essential thrombocythemia, and idiopathic myelofibrosis
additional information
generation of mutants of the protein-tyrosine kinase pp56lck that have single amino acid substitutions within the area surrounding the conserved residue Lys-273 in subdomain II. When compared with wild-type pp56lck, these mutants display profound reductions in their phosphotransfer efficiencies and small differences in their affinities for ATP
additional information
temperature-sensitive mutants of the lck tyrosine protein kinase
additional information
-
a gain-of-function mutant fps/fes transgene, i.e. fpsMF, encoding an activated Fps/Fes variant, i.e. MFps, is constructed, tissue-specific expression in mice, mutant mice show reduced peripheral erythrocytes and accumulation of immature erythroid precursors displaying increased survival, activation of the mutant enzyme by erythropoietin and stem cell factor leads to increased STAT5A/B activation and reduced ERK1/2 phosphorylation
additional information
-
homozygous knock-out mice with mutational inactivated Fps and Fer protein-tyrosine kinases are viable and shows reduced fertility, and deregulated hematopoiesis with elevated neutrophils, erythrocytes, and platelets, but reduced overall bone marrow cellularity, overview
additional information
-
Btk-deficient bone marrow-derived macrophages secrete decreased levels of IL-10 in response to multiple TLR ligands, compared with wild-type cells, overview
additional information
-
construction of Fyn brain knockout mice, brain-derived neurotrophic factor BDNF-induced TrkB, Akt, and PLCgamma phosphorylation is affected in Fyn knock-out neurons, phenotype, overview
additional information
-
Csk is essential for mouse embryonic development, Csk knock-out mice dye at early stages of embryogenesis around embryonic day 10, Csk deficiency in mouse embryonic fibroblast cells blocks cell migration induced by lysophosphatidic acid through G protein-coupled receptors, by platelet-derived growth factor and epidermal growth factor through receptor tyrosine kinases, and by serum, molecular mechanism, phenotype, overview
additional information
-
downregulation of Abl expression by siRNA expression in NIH 3T3 cells reduces Src-mT-induced foci
additional information
-
E-selectin-induced alpha(L)beta(2) integrin-mediated rolling is abolished in syk-/- mice bone marrow, neutrophil recruitment in a thioglycollate-induced peritonitis model is almost completely inhibited, overview
additional information
-
knockout fak-/- mice show a heavily compromised phenotype with complete absence of the cardiovascular system and early embryonic lethality, enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo
additional information
-
PYK2-deficient phenotype with reduced vasodilatation, response to NO, and neovessel formation, detailed overview
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
application of the polymerase chain reaction to cloning
expression in COS cells
expression of SFKs Hck, Fyn, Lck, and Yes in human 293T cells, expression of N-terminally His-tagged Hck in Spodoptera frugiperda Sf9 cells via baculovirus infection system
-
genetic analysis of mutations causing cell cycle deregulation, e.g. in mice lacking cyclin-D2, heterozygous D2+/- mice are resistant to BCR/ABL-induced proliferation, overview
-
Jak2, DNA and amino acid sequence determination and analysis, oc-expression of wild-type Jak2 with increasing amounts of mutant W1038G/E1024A or mutant W1038G/E1024R, the latter is more potent in reducing wild-type enzyme actiivty in a dominant-negative way, overview
lskT gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
retroviral expression in 293T cells prior to infection of RAW cells for stable Syk expression
-
testis-specific c-abl mRNAs arise as a result of 3' truncation. The v-abl gene has arisen from its cellular homologue as a result of an extensive deletional/mutational process
the murine Lyn kinase domain, amino acids 239-512, is subcloned into the baculovirus expression vector pFastBacHTA generating a His6-tagged fusion resulting in a 5 amino acid N-terminal extension to the Lyn kinase domain after tobacco etch virus cleavage
-
the retroviral vectors pMX-Btk-IRES-GFP, pMX-Btk(R28C)-IRES-GFP and pMX-Btk(R525Q)-IRES-GFP are constructed
two isoforms of murine hck, generated by utilization of alternative translational initiation codons
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
isoform Btk expression is up-regulated during maturation and activation of mouse natural killer cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
pharmacology
-
the enzyme is a pharmaceutical target for inhibitors in therapy of acute inflammatory responses, e.g. acute lung injury, ischemic brain injury, brain injury, spinal cord compression, stroke, and myocardial infarction, detailed overview
medicine
-
