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Information on EC 2.7.1.93 - alkylglycerol kinase for references in articles please use BRENDA:EC2.7.1.93Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus
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ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate
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phospho group transfer
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Ether lipid metabolism
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ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase
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1-alkylglycerol kinase (phosphorylating)
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alkylglycerol phosphotransferase
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ATP-alkylglycerol phosphotransferase
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ATP:1-alkyl-sn-glycerol phosphotransferase
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kinase, 1-alkylglycerol (phosphorylating)
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brenda
adult male New Zealand white rabbit
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brenda
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ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
ATP + 1-O-hexadecyl-sn-glycerol
ADP + 1-O-hexadecyl-sn-glycero-3-phosphate
ATP + 1-octadecyl-sn-glycerol
ADP + 1-octadecyl-sn-glycero-3-phosphate
additional information
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ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
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stereospecific for the substrates possessing an sn-1 alkyl chain
formation of 1-alkyl-2-lyso-sn-glycero-3-phosphate
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ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
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stereoselective transfer of the terminal phosphate of ATP to position 3 of the substrate, ATP is an absolute requirement for enzymatic activity
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ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
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involved in the biosynthesis of complex ether-linked glycerolipids
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ATP + 1-O-hexadecyl-sn-glycerol
ADP + 1-O-hexadecyl-sn-glycero-3-phosphate
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ATP + 1-O-hexadecyl-sn-glycerol
ADP + 1-O-hexadecyl-sn-glycero-3-phosphate
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ATP + 1-octadecyl-sn-glycerol
ADP + 1-octadecyl-sn-glycero-3-phosphate
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ATP + 1-octadecyl-sn-glycerol
ADP + 1-octadecyl-sn-glycero-3-phosphate
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additional information
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not: 3-alkyl-sn-glycerols
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not: alkylethylene glycols, only trace activity with 1-thio-hexadecyl-2,3-propanediol
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not: alkylethylene glycols, only trace activity with 1-thio-hexadecyl-2,3-propanediol
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not: S-alkyl-alkylglycerols, 2-hexadecylglycerol, 3-hexadecyl-sn-glycerol, 1-hexadecylethylene glycol
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ATP + 1-alkyl-sn-glycerol
ADP + 1-alkyl-sn-glycero-3-phosphate
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involved in the biosynthesis of complex ether-linked glycerolipids
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Mg2+
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absolute requirement for a divalent metal ion, Mg2+ is most effective
Mn2+
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about 50% as effective as Mg2+ in activation
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little activity with Zn2+, Ba2+, Cu2+, Ca2+, Hg2+, Sn2+, Sr2+, Ni2+, Fe2+, NaCl and KCl
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additional information
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not inhibited by rac-1-hexadecanoylglycerol, rac-1,2-dihexadecanoylglycerol, rac-1-hexadecyl-2-hexadecanoylglycerol or 2-hexadecylglycerol
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7.1
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0.1 M Tris-maleate buffer; no sharp pH optimum
7.1
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no sharp pH optimum
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6.1 - 8.1
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about 66% of maximal activity at pH 6.1 and 8.1
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pink portions of
brenda
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brenda
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brenda
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-20°C, whole microsomal preparation, 0.25 M sucrose, 5 mM dithiothreitol, at least 2 months, stable
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-20°C, whole microsomal preparation, at least 2 months, stable
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nutrition
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enzyme plays a very important role in nutritional experiments, both in vivo and in cell culture, where the intent is either to restore or to increase the cellular levels of ether-linked phospholipids
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Rock, C.O.; Snyder, F.
Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase
J. Biol. Chem.
249
5382-5387
1974
Oryctolagus cuniculus
brenda
Snyder, F.
Alkylglycerol phosphotransferase
Methods Enzymol.
209
211-215
1992
Oryctolagus cuniculus
brenda
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