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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Escherichia coli and UniProt Accession P76387

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IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Escherichia coli
UNIPROT: P76387
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Word Map
The taxonomic range for the selected organisms is: Escherichia coli
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tyrosine-protein kinase Wzc
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Adhesion-related kinase
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Anaplastic lymphoma kinase
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AXL oncogene
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-
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Brain-specific kinase
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Breathless protein
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-
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c-erbB3
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-
-
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c-fgr
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-
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c-fms
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-
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c-kit
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c-Kit tyrosine kinase
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C-mer
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c-met
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-
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C-ret
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-
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C14
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-
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Cadherin 96Ca
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-
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CD115 antigen
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-
-
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CD117 antigen
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-
-
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CD135 antigen
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CD136 antigen
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-
-
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CD140a antigen
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-
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CD140b antigen
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-
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CD167a antigen
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CD202b antigen
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CD220 antigen
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-
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CD221 antigen
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-
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CD246 antigen
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-
-
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CDW136
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-
-
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CEK4
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-
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Cell adhesion kinase
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-
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Derailed protein
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-
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DFGF-R1
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-
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Discoidin receptor tyrosine kinase
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Doughnut protein
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-
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Dror
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-
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Drosophila relative of ERBB
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-
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DRT
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-
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EBK
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EGF receptor tyrosine kinase
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Egfr
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EGFr TK
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-
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Egg laying defective protein 15
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-
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ELK
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Embryonic brain kinase
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Endothelial kinase receptor EK1
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EPH-and ELK-related kinase
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Epidermal growth factor receptor-related protein
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-
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Epithelial cell kinase
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-
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erbB tyrosine kinase
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ErbB2 kinase
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ERK
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ETK
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Fms proto-oncogene
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GCTK
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-
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GP145-TrkB
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-
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GP145-TrkB/GP95-TrkB
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-
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GP145-TrkC
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Gurken receptor
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Heartless protein
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-
-
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HEK
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HEK3
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-
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HEK4
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-
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HEK6
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-
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Heparin-binding growth factor receptor
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-
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HGF receptor
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-
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HGF-SF receptor
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-
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hydroxyaryl-protein kinase
-
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HYK
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-
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ILP receptor
-
-
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insulin receptor protein-tyrosine kinase
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-
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IR-related receptor
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-
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IRK
-
-
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IRR
-
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Keratinocyte growth factor receptor
-
-
-
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Kinase insert domain receptor
-
-
-
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Kinase NYK
-
-
-
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Kinase VIK
-
-
-
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Linotte protein
-
-
-
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MEK4
-
-
-
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Met proto-oncogene tyrosine kinase
-
-
-
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Met-related kinase
-
-
-
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MFR
-
-
-
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MIR
-
-
-
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MLN 19
-
-
-
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mROR1
-
-
-
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mROR2
-
-
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MSP receptor
-
-
-
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NET
-
-
-
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NEU proto-oncogene
-
-
-
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Neurospecific receptor tyrosine kinase
-
-
-
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NRTK
-
-
-
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NUK
-
-
-
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P140 TEK
-
-
-
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p140-TrkA
-
-
-
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p180erbB4
-
-
-
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p185-Ron
-
-
-
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p185erbB2
-
-
-
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Pagliaccio
-
-
-
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PDGF-R-alpha
-
-
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PDGF-R-beta
-
-
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PDGFR kinase
-
-
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Protein-tyrosine kinase byk
-
-
-
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Protein-tyrosine kinase receptor MPK-11
-
-
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Proto-oncogene tyrosine-protein kinase Kit
-
-
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Receptor protein-tyrosine kinase HEK11
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-
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Receptor protein-tyrosine kinase HEK5
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-
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Receptor protein-tyrosine kinase HEK7
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-
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Receptor protein-tyrosine kinase HEK8
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-
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Receptor protein-tyrosine kinase TKT
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-
-
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Receptor tyrosine kinase MerTK
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-
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Receptor-activated Janus kinase
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RTK
-
-
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SCFR
-
-
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Slow nerve growth factor receptor
-
-
-
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Stem cell-derived tyrosine kinase
-
-
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Torpedo protein
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-
-
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TRK1 transforming tyrosine kinase protein
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-
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TrkB tyrosine kinase
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-
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TrkC tyrosine kinase
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-
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Tunica interna endothelial cell kinase
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-
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Tyrosine kinase CEK6 receptor
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-
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Tyrosine kinase DDR
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Tyrosine kinase receptor HD-14
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Tyrosine kinase-type cell surface receptor HER2
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Tyrosine kinase-type cell surface receptor HER3
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Tyrosine kinase-type cell surface receptor HER4
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-
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Tyrosine-protein kinase CAK
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-
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Tyrosine-protein kinase CEK9
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-
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Tyrosine-protein kinase DTK
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-
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tyrosine-protein kinase Etk
Tyrosine-protein kinase FLT3
-
-
-
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Tyrosine-protein kinase FRT
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-
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Tyrosine-protein kinase receptor CEK10
-
-
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Tyrosine-protein kinase receptor CEK11
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-
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Tyrosine-protein kinase receptor CEK5
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Tyrosine-protein kinase receptor CEK7
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Tyrosine-protein kinase receptor CEK8
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Tyrosine-protein kinase receptor CEPHA7
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-
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Tyrosine-protein kinase receptor ECK
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Tyrosine-protein kinase receptor EEK
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Tyrosine-protein kinase receptor EPH
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Tyrosine-protein kinase receptor ESK
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Tyrosine-protein kinase receptor ETK1
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Tyrosine-protein kinase receptor FLT
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Tyrosine-protein kinase receptor FLT3
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Tyrosine-protein kinase receptor FLT4
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Tyrosine-protein kinase receptor HTK
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Tyrosine-protein kinase receptor PAG
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Tyrosine-protein kinase receptor QEK5
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Tyrosine-protein kinase receptor REK4
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Tyrosine-protein kinase receptor SEK
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Tyrosine-protein kinase receptor TCK
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Tyrosine-protein kinase receptor TEK
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Tyrosine-protein kinase receptor XEK
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Tyrosine-protein kinase receptor XELK
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Tyrosine-protein kinase receptor ZEK1
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Tyrosine-protein kinase receptor ZEK2
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Tyrosine-protein kinase receptor ZEK3
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Tyrosine-protein kinase RSE
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Tyrosine-protein kinase SKY
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tyrosine-protein kinase Wzc
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Vascular permeability factor receptor
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
ATP + poly(Glu:Tyr)
ADP + phosphorylated poly(Glu:Tyr)
show the reaction diagram
-
-
-
?
