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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Drosophila melanogaster and UniProt Accession Q24488

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EC Tree
IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: Q24488
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tyrosine-protein kinase transmembrane receptor Ror
-
Adhesion-related kinase
-
-
-
-
Anaplastic lymphoma kinase
AXL oncogene
-
-
-
-
BDNF/NT-3 growth factors receptor
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
-
-
-
-
c-kit
-
-
-
-
c-Kit tyrosine kinase
-
-
-
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C-mer
-
-
-
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c-met
-
-
-
-
C-ret
-
-
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
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Discoidin receptor tyrosine kinase
-
-
-
-
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
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DRT
-
-
-
-
EBK
-
-
-
-
EGF receptor tyrosine kinase
-
-
-
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EGFr TK
-
-
-
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Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
Endothelial kinase receptor EK1
-
-
-
-
EPH-and ELK-related kinase
-
-
-
-
epidermal growth factor receptor
Epidermal growth factor receptor-related protein
-
-
-
-
Epithelial cell kinase
-
-
-
-
erbB tyrosine kinase
-
-
-
-
ErbB2 kinase
-
-
-
-
ETK
-
-
-
-
fibroblast growth factor receptor homolog 1
-
fibroblast growth factor receptor homolog 2
-
Fms proto-oncogene
-
-
-
-
GCTK
-
-
-
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GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
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HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
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hydroxyaryl-protein kinase
-
-
-
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HYK
-
-
-
-
ILP receptor
-
-
-
-
insulin receptor protein-tyrosine kinase
-
-
-
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IR-related receptor
-
-
-
-
IRK
-
-
-
-
IRR
-
-
-
-
Keratinocyte growth factor receptor
-
-
-
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Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
Linotte protein
-
-
-
-
MEK4
-
-
-
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met-related kinase
-
-
-
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
NET
-
-
-
-
NEU proto-oncogene
-
-
-
-
Neurospecific receptor tyrosine kinase
-
-
-
-
NRTK
-
-
-
-
NUK
-
-
-
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
Pagliaccio
-
-
-
-
PDGF-R-alpha
-
-
-
-
PDGF-R-beta
-
-
-
-
PDGFR kinase
-
-
-
-
Protein-tyrosine kinase byk
-
-
-
-
Protein-tyrosine kinase receptor MPK-11
-
-
-
-
Proto-oncogene tyrosine-protein kinase Kit
-
-
-
-
Receptor protein-tyrosine kinase HEK11
-
-
-
-
Receptor protein-tyrosine kinase HEK5
-
-
-
-
Receptor protein-tyrosine kinase HEK7
-
-
-
-
Receptor protein-tyrosine kinase HEK8
-
-
-
-
Receptor protein-tyrosine kinase TKT
-
-
-
-
receptor tyrosine kinase
-
Receptor tyrosine kinase MerTK
-
-
-
-
Receptor-activated Janus kinase
-
-
-
-
RET oncogene protein
-
SCFR
-
-
-
-
sevenless receptor tyrosine kinase
-
-
Slow nerve growth factor receptor
-
-
-
-
Stem cell-derived tyrosine kinase
-
-
-
-
Torpedo protein
-
-
-
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TRK1 transforming tyrosine kinase protein
-
-
-
-
TrkB tyrosine kinase
-
-
-
-
TrkC tyrosine kinase
-
-
-
-
Tunica interna endothelial cell kinase
-
-
-
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Tyrosine kinase CEK6 receptor
-
-
-
-
Tyrosine kinase DDR
-
-
-
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Tyrosine kinase receptor HD-14
-
-
-
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Tyrosine kinase-type cell surface receptor HER2
-
-
-
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Tyrosine kinase-type cell surface receptor HER3
-
-
-
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Tyrosine kinase-type cell surface receptor HER4
-
-
-
-
Tyrosine-protein kinase CAK
-
-
-
-
Tyrosine-protein kinase CEK9
-
-
-
-
tyrosine-protein kinase Dnt
-
tyrosine-protein kinase Drl
-
Tyrosine-protein kinase DTK
-
-
-
-
Tyrosine-protein kinase FLT3
-
-
-
-
Tyrosine-protein kinase FRT
-
-
-
-
Tyrosine-protein kinase receptor CEK10
-
-
-
-
Tyrosine-protein kinase receptor CEK11
-
-
-
-
Tyrosine-protein kinase receptor CEK5
-
-
-
-
Tyrosine-protein kinase receptor CEK7
-
-
-
-
Tyrosine-protein kinase receptor CEK8
-
-
-
-
Tyrosine-protein kinase receptor CEPHA7
-
-
-
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Tyrosine-protein kinase receptor ECK
-
-
-
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Tyrosine-protein kinase receptor EEK
-
-
-
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Tyrosine-protein kinase receptor EPH
-
-
-
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Tyrosine-protein kinase receptor ESK
-
-
-
-
Tyrosine-protein kinase receptor ETK1
-
-
-
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Tyrosine-protein kinase receptor FLT
-
-
-
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Tyrosine-protein kinase receptor FLT3
-
-
-
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Tyrosine-protein kinase receptor FLT4
-
-
-
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Tyrosine-protein kinase receptor HTK
-
-
-
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Tyrosine-protein kinase receptor PAG