Btk plays a critical role in osteoclast multinucleation by modulating the activity of the nuclear factor of activated T cells c1, NFATc1
medicine
Lyn is a key kinase in the molecular machineries mediating the P2X4R upregulation in microglia, and thereby, in neuropathic pain
medicine
-
Lyn kinase inhibitors are becoming an increasingly important class of chemotherapeutic agents
medicine
Syk may be a potential target for the development of potent anti-inflammatory drugs
medicine
Tec kinase is a potential therapeutic target for bone diseases
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ORGANISM (UNIPROT)
PUBMED ID
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Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing
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Mus musculus (P00520), Mus musculus
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Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart
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237
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1987
Mus musculus (P05480)
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Thymic tumorigenesis induced by overexpression of p56lck
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88
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Mus musculus (P06240), Mus musculus
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Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck
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350
62-66
1991
Mus musculus (P06240), Mus musculus
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Avian reovirus mRNAs are nonfunctional in infected mouse cells: translational basis for virus host-range restriction
Proc. Natl. Acad. Sci. USA
85
4257-4261
1988
Mus musculus (P06240)
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The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP
Proc. Natl. Acad. Sci. USA
90
442-446
1993
Mus musculus (P06240)
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Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line
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8
3058-3064
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Mus musculus (P06240), Mus musculus
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Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase
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66
7406-7413
1992
Mus musculus (P06240)
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303
749-753
1994
Mus musculus (P06240)
Marth, J.D.; Peet, R.; Krebs, E.G.; Perlmutter, R.M.
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
Cell
43
393-404
1985
Mus musculus (P06240), Mus musculus
Shenoy-Scaria, A.M.; Gauen, L.K.; Kwong, J.; Shaw, A.S.; Lublin, D.M.
Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins
Mol. Cell. Biol.
13
6385-6392
1993
Mus musculus (P06240)
Voronova, A.F.; Adler, H.T.; Sefton, B.M.
Two lck transcripts containing different 5' untranslated regions are present in T cells
Mol. Cell. Biol.
7
4407-4413
1987
Mus musculus (P06240), Mus musculus
Voronova, A.F.; Sefton, B.M.
Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion
Nature
319
682-685
1986
Mus musculus (P06240), Mus musculus
Holtzman, D.A.; Cook, W.D.; Dunn, A.R.
Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells
Proc. Natl. Acad. Sci. USA
84
8325-8329
1987
Mus musculus (P08103)
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Nucleotide sequence of the mouse hck gene
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15
9600
1987
Mus musculus (P08103)
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Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization
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11
4363-4370
1991
Mus musculus (P08103), Homo sapiens (P08631)
King, F.J.; Cole, M.D.
Molecular cloning and sequencing of the murine c-fgr gene
Oncogene
5
337-344
1990
Mus musculus (P14234)
Yi, T.L.; Willman, C.L.
Cloning of the murine c-fgr proto-oncogene cDNA and induction of c-fgr expression by proliferation and activation factors in normal bone marrow-derived monocytic cells
Oncogene
4
1081-1087
1989
Mus musculus (P14234), Mus musculus
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The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family
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85
67-74
1989
Mus musculus (P16879), Mus musculus (P24604), Mus musculus (P25911), Mus musculus (P52332), Mus musculus (Q62120)
Dymecki, S.M.; Niederhuber, J.E.; Desiderio, S.V.
Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells
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247
332-336
1990
Mus musculus (P16277), Mus musculus
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The three-dimensional solution structure of the SH2 domain from p55blk kinase
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35
6201-6211
1996
Mus musculus (P16277)
Wilks, A.F.; Kurban, R.R.
