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ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
-
20% of the activity with D-mannose
-
-
?
ATP + 2-deoxy-D-mannose
ADP + 2-deoxy-D-mannose 6-phosphate
ATP + D-fructose
ADP + D-fructose 6-phosphate
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
-
5% of the activity with D-mannose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
ATP + D-mannosamine
ADP + D-mannosamine 6-phosphate
-
15% of the activity with D-mannose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
ATP + D-mannose
ADP + mannose 6-phosphate
ATP + mannoheptulose
ADP + mannoheptulose 6-phosphate
CTP + 2-deoxy-D-mannose
CDP + 2-deoxy-D-mannose 6-phosphate
-
-
-
-
?
CTP + D-glucose
CDP + D-glucose 6-phosphate
-
-
-
-
?
CTP + D-mannosamine
CDP + D-mannosamine 6-phosphate
-
-
-
-
?
CTP + D-mannose
CDP + D-mannose 6-phosphate
CTP + mannoheptulose
CDP + mannoheptulose 6-phosphate
-
-
-
-
?
dATP + D-mannose
dADP + D-mannose 6-phosphate
-
-
-
-
?
GTP + 2-deoxy-D-mannose
GDP + 2-deoxy-D-mannose 6-phosphate
-
-
-
-
?
GTP + D-glucose
GDP + D-glucose 6-phosphate
-
-
-
-
?
GTP + D-mannosamine
GDP + D-mannosamine 6-phosphate
-
-
-
-
?
GTP + D-mannose
GDP + D-mannose 6-phosphate
GTP + mannoheptulose
GDP + mannoheptulose 6-phosphate
-
-
-
-
?
hexametaphosphate + D-mannose
pentaphosphate + D-mannose 6-phosphate
ITP + 2-deoxy-D-mannose
IDP + 2-deoxy-D-mannose 6-phosphate
-
-
-
-
?
ITP + D-glucose
IDP + D-glucose 6-phosphate
-
-
-
-
?
ITP + D-mannosamine
IDP + D-mannosamine 6-phosphate
-
-
-
-
?
ITP + D-mannose
IDP + D-mannose 6-phosphate
ITP + mannoheptulose
IDP + mannoheptulose 6-phosphate
-
-
-
-
?
TTP + D-mannose
TDP + D-mannose 6-phosphate
-
30% of the activity with ATP
-
-
?
UTP + D-mannose
UDP + D-mannose 6-phosphate
additional information
?
-
ATP + 2-deoxy-D-mannose
ADP + 2-deoxy-D-mannose 6-phosphate
-
no activity
-
-
?
ATP + 2-deoxy-D-mannose
ADP + 2-deoxy-D-mannose 6-phosphate
-
25% of the activity with D-mannose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
D-mannose and D-fructose phosphorylated equally well
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
D-mannose and D-fructose phosphorylated equally well
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
enzyme initiates the metabolism of D-fructose and D-mannose
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
no activity
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
no activity
-
-
?
ATP + D-fructose
ADP + D-fructose 6-phosphate
-
reaction is catalyzed by a separate enzyme, EC 2.7.1.4
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
50% of the activity with D-mannose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
no activity with D-glucose or L-glucose
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
80% of the activity with D-mannose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
enzyme initiates the metabolism of D-fructose and D-mannose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
enzyme is involved in the catabolic pathway of D-mannose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
enzyme is involved in the catabolic pathway of D-mannose
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
inducible enzyme
-
-
?
ATP + D-mannose
ADP + mannose 6-phosphate
-
-
-
?
ATP + D-mannose
ADP + mannose 6-phosphate
-
D-mannose and D-fructose phosphorylated equally well
D-mannose 6-phosphate
?
ATP + D-mannose
ADP + mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + mannose 6-phosphate
-
-
-
-
?
ATP + D-mannose
ADP + mannose 6-phosphate
-
highly specific for D-mannose
-
?
ATP + D-mannose
ADP + mannose 6-phosphate
-
-
-
-
?
ATP + mannoheptulose
ADP + mannoheptulose 6-phosphate
-
no activity
-
-
?
ATP + mannoheptulose
ADP + mannoheptulose 6-phosphate
-
10% of the activity with D-mannose
-
-
?
CTP + D-mannose
CDP + D-mannose 6-phosphate
-
15% of the activity with ATP
-
-
?
CTP + D-mannose
CDP + D-mannose 6-phosphate
-
no activity
-
-
?
CTP + D-mannose
CDP + D-mannose 6-phosphate
-
10% of the activity with ATP
-
-
?