ATP + tyrosine-protein kinase Etp
ADP + phosphotyrosine-protein kinase Etp
show the reaction diagram
-
-
-
?
ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
show the reaction diagram
autophosphorylation
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
inner membrane protein
Manually annotated by BRENDA team
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
may serve as a new target for the development of new antibiotics
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dassa, J.; Marck, C.; Boquet, P.L.
The complete nucleotide sequence of the Escherichia coli gene appA reveals significant homology between pH 2.5 acid phosphatase and glucose-1-phosphatase
J. Bacteriol.
172
5497-5500
1990
Escherichia coli (P38134)
Manually annotated by BRENDA team
Grangeasse, C.; Doublet, P.; Cozzone, A.J.
Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process
J. Biol. Chem.
277
7127-7135
2002
Escherichia coli (P76387)
Manually annotated by BRENDA team
Perna, N.T.; Plunkett, G.; Burland, V.; Mau, B.; Glasner, J.D.; et al.
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
Nature
409
529-533
2001
Escherichia coli (Q8X7L9), Escherichia coli (Q8XC28)
Manually annotated by BRENDA team
Hayashi, T.; Makino, K.; Ohnishi, M.; Kurokawa, K.; Ishii, K.; et al.
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12
DNA Res.
8
11-22
2001
Escherichia coli (Q8X7L9), Escherichia coli (Q8XC28), Escherichia coli O157 (Q8X7L9)
Manually annotated by BRENDA team
Vincent, C.; Duclos, B.; Grangeasse, C.; Vaganay, E.; Riberty, M.; Cozzone, A.J.; Doublet, P.
Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in gram-negative bacteria
J. Mol. Biol.
304
311-321
2000
Escherichia coli (P38134), Escherichia coli (P76387)
Manually annotated by BRENDA team
Vincent, C.; Doublet, P.; Grangeasse, C.; Vaganay, E.; Cozzone, A.J.; Duclos, B.
Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb
J. Bacteriol.
181
3472-3477
1999
Escherichia coli (P76387)
Manually annotated by BRENDA team
Ilan, O.; Bloch, Y.; Frankel, G.; Ullrich, H.; Geider, K.; Rosenshine, I.
Protein tyrosine kinases in bacterial pathogens are associated with virulence and production of exopolysaccharide
EMBO J.
18
3241-3248
1999
Escherichia coli (P58764), Escherichia coli
Manually annotated by BRENDA team
Blattner, F.R.; Plunkett, G.; Bloch, C.A.; Perna, N.T.; et al.
The complete genome sequence of Escherichia coli K-12
Science
277
1453-1474
1997
Escherichia coli (P38134), Escherichia coli (P76387)
Manually annotated by BRENDA team
Stevenson, G.; Andrianopoulos, K.; Hobbs, M.; Reeves, P.R.
Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid
J. Bacteriol.
178
4885-4893
1996
Escherichia coli (P76387)
Manually annotated by BRENDA team
Oshima, T.; Aiba, H.; Baba, T.; Fujita, K.; Hayashi, K.; Honjo, A.; et al.
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map
DNA Res.
3
137-155
1996
Escherichia coli (P38134)
Manually annotated by BRENDA team
Itoh, T.; Aiba, H.; Baba, T.; Hayashi, K.; Inada, T.; Isono, K.; et al.
A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map
DNA Res.
3
379-392
1996
Escherichia coli (P76387)
Manually annotated by BRENDA team
Borodovsky, M.; Rudd, K.E.; Koonin, E.V.
Intrinsic and extrinsic approaches for detecting genes in a bacterial genome
Nucleic Acids Res.
22
4756-4767
1994
Escherichia coli (P38134)
Manually annotated by BRENDA team