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EC Tree
The taxonomic range for the selected organisms is: Methanocaldococcus jannaschii
The enzyme appears in selected viruses and cellular organisms
Synonyms
nad kinase, nadk, nad+ kinase, nadk2, nad(h) kinase, utr1p, osnadk1,
slr0400, c5orf33,
sll1415,
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ATP:NAD 2'-phosphotransferase
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kinase (phosphorylating), nicotinamide adenine dinucleotide
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kinase, nicotinamide adenine dinucleotide (phosphorylating)
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NADP phosphatase/NAD kinase
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nicotinamide adenine dinucleotide kinase
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Poly(P)/ATP NAD kinase
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polyphosphate/ATP-NAD kinase
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phospho group transfer
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ATP:NAD+ 2'-phosphotransferase
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ATP + NADH
ADP + NADPH
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?
fructose-1,6-bisphosphate + ?
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?
NADH + poly(P)4
NADPH + poly(P)3
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?
ATP + NAD+
ADP + NADP+
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?
ATP + NADH
ADP + NADPH
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14% of the activity NAD+
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?
CTP + NAD+
CDP + NADP+
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102% of the activity with ATP
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dATP + NAD+
dADP + NADP+
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73% of the activity with ATP
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GTP + NAD+
GDP + NADP+
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66% of the activity with ATP
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hexametaphosphate + NAD+
NADP+ + ?
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47% of the activity with ATP
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?
TTP + NAD+
TDP + NADP+
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71% of the activity with ATP
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UTP + NAD+
UDP + NADP+
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114% of the activity with ATP
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additional information
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the enzyme also shows phosphatase activity
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ATP + NAD+
ADP + NADP+
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ATP + NAD+
ADP + NADP+
the enzyme regulates the intracellular balance of NAD(H) and NADP(H)
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?
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ATP + NAD+
ADP + NADP+
the enzyme regulates the intracellular balance of NAD(H) and NADP(H)
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?
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Mg2+
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activity is dependent on Mg2+, maximal activity at 50 mM
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ADP
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3 mM, 29% inhibition
NADP+
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0.3 mM, complete inhibition
NADPH
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0.3 mM, 18% inhibition
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5'-AMP
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1.56fold activation at 3.0 mM
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0.43
fructose-1,6-bisphosphate
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0.35
ATP
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85°C, pH 8.5, 20 mM Mg2+
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NAD+
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85°C, pH 8.5, 20 mM Mg2+
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212
fructose-1,6-bisphosphate
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399
ATP
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85°C, pH 8.5, 20 mM Mg2+
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NAD+
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85°C, pH 8.5, 20 mM Mg2+
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6.5 - 9.5
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pH 6.5: about 35% of maximal activity, pH 9.5: about 90% of maximal activity
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80 - 100
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80°C: about 45% of maximal activity, 100°C: optimum
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UniProt
brenda
cf. EC 3.1.3.108
UniProt
brenda
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physiological function
the enzyme regulates the intracellular balance of NAD(H) and NADP(H)
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expression in Escherichia coli
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additional information
one of the key enzymes regulating the balance of NAD(H) and NADP(H)
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Kawai, S.; Fukuda, C.; Mukai, T.; Murata, K.
MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase
J. Biol. Chem.
280
39200-39207
2005
Methanocaldococcus jannaschii
brenda
Kawai, S.; Murata, K.
Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H)
Biosci. Biotechnol. Biochem.
72
919-930
2008
Arabidopsis thaliana, Arabidopsis thaliana (Q500Y9), Arabidopsis thaliana (Q56YN3), Arabidopsis thaliana (Q9C5W3), Archaeoglobus fulgidus, Bacillus subtilis (O31612), Bacillus subtilis (O34934), Candida albicans, Columba livia, Cyberlindnera jadinii, Dictyostelium discoideum, Escherichia coli (P0A7B3), Glycine max, Homo sapiens, Homo sapiens (O95544), Lactuca sativa, Listeria monocytogenes, Methanocaldococcus jannaschii (Q58327), Micrococcus luteus (Q8VUL9), Mycobacterium tuberculosis (P9WHV7), Mycobacterium tuberculosis H37Rv (P9WHV7), Oryza sativa, Pyrococcus horikoshii (O58801), Saccharomyces cerevisiae (C7GKE4), Saccharomyces cerevisiae (P21373), Saccharomyces cerevisiae (P32622), Saccharomyces cerevisiae (Q06892), Saccharomyces cerevisiae, Salmonella enterica, Schizosaccharomyces pombe, Sorghum sp., Sphingomonas sp. A1 (Q6L7J5), Synechococcus elongatus PCC 6301, Thermotoga maritima, Triticum sp.
brenda
Kawai, S.; Murata, K.
Structure and function of NAD kinase and NADP phosphatase key enzymes that regulate the intracellular balance of NAD(H) and NADP(H)
Biosci. Biotechnol. Biochem.
72
919-930
2008
Methanocaldococcus jannaschii (Q58327), Methanocaldococcus jannaschii ATCC 43067 (Q58327)
brenda
2.7.1.23 NAD+ kinase
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