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ATP + a protein
ADP + a phosphoprotein
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
ATP + Bad protein
ADP + phosphotyrosinyl Bad protein
-
substrate of Akt
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
-
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
-
-
-
-
?
ATP + Cbp
? + ADP
-
murine Csk binding protein, Cbp, amino acids 74-474, substrate used in kinase activity assay
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
-
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
-
-
-
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
-
-
-
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
-
substrate of Akt
-
-
?
ATP + KVEKIGEGTYGVVYK
? + ADP
substrate peptide used in kinase activity assay, derived from p34cdc2
-
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
-
-
-
-
?
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
-
-
-
-
?
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
-
-
-
-
?
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
-
-
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
-
-
-
-
?
ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
-
-
-
-
?
ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
-
-
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
-
substrate HCN4, tyrosine 531 is phosphorylated
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
additional information
?
-
ATP + a protein
ADP + a phosphoprotein
serine-threonine kinase
-
-
?
ATP + a protein
ADP + a phosphoprotein
role for this kinase in spermatogenesis
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is a substrate of Src, phosphorylation on Tyr245 and Tyr412
-
-
?
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
-
-
-
-
?
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
-
tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
phosphorylation by Jak2 at tyrosine residues
-
-
?
additional information
?
-
the bone morphogenetic protein receptor binds bone morphogenetic protein 2 and bone morphogenetic protein 4
-
-
?
additional information
?
-
the bone morphogenetic protein receptor binds bone morphogenetic protein 2 and bone morphogenetic protein 4
-
-
?
additional information
?
-
-
the bone morphogenetic protein receptor binds bone morphogenetic protein 2 and bone morphogenetic protein 4
-
-
?
additional information
?
-
all isoforms of the activin receptor type II bind inhibin A with low affinity
-
-
?
additional information
?
-
activates NF-kappaB
-
-
?
additional information
?
-
-
activates NF-kappaB
-
-
?
additional information
?
-
role for JAK3 in hematopoiesis and T- and B-cell development
-
-
?
additional information
?
-
involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
-
-
?
additional information
?
-
JAK3 kinase is associated with terminal differentiation of hematopoietic cells
-
-
?
additional information
?
-
the enzyme transduces signals initiated by integrin engagement and G protein-coupled receptors. Several splice isoforms of FAK are preferentially expressed in rat brain, some of which have an increased autophosphorylation activity
-
-
?
additional information
?
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
enzyme is involved in pathway for signaling through glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins
-
-
?
additional information
?
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
may interact with the intracellular domain of cell surface receptors
-
-
?
additional information
?
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
-
-
?
additional information
?
-
perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Syk-deficient radiation chimaeras fail to accumulate mature B cells, Syk-deficient mice show impaired development of thymocytes using the V gamma 3 variable region gene, Syk is not required for signalling through the IL-2 and G-CSF receptors
-
-
?
additional information
?
-
Rlk has potential functions in intrathymic T cell development and mature T cell signaling
-
-
?
additional information
?
-
Ntk may play an inhibitory role in the control of T-cell proliferation
-
-
?
additional information
?
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
activating motif occurs in four discrete steps: binding of p59fyn, phosphorylation of the motif, binding of ZAP-70, and activation of ZAP-70 kinase activity
-
-
?
additional information
?
-
Ctk is involved in the regulation of neural function and differentiation of male germ cells through interactions with members of the Src family kinases
-
-
?
additional information
?
-
could be responsible for the tyrosine phosphorylation observed in a murine thymic medullary epithelial cell line E-5 following complex formation with thymocytes
-
-
?
additional information
?
-
type II receptor isoforma exist which play preferential binding to TGF-beta2 and have their own defined role in debvelopment
-
-
?
additional information
?
-
mRIP3 uses a novel mechanism to induce death
-
-
?
additional information
?
-
-
mRIP3 uses a novel mechanism to induce death
-
-
?
additional information
?
