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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Homo sapiens and UniProt Accession P12931

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IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: P12931
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, v-src, janus kinase, p56lck, ephb4, janus kinase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70 kDa zeta-associated protein
-
-
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A-Raf proto-oncogene serine/threonine-protein kinase
266442
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Abelson murine leukemia viral homolog (1) protein
247
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Abelson tyrosine kinase
247
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Abl kinase
Abl nonreceptor tyrosine kinase
247
-
Abl protein tyrosine kinase
Abl tyrosine kinase
247
-
ABL1 tyrosine kinase
265446
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ABL2
247
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ABL2/ARG tyrosine kinase
247
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activated Cdc42-associated tyrosine kinase 1
298891
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activin receptor type I
266395
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activin receptor type II
266402
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ACTR-IIB
-
-
-
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ACTRIIA
-
-
-
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Agammaglobulinaemia tyrosine kinase
-
-
-
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AKT
247
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AL
247
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ALK
247
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Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
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anti-mullerian hormone type II receptor
266375
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ARG
247
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ATK
-
-
-
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B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
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B-cell/myeloid kinase
-
-
-
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B-Raf proto-oncogene serine/threonine-protein kinase
266446
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BCR-Abl
247
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Bcr-Abl kinase
265446
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BCR-ABL tyrosine kinase
BCR/ABL kinase
247
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BMK
-
-
-
-
BMP type II receptor
-
-
-
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BMP-2/BMP-4 receptor
-
-
-
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BMPR-IB
266379
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BMPR1A
266373
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Bmx tyrosine kinase
265597
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Bone marrow kinase BMX
-
-
-
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bone morphogenetic protein receptor type IA
266373
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bone morphogenetic protein receptor type IB
266379
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BPK
-
-
-
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Breast tumor kinase
breast tumour kinase
265661
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Bruton tyrosine kinase
265722
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Bruton's tyrosine kinase
Bruton's tyrosine kinase PH domain
247
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Brutons tyrosine kinase
Bruton’s tyrosine kinase
247
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Btk tyrosine kinase
247
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c-ABL
c-Abl tyrosine kinase
c-FER
-
-
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C-FES
-
-
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c-Fes protein-tyrosine kinase
247
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c-Fes tyrosine kinase
247
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C-SRC
C-SRC kinase
c-Src nonreceptor tyrosine kinase
247
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c-Src protein tyrosine kinase
247
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c-Src tyrosine kinase
247
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C-terminal Src kinase
247
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C-YES
CADTK
-
-
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CAK beta
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Calcium-dependent tyrosine kinase
-
-
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CARD-containing interleukin-1 beta converting enzyme associated kinase
266437
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CARDIAK
266437
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Cell adhesion kinase beta
-
-
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Chk tyrosine kinase
247
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Chk1
247
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Csk homologous kinase
247
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Csk protein-tyrosine kinase
247
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CSK-homologous kinase
247
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cytoplasmic protein tyrosine kinase
247
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cytoplasmic tyrosine-protein kinase BMX
265597
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D-ash
-
-
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DFer
-
-
-
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Dsrc28C
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ectoprotein kinase
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Epithelial and endothelial tyrosine kinase
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EPS I polysaccharide export protein epsB
-
-
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ETK
265597
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Etk/BMX
265597
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FADK1
247
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FADK2
247
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FAK2
247
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FER tyrosine kinase
265518
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Fes tyrosine kinase
247
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focal adhesion kinase 1
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focal adhesion protein tyrosine
247
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FPS
247
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Fyn kinase
247
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Fyn tyrosine kinase
247
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fyn-related kinase
265586
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gene lck protein kinase
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-
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gene lck tyrosine kinase
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Hematopoietic consensus tyrosine-lacking kinase
Hemopoietic cell kinase
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hFAK
265739
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HYL
265580
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IL-1R-associated kinase
266421
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IL-2-inducible T-cell kinase
-
-
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integrin-linked protein kinase 1
266418
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integrin-linked protein kinase 76
266418
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interleukin-1 receptor-associated kinase 1
266425
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interleukin-1 receptor-associated kinase-81
266421
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IRAK
266425
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IRAK-81
266421
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JAK
247
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JAK protein tyrosine kinase
-
-
-
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Jak tyrosine kinase
247
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Jak2 protein
265442
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JAK2 tyrosine kinase
247
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Janus family kinase JAK3
265599
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Janus kinase
Janus kinase 1
247
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Janus kinase 2
just another kinase
247
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Kinase EMB
-
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Kinase EMT
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Kinase TLK
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kinase, protein (phosphorylating tyrosine)
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kinase, protein p56lck (phosphorylating)
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L-JAK
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Lck Tyrosine kinase
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Leukocyte janus kinase
LIM domain kinase 2
266428
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LSK
-
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lymphocyte-specific protein tyrosine kinase
247
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Lyn tyrosine kinase
265478
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MATK
265580
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megakaryocyte-associated tyrosine-protein kinase
265580
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MIS type II receptor
266375
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non-receptor protein tyrosine kinase
247
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non-receptor protein-tyrosine kinase
247
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non-receptor PTK
247
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non-receptor tyrosine kinase
247
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non-receptor tyrosine kinase brk
265661
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non-receptor tyrosine-protein kinase TYK2
265556
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nonreceptor protein tyrosine kinase
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-
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nonreceptor tyrosine kinase
247
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nonreceptor tyrosine kinase Fes
265475
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NRTK
247
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NTK38
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-
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Nuclear tyrosine protein kinase RAK
-
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ORF6
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p135tyk2 tyrosine kinase
265556
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p150
