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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Gallus gallus and UniProt Accession P54755
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2.7.10.1 receptor protein-tyrosine kinaseIUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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- 2.7.10.1
- angiogenesis
- leukemia
-
nsclc
-
non-small
- myeloid
- adenocarcinoma
- tumour
- women
- subtypes
- estrogen
- vessel
-
progression-free
- mapk
- gastrointestinal
- metastases
- marrow
- node
- erk
-
angiogenic
- colorectal
- 3-kinase
-
first-line
-
resect
- mesenchymal
-
mitogen
-
hematopoietic
- phosphatidylinositol
-
clinicopathological
- gastric
- ovarian
- tumorigenesis
- progesterone
-
autocrine
-
neurotrophic
- neoplasm
-
signal-regulated
-
immunotherapy
- integrins
- sarcoma
- glioblastoma
-
radiotherapy
-
oncology
-
relapse
-
monotherapy
- analysis
- pharmacology
- synthesis
- diagnostics
- drug development
- medicine
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Adhesion-related kinase
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Anaplastic lymphoma kinase
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AXL oncogene
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Brain-specific kinase
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Breathless protein
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-
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c-erbB3
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c-fgr
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c-fms
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c-kit
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c-Kit tyrosine kinase
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C-mer
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c-met
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C-ret
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C14
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Cadherin 96Ca
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CD115 antigen
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CD117 antigen
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CD135 antigen
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CD136 antigen
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CD140a antigen
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CD140b antigen
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CD167a antigen
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CD202b antigen
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CD220 antigen
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CD221 antigen
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CD246 antigen
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CDW136
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CEK4
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Cell adhesion kinase
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Derailed protein
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DFGF-R1
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Discoidin receptor tyrosine kinase
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Doughnut protein
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Dror
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Drosophila relative of ERBB
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DRT
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EBK
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EGF receptor tyrosine kinase
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Egfr
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EGFr TK
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Egg laying defective protein 15
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ELK
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Embryonic brain kinase
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Endothelial kinase receptor EK1
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EPH-and ELK-related kinase
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Epidermal growth factor receptor-related protein
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Epithelial cell kinase
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erbB tyrosine kinase
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ErbB2 kinase
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ERK
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ETK
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Fms proto-oncogene
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GCTK
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GP145-TrkB
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GP145-TrkB/GP95-TrkB
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GP145-TrkC
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Gurken receptor
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Heartless protein
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HEK
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HEK3
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HEK4
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HEK6
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Heparin-binding growth factor receptor
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HGF receptor
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HGF-SF receptor
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hydroxyaryl-protein kinase
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HYK
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ILP receptor
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insulin receptor protein-tyrosine kinase
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IR-related receptor
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IRK
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IRR
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Keratinocyte growth factor receptor
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Kinase insert domain receptor
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Kinase NYK
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Kinase VIK
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Linotte protein
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MEK4
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Met proto-oncogene tyrosine kinase
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Met-related kinase
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MFR
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MIR
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MLN 19
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mROR1
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mROR2
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MSP receptor
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NET
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NEU proto-oncogene
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Neurospecific receptor tyrosine kinase
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NRTK
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NUK
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P140 TEK
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p140-TrkA
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p180erbB4
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p185-Ron
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p185erbB2
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Pagliaccio
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PDGF-R-alpha
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PDGF-R-beta
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PDGFR kinase
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Protein-tyrosine kinase byk
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Protein-tyrosine kinase receptor MPK-11
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Proto-oncogene tyrosine-protein kinase Kit
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Receptor protein-tyrosine kinase HEK11
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Receptor protein-tyrosine kinase HEK5
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Receptor protein-tyrosine kinase HEK7
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Receptor protein-tyrosine kinase HEK8
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Receptor protein-tyrosine kinase TKT
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Receptor tyrosine kinase MerTK
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Receptor-activated Janus kinase
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RTK
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SCFR
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Slow nerve growth factor receptor
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Stem cell-derived tyrosine kinase
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Torpedo protein
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TRK1 transforming tyrosine kinase protein
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TrkB tyrosine kinase
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TrkC tyrosine kinase
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Tunica interna endothelial cell kinase
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Tyrosine kinase CEK6 receptor
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Tyrosine kinase DDR
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Tyrosine kinase receptor HD-14
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Tyrosine kinase-type cell surface receptor HER2
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Tyrosine kinase-type cell surface receptor HER3
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Tyrosine kinase-type cell surface receptor HER4
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Tyrosine-protein kinase CAK
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Tyrosine-protein kinase CEK9
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Tyrosine-protein kinase DTK
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Tyrosine-protein kinase FLT3
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Tyrosine-protein kinase FRT
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Tyrosine-protein kinase receptor CEK10
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Tyrosine-protein kinase receptor CEK11
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Tyrosine-protein kinase receptor CEK5
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Tyrosine-protein kinase receptor CEK7
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Tyrosine-protein kinase receptor CEK8
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Tyrosine-protein kinase receptor CEPHA7
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Tyrosine-protein kinase receptor ECK
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Tyrosine-protein kinase receptor EEK
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Tyrosine-protein kinase receptor EPH
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Tyrosine-protein kinase receptor ESK
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Tyrosine-protein kinase receptor ETK1
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Tyrosine-protein kinase receptor FLT
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Tyrosine-protein kinase receptor FLT3
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Tyrosine-protein kinase receptor FLT4
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Tyrosine-protein kinase receptor HTK
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Tyrosine-protein kinase receptor PAG
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Tyrosine-protein kinase receptor QEK5
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Tyrosine-protein kinase receptor REK4
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Tyrosine-protein kinase receptor SEK
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Tyrosine-protein kinase receptor TCK
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Tyrosine-protein kinase receptor TEK
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Tyrosine-protein kinase receptor XEK
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Tyrosine-protein kinase receptor XELK
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Tyrosine-protein kinase receptor ZEK1
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Tyrosine-protein kinase receptor ZEK2
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Tyrosine-protein kinase receptor ZEK3
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Tyrosine-protein kinase RSE
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Tyrosine-protein kinase SKY
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Vascular permeability factor receptor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + protein tyrosine phosphate
autophosphorylation
-
-
?