Isolation and structural analysis of murine c-fes cDNA clones
Oncogene
3
289-294
1988
Mus musculus (P16879), Mus musculus
Mano, H.; Ishikawa, F.; Nishida, J.; Hirai, H.; Takaku, F.
A novel protein-tyrosine kinase, tec, is preferentially expressed in liver
Oncogene
5
1781-1786
1990
Mus musculus (P24604), Mus musculus
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Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit
Oncogene
8
417-424
1993
Mus musculus (P24604), Mus musculus
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Splice variants of the mouse Tec gene are differentially expressed in vivo
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84
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Mus musculus (P24604), Mus musculus
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Alternatively spliced murine lyn mRNAs encode distinct proteins
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11
3399-3406
1991
Mus musculus (P25911)
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Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus
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11
2391-2398
1991
Mus musculus (P25911), Mus musculus
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6
334-338
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Mus musculus (P35991)
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261
358-361
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Mus musculus (P35991), Mus musculus
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153
5607-5617
1994
Mus musculus (P35991), Mus musculus
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Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
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72
279-290
1993
Mus musculus (P35991)
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Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells
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192
231-240
1993
Mus musculus (P35991), Mus musculus (Q03526)
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An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
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7
2499-2506
1992
Mus musculus (P41241)
Klages, S.; Adam, D.; Class, K.; Fargnoli, J.; Bolen, J.B.; Penhallow, R.C.
Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family
Proc. Natl. Acad. Sci. USA
91
2597-2601
1994
Mus musculus (P41241), Mus musculus (P41242), Mus musculus
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Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes
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91
4975-4979
1994
Mus musculus (P41242)
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Presence of alternative 5' untranslated sequences and identification of cells expressing ctk transcripts in the brain and testis
Oncogene
10
945-952
1995
Mus musculus (P41242)
Haire, R.N.; Litman, G.W.
The murine form of TXK, a novel TEC kinase expressed in thymus maps to chromosome 5
Mamm. Genome
6
476-480
1995
Mus musculus (P42682), Mus musculus
Hu, Q.; Davidson, D.; Schwartzberg, P.L.; Macchiarini, F.; Lenardo, M.J.; Bluestone, J.A.; Matis, L.A.
Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage
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270
1928-1934
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Mus musculus (P42682)
Gauen, L.K.; Zhu, Y.; Letourneur, F.; Hu, Q.; Bolen, J.B.; Matis, L.A.; Klausner, R.D.; Shaw, A.S.
Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif
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14
3729-3741
1994
Mus musculus (P43404)
Fluck, M.; Zurcher, G.; Andres, A.C.; Ziemiecki, A.
Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein
Biochem. Biophys. Res. Commun.
213
273-281
1995
Mus musculus (P48025)
Turner, M.; Mee, P.J.; Costello, P.S.; Williams, O.; Price, A.A.; Duddy, L.P.; Furlong, M.T.; Geahlen, R.L.; Tybulewicz, V.L.
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
Nature
378
298-302
1995
Mus musculus (P48025)
Wilks, A.F.
Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction
Proc. Natl. Acad. Sci. USA
86
1603-1607
1989
Mus musculus (P52332), Mus musculus (Q62120)
Yang, X.; Chung, D.; Cepko, C.L.
Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system
J. Neurosci.
13
3006-3017
1993
Mus musculus (P52332), Mus musculus
Hebert, B.; Bergeron, J.; Tijssen, P.; Potworowski, E.F.
Protein tyrosine kinases transcribed in a murine thymic medullary epithelial cell line
Gene
143
257-260
1994
Mus musculus (Q04736)
Klages, S.; Adam, D.; Eiseman, E.; Fargnoli, J.; Dymecki, S.M.; Desiderio, S.V.; Bolen, J.B.
Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase
Oncogene
8
713-719
1993
Mus musculus (Q04736), Mus musculus
Silvennoinen, O.; Witthuhn, B.A.; Quelle, F.W.; Cleveland, J.L.; Yi, T.; Ihle, J.N.
