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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Homo sapiens and UniProt Accession P29322

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IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Homo sapiens
UNIPROT: P29322
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A-type platelet-derived growth factor receptor
265516
-
Adhesion-related kinase
-
-
-
-
ALK
247
-
ALK tyrosine kinase receptor
265731
-
alpha platelet-derived growth factor receptor
265516
-
Anaplastic lymphoma kinase
angiopoietin 1 receptor
265630
-
AXL kinase
265557
-
AXL oncogene
-
-
-
-
basic fibroblast growth factor receptor 1
265496
-
basic-FGF receptor
265496
-
BDNF/NT-3 growth factors receptor
265665
-
beta platelet-derived growth factor receptor
265489
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
Brt
247
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
c-kit
c-Kit receptor protein-tyrosine kinase
265493
-
c-Kit receptor tyrosine kinase
247
-
c-Kit RTK
247
-
c-Kit tyrosine kinase
-
-
-
-
c-kitR tyrosine kinase
265493
-
C-mer
c-met
c-Met receptor tyrosine kinase
c-Met RTK
247
-
C-ret
-
-
-
-
C-SRC
247
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117
247
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
cKit
247
-
CLD1
247
-
CLD2
247
-
colony-stimulating factor-1 receptor
247
-
CSF-1 receptor
247
also known as c-fms and CD115
CSF-1R
247
-
DDR1
265656
-
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
discoidin domain receptor 1
265656
-
discoidin domain receptor 2
265666
-
discoidin domain receptor tyrosine kinase 1
265656
-
Discoidin receptor tyrosine kinase
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
DTK
247
-
DTK receptor tyrosine kinase
265646
-
EBK
-
-
-
-
EGF receptor
EGF receptor protein-tyrosine kinase
247
-
EGF receptor tyrosine kinase
EGF RTK
265568
-
EGF TK
247
-
EGF-R
247
-
EGFR kinase
247
-
EGFR protein tyrosine kinase
247
-
EGFr TK
-
-
-
-
EGFR tyrosine kinase
EGFR-TK
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
embryonic receptor kinase
265571
-
EmRK2
265571
-
Endothelial kinase receptor EK1
-
-
-
-
Eph receptor tyrosine kinase
265615
-
EPH-and ELK-related kinase
-
-
-
-
EphA1
EphA1 receptor
247
-
EPHA1 receptor tyrosine kinase
265527
-
EphA2
EPHA4
265615
-
EphB3
265606
-
ephrin type-A receptor 1
265527
-
ephrin type-A receptor 2
265549
-
ephrin type-A receptor 3
265552
-
ephrin type-A receptor 4
265615
-
ephrin type-A receptor 5
265609
-
ephrin type-A receptor 7
265663
-
ephrin type-A receptor 8
265553
-
ephrin type-B receptor 1
265614
-
ephrin type-B receptor 2
265554
-
ephrin type-B receptor 3
265606
-
ephrin type-B receptor 4
265612
-
ephrine receptor
247
-
epidermal growth factor receptor
epidermal growth factor receptor 2
247
-
epidermal growth factor receptor 4
265662
-
epidermal growth factor receptor kinase
247
-
epidermal growth factor receptor tyrosine kinase
epidermal growth factor receptor tyrosine kinase inhibitor
247
-
Epidermal growth factor receptor-related protein
-
-
-
-
epidermal growth factor type II receptor
247
-
epidermal growth factor-receptor
247
-
epidermal growth-factor receptor tyrosine kinase
247
-
Epithelial cell kinase
epithelial discoidin domain receptor 1
265656
-
erb-B1
265729
-
ErbB receptor protein-tyrosine kinase
247
-
erbB tyrosine kinase
-
-
-
-
ErbB-1
265729
-
ErbB-2
265467
-
ErbB-4 receptor
265662
-
ErbB-4 tyrosine kinase
247
-
ERBB1
ErbB1 tyrosine kinase
247
-
ErbB2 kinase
-
-
-
-
erbB2 receptor tyrosine kinase
ErbB2 tyrosine kinase
247
-
ErbB4
247
-
ErbB4 receptor
247
-
ERK
-
-
-
-
erlotinib
247
-
erythropoietin-producing hepatocellular receptor tyrosine kinase subtype A2