GTP + D-mannose
GDP + D-mannose 6-phosphate
-
60% of the activity with ATP
-
-
?
GTP + D-mannose
GDP + D-mannose 6-phosphate
-
10% of the activity with ATP
-
-
?
GTP + D-mannose
GDP + D-mannose 6-phosphate
-
40% of the activity with ATP
-
-
?
hexametaphosphate + D-mannose
pentaphosphate + D-mannose 6-phosphate
-
-
-
?
hexametaphosphate + D-mannose
pentaphosphate + D-mannose 6-phosphate
-
-
-
?
ITP + D-mannose
IDP + D-mannose 6-phosphate
-
as active as ATP
-
-
?
ITP + D-mannose
IDP + D-mannose 6-phosphate
-
15% of the activity with ATP
-
-
?
ITP + D-mannose
IDP + D-mannose 6-phosphate
-
90% of the activity with ATP
-
-
?
UTP + D-mannose
UDP + D-mannose 6-phosphate
-
60% of the activity with ATP
-
-
?
UTP + D-mannose
UDP + D-mannose 6-phosphate
-
no activity
-
-
?
additional information
?
-
enzyme is also active with D-glucose, which is a more efficient substrate than D-mannose, ratio 3:2 and 3:1 with ATP and polyphosphate, respectively
-
-
?
additional information
?
-
-
enzyme is also active with D-glucose, which is a more efficient substrate than D-mannose, ratio 3:2 and 3:1 with ATP and polyphosphate, respectively
-
-
?
additional information
?
-
enzyme is also active with D-glucose, which is a more efficient substrate than D-mannose, ratio 3:2 and 3:1 with ATP and polyphosphate, respectively
-
-
?
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Cu2+
activates, 11% activity with polyphosphate compared to Mg2+, no activity with ATP
Fe2+
activates, 15% activity with ATP compared to Mg2+, no activity with polyphosphate
Ni2+
-
40% of the activity with Mg2+
Zn2+
activates, 80% and 19% activity with polyphosphate and ATP, respectively, compared to Mg2+
Co2+
activates, 86% and 30% activity with polyphosphate and ATP, respectively, compared to Mg2+
Co2+
-
can partially replace Mg2+
Co2+
-
activates with 40% of the activity with Mg2+
Mg2+
absolutely required, most effective metal ion
Mg2+
-
optimal Mg2+/ATP ratio is 1
Mg2+
-
optimal Mg2+/ATP ratio is 2
Mn2+
activates, 82% and 88% activity with polyphosphate and ATP, respectively, compared to Mg2+
Mn2+
-
can partially replace Mg2+
Mn2+
-
activates with 25% of the activity with Mg2+
additional information
activities with different divalent cations in descending order: Mg2+, Mn2+, Co2+, Zn2+, Cu2+, and Fe2+, no activity with Hg2+
additional information
-
activities with different divalent cations in descending order: Mg2+, Mn2+, Co2+, Zn2+, Cu2+, and Fe2+, no activity with Hg2+
additional information
-
no activation with Ca2+, Sn2+, Cd2+
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Anderson, R.L.; Sapico, V.L.
D-fructose (D-mannose) kinase
Methods Enzymol.
42C
39-43
1975
Leuconostoc mesenteroides
-
brenda
Mukai, T.; Kawai, S.; Matsukawa, H.; Matuo, Y.; Murata, K.
Characterization and molecular cloning of a novel enzyme, inorganic polyphosphate/ATP-glucomannokinase, of Arthrobacter sp. strain KM
Appl. Environ. Microbiol.
69
3849-3857
2003
Arthrobacter sp. (Q7WT42), Arthrobacter sp., Arthrobacter sp. KM (Q7WT42)
brenda
Gardiol, A.A.A.; Martinez-Drets, G.
Transport and catabolism of D-mannose in Rhizobium meliloti
J. Bacteriol.
151
1069-1072
1982
Sinorhizobium meliloti, Sinorhizobium meliloti L5-30
brenda
Sabater, B.; Sebastian, J.; Asensio, C.
Identification and properties of an inducible mannokinase from Streptomyces violaceoruber
Biochim. Biophys. Acta
284
406-413
1972
Streptomyces violaceoruber
brenda
Coulombel, C.; Foglietti, M.J.; Percheron, F.
Identification and kinetic studies of an inducible mannokinase from a Streptomyces strain
Biochim. Biophys. Acta
706
117-122
1982
Streptomyces sp.
brenda
Sebastian, J.; Asensio, C.
Purification and properties of the mannokinase from Escherichia coli
Arch. Biochem. Biophys.
151
227-233
1972
Escherichia coli
brenda