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Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2,
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tyrosine-protein kinase Wzc
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Adhesion-related kinase
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Anaplastic lymphoma kinase
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Brain-specific kinase
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Breathless protein
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c-Kit tyrosine kinase
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Cell adhesion kinase
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Discoidin receptor tyrosine kinase
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Drosophila relative of ERBB
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EGF receptor tyrosine kinase
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Egg laying defective protein 15
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Embryonic brain kinase
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Endothelial kinase receptor EK1
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EPH-and ELK-related kinase
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Epidermal growth factor receptor-related protein
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Epithelial cell kinase
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erbB tyrosine kinase
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Fms proto-oncogene
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GP145-TrkB/GP95-TrkB
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Heartless protein
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Heparin-binding growth factor receptor
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hydroxyaryl-protein kinase
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insulin receptor protein-tyrosine kinase
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IR-related receptor
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Keratinocyte growth factor receptor
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Kinase insert domain receptor
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Met proto-oncogene tyrosine kinase
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Met-related kinase
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NEU proto-oncogene
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Neurospecific receptor tyrosine kinase
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Protein-tyrosine kinase byk
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Protein-tyrosine kinase receptor MPK-11
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Proto-oncogene tyrosine-protein kinase Kit
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Receptor protein-tyrosine kinase HEK11
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Receptor protein-tyrosine kinase HEK5
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Receptor protein-tyrosine kinase HEK7
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Receptor protein-tyrosine kinase HEK8
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Receptor protein-tyrosine kinase TKT
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Receptor tyrosine kinase MerTK
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Receptor-activated Janus kinase
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Slow nerve growth factor receptor
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Stem cell-derived tyrosine kinase
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TRK1 transforming tyrosine kinase protein
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TrkB tyrosine kinase
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TrkC tyrosine kinase
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Tunica interna endothelial cell kinase
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Tyrosine kinase CEK6 receptor
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Tyrosine kinase DDR
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Tyrosine kinase receptor HD-14
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Tyrosine kinase-type cell surface receptor HER2
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Tyrosine kinase-type cell surface receptor HER3
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Tyrosine kinase-type cell surface receptor HER4
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Tyrosine-protein kinase CAK
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Tyrosine-protein kinase CEK9
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Tyrosine-protein kinase DTK
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tyrosine-protein kinase Etk
Tyrosine-protein kinase FLT3
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Tyrosine-protein kinase FRT
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Tyrosine-protein kinase receptor CEK10
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Tyrosine-protein kinase receptor CEK11
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Tyrosine-protein kinase receptor CEK5
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Tyrosine-protein kinase receptor CEK7
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Tyrosine-protein kinase receptor CEK8
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Tyrosine-protein kinase receptor CEPHA7
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Tyrosine-protein kinase receptor ECK
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Tyrosine-protein kinase receptor EEK
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Tyrosine-protein kinase receptor EPH
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Tyrosine-protein kinase receptor ESK
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Tyrosine-protein kinase receptor ETK1
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Tyrosine-protein kinase receptor FLT
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Tyrosine-protein kinase receptor FLT3
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Tyrosine-protein kinase receptor FLT4
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Tyrosine-protein kinase receptor HTK
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Tyrosine-protein kinase receptor PAG
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Tyrosine-protein kinase receptor QEK5
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Tyrosine-protein kinase receptor REK4
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Tyrosine-protein kinase receptor SEK
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Tyrosine-protein kinase receptor TCK
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Tyrosine-protein kinase receptor TEK
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Tyrosine-protein kinase receptor XEK
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Tyrosine-protein kinase receptor XELK
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Tyrosine-protein kinase receptor ZEK1
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Tyrosine-protein kinase receptor ZEK2
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Tyrosine-protein kinase receptor ZEK3
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Tyrosine-protein kinase RSE
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Tyrosine-protein kinase SKY
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tyrosine-protein kinase Wzc
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Vascular permeability factor receptor
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tyrosine-protein kinase Etk
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tyrosine-protein kinase Etk
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tyrosine-protein kinase Etk
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ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
ATP + poly(Glu:Tyr)
ADP + phosphorylated poly(Glu:Tyr)
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ATP + tyrosine-protein kinase Etp
ADP + phosphotyrosine-protein kinase Etp
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ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation
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additional information
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ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
autophosphorylation
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ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
The C-terminal domain alone can undergo autophosphorylation and thus appears to harbor the protein-tyrosine kinase activity. By contrast, the N-terminal domain is not phosphorylated when incubated either alone or in the presence of the C-domain, and does not influence the extent of phosphorylation of the C-domain. The C-domain contains six different sites of phosphorylation. Among these, five are located at the C-terminal end of the molecule in the form of a tyrosine cluster Tyr708, Tyr710, Tyr711, Tyr713, and Tyr715, and one site is located upstream, at Tyr569. The Tyr569 residue can autophosphorylate through an intramolecular process, whereas the tyrosine cluster cannot. The phosphorylation of Tyr569 results in an increased protein kinase activity of Wzc, which can, in turn, phosphorylate the five terminal tyrosines through an intermolecular process. It is concluded that protein Wzc autophosphorylates by using a cooperative two-step mechanism that involves both intraphosphorylation and interphosphorylation
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ATP + tyrosine-protein kinase Wcz
ADP + phosphotyrosine-protein kinase Wcz
efficient autophosphorylation in presence of ATP
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additional information
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enzyme is involved in signal transduction
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additional information
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phosphotyrosine-protein phosphatase Wzb is able to dephosphorylate previously autophosphorylated Wzc. Reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria
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additional information
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phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
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additional information
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phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
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additional information
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enzyme is involved in the production of the extracellular polysaccharide colanic acid
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additional information
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involved in exopolysaccharide production and virulence
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additional information
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involved in exopolysaccharide production and virulence
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additional information
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additional information
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enzyme is involved in signal transduction
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additional information
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phosphotyrosine-protein phosphatase Wzb is able to dephosphorylate previously autophosphorylated Wzc. Reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria
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?
additional information
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phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
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additional information
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phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced
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additional information
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enzyme is involved in the production of the extracellular polysaccharide colanic acid
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additional information
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involved in exopolysaccharide production and virulence
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additional information
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involved in exopolysaccharide production and virulence
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Dassa, J.; Marck, C.; Boquet, P.L.
The complete nucleotide sequence of the Escherichia coli gene appA reveals significant homology between pH 2.5 acid phosphatase and glucose-1-phosphatase
J. Bacteriol.
172
5497-5500
1990
Escherichia coli (P38134)
brenda
Grangeasse, C.; Doublet, P.; Cozzone, A.J.
Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process
J. Biol. Chem.
277
7127-7135
2002
Escherichia coli (P76387)
brenda
Perna, N.T.; Plunkett, G.; Burland, V.; Mau, B.; Glasner, J.D.; et al.
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
Nature
409
529-533
2001
Escherichia coli (Q8X7L9), Escherichia coli (Q8XC28)
brenda
Hayashi, T.; Makino, K.; Ohnishi, M.; Kurokawa, K.; Ishii, K.; et al.
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12
DNA Res.
8
11-22
2001
Escherichia coli (Q8X7L9), Escherichia coli (Q8XC28), Escherichia coli O157 (Q8X7L9)
brenda
Vincent, C.; Duclos, B.; Grangeasse, C.; Vaganay, E.; Riberty, M.; Cozzone, A.J.; Doublet, P.
Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in gram-negative bacteria
J. Mol. Biol.
304
311-321
2000
Escherichia coli (P38134), Escherichia coli (P76387)
brenda
Vincent, C.; Doublet, P.; Grangeasse, C.; Vaganay, E.; Cozzone, A.J.; Duclos, B.
Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb
J. Bacteriol.
181
3472-3477
1999
Escherichia coli (P76387)
brenda
Ilan, O.; Bloch, Y.; Frankel, G.; Ullrich, H.; Geider, K.; Rosenshine, I.
Protein tyrosine kinases in bacterial pathogens are associated with virulence and production of exopolysaccharide
EMBO J.
18
3241-3248
1999
Escherichia coli (P58764), Escherichia coli
brenda
Blattner, F.R.; Plunkett, G.; Bloch, C.A.; Perna, N.T.; et al.
The complete genome sequence of Escherichia coli K-12
Science
277
1453-1474
1997
Escherichia coli (P38134), Escherichia coli (P76387)
brenda
Stevenson, G.; Andrianopoulos, K.; Hobbs, M.; Reeves, P.R.
Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid
J. Bacteriol.
178
4885-4893
1996
Escherichia coli (P76387)
brenda
Oshima, T.; Aiba, H.; Baba, T.; Fujita, K.; Hayashi, K.; Honjo, A.; et al.
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map
DNA Res.
3
137-155
1996
Escherichia coli (P38134)
brenda
Itoh, T.; Aiba, H.; Baba, T.; Hayashi, K.; Inada, T.; Isono, K.; et al.
A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map
DNA Res.
3
379-392
1996
Escherichia coli (P76387)
brenda
Borodovsky, M.; Rudd, K.E.; Koonin, E.V.
Intrinsic and extrinsic approaches for detecting genes in a bacterial genome
Nucleic Acids Res.
22
4756-4767
1994
Escherichia coli (P38134)
brenda