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
Proc. Natl. Acad. Sci. USA
90
8429-8433
1993
Mus musculus (Q62120), Mus musculus
Gurniak, C.B.; Berg, L.J.
Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells
Blood
87
3151-3160
1996
Mus musculus (Q62137)
Rane, S.G.; Reddy, E.P.
JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells
Oncogene
9
2415-2423
1994
Mus musculus (Q62137)
Witthuhn, B.A.; Silvennoinen, O.; Miura, O.; Lai, K.S.; Cwik, C.; Liu, E.T.; Ihle, J.N.
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
Nature
370
153-157
1994
Mus musculus (Q62137)
Kawachi, Y.; Nakauchi, H.; Otsuka, F.
Isolation of a cDNA encoding a tyrosine kinase expressed in murine skin
Exp. Dermatol.
6
140-146
1997
Mus musculus (Q62270), Mus musculus
Kohmura, N.; Yagi, T.; Tomooka, Y.; Oyanagi, M.; Kominami, R.; Takeda, N.; Chiba, J.; Ikawa, Y.; Aizawa, S.
A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption
Mol. Cell. Biol.
14
6915-6925
1994
Mus musculus (Q62270)
Vasioukhin, V.; Serfas, M.S.; Siyanova, E.Y.; Polonskaia, M.; Costigan, V.J.; Liu, B.; Thomason, A.; Tyner, A.L.
A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract
Oncogene
10
349-357
1995
Mus musculus (Q64434), Mus musculus
Benzing, T.; Gerke, P.; Hopker, K.; Hildebrandt, F.; Kim, E.; Walz, G.
Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2
Proc. Natl. Acad. Sci. USA
98
9784-9789
2001
Mus musculus (Q9QVP9)
Burgaya, F.; Toutant, M.; Studler, J.M.; Costa, A.; Le Bert, M.; Gelman, M.; Girault, J.A.
Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity
J. Biol. Chem.
272
28720-28725
1997
Mus musculus (P34152)
Avraham, S.; London, R.; Fu, Y.; Ota, S.; Hiregowdara, D.; Li, J.; Jiang, S.; Pasztor, L.M.; White, R.A.; Groopman, J.E.; et al.
Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain
J. Biol. Chem.
270
27742-27751
1995
Mus musculus (Q9QVP9), Mus musculus
Hanks, S.K.; Calab, M.B.; Harper, M.C.; Patel, S.K.
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin
Proc. Natl. Acad. Sci. USA
89
8487-8491
1992
Mus musculus (P34152), Mus musculus
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (P04627), Mus musculus (P47810)
Greenwald, J.; Fischer, W.H.; Vale, W.W.; Choe, S.
Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase
Nat. Struct. Biol.
6
18-22
1999
Mus musculus (P27038)
Beppu, H.; Minowa, O.; Miyazono, K.; Kawabata, M.
cDNA cloning and genomic organization of the mouse BMP type II receptor
Biochem. Biophys. Res. Commun.
235
499-504
1997
Mus musculus (O35607), Mus musculus
Wu, X.; Robinson, C.E.; Fong, H.W.; Crabtree, J.S.; Rodriguez, B.R.; Roe, B.A.; Gimble, J.M.
Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog
Biochem. Biophys. Res. Commun.
216
78-83
1995
Mus musculus (Q61288)
Dewulf, N.; Verschueren, K.; Lonnoy, O.; Moren, A.; Grimsby, S.; Vande Spiegle, K.; Miyazono, K.; Huylebroeck, D.; Ten Dijke, P.
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
Endocrinology
136
2652-2663
1995
Mus musculus (P36895), Mus musculus (Q61288)
Tomoda, T.; Kudoh, T.; Noma, T.; Nakazawa, A.; Muramatsu, M.; Arai, K.
Molecular cloning of a mouse counterpart for human TGF-beta type I receptor
Biochem. Biophys. Res. Commun.
