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Information on EC 2.7.10.1 - receptor protein-tyrosine kinase and Organism(s) Canis lupus familiaris and UniProt Accession O97799

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IUBMB Comments
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans . In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
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This record set is specific for:
Canis lupus familiaris
UNIPROT: O97799
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The taxonomic range for the selected organisms is: Canis lupus familiaris
The enzyme appears in selected viruses and cellular organisms
Synonyms
tyrosine kinase, epidermal growth factor receptor, insulin receptor, c-kit, erlotinib, c-met, erbb2, egf receptor, receptor tyrosine kinase, her-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mast/stem cell growth factor receptor
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receptor tyrosine kinase
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Adhesion-related kinase
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Anaplastic lymphoma kinase
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AXL oncogene
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Brain-specific kinase
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-
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Breathless protein
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-
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c-erbB3
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-
-
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c-fgr
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-
-
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c-fms
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-
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c-kit
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c-Kit tyrosine kinase
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C-mer
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c-met
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C-ret
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-
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C14
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-
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Cadherin 96Ca
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-
-
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CD115 antigen
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-
-
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CD117 antigen
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-
-
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CD135 antigen
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-
-
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CD136 antigen
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-
-
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CD140a antigen
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-
-
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CD140b antigen
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-
-
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CD167a antigen
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-
-
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CD202b antigen
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-
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CD220 antigen
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-
-
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CD221 antigen
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-
-
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CD246 antigen
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-
-
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CDW136
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-
-
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CEK4
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-
-
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Cell adhesion kinase
-
-
-
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Derailed protein
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-
-
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DFGF-R1
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-
-
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Discoidin receptor tyrosine kinase
-
-
-
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Doughnut protein
-
-
-
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Dror
-
-
-
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Drosophila relative of ERBB
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-
-
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DRT
-
-
-
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EBK
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-
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EGF receptor tyrosine kinase
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-
-
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Egfr
-
-
-
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EGFr TK
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-
-
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Egg laying defective protein 15
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-
-
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ELK
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-
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Embryonic brain kinase
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-
-
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Endothelial kinase receptor EK1
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-
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EPH-and ELK-related kinase
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-
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Epidermal growth factor receptor-related protein
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Epithelial cell kinase
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-
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erbB tyrosine kinase
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-
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ErbB2 kinase
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ERK
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-
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ETK
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Fms proto-oncogene
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-
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GCTK
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-
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GP145-TrkB
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-
-
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GP145-TrkB/GP95-TrkB
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-
-
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GP145-TrkC
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-
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Gurken receptor
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-
-
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Heartless protein
-
-
-
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HEK
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-
-
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HEK3
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-
-
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HEK4
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-
-
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HEK6
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-
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Heparin-binding growth factor receptor
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-
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HGF receptor
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-
-
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HGF-SF receptor
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-
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hydroxyaryl-protein kinase
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-
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HYK
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-
-
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ILP receptor
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-
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insulin receptor protein-tyrosine kinase
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IR-related receptor
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-
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IRK
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IRR
-
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Keratinocyte growth factor receptor
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Kinase insert domain receptor
-
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Kinase NYK
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Kinase VIK
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Linotte protein
-
-
-
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MEK4
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-
-
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Met proto-oncogene tyrosine kinase
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-
-
