Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acquired Immunodeficiency Syndrome
3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells.
Acquired Immunodeficiency Syndrome
Acyclovir-resistant bilateral keratitis associated with mutations in the HSV-1 thymidine kinase gene.
Acquired Immunodeficiency Syndrome
Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS.
Acquired Immunodeficiency Syndrome
Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed.
Acquired Immunodeficiency Syndrome
Meningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient.
Acquired Immunodeficiency Syndrome
Serum thymidine kinase (TK) evaluation in HIV infection.
Acquired Immunodeficiency Syndrome
Serum thymidine kinase in AIDS patients treated with zidovudine.
Acquired Immunodeficiency Syndrome
Serum thymidine kinase--a marker of bone marrow toxicity during treatment with zidovudine.
Acquired Immunodeficiency Syndrome
Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
Acute Kidney Injury
Apoptosis of the thick ascending limb results in acute kidney injury.
Adenocarcinoma
3'-untranslated region of SP-B mRNA mediates inhibitory effects of TPA and TNF-alpha on SP-B expression.
Adenocarcinoma
Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer.
Adenocarcinoma
Correlation between histological differentiation and DNA-synthesizing enzymes in rat colorectal tumors induced with 1, 2-dimethylhydrazine.
Adenocarcinoma
Gene dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas.
Adenocarcinoma
Human colon tumors: enzymic and histological characteristics.
Adenocarcinoma
Human epithelial ovarian cancer xenotransplants into nude mice can be cured by adenovirus-mediated thymidine kinase gene therapy.
Adenocarcinoma
In vitro model of suicide gene therapy for alpha-fetoprotein-producing gastric cancer.
Adenocarcinoma
Increased activities of thymidine kinase isozymes in human mammary tumours.
Adenocarcinoma
Killing effects of ganciclovir on human pulmonary adenocarcinoma cell A549 transduced with HSV1-TK gene in vitro and in vivo.
Adenocarcinoma
Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.
Adenocarcinoma
Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer.
Adenocarcinoma
Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases.
Adenocarcinoma
Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer.
Adenocarcinoma
Serum thymidine kinase is associated with gastric adenocarcinoma.
Adenocarcinoma
Similar efficiency of DNA-liposome complexes and retrovirus-producing cells for HSV-tk suicide gene therapy of peritoneal carcinomatosis.
Adenocarcinoma
Suicide gene therapy for human uterine adenocarcinoma cells using herpes simplex virus thymidine kinase.
Adenocarcinoma
Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues.
Adenocarcinoma
Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker.
Adenocarcinoma
Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung.
Adenocarcinoma
[Growing characteristic of breast adenocarcinoma suicide gene cell line T47D-tk and construction of subcutaneous xenografts]
Adenocarcinoma of Lung
Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma.
Adenocarcinoma of Lung
Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles.
Adenocarcinoma of Lung
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
Adenocarcinoma of Lung
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.
Adenocarcinoma of Lung
Selective gene therapy for human lung adenocarcinoma by tumor-specific expression of herpes simplex virus thymidine kinase gene.
Adenocarcinoma of Lung
Smoke Chemistry, In Vitro Cytotoxicity, and Genotoxicity Demonstrates Enhanced Toxicity of Cigarillos Compared With Cigarettes.
Adenocarcinoma of Lung
Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung.
Adenocarcinoma, Bronchiolo-Alveolar
Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells.
Adenoma
GENE THERAPY FOR THE TREATMENT OF PITUITARY TUMORS.
Adenoma
Increased thymidine kinase activity in human thyroid toxic adenomas: effects of exposure to epidermal growth factor in vitro.
Adenoma
Isolation of human-mouse somatic cell hybrids producing human prolactin: dominant expression of hormone secretion and regulation.
Adenoma
Properties of partially purified thymidine kinase in adrenal tissue of hyperplasia, adenomatous hyperplasia, adenoma and carcinoma of patients with Cushing's syndrome.
Adenoma
Serum thymidine kinase in colorectal neoplasia.
Adenoma, Pleomorphic
[The effects of HSV-tk suicide gene and wild-type p53 gene on pleomorphic adenoma cells of salivary gland]
Adenomatous Polyposis Coli
Effects of carcinogenesis on colonic thymidine kinase activity in familial adenomatous polyposis.
Adenomatous Polyposis Coli
Thymidine kinase activity in familial adenomatous polyposis.
Adenoviridae Infections
A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.
Adenoviridae Infections
Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial.
Adrenocortical Carcinoma
Properties of thymidine kinase partially purified from human adrenal glands.
African Swine Fever
African swine fever virus thymidylate kinase gene: sequence and transcriptional mapping.
African Swine Fever
Altered thymidine kinase activity in culture cells inoculated with African swine fever virus.
African Swine Fever
Deletion of the thymidine kinase gene induces complete attenuation of the Georgia isolate of African swine fever virus.
African Swine Fever
Evidence for the evolution of ascoviruses from iridoviruses.
African Swine Fever
Expression and characterization of the thymidine kinase gene of African swine fever virus.
African Swine Fever
Isolation and characterization of TK-deficient mutants of African swine fever virus.
African Swine Fever
Sequence and evolutionary relationships of African swine fever virus thymidine kinase.
African Swine Fever
The African swine fever virus thymidine kinase gene is required for efficient replication in swine macrophages and for virulence in swine.
AIDS-Related Complex
Serum thymidine kinase--a marker of bone marrow toxicity during treatment with zidovudine.
Alzheimer Disease
Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type.
Alzheimer Disease
Neurotropic viruses and Alzheimer's disease: a search for varicella zoster virus DNA by the polymerase chain reaction.
Anemia
Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice.
Anemia
Serum thymidine kinase in congenital dyserythropoietic anaemia type I and homozygous beta-thalassaemia.
Anemia
Serum thymidine kinase in congenital dyserythropoietic anaemia type III.
Anemia
Thymidine kinase in megaloblastic anaemia.
Anemia
[Mantle cell lymphoma as a diagnostic and therapeutic problem]
Anemia, Dyserythropoietic, Congenital
Serum thymidine kinase in congenital dyserythropoietic anaemia type I and homozygous beta-thalassaemia.
Anemia, Dyserythropoietic, Congenital
Serum thymidine kinase in congenital dyserythropoietic anaemia type III.
Anemia, Hemolytic
Serum Thymidine Kinase 1, Canine-C-Reactive Protein, Haptoglobin, and Vitamin D Concentrations in Dogs with Immune-Mediated Hemolytic Anemia, Thrombocytopenia, and Polyarthropathy.
Anemia, Megaloblastic
Plasma thymidine kinase in megaloblastic anaemia.
Anemia, Megaloblastic
Serum thymidine kinase in megaloblastic anaemia.
Anemia, Megaloblastic
Thymidine kinase in megaloblastic anaemia.
Arthritis
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Arthritis
Molecular lysis of synovial lining cells by in vivo herpes simplex virus-thymidine kinase gene transfer.
Arthritis, Rheumatoid
Clinical trials in the gene therapy of arthritis.
Astrocytoma
Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Astrocytoma
[Preclinical studies on thymidine kinase gene (TK) and gancyclovir system for treatment of malignant astrocytoma]
Bacterial Infections
Biodistribution, PET, and radiation dosimetry estimates of HSV-tk gene expression imaging agent 1-(2'-Deoxy-2'-18F-Fluoro-beta-D-arabinofuranosyl)-5-iodouracil in normal dogs.
Bacterial Infections
Elevation of serum thymidine kinase 1 in a bacterial infection: canine pyometra.
Bacterial Infections
Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.
Bacterial Infections
Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides.
Bacterial Infections
The use of (14)C-FIAU to predict bacterial thymidine kinase presence: Implications for radiolabeled FIAU bacterial imaging.
Blast Crisis
[Thymidine kinase activity in leukocytes from patients with chronic myeloid leukemia at various periods in the disease]
Bloom Syndrome
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Bluetongue
Bluetongue Virus Particles as Nanoreactors for Enzyme Delivery and Cancer Therapy.
Bone Diseases
Bone marrow biopsy in monoclonal gammopathies: correlations between pathological findings and clinical data. The Cooperative Group for Study and Treatment of Multiple Myeloma.
Brain Diseases
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
Brain Injuries
Imaging grafted cells with [18F]FHBG using an optimized HSV1-TK mammalian expression vector in a brain injury rodent model.
Brain Injuries
Neuroprotective effects of resident microglia following acute brain injury.
Brain Neoplasms
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
Brain Neoplasms
Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.
Brain Neoplasms
An improved retroviral vector encoding the herpes simplex virus thymidine kinase gene increases antitumor efficacy in vivo.
Brain Neoplasms
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Brain Neoplasms
Applications of positron emission tomography in neuro-oncology: A clinical approach.
Brain Neoplasms
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.
Brain Neoplasms
Connexins are expressed in primary brain tumors and enhance the bystander effect in gene therapy.
Brain Neoplasms
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Brain Neoplasms
Developing Implantable Scaffolds to Enhance Neural Stem Cell Therapy for Post-Operative Glioblastoma.
Brain Neoplasms
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.
Brain Neoplasms
Efficacy of suicide gene therapy in hypoxic rat 9L glioma cells.
Brain Neoplasms
Eradication of murine brain tumors by direct inoculation of concentrated high titer-recombinant retrovirus harboring the herpes simplex virus thymidine kinase gene.
Brain Neoplasms
Ganciclovir mediated regression of rat brain tumors expressing the herpes simplex virus thymidine kinase imaged by magnetic resonance.
Brain Neoplasms
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir.
Brain Neoplasms
Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Brain Neoplasms
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Brain Neoplasms
Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors.
Brain Neoplasms
Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy.
Brain Neoplasms
Imaging the expression of transfected genes in vivo.
Brain Neoplasms
In vitro study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant brain tumors.
Brain Neoplasms
In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors.
Brain Neoplasms
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Brain Neoplasms
Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study.
Brain Neoplasms
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy.
Brain Neoplasms
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.
Brain Neoplasms
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Brain Neoplasms
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Brain Neoplasms
Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors.
Brain Neoplasms
Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients.
Brain Neoplasms
New drug delivery system for water-soluble drugs using silicone and its usefulness for local treatment: application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor.
Brain Neoplasms
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.
Brain Neoplasms
PET reporter gene imaging and ganciclovir-mediated ablation of chimeric antigen receptor T-cells in solid tumors.
Brain Neoplasms
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Brain Neoplasms
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Brain Neoplasms
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Brain Neoplasms
Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas.
Brain Neoplasms
Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors.
Brain Neoplasms
Strategies for gene therapy.
Brain Neoplasms
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
Brain Neoplasms
Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors.
Brain Neoplasms
Thymidine kinase in extracts of human brain tumours.
Brain Neoplasms
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.
Brain Neoplasms
Treatment of rat experimental brain tumors by herpes simplex virus thymidine kinase gene-transduced allogeneic tumor cells and ganciclovir.
Brain Neoplasms
Viruses in the treatment of brain tumors.
Breast Neoplasms
207 engineered human amniotic fluid-derived stem cells by expressing Cytosine deaminase (cd) and thymidine kinase (hsv-tk) mediate targeting killing effect in breast cancer cells.
Breast Neoplasms
A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer.
Breast Neoplasms
A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells.
Breast Neoplasms
A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir.
Breast Neoplasms
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
Breast Neoplasms
Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer.
Breast Neoplasms
Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.
Breast Neoplasms
Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Breast Neoplasms
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Breast Neoplasms
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Breast Neoplasms
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Breast Neoplasms
Breast tumour thymidine kinase levels and disease recurrence.
Breast Neoplasms
Can thymidine kinase levels in breast tumors predict disease recurrence?
Breast Neoplasms
Clinical value of thymidine kinase and tissue polypeptide specific antigen in breast cancer.
Breast Neoplasms
Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas.
Breast Neoplasms
Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects.
Breast Neoplasms
Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas.
Breast Neoplasms
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Breast Neoplasms
Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients.
Breast Neoplasms
Coordination of transcription of the human 17 beta-hydroxysteroid dehydrogenase type 1 gene (EDH17B2) by a cell-specific enhancer and a silencer: identification of a retinoic acid response element.
Breast Neoplasms
Cytosolic thymidine kinase is a specific histopathologic tumour marker for breast carcinomas.
Breast Neoplasms
Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer.
Breast Neoplasms
Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model.
Breast Neoplasms
Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging.
Breast Neoplasms
Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume.
Breast Neoplasms
Effect of hypoxia on human equilibrative nucleoside transporters hENT1 and hENT2 in breast cancer.
Breast Neoplasms
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Breast Neoplasms
Elevated levels of thymidine kinase 1 peptide in serum from patients with breast cancer.
Breast Neoplasms
Elevated thymidine kinase 1 in serum following neoadjuvant chemotherapy predicts poor outcome for patients with locally advanced breast cancer.
Breast Neoplasms
Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir.
Breast Neoplasms
EORTC receptor and biomarker study group report analytical and technical evaluation of a thymidine kinase radio-enzymatic assay in breast cancer cytosols.
Breast Neoplasms
Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter.
Breast Neoplasms
Evaluating Serum Thymidine Kinase 1 in Hormone Receptor Positive Metastatic Breast Cancer Patients Receiving First Line Endocrine Therapy in the SWOG S0226 Trial.
Breast Neoplasms
Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer.
Breast Neoplasms
FISH localization of the soluble thymidine kinase gene (TK1) to human 17q25, a region of chromosomal loss in sporadic breast tumors.
Breast Neoplasms
Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase.
Breast Neoplasms
HRPAP20: a novel calmodulin-binding protein that increases breast cancer cell invasion.
Breast Neoplasms
Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models.
Breast Neoplasms
Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene.
Breast Neoplasms
In vivo efficacy of folate-targeted lipid-protamine-DNA (LPD-PEG-Folate) complexes in an immunocompetent syngeneic model for breast adenocarcinoma.
Breast Neoplasms
Inducible expression of herpes simplex virus thymidine kinase increases sensitivity to ganciclovir but does not enhance bystander effect in breast cancer cells.
Breast Neoplasms
Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs.
Breast Neoplasms
Inhibition of thymidine kinase in cultured mammary tumor cells by the chemopreventive organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.
Breast Neoplasms
Local regression of breast tumors following intramammary ganciclovir administration in double transgenic mice expressing neu oncogene and herpes simplex virus thymidine kinase.
Breast Neoplasms
Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter.
Breast Neoplasms
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.
Breast Neoplasms
Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence.
Breast Neoplasms
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Breast Neoplasms
Plasma thymidine kinase 1 activity and outcome of ER+ HER2- metastatic breast cancer patients treated with palbociclib and endocrine therapy.
Breast Neoplasms
Plasma thymidine kinase activity as a biomarker in patients with luminal metastatic breast cancer treated with palbociclib within the TREnd trial.
Breast Neoplasms
Plasma thymidine kinase-1 activity predicts outcome in patients with hormone receptor positive and HER2 negative metastatic breast cancer treated with endocrine therapy.
Breast Neoplasms
Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Breast Neoplasms
Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors.
Breast Neoplasms
Preliminary in vitro efficacy and toxicities studies of the herpes simplex thymidine kinase gene system for the treatment of breast cancer.
Breast Neoplasms
Progestin stimulation of thymidine kinase in the human breast cancer cell line T47D.
Breast Neoplasms
Prognostic importance of thymidine kinase in colorectal and breast cancer.
Breast Neoplasms
Prognostic role of serum thymidine kinase 1 activity in patients with hormone receptor-positive metastatic breast cancer: Analysis of the randomised phase III Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT).
Breast Neoplasms
Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer.
Breast Neoplasms
Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer.
Breast Neoplasms
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker.
Breast Neoplasms
Purification and properties of estrogen-responsive cytoplasmic thymidine kinase from human breast cancer.
Breast Neoplasms
Relationship between thymidine kinase 1 before radiotherapy and prognosis in breast cancer patients with diabetes.
Breast Neoplasms
Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands.
Breast Neoplasms
Serial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer.
Breast Neoplasms
Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib.
Breast Neoplasms
Serum thymidine kinase 1 activity in breast cancer.
Breast Neoplasms
Serum thymidine kinase 1 levels predict cancer-free survival following neoadjuvant, surgical and adjuvant treatment of patients with locally advanced breast cancer.
Breast Neoplasms
Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial.
Breast Neoplasms
Serum tumour markers as a diagnostic and prognostic tool in Libyan breast cancer.
Breast Neoplasms
STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.
Breast Neoplasms
Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation.
Breast Neoplasms
Technical evaluation of thymidine kinase assay in cytosols from breast cancers. EORTC Receptor Study Group Report.
Breast Neoplasms
The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody.
Breast Neoplasms
Thymidine kinase 1 immunoassay: a potential marker for breast cancer.
Breast Neoplasms
Thymidine kinase 1 in serum predicts increased risk of distant or loco-regional recurrence following surgery in patients with early breast cancer.
Breast Neoplasms
Thymidine kinase 1 upregulation is an early event in breast tumor formation.
Breast Neoplasms
Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
Breast Neoplasms
Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy.
Breast Neoplasms
Thymidine kinase as a predictor of response to chemotherapy in advanced breast cancer.
Breast Neoplasms
Thymidine kinase as a proliferative marker: clinical relevance in 1,692 primary breast cancer patients.
Breast Neoplasms
Thymidine kinase in breast cancer.
Breast Neoplasms
Thymidine kinase-1 as a biomarker in breast cancer: estimating prognosis and early recognition of treatment resistance.
Breast Neoplasms
Thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell apoptosis in breast cancer cells.
Breast Neoplasms
Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells.
Breast Neoplasms
Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences.
Breast Neoplasms
[Activity of the enzymes of DNA metabolism in the blood of patients with breast cancer]
Breast Neoplasms
[Close relation between fetal thymidine kinase and thymidylate kinase activities in breast cancer]
Breast Neoplasms
[Demonstration of fetal-type thymidine kinase in cancer of the breast]
Breast Neoplasms
[Growing characteristic of breast adenocarcinoma suicide gene cell line T47D-tk and construction of subcutaneous xenografts]
Breast Neoplasms
[Prognostic value of fetal thymidine kinase measurements in breast cancer]
Breast Neoplasms
[Prognostic value of thymidine kinase in cancer of the breast]
Breast Neoplasms
[Standardization and quality control in the evaluation of proliferation parameters in T1T2, N0N1, M0 breast cancer: multicentric retrospective study II. DNA-ploidy and S-phase fraction]
Breast Neoplasms
[Thymidine kinase activity and its isoenzymes in breast tumors]
Breast Neoplasms
[Use of enzyme test in chemotherapy of patients with cancer of the breast]
Breast Neoplasms
[Value of thymidine kinase in the prediction of response to treatment by chemotherapy or hormone therapy in breast cancer]
Bronchitis
Study of protection by recombinant fowl poxvirus expressing C-terminal nucleocapsid protein of infectious bronchitis virus against challenge.
Burkitt Lymphoma
Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked.
Burkitt Lymphoma
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.
Burkitt Lymphoma
Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues.
Carcinogenesis
Alterations in colonic thymidine kinase enzyme activity induced by consumption of various dietary fibers.
Carcinogenesis
Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis.
Carcinogenesis
Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
Carcinogenesis
Effects of carcinogenesis on colonic thymidine kinase activity in familial adenomatous polyposis.
Carcinogenesis
Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Carcinogenesis
Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice.
Carcinogenesis
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Carcinogenesis
Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model.
Carcinoid Tumor
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma
A simple and efficient liposome method for transfection of DNA into mammalian cells grown in suspension.
Carcinoma
Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system.
Carcinoma
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Carcinoma
Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir.
Carcinoma
Adenovirus-mediated suicide gene therapy for experimental bladder cancer.
Carcinoma
Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Carcinoma
Antigenic immunostaining patterns in somatic hybrids of human HeLa cells and mouse fibroblasts 3T3.4E propagated in conventional medium and delipidized serum.
Carcinoma
Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth.
Carcinoma
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Carcinoma
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.
Carcinoma
Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
Carcinoma
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Carcinoma
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Carcinoma
Clinical Significance and Role of TK1, CEA, CA 19-9 and CA 72-4 levels in Diagnosis of Colorectal Cancers.
Carcinoma
Clinical value of thymidine kinase in patients with cervical carcinoma.
Carcinoma
Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas.
Carcinoma
Combination electro-gene therapy using herpes virus thymidine kinase and interleukin-12 expression plasmids is highly efficient against murine carcinomas in vivo.
Carcinoma
Combined suicide and cytokine gene therapy for peritoneal carcinomatosis.
Carcinoma
Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity.
Carcinoma
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Carcinoma
Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.
Carcinoma
Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model.
Carcinoma
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Carcinoma
Differences in thermostability of thymidine kinase isoenzymes in normal ovary and ovarian carcinoma.
Carcinoma
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase.
Carcinoma
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Carcinoma
Effects of kampo (Japanese herbal) medicine "sho-saiko-to" on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced colonic carcinomas in rats.
Carcinoma
Enzyme pathology of human mesotheliomas.
Carcinoma
Establishment and characterization of cell lines from the Walker carcinoma 256 able to grow in suspension culture and deficient in thymidine kinase.
Carcinoma
Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene.
Carcinoma
Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene.
Carcinoma
Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study.
Carcinoma
Experimental gene therapy in mammary and urinary bladder cancer using electrogene transfer.
Carcinoma
Exposed proliferation antigen 210 (XPA-210) in renal cell carcinoma (RCC) and oncocytoma: clinical utility and biological implications.
Carcinoma
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
Carcinoma
Expression of thymidine kinase driven by an endothelial-specific promoter inhibits tumor growth of Lewis lung carcinoma cells in transgenic mice.
Carcinoma
Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk.
Carcinoma
Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase.
Carcinoma
Gastrointestinal tumor markers, other than carcinoembryonic antigen, and alpha fetal protein.
Carcinoma
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
Carcinoma
Herpesvirus type 2-induced thymidine kinase and carcinoma of the cervix.
Carcinoma
High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.
Carcinoma
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Carcinoma
Hormonal effects on thymidine kinase activity in normal rat adrenal and in hormone-dependent adrenal carcinoma.
Carcinoma
HSV-tk gene therapy for human renal cell carcinoma in nude mice.
Carcinoma
HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect.
Carcinoma
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.
Carcinoma
Identification and characterization of the human retinoid X receptor alpha gene promoter.
Carcinoma
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.
Carcinoma
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
Carcinoma
In vivo transfer of a foreign gene to keratinocytes using the hemagglutinating virus of Japan-liposome method.
Carcinoma
Increased activities of thymidine kinase isozymes in human colon polyp and carcinoma.
Carcinoma
Increased activity of thymidine kinase isozyme in human colon tumor.
Carcinoma
Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma.
Carcinoma
Inhibition of thymidine kinase from Walker 256 carcinoma by thymidine analogs.
Carcinoma
Irreversible enzyme inhibitors. 195. Inhibitors of thymidine kinase from Walker 256 carcinoma derived from thymidine 5'-acetate.
Carcinoma
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
Carcinoma
Methotrexate decreases thymidine kinase activity.
Carcinoma
Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy.
Carcinoma
Mitochondrial nucleic acids as internal standards for blot hybridization analyses.
Carcinoma
Modulation of IdUrd-DNA incorporation and radiosensitization in human bladder carcinoma cells.
Carcinoma
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.
Carcinoma
Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells.
Carcinoma
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Carcinoma
Noninvasive assessment of cell proliferation in ovarian cancer using [18F] 3'deoxy-3-fluorothymidine positron emission tomography/computed tomography imaging.
Carcinoma
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Carcinoma
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Carcinoma
Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene.