198
1054-1062
1994
Mus musculus (Q64729)
ten Dijke, P.; Yamashita, H.; Ichijo, H.; Franzen, P.; Laiho, M.; Miyazono, K.; Heldin, C.H.
Characterization of type I receptors for transforming growth factor-beta and activin
Science
264
101-104
1994
Mus musculus (P36898)
Suzuki, A.; Shioda, N.; Maeda, T.; Tada, M.; Ueno, N.
Cloning of an isoform of mouse TGF-beta type II receptor gene
FEBS Lett.
355
19-22
1994
Mus musculus (Q62312), Mus musculus
Suzuki, A.; Thies, R.S.; Yamaji, N.; Song, J.J.; Wozney, J.M.; Murakami, K.; Ueno, N.
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
Proc. Natl. Acad. Sci. USA
91
10255-10259
1994
Mus musculus (P36895)
Suzuki, A.; Shioda, N.; Maeda, T.; Tada, M.; Ueno, N.
A mouse TGF-beta type I receptor that requires type II receptor for ligand binding
Biochem. Biophys. Res. Commun.
198
1063-1069
1994
Mus musculus (Q64729), Mus musculus
Lawler, S.; Candia, A.F.; Ebner, R.; Shum, L.; Lopez, A.R.; Moses, H.L.; Wright, C.V.; Derynck, R.
The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1
Development
120
165-175
1994
Mus musculus (Q62312)
Koenig, B.B.; Cook, J.S.; Wolsing, D.H.; Ting, J.; Tiesman, J.P.; Correa, P.E.; Olson, C.A.; Pecquet, A.L.; Ventura, F.; Grant, R.A.; et, a.
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells
Mol. Cell. Biol.
14
5961-5974
1994
Mus musculus (P36895), Mus musculus
ten Dijke, P.; Ichijo, H.; Franzen, P.; Schulz, P.; Saras, J.; Toyoshima, H.; Heldin, C.H.; Miyazono, K.
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity
Oncogene
8
2879-2887
1993
Homo sapiens (P36894), Homo sapiens (P37023), Homo sapiens (Q04771), Homo sapiens, Mus musculus (P36898)
Ebner, R.; Chen, R.H.; Shum, L.; Lawler, S.; Zioncheck, T.F.; Lee, A.; Lopez, A.R.; Derynck, R.
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor
Science
260
1344-1348
1993
Mus musculus (P37172)
Attisano, L.; Wrana, J.L.; Cheifetz, S.; Massague, J.
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
Cell
68
97-108
1992
Mus musculus (P27040)
Mathews, L.S.; Vale, W.W.
Expression cloning of an activin receptor, a predicted transmembrane serine kinase
Cell
65
973-982
1991
Mus musculus (P27038)
Rechavi, G.; Givol, D.; Canaani, E.
Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element
Nature
300
607-611
1982
Mus musculus (P00536)
Van Beveren, C.; van Straaten, F.; Galleshaw, J.A.; Verma, I.M.
Nucleotide sequence of the genome of a murine sarcoma virus
Cell
27
97-108
1981
Mus musculus (P00536), Moloney murine sarcoma virus (P00538)
Li, F.; Liu, J.; Mayne, R.; Wu, C.
Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase
Biochim. Biophys. Acta
1358
215-220
1997
Homo sapiens (Q13418), Mus musculus (O55222)
Toshima, J.; Nakagawara, K.; Mori, M.; Noda, T.; Mizuno, K.
Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene
Gene
206
237-245
1998
Mus musculus (O70146), Mus musculus
Trofimova, M.; Sprenkle, A.B.; Green, M.; Sturgill, T.W.; Goebl, M.G.; Harrington, M.A.
Developmental and tissue-specific expression of mouse pelle-like protein kinase
J. Biol. Chem.
271
17609-17612
1996
Mus musculus (Q62406)
Stanger, B.Z.; Leder, P.; Lee, T.H.; Kim, E.; Seed, B.