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
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may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
-
may play an important role during development and in signal transduction pathways
-
-
?
additional information
?
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
-
Cek9 plays an active role in embryonic signal transduction pathways
-
-
?
additional information
?
-
Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
in the skeletal muscle of the thigh a sharp decrease in Cek5 expression is detected at the time of terminal muscle differentiation
expression of chick EphA7 during segmentation of the central and peripheral nervous system EphA7 expression is restricted to prosomeres 1 and 2 in the diencephalon and all the rhombomeres in the hindbrain during segmentation stages. Later on, a superimposed pattern appears that correlates with the formation of several axonal tracts. In the somitic mesoderm, the expression correlates with segmentation and the guidance of both neural crest and motor axons through the sclerotomes
-
4fold increase in expression in vagal versus sacral neural crest cells
expression of Cek5 in the brain gradually diminishes during embryonic development
Cek5 variant is expressed in the brain, but not in other tissues of the 10-day chick embryo
expression of Cek5 in the brain gradually diminishes during embryonic development
Cek5 variant is expressed in the brain, but not in other tissues of the 10-day chick embryo
at embryonic day 2, Cek9 immunoreactivity is concentrated in the eye, the brain, the posterior region of the neural tube, and the most recently formed somites. Later in development, Cek9 expression is widespread but particularly prominent in neural tissues
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). EPHA5_CHICK
1013
0
112246
Swiss-Prot
Secretory Pathway (Reliability: 2)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
RET is a cell-intrinsic marker that regulates hindgut colonization by sacral neural crest cells, and has the ability to promote the enteric nervous system developmental potential of sacral neural crest cells towards that of vagal neural crest cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Rattus norvegicus (O08775), Homo sapiens (P00533), Homo sapiens (P04629), Homo sapiens (P06213), Homo sapiens (P07949), Homo sapiens (P17948), Homo sapiens (Q9UM73), Drosophila melanogaster (P04412), Caenorhabditis elegans (Q10656), Gallus gallus (Q91044), Gallus gallus (Q91987)
Araujo, M.; Nieto, M.A.
The expression of chick EphA7 during segmentation of the central and peripheral nervous system
Mech. Dev.
68
173-177
1997
Gallus gallus (O42422)
Pasquale, E.B.
A distinctive family of embryonic protein-tyrosine kinase receptors
Proc. Natl. Acad. Sci. USA
87
5812-5816
1990
Gallus gallus (P18460), Gallus gallus (P18461), Gallus gallus
Lee, P.L.; Johnson, D.E.; Cousens, L.S.; Fried, V.A.; Williams, L.T.
Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor
Science
245
57-60
1989
Gallus gallus (P21804)
Pasquale, E.B.; Singer, S.J.
Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library
Proc. Natl. Acad. Sci. USA
86
5449-5453
1989
Gallus gallus (P21804), Gallus gallus
Pasquale, E.B.
Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family
Cell Regul.
2
523-534
1991
Gallus gallus (P28693), Gallus gallus
Sajjadi, F.G.; Pasquale, E.B.
Five novel avian Eph-related tyrosine kinases are differentially expressed
Oncogene
8
1807-1813
1993
Gallus gallus (P28693), Gallus gallus (P54755), Gallus gallus (Q07496), Gallus gallus (Q07497)
Sajjadi, F.G.; Pasquale, E.B.; Subramani, S.
Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor
New Biol.
3
769-778
1991
Gallus gallus (P29318), Gallus gallus, Mus musculus (P29319), Mus musculus
Siever, D.A.; Verderame, M.F.
Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts
Gene
148
219-226
1994
Gallus gallus (P54755), Gallus gallus
Ohta, K.; Nakamura, M.; Hirokawa, K.; Tanaka, S.; Iwama, A.; Suda, T.; Ando, M.; Tanaka, H.
The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development
Mech. Dev.
54
59-69
1996
Gallus gallus (Q07496)
Soans, C.; Holash, J.A.; Pavlova, Y.; Pasquale, E.B.
Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9
J. Cell Biol.
135
781-795
1996
Gallus gallus (Q07497), Gallus gallus
Sasaki, E.; Okamura, H.; Chikamune, T.; Kanai, Y.; Watanabe, M.; Naito, M.; Sakurai, M.
Cloning and expression of the chicken c-kit proto-oncogene
Gene
128
257-261
1993
Gallus gallus (Q08156), Gallus gallus
Wagh, P.K.; Peace, B.E.; Waltz, S.E.
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis
Adv. Cancer Res.
100
1-33
2008
Bos taurus, Canis lupus, Gallus gallus, Equus caballus, Homo sapiens, Macaca mulatta, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Takifugu rubripes
EXTERNAL LINKS (specific for EC-Number 2.7.10.1)
Transporter Classification Database (TCDB): 8.A.23.1.30, 8.A.23.1.29, 8.A.23.1.9, 8.A.23.1.38, 8.A.23.1.13, 8.A.23.1.39, 8.A.23.1.17, 1.A.87.2.6, 8.A.23.1.37, 8.A.23.1.7, 8.A.23.1.15, 8.A.23.1.16
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