Carcinoma
Pathological features and pyrimidine nucleotide synthesis in human gastric carcinomas.
Carcinoma
Plasmid DNA mediated transfer of the herpes simplex virus thymidine kinase gene to a new bromodeoxyuridine resistant variant of human primary lung carcinoma cells.
Carcinoma
Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".
Carcinoma
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
Carcinoma
Prognostic significance of thymidine kinase activity in bladder carcinoma.
Carcinoma
Properties of partially purified thymidine kinase in adrenal tissue of hyperplasia, adenomatous hyperplasia, adenoma and carcinoma of patients with Cushing's syndrome.
Carcinoma
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Carcinoma
Rana grylio virus as a vector for foreign gene expression in fish cells.
Carcinoma
Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats.
Carcinoma
Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.
Carcinoma
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Carcinoma
Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene.
Carcinoma
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Carcinoma
Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
Carcinoma
Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Carcinoma
Serological thymidine kinase 1 is a prognostic factor in oesophageal, cardial and lung carcinomas.
Carcinoma
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Carcinoma
Serum deoxythymidine kinase in small cell carcinoma of the lung. Relation to clinical features, prognosis, and other biochemical markers.
Carcinoma
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver.
Carcinoma
Serum thymidine kinase 1 is associated with Gleason score of patients with prostate carcinoma.
Carcinoma
Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.
Carcinoma
Serum thymidine kinase 1 reflects the progression of pre-malignant and malignant tumors during therapy.
Carcinoma
Serum thymidine kinase in diagnosis and follow-up of the small cell carcinoma of the lung.
Carcinoma
Significance of thymidine kinase activity in renal cell carcinoma.
Carcinoma
STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.
Carcinoma
Strategy for achieving selective killing of carcinomas.
Carcinoma
Structure-activity analysis of antagonism of the feedback inhibition of thymidine kinase.
Carcinoma
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Carcinoma
Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids.
Carcinoma
Synthetic radiation-inducible promoters mediated HSV-TK/GCV gene therapy in the treatment of oral squamous cell carcinoma.
Carcinoma
Targeted gene expression using a 1.1 kilobase promoter fragment of the tumour-associated antigen EpCAM.
Carcinoma
The effect of cyclic nucleotides on DNA polymerase, thymidylate synthetase, thymidine kinase and deoxynucleoside levels of Waler carcinoma.
Carcinoma
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.
Carcinoma
Thymidine Kinase 1 and Thymidine Phosphorylase Expression in Non-small Cell Lung Carcinoma in Relation to Angiogenesis and Proliferation.
Carcinoma
Thymidine kinase 1: a proliferation marker for determining prognosis and monitoring the surgical outcome of primary bladder carcinoma patients.
Carcinoma
Thymidine kinase activity in oral squamous cell carcinoma.
Carcinoma
Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker.
Carcinoma
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Carcinoma
Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT.
Carcinoma
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Carcinoma
Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.
Carcinoma
Transient increase in serum thymidine kinase 1 within one week after surgery of patients with carcinoma.
Carcinoma
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Carcinoma
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Carcinoma
Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter.
Carcinoma
Ultrastructure of hybrids derived from electric pulse fusion of human HeLa cells and murine 3T3.4E cells.
Carcinoma
Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cells.
Carcinoma
Use of gastrin-releasing peptide promoter for specific expression of thymidine kinase gene in small-cell lung carcinoma cells.
Carcinoma
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.
Carcinoma
[All-trans retinoic acid augments the bystander effect of herpes simplex virus thymidine kinase/ganciclovir system in the treatment of tongue carcinoma cell line]
Carcinoma
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
Carcinoma
[Comparative study of the transformation of various thymidine kinase-deficient human and animal cell lines with the thymidine kinase gene of the Herpes simplex virus]
Carcinoma
[Effects of hyperthermochemotherapy on activities of DNA-synthesizing enzymes in 1, 2-dimethylhydrazine (DMH)-induced colon carcinomas in rats]
Carcinoma
[Gene therapy of human pancreatic carcinoma by recombinant retroviral vector expressing herpes simplex virus thymidine kinase gene]
Carcinoma
[Studies on herpes simplex virus thymidine kinase gene and GCV system for treatment of human bladder carcinoma]
Carcinoma
[Studies on the thymidine-triphosphate synthesis in malignant tumors. I. Effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis (author's trans)]
Carcinoma
[Studies on the thymidine-triphosphate synthesis in malignant tumors. II. Effect of hyperthermia, Vitamin K and Cytotoxic agents (author's transl)]
Carcinoma
[The adenovirus-mediated HSV-TK/GCV suicide gene system in the treatment of tongue carcinoma cell line]
Carcinoma
[The killing effects of two prodrug sensitivity genes on human pancreatic carcinoma cells PC-2]
Carcinoma
[Use of the study of DNA metabolism enzyme activities as a test system in the treatment of breast cancer]
Carcinoma 256, Walker
Establishment and characterization of cell lines from the Walker carcinoma 256 able to grow in suspension culture and deficient in thymidine kinase.
Carcinoma, Adenoid Cystic
Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system.
Carcinoma, Adenoid Cystic
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Carcinoma, Ductal
Thymidine kinase 1 expression in atypical ductal hyperplasia significantly differs from usual ductal hyperplasia and ductal carcinoma in situ: A useful tool in tumor therapy management.
Carcinoma, Ehrlich Tumor
Characterization of the purified cytosolic thymidine kinase from murine ehrlich ascites tumor: interconversion of two different relative molecular weight forms.
Carcinoma, Ehrlich Tumor
Enzyme kinetics of thymidine kinase isoenzymes of Ehrlich ascites tumour.
Carcinoma, Ehrlich Tumor
Lack of correlation between thymidine kinase activity and changes of DNA synthesis with tumour age: an in vivo study in Ehrlich ascites tumour.
Carcinoma, Ehrlich Tumor
Thymidylate synthetase and thymidine kinase activities and methotrexate cytotoxicity during growth of L1210 and Ehrlich ascites tumor.
Carcinoma, Embryonal
Characteristics of the interferon system of an embryonal carcinomal cell are recessive in intraspecific somatic cell hybrids.
Carcinoma, Embryonal
Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells.
Carcinoma, Embryonal
DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells.
Carcinoma, Embryonal
Translational repression of endogenous thymidine kinase mRNA in differentiating and arresting mouse cells.
Carcinoma, Hepatocellular
5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma.
Carcinoma, Hepatocellular
A double suicide gene system driven by vascular endothelial growth factor promoter selectively kills human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver.
Carcinoma, Hepatocellular
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy combined with ganciclovir induces hepatoma cell apoptosis.
Carcinoma, Hepatocellular
Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma.
Carcinoma, Hepatocellular
An upstream element from the human insulin receptor gene promoter contains binding sites for C/EBP beta and NF-1.
Carcinoma, Hepatocellular
Analysis of thymidine kinase activity and glucocorticoid-binding capacity in the thymuses of healthy and tumor-bearing chickens.
Carcinoma, Hepatocellular
Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene.
Carcinoma, Hepatocellular
Assessment of ?-Fetoprotein Targeted HSV1-tk Expression in Hepatocellular Carcinoma with In Vivo Imaging.
Carcinoma, Hepatocellular
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Carcinoma, Hepatocellular
Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo.
Carcinoma, Hepatocellular
CC Ar GG boxes, cis-acting elements with a dual specificity. Muscle-specific transcriptional activation and serum responsiveness.
Carcinoma, Hepatocellular
Changes of tumor vascularity during gene therapy monitored with color Doppler US.
Carcinoma, Hepatocellular
Chicken ovalbumin upstream promoter-transcription factor, hepatocyte nuclear factor 3, and CCAAT/enhancer binding protein control the far-upstream enhancer of the rat alpha-fetoprotein gene.
Carcinoma, Hepatocellular
Comparative analysis of HPLC profile of cytosolic thymidine kinase activity between hepatoma and regenerating liver in rat with reference to phosphorylation.
Carcinoma, Hepatocellular
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene.
Carcinoma, Hepatocellular
Connexin32?mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity.
Carcinoma, Hepatocellular
Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells.
Carcinoma, Hepatocellular
Delineation of the insulin-responsive sequence in the rat cytosolic aspartate aminotransferase gene: binding sites for hepatocyte nuclear factor-3 and nuclear factor I.
Carcinoma, Hepatocellular
Differential expression of thymidine kinase gene in two subpopulations of a rat tumour correlates with their tumorigenic and cell division potential.
Carcinoma, Hepatocellular
DNA polymerase and thymidine kinase activities in MC-29 virus-induced transplantable hepatoma and the effect of cytostatic treatment of these activities.
Carcinoma, Hepatocellular
Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro.
Carcinoma, Hepatocellular
Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma.
Carcinoma, Hepatocellular
Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.
Carcinoma, Hepatocellular
Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment.
Carcinoma, Hepatocellular
Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
Carcinoma, Hepatocellular
Gene therapy for hepatocellular carcinoma based on tumour-selective suicide gene expression using the alpha-fetoprotein (AFP) enhancer and a housekeeping gene promoter.
Carcinoma, Hepatocellular
Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.
Carcinoma, Hepatocellular
Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter.
Carcinoma, Hepatocellular
Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir.
Carcinoma, Hepatocellular
Gene therapy of HSV-TK transferred by the EBV based expression vector on experimental hepatocellular carcinoma.
Carcinoma, Hepatocellular
Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences.
Carcinoma, Hepatocellular
Hepatoma-specific gene therapy through retrovirus-mediated and targeted gene transfer using an adenovirus carrying the ecotropic receptor gene.
Carcinoma, Hepatocellular
HSP90? combined with AFP and TK1 improved the diagnostic value for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
In vivo antitumor effect of herpes simplex virus thymidine kinase gene therapy in rat hepatocellular carcinoma: feasibility of adenovirus-mediated intra-arterial gene delivery.
Carcinoma, Hepatocellular
Increased concentration of thymidine kinase in rat hepatomas.
Carcinoma, Hepatocellular
Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Carcinoma, Hepatocellular
Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment.
Carcinoma, Hepatocellular
Inhibition of thymidine kinase activity in liver and hepatomas by TTP and d-CTP.
Carcinoma, Hepatocellular
Isolation and characterization of the rat gene for carbamoylphosphate synthetase I.
Carcinoma, Hepatocellular
Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro.
Carcinoma, Hepatocellular
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Carcinoma, Hepatocellular
Methotrexate decreases thymidine kinase activity.
Carcinoma, Hepatocellular
Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates.
Carcinoma, Hepatocellular
Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir.
Carcinoma, Hepatocellular
Negative regulation of the alpha-foetoprotein gene in fibroblasts: identification and characterization of cis and trans elements.
Carcinoma, Hepatocellular
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Carcinoma, Hepatocellular
Oncolytic vaccinia virus inhibits human hepatocellular carcinoma MHCC97-H cell proliferation via endoplasmic reticulum stress, autophagy and Wnt pathways.
Carcinoma, Hepatocellular
Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients.
Carcinoma, Hepatocellular
Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase.
Carcinoma, Hepatocellular
Protein-DNA interactions at a drug-responsive element of the human apolipoprotein A-I gene.
Carcinoma, Hepatocellular
Regulation of de novo and salvage pathways in chemotherapy.
Carcinoma, Hepatocellular
Retrovirus-mediated gene therapy for hepatocellular carcinoma with reversely oriented therapeutic gene expression regulated by alpha-fetoprotein enhancer/promoter.
Carcinoma, Hepatocellular
Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human alpha-fetoprotein enhancer directly linked to its promoter.
Carcinoma, Hepatocellular
Retrovirus-mediated gene therapy for human hepatocellular carcinoma transplanted in athymic mice.
Carcinoma, Hepatocellular
Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene.
Carcinoma, Hepatocellular
Serum thymidine kinase 1 protein concentration for predicting early progression and monitoring the response to TACE in hepatocellular carcinomas: a network meta-analysis.
Carcinoma, Hepatocellular
Some biochemical mechanisms underlying the impairment of T and B cell immunity in C3HA mice during hepatoma growth.
Carcinoma, Hepatocellular
SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo.
Carcinoma, Hepatocellular
Structural characteristics of cationic liposomes with potent enhancing effect on retroviral transduction into human hepatoma cells.
Carcinoma, Hepatocellular
Studies on thymidylate phosphatase, thymidine kinase and thymidylate kinase activities in some transplantable rat hepatomas.
Carcinoma, Hepatocellular
Suicide gene therapy for hepatocellular carcinoma cells by survivin promoter-driven expression of the herpes simplex virus thymidine kinase gene.
Carcinoma, Hepatocellular
Suicide gene therapy of hepatocellular carcinoma and delivery procedure and route of therapeutic gene in vivo.
Carcinoma, Hepatocellular
The distal enhancer implicated in the developmental regulation of the tyrosine aminotransferase gene is bound by liver-specific and ubiquitous factors.
Carcinoma, Hepatocellular
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
Carcinoma, Hepatocellular
The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha.
Carcinoma, Hepatocellular
The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPbeta.
Carcinoma, Hepatocellular
Thymidine transport in hepatocytes. An assay for hepatotoxicity.
Carcinoma, Hepatocellular
Tissue preference and differentiation of malignant rat x mouse hybrid cells in chimaeric mouse fetuses.
Carcinoma, Hepatocellular
Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice.
Carcinoma, Hepatocellular
Tumor-associated thymidine kinase in the sera of rats with transplanted hepatomas.
Carcinoma, Hepatocellular
Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice.
Carcinoma, Hepatocellular
Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase.
Carcinoma, Hepatocellular
Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Changes in DNA and purine nucleotide synthesis in lymphoid cells and sensitivity to glucocorticoids associated with the impairment of differentiation and immune function in mice during tumor growth. Spleen T- and B-lymphocytes]
Carcinoma, Hepatocellular
[Construction of a plasmid vector of fused protein genes driven by human insulin-like growth factor II P3 promoter]
Carcinoma, Hepatocellular
[Delivery of "suicide" thymidine kinase gene of herpes virus in the complex with cationic peptide into human hepatoma cells in vitro]
Carcinoma, Hepatocellular
[Effect of ultrasound microbubble carrying herpes simplex virus thymidine kinase on hepatocellular carcinoma in mice]
Carcinoma, Hepatocellular
[Mitochondrial thymidine kinase and ribonucleotide reductase from rat liver and rat hepatoma 27]
Carcinoma, Hepatocellular
[Thymidine kinase activity, intracellular TTP content and DNA synthesis in transplantable hepatomas and lymphoid tissue of the host]
Carcinoma, Intraductal, Noninfiltrating
Thymidine kinase 1 expression in atypical ductal hyperplasia significantly differs from usual ductal hyperplasia and ductal carcinoma in situ: A useful tool in tumor therapy management.
Carcinoma, Lewis Lung
Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth.
Carcinoma, Lewis Lung
Expression of thymidine kinase driven by an endothelial-specific promoter inhibits tumor growth of Lewis lung carcinoma cells in transgenic mice.
Carcinoma, Lewis Lung
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.
Carcinoma, Non-Small-Cell Lung
Ectopic expression of herpes simplex virus-thymidine kinase gene in human non-small cell lung cancer cells conferred caspase-activated apoptosis sensitized by ganciclovir.
Carcinoma, Non-Small-Cell Lung
Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.
Carcinoma, Non-Small-Cell Lung
Thymidine Kinase 1 and Thymidine Phosphorylase Expression in Non-small Cell Lung Carcinoma in Relation to Angiogenesis and Proliferation.
Carcinoma, Non-Small-Cell Lung
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Carcinoma, Ovarian Epithelial
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
Carcinoma, Ovarian Epithelial
Adenovirus-mediated thymidine kinase gene transduction in human epithelial ovarian cancer cell lines followed by exposure to ganciclovir.
Carcinoma, Ovarian Epithelial
Differences in thermostability of thymidine kinase isoenzymes in normal ovary and ovarian carcinoma.
Carcinoma, Ovarian Epithelial
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Carcinoma, Ovarian Epithelial
Human epithelial ovarian cancer xenotransplants into nude mice can be cured by adenovirus-mediated thymidine kinase gene therapy.
Carcinoma, Ovarian Epithelial
Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma.
Carcinoma, Ovarian Epithelial
Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model.
Carcinoma, Ovarian Epithelial
Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.
Carcinoma, Ovarian Epithelial
[Adenovirus-mediated herpes simplex virus thymidine kinase gene transference and combined drug therapy leads to apoptosis of human epithelial ovarian cancer cells]
Carcinoma, Ovarian Epithelial
[Targeted killing effect of mucin-1 single chain antibody targeting, lentivirus-mediated suicide gene therapy and ganciclovir in mucin-1+ ovarian epithelial carcinoma cells]
Carcinoma, Renal Cell
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Carcinoma, Renal Cell
Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model.
Carcinoma, Renal Cell
Exposed proliferation antigen 210 (XPA-210) in renal cell carcinoma (RCC) and oncocytoma: clinical utility and biological implications.
Carcinoma, Renal Cell
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
Carcinoma, Renal Cell
HSV-tk gene therapy for human renal cell carcinoma in nude mice.
Carcinoma, Renal Cell
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver.
Carcinoma, Renal Cell
Significance of thymidine kinase activity in renal cell carcinoma.
Carcinoma, Renal Cell
The Proliferation Marker Thymidine Kinase 1 Level is High in Normal Kidney Tubule Cells Compared to other Normal and Malignant Renal Cells.
Carcinoma, Renal Cell
Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker.
Carcinoma, Small Cell
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma, Small Cell
Serum deoxythymidine kinase in small cell carcinoma of the lung. Relation to clinical features, prognosis, and other biochemical markers.
Carcinoma, Small Cell
Serum thymidine kinase in diagnosis and follow-up of the small cell carcinoma of the lung.
Carcinoma, Squamous Cell
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Carcinoma, Squamous Cell
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Carcinoma, Squamous Cell
Enzyme activities in human fetal and neoplastic tissues.
Carcinoma, Squamous Cell
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
Carcinoma, Squamous Cell
HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect.
Carcinoma, Squamous Cell
In vivo transfer of a foreign gene to keratinocytes using the hemagglutinating virus of Japan-liposome method.
Carcinoma, Squamous Cell
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Carcinoma, Squamous Cell
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
Carcinoma, Squamous Cell
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma, Squamous Cell
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Carcinoma, Squamous Cell
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Carcinoma, Squamous Cell
The association of herpes simplex virus with squamous carcinoma of the cervix, and studies of the virus thymidine kinase gene.
Carcinoma, Squamous Cell
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Carcinoma, Squamous Cell
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
Carcinoma, Transitional Cell
Adenovirus-mediated suicide gene therapy for experimental bladder cancer.
Cardiomyopathies
Thymidine kinase 2 and alanyl-tRNA synthetase 2 deficiencies cause lethal mitochondrial cardiomyopathy: case reports and review of the literature.
Cardiomyopathies
Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.
Cardiomyopathy, Hypertrophic
Thymidine kinase 2 and alanyl-tRNA synthetase 2 deficiencies cause lethal mitochondrial cardiomyopathy: case reports and review of the literature.
Cell Transformation, Neoplastic
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Central Nervous System Neoplasms
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.
Central Nervous System Neoplasms
Preclinical testing of recombinant adenoviral herpes simplex virus-thymidine kinase gene therapy for central nervous system malignancies.
Chickenpox
Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine.
Chickenpox
Antibody responses to early antigens of varicella-zoster virus (VZV) during varicella and zoster.
Chickenpox
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.
Chickenpox
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects.
Chickenpox
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Chickenpox
Compartmentalization of acyclovir-resistant varicella zoster virus: implications for sampling in molecular diagnostics.
Chickenpox
Crystal structure of varicella zoster virus thymidine kinase.
Chickenpox
Development of immunogenic recombinant Oka varicella vaccine expressing hepatitis B virus surface antigen.
Chickenpox
Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants.
Chickenpox
Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome.
Chickenpox
Foscarnet salvage therapy for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of the literature.
Chickenpox
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Chickenpox
Highly purified recombinant varicella Zoster virus thymidine kinase is a homodimer.
Chickenpox
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
Chickenpox
Identification and analysis of the simian varicella virus thymidine kinase gene.
Chickenpox
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Chickenpox
Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an in-silico approach.
Chickenpox
In-vitro synthesis of functional varicella zoster and herpes simplex viral thymidine kinase.
Chickenpox
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.
Chickenpox
Metabolic suicide genes in gene therapy.
Chickenpox
Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.
Chickenpox
Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Chickenpox
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Chickenpox
Rapid sampling of multiple enzyme reactions.
Chickenpox
Regulated expression of artificial chimeric genes contained in retroviral vectors: implications for virus-directed enzyme prodrug therapy (VDEPT) and other gene therapy applications.
Chickenpox
Susceptibility of Oka varicella vaccine strain to antiviral drugs.
Chickenpox
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.
Chickenpox
Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.
Chickenpox
The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.
Chickenpox
The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
Chickenpox
Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62.
Chickenpox
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
Chickenpox
[Expression of the varicella zoster virus thymidine kinase and cytokines in patients with acute retinal necrosis syndrome]
Cholangiocarcinoma
Cholangiocarcinoma: molecular imaging-guided radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus thymidine kinase gene therapy.
Cholangiocarcinoma
Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study.
Chondrosarcoma
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Chondrosarcoma
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Choriocarcinoma
Coordination of transcription of the human 17 beta-hydroxysteroid dehydrogenase type 1 gene (EDH17B2) by a cell-specific enhancer and a silencer: identification of a retinoic acid response element.
Choriocarcinoma
The human chorionic somatomammotropin gene enhancer is composed of multiple DNA elements that are homologous to several SV40 enhansons.
Choriocarcinoma
The POU homeodomain protein Oct-1 binds Cis-regulatory element essential for the human GnRH upstream promoter activity in JEG-3 cells.
Classical Swine Fever
Experimental quantification of transmission of genetically engineered pseudorabies virus.
Classical Swine Fever
Role of viral proteins and concanavalin A in in vitro replication of pseudorabies virus in porcine peripheral blood mononuclear cells.
Coinfection
Construction of an infectious clone of canine herpesvirus genome as a bacterial artificial chromosome.
Colitis
Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis.
Colitis
Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice.
Colonic Neoplasms
Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases.
Colonic Neoplasms
Affinity chromatography of thymidine kinase from a rat colon adenocarcinoma.
Colonic Neoplasms
Anti-tumor effects of engineered mesenchymal stem cells in colon cancer model.
Colonic Neoplasms
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Colonic Neoplasms
Antitumor Therapy Based on Cellular Competition.
Colonic Neoplasms
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Colonic Neoplasms
Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.
Colonic Neoplasms
Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency.
Colonic Neoplasms
Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage.
Colonic Neoplasms
Gene therapy for colon cancer with the herpes simplex thymidine kinase gene.
Colonic Neoplasms
Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
Colonic Neoplasms
Herpes simplex thymidine kinase gene transfer is required for complete regression of murine colon adenocarcinoma.
Colonic Neoplasms
Herpes simplex virus thymidine kinase and granulocyte macrophage colony-stimulating factor combination gene therapy in a murine CT26 cell colon cancer model.
Colonic Neoplasms
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.
Colonic Neoplasms
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs.
Colonic Neoplasms
Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate.
Colonic Neoplasms
In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery.
Colonic Neoplasms
Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms.
Colonic Neoplasms
Kinetic properties of thymidine kinase from the cytosol of a rat colon adenocarcinoma.
Colonic Neoplasms
Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging.
Colonic Neoplasms
Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells.
Colonic Neoplasms
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
Colonic Neoplasms
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Colonic Neoplasms
Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells.
Colonic Neoplasms
Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.
Colonic Neoplasms
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Colonic Neoplasms
The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene.
Colonic Neoplasms
Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase.
Colonic Neoplasms
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
Colonic Neoplasms
[Clinical significance of DNA-synthesizing enzyme, thymidine kinase, in human colonic cancer]
Colonic Neoplasms
[The effect of UFT on thymidine kinase and thymidylate synthetase activities and autoradiograph in DMH-induced colon cancer in rat]
Colorectal Neoplasms
A meta-analysis of serological thymidine kinase 1 as a marker for colorectal benign and malignant tumor risk assessment.
Colorectal Neoplasms
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma.
Colorectal Neoplasms
Ablation of tumor cells in vivo by direct injection of HSV-thymidine kinase retroviral vector and ganciclovir therapy.
Colorectal Neoplasms
Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns.
Colorectal Neoplasms
Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer.
Colorectal Neoplasms
Antitumor effects and radiosensitization of cytosine deaminase and thymidine kinase fusion suicide gene on colorectal carcinoma cells.
Colorectal Neoplasms
Cell death associated with genetic prodrug activation therapy of colorectal cancer.
Colorectal Neoplasms
Changes of thymidine kinase (TK) during adjuvant and palliative chemotherapy.
Colorectal Neoplasms
Clinical Significance and Role of TK1, CEA, CA 19-9 and CA 72-4 levels in Diagnosis of Colorectal Cancers.
Colorectal Neoplasms
Correlations of (18)F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase 1 expressions in primary and metastatic lymph node colorectal cancer foci.
Colorectal Neoplasms
Effects of 5-fluorouracil derivative UFT on thymidylate synthetase and thymidine kinase in rat colorectal tumors.
Colorectal Neoplasms
Effects of a low dose leucovorin with 5-fluorouracil derivative on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Colorectal Neoplasms
Effects of carcinogenesis on colonic thymidine kinase activity in familial adenomatous polyposis.
Colorectal Neoplasms
Effects of CO2 pneumoperitoneum on the expression of thymidine kinase 1 and Ki67 in colorectal carcinoma cells.
Colorectal Neoplasms
Human colorectal malignancy and oral UFT.
Colorectal Neoplasms
Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation.
Colorectal Neoplasms
Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.
Colorectal Neoplasms
Overexpression of m-calpain in human colorectal adenocarcinomas.
Colorectal Neoplasms
Positron emission tomography imaging of human colon cancer xenografts in mice with [18F]fluorothymidine after TAS-102 treatment.
Colorectal Neoplasms
Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors.
Colorectal Neoplasms
Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials.
Colorectal Neoplasms
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Colorectal Neoplasms
Serum thymidine kinase in colorectal neoplasia.
Colorectal Neoplasms
Suppression of Cancer Growth by Nonviral Gene Therapy Based on a Novel Reactive Oxygen Species-responsive Promoter.
Colorectal Neoplasms
The Association of Serum Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Thymidine Kinase, and Tissue Polypeptide Specific Antigen with Outcomes of Patients with Metastatic Colorectal Cancer Treated with Bevacizumab: a Retrospective Study.
Colorectal Neoplasms
The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway.
Colorectal Neoplasms
Thymidine Kinase 1 Loss Confers Trifluridine Resistance without Affecting 5-Fluorouracil Metabolism and Cytotoxicity.
Colorectal Neoplasms
Thymidine kinase activity in familial adenomatous polyposis.
Colorectal Neoplasms
Tumor markers in staging and prognosis of colorectal carcinoma.
Colorectal Neoplasms
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Colorectal Neoplasms
[Clinical value of thymidine kinase activities in sera and tumor tissues of patients with colorectal cancer]
Colorectal Neoplasms
[Cytosine deaminase and thymidine kinase double suicide gene system driven by carcinoembryonic antigen promoter for the treatment of colorectal carcinoma xenograft in nude mice].
Colorectal Neoplasms
[Experimental treatment for human colorectal carcinoma by tissue type specific expression of herpes simplex virus thymidine kinase gene]
Communicable Diseases
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
Coronary Restenosis
Gene therapy for ischemic heart disease.
Cowpox
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Cowpox
Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates.
Cowpox
Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.
Cowpox
KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.
Cowpox
Orthopoxvirus DNA in eurasian lynx, sweden.
Cryptorchidism
Alterations in activities of calmodulin and heat-stable calmodulin-binding protein in rat testis.
Cushing Syndrome
Properties of partially purified thymidine kinase in adrenal tissue of hyperplasia, adenomatous hyperplasia, adenoma and carcinoma of patients with Cushing's syndrome.
Cystic Fibrosis
Altered binding of 125I-labeled calmodulin to a 46.5-kilodalton protein in skin fibroblasts cultured from patients with cystic fibrosis.
Cysts
Thymidine kinase in brain-tumor cysts.
Cytomegalovirus Infections
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Cytomegalovirus Infections
Serum thymidine kinase in transplant patients: its relation to cytomegalovirus activity, renal transplant rejection and its use for monitoring of antiviral therapy.
Cytomegalovirus Infections
Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice.
Cytomegalovirus Infections
[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections.
Dementia
Mitochondrial disorders, cognitive impairment and dementia.
Dermatitis, Allergic Contact
Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model.
Diabetes Mellitus
Relationship between thymidine kinase 1 before radiotherapy and prognosis in breast cancer patients with diabetes.
Diabetes Mellitus, Type 1
Multimodality Imaging of {beta}-Cells in Mouse Models of Type I and II Diabetes.
Diabetes Mellitus, Type 2
Relationship between thymidine kinase 1 before radiotherapy and prognosis in breast cancer patients with diabetes.
diacylglycerol kinase (atp) deficiency
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity.
Diphtheria
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme.
Diphtheria
Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection maker.
Diphtheria
Isolation of diphtheria toxin-sensitive mouse cells from a toxin-resistant population transfected with monkey DNA.
Diphtheria
Use of H19 regulatory sequences for targeted gene therapy in cancer.
Down Syndrome
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Ectodermal Dysplasia
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Ectromelia
Fine mechanisms of ectromelia virus thymidine kinase-negative mutants avirulence.
Encephalitis
Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported.
Encephalitis
Asymptomatic herpes simplex type 1 virus infection of the mouse brain.
Encephalitis
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Encephalitis
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
Encephalitis
Diagnosis of herpes encephalitis via Southern blotting of cerebrospinal fluid DNA amplified by polymerase chain reaction.
Encephalitis
Effect of combinations of antiviral drugs on herpes simplex encephalitis.
Encephalitis
Nucleotide and amino acid sequence analysis of the thymidine kinase gene of a bovine encephalitis herpesvirus.
Encephalitis
Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
Encephalitis
Thymidine kinase activity in cerebrospinal fluid of rabbits with Herpesvirus hominis encephalitis.
Encephalitis
Use of the polymerase chain reaction to detect herpes simplex virus DNA in paraffin sections of human brain at necropsy.
Encephalitis, Herpes Simplex
Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported.
Encephalitis, Herpes Simplex
Diagnosis of herpes encephalitis via Southern blotting of cerebrospinal fluid DNA amplified by polymerase chain reaction.
Encephalitis, Herpes Simplex
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.
Encephalitis, Japanese
Induction of protective immunity in animals vaccinated with recombinant vaccinia viruses that express PreM and E glycoproteins of Japanese encephalitis virus.
Encephalomyelitis, Venezuelan Equine
Recombinant vaccinia/Venezuelan equine encephalitis (VEE) virus expresses VEE structural proteins.
Encephalomyelitis, Venezuelan Equine
[The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus]
Endodermal Sinus Tumor
Protein synthesis and tumorigenicity of the cytoplasmic hybrid between rat yolk sac tumor and mouse fibroblastic cell line.
Endometrial Neoplasms
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Enzootic Bovine Leukosis
Overexpression of interleukin 2 receptor, thymidine kinase and immunoglobulin-associated alpha-1 messenger RNA in a clinical case of enzootic bovine leukosis.
Enzootic Bovine Leukosis
Serum thymidine kinase activity as a useful marker for bovine leukosis.
Enzootic Bovine Leukosis
Utility of Serum Thymidine Kinase Activity Measurements for Cases of Bovine Leukosis with Difficult Clinical Diagnoses.
Ependymoma
Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient.
Epilepsy
An A8296G mutation in the MT-TK gene of a patient with epilepsy - a disease-causing mutation or rare polymorphism?
Epilepsy
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Epstein-Barr Virus Infections
Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies.
Erythema Multiforme
Expression of herpes simplex virus DNA fragments located in epidermal keratinocytes and germinative cells is associated with the development of erythema multiforme lesions.
Esophageal Neoplasms
Thymidine kinase 1 is a potential marker for prognosis and monitoring the response to treatment of patients with breast, lung, and esophageal cancer and non-Hodgkin's lymphoma.
Esophageal Squamous Cell Carcinoma
Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.
Exanthema
Thymidine kinase sequence analysis of herpes simplex virus type 1 strains present in different compartments in an atypical impetiginous rash on the lesional skin of a burn patient.
Eye Infections
The role of herpesvirus type 1 thymidine kinase in experimental ocular infections.
Eye Infections
Thymidine kinase and susceptibility to interferon are not involved in the increased virulence of recombinant viruses isolated following mixed ocular infection with HSV strains OD4 and CJ394.
Feline Panleukopenia
Raccoon poxvirus live recombinant feline panleukopenia virus VP2 and rabies virus glycoprotein bivalent vaccine.
Fibroadenoma
Increased activities of thymidine kinase isozymes in human mammary tumours.
Fibroma
Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides.
Fibrosarcoma
In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU.
Fibrosarcoma
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Filariasis
Insights into the structure-function relationship of Brugia malayi thymidylate kinase (BmTMK).
Fowlpox
Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene.
Fowlpox
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Fowlpox
Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases.
Fowlpox
Gene translocations in poxviruses: the fowlpox virus thymidine kinase gene is flanked by 15 bp direct repeats and occupies the locus which in vaccinia virus is occupied by the ribonucleotide reductase large subunit gene.
Fowlpox
Identification and cloning of the fowlpox virus thymidine kinase gene using vaccinia virus.
Fowlpox
Identification of the canarypox virus thymidine kinase gene and insertion of foreign genes.
Fowlpox
Quaternary structure of vaccinia virus thymidine kinase.
Fowlpox
Role of the fowlpox virus thymidine kinase gene for the growth of FPV recombinants in cell culture.
Fowlpox
Similar genetic organization between a region of fowlpox virus DNA and the vaccinia virus HindIII J fragment despite divergent location of the thymidine kinase gene.
Fowlpox
Structural analysis of unstable intermediate and stable forms of recombinant fowlpox virus.
Fowlpox
Studies of fowlpox virus recombination in the generation of recombinant vaccines.
Fowlpox
Vaccination of chickens with a recombinant fowlpox virus containing the hemagglutinin-neuraminidase gene of Newcastle disease virus under the control of the fowlpox virus thymidine kinase promoter.
galactokinase deficiency
Cytosolic thymidine kinase activity in cultured human fibroblasts from individuals with galactokinase deficiency.
galactokinase deficiency
Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency.
galactokinase deficiency
Thymidine kinase activity in individuals with galactokinase deficiency.
galactokinase deficiency
Thymidine-kinase activity of cultured cells from individuals with inherited galactokinase deficiency.
Galactosemias
Cytosolic thymidine kinase activity in cultured human fibroblasts from individuals with galactokinase deficiency.
Galactosemias
Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency.
Galactosemias
Thymidine kinase activity in individuals with galactokinase deficiency.
Galactosemias
Thymidine-kinase activity of cultured cells from individuals with inherited galactokinase deficiency.
Gallbladder Neoplasms
E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer.
Gastroenteritis
Absence of a cAMP-mediated antiabsorptive effect in an undifferentiated jejunal epithelium.
Gastroenteritis
Intracellular processing of the porcine coronavirus transmissible gastroenteritis virus spike protein expressed by recombinant vaccinia virus.
Gastroenteritis, Transmissible, of Swine
Intracellular processing of the porcine coronavirus transmissible gastroenteritis virus spike protein expressed by recombinant vaccinia virus.
Gastrointestinal Diseases
Thymidine kinase in breast cancer.
Gastrointestinal Neoplasms
Correlation of 18F-FLT uptake with equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in gastrointestinal cancer.
Gastrointestinal Neoplasms
Expression and Clinical Significance of Cytokeratin-19 and Thymidine Kinase-1 in Advanced Gastrointestinal Cancer.
Glioblastoma
A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells as a Novel Carrier for Suicide Gene Delivery.
Glioblastoma
A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment.
Glioblastoma
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group.
Glioblastoma
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma.
Glioblastoma
A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.
Glioblastoma
Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial.
Glioblastoma
Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.
Glioblastoma
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Glioblastoma
Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43.
Glioblastoma
Clinical protocol. Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme.
Glioblastoma
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase.
Glioblastoma
Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy.
Glioblastoma
Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma.
Glioblastoma
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Glioblastoma
Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma.
Glioblastoma
Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.
Glioblastoma
Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.
Glioblastoma
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Glioblastoma
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.
Glioblastoma
Encapsulation of packaging cell line results in successful retroviral-mediated transfer of a suicide gene in vivo in an experimental model of glioblastoma.
Glioblastoma
Experimental therapy of allogeneic solid tumors induced in athymic mice with suicide gene-transducing replication-competent foamy virus vectors.
Glioblastoma
Gene stereotactic neurosurgery for recurrent malignant gliomas.
Glioblastoma
Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir.
Glioblastoma
Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.
Glioblastoma
Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect.
Glioblastoma
HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.
Glioblastoma
HSV-TK/IL-2 gene therapy for glioblastoma multiforme.
Glioblastoma
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
Glioblastoma
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma.
Glioblastoma
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models.
Glioblastoma
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Glioblastoma
Peptide Micelle-Mediated Delivery of Tissue-Specific Suicide Gene and Combined Therapy with Avastin in a Glioblastoma Model.
Glioblastoma
Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside.
Glioblastoma
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Glioblastoma
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Glioblastoma
Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells.
Glioblastoma
Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.
Glioblastoma
Reducible Poly(Oligo-D-Arginine) as an Efficient Carrier of the Thymidine Kinase Gene in the Intracranial Glioblastoma Animal Model.
Glioblastoma
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Glioblastoma
Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome.
Glioblastoma
Thymidine kinase gene delivery using curcumin loaded peptide micelles as a combination therapy for glioblastoma.
Glioblastoma
Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene.
Glioblastoma
Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial.
Glioma
8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET.
Glioma
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
Glioma
A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells.
Glioma
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.
Glioma
A novel bi-cistronic high-capacity gutless adenovirus vector driving constitutive expression of HSV1-TK and Tet-inducible expression of Flt3L for glioma therapeutics.
Glioma
A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro(R)) after intracerebral administration.
Glioma
A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.
Glioma
Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir.
Glioma
Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intracerebrally implanted human gliomas in mice, in conjunction with ganciclovir administration.
Glioma
Adenoviral-mediated gene transfer into the canine brain in vivo.
Glioma
Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies.
Glioma
Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma.
Glioma
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model.
Glioma
Antagonism of HSV-tk transfection and ganciclovir treatment on chemotherapeutic drug sensitivity.
Glioma
Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models.
Glioma
Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy.
Glioma
Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy.
Glioma
Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.
Glioma
Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.
Glioma
Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cells.
Glioma
Calmodulin-binding proteins in human Y-79 retinoblastoma and HTB-14 glioma cell lines.
Glioma
Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models.
Glioma
Cellular influx, efflux, and anabolism of 3-carboranyl thymidine analogs: Potential boron delivery agents for neutron capture therapy.
Glioma
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Glioma
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
Glioma
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Glioma
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Glioma
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Glioma
Comparison of [(14)C]FMAU, [(3)H]FEAU, [(14)C]FIAU, and [(3)H]PCV for Monitoring Reporter Gene Expression of Wild Type and Mutant Herpes Simplex Virus Type 1 Thymidine Kinase in Cell Culture.
Glioma
Correlation of 4'-[methyl-11C]-thiothymidine uptake with human equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in patients with newly diagnosed gliomas.
Glioma
Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.
Glioma
Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma.
Glioma
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate.
Glioma
Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells.
Glioma
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Glioma
Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect".
Glioma
Efficacy of the bystander effect in the herpes simplex virus thymidine kinase-mediated gene therapy is influenced by the expression of connexin43 in the target cells.
Glioma
Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.
Glioma
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.
Glioma
Evaluation of 3'-deoxy-3'-[18F]-fluorothymidine (18F-FLT) kinetics correlated with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas.
Glioma
Evaluation of TK1 targeting carboranyl thymidine analogs as potential delivery agents for neutron capture therapy of brain tumors.
Glioma
Expression of thymidine kinase is essential to low dose radiation resistance of rat glioma cells.
Glioma
Gene therapy for brain tumors.
Glioma
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.
Glioma
Gene therapy for pediatric brain tumors.
Glioma
Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging.
Glioma
Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells.
Glioma
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-?B signaling improves the efficacy of immunotherapy in a brain cancer model.
Glioma
Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas.
Glioma
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Glioma
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
Glioma
Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models.
Glioma
Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice.
Glioma
Human NT2 Neural Precursor-Derived Tumor-Infiltrating Cells as Delivery Vehicles for Treatment of Glioblastoma.
Glioma
Image-guided control of transgene expression based on local hyperthermia.
Glioma
Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.
Glioma
Imaging the expression of transfected genes in vivo.
Glioma
In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.
Glioma
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
Glioma
In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene.
Glioma
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha.
Glioma
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
Glioma
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.
Glioma
Increased bax expression is associated with cell death induced by ganciclovir in a herpes thymidine kinase gene-expressing glioma cell line.
Glioma
Inflammatory thoughts about glioma gene therapy.
Glioma
Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter.
Glioma
Integration of adenovirus thymidine kinase suicide-gene therapy with surgery and radiation therapy for malignant glioma.
Glioma
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Glioma
Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response.
Glioma
Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment.
Glioma
Liposomal delivery of the herpes simplex virus thymidine kinase gene in glioma: improvement of cell sensitization to ganciclovir.
Glioma
Local inflammation and devascularization--in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma.
Glioma
Local tumour irradiation enhances the anti-tumour effect of a double-suicide gene therapy system in a murine glioma model.
Glioma
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Glioma
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma.
Glioma
Microglia used as vehicles for both inducible thymidine kinase gene therapy and MRI contrast agents for glioma therapy.
Glioma
Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas.
Glioma
miR-145 is a potential biomarker for predicting clinical outcome in glioblastomas.
Glioma
Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.
Glioma
Molecular imaging of brain tumors personal experience and review of the literature.
Glioma
Molecular imaging of gliomas.
Glioma
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging.
Glioma
New Variants of Tomato Thymidine Kinase 1 Selected for Increased Sensitivity of E. coli KY895 towards Azidothymidine.
Glioma
Noninvasive and Local Delivery of Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase to Treat Glioma Through Focused Ultrasound-Induced Blood-Brain Barrier Opening in Rats.
Glioma
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Glioma
Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma.
Glioma
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Glioma
Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.
Glioma
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
Glioma
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
Glioma
Potent bystander effect in suicide gene therapy using neural stem cells transduced with herpes simplex virus thymidine kinase gene.
Glioma
Prognostic utility of gene therapy with herpes simplex virus thymidine kinase for patients with high-grade malignant gliomas: a systematic review and meta analysis.
Glioma
Quantitative kinetics of [124I]FIAU in cat and man.
Glioma
Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus.
Glioma
Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion.
Glioma
Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment.
Glioma
Recent advances in experimental molecular therapeutics for malignant gliomas.
Glioma
Retroviral transfer of herpes simplex thymidine kinase gene into glioma cells causes targeting of gancyclovir cytotoxic effect.
Glioma
Retroviruses and DNA: gene therapy for brain tumours.
Glioma
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Glioma
Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression.
Glioma
Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene.
Glioma
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Glioma
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Glioma
Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma.
Glioma
Studies on interactions of dTK-HSV mutants with neurons in vitro.
Glioma
The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells.
Glioma
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
Glioma
The inhibition of thymidine kinase in glial tumor cells by an amino sugar, D-glucosamine.
Glioma
The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors.
Glioma
Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.
Glioma
Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study.
Glioma
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
Glioma
Tomato thymidine kinase is subject to inefficient TTP feedback regulation.
Glioma
Toxicity studies in thymidine kinase-deficient herpes simplex virus therapy for malignant astrocytoma.
Glioma
Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene.
Glioma
Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase.
Glioma
Treatment of rat gliomas with recombinant retrovirus harboring Herpes simplex virus thymidine kinase suicide gene.
Glioma
Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir.
Glioma
Use of thymidine kinase gene-modified endothelial progenitor cells as a vector targeting angiogenesis in glioma gene therapy.
Glioma
Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: myelin basic protein promoter is strongly active in human malignant glioma cells.
Glioma
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Glioma
Valproic acid enhances anti-tumor effect of mesenchymal stem cell mediated HSV-TK gene therapy in intracranial glioma.
Glioma
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho.
Glioma
[Antiglioma activity of endothelial progenitor cells transduced with HSV-TK via inhibiting angiogenesis in vitro and in vivo.]
Glioma
[PET-MR in patients with glioblastoma multiforme].
Glioma
[Selective gene therapy of malignant gliomas using brain-specific promoters: its efficacy and basic investigations]
Glioma
[Synergistic effect of all-trans retinoic acid and herpes simplex virus thymidine kinase gene on glioma]
Gliosarcoma
Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy.
Gliosarcoma
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Gliosarcoma
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Gliosarcoma
Gamma interferon transduced 9L gliosarcoma. Cytokine gene therapy and its relevance to cellular therapy with alloreactive cytotoxic T lymphocytes.
Gliosarcoma
Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity.
Gliosarcoma
Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors.
Gliosarcoma
Imaging expression of adenoviral HSV1-tk suicide gene transfer using the nucleoside analogue FIRU.
Gliosarcoma
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Gliosarcoma
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Gliosarcoma
Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms.
Gliosarcoma
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.
Gliosarcoma
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Gliosarcoma
Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.
Gliosarcoma
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Gliosarcoma
Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.
Glucose Intolerance
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.
Glycogen Storage Disease Type II
Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle.
Graft vs Host Disease
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation.
Graft vs Host Disease
Canine T cells transduced with a herpes simplex virus thymidine kinase gene: a model to study effects on engraftment and control of graft-versus-host disease.
Graft vs Host Disease
Cellular engineering of HSV-tk transduced, expanded T lymphocytes for graft-versus-host disease management.
Graft vs Host Disease
Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft.
Graft vs Host Disease
Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene.
Graft vs Host Disease
Efficient transduction and selection of human T-lymphocytes with bicistronic Thy1/HSV1-TK retroviral vector produced by a human packaging cell line.
Graft vs Host Disease
Extensive vitiligo after ganciclovir treatment of GvHD in a patient who had received donor T cells expressing herpes simplex virus thymidine kinase.
Graft vs Host Disease
Gene therapy strategies for leukemia.
Graft vs Host Disease
Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene.
Graft vs Host Disease
Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors.
Graft vs Host Disease
Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation.
Graft vs Host Disease
Immunological defects after suicide gene therapy of experimental graft-versus-host disease.
Graft vs Host Disease
Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.
Graft vs Host Disease
Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene.
Graft vs Host Disease
Monitoring of developing graft-versus-host disease mediated by herpes simplex virus thymidine kinase gene-transduced T cells.
Graft vs Host Disease
Preservation of graft-versus-infection effects after suicide gene therapy for prevention of graft-versus-host disease.
Graft vs Host Disease
Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene.
Graft vs Host Disease
Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire.
Graft vs Host Disease
Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease.
Hashimoto Disease
Expression of genes for certain enzymes of pyrimidine and purine salvage pathway in peripheral blood leukocytes collected from patients with Graves' or Hashimoto's disease.
Head and Neck Neoplasms
Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.
Head and Neck Neoplasms
Clinical Applicability of the Proliferation Marker Thymidine Kinase 1 in Head and Neck Cancer Patients.
Head and Neck Neoplasms
Combination gene therapy for oral cancer in a murine model.
Head and Neck Neoplasms
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors.
Head and Neck Neoplasms
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Head and Neck Neoplasms
Silk-elastin-like hydrogel improves the safety of adenovirus-mediated gene-directed enzyme-prodrug therapy.
Head and Neck Neoplasms
The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer.
Head and Neck Neoplasms
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Hearing Loss
Analysis of mitochondrial alterations in Brazilian patients with sensorineural hearing loss using MALDI-TOF mass spectrometry.
Heart Diseases
Autoradiography study and SPECT imaging of reporter gene HSV1-tk expression in heart.
Hematologic Diseases
Thymidine kinase activity in the human bone marrow from various blood diseases.
Hematologic Neoplasms
Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation.
Hematologic Neoplasms
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker.
Hematologic Neoplasms
Erratum to: Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Hematologic Neoplasms
Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Hematologic Neoplasms
NeoR-based transduced T lymphocytes detected by real-time quantitative polymerase chain reaction.
Hematologic Neoplasms
Ribonucleotide reductase and thymidine kinase activities in various cultured cell lines derived from hematologic malignancies.
Hematologic Neoplasms
Serum thymidine kinase activity as a useful marker for bovine leukosis.
Hematologic Neoplasms
Serum thymidine kinase as a marker of disease activity in patients with multiple myeloma.
Hematologic Neoplasms
Serum thymidine kinase in hematologic malignancies.
Hematologic Neoplasms
T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation.
Hepatitis
Elevated serum thymidine kinase activity in patients with acute viral hepatitis.
Hepatitis
Origin of thymidine kinase in the cells infected with infectious canine hepatitis virus.
Hepatitis
Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy.
Hepatitis
Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.
Hepatitis A
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Hepatitis B
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
Hepatitis B
Construction of Oka varicella vaccine expressing human immunodeficiency virus env antigen.
Hepatitis B
Development of immunogenic recombinant Oka varicella vaccine expressing hepatitis B virus surface antigen.
Hepatitis B
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.
Hepatitis B
Improved recombinant LC16m0 or LC16m8 vaccinia virus successfully expressing hepatitis B surface antigen.
Hepatitis B
Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.
Hepatitis B
Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
Hepatitis B
Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA.
Hepatitis B
Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes.
Hepatitis B
[Double recombinants of the vaccinia virus expressing hepatitis B virus surface antigen and herpes simplex virus thymidine kinase]
Hepatitis C
Improved gene expression by a modified bicistronic retroviral vector.
Hepatitis E
Sexual Dimorphism in Hepatocyte Xenograft Models.
Hepatitis, Infectious Canine
Origin of thymidine kinase in the cells infected with infectious canine hepatitis virus.
Herpes Genitalis
Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.
Herpes Genitalis
Thymidine kinase-deficient herpes simplex virus type 2 genital infection in guinea pigs.
Herpes Simplex
"Suicide" gene for the control of graft-versus-host disease.
Herpes Simplex
"Suicide" gene therapy of breast cancer cells is only cytostatic in vitro but anti-tumoral in vivo on breast MCF7-ras tumor.
Herpes Simplex
"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.
Herpes Simplex
'Bystander killing' induces apoptosis and is inhibited by forskolin.
Herpes Simplex
(3)H-Penciclovir ((3)H-PCV) Uptake Assay.
Herpes Simplex
(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
Herpes Simplex
(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity.
Herpes Simplex
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.
Herpes Simplex
18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers.
Herpes Simplex
2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent.
Herpes Simplex
2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase.
Herpes Simplex
207 engineered human amniotic fluid-derived stem cells by expressing Cytosine deaminase (cd) and thymidine kinase (hsv-tk) mediate targeting killing effect in breast cancer cells.
Herpes Simplex
3'-Amino thymidine affinity matrix for the purification of herpes simplex virus thymidine kinase.
Herpes Simplex
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
Herpes Simplex
5-Azacytidine-induced reactivation of a herpes simplex thymidine kinase gene.
Herpes Simplex
5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
Herpes Simplex
5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies.
Herpes Simplex
5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression.
Herpes Simplex
8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET.
Herpes Simplex
9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication.
Herpes Simplex
9-(4-Hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, suppresses herpes virus reactivation in mice.
Herpes Simplex
9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.
Herpes Simplex
A "distant" bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor.
Herpes Simplex
A 2.7-kb portion of the 5' flanking region of the murine glycoprotein alphaIIb gene is transcriptionally active in primitive hematopoietic progenitor cells.
Herpes Simplex
A 211-bp enhancer of the rat uncoupling protein-1 (UCP-1) gene controls specific and regulated expression in brown adipose tissue.
Herpes Simplex
A beta-galactosidase expression vector for promoter analysis.
Herpes Simplex
A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone.
Herpes Simplex
A CACCC box-like cis-regulatory element of the Epstein-Barr virus ED-L2 promoter interacts with a novel transcriptional factor in tissue-specific squamous epithelia.
Herpes Simplex
A calcium ionophore-inducible cellular promoter is highly active and has enhancerlike properties.
Herpes Simplex
A candidate live inactivatable attenuated vaccine for AIDS.
Herpes Simplex
A cell cycle model for the tachyzoite of Toxoplasma gondii using the Herpes simplex virus thymidine kinase.
Herpes Simplex
A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect.
Herpes Simplex
A closed culture system for the ex vivo transduction and expansion of human T lymphocytes.
Herpes Simplex
A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy.
Herpes Simplex
A common set of nuclear factors bind to promoter elements regulated by the retinoblastoma protein.
Herpes Simplex
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
Herpes Simplex
A comparison of transcriptional regulatory element activities in transformed and non-transformed rat anterior pituitary cells.
Herpes Simplex
A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter.
Herpes Simplex
A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
Herpes Simplex
A cryptic transcription promoter in the myb oncogene of avian myeloblastosis virus.
Herpes Simplex
A designed curved DNA segment that is a remarkable activator of eukaryotic transcription.
Herpes Simplex
A DNA recombination-based approach to eliminate papillomavirus infection.
Herpes Simplex
A DNA segment controlling metal-regulated expression of the Drosophila melanogaster metallothionein gene Mtn.
Herpes Simplex
A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.
Herpes Simplex
A dominant positive and negative selectable gene for use in mammalian cells.
Herpes Simplex
A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice.
Herpes Simplex
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
Herpes Simplex
A dual selection based, targeted gene replacement tool for Magnaporthe grisea and Fusarium oxysporum.
Herpes Simplex
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease.
Herpes Simplex
A fast method for obtaining highly pure recombinant herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells.
Herpes Simplex
A fully automated one pot synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl) guanine for gene therapy studies.
Herpes Simplex
A functional selection of viral genetic elements in cultured cells to identify hepatitis C virus RNA translation inhibitors.
Herpes Simplex
A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells.
Herpes Simplex
A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase.
Herpes Simplex
A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes.
Herpes Simplex
A generalized technique for deletion of specific genes in large genomes: alpha gene 22 of herpes simplex virus 1 is not essential for growth.
Herpes Simplex
A genetic approach to promoter recognition during trans induction of viral gene expression.
Herpes Simplex
A guanylate kinase/HSV-1 thymidine kinase fusion protein enhances prodrug-mediated cell killing.
Herpes Simplex
A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis.
Herpes Simplex
A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals.
Herpes Simplex
A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.
Herpes Simplex
A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.
Herpes Simplex
A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides.
Herpes Simplex
A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NFI and a novel transcription factor, mammary cell-activating factor.
Herpes Simplex
A matched set of cat vectors for rapid mutational analysis of eukaryotic promoters and enhancers.
Herpes Simplex
A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir.
Herpes Simplex
A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target.
Herpes Simplex
A modified human Myogenin promoter that is highly active in alveolar rhabdomyosarcoma.
Herpes Simplex
A Mup promoter-thymidine kinase reporter gene shows relaxed tissue-specific expression and confers male sterility upon transgenic mice.
Herpes Simplex
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.
Herpes Simplex
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.
Herpes Simplex
A negative element involved in vimentin gene expression.
Herpes Simplex
A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA.
Herpes Simplex
A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.
Herpes Simplex
A neuroblastoma-selective suicide gene therapy approach using the tyrosine hydroxylase promoter.
Herpes Simplex
A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.
Herpes Simplex
A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells as a Novel Carrier for Suicide Gene Delivery.
Herpes Simplex
A new method for quantitative determination of tritium-labeled nucleoside kinase products adsorbed on DEAE-cellulose.
Herpes Simplex
A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK).
Herpes Simplex
A New Nucleoside Analogue with Potent Activity against Mutant sr39 Herpes Simplex Virus-1 (HSV-1) Thymidine Kinase (TK).
Herpes Simplex
A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells.
Herpes Simplex
A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs.
Herpes Simplex
A new set of positive/negative selectable markers for mammalian cells.
Herpes Simplex
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
Herpes Simplex
A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment.
Herpes Simplex
A novel 'sort-suicide' fusion gene vector for T cell manipulation.
Herpes Simplex
A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer.
Herpes Simplex
A novel fusion suicide gene yeast CDglyTK plays a role in radio-gene therapy of nasopharyngeal carcinoma.
Herpes Simplex
A novel interferon-gamma regulated human melanoma-associated antigen, gp33-38, defined by monoclonal antibody Me14-D12. II. Molecular cloning of a genomic probe.
Herpes Simplex
A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.
Herpes Simplex
A novel suicide gene therapy system for p53-mutated cells using a wild-type p53-specific promoter and Cre/loxP switch.
Herpes Simplex
A novel suicide gene therapy targeting the overexpression of eukaryotic initiation factor 4E improves survival in a rat peritoneal carcinomatosis model.
Herpes Simplex
A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections.
Herpes Simplex
A novel, codon-optimised HSVtk(A168H) mutant [TK.007] for suicide gene therapy.
Herpes Simplex
A novel, plasmid-based system for studying gene rearrangements in mammalian cells.
Herpes Simplex
A pattern of partially homologous recombination in mouse L cells.
Herpes Simplex
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group.
Herpes Simplex
A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma.
Herpes Simplex
A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients.
Herpes Simplex
A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma.
Herpes Simplex
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma.
Herpes Simplex
A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.
Herpes Simplex
A pilot study of combined suicide/cytokine gene therapy in two patients with end-stage anaplastic thyroid carcinoma.
Herpes Simplex
A Pilot Study of Quality of Life of Patients with Hormone-refractory Prostate Cancer after Gene Therapy.
Herpes Simplex
A pilot study of systemic corticosteroid administration in conjunction with intrapleural adenoviral vector administration in patients with malignant pleural mesothelioma.
Herpes Simplex
A plasmid vehicle suitable for the molecular cloning and characterization of mammalian promoters.
Herpes Simplex
A point mutation in the thymidine kinase gene is responsible for acyclovir-resistance in herpes simplex virus type 2 sequential isolates.
Herpes Simplex
A Positive Selection for Nucleoside Kinases in E. coli.
Herpes Simplex
A potential therapeutic strategy to combat leukemia virus infection.
Herpes Simplex
A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro(R)) after intracerebral administration.
Herpes Simplex
A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging.
Herpes Simplex
A preliminary study on the construction of double suicide gene delivery vectors by mesenchymal stem cells and the in vitro inhibitory effects on SKOV3 cells.
Herpes Simplex
A pseudoreceptor modelling study of the varicella-zoster virus and human thymidine kinase binding sites.
Herpes Simplex
A radioimmunoassay for herpes simplex virus (HSV) thymidine kinase.
Herpes Simplex
A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) thymidine kinase (TK).
Herpes Simplex
A reconstituted telomerase-immortalized human corneal epithelium in vivo: a pilot study.
Herpes Simplex
A replacement vector used to introduce subtle mutations into mouse genes.
Herpes Simplex
A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter.
Herpes Simplex
A role for MAP kinase in the antitumor activity of a nucleoside analog.
Herpes Simplex
A Safety Checkpoint to Eliminate Cancer Risk of the Immune Evasive Cells Derived from Human Embryonic Stem Cells.
Herpes Simplex
A scalable approach to prevent teratoma formation of human embryonic stem cells.
Herpes Simplex
A screen in Escherichia coli for nucleoside analogs that target human immunodeficiency virus (HIV) reverse transcriptase: coexpression of HIV reverse transcriptase and herpes simplex virus thymidine kinase.
Herpes Simplex
A self-inactivating retrovector incorporating the IL-2 promoter for activation-induced transgene expression in genetically engineered T-cells.
Herpes Simplex
A sensitive method for the detection of herpes simplex virus type 2 specific thymidine kinase.
Herpes Simplex
A simple and efficient liposome method for transfection of DNA into mammalian cells grown in suspension.
Herpes Simplex
A simple procedure for expression and purification of selected non-structural (alpha and beta) herpes simplex virus 1 (HSV-1) proteins.
Herpes Simplex
A simple selection system for construction of recombinant gD-negative pseudorabies virus as a vaccine vector.
Herpes Simplex
A simplified one-pot automated synthesis of [18F]FHBG for imaging reporter gene expression.
Herpes Simplex
A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.
Herpes Simplex
A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene.
Herpes Simplex
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.
Herpes Simplex
A spectrophotometric assay for quantitative determination of kcat of herpes simplex virus type 1 thymidine kinase substrates.
Herpes Simplex
A subset of type-specific epitopes map in the amino terminus of herpes simplex virus type 1 glycoprotein B.
Herpes Simplex
A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene.
Herpes Simplex
A tandemly repeated thyroglobulin core promoter has potential to enhance efficacy for tissue-specific gene therapy for thyroid carcinomas.
Herpes Simplex
A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha gene.
Herpes Simplex
A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET.
Herpes Simplex
A transcriptional enhancer essential for the expression of the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene.
Herpes Simplex
A transferred NOE study of a tricyclic analog of acyclovir bound to thymidine kinase.
Herpes Simplex
A Transgenic Rat for Specifically Inhibiting Adult Neurogenesis.
Herpes Simplex
A Tri-fusion Reporter Mouse Reveals Tissue-Specific FGF1B Promoter Activity in vivo.
Herpes Simplex
A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.
Herpes Simplex
A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells.
Herpes Simplex
A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas.
Herpes Simplex
A vehicle for DNA transfer and for recovery of transferred genes: lambda Charon phage-pBR322 hybrid.
Herpes Simplex
A versatile method for the coupling of protein to DNA: synthesis of alpha 2-macroglobulin-DNA conjugates.
Herpes Simplex
A virus-specific thymidine kinase in BHK-21 cells infected with herpes simplex virus.
Herpes Simplex
Aanlysis of dCMP deaminase and CDP reductase levels in hamster cells infected by herpes simplex virus.
Herpes Simplex
Ability of structurally related polycyclic aromatic carcinogens to induce homologous recombination between duplicated chromosomal sequences in mouse L cells.
Herpes Simplex
Ablation of neurogenesis attenuates recovery of motor function after focal cerebral ischemia in middle-aged mice.
Herpes Simplex
Ablation of pituitary pro-opiomelanocortin (POMC) cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model.
Herpes Simplex
Ablation of tumor cells in vivo by direct injection of HSV-thymidine kinase retroviral vector and ganciclovir therapy.
Herpes Simplex
Ablation of tumor-derived stem cells transplanted to the central nervous system by genetic modification of embryonic stem cells with a suicide gene.
Herpes Simplex
Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance.
Herpes Simplex
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma.
Herpes Simplex
Abundant constitutive expression of the immediate-early 94K protein from cytomegalovirus (Colburn) in a DNA-transfected mouse cell line.
Herpes Simplex
Accumulated HSV1-TK Proteins Interfere with Spermatogenesis Through a Disruption of the Integrity of Sertoli-Germ Cell Junctions.
Herpes Simplex
Accumulation of herpes simplex virus type 1 RNAs of different kinetic classes in the cytoplasm of infected cells.
Herpes Simplex
Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells.
Herpes Simplex
Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells.
Herpes Simplex
Activation of a heterologous promoter by human immunodeficiency virus type 1 Tat requires Sp1 and is distinct from the mode of activation by acidic transcriptional activators.
Herpes Simplex
Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA.
Herpes Simplex
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
Herpes Simplex
Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system.
Herpes Simplex
Activation of gene expression via CArG boxes during myogenic differentiation.
Herpes Simplex
Activation of metallothionein expression is potentiated by DNA sequences present in the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone.
Herpes Simplex
Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir.
Herpes Simplex
Activation of the thymidine kinase promoter by herpes simplex virus type 1 immediate early proteins.
Herpes Simplex
Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Herpes Simplex
Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.
Herpes Simplex
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Herpes Simplex
Acute and latent infection by thymidine kinase mutants of herpes simplex virus type 2.
Herpes Simplex
Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.
Herpes Simplex
Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection.
Herpes Simplex
Acyclovir resistance in herpes simplex encephalitis.
Herpes Simplex
Acyclovir resistance in herpes simplex virus type 1: biochemical and functional studies on the thymidine kinase of the highly resistant R100 strain.
Herpes Simplex
Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported.
Herpes Simplex
Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty.
Herpes Simplex
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
Herpes Simplex
Acyclovir-resistant, pathogenic herpesviruses.
Herpes Simplex
Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Addition of a single E2 binding site to the HPV16 E2 long control region enhances killing of HPV-positive cells via HPV E2 protein-regulated HSV-1 thymidine kinase-mediated suicide gene therapy.
Herpes Simplex
Adeno-Associated Virus Liver Transduction Efficiency Measured by in Vivo [(18)F]FHBG Positron Emission Tomography Imaging in Rodents and Nonhuman Primates.
Herpes Simplex
Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intracerebrally implanted human gliomas in mice, in conjunction with ganciclovir administration.
Herpes Simplex
Adenosine- and ADP-phosphorylating capacity of herpes simplex virus-induced thymidine kinase enzyme complex.
Herpes Simplex
Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance.
Herpes Simplex
Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model.
Herpes Simplex
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Herpes Simplex
Adenoviral insulinoma-associated protein 1 promoter-driven suicide gene therapy with enhanced selectivity for treatment of neuroendocrine cancers.
Herpes Simplex
Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo.
Herpes Simplex
Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity.
Herpes Simplex
Adenoviral vectors efficiently target cell lines derived from selected lymphocytic malignancies, including anaplastic large cell lymphoma and Hodgkin's disease.
Herpes Simplex
Adenoviral-delivered HE4-HSV-tk sensitizes ovarian cancer cells to ganciclovir.
Herpes Simplex
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Herpes Simplex
Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir.
Herpes Simplex
Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors.
Herpes Simplex
Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer.
Herpes Simplex
Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies.
Herpes Simplex
Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.
Herpes Simplex
Adenovirus E3-early promoter: sequences required for activation by E1A.
Herpes Simplex
Adenovirus Expressing Both Thymidine Kinase and Soluble PD1 Enhances Antitumor Immunity by Strengthening CD8 T-cell Response.
Herpes Simplex
Adenovirus late sequences linked to herpes simplex virus thymidine kinase may be introduced into eukaryotic cells and transcribed.
Herpes Simplex
Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration.
Herpes Simplex
Adenovirus vector-mediated gene therapy using iodized oil esters for hepatocellular carcinoma in rats.
Herpes Simplex
Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma.
Herpes Simplex
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Herpes Simplex
Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas.
Herpes Simplex
Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.
Herpes Simplex
Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain.
Herpes Simplex
Adenovirus-mediated gene therapy of experimental gliomas.
Herpes Simplex
Adenovirus-mediated gene therapy of gastric carcinoma using cancer-specific gene expression in vivo.
Herpes Simplex
Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression.
Herpes Simplex
Adenovirus-mediated gene therapy of ovarian cancer in a mouse model.
Herpes Simplex
Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a Myc-Max binding motif.
Herpes Simplex
Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing.
Herpes Simplex
Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.
Herpes Simplex
Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.
Herpes Simplex
Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer.
Herpes Simplex
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy combined with ganciclovir induces hepatoma cell apoptosis.
Herpes Simplex
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model.
Herpes Simplex
Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.
Herpes Simplex
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
Herpes Simplex
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
Herpes Simplex
Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.
Herpes Simplex
Adenovirus-mediated suicide gene therapy for experimental bladder cancer.
Herpes Simplex
Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer.
Herpes Simplex
Adenovirus-mediated suicide gene transduction: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits.
Herpes Simplex
Adenovirus-mediated suicide gene transfer to small cell lung carcinoma using a tumor-specific promoter.
Herpes Simplex
Adenovirus-mediated suicide-gene therapy in an orthotopic murine bladder tumor model.
Herpes Simplex
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Herpes Simplex
Adenovirus-mediated targeted gene therapy for breast cancer and for purging hematopoietic stem-cell sources.
Herpes Simplex
Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.
Herpes Simplex
Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up.
Herpes Simplex
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Herpes Simplex
Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery.
Herpes Simplex
Adenovirus-mediated tumor-specific combined gene therapy using Herpes simplex virus thymidine/ganciclovir system and murine interleukin-12 induces effective antitumor activity against medullary thyroid carcinoma.
Herpes Simplex
Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma.
Herpes Simplex
Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases.
Herpes Simplex
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103.
Herpes Simplex
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene.
Herpes Simplex
Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms.
Herpes Simplex
Advances in Imaging Gene-Directed Enzyme Prodrug Therapy.
Herpes Simplex
AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor.
Herpes Simplex
Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction.
Herpes Simplex
Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases alpha and beta.
Herpes Simplex
Allium sativum potentiates suicide gene therapy for murine transitional cell carcinoma.
Herpes Simplex
Allosteric interaction of a herpes simplex viral thymidine kinase with host DNA polymerase alpha in mouse LP1-1 cells.
Herpes Simplex
Alpha interferon and acyclovir treatment of herpes simplex virus in lymphoid cell cultures.
Herpes Simplex
Altered properties of thymidine kinase after infection of mouse fibroblast cells with herpes simplex virus.
Herpes Simplex
Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance.
Herpes Simplex
Amplification of plasmid copy number by thymidine kinase expression in Saccharomyces cerevisiae.
Herpes Simplex
An A/G-rich motif in the rat fibroblast growth factor-2 gene confers enhancer activity on a heterologous promoter in neonatal rat cardiac myocytes.
Herpes Simplex
An adenoviral vector expressing functional heterogeneous proteins herpes simplex viral thymidine kinase and human interleukin-2 has enhanced in vivo antitumor activity against medullary thyroid carcinoma.
Herpes Simplex
An adenovirus vector containing the suicide gene thymidine kinase for a broad application in cancer gene therapy.
Herpes Simplex
An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression.
Herpes Simplex
An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase.
Herpes Simplex
An amplification-promoting sequence from mouse genomic DNA: interaction with a trans-acting factor that also affects gene expression.
Herpes Simplex
An approach to the cloning of cell surface protein genes. Selection by cell sorting of mouse L-cells that express HLA or 4F2 antigens after transformation with total human DNA.
Herpes Simplex
An armed, YB-1-dependent oncolytic adenovirus as a candidate for a combinatorial anti-glioma approach of virotherapy, suicide gene therapy and chemotherapeutic treatment.
Herpes Simplex
An autologous in situ tumor vaccination approach for hepatocellular carcinoma. 1. Flt3 ligand gene transfer increases antitumor effects of a radio-inducible suicide gene therapy in an ectopic tumor model.
Herpes Simplex
An efficient expression vector for stable expression in human liver cells.
Herpes Simplex
An efficient procedure to select and recover recombinant adenovirus vectors.
Herpes Simplex
An Efficient Strategy for Obtaining Mutants by Targeted Gene Deletion in Ophiostoma novo-ulmi.
Herpes Simplex
An enhancer in the first intron of the human purine nucleoside phosphorylase-encoding gene.
Herpes Simplex
An experimental application of gene therapy for human retinoblastoma.
Herpes Simplex
An expression vector inhibits gene expression in Xenopus embryos by antisense RNA.
Herpes Simplex
An HSVtk-mediated local and distant antitumor bystander effect in tumors of head and neck origin in athymic mice.
Herpes Simplex
An improved retroviral vector encoding the herpes simplex virus thymidine kinase gene increases antitumor efficacy in vivo.
Herpes Simplex
An Improved Single-Step Cloning Strategy Simplifies the Agrobacterium tumefaciens-Mediated Transformation (ATMT)-Based Gene-Disruption Method for Verticillium dahliae.
Herpes Simplex
An improved strategy for the synthesis of [(18)F]-labeled arabinofuranosyl nucleosides.
Herpes Simplex
An in vitro nucleoside analog screening method for cancer gene therapy.
Herpes Simplex
An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression.
Herpes Simplex
An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice.
Herpes Simplex
An optimized thymidylate kinase assay, based on enzymatically synthesized 5-[125I]iododeoxyuridine monophosphate and its application to an immunological study of herpes simplex virus thymidine-thymidylate kinases.
Herpes Simplex
An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.
Herpes Simplex
An S1 nuclease-sensitive region in the first intron of human platelet-derived growth factor A-chain gene contains a negatively acting cell type-specific regulatory element.
Herpes Simplex
An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene.
Herpes Simplex
An upstream region of the rat luteinizing hormone beta gene binds estrogen receptor and confers estrogen responsiveness.
Herpes Simplex
Analysis in Cos-1 cells of processing and polyadenylation signals by using derivatives of the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.
Herpes Simplex
Analysis of nucleotide sequence variations in herpes simplex virus types 1 and 2, and varicella-zoster virus.
Herpes Simplex
Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymes.
Herpes Simplex
Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies.
Herpes Simplex
Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2.
Herpes Simplex
Analysis of the role of the cysteine 171 residue in the activity of herpes simplex virus type 1 thymidine kinase by oligonucleotide-directed mutagenesis.
Herpes Simplex
Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses.
Herpes Simplex
Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Herpes Simplex
Analysis of the TK enzyme complex induced by HSV types 1 and 2 by means of isoelectric focusing and polyacrylamide gel electrophoresis.
Herpes Simplex
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation.
Herpes Simplex
Angiogenic gene cell therapy using suicide gene system regulates the effect of angiogenesis in infarcted rat heart.
Herpes Simplex
Antagonism of HSV-tk transfection and ganciclovir treatment on chemotherapeutic drug sensitivity.
Herpes Simplex
Anti-angiogenic gene therapy for hepatocellular carcinoma mediated by microbubble-enhanced ultrasound exposure: an in vivo experimental study.
Herpes Simplex
Anti-tumor effects of engineered mesenchymal stem cells in colon cancer model.
Herpes Simplex
Anti-tumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras(G12V).
Herpes Simplex
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.
Herpes Simplex
Antiherpetic activity and mechanism of action of 9-(4-hydroxybutyl)guanine.
Herpes Simplex
Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion.
Herpes Simplex
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Herpes Simplex
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Herpes Simplex
Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models.
Herpes Simplex
Antitumor effect of secreted Flt3-ligand can act at distant tumor sites in a murine model of head and neck cancer.
Herpes Simplex
Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation.
Herpes Simplex
Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth.
Herpes Simplex
Antitumor effects on human melanoma xenografts of an amplicon vector transducing the herpes thymidine kinase gene followed by ganciclovir.
Herpes Simplex
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
Herpes Simplex
Antiviral activity of the marine alga Symphyocladia latiuscula against herpes simplex virus (HSV-1) in vitro and its therapeutic efficacy against HSV-1 infection in mice.
Herpes Simplex
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Herpes Simplex
Apoptosis of the thick ascending limb results in acute kidney injury.
Herpes Simplex
Apoptosis-mediated regulation of recombinant human granulocyte colony-stimulating factor production by genetically engineered fibroblasts.
Herpes Simplex
Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells.
Herpes Simplex
Application of next-generation sequencing to detect acyclovir-resistant herpes simplex virus type 1 variants at low frequency in thymidine kinase gene of the isolates recovered from patients with hematopoietic stem cell transplantation.
Herpes Simplex
Application of the Cre recombinase/loxP system further enhances antitumor effects in cell type-specific gene therapy against carcinoembryonic antigen-producing cancer.
Herpes Simplex
Applying the herpes simplex virus thymidine kinase/ganciclovir approach to ovarian cancer: an effective in vitro drug-sensitization system.
Herpes Simplex
Arabinose furanosyl thymidine: uptake, phosphorylation and incorporation into DNA of mammalian cells.
Herpes Simplex
Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene.
Herpes Simplex
Assays for noninvasive imaging of reporter gene expression.
Herpes Simplex
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations.
Herpes Simplex
Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.
Herpes Simplex
Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy.
Herpes Simplex
Assessment of the long-term transcriptional activity of a 550-bp-long human ?-actin promoter region.
Herpes Simplex
Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy.
Herpes Simplex
Assessment of treatment response by autoradiography with (14)C-aminocyclopentane carboxylic acid, (67)Ga-DTPA, and (18)F-FDG in a herpes simplex virus thymidine kinase/ganciclovir brain tumor model.
Herpes Simplex
Association of herpes simplex thymidine kinase gene with chromosome No. 18 in transformed human cells.
Herpes Simplex
Association of the herpes simplex-1 viral gene for thymidine kinase with the human gene for adenylate kinase-1 in biochemically transformed cells.
Herpes Simplex
Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus.
Herpes Simplex
Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells.
Herpes Simplex
Augmentation of gamma-globin gene promoter activity by carboxylic acids and components of the human beta-globin locus control region.
Herpes Simplex
Autonomous replicating sequences from mouse cells which can replicate in mouse cells in vivo and in vitro.
Herpes Simplex
Autopsy neuropathological findings in 'burnt out' herpes simplex encephalitis and use of the polymerase chain reaction to detect viral DNA.
Herpes Simplex
AV.TK-mediated killing of subcutaneous tumors in situ results in effective immunization against established secondary intracranial tumor deposits.
Herpes Simplex
Avian adenovirus vector CELO-TK displays anticancer activity in human cancer cells and suppresses established murine melanoma tumors.
Herpes Simplex
Avian retrovirus integrase-enhanced transgene integration into mammalian cell DNA in vivo.
Herpes Simplex
Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy.
Herpes Simplex
Azidodeoxythymidine and didehydrodeoxythymidine as inhibitors and substrates of the human herpesvirus 8 thymidine kinase.
Herpes Simplex
B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.
Herpes Simplex
Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy.
Herpes Simplex
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.
Herpes Simplex
Basic peptide system for efficient delivery of foreign genes.
Herpes Simplex
BCR-ABL-expressing cells transduced with the HSV-tk gene die by apoptosis upon treatment with ganciclovir.
Herpes Simplex
Beta-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse.
Herpes Simplex
Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer.
Herpes Simplex
Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs.
Herpes Simplex
Biochemical and immunological characterization of deoxythymidine kinase of thymidine kinaseless HeLa cells biochemically transformed by herpes simplex virus type.
Herpes Simplex
Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells.
Herpes Simplex
Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity.
Herpes Simplex
Biochemical classification of herpes simplex virus types 1 and 2, and of intermediate strains on the basis of different susceptibilities of thymidine kinase to thymidine analogues.
Herpes Simplex
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor.
Herpes Simplex
Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1.
Herpes Simplex
Biochemical transformation of LM(TK-) cells by hybrid plasmids containing the coding region of the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Biochemical transformation of thymidine kinase (TK)-deficient mouse cells by herpes simplex virus type 1 DNA fragments purified from hybrid plasmids.
Herpes Simplex
Biodistribution, PET, and radiation dosimetry estimates of HSV-tk gene expression imaging agent 1-(2'-Deoxy-2'-18F-Fluoro-beta-D-arabinofuranosyl)-5-iodouracil in normal dogs.
Herpes Simplex
Biology of simian virus 40 (SV40) transplantation antigen (TrAg). IX. Analysis of TrAg in mouse cells synthesizing truncated SV40 large T antigen.
Herpes Simplex
Biomimetic cell membrane-coated DNA nanoparticles for gene delivery to glioblastoma.
Herpes Simplex
Biophysical characterization of vaccinia virus thymidine kinase substrate utilization.
Herpes Simplex
BK virus-plasmid expression vector that persists episomally in human cells and shuttles into Escherichia coli.
Herpes Simplex
Bluetongue Virus Particles as Nanoreactors for Enzyme Delivery and Cancer Therapy.
Herpes Simplex
Bone metastasis imaging with SPECT/CT/MRI: A preclinical toolbox for therapy studies.
Herpes Simplex
Both early and late control sequences of SV40 and polyoma promote transcription of Escherichia coli gpt gene in transfected cells.
Herpes Simplex
Both soluble and membrane-bound forms of Flt3 ligand enhance tumor immunity following "suicide" gene therapy in a murine colon carcinoma model.
Herpes Simplex
Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit.
Herpes Simplex
Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging.
Herpes Simplex
Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.
Herpes Simplex
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Herpes Simplex
Bromodeoxyuridine labeling and flow cytometric identification of replicating Saccharomyces cerevisiae cells: lengths of cell cycle phases and population variability at specific cell cycle positions.
Herpes Simplex
Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy.
Herpes Simplex
Building a metal-responsive promoter with synthetic regulatory elements.
Herpes Simplex
Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma.
Herpes Simplex
Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43.
Herpes Simplex
Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication.
Herpes Simplex
Bystander effect in suicide gene therapy using immortalized neural stem cells transduced with herpes simplex virus thymidine kinase gene on medulloblastoma regression.
Herpes Simplex
Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues.
Herpes Simplex
Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cells.
Herpes Simplex
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.
Herpes Simplex
Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.
Herpes Simplex
Bystander Killing of Malignant Glioma by Bone Marrow-derived Tumor-Infiltrating Progenitor Cells Expressing a Suicide Gene.
Herpes Simplex
Bystander or no bystander for gene directed enzyme prodrug therapy.
Herpes Simplex
Bystander-mediated regression of murine neuroblastoma via retroviral transfer of the HSV-TK gene.
Herpes Simplex
Bystander-mediated regression of osteosarcoma via retroviral transfer of the herpes simplex virus thymidine kinase and human interleukin-2 genes.
Herpes Simplex
BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.
Herpes Simplex
C-5 hydroxyethyl and hydroxypropyl acyclonucleosides as substrates for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK): syntheses and biological evaluation.
Herpes Simplex
cAMP stimulates the bystander effect in suicide gene therapy of human choriocarcinoma.
Herpes Simplex
Cancer Cell Targeting with Mouse TERT-Specific Group I Intron of Tetrahymena thermophila.
Herpes Simplex
Cancer chemotherapy using suicide genes.
Herpes Simplex
Cancer gene therapy and immunotherapy (review).
Herpes Simplex
Cancer gene therapy by direct tumor injections of a nonviral T7 vector encoding a thymidine kinase gene.
Herpes Simplex
Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo.
Herpes Simplex
Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect.
Herpes Simplex
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme.
Herpes Simplex
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.
Herpes Simplex
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Herpes Simplex
Canine T cells transduced with a herpes simplex virus thymidine kinase gene: a model to study effects on engraftment and control of graft-versus-host disease.
Herpes Simplex
Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
Herpes Simplex
Carbocyclic analogues of 5-halocytosine nucleosides.
Herpes Simplex
Carcinogens can induce homologous recombination between duplicated chromosomal sequences in mouse L cells.
Herpes Simplex
Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models.
Herpes Simplex
Cationic liposomes enhance retrovirus-mediated multinucleated cell formation and retroviral transduction.
Herpes Simplex
CC Ar GG boxes, cis-acting elements with a dual specificity. Muscle-specific transcriptional activation and serum responsiveness.
Herpes Simplex
CCAAT/enhancer-binding protein beta (C/EBP beta) binds and activates while hepatocyte nuclear factor-4 (HNF-4) does not bind but represses the liver-type arginase promoter.
Herpes Simplex
CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma.
Herpes Simplex
Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells.
Herpes Simplex
Cell death associated with genetic prodrug activation therapy of colorectal cancer.
Herpes Simplex
Cell death induced by the herpes simplex virus-1 thymidine kinase delivered by human immunodeficiency virus-1-based virus-like particles.
Herpes Simplex
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Herpes Simplex
Cell-based interferon gene therapy using proliferation-controllable, interferon-releasing mesenchymal stem cells.
Herpes Simplex
Cell-cycle regulatory sequences in a hamster histone promoter and their interactions with cellular factors.
Herpes Simplex
Cell-free synthesis of herpes simplex virus-coded pyrimidine deoxyribonucleoside kinase enzyme.
Herpes Simplex
Cell-specific cytotoxicity of human pancreatic adenocarcinoma cells using rat insulin promoter thymidine kinase-directed gene therapy.
Herpes Simplex
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Herpes Simplex
Cell-specific selection of mutants of a herpes simplex virus recombinant carrying deletions.
Herpes Simplex
Cell-specific targeting of a thymidine kinase/ganciclovir gene therapy system using a recombinant Sindbis virus vector.
Herpes Simplex
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein.
Herpes Simplex
Cells producing recombinant retrovirus with thymidine kinase gene from Herpes simplex virus suitable for human cancer gene therapy.
Herpes Simplex
Cellular engineering of HSV-tk transduced, expanded T lymphocytes for graft-versus-host disease management.
Herpes Simplex
Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts.
Herpes Simplex
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Herpes Simplex
Changes of tumor vascularity during gene therapy monitored with color Doppler US.
Herpes Simplex
Characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons.
Herpes Simplex
Characterization of a novel liver-specific enhancer in the human prothrombin gene.
Herpes Simplex
Characterization of a silencer element and purification of a silencer protein that negatively regulates the human adenine nucleotide translocator 2 promoter.
Herpes Simplex
Characterization of an estrogen-responsive element implicated in regulation of the rainbow trout estrogen receptor gene.
Herpes Simplex
Characterization of DNA-protein complex formation in nuclear extracts with a sequence from the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Characterization of eukaryotic transcriptional control signals by assay of herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.
Herpes Simplex
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.
Herpes Simplex
Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir.
Herpes Simplex
Characterization of HIV-1 TAT peptide as an enhancer of HSV-TK/GCV cancer gene therapy.
Herpes Simplex
Characterization of iRGD-Ligand Modified Arginine-Histidine-Rich Peptides for Nucleic Acid Therapeutics Delivery to ?v?3 Integrin-Expressing Cancer Cells.
Herpes Simplex
Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Characterization of mutants of herpes simplex viruses, types 1 and 2, that produce fragments of the thymidine kinase polypeptide.
Herpes Simplex
Characterization of placental transcriptional activation of the human gene for P450scc.
Herpes Simplex
Characterization of pyrimidine deoxyribonucleoside kinase (thymidine kinase) and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 and in cells infected with mutant strains of herpes simplex virus.
Herpes Simplex
Characterization of RNA polymerase II-dependent transcription in Xenopus extracts.
Herpes Simplex
Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1.
Herpes Simplex
Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers.
Herpes Simplex
Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed.
Herpes Simplex
Characterization of the hepatitis B virus EnhI enhancer and X promoter complex.
Herpes Simplex
Characterization of the human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) oncogene, kaposin (ORF K12).
Herpes Simplex
Characterization of the mRNA for herpes simplex virus thymidine kinase by cell-free synthesis of active enzyme.
Herpes Simplex
Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.
Herpes Simplex
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Herpes Simplex
Characterization of tissue-specific transcription by the human synapsin I gene promoter.
Herpes Simplex
Chemically induced mutagenesis in a shuttle vector with a low-background mutant frequency.
Herpes Simplex
Chicken ovalbumin gene fused to a herpes simplex virus alpha promoter and linked to a thymidine kinase gene is regulated like a viral gene.
Herpes Simplex
Cholangiocarcinoma: molecular imaging-guided radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus thymidine kinase gene therapy.
Herpes Simplex
Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.
Herpes Simplex
Chromosomal aberrations induced by double strand DNA breaks.
Herpes Simplex
Chromosomal site(s) of integration of Herpes simplex virus type 2 thymidine kinase gene in biochemically transformed human cells.
Herpes Simplex
Chromosome healing in mouse embryonic stem cells.
Herpes Simplex
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
Herpes Simplex
Circumventing recombination events encountered with production of a clinical-grade adenoviral vector with a double-expression cassette.
Herpes Simplex
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Herpes Simplex
Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion.
Herpes Simplex
Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.
Herpes Simplex
Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.
Herpes Simplex
Clinical protocol. Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme.
Herpes Simplex
Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor.
Herpes Simplex
Clonal analysis of early and late stages of erythroleukemia induced by molecular clones of integrated spleen focus-forming virus.
Herpes Simplex
Cloned mouse mammary tumor virus DNA is biologically active in transfected mouse cells and its expression is stimulated by glucocorticoid hormones.
Herpes Simplex
Cloning and characterization of a retroviral plasmid, pCC1, for combination suicide gene therapy.
Herpes Simplex
Cloning and expression of human deoxyguanosine kinase cDNA.
Herpes Simplex
Cloning and expression of the thyrotropin-releasing hormone receptor from GH3 rat anterior pituitary cells.
Herpes Simplex
Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in K-12.
Herpes Simplex
Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12.
Herpes Simplex
Cloning of the herpes simplex virus type 1 thymidine kinase gene in E. coli K 12: a selective marker for gene transfer into animal cells.
Herpes Simplex
Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements.
Herpes Simplex
Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects.
Herpes Simplex
Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene.
Herpes Simplex
Co-packaging of non-vector RNAs generates replication-defective retroviral vector particles: a novel approach for blocking retrovirus replication.
Herpes Simplex
Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth.
Herpes Simplex
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM.
Herpes Simplex
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Herpes Simplex
Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells
Herpes Simplex
Coexpression of the partial androgen receptor enhances the efficacy of prostate-specific antigen promoter-driven suicide gene therapy for prostate cancer cells at low testosterone concentrations.
Herpes Simplex
Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine.
Herpes Simplex
Coexpression of the Uracil Phosphoribosyltransferase Gene with a Chimeric Human Nerve Growth Factor Receptor/Cytosine Deaminase Fusion Gene, Using a Single Retroviral Vector, Augments Cytotoxicity of Transduced Human T Cells Exposed to 5-Fluorocytosine.
Herpes Simplex
Combination effect of oncolytic adenovirus therapy and herpes simplex virus thymidine kinase/ganciclovir in hepatic carcinoma animal models.
Herpes Simplex
Combination electro-gene therapy using herpes virus thymidine kinase and interleukin-12 expression plasmids is highly efficient against murine carcinomas in vivo.
Herpes Simplex
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase.
Herpes Simplex
Combination gene therapy for liver metastasis of colon carcinoma in vivo.
Herpes Simplex
Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase.
Herpes Simplex
Combination of pet imaging with viral vectors for identification of cancer metastases.
Herpes Simplex
Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival.
Herpes Simplex
Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer.
Herpes Simplex
Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy.
Herpes Simplex
Combinatorial targeting of 2 different steps in adenoviral DNA replication by herpes simplex virus thymidine kinase and artificial microRNA expression for the inhibition of virus multiplication in the presence of ganciclovir.
Herpes Simplex
Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide gene.
Herpes Simplex
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Herpes Simplex
Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma.
Herpes Simplex
Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma.
Herpes Simplex
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Herpes Simplex
Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity.
Herpes Simplex
Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes.
Herpes Simplex
Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir.
Herpes Simplex
Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells.
Herpes Simplex
Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes.
Herpes Simplex
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Herpes Simplex
Comparative genomic analysis of the HNF-4alpha transcription factor gene.
Herpes Simplex
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Herpes Simplex
Comparative study of the genetic variability in thymidine kinase and glycoprotein B genes of herpes simplex viruses by the RNase A mismatch cleavage method.
Herpes Simplex
Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.
Herpes Simplex
Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.
Herpes Simplex
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Herpes Simplex
Comparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs.
Herpes Simplex
Comparison of intron-dependent and intron-independent gene expression.
Herpes Simplex
Comparison of polymorphism of thymidine kinase gene and restriction fragment length polymorphism of genomic DNA in herpes simplex virus type 1.
Herpes Simplex
Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression.
Herpes Simplex
Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches.
Herpes Simplex
Comparison of the in vitro and in vivo antiherpes virus activities of the acyclic nucleosides, acyclovir (Zovirax) and 9-[(2-hydroxy-1-hydroxymethylethoxy)methyl]guanine (BWB759U).
Herpes Simplex
Comparison of the transcriptional properties of the Friend and Moloney retrovirus long terminal repeats: importance of tandem duplications and of the core enhancer sequence.
Herpes Simplex
Comparison of thymidine kinase activities indiced in cells productively infected with herpesvirus saimiri and herpes simplex virus.
Herpes Simplex
Comparison of two methods in the determination of the sensitivity of 84 herpes simplex virus (HSV) type 1 and 2 clinical isolates to acyclovir and alpha-interferon.
Herpes Simplex
Comparison of [(14)C]FMAU, [(3)H]FEAU, [(14)C]FIAU, and [(3)H]PCV for Monitoring Reporter Gene Expression of Wild Type and Mutant Herpes Simplex Virus Type 1 Thymidine Kinase in Cell Culture.
Herpes Simplex
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Herpes Simplex
Competition and complementation between thymidine kinase-negative and wild-type herpes simplex virus during co-infection of mouse trigeminal ganglia.
Herpes Simplex
Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2.
Herpes Simplex
Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Complete regression of metastatic de-differentiated liposarcoma with engineered mesenchymal stromal cells with dTRAIL and HSV-TK.
Herpes Simplex
Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study.
Herpes Simplex
Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein.
Herpes Simplex
Computer-aided active-site-directed modeling of the herpes simplex virus 1 and human thymidine kinase.
Herpes Simplex
Conditional ablation and recovery of forebrain neurogenesis in the mouse.
Herpes Simplex
Conditional ablation of dendritic cells in transgenic mice.
Herpes Simplex
Conditional ablation of neurones in transgenic mice.
Herpes Simplex
Conditional cell suicide using dox-dependent caspase-2 expression.
Herpes Simplex
Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells.
Herpes Simplex
Conditional Cytotoxic Anti-HIV Gene Therapy for Selectable Cell Modification.
Herpes Simplex
Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice.
Herpes Simplex
Conditional expression of a suicide gene by the telomere reverse transcriptase promoter for potential post-therapeutic deletion of tumorigenesis.
Herpes Simplex
Conditional reduction of human immunodeficiency virus type 1 replication by a gain-of-herpes simplex virus 1 thymidine kinase function.
Herpes Simplex
Conditionally replicating adenovirus SG500-expressed mutant Dm-dNK gene for breast cancer therapy.
Herpes Simplex
Configurations of a two-tiered amplified gene expression system in adenoviral vectors designed to improve the specificity of in vivo prostate cancer imaging.
Herpes Simplex
Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma.
Herpes Simplex
Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV.
Herpes Simplex
Connexin 43-enhanced suicide gene therapy using herpesviral vectors.
Herpes Simplex
Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing colon cell line.
Herpes Simplex
Connexin32?mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity.
Herpes Simplex
Connexins are expressed in primary brain tumors and enhance the bystander effect in gene therapy.
Herpes Simplex
Consequences of thyroid hormone deficiency induced by the specific ablation of thyroid follicle cells in adult transgenic mice.
Herpes Simplex
Conservative intrachromosomal recombination between inverted repeats in mouse cells: association between reciprocal exchange and gene conversion.
Herpes Simplex
Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities.
Herpes Simplex
Conserved sequences near the early transcription start sites of vaccinia virus.
Herpes Simplex
Construction and characterization of a recombinant plasmid encoding the gene for the thymidine kinase of Herpes simplex type 1 virus.
Herpes Simplex
Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences.
Herpes Simplex
Construction and characterization of a stably transformed HeLa cell line in which the expression of bovine herpesvirus 1 ICP0 (BICP0) is induced by tetracycline.
Herpes Simplex
Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.
Herpes Simplex
Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1.
Herpes Simplex
Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects.
Herpes Simplex
Construction of a differentiated human hepatocyte cell line expressing the herpes simplex virus-thymidine kinase gene.
Herpes Simplex
Construction of a dominant selective marker useful for gene transfer studies in animal cells.
Herpes Simplex
Construction of a ganciclovir-sensitive lentiviral vector to assess the influence of angiopoietin-3 and soluble Tie2 on glioma growth.
Herpes Simplex
Construction of a herpes simplex virus/varicella-zoster virus (HSV/VZV) thymidine kinase recombinant with the pathogenic potential of HSV and a drug sensitivity profile resembling that of VZV.
Herpes Simplex
Construction of a mammalian transducing vector from the genome of Moloney murine leukemia virus.
Herpes Simplex
Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen.
Herpes Simplex
Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway.
Herpes Simplex
Construction of gene therapy vectors targeting thyroid cells: enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the cyclic adenosine 3',5'-monophosphate pathway and demonstration of activity in follicular and anaplastic thyroid carcinoma cells.
Herpes Simplex
Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice.
Herpes Simplex
Construction of plasmid vector pAFP-HSVtk-IRES2-EGFP and its effect on the cytotoxicity of ganciclovir to hepatocellular carcinoma.
Herpes Simplex
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.
Herpes Simplex
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. 1982.
Herpes Simplex
Construction of rat cell lines that contain potential morphologically transforming regions of the herpes simplex virus type 2 genome.
Herpes Simplex
Construction of strains for rapid homokaryon purification after integration of constructs at the histidine-3 ( his-3) locus of Neurospora crassa.
Herpes Simplex
Contribution of a combination of ponicidin and acyclovir/ganciclovir to the antitumor efficacy of the herpes simplex virus thymidine kinase gene therapy system.
Herpes Simplex
Control of expression of the herpes simplex virus thymidine kinase gene in biochemically transformed cells.
Herpes Simplex
Control of Herpes simplex virus thymidine kinase gene expression in Saccharomyces cerevisiae by a yeast promoter sequence.
Herpes Simplex
Control of the expression of a herpes simplex virus thymidine kinase gene incorporated into thymidine kinase-deficient mouse cells.
Herpes Simplex
Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.
Herpes Simplex
Cooperation between CCAAT and octamer motifs in the distal sequence element of the rat U3 small nucleolar RNA promoter.
Herpes Simplex
Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.
Herpes Simplex
Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer.
Herpes Simplex
Cooperative therapeutic effects of herpes simplex virus thymidine kinase gene/ganciclovir system and chemotherapeutic agents on prostate cancer in vitro.
Herpes Simplex
Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure.
Herpes Simplex
Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells.
Herpes Simplex
Correlation of glucocorticoid receptor binding sites on MMTV proviral DNA with hormone inducible transcription.
Herpes Simplex
Correlation of the virus sequence content and biological properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene.
Herpes Simplex
Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells.
Herpes Simplex
Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells.
Herpes Simplex
Cre/loxP system controlled by specific promoter for radiation-mediated gene therapy of hepatoma.
Herpes Simplex
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.
Herpes Simplex
CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes.
Herpes Simplex
CRISPR/Cas9-Mediated Knockin Application in Cell Therapy: A Non-viral Procedure for Bystander Treatment of Glioma in Mice.
Herpes Simplex
Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.
Herpes Simplex
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Herpes Simplex
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Herpes Simplex
Curcumin plays a synergistic role in combination with HSV-TK/GCV in inhibiting growth of murine B16 melanoma cells and melanoma xenografts.
Herpes Simplex
Cure of mice with established metastatic friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-alpha 1 and herpes simplex thymidine kinase followed by ganciclovir.
Herpes Simplex
Current progress in suicide gene therapy for cancer.
Herpes Simplex
Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells.
Herpes Simplex
Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir.
Herpes Simplex
Cytopathogenicity, drug susceptibility, and thymidine kinase activity of a retinovirulent herpes simplex virus type 2.
Herpes Simplex
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy.
Herpes Simplex
Cytosine methylation in CTF and Sp1 recognition sites of an HSV tk promoter: effects on transcription in vivo and on factor binding in vitro.
Herpes Simplex
Cytotoxic effect of acyclovir on cultured mammalian cells to which herpesvirus thymidine kinase gene was introduced.
Herpes Simplex
Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells.
Herpes Simplex
Cytotoxicity and antiangiogenesis by fibroblast growth factor 2-targeted Ad-TK cancer gene therapy.
Herpes Simplex
Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.
Herpes Simplex
D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
Herpes Simplex
Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.
Herpes Simplex
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.
Herpes Simplex
Death and Proliferation Time Course of Stem Cells Transplanted in the Myocardium.
Herpes Simplex
Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.
Herpes Simplex
Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma.
Herpes Simplex
Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii.
Herpes Simplex
Delayed morbidity and mortality of albumin/SV40 T-antigen transgenic mice after insertion of an alpha-fetoprotein/herpes virus thymidine kinase transgene and treatment with ganciclovir.
Herpes Simplex
Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft.
Herpes Simplex
Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression.
Herpes Simplex
Delivery of herpes simplex thymidine kinase bystander effect by engineered human mesothelial cells for the treatment of ovarian cancer.
Herpes Simplex
Demethylation and expression of methylated plasmid DNA stably transfected into HeLa cells.
Herpes Simplex
Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics.
Herpes Simplex
Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.
Herpes Simplex
Density functional studies on herpes simplex virus type 1 thymidine kinase-substrate interactions: the role of Tyr-172 and Met-128 in thymine fixation.
Herpes Simplex
Deoxypyrimidine kinases of herpes simplex viruses types 1 and 2: comparison of serological and structural properties.
Herpes Simplex
Deoxyribonuclease I sensitivity of plasmid genomes in teratocarcinoma-derived stem and differentiated cells.
Herpes Simplex
Deoxyribonucleic acid-mediated gene transfer in mammalian cells: molecular analysis of unstable transformants and their progression to stability.
Herpes Simplex
Deoxyribonucleoside triphosphate pools in herpes simplex type 1 infected cells.
Herpes Simplex
Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology.
Herpes Simplex
Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice.
Herpes Simplex
Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice.
Herpes Simplex
Derivation of a triple mosaic adenovirus for cancer gene therapy.
Herpes Simplex
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
Herpes Simplex
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
Herpes Simplex
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
Herpes Simplex
Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.
Herpes Simplex
Detection of an IE responsive element(s) in the BamHI J fragment of human cytomegalovirus AD169.
Herpes Simplex
Detection of exogenous gene sequences in dissolved DNA from aquatic environments.
Herpes Simplex
Detection of herpes simplex virus DNA sequences in corneal transplant recipients by polymerase chain reaction assays.
Herpes Simplex
Detection of herpes simplex virus thymidine kinase and latency-associated transcript gene sequences in human herpetic corneas by polymerase chain reaction amplification.
Herpes Simplex
Detection of herpes simplex virus thymidine kinase polypeptides in cells labeled with 35S-methionine.
Herpes Simplex
Detection of immediate early protein ICP27/IE63 and thymidine kinase in the course of reactivation of latent herpes simplex virus 1 infection.
Herpes Simplex
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate.
Herpes Simplex
Detection of mutations within the thymidine kinase gene of herpes simplex virus type 1 by denaturing gradient gel electrophoresis.
Herpes Simplex
Detection of viral DNA in neonatal herpes encephalitis autopsy tissues by solution-phase PCR: comparison with pathology and immunohistochemistry.
Herpes Simplex
Determination of mRNA fate by different RNA polymerase II promoters.
Herpes Simplex
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Herpes Simplex
Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene.
Herpes Simplex
Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions.
Herpes Simplex
Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors.
Herpes Simplex
Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.
Herpes Simplex
Development of a competitive PCR method for in vitro and in vivo quantification of herpes simplex virus thymidine kinase and neomycin resistance-expressing cells used in a clinical trial.
Herpes Simplex
Development of a Conditionally Replicating Pseudorabies Virus for HER-2/neu-overexpressing Bladder Cancer Therapy.
Herpes Simplex
Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Development of a positive-negative selection procedure for gene targeting in fish cells.
Herpes Simplex
Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes.
Herpes Simplex
Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.
Herpes Simplex
Development of anti-tumor immunity against a non-immunogenic mammary carcinoma through in vivo somatic GM-CSF, IL-2, and HSVtk combination gene therapy.
Herpes Simplex
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.
Herpes Simplex
Development of gene therapy using prostate-specific membrane antigen promoter/enhancer with Cre Recombinase/LoxP system for prostate cancer cells under androgen ablation condition.
Herpes Simplex
Development of genetically modified eliminable human dermal fibroblast feeder cells for ocular surface regeneration medicine.
Herpes Simplex
Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.
Herpes Simplex
Development of novel cationic liposomes for efficient gene transfer into peritoneal disseminated tumor.
Herpes Simplex
Development of novel selective cell ablation in the mammary gland and brain to study cell-cell interactions and chemoprevention.
Herpes Simplex
Development of synthetic promoters for radiation-mediated gene therapy.
Herpes Simplex
Development of Systemic Immunologic Responses Against Hepatic Metastases During Gene Therapy for Peritoneal Carcinomatosis With Retroviral HS-tk and Ganciclovir.
Herpes Simplex
Developments in suicide genes for preclinical and clinical applications.
Herpes Simplex
Diagnosis of herpes encephalitis via Southern blotting of cerebrospinal fluid DNA amplified by polymerase chain reaction.
Herpes Simplex
Diagnostic imaging of herpes simplex virus encephalitis using a radiolabeled antiviral drug: autoradiographic assessment in an animal model.
Herpes Simplex
Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus.
Herpes Simplex
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Herpes Simplex
Different transmission rates of herpesvirus thymidine kinase reporter transgenes from founder male parents and male parents of subsequent generations.
Herpes Simplex
Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer.
Herpes Simplex
Differential effects of base-pair mismatch on intrachromosomal versus extrachromosomal recombination in mouse cells.
Herpes Simplex
Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase.
Herpes Simplex
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Herpes Simplex
Differential metabolism of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by equine herpesvirus type 1- and herpes simplex virus-infected cells.
Herpes Simplex
Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir.
Herpes Simplex
Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy.
Herpes Simplex
Differential susceptibility of human neural cell types in culture to infection with herpes simplex virus.
Herpes Simplex
Differential transcriptional regulation by the alpha- and gamma-catalytic subunit isoforms of cAMP-dependent protein kinase.
Herpes Simplex
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Herpes Simplex
Differential transient and long-term expression of DNA sequences introduced into T-lymphocyte lines.
Herpes Simplex
Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes.
Herpes Simplex
Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors.
Herpes Simplex
Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase.
Herpes Simplex
Direct intratumoral gene transfer of the herpes simplex virus thymidine kinase gene with DNA-liposome complexes: growth inhibition of tumors and lack of localization in normal tissues.
Herpes Simplex
Direct-repeat analysis of chromatid interactions during intrachromosomal recombination in mouse cells.
Herpes Simplex
Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo.
Herpes Simplex
Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling.
Herpes Simplex
Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene.
Herpes Simplex
Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element.
Herpes Simplex
Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors.
Herpes Simplex
Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis.
Herpes Simplex
Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.
Herpes Simplex
Distribution, persistency, toxicity, and lack of replication of an E1A-deficient adenoviral vector after intracardiac delivery in the cotton rat.
Herpes Simplex
Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids.
Herpes Simplex
Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia.
Herpes Simplex
DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells.
Herpes Simplex
DNA length is a critical parameter for eukaryotic transcription in vivo.
Herpes Simplex
DNA methylation and the regulation of globin gene expression.
Herpes Simplex
DNA methylation directs a time-dependent repression of transcription initiation.
Herpes Simplex
DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.
Herpes Simplex
DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions.
Herpes Simplex
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
Herpes Simplex
DNA sequence responsible for the amplification of adjacent genes.
Herpes Simplex
DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.
Herpes Simplex
DNA sequences downstream from the vitamin D response element of the rat osteocalcin gene are required for ligand-dependent transactivation.
Herpes Simplex
DNA sequences required for transcription in vivo of the human corticotropin-beta-lipotropin precursor gene.
Herpes Simplex
DNA-liposome complexes transduction of herpes simplex virus thymidine kinase renders human tongue cancer cell line sensitive to ganciclovir in vitro.
Herpes Simplex
DNA-mediated gene transfer efficiency is enhanced by ionizing and ultraviolet irradiation of rodent cells in vitro. I. Kinetics of enhancement.
Herpes Simplex
DNA-mediated gene transfer in Chinese hamster ovary cells: clonal variation in transfer efficiency.
Herpes Simplex
DNA-mediated gene transfer in Friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA.
Herpes Simplex
DNA-mediated gene transfer without carrier DNA.
Herpes Simplex
DNA-mediated gene transfer: recombination between cotransferred DNA sequences and recovery of recombinants in a plasmid.
Herpes Simplex
DNA-transformed murine teratocarcinoma cells: regulation of expression of simian virus 40 tumor antigen in stem versus differentiated cells.
Herpes Simplex
Do there exist synergistic antitumor effects by coexpression of herpes simplex virus thymidine kinase with cytokine genes on human gastric cancer cell line SGC7901?
Herpes Simplex
Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene.
Herpes Simplex
Donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene: detailed immunological function following add-back after haplo-identical transplantation.
Herpes Simplex
Double cos site vectors: simplified cosmid cloning.
Herpes Simplex
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Herpes Simplex
Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model.
Herpes Simplex
Drosophila P element-enhanced transfection in mammalian cells.
Herpes Simplex
Drug resistance in the opportunistic pathogens Candida albicans and Candida glabrata.
Herpes Simplex
Drug resistance of herpes simplex virus type 1--structural considerations at the molecular level of the thymidine kinase.
Herpes Simplex
Dual-vector prodrug activator gene therapy using retroviral replicating vectors.
Herpes Simplex
Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture.
Herpes Simplex
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes.
Herpes Simplex
E1A RNA transcripts amplify adenovirus-mediated tumor reduction.
Herpes Simplex
E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.
Herpes Simplex
E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer.
Herpes Simplex
Early immune response against retrovirally transduced herpes simplex virus thymidine kinase-expressing gene-modified T cells coinfused with a T cell-depleted marrow graft: an altered immune response?
Herpes Simplex
Early immune response against retrovirally-transduced Herpes Simplex Virus-thymidine kinase-expressing gene-modified T cells coinfused with a T cell-depleted marrow graft : an altered immune response?
Herpes Simplex
EBV replicon vector system enhances transgene expression in vivo: applications to cancer gene therapy.
Herpes Simplex
Ecdysterone regulatory elements function as both transcriptional activators and repressors.
Herpes Simplex
Ectopic expression of herpes simplex virus-thymidine kinase gene in human non-small cell lung cancer cells conferred caspase-activated apoptosis sensitized by ganciclovir.
Herpes Simplex
Effect of a thymidine kinase inhibitor (L-653,180) on antiviral treatment of experimental herpes simplex virus infection in mice.
Herpes Simplex
Effect of acyclovir and presence of cellular and viral thymidine kinase activity in herpes simplex virus infected cells. Brief report.
Herpes Simplex
Effect of adenoviral-mediated thymidine kinase transduction and ganciclovir therapy on tumor-associated endothelial cells.
Herpes Simplex
Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability.
Herpes Simplex
Effect of butyrate on the expression of microinjected or transfected genes.
Herpes Simplex
Effect of combinations of antiviral drugs on herpes simplex encephalitis.
Herpes Simplex
Effect of combined cytostatic cyclosporin A and cytolytic suicide gene therapy on the prevention of experimental graft-versus-host disease.
Herpes Simplex
Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.
Herpes Simplex
Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect".
Herpes Simplex
Effect of in vitro mutations in a vaccinia virus early promoter region monitored by herpes simplex virus thymidine kinase expression in recombinant vaccinia virus.
Herpes Simplex
Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells.
Herpes Simplex
Effect of methylation on expression of microinjected genes.
Herpes Simplex
Effect of nucleotide excision repair in human cells on intrachromosomal homologous recombination induced by UV and 1-nitrosopyrene.
Herpes Simplex
Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma.
Herpes Simplex
Effect of the rabbit alphas1-casein gene distal enhancer on the expression of a reporter gene in vitro and in vivo.
Herpes Simplex
Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells.
Herpes Simplex
Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
Herpes Simplex
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.
Herpes Simplex
Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.
Herpes Simplex
Effects of an internal transcription unit and its orientation on retrovirus titre and expression.
Herpes Simplex
Effects of an upstream DNA curvature on the strength of HSV thymidine kinase promoter.
Herpes Simplex
Effects of bicistronic lentiviral vector-mediated herpes simplex virus thymidine kinase/ganciclovir system on human lens epithelial cells.
Herpes Simplex
Effects of deletions on expression of the herpes simplex virus thymidine kinase gene from the intact viral genome: the amino terminus of the enzyme is dispensable for catalytic activity.
Herpes Simplex
Effects of IMP dehydrogenase inhibitors on the phosphorylation of ganciclovir in MOLT-4 cells before and after herpes simplex virus thymidine kinase gene transduction.
Herpes Simplex
Effects of mutations on herpes simplex virus 1 thymidine kinase functionality: An in vitro assay based on detection of monophosphate forms of acyclovir and thymidine using HPLC/DAD.
Herpes Simplex
Effects of orientation and position on the activity of a herpes simplex virus immediate early gene far-upstream region.
Herpes Simplex
Effects of oxidative and alkylating damage on microsatellite instability in nontumorigenic human cells.
Herpes Simplex
Effects of retroviral-mediated herpes simplex virus thymidine kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo.
Herpes Simplex
Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes.
Herpes Simplex
Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-? and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line.
Herpes Simplex
Efficacy of 2'-nor-cyclicGMP in treatment of experimental herpes virus infections.
Herpes Simplex
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Herpes Simplex
Efficacy of lentivirus-mediated and MUC1 antibody-targeted VP22-TK/GCV suicide gene therapy for ovarian cancer.
Herpes Simplex
Efficacy of repeated adenoviral suicide gene therapy in a localized murine tumor model.
Herpes Simplex
Efficacy of the bystander effect in the herpes simplex virus thymidine kinase-mediated gene therapy is influenced by the expression of connexin43 in the target cells.
Herpes Simplex
Efficiency of introns from various origins in fish cells.
Herpes Simplex
Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication.
Herpes Simplex
Efficient expression of cloned complementary DNAs for secretory proteins after injection into Xenopus oocytes.
Herpes Simplex
Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site.
Herpes Simplex
Efficient gene delivery into epstein-barr virus (EBV)-transformed human B cells mediated by replication-defective herpes simplex virus-1 (HSV-1): A gene therapy model for EBV-related B cell malignancy.
Herpes Simplex
Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model.
Herpes Simplex
Efficient introduction of contents of liposomes into cells using HVJ (Sendai virus).
Herpes Simplex
Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR.
Herpes Simplex
Efficient repair of DNA double-strand breaks in malignant cells with structural instability.
Herpes Simplex
Efficient retroviral gene transfer of a Tat-regulated herpes simplex virus thymidine kinase gene for HIV gene therapy.
Herpes Simplex
Efficient suicide gene therapy of transduced and distant untransduced ovary tumors is correlated with significant increase of intratumoral T and NK cells.
Herpes Simplex
Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model.
Herpes Simplex
Efficient transcription of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is dependent on multiple promoter elements which can function bidirectionally.
Herpes Simplex
Efficient transformation of Dictyostelium discoideum amoebae.
Herpes Simplex
Electrophoresis of thymidine kinase activity synthesized by cells transformed by herpes simplex virus.
Herpes Simplex
Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase.
Herpes Simplex
Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response.
Herpes Simplex
Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene.
Herpes Simplex
Embryonic stem cell grafting in normal and infarcted myocardium: serial assessment with MR imaging and PET dual detection.
Herpes Simplex
Encapsidation and expression of the herpes thymidine kinase gene in polyoma virus.
Herpes Simplex
Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene.
Herpes Simplex
Encapsulation of packaging cell line results in successful retroviral-mediated transfer of a suicide gene in vivo in an experimental model of glioblastoma.
Herpes Simplex
Endogenous Neural Stem/Progenitor Cells Stabilize the Cortical Microenvironment after Traumatic Brain Injury.
Herpes Simplex
Engineered RNase P ribozymes increase their cleavage activities and efficacies in inhibiting viral gene expression in cells by enhancing the rate of cleavage and binding of the target mRNA.
Herpes Simplex
Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons.
Herpes Simplex
Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase.
Herpes Simplex
Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase.
Herpes Simplex
Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.
Herpes Simplex
Engineering of Systematic Elimination of a Targeted Chromosome in Human Cells.
Herpes Simplex
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase.
Herpes Simplex
Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma.
Herpes Simplex
Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter.
Herpes Simplex
Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.
Herpes Simplex
Enhanced ganciclovir killing and bystander effect of human tumor cells transduced with a retroviral vector carrying a herpes simplex virus thymidine kinase gene mutant.
Herpes Simplex
Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy.
Herpes Simplex
Enhanced growth suppression in esophageal carcinoma cells using adenovirus-mediated fusion gene transfer (uracil phosphoribosyl transferase and herpes simplex virus thymidine kinase).
Herpes Simplex
Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Enhanced rate of conversion or recombination of markers within a region of unique sequence in the herpes simplex virus genome.
Herpes Simplex
Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants.
Herpes Simplex
Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase.
Herpes Simplex
Enhancement of DNA-mediated gene transfer by inhibitors of autophagic-lysosomal function.
Herpes Simplex
Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator.
Herpes Simplex
Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.
Herpes Simplex
Enhancement of tumor killing using a combination of tumor immunization and HSV-tk suicide gene therapy.
Herpes Simplex
Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir.
Herpes Simplex
Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy.
Herpes Simplex
Entry of B lymphocytes into the persistent cell pool in non-immunized mice is not accompanied by somatic mutation of VH genes.
Herpes Simplex
Enzyme-targeted, nucleoside-based radiopharmaceuticals for scintigraphic monitoring of gene transfer and expression.
Herpes Simplex
Enzymology and pathogenicity in mice of a herpes simplex virus type 1 mutant resistant to 2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodocytosine.