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
Cell
81
513-523
1995
Homo sapiens (Q13546), Mus musculus (Q60855)
Pazdernik, N.J.; Donner, D.B.; Goebl, M.G.; Harrington, M.A.
Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB
Mol. Cell. Biol.
19
6500-6508
1999
Mus musculus (Q9QZl0), Mus musculus
Honda, R.; Ohba, Y.; Yasuda, H.
14-3-3 Zeta protein binds to the carboxyl half of mouse wee1 kinase
Biochem. Biophys. Res. Commun.
230
262-265
1997
Mus musculus (P47810)
Honda, R.; Tanaka, H.; Ohba, Y.; Yasuda, H.
Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation
Chromosome Res.
3
300-308
1995
Mus musculus (P47810)
Anastasiadou, E.; Schwaller, J.
Role of constitutively activated protein tyrosine kinases in malignant myeloproliferative disorders: an update
Curr. Opin. Hematol.
10
40-48
2003
Homo sapiens, Mus musculus
Senis, Y.A.; Craig, A.W.; Greer, P.A.
Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis
Exp. Hematol.
31
673-681
2003
Mus musculus
Sangrar, W.; Gao, Y.; Bates, B.; Zirngibl, R.; Greer, P.A.
Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival
Exp. Hematol.
32
935-945
2004
Mus musculus
Law, S.; Maiti, D.; Palit, A.; Chaudhuri, S.
Role of biomodulators and involvement of protein tyrosine kinase on stem cell migration in normal and leukaemic mice
Immunol. Lett.
86
287-290
2003
Mus musculus
Gevrey, J.C.; Isaac, B.M.; Cox, D.
Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine)
J. Immunol.
175
3737-3745
2005
Mus musculus
Arnaud, L.; Ballif, B.A.; Cooper, J.A.
Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
Mol. Cell. Biol.
23
9293-9302
2003
Mus musculus, Mus musculus C57BL6J/129Sv
Meyn, M.A., 3rd; Schreiner, S.J.; Dumitrescu, T.P.; Nau, G.J.; Smithgall, T.E.
Src family kinase activity is required for murine embryonic stem cell growth and differentiation
Mol. Pharmacol.
68
1320-1330
2005
Mus musculus
Okutani, D.; Lodyga, M.; Han, B.; Liu, M.
Src protein tyrosine kinase family and acute inflammatory responses
Am. J. Physiol. Lung Cell Mol. Physiol.
291
L129-L141
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Wallace, T.A.; Sayeski, P.P.
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
Cell Biochem. Biophys.
44
213-222
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Matsui, A.; Okigaki, M.; Amano, K.; Adachi, Y.; Jin, D.; Takai, S.; Yamashita, T.; Kawashima, S.; Kurihara, T.; Miyazaki, M.; Tateishi, K.; Matsunaga, S.; Katsume, A.; Honshou, S.; Takahashi, T.; Matoba, S.; Kusaba, T.; Tatsumi, T.; Matsubara, H.
Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function
Circulation
116
1041-1051
2007
Mus musculus
Angelucci, A.; Bologna, M.
Targeting vascular cell migration as a strategy for blocking angiogenesis: the central role of focal adhesion protein tyrosine kinase family
Curr. Pharm. Des.
13
2129-2145
2007
Homo sapiens, Mus musculus
Ortolano, S.; Hwang, I.Y.; Han, S.B.; Kehrl, J.H.
Roles for phosphoinositide 3-kinases, Brutons tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing
Eur. J. Immunol.
36
1285-1295
2006
Homo sapiens, Mus musculus
Frenzel, K.; Wallace, T.A.; McDoom, I.; Xiao, H.D.; Capecchi, M.R.; Bernstein, K.E.; Sayeski, P.P.
A functional Jak2 tyrosine kinase domain is essential for mouse development
Exp. Cell Res.
312
2735-2744
2006
Mus musculus (Q62120), Mus musculus
Zarbock, A.; Lowell, C.A.; Ley, K.
