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Information on EC 2.7.1.36 - mevalonate kinase and Organism(s) Mus musculus and UniProt Accession Q9R008

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IUBMB Comments
CTP, GTP and UTP can also act as donors.
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This record set is specific for:
Mus musculus
UNIPROT: Q9R008
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mevalonate kinase, mvk, mva kinase, tcmvk, temvk, mevalonic kinase, mevalonate 5-phosphotransferase, atp:mevalonate 5-phosphotransferase, mevalonic acid kinase, atp mevalonate 5-phosphotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ATP:mevalonate 5-phosphotransferase
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kinase, mevalonate (phosphorylating)
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mevalonate 5-phosphotransferase
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mevalonate phosphokinase
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mevalonic acid kinase
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mevalonic kinase
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MVA kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:(R)-mevalonate 5-phosphotransferase
CTP, GTP and UTP can also act as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-52-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + (R)-mevalonate
ADP + (R)-5-phosphomevalonate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + (R)-mevalonate
ADP + (R)-5-phosphomevalonate
show the reaction diagram
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a step in the production of farnesyldiphosphate and geranylgeranyl diphosphate, overview
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
testosterone
treatment of meibomian gland stimulates a significant increase in the mRNA levels of mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase, isopentenyl diphosphate isomerase, geranylgeranyl diphosphate synthase, squalene epoxidase, lanosterol synthase, lanosterol demethylase, and DELTA7-sterol reductase
atorvastatin
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besides increases in mRNA level of HMG CoA reductase, treatment increases hepatic mRNA levels of both mevalonate kinase and cob(I)alamin adenosyltransferase
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
from castrated mice. Treatment with androgens may promote cholesterol biosynthesis
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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highest expression of both mevalonate kinase and cob(I)alamin adenosyltransferase
Manually annotated by BRENDA team
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a clonal osteoblast-like mouse calvarial cell line
Manually annotated by BRENDA team
additional information
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mevalonate kinase and cob(I)alamin adenosyltransferase display a similar tissue expression pattern. Their genes are located in a head-to-head formation and are suppressed by an excess of cholesterol as well as sterol regulatory element binding protein SREBP-2
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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the enzyme is part of the mevalonate pathway leading to the production of farnesyl diphosphate and geranylgeranyl diphosphate, overview
additional information
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mevalonate kinase and Rho kinase are involved in regulation of BMP-2 mRNA expression, inhibition of both enzymes in osteoblastic MC3T3-E1 cells upregulates BMP-2 mRNA expression
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KIME_MOUSE
395
0
41877
Swiss-Prot
other Location (Reliability: 3)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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deletion of one mevalonate kinase allele yields viable mice with significantly reduced liver mevalonate kinase enzyme activity. Cholesterol levels in tissues and blood, and isoprene end-products ubiquinone and dolichol in tissues are normal in Mvk+/- mice. Mevalonate concentrations are increased in spleen, heart, and kidney yet normal in brain and liver. While the trend is for higher IgA levels in Mvk+/- sera, IgD levels are significantly increased and the animals show increased serum tumor necrosis factor-alpha levels
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
parathyroid hormone, from human source comprising residues 1-34, suppresses the mevalonate kinase in osteoblastic cells
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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mouse model for typical mevalonate kinase deficiency can be obtained by treatment of BALB/c mice with aminobisphosphonate alendronate and bacterial muramyldipeptide. Exogenous isoprenoids geraniol, farnesol and geranylgeraniol are effective in prevention of the inflammation induced by alendronate/muramyldipeptide
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Murphy, C.; Murray, A.M.; Meaney, S.; Gafvels, M.
Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism
Biochem. Biophys. Res. Commun.
355
359-364
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Schirra, F.; Richards, S.M.; Sullivan, D.A.
Androgen influence on cholesterogenic enzyme mRNA levels in the mouse meibomian gland
Curr. Eye Res.
32
393-398
2007
Mus musculus (Q9R008), Mus musculus
Manually annotated by BRENDA team
Hager, E.J.; Tse, H.M.; Piganelli, J.D.; Gupta, M.; Baetscher, M.; Tse, T.E.; Pappu, A.S.; Steiner, R.D.; Hoffmann, G.F.; Gibson, K.M.
Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome
J. Inherit. Metab. Dis.
30
888-895
2007
Mus musculus
Manually annotated by BRENDA team
Marcuzzi, A.; Pontillo, A.; De Leo, L.; Tommasini, A.; Decorti, G.; Not, T.; Ventura, A.
Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency
Pediatr. Res.
64
177-182
2008
Mus musculus
Manually annotated by BRENDA team
Takase, H.; Yano, S.; Yamaguchi, T.; Kanazawa, I.; Hayashi, K.; Yamamoto, M.; Yamauchi, M.; Sugimoto, T.
Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells
Horm. Metab. Res.
41
861-865
2009
Mus musculus
Manually annotated by BRENDA team