-
in a cell cycle the wee1 kinase is phosphorylated at M-phase, phosphorylation occurs in the N-terminal domain resulting in inactivation of the kinase activity. The N-terminal domain, or the entire molecule is extensively phosphorylated by cdc2-cyclin B kinase
-
-
?
additional information
?
-
-
CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview
-
-
?
additional information
?
-
-
Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis
-
-
?
additional information
?
-
-
Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival
-
-
?
additional information
?
-
-
protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview
-
-
?
additional information
?
-
-
Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview
-
-
?
additional information
?
-
-
the enzyme plays an important role in the self-renewal and as comitogen in the movement of stem cells out of the haematopoietic stem cell pool into the progeny pool, regulation of bone marrow cell migration
-
-
?
additional information
?
-
-
the BCR/ABL kinase performs tyrosine autophosphorylation, mechanism
-
-
?
additional information
?
-
-
Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview
-
-
?
additional information
?
-
-
Csk is essential for mouse embryonic development, Csk plays a role in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration, overview, modeling of Csk regulation of focal adhesion turnover
-
-
?
additional information
?
-
-
enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo
-
-
?
additional information
?
-
-
Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
-
-
?
additional information
?
-
-
PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview
-
-
?
additional information
?
-
-
spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1, neutrophil activation pathways, overview
-
-
?
additional information
?
-
-
Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation
-
-
?
additional information
?
-
-
Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview
-
-
?
additional information
?
-
-
the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity
-
-
?
additional information
?
-
the enzyme is involved in cytokine signaling
-
-
?
additional information
?
-
-
the enzyme is involved in cytokine signaling
-
-
?
additional information
?
-
-
tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling
-
-
?
additional information
?
-
-
Abl does not mediate tyrosine phosphorylation of Stat3 and Shc, two important regulators of Src oncogenic activity
-
-
?
additional information
?
-
-
Fak binds interaction partners, e.g. paxillin, talin, and p190RhoGEF, at the FAT domain, i.e. the focal adhesion targeting domain, at the C-terminal domain modulaing the Fak activity, overview
-
-
?
additional information
?
-
-
receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another
-
-
?
additional information
?
-
-
Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + a protein
ADP + a phosphoprotein
role for this kinase in spermatogenesis
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
-
Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview
-
-
?
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
-
tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview
-
-
?
ATP + Bad protein
ADP + phosphotyrosinyl Bad protein
-
substrate of Akt
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
-
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
-
-
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
-
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
-
-
-
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
-
-
-
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
-
substrate of Akt
-
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
-
-
-
-
?
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
-
-
-
-
?
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
-
-
-
-
?
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
-
-
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
-
-
-
-
?
ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
-
-
-
-
?
ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
-
-
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
-
-
?
additional information
?
-
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
-
-
-
?
additional information
?
-
role for JAK3 in hematopoiesis and T- and B-cell development
-
-
?
additional information
?
-
involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
-
-
?
additional information
?
-
JAK3 kinase is associated with terminal differentiation of hematopoietic cells
-
-
?
additional information
?
-
the enzyme transduces signals initiated by integrin engagement and G protein-coupled receptors. Several splice isoforms of FAK are preferentially expressed in rat brain, some of which have an increased autophosphorylation activity
-
-
?
additional information
?
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
-
activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix
-
-
?
additional information
?
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
-
lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes
-
-
?
additional information
?
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
-
enzyme is implicated in neoplastic transformation
-
-
?
additional information
?
-
enzyme is involved in pathway for signaling through glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins
-
-
?
additional information
?
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
-
elevated levels of p56tck can contribute to the malignant properties of LSTRA cells
-
-
?
additional information
?
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
-
p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation
-
-
?
additional information
?
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
-
p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases
-
-
?
additional information
?
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
-
may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis
-
-
?
additional information
?
-
may interact with the intracellular domain of cell surface receptors
-
-
?
additional information
?
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
-
participates in the signalling pathways of a broad range of cytokines
-
-
?
additional information
?
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
-
enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells
-
-
?
additional information
?
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
-
directly implicated in the pathogenesis of X-linked agammaglobulinaemia
-
-
?
additional information
?