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1
Immunity
26
773-783
2007
Mus musculus
McGarrigle, D.; Shan, D.; Yang, S.; Huang, X.Y.
Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration
J. Biol. Chem.
281
10583-10588
2006
Mus musculus
Schmidt, N.W.; Thieu, V.T.; Mann, B.A.; Ahyi, A.N.; Kaplan, M.H.
Brutons tyrosine kinase is required for TLR-induced IL-10 production
J. Immunol.
177
7203-7210
2006
Mus musculus, Mus musculus C57BL/6
Gururajan, M.; Dasu, T.; Shahidain, S.; Jennings, C.D.; Robertson, D.A.; Rangnekar, V.M.; Bondada, S.
Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth
J. Immunol.
178
111-121
2007
Homo sapiens, Mus musculus
Pereira, D.B.; Chao, M.V.
The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts
J. Neurosci.
27
4859-4869
2007
Mus musculus, Rattus norvegicus
Sirvent, A.; Boureux, A.; Simon, V.; Leroy, C.; Roche, S.
The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells
Oncogene
26
7313-7323
2007
Homo sapiens, Mus musculus
Li, C.H.; Zhang, Q.; Teng, B.; Mustafa, S.J.; Huang, J.Y.; Yu, H.G.
Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531
Am. J. Physiol. Cell Physiol.
294
C355-C362
2008
Mus musculus, Homo sapiens (P12931)
Yin, H.; Liu, J.; Li, Z.; Berndt, M.C.; Lowell, C.A.; Du, X.
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway
Blood
112
1139-1146
2008
Mus musculus (P25911)
Shinohara, M.; Koga, T.; Okamoto, K.; Sakaguchi, S.; Arai, K.; Yasuda, H.; Takai, T.; Kodama, T.; Morio, T.; Geha, R.S.; Kitamura, D.; Kurosaki, T.; Ellmeier, W.; Takayanagi, H.
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals
Cell
132
794-806
2008
Mus musculus (P24604), Mus musculus (P35991)
Tsuda, M.; Tozaki-Saitoh, H.; Masuda, T.; Toyomitsu, E.; Tezuka, T.; Yamamoto, T.; Inoue, K.
Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury
Glia
56
50-58
2008
Mus musculus (P25911), Rattus norvegicus (Q07014)
Lee, Y.G.; Chain, B.M.; Cho, J.Y.
Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaBalpha via activation of the phosphoinositide-3-kinase and Akt pathways
Int. J. Biochem. Cell Biol.
41
811-821
2009
Mus musculus (P48025)
Lee, K.G.; Xu, S.; Wong, E.T.; Tergaonkar, V.; Lam, K.P.
Brutons tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B Cells
J. Biol. Chem.
283
11189-11198
2008
Mus musculus
Lee, S.H.; Kim, T.; Jeong, D.; Kim, N.; Choi, Y.
The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation
J. Biol. Chem.
283
11526-11534
2008
Mus musculus
Williams, N.K.; Lucet, I.S.; Klinken, S.P.; Ingley, E.; Rossjohn, J.
Crystal structures of the Lyn protein tyrosine kinase domain in its apo- and inhibitor-bound state
J. Biol. Chem.
284
284-291
2009
Mus musculus
Jongstra-Bilen, J.; Puig Cano, A.; Hasija, M.; Xiao, H.; Smith, C.I.; Cybulsky, M.I.
Dual functions of Brutons tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis
J. Immunol.
181
288-298
2008
Mus musculus, Mus musculus (P24604)
Jelacic, T.M.; Thompson, D.; Hanson, C.; Cmarik, J.L.; Nishigaki, K.; Ruscetti, S.
The tyrosine kinase sf-Stk and its downstream signals are required for maintenance of friend spleen focus-forming virus-induced fibroblast transformation
J. Virol.
82
419-427
2008
Mus musculus
MacPartlin, M.; Smith, A.M.; Druker, B.J.; Honigberg, L.A.; Deininger, M.W.
