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ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + adenosine
ADP + adenosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + guanosine
ADP + guanosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + inosine
ADP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + mizoribine
ADP + mizoribine 5'-phosphate
i.e. 5-hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide. Phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + ribavirin
ADP + ribavirin 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ATP + uridine
ADP + uridine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
CTP + inosine
CDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
GTP + inosine
GDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
ITP + inosine
IDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
TTP + inosine
TDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
UTP + inosine
UDP + inosine 5'-phosphate
phosphate donor specificity in the order of relaltive velocity: ITP (200%), TTP (130%), GTP (125%), ATP (100%), CTP (45%), UTP (40%)
-
-
?
additional information
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additional information
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in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
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-
?
additional information
?
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in the presence of D-ribose, L-ribose, fructose, glucose, 2-deoxy-glucose, xanthosine, galactose, xylose, N-acetyl glucosamine, fructose-6-phosphate, mannose-6-phosphate and ribose-5-phosphate, the activity is below the detection limit. No activity with cytidine or thamidine
-
-
?
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Breast Neoplasms
Adenosine and deoxyadenosine induces apoptosis in oestrogen receptor-positive and -negative human breast cancer cells via the intrinsic pathway.
Herpes Simplex
Herpes simplex virus type 2 induced pyrimidine nucleoside kinase: enzymatic basis for the selective antiherpetic effect of 5-halogenated analogues of deoxycytidine.
Herpes Simplex
Liquid-based iterative recombineering method tolerant to counter-selection escapes.
Herpes Simplex
Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
Herpes Simplex
The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.
Leukemia
Analysis of the in vitro inhibition of murine and human tumor cell growth by pyrazole derivatives and a substituted azabicyclo [3.1.0] hexane-2,4-dione.
Leukemia L1210
Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs.
Neoplasms
Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster.
Neoplasms
Bystander effects of nucleoside analogs phosphorylated in the cytosol or mitochondria.
Neoplasms
Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster.
Neoplasms
Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.
Neoplasms
Metabolism of pyrimidine nucleotides in various tissues and tumor cells from rodents.
Neoplasms
[Effect of hematoporphyrin derivative (HpD) on nucleoside transport and nucleoside kinase activity of cancer cells]
Osteosarcoma
Lipid-mediated protein delivery of suicide nucleoside kinases.
Sarcoma, Avian
Nucleoside kinase activities in tissues infected with Rous sarcoma virus.
thymidine kinase deficiency
Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.
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