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Met-related kinase
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-
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MFR
-
-
-
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MIR
-
-
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MLN 19
-
-
-
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mROR1
-
-
-
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mROR2
-
-
-
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MSP receptor
-
-
-
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NET
-
-
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NEU proto-oncogene
-
-
-
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Neurospecific receptor tyrosine kinase
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-
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NRTK
-
-
-
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NUK
-
-
-
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P140 TEK
-
-
-
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p140-TrkA
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-
-
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p180erbB4
-
-
-
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p185-Ron
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-
-
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p185erbB2
-
-
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Pagliaccio
-
-
-
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PDGF-R-alpha
-
-
-
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PDGF-R-beta
-
-
-
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PDGFR kinase
-
-
-
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Protein-tyrosine kinase byk
-
-
-
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Protein-tyrosine kinase receptor MPK-11
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-
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Proto-oncogene tyrosine-protein kinase Kit
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-
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Receptor protein-tyrosine kinase HEK11
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-
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Receptor protein-tyrosine kinase HEK5
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-
-
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Receptor protein-tyrosine kinase HEK7
-
-
-
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Receptor protein-tyrosine kinase HEK8
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-
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Receptor protein-tyrosine kinase TKT
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-
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Receptor tyrosine kinase MerTK
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Receptor-activated Janus kinase
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RTK
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SCFR
-
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Slow nerve growth factor receptor
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-
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Stem cell-derived tyrosine kinase
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-
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Torpedo protein
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-
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TRK1 transforming tyrosine kinase protein
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TrkB tyrosine kinase
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-
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TrkC tyrosine kinase
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-
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Tunica interna endothelial cell kinase
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-
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Tyrosine kinase CEK6 receptor
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-
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Tyrosine kinase DDR
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-
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Tyrosine kinase receptor HD-14
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Tyrosine kinase-type cell surface receptor HER2
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-
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Tyrosine kinase-type cell surface receptor HER3
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-
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Tyrosine kinase-type cell surface receptor HER4
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-
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Tyrosine-protein kinase CAK
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-
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Tyrosine-protein kinase CEK9
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-
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Tyrosine-protein kinase DTK
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-
-
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Tyrosine-protein kinase FLT3
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-
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Tyrosine-protein kinase FRT
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-
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Tyrosine-protein kinase receptor CEK10
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-
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Tyrosine-protein kinase receptor CEK11
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-
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Tyrosine-protein kinase receptor CEK5
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Tyrosine-protein kinase receptor CEK7
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-
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Tyrosine-protein kinase receptor CEK8
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-
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Tyrosine-protein kinase receptor CEPHA7
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Tyrosine-protein kinase receptor ECK
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-
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Tyrosine-protein kinase receptor EEK
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Tyrosine-protein kinase receptor EPH
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-
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Tyrosine-protein kinase receptor ESK
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-
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Tyrosine-protein kinase receptor ETK1
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-
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Tyrosine-protein kinase receptor FLT
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-
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Tyrosine-protein kinase receptor FLT3
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-
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Tyrosine-protein kinase receptor FLT4
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-
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Tyrosine-protein kinase receptor HTK
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-
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Tyrosine-protein kinase receptor PAG
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Tyrosine-protein kinase receptor QEK5
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Tyrosine-protein kinase receptor REK4
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Tyrosine-protein kinase receptor SEK
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Tyrosine-protein kinase receptor TCK
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Tyrosine-protein kinase receptor TEK
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Tyrosine-protein kinase receptor XEK
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Tyrosine-protein kinase receptor XELK
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Tyrosine-protein kinase receptor ZEK1
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Tyrosine-protein kinase receptor ZEK2
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Tyrosine-protein kinase receptor ZEK3
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Tyrosine-protein kinase RSE
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-
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Tyrosine-protein kinase SKY
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Vascular permeability factor receptor
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
mast cell tumor cell
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KIT_CANLF
979
2
109753
Swiss-Prot
Secretory Pathway (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
c-Kit mutant, juxtamembrane mutation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ma, Y.; Longley, B.J.; Wang, X.; Blount, J.L.; Langley, K.; Caughey, G.H.
Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms
J. Invest. Dermatol.
112
165-170
1999
Canis lupus familiaris (O97799), Canis lupus familiaris
Manually annotated by BRENDA team
Matsumura, I.; Mizuki, M.; Kanakura, Y.
Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies
Cancer Sci.
99
479-485
2008
Homo sapiens, Mus musculus, Canis lupus familiaris (O97799)
Manually annotated by BRENDA team