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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Homo sapiens and UniProt Accession P00533

for references in articles please use BRENDA:EC2.7.10.1

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IUBMB Comments

The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.

The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms

Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
EGFR tyrosine kinase
-
epidermal growth factor receptor
-
epidermal growth factor receptor tyrosine kinase
-
A-type platelet-derived growth factor receptor
-
Adhesion-related kinase
-
-
-
-
ALK tyrosine kinase receptor
-
alpha platelet-derived growth factor receptor
-
Anaplastic lymphoma kinase
angiopoietin 1 receptor
-
AXL kinase
-
AXL oncogene
-
-
-
-
basic fibroblast growth factor receptor 1
-
basic-FGF receptor
-
BDNF/NT-3 growth factors receptor
-
beta platelet-derived growth factor receptor
-
Brain-specific kinase
-
-
-
-
Breathless protein
-
-
-
-
c-erbB3
-
-
-
-
c-fgr
-
-
-
-
c-fms
c-kit
c-Kit receptor protein-tyrosine kinase
-
c-Kit receptor tyrosine kinase
-
-
c-Kit RTK
-
-
c-Kit tyrosine kinase
-
-
-
-
c-kitR tyrosine kinase
-
C-mer
c-met
c-Met receptor tyrosine kinase
c-Met RTK
-
-
C-ret
-
-
-
-
C-SRC
-
-
C14
-
-
-
-
Cadherin 96Ca
-
-
-
-
CD115 antigen
-
-
-
-
CD117
-
-
CD117 antigen
-
-
-
-
CD135 antigen
-
-
-
-
CD136 antigen
-
-
-
-
CD140a antigen
-
-
-
-
CD140b antigen
-
-
-
-
CD167a antigen
-
-
-
-
CD202b antigen
-
-
-
-
CD220 antigen
-
-
-
-
CD221 antigen
-
-
-
-
CD246 antigen
-
-
-
-
CDW136
-
-
-
-
CEK4
-
-
-
-
Cell adhesion kinase
-
-
-
-
cKit
-
-
CLD1
-
-
CLD2
-
-
colony-stimulating factor-1 receptor
-
-
CSF-1 receptor
-
also known as c-fms and CD115
Derailed protein
-
-
-
-
DFGF-R1
-
-
-
-
discoidin domain receptor 1
-
discoidin domain receptor 2
-
discoidin domain receptor tyrosine kinase 1
-
Discoidin receptor tyrosine kinase
Doughnut protein
-
-
-
-
Dror
-
-
-
-
Drosophila relative of ERBB
-
-
-
-
DRT
-
-
-
-
DTK receptor tyrosine kinase
-
EBK
-
-
-
-
EGF receptor
EGF receptor protein-tyrosine kinase
-
-
EGF receptor tyrosine kinase
EGF TK
-
-
EGF-R
-
-
EGFR kinase
-
-
EGFR protein tyrosine kinase
-
-
EGFr TK
-
-
-
-
EGFR tyrosine kinase
-
-
EGFR-TK
-
-
Egg laying defective protein 15
-
-
-
-
ELK
-
-
-
-
Embryonic brain kinase
-
-
-
-
embryonic receptor kinase
-
Endothelial kinase receptor EK1
-
-
-
-
Eph receptor tyrosine kinase
-
EPH-and ELK-related kinase
-
-
-
-
EphA1
EphA1 receptor
-
-
EPHA1 receptor tyrosine kinase
-
EphA2
ephrin type-A receptor 1
-
ephrin type-A receptor 2
-
ephrin type-A receptor 3
-
ephrin type-A receptor 4
-
ephrin type-A receptor 5
-
ephrin type-A receptor 7
-
ephrin type-A receptor 8
-
ephrin type-B receptor 1
-
ephrin type-B receptor 2
-
ephrin type-B receptor 3
-