Herpes Simplex
Epstein-Barr virus nuclear protein 2 transactivates a cis-acting CD23 DNA element.
Herpes Simplex
Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation.
Herpes Simplex
Epstein-Barr virus-based vector improves the tumor cell killing effect of pituitary tumor in HVJ-liposome-mediated transcriptional targeting suicide gene therapy.
Herpes Simplex
Eradication of murine brain tumors by direct inoculation of concentrated high titer-recombinant retrovirus harboring the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Herpes Simplex
Erratum to: Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Herpes Simplex
Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene.
Herpes Simplex
Establishment and use of a cell line expressing HSV-1 thymidine kinase to characterize viral thymidine kinase-dependent drug-resistance.
Herpes Simplex
Establishment of a rat cell line inducible for the expression of human cytomegalovirus immediate-early gene products by protein synthesis inhibition.
Herpes Simplex
Establishment of latency in mice by herpes simplex virus 1 recombinants that carry insertions affecting regulation of the thymidine kinase gene.
Herpes Simplex
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes.
Herpes Simplex
Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene.
Herpes Simplex
Establishment of parameters for optimal transduction efficiency and antitumor effects with purified high-titer HSV-TK retroviral vector in established solid tumors.
Herpes Simplex
Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators.
Herpes Simplex
Estrogen and progesterone receptor-binding sites on the chicken vitellogenin II gene: synergism of steroid hormone action.
Herpes Simplex
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.
Herpes Simplex
Evaluation of a C57BL/6J × 129S1/SvImJ Hybrid Nestin-Thymidine Kinase Transgenic Mouse Model for Studying the Functional Significance of Exercise-Induced Adult Hippocampal Neurogenesis.
Herpes Simplex
Evaluation of a putative vitamin D response element in the avian calcium binding protein gene.
Herpes Simplex
Evaluation of a viral thymidine kinase gene for suicide selection in transfected mosquito cells.
Herpes Simplex
Evaluation of an E1E4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy.
Herpes Simplex
Evaluation of combined gene regulatory elements for transcriptional targeting of suicide gene expression to malignant melanoma.
Herpes Simplex
Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging.
Herpes Simplex
Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors.
Herpes Simplex
Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer.
Herpes Simplex
Evaluation of herpes simplex virus 1 thymidine kinase-mediated trapping of (131)I FIAU and prodrug activation of ganciclovir as a synergistic cancer radio/chemotherapy.
Herpes Simplex
Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.
Herpes Simplex
Evaluation of prodrugs ability to induce effective ablation of cells transduced with viral thymidine kinase gene.
Herpes Simplex
Evaluation of Prostate-Specific Membrane Antigen as an Imaging Reporter.
Herpes Simplex
Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against Herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells.
Herpes Simplex
Evidence for a functional glucocorticoid responsive element in the Epstein-Barr virus genome.
Herpes Simplex
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Herpes Simplex
Evidence for an involvement of thymidine kinase in the excision repair of ultraviolet-irradiated herpes simplex virus in human cells.
Herpes Simplex
Evidence for intrachromosomal gene conversion in cultured mouse cells.
Herpes Simplex
Evidence for transcriptional interference in a dual-luciferase reporter system.
Herpes Simplex
Evidence that deletion of coding sequences in the 5' end of the thymidine kinase gene of herpes simplex virus type 1 affects the stability of the gene products.
Herpes Simplex
Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide.
Herpes Simplex
Ex vivo delivery of suicide genes into melanoma cells using epidermal growth factor receptor-specific Fab immunogene.
Herpes Simplex
Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.
Herpes Simplex
Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53.
Herpes Simplex
Experimental autoimmune encephalomyelitis repressed by microglial paralysis.
Herpes Simplex
Experimental gene therapy in mammary and urinary bladder cancer using electrogene transfer.
Herpes Simplex
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Herpes Simplex
Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.
Herpes Simplex
Expression and stabilization of microinjected plasmids containing the herpes simplex virus thymidine kinase gene and polyoma virus DNA in mouse cells.
Herpes Simplex
Expression from an internal AUG codon of herpes simplex thymidine kinase gene inserted in a retrovirus vector.
Herpes Simplex
Expression from herpesvirus promoters does not relieve the intron requirement for cytoplasmic accumulation of human beta-globin mRNA.
Herpes Simplex
Expression in COS-1 cells of Epstein-Barr virus nuclear antigen from a complete gene and a deleted gene.
Herpes Simplex
Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts.
Herpes Simplex
Expression of a mouse U1b gene in mouse L cells.
Herpes Simplex
Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment.
Herpes Simplex
Expression of a Tat-inducible herpes simplex virus-thymidine kinase gene protects acyclovir-treated CD4 cells from HIV-1 spread by conditional suicide and inhibition of reverse transcription.
Herpes Simplex
Expression of an immediate early polypeptide and activation of a viral origin of DNA replication in cells containing a fragment of herpes simplex virus DNA.
Herpes Simplex
Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene.
Herpes Simplex
Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.
Herpes Simplex
Expression of functional estrogen receptors and galanin messenger ribonucleic acid in immortalized luteinizing hormone-releasing hormone neurons: estrogenic control of galanin gene expression.
Herpes Simplex
Expression of H-2, laminin and SV40 T and TASA on differentiation of transformed murine teratocarcinoma cells.
Herpes Simplex
Expression of hepatitis B viral antigens in animal cells transfected with viral DNA.
Herpes Simplex
Expression of herpes simplex virus DNA fragments located in epidermal keratinocytes and germinative cells is associated with the development of erythema multiforme lesions.
Herpes Simplex
Expression of herpes simplex virus glycoprotein C from a DNA fragment inserted into the thymidine kinase gene of this virus.
Herpes Simplex
Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis.
Herpes Simplex
Expression of herpes simplex virus thymidine kinase in Toxoplasma gondii attenuates tachyzoite virulence in mice.
Herpes Simplex
Expression of herpes simplex virus thymidine kinase, mediated by vaccinia virus early promoters.
Herpes Simplex
Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay.
Herpes Simplex
Expression of herpes simplex virus type I thymidine kinase gene in Escherichia coli.
Herpes Simplex
Expression of herpes virus thymidine kinase in Neurospora crassa.
Herpes Simplex
Expression of human beta-interferon cDNA under the control of a thymidine kinase promoter from herpes simplex virus.
Herpes Simplex
Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector.
Herpes Simplex
Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.
Herpes Simplex
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
Herpes Simplex
Expression of porcine FSHbeta subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic rats.
Herpes Simplex
Expression of SV40 T antigen polypeptides in cells biochemically transformed by plasmids containing the herpes simplex virus thymidine kinase gene and the genome of an SV40tsA mutant.
Herpes Simplex
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.
Herpes Simplex
Expression of the cyclic AMP-dependent protein kinase (PKA) catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF.
Herpes Simplex
Expression of the glycoprotein of vesicular stomatitis virus by infectious adenovirus vectors.
Herpes Simplex
Expression of the Herpes simplex virus thymidine kinase gene in Saccharomyces cerevisiae.
Herpes Simplex
Expression of the herpes thymidine kinase gene in Xenopus laevis oocytes: an assay for the study of deletion mutants constructed in vitro.
Herpes Simplex
Expression of the human cardiac actin gene in differentiating rat skeletal myoblasts.
Herpes Simplex
Expression of the major histocompatibility antigens HLA-A2 and HLA-B7 by DNA-mediated gene transfer.
Herpes Simplex
Expression of the viral thymidine kinase gene in herpes simplex virus-transformed L cells.
Herpes Simplex
Expression of the X gene of hepatitis B virus.
Herpes Simplex
Expression of transferred thymidine kinase genes is controlled by methylation.
Herpes Simplex
Extensive vitiligo after ganciclovir treatment of GvHD in a patient who had received donor T cells expressing herpes simplex virus thymidine kinase.
Herpes Simplex
Ex Vivo Selection of Transduced Hematopoietic Stem Cells for Gene Therapy of ?-Hemoglobinopathies.
Herpes Simplex
Factors governing expression of the herpes simplex virus gene for thymidine kinase in clonal derivatives of transformed mouse L cells.
Herpes Simplex
Failure of founder transgenic male mice to transmit an attenuated HSV thymidine kinase transgene results from mosaicism and sperm competition.
Herpes Simplex
Fate and structure of DNA microinjected into mouse TK-L cells.
Herpes Simplex
Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys.
Herpes Simplex
Fertile homozygous transgenic mice expressing a functional truncated herpes simplex thymidine kinase delta TK gene.
Herpes Simplex
Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys.
Herpes Simplex
FIAU: From reporter gene imaging to imaging of bacterial proliferation.
Herpes Simplex
Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice.
Herpes Simplex
Fine-resolution analysis of products of intrachromosomal homeologous recombination in mammalian cells.
Herpes Simplex
Fine-structure analysis of the processing and polyadenylation region of the herpes simplex virus type 1 thymidine kinase gene by using linker scanning, internal deletion, and insertion mutations.
Herpes Simplex
Flagellar and acrosomal abnormalities associated with testicular HSV-tk expression in the mouse.
Herpes Simplex
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Herpes Simplex
Flt3L in Combination With HSV1-TK-mediated Gene Therapy Reverses Brain Tumor-induced Behavioral Deficits.
Herpes Simplex
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.
Herpes Simplex
Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model.
Herpes Simplex
Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.
Herpes Simplex
Folding and self-assembly of herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Foreign DNA introduced by calcium phosphate is integrated into repetitive DNA elements of the mouse L cell genome.
Herpes Simplex
Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus.
Herpes Simplex
From thallium scan to molecular imaging.
Herpes Simplex
Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo.
Herpes Simplex
Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.
Herpes Simplex
Functional analyses of albumin expression in a series of hepatocyte cell lines and in primary hepatocytes.
Herpes Simplex
Functional analysis of a transrepressor domain in the hepatitis C virus core protein.
Herpes Simplex
Functional analysis of the glucocorticoid regulatory elements present in the mouse mammary tumor virus long terminal repeat. A synthetic distal binding site can replace the proximal binding domain.
Herpes Simplex
Functional analysis of the mouse H-2Kb gene promoter in embryonal carcinoma cells.
Herpes Simplex
Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression.
Herpes Simplex
Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation.
Herpes Simplex
Functional expression of the Herpes simplex virus thymidine kinase gene in Escherichia coli K-12.
Herpes Simplex
Functional expression of thymidine kinase in human leukaemic and colorectal cells, delivered as EGFP fusion protein by herpesvirus saimiri-based vector.
Herpes Simplex
Functional genomics and radioisotope-based imaging procedures.
Herpes Simplex
Functional identification of genes up- and down-regulated by glucocorticoids in AtT-20 pituitary cells using an enhancer trap.
Herpes Simplex
Functional long-term thymidine kinase suicide gene expression in human T cells using a herpesvirus saimiri vector.
Herpes Simplex
Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus.
Herpes Simplex
Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.
Herpes Simplex
Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes.
Herpes Simplex
Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer.
Herpes Simplex
Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo.
Herpes Simplex
Fusion of herpes simplex virus thymidine kinase to VP22 does not result in intercellular trafficking of the protein.
Herpes Simplex
Fusion of the Human Immunodeficiency Virus Type 1 Tat Protein Transduction Domain to Thymidine Kinase Increases Bystander Effect and Induces Enhanced Tumor Killing In Vivo.
Herpes Simplex
Fusion of the human immunodeficiency virus type 1 tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo.
Herpes Simplex
Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth.
Herpes Simplex
Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice.
Herpes Simplex
Gamma interferon transduced 9L gliosarcoma. Cytokine gene therapy and its relevance to cellular therapy with alloreactive cytotoxic T lymphocytes.
Herpes Simplex
Gamma-rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/ganciclovir on cancer cells.
Herpes Simplex
Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP).
Herpes Simplex
Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinase-transformed baby hamster kidney cells.
Herpes Simplex
Ganciclovir mediated regression of rat brain tumors expressing the herpes simplex virus thymidine kinase imaged by magnetic resonance.
Herpes Simplex
Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer.
Herpes Simplex
Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation?
Herpes Simplex
Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase.
Herpes Simplex
Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis.
Herpes Simplex
Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Ganciclovir-sensitive acute graft-versus-host disease in mice receiving herpes simplex virus-thymidine kinase-expressing donor T cells in a bone marrow transplantation setting.
Herpes Simplex
Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene.
Herpes Simplex
Gap junctions in human glioblastomas: implications for suicide gene therapy.
Herpes Simplex
Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.
Herpes Simplex
Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo.
Herpes Simplex
GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the Tat8-TK as a late gene in a pancreatic tumour model.
Herpes Simplex
GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity.
Herpes Simplex
Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy.
Herpes Simplex
Gene and cell therapy for relapsed leukemia after allo-stem cell transplantation.
Herpes Simplex
Gene and other biological therapies for vascular diseases.
Herpes Simplex
Gene delivery by HVJ-liposome in the experimental gene therapy of murine glioma.
Herpes Simplex
Gene delivery by lentivirus vectors an overview.
Herpes Simplex
Gene delivery to carcinoma cells via novel non-viral vectors: nanoparticle tracking analysis and suicide gene therapy.
Herpes Simplex
Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus.
Herpes Simplex
Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
Herpes Simplex
Gene stereotactic neurosurgery for recurrent malignant gliomas.
Herpes Simplex
Gene targeting by a vector with hairpin-shaped oligonucleotide caps.
Herpes Simplex
Gene Targeting to Hepatomas (AFP).
Herpes Simplex
Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: inactivation of the mouse ERCC-1 gene.
Herpes Simplex
Gene therapeutic approaches for medullary thyroid carcinoma treatment.
Herpes Simplex
Gene therapy against an experimental glioma using adeno-associated virus vectors.
Herpes Simplex
Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.
Herpes Simplex
Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1.
Herpes Simplex
Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Gene therapy for brain tumors.
Herpes Simplex
Gene therapy for brain tumors: Basic developments and clinical implementation.
Herpes Simplex
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.
Herpes Simplex
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Herpes Simplex
Gene therapy for colon cancer with the herpes simplex thymidine kinase gene.
Herpes Simplex
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Herpes Simplex
Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir.
Herpes Simplex
Gene therapy for hepatocellular carcinoma based on tumour-selective suicide gene expression using the alpha-fetoprotein (AFP) enhancer and a housekeeping gene promoter.
Herpes Simplex
Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with alpha-fetoprotein promoter and Cre/lox P system.
Herpes Simplex
Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.
Herpes Simplex
Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter.
Herpes Simplex
Gene therapy for high grade gliomas.
Herpes Simplex
Gene therapy for malignant mesothelioma: a novel approach for an incurable cancer with increased incidence in Louisiana.
Herpes Simplex
Gene therapy for malignant pleural mesothelioma.
Herpes Simplex
Gene therapy for metastatic malignant melanoma: evaluation of tolerance to intratumoral injection of cells producing recombinant retroviruses carrying the herpes simplex virus type 1 thymidine kinase gene, to be followed by ganciclovir administration.
Herpes Simplex
Gene therapy for oral cancer: efficient delivery of a 'suicide gene' to murine oral cancer cells in physiological milieu.
Herpes Simplex
Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Herpes Simplex
Gene therapy for prostate cancer: toxicological profile of four HSV-tk transducing adenoviral vectors regulated by different promoters.
Herpes Simplex
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir.
Herpes Simplex
Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Herpes Simplex
Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Herpes Simplex
Gene therapy in brain tumours: implications of the size of glioblastoma on its curability.
Herpes Simplex
Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.
Herpes Simplex
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
Herpes Simplex
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Gene therapy of epithelial ovarian cancer using adenoviral vectors.
Herpes Simplex
Gene therapy of established medullary thyroid carcinoma with herpes simplex viral thymidine kinase in a rat tumor model: relationship of bystander effect and antitumor efficacy.
Herpes Simplex
Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene.
Herpes Simplex
Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene.
Herpes Simplex
Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir.
Herpes Simplex
Gene therapy of HSV-TK transferred by the EBV based expression vector on experimental hepatocellular carcinoma.
Herpes Simplex
Gene therapy of liver tumors with human liver-specific nanoparticles.
Herpes Simplex
Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells.
Herpes Simplex
Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir.
Herpes Simplex
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.
Herpes Simplex
Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging.
Herpes Simplex
Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.
Herpes Simplex
Gene Therapy of Uterine Leiomyoma: Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Treatment Inhibits Growth of Human and Rat Leiomyoma Cells in vitro and in a Nude Mouse Model.
Herpes Simplex
Gene therapy strategies for leukemia.
Herpes Simplex
Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.
Herpes Simplex
Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect.
Herpes Simplex
Gene therapy using tissue-specific replication competent HSV.
Herpes Simplex
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Herpes Simplex
Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin.
Herpes Simplex
Gene therapy vectors harboring AFP regulatory sequences. Preparation of an adenoviral vector.
Herpes Simplex
Gene therapy with GM-CSF, interleukin-4 and herpes simplex virus thymidine kinase shows strong antitumor effect on lung cancer.
Herpes Simplex
Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells.
Herpes Simplex
Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Herpes Simplex
Gene transfer applied to the modulation of alloreactivity.
Herpes Simplex
Gene transfer in bovine blastocysts using replication-defective retroviral vectors packaged with Gibbon ape leukemia virus envelopes.
Herpes Simplex
Gene transfer into human prostate adenocarcinoma cells with an adenoviral vector: Hyperthermia enhances a double suicide gene expression, cytotoxicity and radiotoxicity.
Herpes Simplex
Gene transfer into mouse lyoma cells by electroporation in high electric fields.
Herpes Simplex
Gene transfer into sympathetic preganglionic neurons in vivo using a non-replicating thymidine kinase-deficient herpes simplex virus type 1.
Herpes Simplex
Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors.
Herpes Simplex
Gene transfer, expression, and molecular cloning of the human transferrin receptor gene.
Herpes Simplex
Gene transfer: DNA microinjection compared with DNA transfection with a very high efficiency.
Herpes Simplex
Gene trap screening using negative selection: identification of two tandem, differentially expressed loci with potential hematopoietic function.
Herpes Simplex
Generation of a helper cell line for packaging avian leukosis virus-based vectors.
Herpes Simplex
Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression.
Herpes Simplex
Generation of destabilized herpes simplex virus type 1 thymidine kinase as transcription reporter for PET reporter systems in molecular genetic imaging.
Herpes Simplex
Generation of fusion genes carrying drug resistance, green fluorescent protein, and herpes simplex virus thymidine kinase genes in a single cistron.
Herpes Simplex
Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa.
Herpes Simplex
Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations.
Herpes Simplex
Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence.
Herpes Simplex
Genetic and physical evidence for the polarity of transcription of the thymidine kinase gene of herpes simplex virus.
Herpes Simplex
Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients.
Herpes Simplex
Genetic determinants of growth phase-dependent and adenovirus 5-responsive expression of the Chinese hamster thymidine kinase gene are contained within thymidine kinase mRNA sequences.
Herpes Simplex
Genetic incorporation of a herpes simplex virus type 1 thymidine kinase and firefly luciferase fusion into the adenovirus protein IX for functional display on the virion.
Herpes Simplex
Genetic incorporation of HSV-1 thymidine kinase into the adenovirus protein IX for functional display on the virion.
Herpes Simplex
Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques.
Herpes Simplex
Genetic rearrangements occurring during a single cycle of murine leukemia virus vector replication: characterization and implications.
Herpes Simplex
Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility.
Herpes Simplex
Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas.
Herpes Simplex
Genetically engineered suicide gene in mesenchymal stem cells using a Tet-On system for anaplastic thyroid cancer.
Herpes Simplex
Genetically modified CD34+ cells exert a cytotoxic bystander effect on human endothelial and cancer cells.
Herpes Simplex
Genetically Modified Donor Leukocyte Transfusion and Graft-Versus-Leukemia Effect After Allogeneic Stem Cell Transplantation.
Herpes Simplex
Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice.
Herpes Simplex
GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.
Herpes Simplex
Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells with Zinc Finger Nuclease for Cellular Imaging.
Herpes Simplex
Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain.
Herpes Simplex
Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals.
Herpes Simplex
Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.
Herpes Simplex
Germline transmission of exogenous genes in the chicken.
Herpes Simplex
GFAP Transgenic Mice
Herpes Simplex
Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity.
Herpes Simplex
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Herpes Simplex
Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.
Herpes Simplex
Glucocorticoid regulation of a transcription factor that binds an initiator-like element in the murine thymidine kinase (Tk-1) promoter.
Herpes Simplex
Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.
Herpes Simplex
Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.
Herpes Simplex
Glucocorticoid repression of 3',5'-cyclic-adenosine monophosphate-dependent human corticotropin-releasing-hormone gene promoter activity in a transfected mouse anterior pituitary cell line.
Herpes Simplex
Glucocorticoids enhance stability of human growth hormone mRNA.
Herpes Simplex
Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining.
Herpes Simplex
Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment.
Herpes Simplex
Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene.
Herpes Simplex
Granulocyte-macrophage colony-stimulating factor in a combination gene therapy strategy for head and neck cancer.
Herpes Simplex
Graphene oxide-hydroxyapatite nanocomposites effectively deliver HSV-TK suicide gene to inhibit human breast cancer growth.
Herpes Simplex
HDAC inhibitor valproic acid enhances tumor cell kill in adenovirus-HSVtk mediated suicide gene therapy in HNSCC xenograft mouse model.
Herpes Simplex
Heat-directed suicide gene therapy mediated by heat shock protein promoter for gastric cancer.
Herpes Simplex
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Herpes Simplex
Hemimethylation of DNA prevents chromatin expression.
Herpes Simplex
Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences.
Herpes Simplex
Hepatoma-specific gene therapy through retrovirus-mediated and targeted gene transfer using an adenovirus carrying the ecotropic receptor gene.
Herpes Simplex
Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes.
Herpes Simplex
Herpes simplex thymidine kinase gene transfer is required for complete regression of murine colon adenocarcinoma.
Herpes Simplex
Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions.
Herpes Simplex
Herpes simplex virus (type 1) thymidine kinase gene does not transform cells morphologically.
Herpes Simplex
Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice.
Herpes Simplex
Herpes simplex virus as a source of thymidine kinase for thymidine kinase-deficient mouse cells: suppression and reactivation of the viral enzyme.
Herpes Simplex
Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus.
Herpes Simplex
Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus.
Herpes Simplex
Herpes simplex virus thymidine kinase activity of thymidine kinase-deficient Escherichia coli K-12 mutant transformed by hybrid plasmids.
Herpes Simplex
Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer.
Herpes Simplex
Herpes simplex virus thymidine kinase and granulocyte macrophage colony-stimulating factor combination gene therapy in a murine CT26 cell colon cancer model.
Herpes Simplex
Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Herpes Simplex
Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy.
Herpes Simplex
Herpes simplex virus thymidine kinase enzymatic assay in transient transfection experiments using thymidine kinase-deficient cells.
Herpes Simplex
Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.
Herpes Simplex
Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation.
Herpes Simplex
Herpes simplex virus thymidine kinase gene is stably maintained and expressed in cells transformed by protoplast fusion.
Herpes Simplex
Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors.
Herpes Simplex
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
Herpes Simplex
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.
Herpes Simplex
Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors.
Herpes Simplex
Herpes simplex virus thymidine kinase imaging in mice with (1-(2'-deoxy-2'-[(18)F]fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil) and metabolite (1-(2'-deoxy-2'-[(18)F]fluoro-1-beta-D-arabinofuranosyl)-5-uracil).
Herpes Simplex
Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis study.
Herpes Simplex
Herpes simplex virus thymidine kinase transcripts are absent from both nucleus and cytoplasm during infection in the presence of cycloheximide.