247
-
erythropoietin-producing human hepatocellular carcinoma B3
265606
-
ETK
-
-
-
-
FGF receptor
265496
-
FGF receptor tyrosine kinase
247
-
FGFR-4
265533
-
FGFR1K
265496
-
FGFR2
FGFR3
FGFR4
247
-
fibroblast growth factor receptor
247
-
fibroblast growth factor receptor 1
265496
-
fibroblast growth factor receptor 3
265534
-
fibroblast growth factor receptor 4
265533
-
fibroblast growth factor receptor BFR-2
265528
-
FL cytokine receptor
265573
-
Flk-1
247
-
Flt-1
247
-
FLT-3
247
-
FLT3 kinase
265573
-
FLT3 receptor protein
247
-
FLT4
265568
-
FLT4 receptor tyrosine kinase
265568
-
Fms proto-oncogene
-
-
-
-
fms-like tyrosine kinase 3
247
-
GCTK
-
-
-
-
GHR
247
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
growth hormone receptor
247
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK 2
265606
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
hepatocyte growth factor receptor
HER receptor protein-tyrosine kinase
247
-
HER-1
265729
-
Her-2
265467
-
Her1 tyrosine kinase
247
-
HER2neu
247
-
HER3
265531
-
HER3/ERRB3
265531
-
HER4
247
-
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
high affinity nerve growth factor receptor
265714
-
HTK
265612
-
human epidermal growth factor receptor2
247
-
hydroxyaryl-protein kinase
-
-
-
-
HYK
-
-
-
-
IGF-1 receptor
247
-
IGF-1R
IGF-IR
247
-
IGFR tyrosine kinase
247
-
ILP receptor
-
-
-
-
insulin receptor
insulin receptor kinase
247
-
insulin receptor protein tyrosine kinase
247
-
insulin receptor protein-tyrosine kinase
-
-
-
-
insulin receptor tyrosine kinase
247
-
insulin receptor-beta subunit
247
-
insulin receptor-related protein
265508
-
insulin-growth factor-1 receptor
247
-
insulin-like growth factor 1 receptor
265479
-
insulin-like growth factor I receptor
265479
-
insulin-like growth factor receptor
247
-
insulin-like growth factor type I receptor
247
-
Insulin-like growth factor-1 receptor
247
-
Insulin-like Growth Factor-1 receptor tyrosine kinase
247
-
IR kinase
247
-
iR-beta subunit
247
-
IR-PTK
247
-
IR-related receptor
-
-
-
-
KDR/fetal liver kinase-1
247
-
KDR/Flk-1
247
-
Keratinocyte growth factor receptor
KGF receptor
247
-
KGFR
247
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
KIT kinase
265493
-
Kit protein-tyrosine kinase
247
-
KIT receptor tyrosine kinase
247
-
leukocyte tyrosine kinase receptor
265555
-
Linotte protein
-
-
-
-
M-CSF receptor
247
-
macrophage colony stimulating factor I receptor
265476
-
macrophage colony-stimulating factor receptor
247
-
macrophage stimulating 1 receptor
247
-
macrophage stimulating 1-receptor
247
-
macrophage-colony stimulating factor receptor
247
-
macrophage-stimulating protein receptor
265642
-
mast/stem cell growth factor receptor
265493
-
MEK4
-
-
-
-
MER kinase
265660
-
MET kinase
265481
-
Met proto-oncogene tyrosine kinase
-
-
-
-
Met receptor-tyrosine kinase
247
-
Met RTK
247
-
Met-related kinase
-
-
-
-
Met/hepatocyte growth factor receptor tyrosine kinase
265481
-
MFR
-
-
-
-
MIR
-
-
-
-
MLN 19
-
-
-
-
mROR1
-
-
-
-
mROR2
-
-
-
-
MSP receptor
-
-
-
-
MST1R
247
-
muscle-specific receptor tyrosine kinase
247
-
muscle-specific receptor-tyrosine kinase
247
-
nerve growth factor receptor
247
-
NEU proto-oncogene
-
-
-
-
neuregulin receptor ErbB-4
265662
-
Neurospecific receptor tyrosine kinase
-
-
-
-
neurotrophin tyrosine receptor kinase
247
-
non-receptor protein tyrosine kinase
247
-
NRTK
-
-
-
-
NT-3 growth factor receptor
265664
-
NUK
-
-
-
-
orphan receptor tyrosine kinase
247
-
P140 TEK
-
-
-
-
p140-TrkA
-
-
-
-
p145c-kit
265493
-
p180erbB4
-
-
-
-
p185-Ron
-
-
-
-
p185erbB2
-
-
-
-
p190MET kinase
265481
-
p75 neurotrophin receptor
247
-
p75NTR
247
-
Pagliaccio
-
-
-
-