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Information on EC 2.7.1.52 - fucokinase and Organism(s) Mus musculus and UniProt Accession Q7TMC8

for references in articles please use BRENDA:EC2.7.1.52
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EC Tree
IUBMB Comments
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
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This record set is specific for:
Mus musculus
UNIPROT: Q7TMC8
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fucokinase, l-fucokinase, fucose kinase, l-fucose kinase, fucokinase/l-fucose-1-p-guanylyltransferase, l-fucokinase:gdp-fucose pyrophosphorylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ATP:6-deoxy-beta-L-galactose 1-phosphotransferase
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L-fucokinase
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ATP:6-deoxy-beta-L-galactose 1-phosphotransferase
fucokinase
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fucose kinase
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kinase, fuco- (phosphorylating)
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L-fucose kinase
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additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:beta-L-fucose 1-phosphotransferase
Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-00-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + L-fucose
ADP + beta-L-fucose 1-phosphate
show the reaction diagram
ATP + L-fucose
ADP + beta-L-fucose 1-phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + L-fucose
ADP + beta-L-fucose 1-phosphate
show the reaction diagram
involved in GDP-L-fucose salvage pathway
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-
?
ATP + L-fucose
ADP + beta-L-fucose 1-phosphate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
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Manually annotated by BRENDA team
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very low enzyme level
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FCSK_MOUSE
1090
0
119267
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
120000
long splicing variant
111000
short splicing variant
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
two different transcripts of 3057 and 3270 base pairs expressed in COS-7 cells, only the longer splice variant is enzymatically active
two different transcripts of 3057 and 3270 base pairs expressed in COS-7 cells, only the longer splice variant is enzymatically active
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miller, E.N.; Rupp, A.L.; Lindberg, M.K.; Wiese, T.J.
Tissue distribution of L-fucokinase in rodents
Comp. Biochem. Physiol. B
140
513-520
2005
Mus musculus, Rattus rattus
Manually annotated by BRENDA team
Niittymaki, J.; Mattila, P.; Roos, C.; Huopaniemi, L.; Sjoblom, S.; Renkonen, R.
Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose
Eur. J. Biochem.
271
78-86
2004
Mus musculus (Q7TMC8), Mus musculus (Q7TS31), Mus musculus
Manually annotated by BRENDA team
Niittymaki, J.; Mattila, P.; Renkonen, R.
Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII
APMIS
114
539-548
2006
Rattus norvegicus, Mus musculus (Q7TMC8), Mus musculus
Manually annotated by BRENDA team