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-
-
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Tyrosine-protein kinase receptor QEK5
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-
-
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Tyrosine-protein kinase receptor REK4
-
-
-
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Tyrosine-protein kinase receptor SEK
-
-
-
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Tyrosine-protein kinase receptor TCK
-
-
-
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Tyrosine-protein kinase receptor TEK
-
-
-
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tyrosine-protein kinase receptor torso
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Tyrosine-protein kinase receptor XEK
-
-
-
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Tyrosine-protein kinase receptor XELK
-
-
-
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Tyrosine-protein kinase receptor ZEK1
-
-
-
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Tyrosine-protein kinase receptor ZEK2
-
-
-
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Tyrosine-protein kinase receptor ZEK3
-
-
-
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Tyrosine-protein kinase RSE
-
-
-
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Tyrosine-protein kinase SKY
-
-
-
-
Vascular permeability factor receptor
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a [protein]-L-tyrosine
ADP + a [protein]-L-tyrosine phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Spry protein
-
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expressed specifically in the developing nervous system
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
Sevenless receptor tyrosine kinase binds directly to either the suppressor of cytokine signalling SOCS36E or the adaptor protein Drk, i.e. downstream of receptor kinase. In a mechanistic model, the competition between these two proteins for binding to the same docking site results in either attenuation of the Sevenless receptor tyrosine kinase transduction in cells that should not develop R7 photoreceptors or amplification of the Ras-MAPK signal only in the R7 precursor
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ROR1_DROME
685
1
78143
Swiss-Prot
Secretory Pathway (Reliability: 2)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
INR proreceptor of 280000 Da is processed proteolytically to generate an insulin-binding alpha subunit of 120000 Da and a beta subunit of 170000 Da with protein tyrosine kinase domain
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
a single amino acid substitution in the ATP-binding site of the putative kinase domain results in the synthesis of an inactive sev protein unable to determine cell fate
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
around 38% tyrosine phosphorylation events from Drosophila RTK proteins conserved on 185 human proteins are confirmed in vivo tyrosine phosphorylation events
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Rattus norvegicus (O08775), Homo sapiens (P00533), Homo sapiens (P04629), Homo sapiens (P06213), Homo sapiens (P07949), Homo sapiens (P17948), Homo sapiens (Q9UM73), Drosophila melanogaster (P04412), Caenorhabditis elegans (Q10656), Gallus gallus (Q91044), Gallus gallus (Q91987)
Manually annotated by BRENDA team
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (P13368), Drosophila melanogaster (Q07407), Drosophila melanogaster (Q24488), Drosophila melanogaster (Q27324), Drosophila melanogaster (Q9v422), Drosophila melanogaster (Q9v6k3), Drosophila melanogaster (Q9vie4)
Manually annotated by BRENDA team
Fernandez, R.; Tabarini, D.; Azpiazu, N.; Frasch, M.; Schlessinger, J.
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential
EMBO J.
14
3373-3384
1995
Drosophila melanogaster (P09208)
Manually annotated by BRENDA team
Nishida, Y.; Hata, M.; Nishizuka, Y.; Rutter, W.J.; Ebina, Y.
Cloning of a Drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor
Biochem. Biophys. Res. Commun.
141
474-481
1986
Drosophila melanogaster (P09208)
Manually annotated by BRENDA team
Petruzzelli, L.; Herrera, R.; Arenas-Garcia, R.; Fernandez, R.; Birnbaum, M.J.; Rosen, O.M.
Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody
Proc. Natl. Acad. Sci. USA
83
4710-4714
1986
Drosophila melanogaster (P09208)
Manually annotated by BRENDA team
Ruan, Y.; Chen, C.; Cao, Y.; Garofalo, R.S.
The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction
J. Biol. Chem.
270
4236-4243
1995
Drosophila melanogaster (P09208)
Manually annotated by BRENDA team
Basler, K.; Hafen, E.
Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain
Cell
54
299-311
1988
Drosophila melanogaster (P13368)
Manually annotated by BRENDA team
Bowtell, D.D.; Simon, M.A.; Rubin, G.M.
Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster
Genes Dev.
2
620-634
1988
Drosophila melanogaster (P13368), Drosophila melanogaster
Manually annotated by BRENDA team
Norton, P.A.; Hynes, R.O.; Rees, D.J.
Sevenless: seven found?
Cell
61
15-16
1990
Drosophila melanogaster (P13368)
Manually annotated by BRENDA team
Oates, A.C.; Wollberg, P.; Achen, M.G.; Wilks, A.F.
Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA
Biochem. Biophys. Res. Commun.
249
660-667
1998
Drosophila melanogaster (P13368), Drosophila melanogaster (Q24488), Drosophila melanogaster (Q9v6k3), Drosophila melanogaster
Manually annotated by BRENDA team
Sprenger, F.; Stevens, L.M.; Nusslein-Volhard, C.
