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The expected taxonomic range for this enzyme is: Propionibacterium freudenreichii subsp. shermanii
Synonyms
phosphotransferase, pyrophosphate-serine, pyrophosphate-L-serine phosphotransferase, pyrophosphate-serine phosphotransferase, pyrophosphate:L-serine O-phosphotransferase, pyrophosphate:L-serine phosphotransferase,
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phosphotransferase, pyrophosphate-serine
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pyrophosphate-L-serine phosphotransferase
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pyrophosphate-serine phosphotransferase
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pyrophosphate:L-serine O-phosphotransferase
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pyrophosphate:L-serine phosphotransferase
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diphosphate + L-serine = phosphate + O-phospho-L-serine
diphosphate + L-serine = phosphate + O-phospho-L-serine
binary or ping-pong mechanism
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diphosphate + L-serine = phosphate + O-phospho-L-serine
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phospho group transfer
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diphosphate:L-serine O-phosphotransferase
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diphosphate + alpha-methylserine
phosphate + alpha-methyl-O-phospho-L-serine
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7% activity compared to L-serine
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diphosphate + DL-homoserine
phosphate + O-phospho-DL-homoserine
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7% activity compared to L-serine
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diphosphate + glycyl-L-serine
phosphate + glycyl-O-phospho-L-serine
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16% activity compared to L-serine
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diphosphate + L-serine
phosphate + O-phospho-L-serine
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diphosphate + L-threonine
phosphate + O-phospho-L-threonine
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8% activity compared to L-serine
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diphosphate + N-chloroacetyl-L-serine
phosphate + N-chloroacetyl-O-phospho-L-serine
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19% activity compared to L-serine
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additional information
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additional information
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substrate specificity
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additional information
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no activity with D-serine and L-cysteine, tripolyphosphate can substitute to some extent for diphosphate
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diphosphate + L-serine
phosphate + O-phospho-L-serine
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Ba2+
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slight stimulation, about 14% of activity compared to Mg2+
Co2+
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slight stimulation, about 42% of activity compared to Mg2+
Cu2+
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slight stimulation, about 14% of activity compared to Mg2+
Mn2+
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slight stimulation, about 34% of activity compared to Mg2+
Zn2+
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slight stimulation, about 14% of activity compared to Mg2+
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Ca2+
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50% inhibition at 1 mM
Cd2+
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65% inhibition at 1 mM
D-serine
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20 mM, weak inhibition
DL-homoserine
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100 mM, weak inhibition
EDTA
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inpresence of phosphate
glycerol
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100 mM, weak inhibition
glycine
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20% inhibition at 10 mM
Glycyl-L-serine
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weak inhibition
Hg2+
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55% inhibition at 1 mM
L-alanine
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35% inhibition at 10 mM
L-threonine
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100 mM, weak inhibition
La3+
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25% inhibition at 1 mM
Tris
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0.6 M, weak inhibition
Zn2+
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85% inhibition at 10 mM
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0.1
diphosphate
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pH 7.8, 37°C
1.9
L-serine
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pH 7.8, 37°C
0.13
Mg2+
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1 mM diphosphate, pH 7.8, 37°C
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0.8
glycine
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pH 7.8, 37°C
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9.5
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partially purified enzyme
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5.4 - 7.8
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60% of maximal activity at pH 5.4 and pH 7.8
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strain ATCC 9614
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brenda
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30
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stable at least 12 h
65
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15 min, 46% remaining activity
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4°C o r-15°C, 0.02 M Tris buffer, pH 7.8, stable for several weeks
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Cagen, L.M.; Friedmann, H.C.
Enzymatic phosphorylation of serine
J. Biol. Chem.
247
3382-3392
1972
Propionibacterium freudenreichii subsp. shermanii
brenda
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