-
deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
-
-
?
additional information
?
-
perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Syk-deficient radiation chimaeras fail to accumulate mature B cells, Syk-deficient mice show impaired development of thymocytes using the V gamma 3 variable region gene, Syk is not required for signalling through the IL-2 and G-CSF receptors
-
-
?
additional information
?
-
Rlk has potential functions in intrathymic T cell development and mature T cell signaling
-
-
?
additional information
?
-
Ntk may play an inhibitory role in the control of T-cell proliferation
-
-
?
additional information
?
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
-
role for JAK1 kinase in the differentiation or function of a subset of CNS neurons
-
-
?
additional information
?
-
activating motif occurs in four discrete steps: binding of p59fyn, phosphorylation of the motif, binding of ZAP-70, and activation of ZAP-70 kinase activity
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additional information
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Ctk is involved in the regulation of neural function and differentiation of male germ cells through interactions with members of the Src family kinases
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additional information
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could be responsible for the tyrosine phosphorylation observed in a murine thymic medullary epithelial cell line E-5 following complex formation with thymocytes
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additional information
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type II receptor isoforma exist which play preferential binding to TGF-beta2 and have their own defined role in debvelopment
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additional information
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mRIP3 uses a novel mechanism to induce death
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additional information
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mRIP3 uses a novel mechanism to induce death
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additional information
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in a cell cycle the wee1 kinase is phosphorylated at M-phase, phosphorylation occurs in the N-terminal domain resulting in inactivation of the kinase activity. The N-terminal domain, or the entire molecule is extensively phosphorylated by cdc2-cyclin B kinase
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additional information
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CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview
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additional information
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Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis
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additional information
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Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival
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additional information
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protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview
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additional information
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Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview
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additional information
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the enzyme plays an important role in the self-renewal and as comitogen in the movement of stem cells out of the haematopoietic stem cell pool into the progeny pool, regulation of bone marrow cell migration
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additional information
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Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview
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additional information
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Csk is essential for mouse embryonic development, Csk plays a role in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration, overview, modeling of Csk regulation of focal adhesion turnover
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additional information
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enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo
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additional information
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Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
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additional information
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PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview
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additional information
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spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1, neutrophil activation pathways, overview
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additional information
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Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation
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additional information
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Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview
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additional information
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the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity
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additional information
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the enzyme is involved in cytokine signaling
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additional information
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the enzyme is involved in cytokine signaling
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additional information
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tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
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Mus musculus (Q64434), Mus musculus
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Mus musculus (O35607), Mus musculus
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Wu, X.; Robinson, C.E.; Fong, H.W.; Crabtree, J.S.; Rodriguez, B.R.; Roe, B.A.; Gimble, J.M.
Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog
Biochem. Biophys. Res. Commun.
216
78-83
1995
Mus musculus (Q61288)
brenda
Dewulf, N.; Verschueren, K.; Lonnoy, O.; Moren, A.; Grimsby, S.; Vande Spiegle, K.; Miyazono, K.; Huylebroeck, D.; Ten Dijke, P.
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
Endocrinology
136
2652-2663
1995
Mus musculus (P36895), Mus musculus (Q61288)
brenda
Tomoda, T.; Kudoh, T.; Noma, T.; Nakazawa, A.; Muramatsu, M.; Arai, K.
Molecular cloning of a mouse counterpart for human TGF-beta type I receptor
Biochem. Biophys. Res. Commun.
198
1054-1062
1994
Mus musculus (Q64729)
brenda
ten Dijke, P.; Yamashita, H.; Ichijo, H.; Franzen, P.; Laiho, M.; Miyazono, K.; Heldin, C.H.
Characterization of type I receptors for transforming growth factor-beta and activin
Science
264
101-104
1994
Mus musculus (P36898)
brenda
Suzuki, A.; Shioda, N.; Maeda, T.; Tada, M.; Ueno, N.
Cloning of an isoform of mouse TGF-beta type II receptor gene
FEBS Lett.
355
19-22
1994
Mus musculus (Q62312), Mus musculus
brenda
Suzuki, A.; Thies, R.S.; Yamaji, N.; Song, J.J.; Wozney, J.M.; Murakami, K.; Ueno, N.
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
Proc. Natl. Acad. Sci. USA
91
10255-10259
1994
Mus musculus (P36895)
brenda
Suzuki, A.; Shioda, N.; Maeda, T.; Tada, M.; Ueno, N.
A mouse TGF-beta type I receptor that requires type II receptor for ligand binding
Biochem. Biophys. Res. Commun.
198
1063-1069
1994
Mus musculus (Q64729), Mus musculus
brenda
Lawler, S.; Candia, A.F.; Ebner, R.; Shum, L.; Lopez, A.R.; Moses, H.L.; Wright, C.V.; Derynck, R.
The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1
Development
120
165-175
1994
Mus musculus (Q62312)
brenda
Koenig, B.B.; Cook, J.S.; Wolsing, D.H.; Ting, J.; Tiesman, J.P.; Correa, P.E.; Olson, C.A.; Pecquet, A.L.; Ventura, F.; Grant, R.A.; et, a.
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells
Mol. Cell. Biol.
14
5961-5974
1994
Mus musculus (P36895), Mus musculus
brenda
ten Dijke, P.; Ichijo, H.; Franzen, P.; Schulz, P.; Saras, J.; Toyoshima, H.; Heldin, C.H.; Miyazono, K.
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity
Oncogene
8
2879-2887
1993
Homo sapiens (P36894), Homo sapiens (P37023), Homo sapiens (Q04771), Homo sapiens, Mus musculus (P36898)
brenda
Ebner, R.; Chen, R.H.; Shum, L.; Lawler, S.; Zioncheck, T.F.; Lee, A.; Lopez, A.R.; Derynck, R.
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor
Science
260
1344-1348
1993
Mus musculus (P37172)
brenda
Attisano, L.; Wrana, J.L.; Cheifetz, S.; Massague, J.
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
Cell
68
97-108
1992
Mus musculus (P27040)
brenda
Mathews, L.S.; Vale, W.W.
Expression cloning of an activin receptor, a predicted transmembrane serine kinase
Cell
65
973-982
1991
Mus musculus (P27038)
brenda
Rechavi, G.; Givol, D.; Canaani, E.
Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element
Nature
300
607-611
1982
Mus musculus (P00536)
brenda
Van Beveren, C.; van Straaten, F.; Galleshaw, J.A.; Verma, I.M.
Nucleotide sequence of the genome of a murine sarcoma virus
Cell
27
97-108
1981
Mus musculus (P00536), Moloney murine sarcoma virus (P00538)
brenda
Li, F.; Liu, J.; Mayne, R.; Wu, C.
Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase
Biochim. Biophys. Acta
1358
215-220
1997
Homo sapiens (Q13418), Mus musculus (O55222)
brenda
Toshima, J.; Nakagawara, K.; Mori, M.; Noda, T.; Mizuno, K.
Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene
Gene
206
237-245
1998
Mus musculus (O70146), Mus musculus
brenda
Trofimova, M.; Sprenkle, A.B.; Green, M.; Sturgill, T.W.; Goebl, M.G.; Harrington, M.A.
Developmental and tissue-specific expression of mouse pelle-like protein kinase
J. Biol. Chem.
271
17609-17612
1996
Mus musculus (Q62406)
brenda
Stanger, B.Z.; Leder, P.; Lee, T.H.; Kim, E.; Seed, B.
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
Cell
81
513-523
1995
Homo sapiens (Q13546), Mus musculus (Q60855)
brenda
Pazdernik, N.J.; Donner, D.B.; Goebl, M.G.; Harrington, M.A.
Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB
Mol. Cell. Biol.
19
6500-6508
1999
Mus musculus (Q9QZl0), Mus musculus
brenda
Honda, R.; Ohba, Y.; Yasuda, H.
14-3-3 Zeta protein binds to the carboxyl half of mouse wee1 kinase
Biochem. Biophys. Res. Commun.
230
262-265
1997
Mus musculus (P47810)
brenda
Honda, R.; Tanaka, H.; Ohba, Y.; Yasuda, H.
Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation
Chromosome Res.
3
300-308
1995
Mus musculus (P47810)
brenda
Anastasiadou, E.; Schwaller, J.
Role of constitutively activated protein tyrosine kinases in malignant myeloproliferative disorders: an update
Curr. Opin. Hematol.
10
40-48
2003
Homo sapiens, Mus musculus
brenda
Senis, Y.A.; Craig, A.W.; Greer, P.A.
Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis
Exp. Hematol.
31
673-681
2003
Mus musculus
brenda
Sangrar, W.; Gao, Y.; Bates, B.; Zirngibl, R.; Greer, P.A.
Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival
Exp. Hematol.
32
935-945
2004
Mus musculus
brenda
Law, S.; Maiti, D.; Palit, A.; Chaudhuri, S.
Role of biomodulators and involvement of protein tyrosine kinase on stem cell migration in normal and leukaemic mice
Immunol. Lett.
86
287-290
2003
Mus musculus
brenda
Gevrey, J.C.; Isaac, B.M.; Cox, D.
Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine)
J. Immunol.
175
3737-3745
2005
Mus musculus
brenda
Arnaud, L.; Ballif, B.A.; Cooper, J.A.
Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
Mol. Cell. Biol.
23
9293-9302
2003
Mus musculus, Mus musculus C57BL6J/129Sv
brenda
Meyn, M.A., 3rd; Schreiner, S.J.; Dumitrescu, T.P.; Nau, G.J.; Smithgall, T.E.
Src family kinase activity is required for murine embryonic stem cell growth and differentiation
Mol. Pharmacol.
68
1320-1330
2005
Mus musculus
brenda
Okutani, D.; Lodyga, M.; Han, B.; Liu, M.
Src protein tyrosine kinase family and acute inflammatory responses
Am. J. Physiol. Lung Cell Mol. Physiol.
291
L129-L141
2006
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Wallace, T.A.; Sayeski, P.P.
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
Cell Biochem. Biophys.
44
213-222
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
brenda
Matsui, A.; Okigaki, M.; Amano, K.; Adachi, Y.; Jin, D.; Takai, S.; Yamashita, T.; Kawashima, S.; Kurihara, T.; Miyazaki, M.; Tateishi, K.; Matsunaga, S.; Katsume, A.; Honshou, S.; Takahashi, T.; Matoba, S.; Kusaba, T.; Tatsumi, T.; Matsubara, H.
Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function
Circulation
116
1041-1051
2007
Mus musculus
brenda
Angelucci, A.; Bologna, M.
Targeting vascular cell migration as a strategy for blocking angiogenesis: the central role of focal adhesion protein tyrosine kinase family
Curr. Pharm. Des.
13
2129-2145
2007
Homo sapiens, Mus musculus
brenda
Ortolano, S.; Hwang, I.Y.; Han, S.B.; Kehrl, J.H.
Roles for phosphoinositide 3-kinases, Brutons tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing
Eur. J. Immunol.
36
1285-1295
2006
Homo sapiens, Mus musculus
brenda
Frenzel, K.; Wallace, T.A.; McDoom, I.; Xiao, H.D.; Capecchi, M.R.; Bernstein, K.E.; Sayeski, P.P.
A functional Jak2 tyrosine kinase domain is essential for mouse development
Exp. Cell Res.
312
2735-2744
2006
Mus musculus (Q62120), Mus musculus
brenda
Zarbock, A.; Lowell, C.A.; Ley, K.
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1
Immunity
26
773-783
2007
Mus musculus
brenda
McGarrigle, D.; Shan, D.; Yang, S.; Huang, X.Y.
Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration
J. Biol. Chem.
281
10583-10588
2006
Mus musculus
brenda
Schmidt, N.W.; Thieu, V.T.; Mann, B.A.; Ahyi, A.N.; Kaplan, M.H.
Brutons tyrosine kinase is required for TLR-induced IL-10 production
J. Immunol.
177
7203-7210
2006
Mus musculus, Mus musculus C57BL/6
brenda
Gururajan, M.; Dasu, T.; Shahidain, S.; Jennings, C.D.; Robertson, D.A.; Rangnekar, V.M.; Bondada, S.
Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth
J. Immunol.
178
111-121
2007
Homo sapiens, Mus musculus
brenda
Pereira, D.B.; Chao, M.V.
The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts
J. Neurosci.
27
4859-4869
2007
Mus musculus, Rattus norvegicus
brenda
Sirvent, A.; Boureux, A.; Simon, V.; Leroy, C.; Roche, S.
The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells
Oncogene
26
7313-7323
2007
Homo sapiens, Mus musculus
brenda
Li, C.H.; Zhang, Q.; Teng, B.; Mustafa, S.J.; Huang, J.Y.; Yu, H.G.
Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531
Am. J. Physiol. Cell Physiol.
294
C355-C362
2008
Mus musculus, Homo sapiens (P12931)
brenda
Yin, H.; Liu, J.; Li, Z.; Berndt, M.C.; Lowell, C.A.; Du, X.
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway
Blood
112
1139-1146
2008
Mus musculus (P25911)
brenda
Shinohara, M.; Koga, T.; Okamoto, K.; Sakaguchi, S.; Arai, K.; Yasuda, H.; Takai, T.; Kodama, T.; Morio, T.; Geha, R.S.; Kitamura, D.; Kurosaki, T.; Ellmeier, W.; Takayanagi, H.
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals
Cell
132
794-806
2008
Mus musculus (P24604), Mus musculus (P35991)
brenda
Tsuda, M.; Tozaki-Saitoh, H.; Masuda, T.; Toyomitsu, E.; Tezuka, T.; Yamamoto, T.; Inoue, K.
Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury
Glia
56
50-58
2008
Mus musculus (P25911), Rattus norvegicus (Q07014)
brenda
Lee, Y.G.; Chain, B.M.; Cho, J.Y.
Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaBalpha via activation of the phosphoinositide-3-kinase and Akt pathways
Int. J. Biochem. Cell Biol.
41
811-821
2009
Mus musculus (P48025)
brenda
Lee, K.G.; Xu, S.; Wong, E.T.; Tergaonkar, V.; Lam, K.P.
Brutons tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B Cells
J. Biol. Chem.
283
11189-11198
2008
Mus musculus
brenda
Lee, S.H.; Kim, T.; Jeong, D.; Kim, N.; Choi, Y.
The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation
J. Biol. Chem.
283
11526-11534
2008
Mus musculus
brenda
Williams, N.K.; Lucet, I.S.; Klinken, S.P.; Ingley, E.; Rossjohn, J.
Crystal structures of the Lyn protein tyrosine kinase domain in its apo- and inhibitor-bound state
J. Biol. Chem.
284
284-291
2009
Mus musculus
brenda
Jongstra-Bilen, J.; Puig Cano, A.; Hasija, M.; Xiao, H.; Smith, C.I.; Cybulsky, M.I.
Dual functions of Brutons tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis
J. Immunol.
181
288-298
2008
Mus musculus, Mus musculus (P24604)
brenda
Jelacic, T.M.; Thompson, D.; Hanson, C.; Cmarik, J.L.; Nishigaki, K.; Ruscetti, S.
The tyrosine kinase sf-Stk and its downstream signals are required for maintenance of friend spleen focus-forming virus-induced fibroblast transformation
J. Virol.
82
419-427
2008
Mus musculus
brenda
MacPartlin, M.; Smith, A.M.; Druker, B.J.; Honigberg, L.A.; Deininger, M.W.
Brutons tyrosine kinase is not essential for Bcr-Abl-mediated transformation of lymphoid or myeloid cells
Leukemia
22
1354-1360
2008
Mus musculus
brenda
Chaturvedi, G.; Arai, K.; Terranova, P.F.; Roby, K.F.
The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion
Mol. Cell. Biochem.