The Drosophila gene torso encodes a putative receptor tyrosine kinase
Nature
338
478-483
1989
Drosophila melanogaster (P18475)
Manually annotated by BRENDA team
Sprenger, F.; Trosclair, M.M.; Morrison, D.K.
Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction
Mol. Cell. Biol.
13
1163-1172
1993
Drosophila melanogaster (P18475)
Manually annotated by BRENDA team
Ito, M.; Matsui, T.; Taniguchi, T.; Chihara, K.
Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog
Gene
139
215-218
1994
Drosophila melanogaster (Q07407), Drosophila melanogaster
Manually annotated by BRENDA team
Shishido, E.; Higashijima, S.; Emori, Y.; Saigo, K.
Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos
Development
117
751-761
1993
Drosophila melanogaster (Q07407), Drosophila melanogaster (Q09147)
Manually annotated by BRENDA team
Glazer, L.; Shilo, B.Z.
The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension
Genes Dev.
5
697-705
1991
Drosophila melanogaster (Q09147)
Manually annotated by BRENDA team
Klambt, C.; Glazer, L.; Shilo, B.Z.
breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells
Genes Dev.
6
1668-1678
1992
Drosophila melanogaster (Q09147)
Manually annotated by BRENDA team
Shishido, E.; Emori, Y.; Saigo, K.
Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction
FEBS Lett.
289
235-238
1991
Drosophila melanogaster (Q07407), Drosophila melanogaster (Q09147), Drosophila melanogaster
Manually annotated by BRENDA team
Wilson, C.; Goberdhan, D.C.; Steller, H.
Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases
Proc. Natl. Acad. Sci. USA
90
7109-7113
1993
Drosophila melanogaster (Q24488)
Manually annotated by BRENDA team
Callahan, C.A.; Bonkovsky, J.L.; Scully, A.L.; Thomas, J.B.
Derailed is required for muscle attachment site selection in Drosophila
Development
122
2761-2767
1996
Drosophila melanogaster (Q27324)
Manually annotated by BRENDA team
Callahan, C.A.; Muralidhar, M.G.; Lundgren, S.E.; Scully, A.L.; Thomas, J.B.
Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
Nature
376
171-174
1995
Drosophila melanogaster (Q27324)
Manually annotated by BRENDA team
Dura, J.M.; Taillebourg, E.; Preat, T.
The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product
FEBS Lett.
370
250-254
1995
Drosophila melanogaster (Q27324)
Manually annotated by BRENDA team
Taillebourg, E.; Dura, J.M.
A novel mechanism for P element homing in Drosophila
Proc. Natl. Acad. Sci. USA
96
6856-6861
1999
Drosophila melanogaster (Q27324)
Manually annotated by BRENDA team
Oates, A.C.; Bonkovsky, J.L.; Irvine, D.V.; Kelly, L.E.; Thomas, J.B.; Wilks, A.F.
Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila
Mech. Dev.
78
165-169
1998
Drosophila melanogaster (Q9v422)
Manually annotated by BRENDA team
Savant-Bhonsale, S.; Friese, M.; McCoon, P.; Montell, D.J.
A Drosophila derailed homolog, doughnut, expressed in invaginating cells during embryogenesis
Gene
231
155-161
1999
Drosophila melanogaster (Q9v422)
Manually annotated by BRENDA team
Oishi, I.; Sugiyama, S.; Liu, Z.J.; Yamamura, H.; Nishida, Y.; Minami, Y.
A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling
J. Biol. Chem.
272
11916-11923
1997
Drosophila melanogaster (Q9v6k3)
Manually annotated by BRENDA team
Sugaya, R.; Ishimaru, S.; Hosoya, T.; Saigo, K.; Emori, Y.
A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells
Mech. Dev.
45
139-145
1994
Drosophila melanogaster (Q9vie4)
Manually annotated by BRENDA team
Bazigou, E.; Apitz, H.; Johansson, J.; Loren, C.E.; Hirst, E.M.; Chen, P.L.; Palmer, R.H.; Salecker, I.
Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila
Cell
128
961-975
2007
Drosophila melanogaster
Manually annotated by BRENDA team
Hubbard, S.R.; Miller, W.T.
Receptor tyrosine kinases: mechanisms of activation and signaling
Curr. Opin. Cell Biol.
19
117-123
2007
Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team
Mason, J.M.; Morrison, D.J.; Basson, M.A.; Licht, J.D.
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
Trends Cell Biol.
16
45-54
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Krishnamoorthy, S.
Receptor tyrosine kinase (RTK) mediated tyrosine phosphor-proteome from Drosophila S2 (ErbB1) cells reveals novel signaling networks
PLoS ONE
3
e2877
2008
Drosophila melanogaster (P09208), Homo sapiens (P35916), Homo sapiens
Manually annotated by BRENDA team
Almudi, I.; Corominas, M.; Serras, F.
Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity
J. Cell Sci.
123
3857-3862
2010
Drosophila melanogaster
Manually annotated by BRENDA team