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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Mus musculus and UniProt Accession P05480

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IUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Mus musculus
UNIPROT: P05480
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, v-src, janus kinase, p56lck, ephb4, janus kinase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70 kDa zeta-associated protein
-
-
-
-
A-Raf proto-oncogene serine/threonine-protein kinase
266440
-
Abelson murine leukemia viral homolog (1) protein
244
-
ABL1
244
-
activin receptor type I
266401
-
activin receptor type II
266377
-
activin receptor type IIB
266406
-
ACTR-IIB
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
AKT
244
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BCR/ABL kinase
244
-
Blk
244
-
BMK
-
-
-
-
BMP type II receptor
BMP-2/BMP-4 receptor
-
-
-
-
Bone marrow kinase BMX
-
-
-
-
bone morphogenetic protein receptor type IA
266387
-
bone morphogenetic protein receptor type IB
266390
-
bone morphogenetic protein receptor type II
266382
-
BPK
-
-
-
-
Breast tumor kinase
-
-
-
-
BRK-1
266387
-
Bruton tyrosine kinase
265572
-
Bruton's tyrosine kinase
Brutons tyrosine kinase
244
-
c-ABL
-
-
-
-
c-FER
-
-
-
-
C-FES
-
-
-
-
C-SRC
-
-
-
-
C-SRC kinase
-
-
-
-
C-YES
-
-
-
-
CADTK
-
-
-
-
CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
calcium-dependent tyrosine kinase PYK2
244
-
Cell adhesion kinase beta
-
-
-
-
Csk
244
-
Ctk
265577
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
-
EPS I polysaccharide export protein epsB
-
-
-
-
FAK
244
-
Fer protein-tyrosine kinase
244
-
focal adhesion kinase
265736
-
focal adhesion kinase 1
-
-
-
-
focal adhesion protein tyrosine
244
-
Fps/Fes protein-tyrosine kinase
244
-
Fps/Fes tyrosine kinase
244
-
gene lck protein kinase
-
-
-
-
gene lck tyrosine kinase
-
-
-
-
Hematopoietic consensus tyrosine-lacking kinase
-
-
-
-
Hemopoietic cell kinase
-
-
-
-
IL-2-inducible T-cell kinase
-
-
-
-
integrin-linked protein kinase
266419
-
interleukin-1 receptor-associated kinase 1
266431
-
Itk
-
-
-
-
JAK protein tyrosine kinase
-
-
-
-
Jak-3 Janus kinase
265681
-
Janus kinase
244
-
Janus kinase 1
244
-
Janus kinase 2
just another kinase 2
244
-
Kinase EMB
-
-
-
-
Kinase EMT
-
-
-
-
Kinase TLK
-
-
-
-
kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
-
-
-
-
L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
-
Leukocyte janus kinase
-
-
-
-
LSK
-
-
-
-
lymphocyte-specific protein tyrosine kinase
244
-
Lyn protein tyrosine kinase
244
-
Lyn tyrosine kinase
265542
-
megakaryocyte-associated tyrosine-protein kinase
265577
-
neuronal proto-oncogene tyrosine-protein kinase SRC
265468
-
non-receptor protein tyrosine kinase
244
-
non-receptor tyrosine kinase
244
-
non-receptor tyrosine-protein kinase TYK2
265717
-
nonreceptor protein tyrosine kinase
-
-
-
-
nonreceptor tyrosine kinase
244
-
nonreceptor tyrosine kinase Srm
265683
-
Ntk
265577
-
NTK38
-
-
-
-
Nuclear tyrosine protein kinase RAK
-
-
-
-
ORF6
-
-
-
-
p150
-
-
-
-
p55-BLK
-
-
-
-
P55-FGR
-
-
-
-
p55blk kinase
265517
-
p56-HCK
-
-
-
-
p56-HCK/p59-HCK
-
-
-
-
P56-LCK
-
-
-
-
p56lck
265472
-
p56lck kinase
-
-
-
-
p56lck protein kinase
-
-
-
-
p56lck protein tyrosine kinase
-
-
-
-
p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
-
P60-SRC
-
-
-
-
p60-YRK
-
-
-
-
P61-YES
-
-
-
-
p94-FER
-
-
-
-
phosphotyrosyl-protein kinase
-
-
-
-
PP125FAK
-
-
-
-
pp56lck
265472
-
Protein kinase (tyrosine-phosphorylating)
-
-
-
-
protein kinase A
-
-
-
-
Protein kinase BATK
-
-
-
-
Protein kinase HYL
-
-
-
-
Protein kinase Lck
-
-
-
-
Protein kinase NTK
-
-
-
-
Protein kinase p56-LCK
-
-
-
-
Protein kinase p56lck
-
-
-
-
Protein p56c-lck kinase
-
-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
protein tyrosine kinase PTK70
265683
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
-
proto-oncogene serine/threonine-protein kinase mos
266416
-
proto-oncogene tyrosine-protein kinase ABL1
265447
-
proto-oncogene tyrosine-protein kinase FGR
265506
-
proto-oncogene tyrosine-protein kinase LCK
265472
-
proto-oncogene tyrosine-protein kinase YES
265641
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
-
Raftk
265734
-
receptor interacting protein 3
266450
-
receptor-interacting serine/threonine protein kinase 2
266449
-
receptor-interacting serine/threonine protein kinase 3
266450
-
Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
Rlk
265583
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
-
serine/threonine-protein kinase receptor R3
266385
-
sik
265692
-
SLK
-
-
-
-
Spleen tyrosine kinase
Src family kinase
244
-
Src family tyrosine kinase Lyn
265542
-
Src tyrosine kinase
244
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tec
265539
-
Tec kinase
265539
-
testis-specific protein kinase 1
266422
-
TGF-beta receptor type I
266389
-
TGF-beta receptor type II
266391
-
Tyrosine kinase
-
-
-
-
tyrosine kinase Abl
244
-
Tyrosine kinase ARG
-
-
-
-
tyrosine kinase Csk
244
-
tyrosine kinase Fyn
244
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
tyrosine kinase sf-Stk
244
-
tyrosine kinase Src
244
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
tyrosine-protein kinase 6
265692
-
tyrosine-protein kinase BLK
265517
-
Tyrosine-protein kinase brk
-
-
-
-
tyrosine-protein kinase BTK
265572
-
tyrosine-protein kinase CSK
265576
-
Tyrosine-protein kinase CTK
-
-
-
-
tyrosine-protein kinase HCK
265480
-
tyrosine-protein kinase ITK/TSK
265639
-
tyrosine-protein kinase JAK1
265598
-
tyrosine-protein kinase JAK2
265680
-
tyrosine-protein kinase JAK3
265681
-
Tyrosine-protein kinase Lyk
-
-
-
-
tyrosine-protein kinase LYN
265542
-
tyrosine-protein kinase SRM
265683
-
tyrosine-protein kinase SYK
265594
-
tyrosine-protein kinase Tec
265539
-
tyrosine-protein kinase TXK
265583
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
tyrosine-protein kinase ZAP-70
265591
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
-
v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
yrk
244
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
residue W1038 is essential for catalytic activity
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY hide
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
show the reaction diagram
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
show the reaction diagram
ATP + Bad protein
ADP + phosphotyrosinyl Bad protein
show the reaction diagram
-
substrate of Akt
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
show the reaction diagram
-
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
show the reaction diagram
-
-
-
-
?
