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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Xenopus laevis and UniProt Accession Q91735

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IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Xenopus laevis
UNIPROT: Q91735
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Word Map
The taxonomic range for the selected organisms is: Xenopus laevis
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Adhesion-related kinase
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alpha platelet-derived growth factor receptor
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Anaplastic lymphoma kinase
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AXL oncogene
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Brain-specific kinase
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Breathless protein
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c-erbB3
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c-fgr
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c-fms
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c-kit
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c-Kit tyrosine kinase
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C-mer
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c-met
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C-ret
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C14
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Cadherin 96Ca
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CD115 antigen
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CD117 antigen
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CD135 antigen
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CD136 antigen
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CD140a antigen
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CD140b antigen
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CD167a antigen
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CD202b antigen
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CD220 antigen
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CD221 antigen
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CD246 antigen
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CDW136
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CEK4
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Cell adhesion kinase
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Derailed protein
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DFGF-R1
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Discoidin receptor tyrosine kinase
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Doughnut protein
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Dror
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Drosophila relative of ERBB
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DRT
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EBK
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EGF receptor tyrosine kinase
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Egfr
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EGFr TK
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Egg laying defective protein 15
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ELK
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Embryonic brain kinase
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Endothelial kinase receptor EK1
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EPH-and ELK-related kinase
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ephrin type-A receptor 4A
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ephrin type-A receptor 4B
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ephrin type-B receptor 1A
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Epidermal growth factor receptor-related protein
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Epithelial cell kinase
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erbB tyrosine kinase
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ErbB2 kinase
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ERK
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ETK
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fibroblast growth factor receptor 1
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fibroblast growth factor receptor 2
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fibroblast growth factor receptor 4
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Fms proto-oncogene
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GCTK
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GP145-TrkB
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GP145-TrkB/GP95-TrkB
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GP145-TrkC
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Gurken receptor
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Heartless protein
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HEK
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HEK3
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HEK4
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HEK6
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Heparin-binding growth factor receptor
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HGF receptor
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HGF-SF receptor
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hydroxyaryl-protein kinase
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HYK
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ILP receptor
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insulin receptor kinase
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insulin receptor protein-tyrosine kinase
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insulin receptor tyrosine kinase
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IR-related receptor
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IRK
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IRR
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Keratinocyte growth factor receptor
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Kinase insert domain receptor
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Kinase NYK
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Kinase VIK
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Linotte protein
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MEK4
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Met proto-oncogene tyrosine kinase
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Met-related kinase
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MFR
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MIR
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MLN 19
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mROR1
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mROR2
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MSP receptor
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NET
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NEU proto-oncogene
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Neurospecific receptor tyrosine kinase
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NRTK
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NUK
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P140 TEK
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p140-TrkA
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p180erbB4
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p185-Ron
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p185erbB2
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Pagliaccio
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PDGF-R-alpha
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PDGF-R-beta
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PDGFR kinase
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Protein-tyrosine kinase byk
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Protein-tyrosine kinase receptor MPK-11
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Proto-oncogene tyrosine-protein kinase Kit
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Receptor protein-tyrosine kinase HEK11
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Receptor protein-tyrosine kinase HEK5
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Receptor protein-tyrosine kinase HEK7
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Receptor protein-tyrosine kinase HEK8
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Receptor protein-tyrosine kinase TKT
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Receptor tyrosine kinase MerTK
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Receptor-activated Janus kinase
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RTK
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SCFR
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Sek-1 receptor tyrosine kinase
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Slow nerve growth factor receptor
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Stem cell-derived tyrosine kinase
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Torpedo protein
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TRK1 transforming tyrosine kinase protein
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TrkB tyrosine kinase
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TrkC tyrosine kinase
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Tunica interna endothelial cell kinase
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Tyrosine kinase CEK6 receptor
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Tyrosine kinase DDR
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Tyrosine kinase receptor HD-14
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Tyrosine kinase-type cell surface receptor HER2
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Tyrosine kinase-type cell surface receptor HER3
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Tyrosine kinase-type cell surface receptor HER4
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Tyrosine-protein kinase CAK
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Tyrosine-protein kinase CEK9
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Tyrosine-protein kinase DTK
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Tyrosine-protein kinase FLT3
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Tyrosine-protein kinase FRT
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Tyrosine-protein kinase receptor CEK10
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Tyrosine-protein kinase receptor CEK11
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Tyrosine-protein kinase receptor CEK5
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Tyrosine-protein kinase receptor CEK7
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Tyrosine-protein kinase receptor CEK8
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Tyrosine-protein kinase receptor CEPHA7
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Tyrosine-protein kinase receptor ECK
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Tyrosine-protein kinase receptor EEK
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Tyrosine-protein kinase receptor EPH
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Tyrosine-protein kinase receptor ESK
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Tyrosine-protein kinase receptor ETK1
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Tyrosine-protein kinase receptor FLT
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Tyrosine-protein kinase receptor FLT3
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Tyrosine-protein kinase receptor FLT4
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Tyrosine-protein kinase receptor HTK
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Tyrosine-protein kinase receptor PAG
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Tyrosine-protein kinase receptor QEK5
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Tyrosine-protein kinase receptor REK4
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Tyrosine-protein kinase receptor SEK
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Tyrosine-protein kinase receptor TCK
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Tyrosine-protein kinase receptor TEK
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Tyrosine-protein kinase receptor XEK
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Tyrosine-protein kinase receptor XELK
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Tyrosine-protein kinase receptor ZEK1
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Tyrosine-protein kinase receptor ZEK2
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Tyrosine-protein kinase receptor ZEK3
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Tyrosine-protein kinase RSE
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Tyrosine-protein kinase SKY
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Vascular permeability factor receptor
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Xenopus Elk-like kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
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?
additional information
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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inhibition of the insulin receptor tyrosine kinase and insulin action by dephosphorylation
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
metformin
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i.e. N,N-dimethylbiguanide or N,N-dimethylimidodicarbonimidic diamide, activates the insulin receptor tyrosine kinase by phosphorylation, and indirectly via inhibition of protein tyrosine phosphatase, metformin does not alter the order of substrate phosphorylation by the insulin receptor tyrosine kinase
additional information
-
activation of the insulin receptor by phosphorylation via its tyrosine kinase activity
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
mRNA expression in the brain, brachial arches, trigeminal facial ganglion, and the retina of the swimming tadpole stage of development
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
EPHB3_XENLA
974
1
108264
Swiss-Prot
Secretory Pathway (Reliability: 1)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
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autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, metformin activates the insulin receptor tyrosine kinase by phosphorylation at Tyr1150 and Tyr1151
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in COS cells
expression of XFGFR-2 cDNA in COS1 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Musci, T.J.; Amaya, E.; Kirschner, M.W.
Regulation of the fibroblast growth factor receptor in early Xenopus embryos
Proc. Natl. Acad. Sci. USA
87
8365-8369
1990
Xenopus laevis (P22182)
Manually annotated by BRENDA team
Jones, S.D.; Ho, L.; Smith, J.C.; Yordan, C.; Stiles, C.D.; Mercola, M.
The Xenopus platelet-derived growth factor alpha receptor: cDNA cloning and demonstration that mesoderm induction establishes the lineage-specific pattern of ligand and receptor gene expression
Dev. Genet.
14
185-193
1993
Xenopus laevis (P26619)
Manually annotated by BRENDA team
Friesel, R.; Brown, S.A.
Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development
Development
116
1051-1058
1992
Xenopus laevis (Q03364), Xenopus laevis
Manually annotated by BRENDA team
Jones, T.L.; Karavanova, I.; Maeno, M.; Ong, R.C.; Kung, H.F.; Daar, I.O.
Expression of an amphibian homolog of the Eph family of receptor tyrosine kinases is developmentally regulated
Oncogene
10
1111-1117
1995
Xenopus laevis (Q91571)
Manually annotated by BRENDA team
Winning, R.S.; Sargent, T.D.
Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos
Mech. Dev.
46
219-229
1994
Xenopus laevis (Q91694), Xenopus laevis
Manually annotated by BRENDA team
Scales, J.B.; Winning, R.S.; Renaud, C.S.; Shea, L.J.; Sargent, T.D.
Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development
Oncogene
11
1745-1752
1995
Xenopus laevis (Q91735)
Manually annotated by BRENDA team
Shiozaki, C.; Tashiro, K.; Asano-Miyoshi, M.; Saigo, K.; Emori, Y.; Shiokawa, K.
Cloning of cDNA and genomic DNA encoding fibroblast growth factor receptor-4 of Xenopus laevis
Gene
152
215-219
1995
Xenopus laevis (Q91742), Xenopus laevis
Manually annotated by BRENDA team
Xu, Q.; Alldus, G.; Holder, N.; Wilkinson, D.G.
Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain
Development
121
4005-4016
1995
Xenopus laevis (Q91845)
Manually annotated by BRENDA team
Holland, W.; Morrison, T.; Chang, Y.; Wiernsperger, N.; Stith, B.J.
Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase
Biochem. Pharmacol.
67
2081-2091
2004
Homo sapiens, Xenopus laevis
Manually annotated by BRENDA team