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Information on EC 2.7.1.52 - fucokinase and Organism(s) Homo sapiens and UniProt Accession Q8N0W3

for references in articles please use BRENDA:EC2.7.1.52
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EC Tree
IUBMB Comments
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
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This record set is specific for:
Homo sapiens
UNIPROT: Q8N0W3
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fucokinase, l-fucokinase, fucose kinase, l-fucose kinase, fucokinase/l-fucose-1-p-guanylyltransferase, l-fucokinase:gdp-fucose pyrophosphorylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
fucokinase
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fucose kinase
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kinase, fuco- (phosphorylating)
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L-fucose kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:beta-L-fucose 1-phosphotransferase
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-00-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 6-deoxy-L-galactose
ADP + 6-deoxy-L-galactose 1-phosphate
show the reaction diagram
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Uniprot
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FCSK_HUMAN
1084
0
117623
Swiss-Prot
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
110000
x * 110000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 110000, SDS-PAGE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of full-length protein and a deletion mutant lacking the first 363 amino acids of the N-terminus are expressed in Escherichia coli BL21 cells. Both proteins display fucokinase activity. Identification of amino acid sequence
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hinderlich, S.; Berger, M.; Blume, A.; Chen, H.; Ghaderi, D.; Bauer, C.
Identification of human L-fucose kinase amino acid sequence
Biochem. Biophys. Res. Commun.
294
650-654
2002
Homo sapiens (Q8N0W3), Homo sapiens
Manually annotated by BRENDA team