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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Caenorhabditis elegans and UniProt Accession Q10656
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2.7.10.1 receptor protein-tyrosine kinaseIUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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- 2.7.10.1
- angiogenesis
- leukemia
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nsclc
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non-small
- myeloid
- adenocarcinoma
- tumour
- women
- subtypes
- estrogen
- vessel
-
progression-free
- mapk
- gastrointestinal
- metastases
- marrow
- node
- erk
-
angiogenic
- colorectal
- 3-kinase
-
first-line
-
resect
- mesenchymal
-
mitogen
-
hematopoietic
- phosphatidylinositol
-
clinicopathological
- gastric
- ovarian
- tumorigenesis
- progesterone
-
autocrine
-
neurotrophic
- neoplasm
-
signal-regulated
-
immunotherapy
- integrins
- sarcoma
- glioblastoma
-
radiotherapy
-
oncology
-
relapse
-
monotherapy
- analysis
- pharmacology
- synthesis
- diagnostics
- drug development
- medicine
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Adhesion-related kinase
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Anaplastic lymphoma kinase
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AXL oncogene
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Brain-specific kinase
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Breathless protein
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c-erbB3
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c-fgr
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c-fms
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c-kit
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c-Kit tyrosine kinase
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C-mer
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c-met
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C-ret
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C14
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Cadherin 96Ca
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CD115 antigen
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CD117 antigen
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CD135 antigen
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CD136 antigen
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CD140a antigen
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CD140b antigen
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CD167a antigen
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CD202b antigen
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CD220 antigen
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CD221 antigen
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CD246 antigen
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CDW136
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CEK4
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Cell adhesion kinase
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Derailed protein
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DFGF-R1
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Discoidin receptor tyrosine kinase
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Doughnut protein
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Dror
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Drosophila relative of ERBB
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DRT
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EBK
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EGF receptor tyrosine kinase
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Egfr
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EGFr TK
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Egg laying defective protein 15
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ELK
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Embryonic brain kinase
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Endothelial kinase receptor EK1
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EPH-and ELK-related kinase
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Epidermal growth factor receptor-related protein
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Epithelial cell kinase
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erbB tyrosine kinase
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ErbB2 kinase
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ERK
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ETK
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Fms proto-oncogene
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GCTK
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GP145-TrkB
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GP145-TrkB/GP95-TrkB
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GP145-TrkC
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Gurken receptor
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Heartless protein
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HEK
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HEK3
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HEK4
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HEK6
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Heparin-binding growth factor receptor
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HGF receptor
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HGF-SF receptor
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hydroxyaryl-protein kinase
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HYK
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ILP receptor
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insulin receptor protein-tyrosine kinase
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IR-related receptor
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IRK
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IRR
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Keratinocyte growth factor receptor
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Kinase insert domain receptor
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Kinase NYK
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Kinase VIK
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Let-23 receptor protein-tyrosine kinase
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Linotte protein
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MEK4
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Met proto-oncogene tyrosine kinase
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Met-related kinase
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MFR
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MIR
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MLN 19
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mROR1
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mROR2
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MSP receptor
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NET
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NEU proto-oncogene
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Neurospecific receptor tyrosine kinase
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NRTK
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NUK
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P140 TEK
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p140-TrkA
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p180erbB4
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p185-Ron
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p185erbB2
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Pagliaccio
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PDGF-R-alpha
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PDGF-R-beta
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PDGFR kinase
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Protein-tyrosine kinase byk
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Protein-tyrosine kinase receptor MPK-11
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Proto-oncogene tyrosine-protein kinase Kit
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Receptor protein-tyrosine kinase HEK11
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Receptor protein-tyrosine kinase HEK5
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Receptor protein-tyrosine kinase HEK7
