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IUBMB CommentsThe enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
D-threonate kinase,
dtnK,
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D-threonate kinase

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dtnK

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ATP + D-threonate = ADP + 4-phospho-D-threonate
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ATP:D-threonate 4-phosphotransferase
The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.
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ATP + 4-hydroxy-L-threonine
ADP + 4-phospho-L-threonine
ATP + D-threonate
ADP + 4-phospho-D-threonate
ATP + 4-hydroxy-L-threonine

ADP + 4-phospho-L-threonine
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-
?
ATP + 4-hydroxy-L-threonine
ADP + 4-phospho-L-threonine
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-
-
?
ATP + 4-hydroxy-L-threonine
ADP + 4-phospho-L-threonine
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?
ATP + 4-hydroxy-L-threonine
ADP + 4-phospho-L-threonine
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-
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?
ATP + D-threonate

ADP + 4-phospho-D-threonate
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?
ATP + D-threonate
ADP + 4-phospho-D-threonate
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ATP + D-threonate
ADP + 4-phospho-D-threonate
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?
ATP + D-threonate
ADP + 4-phospho-D-threonate
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?
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3.8 - 86
4-hydroxy-L-threonine
3.8
4-hydroxy-L-threonine

pH 8.0, 25°C
86
4-hydroxy-L-threonine
pH 8.0, 25°C
0.12
D-threonate

pH 8.0, 25°C
0.29
D-threonate
pH 8.0, 25°C
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4 - 27
4-hydroxy-L-threonine
4
4-hydroxy-L-threonine

pH 8.0, 25°C
27
4-hydroxy-L-threonine
pH 8.0, 25°C
22
D-threonate

pH 8.0, 25°C
45
D-threonate
pH 8.0, 25°C
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0.31 - 1.1
4-hydroxy-L-threonine
0.31
4-hydroxy-L-threonine

pH 8.0, 25°C
1.1
4-hydroxy-L-threonine
pH 8.0, 25°C
75
D-threonate

pH 8.0, 25°C
380
D-threonate
pH 8.0, 25°C
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member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
UniProt
brenda
member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
UniProt
brenda
member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
UniProt
brenda
member of the DUF1537 family, participates in catabolic pathways for four-carbon acid sugars
UniProt
brenda
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physiological function

a gene deletion strain is unable to use D-threonate as a carbon source
physiological function
a gene deletion strain is unable to use D-threonate as a carbon source
physiological function
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a gene deletion strain is unable to use D-threonate as a carbon source
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physiological function
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a gene deletion strain is unable to use D-threonate as a carbon source
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DTNK_BORBR
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
405
0
40922
Swiss-Prot
-
DTNK_CUPNH
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
415
0
42589
Swiss-Prot
-
DTNK_PECAS
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
442
0
46672
Swiss-Prot
-
DTNK_SALTY
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
423
0
44986
Swiss-Prot
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A0A653LNZ2_9BURK
440
0
44871
TrEMBL
-
A0A6I5ZTA3_9THEO
439
0
45988
TrEMBL
-
A0A5E6ZID9_PSEFL
426
0
45248
TrEMBL
-
A0A644VML2_9ZZZZ
419
0
43060
TrEMBL
other Location (Reliability: 1)
A0A6N8I4F0_9FIRM
408
0
43561
TrEMBL
-
A0A6S6YVY6_9BURK
405
0
41033
TrEMBL
-
A0A645I9X8_9ZZZZ
178
0
18764
TrEMBL
other Location (Reliability: 4)
A0A6S7AJE7_9BURK
405
0
41048
TrEMBL
-
A0A6S7C2Y3_9BURK
406
0
40826
TrEMBL
-
A0A811GRQ1_9BURK
405
0
41270
TrEMBL
-
A0A6J5GC22_9BURK
446
0
46316
TrEMBL
-
A0A654DFG0_9PSED
416
0
43958
TrEMBL
-
A0A6S7DRV3_9BURK
73
0
7306
TrEMBL
-
A0A6S7D2Y0_9BURK
384
0
39332
TrEMBL
-
A0A833QD42_BURGA
433
0
44436
TrEMBL
-
A0A6S7EEV9_9BURK
406
0
40886
TrEMBL
-
A0A6J5AHA3_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
448
0
46423
TrEMBL
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A0A653ZLS9_9MICC
356
0
36631
TrEMBL
-
A0A7S4H5Q4_9GAMM
422
0
44523
TrEMBL
-
A0A543Q764_ACITH
446
0
48665
TrEMBL
-
A0A6S7EJF4_9BURK
389
0
39629
TrEMBL
-
A0A644XSU1_9ZZZZ
392
0
42496
TrEMBL
other Location (Reliability: 4)
A0A5C0WHB5_BACIA
447
0
49358
TrEMBL
-
A0A654D4G6_9GAMM
423
0
44780
TrEMBL
-
A0A645E4J2_9ZZZZ
290
0
31447
TrEMBL
other Location (Reliability: 3)
A0A6J5F6R8_9BURK
455
0
46991
TrEMBL
-
A0A6J5B6V1_9BURK
109
0
10734
TrEMBL
-
A0A653LL16_9GAMM
440
0
46563
TrEMBL
-
A0A5E7I9Q9_PSEFL
426
0
45374
TrEMBL
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A0A5E7ETI0_PSEFL
426
0
45287
TrEMBL
-
D4GUQ9_HALVD
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
412
0
42544
TrEMBL
-
A0A6S7B7B7_9BURK
109
0
10783
TrEMBL
-
A0A6J5E7M8_9BURK
453
0
46861
TrEMBL
-
A0A6S7E5H0_9BURK
406
0
40892
TrEMBL
-
A0A6S7ALD5_9BURK
405
0
41135
TrEMBL
-
A0A6S7BMT3_9BURK
448
0
46292
TrEMBL
-
A0A6S7B6Z9_9BURK
444
0
46184
TrEMBL
-
A0A653SX92_9ACTN
406
0
41865
TrEMBL
-
A0A5D3HZA7_MOOTH
430
0
45894
TrEMBL
-
A0A6S7F8C1_9BURK
405
0
41047
TrEMBL
-
A0A6S7DIU4_9BURK
405
0
41097
TrEMBL
-
A0A645BQA8_9ZZZZ
175
0
18751
TrEMBL
other Location (Reliability: 2)
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Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
Assignment of function to a domain of unknown function DUF1537 is a new kinase family in catabolic pathways for acid sugars
Proc. Natl. Acad. Sci. USA
113
E4161-E4169
2016
Cupriavidus necator (Q0K4F6), Salmonella enterica subsp. enterica serovar Typhimurium (Q8ZRS5), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (Q8ZRS5), Cupriavidus necator DSM 428 (Q0K4F6)
brenda
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