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Information on EC 2.7.1.85 - beta-glucoside kinase
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2.7.1.85 beta-glucoside kinaseIUBMB Comments
Phosphorylates a number of beta-D-glucosides; GTP, CTP, ITP and UTP can also act as donors.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
beta-glucoside kinase, beta-glucoside (cellobiose):phosphotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
beta-glucoside (cellobiose):phosphotransferase
-
-
-
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beta-glucoside kinase
-
-
-
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BglK
-
-
-
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kinase, beta-D-glucoside (phosphorylating)
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1->4)-D-glucose
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:cellobiose 6-phosphotransferase
Phosphorylates a number of beta-D-glucosides; GTP, CTP, ITP and UTP can also act as donors.
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CAS REGISTRY NUMBER
COMMENTARY
37205-53-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + cellotetraose
ADP + 6-phospho-beta-glucosyl-(1,4)-beta-D-glucosyl-(1,4)-beta-D-glucosyl-(1,4)-D-glucose
ATP + cellotriose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-beta-D-glucosyl-(1,4)-D-glucose
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47% of the activity with cellobiose
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-
?
ATP + isopropyl beta-D-thioglucopyranoside
ADP + isopropyl beta-D-thioglucopyranoside 6-phosphate
-
-
-
-
?
ATP + laminaribiose
ADP + 6-phospho-beta-D-glucopyranosyl-(1,3)-D-glucose
-
-
-
-
?
ATP + n-octyl-beta-D-glucopyranoside
ADP + n-octyl-beta-D-glucopyranoside 6-phosphate
-
-
-
-
?
CTP + cellobiose
CDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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12% of the activity with ATP
-
?
GTP + cellobiose
GDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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15% of the activity with ATP
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?
ITP + cellobiose
IDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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7% of the activity with ATP
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?
UTP + cellobiose
UDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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3% of the activity with ATP
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-
?
additional information
?
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not: ADP, acetyl phosphate, alpha-glycerophosphate, D-fructose, 1,6-diphosphate, phosphoramidate, choline phosphate, creatine phosphate, 3-phosphoglycerate, phenylphosphate, phosphoenolpyruvate
-
-
?
ATP + amygdalin
ADP + amygdalin 6-phosphate
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21% of the activity with cellobiose
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-
?
ATP + arbutin
ADP + arbutin 6-phosphate
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36% of the activity with cellobiose
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-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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-
-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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-
-
-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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first reaction in metabolism of cellobiose, inducible enzyme
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-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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inducible enzyme that functions in metabolism of cellobiose and gentiobiose
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-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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-
-
-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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-
-
-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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-
-
-
?
ATP + cellotetraose
ADP + 6-phospho-beta-glucosyl-(1,4)-beta-D-glucosyl-(1,4)-beta-D-glucosyl-(1,4)-D-glucose
-
-
-
-
?
ATP + cellotetraose
ADP + 6-phospho-beta-glucosyl-(1,4)-beta-D-glucosyl-(1,4)-beta-D-glucosyl-(1,4)-D-glucose
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33% of the activity with cellobiose
-
-
?
ATP + gentiobiose
ADP + 6-phospho-beta-D-glucosyl-(1,6)-D-glucose
-
-
-
?
ATP + gentiobiose
ADP + 6-phospho-beta-D-glucosyl-(1,6)-D-glucose
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70% of the activity with cellobiose
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-
?
ATP + gentiobiose
ADP + 6-phospho-beta-D-glucosyl-(1,6)-D-glucose
-
inducible enzyme that functions in metabolism of cellobiose and gentiobiose
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-
?
ATP + gentiobiose
ADP + 6-phospho-beta-D-glucosyl-(1,6)-D-glucose
-
-
-
-
?
ATP + methyl beta-D-glucoside
ADP + methyl beta-D-glucoside 6-phosphate
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-
-
-
?
ATP + methyl beta-D-glucoside
ADP + methyl beta-D-glucoside 6-phosphate
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as active as cellobiose
-
-
?
ATP + methyl beta-D-glucoside
ADP + methyl beta-D-glucoside 6-phosphate
-
-
-
-
?
ATP + phenyl beta-D-glucoside
ADP + phenyl beta-D-glucoside 6-phosphate
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-
-
-
?
ATP + phenyl beta-D-glucoside
ADP + phenyl beta-D-glucoside 6-phosphate
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70% of the activity with cellobiose
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-
?
ATP + phenyl beta-D-glucoside
ADP + phenyl beta-D-glucoside 6-phosphate
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-
-
-
?
ATP + salicin
ADP + salicin 6-phosphate
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87% of the activity with cellobiose
-
-
?
ATP + sophorose
ADP + 6-phospho-beta-D-glucopyranosyl-(1,2)-D-glucose
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-
-
-
?
ATP + sophorose
ADP + 6-phospho-beta-D-glucopyranosyl-(1,2)-D-glucose
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19% of the activity with cellobiose
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-
?
ATP + sophorose
ADP + 6-phospho-beta-D-glucopyranosyl-(1,2)-D-glucose
-
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + gentiobiose
ADP + 6-phospho-beta-D-glucosyl-(1,6)-D-glucose
-
inducible enzyme that functions in metabolism of cellobiose and gentiobiose
-
-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
-
first reaction in metabolism of cellobiose, inducible enzyme
-
-
?
ATP + cellobiose
ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
-
inducible enzyme that functions in metabolism of cellobiose and gentiobiose
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.2 - 8.2
-
pH 6.2: about 60% of maximal activity in Mes buffer, pH 8.2: reaction in PIPES buffer, about 70% of maximal activity in MES buffer
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Show AA Sequence and Transmembrane Helices (899 entries)
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
32000
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
tetramer
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Palmer, R.E.; Anderson, R.L.
Cellobiose metabolism in Aerobacter aerogenes. II. Phosphorylation of cellobiose with adenosine 5-triphosphate by alpha-glucoside kinase
J. Biol. Chem.
247
3415-3419
1972
Klebsiella aerogenes
brenda
Anderson, R.L.; Palmer, R.E.
Cellobiose metabolism in Aerobacter aerogenes
Methods Enzymol.
42 C
3-6
1975
Klebsiella aerogenes
-
brenda
Thompson, J.; Lichtenthaler, F.W.; Peters, S.; Pikis, A.
beta-Glucoside kinase (BglK) from Klebsiella pneumoniae. Purification, properties, and preparative synthesis of 6-phospho-beta-D-glucosides
J. Biol. Chem.
277
34310-34321
2002
Klebsiella pneumoniae, Listeria innocua, Listeria monocytogenes, Listeria innocua CLIP 11262
brenda
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Release 2023.1 (January 2023)
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