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p55-BLK
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P55-FGR
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-
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p56-HCK
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p56-HCK/p59-HCK
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P56-LCK
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p56lck kinase
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p56lck protein kinase
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p56lck protein tyrosine kinase
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p56lck tyrosine kinase
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P57-STK
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P59-FYN
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p59-HCK/p60-HCK
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P60-SRC
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p60-YRK
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P61-YES
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p94-FER
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phosphotyrosyl-protein kinase
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PP125FAK
proline-rich tyrosin ekinase 2
247
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proline-rich tyrosine kinase 2
proline-rich tyrosine kinase-2
247
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Protein kinase (tyrosine-phosphorylating)
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protein kinase A
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Protein kinase BATK
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Protein kinase HYL
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Protein kinase Lck
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Protein kinase NTK
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Protein kinase p56-LCK
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Protein kinase p56lck
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Protein p56c-lck kinase
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Protein p56lck tyrosine kinase
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Protein tyrosine kinase
protein tyrosine kinase 2
247
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protein tyrosine kinase 2beta
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protein tyrosine kinase 6
265661
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protein tyrosine kinase focal adhesion kinase
247
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Protein tyrosine kinase lck
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Protein tyrosine kinase p56lck
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Protein tyrosine kinase pp56lck
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protein-tyrosine kinase
247
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protein-tyrosine kinase Brk
265661
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Protein-tyrosine kinase C-TKL
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Protein-tyrosine kinase CYL
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Protein-tyrosine kinase Syk
247
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proto-oncogene serine/threonine-protein kinase mos
266415
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proto-oncogene tyrosine-protein kinase ABL1
265446
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proto-oncogene tyrosine-protein kinase FER
265518
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proto-oncogene tyrosine-protein kinase FES/FPS
265475
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proto-oncogene tyrosine-protein kinase FYN
265473
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proto-oncogene tyrosine-protein kinase LCK
265711
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proto-oncogene tyrosine-protein kinase SRC
265497
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proto-oncogene tyrosine-protein kinase YES
265477
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PTK-RL-18
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-
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PTK2B
265743
gene name
PTK6
265661
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PTK6/Sik
247
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PTK70
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-
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Pyk-2
247
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Quek1
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RAF proto-oncogene serine/threonine-protein kinase
266439
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Raf-1 protein kinase
266439
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Rak tyrosine kinase
265586
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receptor interacting protein 3
266451
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receptor-associated kinase JAK2
265442
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receptor-interacting serine/threonine protein kinase 2
Related adhesion focal tyrosine kinase
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Resting lymphocyte kinase
-
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RIP2
266437
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Rlk/Txk
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S-domain receptor-like protein kinase
-
-
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serine/threonine-protein kinase receptor R2
266388
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serine/threonine-protein kinase receptor R3
266381
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SLK
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Spleen tyrosine kinase
Src family kinase
247
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Src kinase
247
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Src protein tyrosine kinase
247
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src protein tyrosine kinase p56Lck
247
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Src protein-tyrosine kinase
247
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Src tyrosine kinase
Src-family protein tyrosine kinase
247
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src-kinase
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SRC-related intestinal kinase
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Srm
247
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Syk kinase
247
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Syk-related tyrosine kinase
-
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SYN
-
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T cell-specific protein-tyrosine kinase
-
-
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T-cell-specific kinase
-
-
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Tec family tyrosine kinase
247
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Tec kinase
247
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TESK1
266430
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TESK2
266434
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testis-specific protein kinase 1
266430
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testis-specific protein kinase 2
266434
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TFK
247
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TGF-beta receptor type I
266378
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TGF-beta receptor type II
266372
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TGF-beta RII
266372
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TGFBR1
266378
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TNK2
298891
gene name
transforming growth factor beta type II receptor
266372
-
transforming growth factor-beta type I receptor 7
266378
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TYK-2
265556
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TYK3
265518
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Tyrosine kinase
-
-
-
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tyrosine kinase 2
265556
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tyrosine kinase Abl
247
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Tyrosine kinase ARG
-
-
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tyrosine kinase c-Src
247
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tyrosine kinase cyl
265575
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Tyrosine kinase lck
-
-
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Tyrosine kinase p56lck
-
-
-
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tyrosine kinase p60c-src
247
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tyrosine kinase PTK6
265661
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tyrosine kinase Src
247
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Tyrosine phosphokinase
-
-
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Tyrosine protein kinase
-
-
-
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Tyrosine protein kinase p56lck
-
-
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tyrosine-protein kinase 6
265661
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tyrosine-protein kinase ABL2
265585
-
tyrosine-protein kinase BLK
265596
-
Tyrosine-protein kinase brk
-
-
-
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tyrosine-protein kinase BTK
265722
-
tyrosine-protein kinase CSK
265575
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Tyrosine-protein kinase CTK
-
-
-
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tyrosine-protein kinase FRK
265586
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tyrosine-protein kinase ITK/TSK
265657
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tyrosine-protein kinase JAK1
265536
-
tyrosine-protein kinase JAK2
265442
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tyrosine-protein kinase JAK3
265599
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Tyrosine-protein kinase Lyk
-
-
-
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tyrosine-protein kinase LYN
265478
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tyrosine-protein kinase SYK
265592
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tyrosine-protein kinase Tec
265581
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tyrosine-protein kinase TXK
265582
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Tyrosine-protein kinase TYRO 10
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-
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tyrosine-protein kinase ZAP-70
265590
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Tyrosine-specific protein kinase
-
-
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Tyrosylprotein kinase
-
-
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v-fps Protein-tyrosine kinase
-
-
-
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WEE1hu
YES related kinase
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-
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YES1
265477
gene name
yrk
247
-
ZAP-70
247
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
phospho group transfer
PATHWAY SOURCE
PATHWAYS