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Information on EC 2.7.1.93 - alkylglycerol kinase

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EC Tree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.93 alkylglycerol kinase

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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus

Reaction Schemes

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ATP

1-O-alkyl-sn-glycerol

ADP

1-O-alkyl-sn-glycerol 3-phosphate

Synonyms

1-alkylglycerol kinase (phosphorylating), alkylglycerol phosphotransferase, ATP-alkylglycerol phosphotransferase, ATP:1-alkyl-sn-glycerol phosphotransferase, kinase, 1-alkylglycerol (phosphorylating), show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

1-alkylglycerol kinase (phosphorylating)

alkylglycerol phosphotransferase

ATP-alkylglycerol phosphotransferase

ATP:1-alkyl-sn-glycerol phosphotransferase

kinase, 1-alkylglycerol (phosphorylating)

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

phospho group transfer

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Go to Pathway Search

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PATHWAY SOURCE

PATHWAYS

KEGG

Ether lipid metabolism

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SYSTEMATIC NAME

IUBMB Comments

ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase

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CAS REGISTRY NUMBER

COMMENTARY

55354-37-5

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + 1-alkyl-sn-glycerol

ADP + 1-alkyl-sn-glycero-3-phosphate

3 entries

ATP + 1-O-hexadecyl-sn-glycerol

ADP + 1-O-hexadecyl-sn-glycero-3-phosphate

2 entries

ATP + 1-octadecyl-sn-glycerol

ADP + 1-octadecyl-sn-glycero-3-phosphate

2 entries

additional information

4 entries

ATP + 1-alkyl-sn-glycerol

ADP + 1-alkyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

stereospecific for the substrates possessing an sn-1 alkyl chain

642124

formation of 1-alkyl-2-lyso-sn-glycero-3-phosphate

642124

ATP + 1-alkyl-sn-glycerol

ADP + 1-alkyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

stereoselective transfer of the terminal phosphate of ATP to position 3 of the substrate, ATP is an absolute requirement for enzymatic activity

642123

ATP + 1-alkyl-sn-glycerol

ADP + 1-alkyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

involved in the biosynthesis of complex ether-linked glycerolipids

642123

ATP + 1-O-hexadecyl-sn-glycerol

ADP + 1-O-hexadecyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

642123

ATP + 1-O-hexadecyl-sn-glycerol

ADP + 1-O-hexadecyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

642124

ATP + 1-octadecyl-sn-glycerol

ADP + 1-octadecyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

642123

ATP + 1-octadecyl-sn-glycerol

ADP + 1-octadecyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

642124

additional information

Oryctolagus cuniculus

not: 3-alkyl-sn-glycerols

642124

additional information

Oryctolagus cuniculus

not: alkylethylene glycols, only trace activity with 1-thio-hexadecyl-2,3-propanediol

642123

additional information

Oryctolagus cuniculus

not: alkylethylene glycols, only trace activity with 1-thio-hexadecyl-2,3-propanediol

642124

additional information

Oryctolagus cuniculus

not: S-alkyl-alkylglycerols, 2-hexadecylglycerol, 3-hexadecyl-sn-glycerol, 1-hexadecylethylene glycol

642123

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + 1-alkyl-sn-glycerol

ADP + 1-alkyl-sn-glycero-3-phosphate

Oryctolagus cuniculus

involved in the biosynthesis of complex ether-linked glycerolipids

642123

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Mg2+

Oryctolagus cuniculus

absolute requirement for a divalent metal ion, Mg2+ is most effective

642123

Mn2+

Oryctolagus cuniculus

about 50% as effective as Mg2+ in activation

642123

additional information

Oryctolagus cuniculus

little activity with Zn2+, Ba2+, Cu2+, Ca2+, Hg2+, Sn2+, Sr2+, Ni2+, Fe2+, NaCl and KCl

642123

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

additional information

Oryctolagus cuniculus

not inhibited by rac-1-hexadecanoylglycerol, rac-1,2-dihexadecanoylglycerol, rac-1-hexadecyl-2-hexadecanoylglycerol or 2-hexadecylglycerol

642123

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.6

ATP

Oryctolagus cuniculus

642123

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

7.1

2 entries

7.1

Oryctolagus cuniculus

0.1 M Tris-maleate buffer

642123

7.1

Oryctolagus cuniculus

no sharp pH optimum

642123, 642124

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6.1 - 8.1

Oryctolagus cuniculus

about 66% of maximal activity at pH 6.1 and 8.1

642123, 642124

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TEMPERATURE OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Oryctolagus cuniculus

assay at

642123, 642124

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Oryctolagus cuniculus

2 entries

Oryctolagus cuniculus

642124

brenda

Oryctolagus cuniculus

adult male New Zealand white rabbit

642123

brenda

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

harderian gland

2 entries

harderian gland

Oryctolagus cuniculus

642124

brenda

harderian gland

Oryctolagus cuniculus

pink portions of

642123

brenda

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LOCALIZATION

ORGANISM

UNIPROT

COMMENTARY

GeneOntology No.

LITERATURE

SOURCE

microsome

Oryctolagus cuniculus

642123, 642124

brenda

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-20°C, whole microsomal preparation, 0.25 M sucrose, 5 mM dithiothreitol, at least 2 months, stable

Oryctolagus cuniculus

642123

-20°C, whole microsomal preparation, at least 2 months, stable

Oryctolagus cuniculus

642124

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

partial

Oryctolagus cuniculus

642123, 642124

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

nutrition

Oryctolagus cuniculus

enzyme plays a very important role in nutritional experiments, both in vivo and in cell culture, where the intent is either to restore or to increase the cellular levels of ether-linked phospholipids

642124

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID