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Information on EC 2.7.1.228 - mannosyl-inositol-phosphoceramide inositolphosphotransferase

for references in articles please use BRENDA:EC2.7.1.228

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IUBMB Comments

This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-α-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C).

The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae
Reaction Schemes
+
a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide
=
+
a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide

Synonyms
IPT1, YDR072c, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-phosphatidyl-1D-myo-inositol + a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
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