Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 2.7.1.48 - uridine/cytidine kinase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Preliminary studies of the uridine kinase activity of human colorectal adenocarcinomas.
Adenosarcoma
Uridine kinase activity in human tumors.
Breast Neoplasms
Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis.
Carcinoid Tumor
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma
Enzyme pathology of human mesotheliomas.
Increased uridine kinase (ATP: uridine 5'-phosphotransferase; EC 2.7.1.48) activity in human and rat tumors.
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Specific activities of uridine phosphorylase and uridine kinase in Ehrlich ascites carcinoma cells and 6-azauracil- and 6-azauridine-treated sublines in successive transplant generations.
Uridine kinase from Ehrlich ascites carcinoma. Purification and properties of homogeneous enzyme.
Uridine phosphorylase and uridine kinase activities of the Ehrlich ascites carcinoma.
Carcinoma, Ehrlich Tumor
Homogeneous uridine kinase from Ehrlich ascites tumor: substrate specificity and inhibition by bisubstrate analogs.
Regulation of uridine kinase. Evidence for a regulatory site.
The partial purification and properties of uridine kinase from Ehrlich ascites tumor cells.
Uridine kinase from Ehrlich ascites carcinoma. Purification and properties of homogeneous enzyme.
Carcinoma, Hepatocellular
Expression Levels of the Uridine-Cytidine Kinase Like-1 Protein As a Novel Prognostic Factor for Hepatitis C Virus-Associated Hepatocellular Carcinomas.
Increased uridine kinase (ATP: uridine 5'-phosphotransferase; EC 2.7.1.48) activity in human and rat tumors.
Relationship between uridine kinase activity and rate of incorporation of uridine into acid-soluble pool and into RNA during growth cycle of rat hepatoma cells.
UCK2 upregulation might serve as an indicator of unfavorable prognosis of hepatocellular carcinoma.
Uridine kinase molecular species and uridine uptake in some variants of rat hepatomas.
Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.
Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.
[Enzymes of anabolic and catabolic nucleic acid pathways in human hepatomas, in liver of healthy persons, and in liver of patients with cancer of gastrointestinal tract]
[Isolation and properties or uridine kinase from Zajdela hepatoma cells]
Carcinoma, Squamous Cell
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Cryptorchidism
Cellular distribution, developmental changes and effects of cryptorchidism on uridine kinase in the rat testis.
Encephalomyelitis, Western Equine
Uridine kinase level in cells infected with western equine encephalomyelitis, vesicular stomatitis, pseudorabies and polyoma viruses.
Fibrosarcoma
Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells.
Hepatitis C
Expression Levels of the Uridine-Cytidine Kinase Like-1 Protein As a Novel Prognostic Factor for Hepatitis C Virus-Associated Hepatocellular Carcinomas.
Hyperthyroidism
Effects of thyroid hormone on UTP content and uridine kinase activity of rat heart and skeletal muscle.
Thyroxine effect upon activity of uridine kinase in developing rat cerebellum.
Hypothyroidism
Effect of hypothyroidism on aspartate transcarbamylase, uridine kinase, and DNA biosynthesis during cerebellar development in the rat.
Infections
Changes in the activities of nucleoside triphosphatases and nucleoside kinases in Vero cells infected with Simian virus 40.
EFFECTS OF AGE OF CULTURE AND VACCINIA INFECTION ON URIDINE KINASE ACTIVITY OF L-CELLS.
Increase of uridine kinase activity in Escherichia coli B following T2-phage infection or chloramphenicol treatment.
Overexpression of Escherichia coli udk mimics the absence of T7 Gp2 function and thereby abrogates successful infection by T7 phage.
Leukemia
Biological effects of 5-azacytidine in eukaryotes.
Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells.
Properties of uridine-cytidine kinase derived from L1210 leukemia cells.
Uridine kinase activities in normal and neoplastic lymphoid cells.
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
Leukemia, Lymphocytic, Chronic, B-Cell
Uridine kinase activities in normal and neoplastic lymphoid cells.
Leukemia, Lymphoid
Uridine kinase activities in normal and neoplastic lymphoid cells.
Liver Neoplasms, Experimental
Early temporal changes in the uridine kinase isozyme profile of the Novikoff hepatoma in response to 5-azacytidine treatment.
Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma.
Lung Neoplasms
Uridine kinase, adenylate kinase, and guanase in human lung tumors.
Uridine-cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer.
Lymphoma
Some properties of uridine-cytidine kinase from a human malignant lymphoma.
Lymphoma, Non-Hodgkin
Uridine kinase activities in normal and neoplastic lymphoid cells.
Mastocytoma
Uridine kinase activities in normal and neoplastic lymphoid cells.
Melanoma
METTL3-induced UCK2 m6A hypermethylation promotes melanoma cancer cell metastasis via the WNT/?-catenin pathway.
Mesothelioma
Enzyme pathology of human mesotheliomas.
Neoplasm Metastasis
METTL3-induced UCK2 m6A hypermethylation promotes melanoma cancer cell metastasis via the WNT/?-catenin pathway.
Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.
Neoplasms
A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma.
Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissues.
Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.
Coprecipitation of active uridine kinase and phosphomonoesterase from rat kidney by Zn2+-ions. III. Enzymes relevant to cancer chemotherapy.
Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells.
Cyclopentenyl uracil: an effective inhibitor of uridine salvage in vivo.
Determination of uridine kinase activity in some human tumours and in leucaemic cells using 4,5-C-14--azauridine as substrate.
Determination of uridine kinase activity in some human tumours and normal tissues, using 4,5-14-C-6-azauridine as substrate.
Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells.
Enzyme pathology and the histologic categorization of human lung tumors: the continuum of quantitative biochemical indices of neoplasticity.
Enzyme-Driven Chemo-and Radiation-Therapy with 12 Pyrimidine Nucleoside Analogs Not Yet in the Clinic.
Enzymes relevant to cancer chemotherapy II. Heterogeneity of rat kidney uridine kinase following chromatography on Sepharose 6B coupled to N4-(5-amino-Pentyl)-cytidine.
Homogeneous uridine kinase from Ehrlich ascites tumor: substrate specificity and inhibition by bisubstrate analogs.
In Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica.
Increased uridine kinase (ATP: uridine 5'-phosphotransferase; EC 2.7.1.48) activity in human and rat tumors.
Inhibition of Newcastle disease virus replication by 6-azauridine. I. Inefficacy of purified uridine kinase, effect of adenosine-5'-triphosphate.
Involvement of the uridine cytidine kinase 2 enzyme in cancer cell death: A molecular crosstalk between the enzyme and cellular apoptosis induction.
Preliminary studies of the uridine kinase activity of human colorectal adenocarcinomas.
Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor.
Regulation of uridine kinase. Evidence for a regulatory site.
Role of the uridine/cytidine kinase 2 mutation in cellular sensitiveness toward 3'-ethynylcytidine treatment of human cancer cells.
Role of uridine phosphorylase in the anabolism of 5-fluorouracil.
RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.
Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2.
Synthesis and biologic study of IV-14, a new ribonucleoside radiotracer for tumor visualization.
The partial purification and properties of uridine kinase from Ehrlich ascites tumor cells.
UCK2 upregulation might serve as an indicator of unfavorable prognosis of hepatocellular carcinoma.
Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma.
Uridine kinase activities in normal and neoplastic lymphoid cells.
Uridine kinase activity in human tumors.
Uridine kinase from Ehrlich ascites carcinoma. Purification and properties of homogeneous enzyme.
Uridine kinase, adenylate kinase, and guanase in human lung tumors.
Uridine-cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer.
Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.
Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.
Uridine-cytidine kinase from a murine neoplasm.
Uridine-cytidine kinase from Novikoff ascites rat tumor and Bacillus stearothermophilus.
Uridine-cytidine kinase. Purification from a murine neoplasm and characterization of the enzyme.
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
[Influence on 5-fluorouracil metabolism by combination of interferon-alpha and 5-fluorouracil against human hepatocellular carcinoma xenografts]
Neuroblastoma
Adverse effects of hyperbaric oxygen on [3H]uridine incorporation and uridine kinase activity in B104 rat neuroblastoma cells.
Purification, activity, and expression levels of two uridine-cytidine kinase isoforms in neuroblastoma cell lines.
Newcastle Disease
Inhibition of Newcastle disease virus replication by 6-azauridine. I. Inefficacy of purified uridine kinase, effect of adenosine-5'-triphosphate.
Pancreatic Neoplasms
Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer.
Pseudorabies
Uridine kinase level in cells infected with western equine encephalomyelitis, vesicular stomatitis, pseudorabies and polyoma viruses.
Sarcoma
Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma.
[Uridine-cytidine kinase isoenzymes of rat sarcoma M-1]
Sarcoma, Avian
Induction of deoxycytidylate deaminase and uridine kinase and activation of cellular DNA synthesis in the course of transformation of chicken embryo cells infected by Rous sarcoma virus in vitro.
Sarcoma, Yoshida
Intracellular distribution of various enzymes concerned with DNA synthesis from normal and regenerating rat liver, and Yoshida sarcoma.
Starvation
Appropriate leucine supplementation promotes glucose metabolism and enhances energy homeostasis in juvenile crucian carp (Carassius auratus gibelio var. CAS III).
Uridine kinase activities in developing, adult and neoplastic rat tissues.
Stroke
Nifedipine and nimodipine competitively inhibit uridine kinase and orotidine-phosphate decarboxylase: theoretical relevance to poor outcome in stroke.
Urinary Bladder Neoplasms
Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer.
Vaccinia
EFFECTS OF AGE OF CULTURE AND VACCINIA INFECTION ON URIDINE KINASE ACTIVITY OF L-CELLS.
Vesicular Stomatitis
Uridine kinase level in cells infected with western equine encephalomyelitis, vesicular stomatitis, pseudorabies and polyoma viruses.