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Receptor protein-tyrosine kinase HEK8
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Receptor protein-tyrosine kinase TKT
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Receptor tyrosine kinase MerTK
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Receptor-activated Janus kinase
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RTK
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SCFR
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Slow nerve growth factor receptor
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Stem cell-derived tyrosine kinase
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Torpedo protein
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TRK1 transforming tyrosine kinase protein
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TrkB tyrosine kinase
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TrkC tyrosine kinase
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Tunica interna endothelial cell kinase
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Tyrosine kinase CEK6 receptor
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Tyrosine kinase DDR
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Tyrosine kinase receptor HD-14
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Tyrosine kinase-type cell surface receptor HER2
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Tyrosine kinase-type cell surface receptor HER3
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Tyrosine kinase-type cell surface receptor HER4
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Tyrosine-protein kinase CAK
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Tyrosine-protein kinase CEK9
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Tyrosine-protein kinase DTK
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Tyrosine-protein kinase FLT3
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Tyrosine-protein kinase FRT
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Tyrosine-protein kinase receptor CEK10
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Tyrosine-protein kinase receptor CEK11
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Tyrosine-protein kinase receptor CEK5
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Tyrosine-protein kinase receptor CEK7
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Tyrosine-protein kinase receptor CEK8
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Tyrosine-protein kinase receptor CEPHA7
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Tyrosine-protein kinase receptor ECK
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Tyrosine-protein kinase receptor EEK
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Tyrosine-protein kinase receptor EPH
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Tyrosine-protein kinase receptor ESK
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Tyrosine-protein kinase receptor ETK1
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Tyrosine-protein kinase receptor FLT
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Tyrosine-protein kinase receptor FLT3
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Tyrosine-protein kinase receptor FLT4
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Tyrosine-protein kinase receptor HTK
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Tyrosine-protein kinase receptor PAG
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Tyrosine-protein kinase receptor QEK5
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Tyrosine-protein kinase receptor REK4
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Tyrosine-protein kinase receptor SEK
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Tyrosine-protein kinase receptor TCK
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Tyrosine-protein kinase receptor TEK
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Tyrosine-protein kinase receptor XEK
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Tyrosine-protein kinase receptor XELK
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Tyrosine-protein kinase receptor ZEK1
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Tyrosine-protein kinase receptor ZEK2
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Tyrosine-protein kinase receptor ZEK3
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Tyrosine-protein kinase RSE
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Tyrosine-protein kinase SKY
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Vascular permeability factor receptor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
functions in neural and epithelial morphogenesis
-
-
?
additional information
?
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-
functions in neural and epithelial morphogenesis
-
-
?
additional information
?
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
-
?
additional information
?
-
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
-
?
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
?
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
?
additional information
?
-
receptor for the inductive signal required for vulval development
-
-
?
additional information
?
-
-
receptor for the inductive signal required for vulval development
-
-
?
additional information
?
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
-
?
additional information
?
-
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
-
?
additional information
?
-
-
receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development
-
-
?
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
?
additional information
?
-
may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development
-
-
?
additional information
?
-
receptor for the inductive signal required for vulval development
-
-
?
additional information
?
-
-
receptor for the inductive signal required for vulval development
-
-
?
additional information
?
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
-
?
additional information
?
-
-
acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation
-
-
?
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
basolateral membrane domain of the epithelial vulval precursor cells
expressed during postembryonic development in the large hypodermal syncytium
basolateral membrane domain of the epithelial vulval precursor cells
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). EGL15_CAEEL
1040
2
118956
Swiss-Prot
Secretory Pathway (Reliability: 3)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
mutations in the Caenorhabditis elegans let-23 EGFR-like gene
additional information
-
mutations in the Caenorhabditis elegans let-23 EGFR-like gene
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
may serve as a new target for the development of new antibiotics
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Rattus norvegicus (O08775), Homo sapiens (P00533), Homo sapiens (P04629), Homo sapiens (P06213), Homo sapiens (P07949), Homo sapiens (P17948), Homo sapiens (Q9UM73), Drosophila melanogaster (P04412), Caenorhabditis elegans (Q10656), Gallus gallus (Q91044), Gallus gallus (Q91987)
George, S.E.; Simokat, K.; Hardin, J.; Chisholm, A.D.
The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans
Cell
92
633-643
1998
Caenorhabditis elegans (O61460), Caenorhabditis elegans
Aroian, R.V.; Koga, M.; Mendel, J.E.; Ohshima, Y.; Sternberg, P.W.
The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
Nature
348
693-699
1990
Caenorhabditis elegans (P24348), Caenorhabditis elegans
Aroian, R.V.; Lesa, G.M.; Sternberg, P.W.
Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function
EMBO J.
13
360-366
1994
Caenorhabditis elegans (P24348), Caenorhabditis elegans
Sakai, T.; Koga, M.; Ohshima, Y.
Genomic structure and 5' regulatory regions of the let-23 gene in the nematode C. elegans
J. Mol. Biol.
256
548-555
1996
Caenorhabditis elegans (P24348), Caenorhabditis elegans
Whitfield, C.W.; Benard, C.; Barnes, T.; Hekimi, S.; Kim, S.K.
Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10
Mol. Biol. Cell
10
2087-2100
1999
Caenorhabditis elegans (P24348), Caenorhabditis elegans
EXTERNAL LINKS (specific for EC-Number 2.7.10.1)
Transporter Classification Database (TCDB): 8.A.23.1.30, 8.A.23.1.29, 8.A.23.1.9, 8.A.23.1.38, 8.A.23.1.13, 8.A.23.1.39, 8.A.23.1.17, 1.A.87.2.6, 8.A.23.1.37, 8.A.23.1.7, 8.A.23.1.15, 8.A.23.1.16
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