ephrin type-B receptor 4
-
ephrine receptor
-
-
epidermal growth factor receptor 2
-
-
epidermal growth factor receptor 4
-
epidermal growth factor receptor kinase
-
-
epidermal growth factor receptor tyrosine kinase
-
-
epidermal growth factor receptor tyrosine kinase inhibitor
-
-
Epidermal growth factor receptor-related protein
-
-
-
-
epidermal growth factor type II receptor
-
-
epidermal growth factor-receptor
-
-
epidermal growth-factor receptor tyrosine kinase
-
-
Epithelial cell kinase
epithelial discoidin domain receptor 1
-
ErbB receptor protein-tyrosine kinase
-
-
erbB tyrosine kinase
-
-
-
-
ErbB-4 receptor
-
ErbB-4 tyrosine kinase
-
-
ERBB1
ErbB1 tyrosine kinase
-
-
ErbB2 kinase
-
-
-
-
erbB2 receptor tyrosine kinase
ErbB2 tyrosine kinase
-
-
ErbB4 receptor
-
-
ERK
-
-
-
-
erlotinib
-
-
erythropoietin-producing hepatocellular receptor tyrosine kinase subtype A2
-
-
erythropoietin-producing human hepatocellular carcinoma B3
-
ETK
-
-
-
-
FGF receptor
-
FGF receptor tyrosine kinase
-
-
FGFR2
FGFR3
FGFR4
-
-
fibroblast growth factor receptor
-
-
fibroblast growth factor receptor 1
-
fibroblast growth factor receptor 4
-
fibroblast growth factor receptor BFR-2
-
Flk-1
-
-
Flt-1
-
-
FLT3 kinase
-
FLT3 receptor protein
-
-
FLT4 receptor tyrosine kinase
-
Fms proto-oncogene
-
-
-
-
fms-like tyrosine kinase 3
-
-
GCTK
-
-
-
-
GP145-TrkB
-
-
-
-
GP145-TrkB/GP95-TrkB
-
-
-
-
GP145-TrkC
-
-
-
-
growth hormone receptor
-
-
Gurken receptor
-
-
-
-
Heartless protein
-
-
-
-
HEK3
-
-
-
-
HEK4
-
-
-
-
HEK6
-
-
-
-
Heparin-binding growth factor receptor
-
-
-
-
hepatocyte growth factor receptor
HER receptor protein-tyrosine kinase
-
-
Her1 tyrosine kinase
-
-
HER2neu
-
-
HER3/ERRB3
-
HER4
-
-
HGF receptor
-
-
-
-
HGF-SF receptor
-
-
-
-
high affinity nerve growth factor receptor
-
human epidermal growth factor receptor2
-
-
hydroxyaryl-protein kinase
-
-
-
-
HYK
-
-
-
-
IGF-1 receptor
-
-
IGF-1R
IGF-IR
-
-
IGFR tyrosine kinase
-
-
ILP receptor
-
-
-
-
insulin receptor
insulin receptor kinase
-
-
insulin receptor protein tyrosine kinase
-
-
insulin receptor protein-tyrosine kinase
-
-
-
-
insulin receptor tyrosine kinase
-
-
insulin receptor-beta subunit
-
-
insulin receptor-related protein
-
insulin-growth factor-1 receptor
-
-
insulin-like growth factor 1 receptor
-
insulin-like growth factor I receptor
-
insulin-like growth factor receptor
-
-
insulin-like growth factor type I receptor
-
-
Insulin-like growth factor-1 receptor
-
-
Insulin-like Growth Factor-1 receptor tyrosine kinase
-
-
IR kinase
-
-
iR-beta subunit
-
-
IR-PTK
-
-
IR-related receptor
-
-
-
-
KDR/fetal liver kinase-1
-
-
KDR/Flk-1
-
-
Keratinocyte growth factor receptor
KGF receptor
-
-
KGFR
-
-
Kinase insert domain receptor
-
-
-
-
Kinase NYK
-
-
-
-
Kinase VIK
-
-
-
-
KIT kinase
-
Kit protein-tyrosine kinase
-
-