ATP + Cbp
? + ADP
show the reaction diagram
-
murine Csk binding protein, Cbp, amino acids 74-474, substrate used in kinase activity assay
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
show the reaction diagram
-
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
show the reaction diagram
-
-
-
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
show the reaction diagram
-
-
-
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
show the reaction diagram
-
substrate of Akt
-
-
?
ATP + KVEKIGEGTYGVVYK
? + ADP
show the reaction diagram
-
substrate peptide used in kinase activity assay, derived from p34cdc2
-
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
show the reaction diagram
-
-
-
-
?
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
show the reaction diagram
-
-
-
-
?
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
show the reaction diagram
-
-
-
-
?
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
show the reaction diagram
-
-
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
show the reaction diagram
-
-
-
-
?
ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
show the reaction diagram
-
-
-
-
?
ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
show the reaction diagram
-
-
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
show the reaction diagram
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine
ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
show the reaction diagram
-
substrate HCN4, tyrosine 531 is phosphorylated
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
O70146
role for this kinase in spermatogenesis
-
-
-
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
ATP + Abl
ADP + phospho-L-tyrosinyl-Abl
show the reaction diagram
-
Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview
-
-
?
ATP + Akt tyrosine kinase
ADP + phosphotyrosinyl-Akt
show the reaction diagram
-
tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview
-
-
?
ATP + Bad protein
ADP + phosphotyrosinyl Bad protein
show the reaction diagram
-
substrate of Akt
-
-
?
ATP + beta-catenin
ADP + phospho-tyrosinyl-beta-catenin
show the reaction diagram
-
-
-
-
?
ATP + Cas protein
ADP + phospho-tyrosinyl-Cas protein
show the reaction diagram
-
-
-
-
?
ATP + cortactin
ADP + phospho-tyrosinyl-cortactin
show the reaction diagram
-
-
-
-
?
ATP + ezrin
ADP + phospho-tyrosinyl-ezrin
show the reaction diagram
-
-
-
-
?
ATP + FAK
ADP + phospho-tyrosinyl-FAK
show the reaction diagram
-
-
-
-
?
ATP + glycogen synthase kinase 3beta
ADP + phosphotyrosinyl glycogen synthase kinase 3beta
show the reaction diagram
-
substrate of Akt
-
-
?
ATP + p120 protein
ADP + phospho-tyrosinyl-p120 protein
show the reaction diagram
-
-
-
-
?
ATP + p190 GTPase
ADP + phospho-tyrosinyl-p190 GTPase
show the reaction diagram
-
-
-
-
?
ATP + paxillin
ADP + phospho-tyrosinyl-Shc paxillin
show the reaction diagram
-
-
-
-
?
ATP + plakoglobin
ADP + phospho-tyrosinyl-plakoglobin
show the reaction diagram
-
-
-
-
?
ATP + Rho protein
ADP + phospho-tyrosinyl-Rho protein
show the reaction diagram
-
-
-
-
?
ATP + Shc protein
ADP + phospho-tyrosinyl-Shc protein
show the reaction diagram
-
-
-
-
?
ATP + STAT3
ADP + phospho-tyrosinyl-STAT3
show the reaction diagram
-
-
-
-
?
ATP + [disabled-1 adaptor protein]-L-tyrosine
ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
show the reaction diagram
-
activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview
-
-
?
ATP + [protein]-L-tyrosine
ADP + [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
STAT transcription activator protein + ATP
phosphorylated STAT transcription activator protein + ADP
show the reaction diagram
-
activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
dependent on, PYK2 is involved in Ca2+ mobilization in muscle cells
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
-
indirect pharmacological inhibitor
4-(2-fluoro-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
-
4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
-
-
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
-
-
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(isopropylamino)-9H-carbazole-1-carboxamide
-
-
4-(3-(5-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
-
4-(3-(5-fluoropicolinamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
-
-
4-(3-(6-fluoro-1-oxoisoindolin-2-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
-
4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
-
4-(3-(7-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
-
4-(3-(8-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
-
-
4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo[3,4-d]pyrimidine
-
-
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine
-
-
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
-
-
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-9H-carbazole-1-carboxamide
-
-
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
-
-
7-(2-hydroxypropan-2-yl)-4-(3-(4-oxoquinazolin-3(4H)-yl)-phenyl)-9H-carbazole-1-carboxamide
-
-
7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide
-
BMS-935177
7-(hydroxymethyl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-9H-carbazole-1-carboxamide
-
-
A-419259
-
high inhibition of SFKs
-
AMP-PNP
-
-
AZD-1480
-
Jak2 inhibitor
AZM 475271
-
-
bosutinib
-
previously SKI-606, inhibits ABL1
CGP 76030
-
-
CGP 77675
-
-
CP-690 550
-
Jak3 and Jak2 inhibitor
CP-690,550
-
has nanomolar potency in in vitro JAK2 and JAK3 kinase assays
curcumin
-
downregulates and inhibits tyrosine kinase Syk, which leads to inhibition of Akt, in lymphoma cells, curcumin causes growth inhibition of B lymphoma, mechanism, overview
dasatinib
geldanamycin
-
indirect pharmacological inhibitor
Gleevec
-
also known as STI-571 or imatinib
ibrutinib
-
-
imatinib
INCB018424
-
Jak2 inhibitor
INCB18424
-
Incyte
INNO-406
-
previously NS-187, inhibits ABL1
interferon-gamma
-
enzyme inhibition in leukemic bone marrow cells
-
ITF2357
-
Jak2 inhibitor
lestaurtinib
LFM-A13
LS104
-
Jak2 inhibitor
M 475271
-
-
MK-0457
-
Jak2 inhibitor
nilotinib
-
potent ABL1 inhibitor
PC-005
-
-
-
PCI-31523
-
-
peroxiredoxin 1
-
inhibits ABL1 intracellularly
-
piceatannol
PIP2
-
inhibits ABL1 intracellularly
PNU156804
-
Jak3 inhibitor
SB1518
-
Jak2 inhibitor
shRNA
-
-
-
siRNA
-
-
-
SKI-606
-
-
Src kinase inhibitor-1
-
i.e. SKI-1, a 4-anilinoquinazoline, moderate inhibition in vitro and vivo
-
SU-6656
-
-
SU6656
TG101209
-
Jak2 inhibitor
TG101348
-
Jak2 inhibitor
tyrphostin AG490
-
Jak3 inhibitor
WHI-P131
-
Jak3 inhibitor
WHI-P154
-
Jak3 inhibitor
XL019
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CX3CL1
-
i.e. fractalkine, only member of the delta subclass of chemokines, induces Syk activity in cytoskeletal remodeling
-
cytokine receptors
-
-
-
erythropoietin
-
activates Fps/Fes tyrosine kinase
-
interleukin-2
-
enzyme activation in leukemic bone marrow cells
-
N,N'-ethylnitrosourea
-
enzyme activation in leukemic bone marrow cells
non-specific BRM sheep erythrocyte
-
BRM is biological response modifier, treatment leads to a slight enzyme activation in leukemic bone marrow cells
-
Reelin
-
extracellular, stimulates disabled-1 adaptor protein Dab1 tyrosine phosphorylation by Src family PTKs, downregulates Dab1 expression in vivo
-
stem cell factor SCF
-
activates Fps/Fes tyrosine kinase
-
tyrosine growth factor
-
the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors
-
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000004
4-(2-fluoro-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000005
4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000005
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000011
4-(3-(4-fluorobenzamido)-2-methylphenyl)-7-(isopropylamino)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000005
4-(3-(5-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000009
4-(3-(5-fluoropicolinamido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000002
4-(3-(6-fluoro-1-oxoisoindolin-2-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000007
4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000002
4-(3-(7-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000002
4-(3-(8-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000009
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
Mus musculus
-
substrate Csk binding protein, Cbp
0.000003
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000005
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000005
7-(2-hydroxypropan-2-yl)-4-(2-methyl-3-(1-oxoisoquinolin-2(1H)-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000044
7-(2-hydroxypropan-2-yl)-4-(3-(4-oxoquinazolin-3(4H)-yl)-phenyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000003
7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000003
7-(hydroxymethyl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-9H-carbazole-1-carboxamide
Mus musculus
-
at pH 7.4 and 22°C
0.000011
dasatinib
Mus musculus
-
substrate Csk binding protein, Cbp
0.0000172
LFM-A13
Mus musculus
-
-
0.000035
SU6656
Mus musculus
-
substrate Csk binding protein, Cbp
additional information
additional information
Mus musculus
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2
-
in vitro c-Src kinase activity assay
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
-
assay at room temperature
30
-
kinase assay
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
lining of the alimentary canal
Manually annotated by BRENDA team
-
endothelial cells, PYK2
Manually annotated by BRENDA team
-
upregulated expression of syk is observed in aggressive, metastasizing mammary gland tumours but not in well differentiated, non-metastasizing tumors
Manually annotated by BRENDA team
expressed only in epithelial tissues, including the skin and lining of the alimentary canal
Manually annotated by BRENDA team
-
peripheral, in bone marrow and spleen, Fps/Fes tyrosine kinase expression in early erythroid progenitors/blasts and in mature red cells
Manually annotated by BRENDA team
-
ES cell D3 line, embryonic stem cell, expression of 7 different Src family kinases, 3 are involved in differentiation to embryoid bodies
Manually annotated by BRENDA team
-
retinal ganglion cell layer and the inner part of the inner nuclear layer. During retinal development, JAK1 protein is first detected in retinal ganglion cells and in their axons as early as embryonic day 14. Expression of JAK1 protein in amacrine cells and horizontal cells occurrs only postnatally
Manually annotated by BRENDA team
-
faintly
Manually annotated by BRENDA team
-
HL-1 cardiomyocyte
Manually annotated by BRENDA team
intestinal crypt cells
Manually annotated by BRENDA team
-
spinal microglia
Manually annotated by BRENDA team
-
faintly
Manually annotated by BRENDA team
-
derived from monocyte/macrophage cell line RAW 264.7
Manually annotated by BRENDA team
-
adult CD4-CD8-thymocytes
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
SRC_MOUSE
541
0
60645
Swiss-Prot
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
53000
-
alternative splicing variant, identified by SDS-PAGE and Western blot analysis
56000
-
identified by SDS-PAGE and Western blot analysis
60000
-
determined by SDS-PAGE and Western Blot analysis
60630
-
calculation from nucleotide sequence
75000
-
x * 75000, about, Syk, SDS-PAGE
87000
-
x * 87000, SDS-PAGE
130000
-
approximately
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetylation
-
normal activation of the ABL1 proteins requires acetylation
acylation
-
normal activation of the ABL1 proteins requires myristoylation
phosphoprotein
side-chain modification
additional information
CRYSTALLIZATION/commentary
ORGANISM
UNIPROT
LITERATURE
crystal structure of the extracellular ligand-binding domain of the type II activin receptor
-
determination of the three-dimensional solution structure of the SH2 domain of blk kinase by nuclear magnetic resonance NMR spectroscopy
-
hanging drop vapor diffusion method, using 31% (w/v) methyl ether PEG 5000, 1% (w/v) PEG 8000, 0.2 M Tris-HCl, pH 8.5
-
high-resolution crystal structures of the complexes between the SH3 domains of Abl and Fyn tyrosine kinases, and two ten-residue proline-rich peptides derived from the SH3-binding proteins 3BP-1 and 3BP-2
-
in complex with gleevec
-
the crystal structures of the kinase domain of Lyn are determined in complex with three different inhibitors, AMP-PNP, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine and dasatinib, as well as the non-liganded form of the enzyme, at 2.5 to 2.7 A resolution
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K273R
-
mutant protein is unable to transfer the gamma-phosphate of ATP but able to bind 8-azido-ATP with an efficiency similar to that of wild-type pp56lck
V617F
W1038G/E1046A
site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview
W1038G/E1046R
site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview
additional information
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared
-
using nickel-chelating resin, a HiTrap Q column and gel filtration
-
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
isolation of a c-src cDNA clone
; maps to the distal end of chromosome 2
-
application of the polymerase chain reaction to cloning
-
expression in COS cells
-
expression in Escherichia coli
expression of Abl in NIH 3T3 cells and in HEK-293 cells
-
expression of SFKs Hck, Fyn, Lck, and Yes in human 293T cells, expression of N-terminally His-tagged Hck in Spodoptera frugiperda Sf9 cells via baculovirus infection system
-
four new activin receptor isoforms
genetic analysis of mutations causing cell cycle deregulation, e.g. in mice lacking cyclin-D2, heterozygous D2+/- mice are resistant to BCR/ABL-induced proliferation, overview
-
isolation and structural analysis of murine c-fes cDNA clones
-
isolation of cDNA
-
Jak2, DNA and amino acid sequence determination and analysis, oc-expression of wild-type Jak2 with increasing amounts of mutant W1038G/E1024A or mutant W1038G/E1024R, the latter is more potent in reducing wild-type enzyme actiivty in a dominant-negative way, overview
lskT gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
-
retroviral expression in 293T cells prior to infection of RAW cells for stable Syk expression
-
Tec gene consists of 18 exons and spans more than 86 kb
-
Tec gene is tightly linked to the c-Kit gene on chromosome 5
-
testis-specific c-abl mRNAs arise as a result of 3' truncation. The v-abl gene has arisen from its cellular homologue as a result of an extensive deletional/mutational process
-
the murine Lyn kinase domain, amino acids 239-512, is subcloned into the baculovirus expression vector pFastBacHTA generating a His6-tagged fusion resulting in a 5 amino acid N-terminal extension to the Lyn kinase domain after tobacco etch virus cleavage
-
the retroviral vector pMX-Tec-IRES-GFP is constructed
-
the retroviral vectors pMX-Btk-IRES-GFP, pMX-Btk(R28C)-IRES-GFP and pMX-Btk(R525Q)-IRES-GFP are constructed
-
two isoforms of murine hck, generated by utilization of alternative translational initiation codons
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
isoform Btk expression is up-regulated during maturation and activation of mouse natural killer cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
pharmacology
-
the enzyme is a pharmaceutical target for inhibitors in therapy of acute inflammatory responses, e.g. acute lung injury, ischemic brain injury, brain injury, spinal cord compression, stroke, and myocardial infarction, detailed overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Danio rerio (O12990), Danio rerio (O93596), Drosophila melanogaster (P00528), Drosophila melanogaster (P18106), Drosophila melanogaster (Q24145), Drosophila melanogaster (Q9V9J3), Homo sapiens (P06239), Homo sapiens (Q06187), Macaca fascicularis (Q95M30), Mus musculus (P00520), Mus musculus (Q9R117), Rattus norvegicus (Q9WUD9)
Manually annotated by BRENDA team
Chissoe, S.L.; Bodenteich, A.; Wang, Y.F.; Wang, Y.P.; Burian, D.; Clifton, S.W.; Crabtree, J.; Freeman, A.; Iyer, K.; Jian, L.; et al.
Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation
Genomics
27
67-82
1995
Homo sapiens (P00519), Mus musculus (P00520)
Manually annotated by BRENDA team
Bernards, A.; Paskind, M.; Baltimore, D.
Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing
Oncogene
2
297-304
1988
Mus musculus, Mus musculus (P00520)
Manually annotated by BRENDA team
Musacchio, A.; Saraste, M.; Wilmanns, M.
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides
Nat. Struct. Biol.
1
546-551
1994
Homo sapiens (P06241), Mus musculus (P00520)
Manually annotated by BRENDA team
Oppi, C.; Shore, S.K.; Reddy, E.P.
Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation
Proc. Natl. Acad. Sci. USA
84
8200-8204
1987
Mus musculus, Mus musculus (P00520)
Manually annotated by BRENDA team
Wang, J.Y.; Ledley, F.; Goff, S.; Lee, R.; Groner, Y.; Baltimore, D.
The mouse c-abl locus: molecular cloning and characterization
Cell
36
349-356
1984
Mus musculus, Mus musculus (P00520)
Manually annotated by BRENDA team
Martinez, R.; Mathey-Prevot, B.; Bernards, A.; Baltimore, D.
Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart
Science
237
411-415
1987
Mus musculus (P05480)
Manually annotated by BRENDA team
Abraham, K.M.; Levin, S.D.; Marth, J.D.; Forbush, K.A.; Perlmutter, R.M.
Thymic tumorigenesis induced by overexpression of p56lck
Proc. Natl. Acad. Sci. USA
88
3977-3981
1991
Mus musculus, Mus musculus (P06240)
Manually annotated by BRENDA team
Abraham, N.; Miceli, M.C.; Parnes, J.R.; Veillette, A.
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck
Nature
350
62-66
1991
Mus musculus, Mus musculus (P06240)
Manually annotated by BRENDA team
Benavente, J.; Shatkin, A.J.
Avian reovirus mRNAs are nonfunctional in infected mouse cells: translational basis for virus host-range restriction
Proc. Natl. Acad. Sci. USA
85
4257-4261
1988
Mus musculus (P06240)
Manually annotated by BRENDA team
Carrera, A.C.; Alexandrov, K.; Roberts, T.M.
The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP
Proc. Natl. Acad. Sci. USA
90
442-446
1993
Mus musculus (P06240)
Manually annotated by BRENDA team
Garvin, A.M.; Pawar, S.; Marth, J.D.; Perlmutter, R.M.
Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line
Mol. Cell. Biol.
8
3058-3064
1988
Mus musculus, Mus musculus (P06240)
Manually annotated by BRENDA team
Hurley, T.R.; Amrein, K.E.; Sefton, B.M.
Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase
J. Virol.
66
7406-7413
1992
Mus musculus (P06240)
Manually annotated by BRENDA team
Koegl, M.; Zlatkine, P.; Ley, S.C.; Courtneidge, S.A.; Magee, A.I.
Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif
Biochem. J.
303
749-753
1994
Mus musculus (P06240)
Manually annotated by BRENDA team
Marth, J.D.; Peet, R.; Krebs, E.G.; Perlmutter, R.M.
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
Cell
43
393-404
1985
Mus musculus, Mus musculus (P06240)
Manually annotated by BRENDA team
Shenoy-Scaria, A.M.; Gauen, L.K.; Kwong, J.; Shaw, A.S.; Lublin, D.M.
Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins
Mol. Cell. Biol.
13
6385-6392
1993
Mus musculus (P06240)
Manually annotated by BRENDA team
Voronova, A.F.; Adler, H.T.; Sefton, B.M.
Two lck transcripts containing different 5' untranslated regions are present in T cells
Mol. Cell. Biol.
7
4407-4413
1987
Mus musculus, Mus musculus (P06240)
Manually annotated by BRENDA team
Voronova, A.F.; Sefton, B.M.
Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion
Nature
319
682-685
1986
Mus musculus, Mus musculus (P06240)
Manually annotated by BRENDA team
Holtzman, D.A.; Cook, W.D.; Dunn, A.R.
Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells
Proc. Natl. Acad. Sci. USA
84
8325-8329
1987
Mus musculus (P08103)
Manually annotated by BRENDA team
Klemsz, M.J.; McKercher, S.R.; Maki, R.A.
Nucleotide sequence of the mouse hck gene
Nucleic Acids Res.
15
9600
1987
Mus musculus (P08103)
Manually annotated by BRENDA team
Lock, P.; Ralph, S.; Stanley, E.; Boulet, I.; Ramsay, R.; Dunn, A.R.
Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization
Mol. Cell. Biol.
11
4363-4370
1991
Homo sapiens (P08631), Mus musculus (P08103)
Manually annotated by BRENDA team
King, F.J.; Cole, M.D.
Molecular cloning and sequencing of the murine c-fgr gene
Oncogene
5
337-344
1990
Mus musculus (P14234)
Manually annotated by BRENDA team
Yi, T.L.; Willman, C.L.
Cloning of the murine c-fgr proto-oncogene cDNA and induction of c-fgr expression by proliferation and activation factors in normal bone marrow-derived monocytic cells
Oncogene
4
1081-1087
1989
Mus musculus, Mus musculus (P14234)
Manually annotated by BRENDA team
Wilks, A.F.; Kurban, R.R.; Hovens, C.M.; Ralph, S.J.
The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family
Gene
85
67-74
1989
Mus musculus (P16879), Mus musculus (P24604), Mus musculus (P25911), Mus musculus (P52332), Mus musculus (Q62120)
Manually annotated by BRENDA team
Dymecki, S.M.; Niederhuber, J.E.; Desiderio, S.V.
Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells
Science
247
332-336
1990
Mus musculus, Mus musculus (P16277)
Manually annotated by BRENDA team
Metzler, W.J.; Leiting, B.; Pryor, K.; Mueller, L.; Farmer, B.T.
The three-dimensional solution structure of the SH2 domain from p55blk kinase
Biochemistry
35
6201-6211
1996
Mus musculus (P16277)
Manually annotated by BRENDA team
Wilks, A.F.; Kurban, R.R.
Isolation and structural analysis of murine c-fes cDNA clones
Oncogene
3
289-294
1988
Mus musculus, Mus musculus (P16879)
Manually annotated by BRENDA team
Mano, H.; Ishikawa, F.; Nishida, J.; Hirai, H.; Takaku, F.
A novel protein-tyrosine kinase, tec, is preferentially expressed in liver
Oncogene
5
1781-1786
1990
Mus musculus, Mus musculus (P24604)
Manually annotated by BRENDA team
Mano, H.; Mano, K.; Tang, B.; Koehler, M.; Yi, T.; Gilbert, D.J.; Jenkins, N.A.; Copeland, N.G.; Ihle, J.N.
Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit
Oncogene
8
417-424
1993
Mus musculus, Mus musculus (P24604)
Manually annotated by BRENDA team
Merkel, A.L.; Atmosukarto, II; Stevens, K.; Rathjen, P.D.; Booker, G.W.
Splice variants of the mouse Tec gene are differentially expressed in vivo
Cytogenet. Cell Genet.
84
132-139
1999
Mus musculus, Mus musculus (P24604)
Manually annotated by BRENDA team
Stanley, E.; Ralph, S.; McEwen, S.; Boulet, I.; Holtzman, D.A.; Lock, P.; Dunn, A.R.
Alternatively spliced murine lyn mRNAs encode distinct proteins
Mol. Cell. Biol.
11
3399-3406
1991
Mus musculus (P25911)
Manually annotated by BRENDA team
Yi, T.L.; Bolen, J.B.; Ihle, J.N.
Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus
Mol. Cell. Biol.
11
2391-2398
1991
Mus musculus, Mus musculus (P25911)
Manually annotated by BRENDA team
Oeltjen, J.C.; Liu, X.; Lu, J.; Allen, R.C.; Muzny, D.; Belmont, J.W.; Gibbs, R.A.
Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci
Mamm. Genome
6
334-338
1995
Mus musculus (P35991)
Manually annotated by BRENDA team
Rawlings, D.J.; Saffran, D.C.; Tsukada, S.; Largaespada, D.A.; Grimaldi, J.C.; Cohen, L.; Mohr, R.N.; Bazan, J.F.; Howard, M.; Copeland, N.G.; et al.
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
Science
261
358-361
1993
Mus musculus, Mus musculus (P35991)
Manually annotated by BRENDA team
Sideras, P.; Muller, S.; Shiels, H.; Jin, H.; Khan, W.N.; Nilsson, L.; Parkinson, E.; Thomas, J.D.; Branden, L.; Larsson, I.; et al.
Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci
J. Immunol.
153
5607-5617
1994
Mus musculus, Mus musculus (P35991)
Manually annotated by BRENDA team
Tsukada, S.; Saffran, D.C.; Rawlings, D.J.; Parolini, O.; Allen, R.C.; Klisak, I.; Sparkes, R.S.; Kubagawa, H.; Mohandas, T.; Quan, S.; et al.
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
Cell
72
279-290
1993
Mus musculus (P35991)
Manually annotated by BRENDA team
Yamada, N.; Kawakami, Y.; Kimura, H.; Fukamachi, H.; Baier, G.; Altman, A.; Kato, T.; Inagaki, Y.; Kawakami, T.
Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells
Biochem. Biophys. Res. Commun.
192
231-240
1993
Mus musculus (P35991), Mus musculus (Q03526)
Manually annotated by BRENDA team
Gilardi-Hebenstreit, P.; Nieto, M.A.; Frain, M.; Mattei, M.G.; Chestier, A.; Wilkinson, D.G.; Charnay, P.
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
Oncogene
7
2499-2506
1992
Mus musculus (P41241)
Manually annotated by BRENDA team
Klages, S.; Adam, D.; Class, K.; Fargnoli, J.; Bolen, J.B.; Penhallow, R.C.
Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family
Proc. Natl. Acad. Sci. USA
91
2597-2601
1994
Mus musculus, Mus musculus (P41241), Mus musculus (P41242)
Manually annotated by BRENDA team
Chow, L.M.; Jarvis, C.; Hu, Q.; Nye, S.H.; Gervais, F.G.; Veillette, A.; Matis, L.A.
Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes
Proc. Natl. Acad. Sci. USA
91
4975-4979
1994
Mus musculus (P41242)
Manually annotated by BRENDA team
Kaneko, Y.; Nonoguchi, K.; Fukuyama, H.; Takano, S.; Higashitsuji, H.; Nishiyama, H.; Takenawa, J.; Nakayama, H.; Fujita, J.
Presence of alternative 5' untranslated sequences and identification of cells expressing ctk transcripts in the brain and testis
Oncogene
10
945-952
1995
Mus musculus (P41242)
Manually annotated by BRENDA team
Haire, R.N.; Litman, G.W.
The murine form of TXK, a novel TEC kinase expressed in thymus maps to chromosome 5
Mamm. Genome
6
476-480
1995
Mus musculus, Mus musculus (P42682)
Manually annotated by BRENDA team
Hu, Q.; Davidson, D.; Schwartzberg, P.L.; Macchiarini, F.; Lenardo, M.J.; Bluestone, J.A.; Matis, L.A.
Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage
J. Biol. Chem.
270
1928-1934
1995
Mus musculus (P42682)
Manually annotated by BRENDA team
Gauen, L.K.; Zhu, Y.; Letourneur, F.; Hu, Q.; Bolen, J.B.; Matis, L.A.; Klausner, R.D.; Shaw, A.S.
Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif
Mol. Cell. Biol.
14
3729-3741
1994
Mus musculus (P43404)
Manually annotated by BRENDA team
Fluck, M.; Zurcher, G.; Andres, A.C.; Ziemiecki, A.
Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein
Biochem. Biophys. Res. Commun.
213
273-281
1995
Mus musculus (P48025)
Manually annotated by BRENDA team
Turner, M.; Mee, P.J.; Costello, P.S.; Williams, O.; Price, A.A.; Duddy, L.P.; Furlong, M.T.; Geahlen, R.L.; Tybulewicz, V.L.
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
Nature
378
298-302
1995
Mus musculus (P48025)
Manually annotated by BRENDA team
Wilks, A.F.
Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction
Proc. Natl. Acad. Sci. USA
86
1603-1607
1989
Mus musculus (P52332), Mus musculus (Q62120)
Manually annotated by BRENDA team
Yang, X.; Chung, D.; Cepko, C.L.
Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system
J. Neurosci.
13
3006-3017
1993
Mus musculus, Mus musculus (P52332)
Manually annotated by BRENDA team
Hebert, B.; Bergeron, J.; Tijssen, P.; Potworowski, E.F.
Protein tyrosine kinases transcribed in a murine thymic medullary epithelial cell line
Gene
143
257-260
1994
Mus musculus (Q04736)
Manually annotated by BRENDA team
Klages, S.; Adam, D.; Eiseman, E.; Fargnoli, J.; Dymecki, S.M.; Desiderio, S.V.; Bolen, J.B.
Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase
Oncogene
8
713-719
1993
Mus musculus, Mus musculus (Q04736)
Manually annotated by BRENDA team
Silvennoinen, O.; Witthuhn, B.A.; Quelle, F.W.; Cleveland, J.L.; Yi, T.; Ihle, J.N.
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
Proc. Natl. Acad. Sci. USA
90
8429-8433
1993
Mus musculus, Mus musculus (Q62120)
Manually annotated by BRENDA team
Gurniak, C.B.; Berg, L.J.
Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells
Blood
87
3151-3160
1996
Mus musculus (Q62137)
Manually annotated by BRENDA team
Rane, S.G.; Reddy, E.P.
JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells
Oncogene
9
2415-2423
1994
Mus musculus (Q62137)
Manually annotated by BRENDA team
Witthuhn, B.A.; Silvennoinen, O.; Miura, O.; Lai, K.S.; Cwik, C.; Liu, E.T.; Ihle, J.N.
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
Nature
370
153-157
1994
Mus musculus (Q62137)
Manually annotated by BRENDA team
Kawachi, Y.; Nakauchi, H.; Otsuka, F.
Isolation of a cDNA encoding a tyrosine kinase expressed in murine skin
Exp. Dermatol.
6
140-146
1997
Mus musculus, Mus musculus (Q62270)
Manually annotated by BRENDA team
Kohmura, N.; Yagi, T.; Tomooka, Y.; Oyanagi, M.; Kominami, R.; Takeda, N.; Chiba, J.; Ikawa, Y.; Aizawa, S.
A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption
Mol. Cell. Biol.
14
6915-6925
1994
Mus musculus (Q62270)
Manually annotated by BRENDA team
Vasioukhin, V.; Serfas, M.S.; Siyanova, E.Y.; Polonskaia, M.; Costigan, V.J.; Liu, B.; Thomason, A.; Tyner, A.L.
A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract
Oncogene
10
349-357
1995
Mus musculus, Mus musculus (Q64434)
Manually annotated by BRENDA team
Benzing, T.; Gerke, P.; Hopker, K.; Hildebrandt, F.; Kim, E.; Walz, G.
Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2
Proc. Natl. Acad. Sci. USA
98
9784-9789
2001
Mus musculus (Q9QVP9)
Manually annotated by BRENDA team
Burgaya, F.; Toutant, M.; Studler, J.M.; Costa, A.; Le Bert, M.; Gelman, M.; Girault, J.A.
Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity
J. Biol. Chem.
272
28720-28725
1997
Mus musculus (P34152)
Manually annotated by BRENDA team
Avraham, S.; London, R.; Fu, Y.; Ota, S.; Hiregowdara, D.; Li, J.; Jiang, S.; Pasztor, L.M.; White, R.A.; Groopman, J.E.; et al.
Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain
J. Biol. Chem.
270
27742-27751
1995
Mus musculus, Mus musculus (Q9QVP9)
Manually annotated by BRENDA team
Hanks, S.K.; Calab, M.B.; Harper, M.C.; Patel, S.K.
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin
Proc. Natl. Acad. Sci. USA
89
8487-8491
1992
Mus musculus, Mus musculus (P34152)
Manually annotated by BRENDA team
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (P04627), Mus musculus (P47810)
Manually annotated by BRENDA team
Greenwald, J.; Fischer, W.H.; Vale, W.W.; Choe, S.
Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase
Nat. Struct. Biol.
6
18-22
1999
Mus musculus (P27038)
Manually annotated by BRENDA team
Beppu, H.; Minowa, O.; Miyazono, K.; Kawabata, M.
cDNA cloning and genomic organization of the mouse BMP type II receptor
Biochem. Biophys. Res. Commun.
235
499-504
1997
Mus musculus, Mus musculus (O35607)
Manually annotated by BRENDA team
Wu, X.; Robinson, C.E.; Fong, H.W.; Crabtree, J.S.; Rodriguez, B.R.; Roe, B.A.; Gimble, J.M.
Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog
Biochem. Biophys. Res. Commun.
216
78-83
1995
Mus musculus (Q61288)
Manually annotated by BRENDA team
Dewulf, N.; Verschueren, K.; Lonnoy, O.; Moren, A.; Grimsby, S.; Vande Spiegle, K.; Miyazono, K.; Huylebroeck, D.; Ten Dijke, P.
Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
Endocrinology
136
2652-2663
1995
Mus musculus (P36895), Mus musculus (Q61288)
Manually annotated by BRENDA team
Tomoda, T.; Kudoh, T.; Noma, T.; Nakazawa, A.; Muramatsu, M.; Arai, K.
Molecular cloning of a mouse counterpart for human TGF-beta type I receptor
Biochem. Biophys. Res. Commun.
198
1054-1062
1994
Mus musculus (Q64729)
Manually annotated by BRENDA team
ten Dijke, P.; Yamashita, H.; Ichijo, H.; Franzen, P.; Laiho, M.; Miyazono, K.; Heldin, C.H.
Characterization of type I receptors for transforming growth factor-beta and activin
Science
264
101-104
1994
Mus musculus (P36898)
Manually annotated by BRENDA team
Suzuki, A.; Shioda, N.; Maeda, T.; Tada, M.; Ueno, N.
Cloning of an isoform of mouse TGF-beta type II receptor gene
FEBS Lett.
355
19-22
1994
Mus musculus, Mus musculus (Q62312)
Manually annotated by BRENDA team
Suzuki, A.; Thies, R.S.; Yamaji, N.; Song, J.J.; Wozney, J.M.; Murakami, K.; Ueno, N.
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
Proc. Natl. Acad. Sci. USA
91
10255-10259
1994
Mus musculus (P36895)
Manually annotated by BRENDA team
Suzuki, A.; Shioda, N.; Maeda, T.; Tada, M.; Ueno, N.
A mouse TGF-beta type I receptor that requires type II receptor for ligand binding
Biochem. Biophys. Res. Commun.
198
1063-1069
1994
Mus musculus, Mus musculus (Q64729)
Manually annotated by BRENDA team
Lawler, S.; Candia, A.F.; Ebner, R.; Shum, L.; Lopez, A.R.; Moses, H.L.; Wright, C.V.; Derynck, R.
The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1
Development
120
165-175
1994
Mus musculus (Q62312)
Manually annotated by BRENDA team
Koenig, B.B.; Cook, J.S.; Wolsing, D.H.; Ting, J.; Tiesman, J.P.; Correa, P.E.; Olson, C.A.; Pecquet, A.L.; Ventura, F.; Grant, R.A.; et, a.
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells
Mol. Cell. Biol.
14
5961-5974
1994
Mus musculus, Mus musculus (P36895)
Manually annotated by BRENDA team
ten Dijke, P.; Ichijo, H.; Franzen, P.; Schulz, P.; Saras, J.; Toyoshima, H.; Heldin, C.H.; Miyazono, K.
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity
Oncogene
8
2879-2887
1993
Homo sapiens (P36894), Homo sapiens (P37023), Homo sapiens (Q04771), Mus musculus (P36898)
Manually annotated by BRENDA team
Ebner, R.; Chen, R.H.; Shum, L.; Lawler, S.; Zioncheck, T.F.; Lee, A.; Lopez, A.R.; Derynck, R.
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor
Science
260
1344-1348
1993
Mus musculus (P37172)
Manually annotated by BRENDA team
Attisano, L.; Wrana, J.L.; Cheifetz, S.; Massague, J.
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
Cell
68
97-108
1992
Mus musculus (P27040)
Manually annotated by BRENDA team
Mathews, L.S.; Vale, W.W.
Expression cloning of an activin receptor, a predicted transmembrane serine kinase
Cell
65
973-982
1991
Mus musculus (P27038)
Manually annotated by BRENDA team
Rechavi, G.; Givol, D.; Canaani, E.
Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element
Nature
300
607-611
1982
Mus musculus (P00536)
Manually annotated by BRENDA team
Van Beveren, C.; van Straaten, F.; Galleshaw, J.A.; Verma, I.M.
Nucleotide sequence of the genome of a murine sarcoma virus
Cell
27
97-108
1981
Moloney murine sarcoma virus (P00538), Mus musculus (P00536)
Manually annotated by BRENDA team
Li, F.; Liu, J.; Mayne, R.; Wu, C.
Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase
Biochim. Biophys. Acta
1358
215-220
1997
Homo sapiens (Q13418), Mus musculus (O55222)
Manually annotated by BRENDA team
Toshima, J.; Nakagawara, K.; Mori, M.; Noda, T.; Mizuno, K.
Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene
Gene
206
237-245
1998
Mus musculus, Mus musculus (O70146)
Manually annotated by BRENDA team
Trofimova, M.; Sprenkle, A.B.; Green, M.; Sturgill, T.W.; Goebl, M.G.; Harrington, M.A.
Developmental and tissue-specific expression of mouse pelle-like protein kinase
J. Biol. Chem.
271
17609-17612
1996
Mus musculus (Q62406)
Manually annotated by BRENDA team
Stanger, B.Z.; Leder, P.; Lee, T.H.; Kim, E.; Seed, B.
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
Cell
81
513-523
1995
Homo sapiens (Q13546), Mus musculus (Q60855)
Manually annotated by BRENDA team
Pazdernik, N.J.; Donner, D.B.; Goebl, M.G.; Harrington, M.A.
Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB
Mol. Cell. Biol.
19
6500-6508
1999
Mus musculus, Mus musculus (Q9QZl0)
Manually annotated by BRENDA team
Honda, R.; Ohba, Y.; Yasuda, H.
14-3-3 Zeta protein binds to the carboxyl half of mouse wee1 kinase
Biochem. Biophys. Res. Commun.
230
262-265
1997
Mus musculus (P47810)
Manually annotated by BRENDA team
Honda, R.; Tanaka, H.; Ohba, Y.; Yasuda, H.
Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation
Chromosome Res.
3
300-308
1995
Mus musculus (P47810)
Manually annotated by BRENDA team
Anastasiadou, E.; Schwaller, J.
Role of constitutively activated protein tyrosine kinases in malignant myeloproliferative disorders: an update
Curr. Opin. Hematol.
10
40-48
2003
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Senis, Y.A.; Craig, A.W.; Greer, P.A.
Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis
Exp. Hematol.
31
673-681
2003
Mus musculus
Manually annotated by BRENDA team
Sangrar, W.; Gao, Y.; Bates, B.; Zirngibl, R.; Greer, P.A.
Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival
Exp. Hematol.
32
935-945
2004
Mus musculus
Manually annotated by BRENDA team
Law, S.; Maiti, D.; Palit, A.; Chaudhuri, S.
Role of biomodulators and involvement of protein tyrosine kinase on stem cell migration in normal and leukaemic mice
Immunol. Lett.
86
287-290
2003
Mus musculus
Manually annotated by BRENDA team
Gevrey, J.C.; Isaac, B.M.; Cox, D.
Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine)
J. Immunol.
175
3737-3745
2005
Mus musculus
Manually annotated by BRENDA team
Arnaud, L.; Ballif, B.A.; Cooper, J.A.
Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
Mol. Cell. Biol.
23
9293-9302
2003
Mus musculus, Mus musculus C57BL6J / 129Sv
Manually annotated by BRENDA team
Meyn, M.A., 3rd; Schreiner, S.J.; Dumitrescu, T.P.; Nau, G.J.; Smithgall, T.E.
Src family kinase activity is required for murine embryonic stem cell growth and differentiation
Mol. Pharmacol.
68
1320-1330
2005
Mus musculus
Manually annotated by BRENDA team
Okutani, D.; Lodyga, M.; Han, B.; Liu, M.
Src protein tyrosine kinase family and acute inflammatory responses
Am. J. Physiol. Lung Cell Mol. Physiol.
291
L129-L141
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Wallace, T.A.; Sayeski, P.P.
Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?
Cell Biochem. Biophys.
44
213-222
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Matsui, A.; Okigaki, M.; Amano, K.; Adachi, Y.; Jin, D.; Takai, S.; Yamashita, T.; Kawashima, S.; Kurihara, T.; Miyazaki, M.; Tateishi, K.; Matsunaga, S.; Katsume, A.; Honshou, S.; Takahashi, T.; Matoba, S.; Kusaba, T.; Tatsumi, T.; Matsubara, H.
Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function
Circulation
116
1041-1051
2007
Mus musculus
Manually annotated by BRENDA team
Angelucci, A.; Bologna, M.
Targeting vascular cell migration as a strategy for blocking angiogenesis: the central role of focal adhesion protein tyrosine kinase family
Curr. Pharm. Des.
13
2129-2145
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ortolano, S.; Hwang, I.Y.; Han, S.B.; Kehrl, J.H.
Roles for phosphoinositide 3-kinases, Brutons tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing
Eur. J. Immunol.
36
1285-1295
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Frenzel, K.; Wallace, T.A.; McDoom, I.; Xiao, H.D.; Capecchi, M.R.; Bernstein, K.E.; Sayeski, P.P.
A functional Jak2 tyrosine kinase domain is essential for mouse development
Exp. Cell Res.
312
2735-2744
2006
Mus musculus, Mus musculus (Q62120)
Manually annotated by BRENDA team
Zarbock, A.; Lowell, C.A.; Ley, K.
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1
Immunity
26
773-783
2007
Mus musculus
Manually annotated by BRENDA team
McGarrigle, D.; Shan, D.; Yang, S.; Huang, X.Y.
Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration
J. Biol. Chem.
281
10583-10588
2006
Mus musculus
Manually annotated by BRENDA team
Schmidt, N.W.; Thieu, V.T.; Mann, B.A.; Ahyi, A.N.; Kaplan, M.H.
Brutons tyrosine kinase is required for TLR-induced IL-10 production
J. Immunol.
177
7203-7210
2006
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Gururajan, M.; Dasu, T.; Shahidain, S.; Jennings, C.D.; Robertson, D.A.; Rangnekar, V.M.; Bondada, S.
Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth
J. Immunol.
178
111-121
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Pereira, D.B.; Chao, M.V.
The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts
J. Neurosci.
27
4859-4869
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Sirvent, A.; Boureux, A.; Simon, V.; Leroy, C.; Roche, S.
The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells
Oncogene
26
7313-7323
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Li, C.H.; Zhang, Q.; Teng, B.; Mustafa, S.J.; Huang, J.Y.; Yu, H.G.
Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531
Am. J. Physiol. Cell Physiol.
294
C355-C362
2008
Homo sapiens (P12931), Mus musculus
Manually annotated by BRENDA team
Yin, H.; Liu, J.; Li, Z.; Berndt, M.C.; Lowell, C.A.; Du, X.
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway
Blood
112
1139-1146
2008
Mus musculus (P25911)
Manually annotated by BRENDA team
Shinohara, M.; Koga, T.; Okamoto, K.; Sakaguchi, S.; Arai, K.; Yasuda, H.; Takai, T.; Kodama, T.; Morio, T.; Geha, R.S.; Kitamura, D.; Kurosaki, T.; Ellmeier, W.; Takayanagi, H.
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals
Cell
132
794-806
2008
Mus musculus (P24604), Mus musculus (P35991)
Manually annotated by BRENDA team
Tsuda, M.; Tozaki-Saitoh, H.; Masuda, T.; Toyomitsu, E.; Tezuka, T.; Yamamoto, T.; Inoue, K.
Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury
Glia
56
50-58
2008
Mus musculus (P25911), Rattus norvegicus (Q07014)
Manually annotated by BRENDA team
Lee, Y.G.; Chain, B.M.; Cho, J.Y.
Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaBalpha via activation of the phosphoinositide-3-kinase and Akt pathways
Int. J. Biochem. Cell Biol.
41
811-821
2009
Mus musculus (P48025)
Manually annotated by BRENDA team
Lee, K.G.; Xu, S.; Wong, E.T.; Tergaonkar, V.; Lam, K.P.
Brutons tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B Cells
J. Biol. Chem.
283
11189-11198
2008
Mus musculus
Manually annotated by BRENDA team
Lee, S.H.; Kim, T.; Jeong, D.; Kim, N.; Choi, Y.
The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation
J. Biol. Chem.
283
11526-11534
2008
Mus musculus
Manually annotated by BRENDA team
Williams, N.K.; Lucet, I.S.; Klinken, S.P.; Ingley, E.; Rossjohn, J.
Crystal structures of the Lyn protein tyrosine kinase domain in its apo- and inhibitor-bound state
J. Biol. Chem.
284
284-291
2009
Mus musculus
Manually annotated by BRENDA team
Jongstra-Bilen, J.; Puig Cano, A.; Hasija, M.; Xiao, H.; Smith, C.I.; Cybulsky, M.I.
Dual functions of Brutons tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis
J. Immunol.
181
288-298
2008
Mus musculus, Mus musculus (P24604)
Manually annotated by BRENDA team
Jelacic, T.M.; Thompson, D.; Hanson, C.; Cmarik, J.L.; Nishigaki, K.; Ruscetti, S.
The tyrosine kinase sf-Stk and its downstream signals are required for maintenance of friend spleen focus-forming virus-induced fibroblast transformation
J. Virol.
82
419-427
2008
Mus musculus
Manually annotated by BRENDA team
MacPartlin, M.; Smith, A.M.; Druker, B.J.; Honigberg, L.A.; Deininger, M.W.
Brutons tyrosine kinase is not essential for Bcr-Abl-mediated transformation of lymphoid or myeloid cells
Leukemia
22
1354-1360
2008
Mus musculus
Manually annotated by BRENDA team
Chaturvedi, G.; Arai, K.; Terranova, P.F.; Roby, K.F.
The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion
Mol. Cell. Biochem.
318
191-200
2008
Mus musculus
Manually annotated by BRENDA team
Parsa, K.V.; Butchar, J.P.; Rajaram, M.V.; Cremer, T.J.; Tridandapani, S.
The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk
Mol. Immunol.
45
3012-3021
2008
Homo sapiens (P43405), Mus musculus
Manually annotated by BRENDA team
Furuhata, A.; Kimura, A.; Shide, K.; Shimoda, K.; Murakami, M.; Ito, H.; Gao, S.; Yoshida, K.; Tagawa, Y.; Hagiwara, K.; Takagi, A.; Kojima, T.; Suzuki, M.; Abe, A.; Naoe, T.; Murate, T.
p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation
Biochem. Biophys. Res. Commun.
383
411-416
2009
Mus musculus (Q62120)
Manually annotated by BRENDA team
Pesu, M.; Laurence, A.; Kishore, N.; Zwillich, S.H.; Chan, G.; O‘Shea, J.J.
Therapeutic targeting of Janus kinases
Immunol. Rev.
223
132-142
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ghoreschi, K.; Laurence, A.; OShea, J.J.
Janus kinases in immune cell signaling
Immunol. Rev.
228
273-287
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Walz, C.; Cross, N.C.; Van Etten, R.A.; Reiter, A.
Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders
Leukemia
22
1320-1334
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kim, E.J.; Monje, F.J.; Li, L.; Hoeger, H.; Pollak, D.D.; Lubec, G.
Alzheimer's disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory
Cell. Mol. Life Sci.
70
743-759
2013
Mus musculus
Manually annotated by BRENDA team
Bao, Y.; Zheng, J.; Han, C.; Jin, J.; Han, H.; Liu, Y.; Lau, Y.; Tu, W.; Cao, X.
Tyrosine kinase Btk is required for NK cell activation
J. Biol. Chem.
287
23769-23778
2012
Homo sapiens (Q06187), Mus musculus, Mus musculus (P35991)
Manually annotated by BRENDA team
Lin, Y.L.; Roux, B.
Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases
J. Am. Chem. Soc.
135
14741-14753
2013
Gallus gallus (P00523), Homo sapiens (P06239), Mus musculus (P00520)
Manually annotated by BRENDA team
Nuendel, K.; Busto, P.; Debatis, M.; Marshak-Rothstein, A.
The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells
J. Leukoc. Biol.
94
865-875
2013
Mus musculus (P35991)
Manually annotated by BRENDA team
De Lucca, G.; Shi, Q.; Liu, Q.; Batt, D.; Beaudoin Bertrand, M.; Rampulla, R.; Mathur, A.; Discenza, L.; DArienzo, C.; Dai, J.; Obermeier, M.; Vickery, R.; Zhang, Y.; Yang, Z.; Marathe, P.; Tebben, A.; Muckelbauer, J.; Chang, C.; Zhang, H.; Gillooly, K.;
Small molecule reversible inhibitors of Bruton's tyrosine kinase (BTK): structure-activity relationships leading to the identification of 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)
J. Med. Chem.
59
7915-7935
2016
Mus musculus (P35991)
Manually annotated by BRENDA team
Francis, K.R.; Wei, L.; Yu, S.P.
Src tyrosine kinases regulate neuronal differentiation of mouse embryonic stem cells via modulation of voltage-gated sodium channel activity
Neurochem. Res.
40
674-687
2015
Mus musculus
Manually annotated by BRENDA team
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