318
191-200
2008
Mus musculus
brenda
Parsa, K.V.; Butchar, J.P.; Rajaram, M.V.; Cremer, T.J.; Tridandapani, S.
The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk
Mol. Immunol.
45
3012-3021
2008
Mus musculus, Homo sapiens (P43405)
brenda
Furuhata, A.; Kimura, A.; Shide, K.; Shimoda, K.; Murakami, M.; Ito, H.; Gao, S.; Yoshida, K.; Tagawa, Y.; Hagiwara, K.; Takagi, A.; Kojima, T.; Suzuki, M.; Abe, A.; Naoe, T.; Murate, T.
p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation
Biochem. Biophys. Res. Commun.
383
411-416
2009
Mus musculus (Q62120)
brenda
Pesu, M.; Laurence, A.; Kishore, N.; Zwillich, S.H.; Chan, G.; OShea, J.J.
Therapeutic targeting of Janus kinases
Immunol. Rev.
223
132-142
2008
Homo sapiens, Mus musculus
brenda
Ghoreschi, K.; Laurence, A.; OShea, J.J.
Janus kinases in immune cell signaling
Immunol. Rev.
228
273-287
2009
Homo sapiens, Mus musculus
brenda
Walz, C.; Cross, N.C.; Van Etten, R.A.; Reiter, A.
Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders
Leukemia
22
1320-1334
2008
Homo sapiens, Mus musculus
brenda
Kim, E.J.; Monje, F.J.; Li, L.; Hoeger, H.; Pollak, D.D.; Lubec, G.
Alzheimer's disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory
Cell. Mol. Life Sci.
70
743-759
2013
Mus musculus
brenda
Bao, Y.; Zheng, J.; Han, C.; Jin, J.; Han, H.; Liu, Y.; Lau, Y.; Tu, W.; Cao, X.
Tyrosine kinase Btk is required for NK cell activation
J. Biol. Chem.
287
23769-23778
2012
Mus musculus (P35991), Mus musculus, Homo sapiens (Q06187), Homo sapiens
brenda
Lin, Y.L.; Roux, B.
Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases
J. Am. Chem. Soc.
135
14741-14753
2013
Mus musculus (P00520), Gallus gallus (P00523), Homo sapiens (P06239)
brenda
Nuendel, K.; Busto, P.; Debatis, M.; Marshak-Rothstein, A.
The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells
J. Leukoc. Biol.
94
865-875
2013
Mus musculus (P35991)
brenda
De Lucca, G.; Shi, Q.; Liu, Q.; Batt, D.; Beaudoin Bertrand, M.; Rampulla, R.; Mathur, A.; Discenza, L.; DArienzo, C.; Dai, J.; Obermeier, M.; Vickery, R.; Zhang, Y.; Yang, Z.; Marathe, P.; Tebben, A.; Muckelbauer, J.; Chang, C.; Zhang, H.; Gillooly, K.;
Small molecule reversible inhibitors of Bruton's tyrosine kinase (BTK): structure-activity relationships leading to the identification of 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)
J. Med. Chem.
59
7915-7935
2016
Mus musculus (P35991)
brenda
Francis, K.R.; Wei, L.; Yu, S.P.
Src tyrosine kinases regulate neuronal differentiation of mouse embryonic stem cells via modulation of voltage-gated sodium channel activity
Neurochem. Res.
40
674-687
2015
Mus musculus
brenda
Dasari, T.; Geiger, R.; Karki, R.; Banoth, B.; Sharma, B.; Gurung, P.; Burton, A.; Kanneganti, T.
The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis
J. Biol. Chem.
295
3394-3400
2020
Homo sapiens (P43405), Homo sapiens, Mus musculus (P48025), Mus musculus
brenda
Llewellyn, R.; Thomas, K.; Gutknecht, M.; Bouton, A.
The nonreceptor protein tyrosine kinase Pyk2 promotes the turnover of monocytes at steady state
J. Leukoc. Biol.
102
1069-1080
2017
Mus musculus (Q9QVP9), Mus musculus
brenda