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The taxonomic range for the selected organisms is: Thermococcus kodakarensis
The enzyme appears in selected viruses and cellular organisms
Synonyms
pank2, pantothenate kinase, pantothenate kinase 2, pank1, pank3, pank4, pank-iii, pantothenate kinase-2, type ii pantothenate kinase, pfpank1,
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4-phosphopantoate
non-competitive
D-pantothenate kinase
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kinase, pantothenate (phosphorylating)
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pantothenic acid kinase
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phospho group transfer
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ATP:(R)-pantothenate 4'-phosphotransferase
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ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
the enzyme is involved in coenzyme A biosynthesis in the archaea
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ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
the enzyme is involved in coenzyme A biosynthesis in the archaea
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4-phosphopantoate
substrate inhibition
additional information
feedback inhibition by CoA/acetyl-CoA and product inhibition by 4'-phosphopantothenate are not observed
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additional information
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feedback inhibition by CoA/acetyl-CoA and product inhibition by 4'-phosphopantothenate are not observed
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UniProt
brenda
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the TK2141 gene encoding PoK, with a His6-Tag on its N-terminus, is overexpressed in Thermococcus kodakarensis
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Ishibashi, T.; Tomita, H.; Yokooji, Y.; Morikita, T.; Watanabe, B.; Hiratake, J.; Kishimoto, A.; Kita, A.; Miki, K.; Imanaka, T.; Atomi, H.
A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea
Extremophiles
16
819-828
2012
Thermococcus kodakarensis (Q5JHF1), Thermococcus kodakarensis
brenda
2.7.1.33 pantothenate kinase
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