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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Drosophila melanogaster and UniProt Accession P11346
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2.7.10.2 non-specific protein-tyrosine kinaseIUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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- 2.7.10.2
- leukemia
- imatinib
- lymphocytic
- integrins
-
myelogenous
- metastasis
- t-cells
-
cytogenetic
-
philadelphia
- mapks
- lymphoma
- sh2
- cytoskeleton
- erk
- phosphatidylinositol
- lymphoblastic
- adhesions
-
signal-regulated
-
myeloproliferative
- 3-kinase
- autophosphorylation
- paxillin
- dasatinib
- hematologic
- collagen
-
stats
-
remiss
- arthritis
- fibronectin
- neoplasm
-
relapse
-
tyrosine-phosphorylated
- oncoproteins
-
platelet-derived
- pkc
- phosphotyrosine
-
rheumatoid
-
dominant-negative
- adaptor
- mesylate
-
allogeneic
- factor-beta
-
breakpoints
-
integrin-mediated
- cd4
- crisis
- c-kit
-
activins
- drug development
- synthesis
- medicine
- analysis
- pharmacology
- pdgfr
-
kinase-dependent
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
RAF homolog serine/threonine-protein kinase dRAF-1
-
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
focal adhesion kinase 1
-
-
-
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
-
-
-
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
additional information
-
the enzyme belongs to the Janus family of tyrosine kinases
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
enzyme is required in early larval development
-
-
?
ATP + signal transducer and activator of transcription
ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
-
-
-
-
?
ATP + [kinase Btk29]-L-tyrosine
ADP + [kinase Btk29]-L-tyrosine phosphate
-
-
-
-
?
ATP + [ring canal protein]-L-tyrosine
ADP + [ring canal protein]-L-tyrosine phosphate
-
-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
ATP + cdc2
ADP + phosphorylated cdc2
the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
phosphorylation by Jak2 at tyrosine residues
-
-
?
additional information
?
-
in vitro autophosphorylation activity at tyrosine residues
-
-
?
additional information
?
-
-
in vitro autophosphorylation activity at tyrosine residues
-
-
?
additional information
?
-
required maternally for the establishment of the normal array of embryonic segments
-
-
?
additional information
?
-
plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
-
-
?
additional information
?
-
-
plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
-
-
?
additional information
?
-
mutations in the gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS phenotype of armadillo mutations, consistent with these proteins functioning co-operatively at adherens junctions in both the CNS and the epidermis
-
-
?
additional information
?
-
-
Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
-
-
?
additional information
?
-
-
receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
enzyme is required in early larval development
-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis
-
-
?
ATP + [kinase Btk29]-L-tyrosine
ADP + [kinase Btk29]-L-tyrosine phosphate
-
-
-
-
?
ATP + [ring canal protein]-L-tyrosine
ADP + [ring canal protein]-L-tyrosine phosphate
-
-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
-
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
-
-
?
additional information
?
-
required maternally for the establishment of the normal array of embryonic segments
-
-
?
additional information
?
-
plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
-
-
?
additional information
?
-
-
plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling
-
-
?
additional information
?
-
mutations in the gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS phenotype of armadillo mutations, consistent with these proteins functioning co-operatively at adherens junctions in both the CNS and the epidermis
-
-
?
additional information
?
-
-
Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
tyrosine growth factor
-
the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
expression of the enzyme remains high in the proliferating cells of the central nervous system well after cells in the rest of the embryo have ceased dividing
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
enzyme loss causes a reduction in ring canal diameter within germline cysts
physiological function
physiological function
-
JAK-STAT signaling is required for germline stem cell and cyst progenitor cells maintenance in testis
physiological function
-
the enzyme controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KRAF1_DROME
739
0
83729
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
domain structure including catalytic and ligand binding domains, and an activation loop, the domains are termed JH1 to JH7, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
phosphorylation of the activation loop is required for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
E695K
-
mutation in the JH2 domain of the Jak homologue hopscotch, which renders the kinase hyperactive and causes hematopoietic hyperplasia
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Danio rerio (O12990), Danio rerio (O93596), Mus musculus (P00520), Mus musculus (Q9R117), Drosophila melanogaster (P00528), Drosophila melanogaster (P18106), Drosophila melanogaster (Q24145), Drosophila melanogaster (Q9V9J3), Homo sapiens (P06239), Homo sapiens (Q06187), Macaca fascicularis (Q95M30), Rattus norvegicus (Q9WUD9)
Henkemeyer, M.J.; Bennett, R.L.; Gertler, F.B.; Hoffmann, F.M.
DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog
Mol. Cell. Biol.
8
843-853
1988
Drosophila melanogaster (P00522), Drosophila melanogaster
Hoffmann, F.M.; Fresco, L.D.; Hoffman-Falk, H.; Shilo, B.Z.
Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes
Cell
35
393-401
1983
Drosophila melanogaster (P00522)
Loureiro, J.; Peifer, M.
Roles of Armadillo, a Drosophila catenin, during central nervous system development
Curr. Biol.
8
622-632
1998
Drosophila melanogaster (P00522)
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (P54350), Drosophila melanogaster (Q9i7f7)
Oates, A.C.; Wollberg, P.; Achen, M.G.; Wilks, A.F.
Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA
Biochem. Biophys. Res. Commun.
249
660-667
1998
Drosophila melanogaster (Q9i7f7)
Sprenger, F.; Trosclair, M.M.; Morrison, D.K.
Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction
Mol. Cell. Biol.
13
1163-1172
1993
Drosophila melanogaster (P11346)
Ito, M.; Matsui, T.; Taniguchi, T.; Chihara, K.
Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog
Gene
139
215-218
1994
Drosophila melanogaster (Q9i7f7)
Binari, R.; Perrimon, N.
Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila
Genes Dev.
8
300-312
1994
Drosophila melanogaster (Q24592)
Fujimoto, J.; Sawamoto, K.; Okabe, M.; Takagi, Y.; Tezuka, T.; Yoshikawa, S.; Ryo, H.; Okano, H.; Yamamoto, T.
Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster
J. Biol. Chem.
274
29196-29201
1999
Drosophila melanogaster (Q9U5Y2), Drosophila melanogaster
Penton, A.; Chen, Y.; Staehling-Hampton, K.; Wrana, J.L.; Attisano, L.; Szidonya, J.; Cassill, J.A.; Massague, J.; Hoffmann, F.M.
Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
Cell
78
239-250
1994
Drosophila melanogaster (Q27933)
Brummel, T.J.; Twombly, V.; Marques, G.; Wrana, J.L.; Newfeld, S.J.; Attisano, L.; Massague, J.; O'Connor, M.B.; Gelbart, W.M.
Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila
Cell
78
251-261
1994
Drosophila melanogaster (Q27933)
Mark, G.E.; MacIntyre, R.J.; Digan, M.E.; Ambrosio, L.; Perrimon, N.
Drosophila melanogaster homologs of the raf oncogene
Mol. Cell. Biol.
7
2134-2140
1987
Drosophila melanogaster (P11346)
Nishida, Y.; Hata, M.; Ayaki, T.; Ryo, H.; Yamagata, M.; Shimizu, K.; Nishizuka, Y.
Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene
EMBO J.
7
775-781
1988
Drosophila melanogaster (P11346)
Campbell, S.D.; Sprenger, F.; Edgar, B.A.; O'Farrell, P.H.
Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro
Mol. Biol. Cell
6
1333-1347
1995
Drosophila melanogaster (P54350)
Wallace, T.A.; Sayeski, P.P.
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
Cell Biochem. Biophys.
44
213-222
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Issigonis, M.; Tulina, N.; de Cuevas, M.; Brawley, C.; Sandler, L.; Matunis, E.
JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche
Science
326
153-156
2009
Drosophila melanogaster
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