Brutons tyrosine kinase is not essential for Bcr-Abl-mediated transformation of lymphoid or myeloid cells
Leukemia
22
1354-1360
2008
Mus musculus
Chaturvedi, G.; Arai, K.; Terranova, P.F.; Roby, K.F.
The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion
Mol. Cell. Biochem.
318
191-200
2008
Mus musculus
Parsa, K.V.; Butchar, J.P.; Rajaram, M.V.; Cremer, T.J.; Tridandapani, S.
The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk
Mol. Immunol.
45
3012-3021
2008
Mus musculus, Homo sapiens (P43405)
Furuhata, A.; Kimura, A.; Shide, K.; Shimoda, K.; Murakami, M.; Ito, H.; Gao, S.; Yoshida, K.; Tagawa, Y.; Hagiwara, K.; Takagi, A.; Kojima, T.; Suzuki, M.; Abe, A.; Naoe, T.; Murate, T.
p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation
Biochem. Biophys. Res. Commun.
383
411-416
2009
Mus musculus (Q62120)
Pesu, M.; Laurence, A.; Kishore, N.; Zwillich, S.H.; Chan, G.; OShea, J.J.
Therapeutic targeting of Janus kinases
Immunol. Rev.
223
132-142
2008
Homo sapiens, Mus musculus
Ghoreschi, K.; Laurence, A.; OShea, J.J.
Janus kinases in immune cell signaling
Immunol. Rev.
228
273-287
2009
Homo sapiens, Mus musculus
Walz, C.; Cross, N.C.; Van Etten, R.A.; Reiter, A.
Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders
Leukemia
22
1320-1334
2008
Homo sapiens, Mus musculus
Kim, E.J.; Monje, F.J.; Li, L.; Hoeger, H.; Pollak, D.D.; Lubec, G.
Alzheimer's disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory
Cell. Mol. Life Sci.
70
743-759
2013
Mus musculus
Bao, Y.; Zheng, J.; Han, C.; Jin, J.; Han, H.; Liu, Y.; Lau, Y.; Tu, W.; Cao, X.
Tyrosine kinase Btk is required for NK cell activation
J. Biol. Chem.
287
23769-23778
2012
Mus musculus (P35991), Mus musculus, Homo sapiens (Q06187), Homo sapiens
Lin, Y.L.; Roux, B.
Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases
J. Am. Chem. Soc.
135
14741-14753
2013
Mus musculus (P00520), Gallus gallus (P00523), Homo sapiens (P06239)
Nuendel, K.; Busto, P.; Debatis, M.; Marshak-Rothstein, A.
The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells
J. Leukoc. Biol.
94
865-875
2013
Mus musculus (P35991)
De Lucca, G.; Shi, Q.; Liu, Q.; Batt, D.; Beaudoin Bertrand, M.; Rampulla, R.; Mathur, A.; Discenza, L.; DArienzo, C.; Dai, J.; Obermeier, M.; Vickery, R.; Zhang, Y.; Yang, Z.; Marathe, P.; Tebben, A.; Muckelbauer, J.; Chang, C.; Zhang, H.; Gillooly, K.;
Small molecule reversible inhibitors of Bruton's tyrosine kinase (BTK): structure-activity relationships leading to the identification of 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)
J. Med. Chem.
59
7915-7935
2016
Mus musculus (P35991)
Francis, K.R.; Wei, L.; Yu, S.P.
Src tyrosine kinases regulate neuronal differentiation of mouse embryonic stem cells via modulation of voltage-gated sodium channel activity
Neurochem. Res.
40
674-687
2015
Mus musculus
Dasari, T.; Geiger, R.; Karki, R.; Banoth, B.; Sharma, B.; Gurung, P.; Burton, A.; Kanneganti, T.
The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis
J. Biol. Chem.
295
3394-3400
2020
Homo sapiens (P43405), Homo sapiens, Mus musculus (P48025), Mus musculus
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