Herpes Simplex
Herpes simplex virus thymidine kinase-green fluorescent protein fusion gene: new tool for gene transfer studies and gene therapy.
Herpes Simplex
Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound.
Herpes Simplex
Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells.
Herpes Simplex
Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.
Herpes Simplex
Herpes simplex virus thymidine kinase/ganciclovir-mediated killing of tumor cell induces tumor-specific cytotoxic T cells in mice.
Herpes Simplex
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Herpes Simplex
Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Herpes Simplex
Herpes simplex virus type 1 thymidine kinase gene expression in Escherichia coli.
Herpes Simplex
Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.
Herpes Simplex
Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models.
Herpes Simplex
Herpes simplex virus type 1 UL46 and UL47 deletion mutants lack VP11 and VP12 or VP13 and VP14, respectively, and exhibit altered viral thymidine kinase expression.
Herpes Simplex
Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation.
Herpes Simplex
Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.
Herpes Simplex
Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis.
Herpes Simplex
Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing.
Herpes Simplex
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Herpes Simplex
Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection.
Herpes Simplex
Herpesvirus saimiri pathogenicity enhanced by thymidine kinase of herpes simplex virus.
Herpes Simplex
Herpesvirus thymidine kinase transgenes that do not cause male sterility are aberrantly transcribed and translated in the testis.
Herpes Simplex
Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.
Herpes Simplex
High efficiency of replication and expression of foreign genes in SV40-transformed human fibroblasts.
Herpes Simplex
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells.
Herpes Simplex
High Mobility Group Box2 Promoter-controlled Suicide Gene Expression Enables Targeted Glioblastoma Treatment.
Herpes Simplex
High mobility group proteins 1 and 2 function as general class II transcription factors.
Herpes Simplex
High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.
Herpes Simplex
High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.
Herpes Simplex
High-efficiency genome editing and allele replacement in prototrophic and wild strains of Saccharomyces.
Herpes Simplex
High-frequency deletion in recovered retrovirus vectors containing exogenous DNA with promoters.
Herpes Simplex
High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells.
Herpes Simplex
High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant.
Herpes Simplex
High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion.
Herpes Simplex
High-intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene-loaded ultrasound-targeted microbubbles improved survival of rabbit with VX2 liver tumor.
Herpes Simplex
High-level transgene expression mediated by the piggyBac transposon enhances transgenic therapeutic effects in cervical cancer xenografts.
Herpes Simplex
Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors.
Herpes Simplex
Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes.
Herpes Simplex
Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors.
Herpes Simplex
Highly efficient suicide gene expression in hepatocellular carcinoma cells by epstein-barr virus-based plasmid vectors combined with polyamidoamine dendrimer.
Herpes Simplex
Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives.
Herpes Simplex
Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues.
Herpes Simplex
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Highly-efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin.
Herpes Simplex
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Herpes Simplex
Homing and survival of thymidine kinase-transduced human T cells in NOD/SCID mice.
Herpes Simplex
Homo-FRET microscopy in living cells to measure monomer-dimer transition of GFP-tagged proteins.
Herpes Simplex
Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.
Herpes Simplex
Homologous recombination between overlapping thymidine kinase gene fragments stably inserted into a mouse cell genome.
Herpes Simplex
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
Herpes Simplex
Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells.
Herpes Simplex
Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.
Herpes Simplex
Hormonal induction of transfected genes depends on DNA topology.
Herpes Simplex
Hormonally mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L cells.
Herpes Simplex
Host-specificities of papillomavirus, Moloney murine sarcoma virus and simian virus 40 enhancer sequences.
Herpes Simplex
HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.
Herpes Simplex
HSV-1 Vectors for Gene Therapy of Experimental CNS Tumors.
Herpes Simplex
HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells.
Herpes Simplex
HSV-tk gene therapy for human renal cell carcinoma in nude mice.
Herpes Simplex
HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect.
Herpes Simplex
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia.
Herpes Simplex
HSV-TK/IL-2 gene therapy for glioblastoma multiforme.
Herpes Simplex
HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1?pAFP-TK and targeted killing effect.
Herpes Simplex
Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.
Herpes Simplex
Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models.
Herpes Simplex
Human beta-globin gene sequences injected into mouse eggs, retained in adults, and transmitted to progeny.
Herpes Simplex
Human breast tumor cells express multimodal imaging reporter genes.
Herpes Simplex
Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site.
Herpes Simplex
Human embryonic stem cell-derived cardiomyocyte therapy in mouse permanent ischemia and ischemia-reperfusion models.
Herpes Simplex
Human Embryonic Stem Cell-Derived Endothelial Cells as Cellular Delivery Vehicles for Treatment of Metastatic Breast Cancer.
Herpes Simplex
Human Embryonic Stem Cell-derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma.
Herpes Simplex
Human epithelial ovarian cancer xenotransplants into nude mice can be cured by adenovirus-mediated thymidine kinase gene therapy.
Herpes Simplex
Human estrogen receptor introduced into the Xenopus oocyte represses expression from an artificial frog estrogen response element.
Herpes Simplex
Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy.
Herpes Simplex
Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice.
Herpes Simplex
Human growth hormone as a reporter gene in regulation studies employing transient gene expression.
Herpes Simplex
Human HLA-specific T-cell clones with stable expression of a suicide gene: a possible tool to drive and control a graft-versus-host- graft-versus-leukemia reaction?
Herpes Simplex
Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region.
Herpes Simplex
Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy.
Herpes Simplex
Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.
Herpes Simplex
Human NT2 Neural Precursor-Derived Tumor-Infiltrating Cells as Delivery Vehicles for Treatment of Glioblastoma.
Herpes Simplex
Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression.
Herpes Simplex
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.
Herpes Simplex
Human reporter genes: potential use in clinical studies.
Herpes Simplex
Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.
Herpes Simplex
Human Wharton's jelly-derived mesenchymal stromal cells engineered to secrete Epstein-Barr virus interleukin-10 show enhanced immunosuppressive properties.
Herpes Simplex
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1.
Herpes Simplex
Hybrid protein thymidine kinase gene fusions: plasmid vectors for the study of transcription and translation initiation signals.
Herpes Simplex
Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes.
Herpes Simplex
Hydroxyurea induces bystander cytotoxicity in cocultures of herpes simplex virus thymidine kinase-expressing and nonexpressing HeLa cells incubated with ganciclovir.
Herpes Simplex
Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer.
Herpes Simplex
Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy.
Herpes Simplex
Identification and characterization of a novel transcriptional silencer in the human collagen type IV gene COL4A2.
Herpes Simplex
Identification and characterization of an enhancer in the coding region of the genome of human immunodeficiency virus type 1.
Herpes Simplex
Identification and characterization of the cis-elements regulating the rat AMOG (adhesion molecule on glia)/Na,K-ATPase beta 2 subunit gene.
Herpes Simplex
Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the thymidine kinase and UL24 genes of herpes simplex virus type 1.
Herpes Simplex
Identification and functional characterization of an erythroid-specific enhancer in the L-type pyruvate kinase gene.
Herpes Simplex
Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapy.
Herpes Simplex
Identification and mapping of two polypeptides encoded within the herpes simplex virus type 1 thymidine kinase gene sequences.
Herpes Simplex
Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase.
Herpes Simplex
Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.
Herpes Simplex
Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNA.
Herpes Simplex
Identification of a glucocorticoid-responsive element in Epstein-Barr virus.
Herpes Simplex
Identification of a high molecular weight steroid response element binding protein.
Herpes Simplex
Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene.
Herpes Simplex
Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus.
Herpes Simplex
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
Herpes Simplex
Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells.
Herpes Simplex
Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene.
Herpes Simplex
Identification of a placental-specific enhancer in the rat placental lactogen II gene that contains binding sites for members of the Ets and AP-1 (activator protein 1) families of transcription factors.
Herpes Simplex
Identification of a silencing element in the chicken lipoprotein lipase gene promoter: characterization of the silencer-binding protein and delineation of its target nucleotide sequence.
Herpes Simplex
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene.
Herpes Simplex
Identification of an estrogen-responsive element in the rat LH beta gene. DNA-estrogen receptor interactions and functional analysis.
Herpes Simplex
Identification of DNA sequence responsible for 5-bromodeoxyuridine-induced gene amplification.
Herpes Simplex
Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach.
Herpes Simplex
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Herpes Simplex
Identification of glucocorticoid-responsive elements that control transcription of rat glutamine synthetase.
Herpes Simplex
Identification of human genomic clones coding the major histocompatibility antigens HLA-a2 and HLA-B7 by DNA-mediated gene transfer.
Herpes Simplex
Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.
Herpes Simplex
Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro.
Herpes Simplex
Identification of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene.
Herpes Simplex
Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA.
Herpes Simplex
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.
Herpes Simplex
Identification of sequences involved in the transcriptional control of a Drosophila heat-shock gene.
Herpes Simplex
Identification of the 12-O-tetradecanoylphorbol-13-acetate-responsive enhancer of the MS gene of the Epstein-Barr virus.
Herpes Simplex
Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines.
Herpes Simplex
Identification of the thymidine kinase gene of infectious laryngotracheitis virus.
Herpes Simplex
IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.
Herpes Simplex
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
Herpes Simplex
Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography.
Herpes Simplex
Imaging Chemically Modified Adenovirus for Targeting Tumors Expressing Integrin {alpha}v{beta}3 in Living Mice with Mutant Herpes Simplex Virus Type 1 Thymidine Kinase PET Reporter Gene.
Herpes Simplex
Imaging Gene Expression in Human Mesenchymal Stem Cells: From Small to Large Animals.
Herpes Simplex
Imaging herpes viral thymidine kinase-1 reporter gene expression with a new 18F-labeled probe: 2'-fluoro-2'-deoxy-5-[18F]fluoroethyl-1-beta-d-arabinofuranosyl uracil.
Herpes Simplex
Imaging in vivo herpes simplex virus thymidine kinase gene transfer to tumour-bearing rodents using positron emission tomography and.
Herpes Simplex
Imaging methods in gene therapy of cancer.
Herpes Simplex
Imaging Neural Stem Cell Graft-Induced Structural Repair in Stroke.
Herpes Simplex
Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir.
Herpes Simplex
Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography.
Herpes Simplex
Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.
Herpes Simplex
Imaging pulmonary gene expression with positron emission tomography.
Herpes Simplex
Imaging the expression of transfected genes in vivo.
Herpes Simplex
Imaging the spatial distribution of transgene expression in the lungs with positron emission tomography.
Herpes Simplex
Imaging transgene expression with radionuclide imaging technologies.
Herpes Simplex
Imaging tri-fusion multimodality reporter gene expression in living subjects.
Herpes Simplex
Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.
Herpes Simplex
Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis.
Herpes Simplex
Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2.
Herpes Simplex
Immunization with live HPV-16-transformed mouse cells expressing the herpes simplex thymidine kinase and either GM-CSF or IL-2.
Herpes Simplex
Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery.
Herpes Simplex
Immunogenicity versus pathogenicity after anterior chamber inoculation of an acyclovir-induced double mutant of HSV-1.
Herpes Simplex
Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.
Herpes Simplex
Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation.
Herpes Simplex
Immunomodulation of glioma cells after gene therapy: induction of major histocompatibility complex class I but not class II antigen in vitro.
Herpes Simplex
Immunosuppression promotes ocular virus replication and CNS neurovirulence following corneal inoculation with an avirulent herpes simplex type 1 thymidine kinase negative mutant.
Herpes Simplex
Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy.
Herpes Simplex
Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma.
Herpes Simplex
Implication of in vivo circulating fibrocytes ablation in experimental pulmonary hypertension murine model.
Herpes Simplex
Importance of C-terminus of herpes simplex virus type 1 thymidine kinase for maintaining thymidine kinase and acyclovir-phosphorylation activities.
Herpes Simplex
Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice.
Herpes Simplex
Improved gene expression by a modified bicistronic retroviral vector.
Herpes Simplex
Improved gene expression by a U3-based retroviral vector.
Herpes Simplex
Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes.
Herpes Simplex
Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate.
Herpes Simplex
Improved safety of a replication-competent poxvirus-based HIV vaccine with the introduction of the HSV-TK/GCV suicide gene system.
Herpes Simplex
Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide.
Herpes Simplex
Improvement of the dP-nucleoside-mediated herpes simplex virus thymidine kinase negative-selection system by manipulating dP metabolism genes.
Herpes Simplex
Improving the safety of cell therapy with the TK-suicide gene.
Herpes Simplex
In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.
Herpes Simplex
In situ gene therapy for prostate cancer.
Herpes Simplex
In situ gene transfer and suicide gene therapy of gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in dogs.
Herpes Simplex
In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.
Herpes Simplex
In situ polymerase chain reaction: localization of HSV-2 DNA sequences in infections of the nervous system.
Herpes Simplex
In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery.
Herpes Simplex
In situ use of suicide genes for cancer therapy.
Herpes Simplex
In vitro activity of polyhydroxycarboxylates against herpesviruses and HIV.
Herpes Simplex
In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma.
Herpes Simplex
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
Herpes Simplex
In vitro and in vivo effects of retrovirus-mediated transfer of the connexin 43 gene in malignant gliomas: consequences for HSVtk/GCV anticancer gene therapy.
Herpes Simplex
In vitro and in vivo evaluation of novel cationic liposomes utilized for cancer gene therapy.
Herpes Simplex
In vitro evaluation of herpes simplex virus type 1 thymidine kinase reporter system in dynamic studies of transcriptional gene regulation.
Herpes Simplex
In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy.
Herpes Simplex
In vitro model of suicide gene therapy for alpha-fetoprotein-producing gastric cancer.
Herpes Simplex
In vitro selection of external guide sequences for directing RNase P-mediated inhibition of viral gene expression.
Herpes Simplex
In vitro selection of RNase P ribozymes that efficiently cleave a target mRNA.
Herpes Simplex
In vitro sensitization of the B16 murine melanoma cells to ganciclovir by different RNA and plasmid DNA constructions encoding HSVtk.
Herpes Simplex
In vitro suppression of UAG and UGA mutants in the thymidine kinase gene of herpes simplex virus.
Herpes Simplex
In vitro thymidine kinase/ganciclovir-based suicide gene therapy using replication defective herpes simplex virus-1 against leukemic B-cell malignancies (MCL, HCL, B-CLL).
Herpes Simplex
In vitro transcription of the thymidine kinase gene of herpes simplex virus.
Herpes Simplex
In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene.
Herpes Simplex
In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer.
Herpes Simplex
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
Herpes Simplex
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha.
Herpes Simplex
In vivo antitumor effect of herpes simplex virus thymidine kinase gene therapy in rat hepatocellular carcinoma: feasibility of adenovirus-mediated intra-arterial gene delivery.
Herpes Simplex
In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020: construction and evaluation in rodents.
Herpes Simplex
In vivo characterization of a prostate-specific antigen promoter-based suicide gene therapy for the treatment of benign prostatic hyperplasia.
Herpes Simplex
In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats.
Herpes Simplex
In vivo demethylation of a MoMuLV retroviral vector expressing the herpes simplex thymidine kinase suicide gene by 5' azacytidine.
Herpes Simplex
In vivo drug-selectable markers in gene therapy.
Herpes Simplex
In vivo efficacy of HSV-TK transcriptionally targeted to the tumour vasculature is augmented by combination with cytotoxic chemotherapy.
Herpes Simplex
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
Herpes Simplex
In vivo gene delivery to tumor cells by transferrin-streptavidin-DNA conjugate.
Herpes Simplex
In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration.
Herpes Simplex
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.
Herpes Simplex
In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU.
Herpes Simplex
In vivo Imaging of the Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors.
Herpes Simplex
In vivo labeling of fission yeast DNA with thymidine and thymidine analogs.
Herpes Simplex
In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus.
Herpes Simplex
In vivo molecular imaging characterizes pulmonary gene expression during experimental lung transplantation.
Herpes Simplex
In vivo molecular imaging of murine embryonic stem cells delivered to a burn wound surface via Integra® scaffolding.
Herpes Simplex
In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells.
Herpes Simplex
In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model.
Herpes Simplex
In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
Herpes Simplex
In vivo surgical resection plus adjuvant gene therapy in the treatment of mammary and prostate cancer.
Herpes Simplex
In vivo transfer of a foreign gene to keratinocytes using the hemagglutinating virus of Japan-liposome method.
Herpes Simplex
In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors.
Herpes Simplex
In-vitro synthesis of functional varicella zoster and herpes simplex viral thymidine kinase.
Herpes Simplex
Incidence and distribution of herpes simplex virus types 1 and 2 from genital lesions in college women.
Herpes Simplex
Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy.
Herpes Simplex
Incorporation into nucleic acids of the antiherpes guanosine analog buciclovir, and effects on DNA and protein synthesis.
Herpes Simplex
Increase in DNA vaccine efficacy by virosome delivery and co-expression of a cytolytic protein.
Herpes Simplex
Increased bax expression is associated with cell death induced by ganciclovir in a herpes thymidine kinase gene-expressing glioma cell line.
Herpes Simplex
Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells.
Herpes Simplex
Increased efficiency of cisplatin-resistant cell lines to DNA-mediated gene transfer with cationic liposome.
Herpes Simplex
Increased glioma growth in mice depleted of macrophages.
Herpes Simplex
Indirect monitoring of endogenous gene expression by positron emission tomography (PET) imaging of reporter gene expression in transgenic mice.
Herpes Simplex
Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene.
Herpes Simplex
Induced ablation of gonadotropins in transgenic mice expressing herpes simplex virus thymidine kinase under the FSH beta-subunit promoter.
Herpes Simplex
Induced expression of the conditionally cytotoxic herpes simplex virus thymidine kinase gene by means of a parvoviral regulatory circuit.
Herpes Simplex
Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy.
Herpes Simplex
Inducible expression of herpes simplex virus thymidine kinase from a bicistronic HIV1 vector.
Herpes Simplex
Inducible expression of herpes simplex virus thymidine kinase increases sensitivity to ganciclovir but does not enhance bystander effect in breast cancer cells.
Herpes Simplex
Inducible expression of suicide genes in Leishmania donovani amastigotes.
Herpes Simplex
Inducible liver injury in the transgenic rat by expressing liver-specific suicide gene.
Herpes Simplex
Induction capacity and influence of dThdMP on thymidine kinase activity of type 1 and 2 strains of herpes simplex virus.
Herpes Simplex
Induction of a bystander effect in HeLa cells by using a bigenic vector carrying viral thymidine kinase and connexin32 genes.
Herpes Simplex
Induction of cell death in activated hepatic stellate cells by targeted gene expression of the thymidine kinase/ganciclovir system.
Herpes Simplex
Induction of deoxypyrimidine kinase activity in human embryonic lung cells infected with varicella-zoster virus.
Herpes Simplex
Induction of human beta-interferon synthesis with poly(rI . rC) in mouse cells transfected with cloned cDNA plasmids.
Herpes Simplex
Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.
Herpes Simplex
Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Herpes Simplex
Inflammatory thoughts about glioma gene therapy.
Herpes Simplex
Influence of different promoters on the expression of tumor-necrosis-factor-alpha in ls174t human colon-carcinoma cells.
Herpes Simplex
Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus.
Herpes Simplex
Influence of p53 status on the HSV-Tk/GCV-induced bystander effect in a panel of human ovarian carcinoma cell lines.
Herpes Simplex
Influence of the bystander effect on HSV-tk/GCV gene therapy. A review.
Herpes Simplex
Influence of the embryonic preplate on the organization of the cerebral cortex: a targeted ablation model.
Herpes Simplex
Information transfer between duplicated chromosomal sequences in mammalian cells involves contiguous regions of DNA.
Herpes Simplex
Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Herpes Simplex
Inhibition by interferon of biochemical transformation induced by cloned herpesvirus thymidine kinase genes.
Herpes Simplex
Inhibition by interferon of herpes simplex virus thymidine kinase and DNA polymerase in infected and biochemically transformed cells.
Herpes Simplex
Inhibition of ATP-sensitive potassium channels increases HSV-tk/GCV bystander effect in U373 human glioma cells by enhancing gap junctional intercellular communication.
Herpes Simplex
Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy?
Herpes Simplex
Inhibition of gene expression by a short sense fragment.
Herpes Simplex
Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter.
Herpes Simplex
Inhibition of graft-versus-host disease. Use of a T cell-controlled suicide gene.
Herpes Simplex
Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect.
Herpes Simplex
Inhibition of herpes simplex virus reactivation by dipyridamole in a mouse model.
Herpes Simplex
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.
Herpes Simplex
Inhibition of herpes simplex virus type 1 DNA polymerase by [1R(1 alpha,2 beta,3 alpha)]-9-[2,3-bis(hydroxymethyl)cyclobutyl] guanine.
Herpes Simplex
Inhibition of HIV-1 multiplication in a human CD4+ lymphocytic cell line expressing antisense and sense RNA molecules containing HIV-1 packaging signal and Rev response element(s).
Herpes Simplex
Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.
Herpes Simplex
Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
Herpes Simplex
Inhibition of plasmid reporter gene expression in CHO cells by DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Herpes Simplex
Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts.
Herpes Simplex
Inhibition of promoter activity by methylation: possible involvement of protein mediators.
Herpes Simplex
Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment.
Herpes Simplex
Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease.
Herpes Simplex
Inhibition of the herpes simplex virus thymidine kinase gene transfection in Ltk- cells by potential Z-DNA forming polymers.
Herpes Simplex
Inhibition of the herpes simplex virus-coded thymidine kinase-complex by 9-beta-D-arabinofuranosyladenine 5'-monophosphate (ara-AMP) and 9-(2-hydroxyethoxymethyl)guanine-monophosphate (acyclo-GMP).
Herpes Simplex
Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms.
Herpes Simplex
Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor.
Herpes Simplex
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Herpes Simplex
Inhibition of tumor growth by direct intratumoral gene transfer of herpes simplex virus thymidine kinase gene with DNA-liposome complexes.
Herpes Simplex
Inhibition of viral and cellular promoters by human wild-type p53.
Herpes Simplex
Inhibition of viral gene expression by human ribonuclease P.
Herpes Simplex
Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.
Herpes Simplex
Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo.
Herpes Simplex
Inhibitory effect of cycloSaligenyl-nucleoside monophosphates (cycloSal-NMP) of acyclic nucleoside analogues on HSV-1 and EBV.
Herpes Simplex
Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.
Herpes Simplex
Initiation of herpes simplex virus thymidine kinase polypeptides.
Herpes Simplex
Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Innovative strategies for the treatment of thyroid cancer.
Herpes Simplex
Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis.
Herpes Simplex
Insertion and deletion mutants of vaccinia virus.
Herpes Simplex
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.
Herpes Simplex
Insertion of a new gene of viral origin into bone marrow cells of mice.
Herpes Simplex
Insertion of new genes into bone marrow cells of mice.
Herpes Simplex
Insertion sites for recombinant vaccinia virus construction: effects on expression of a foreign protein.
Herpes Simplex
Insertional activation of a promoterless thymidine kinase gene.
Herpes Simplex
INSM1 Promoter-Driven Adenoviral Herpes Simplex Virus Thymidine Kinase Cancer Gene Therapy for the Treatment of Primitive Neuroectodermal Tumors.
Herpes Simplex
Insulin-induced reactivation of an inactive herpes simplex thymidine kinase gene.
Herpes Simplex
Integrated homology modelling and X-ray study of herpes simplex virus I thymidine kinase: a case study.
Herpes Simplex
Integration and expression of a truncated simian virus 40 early gene fragment in mammalian cells.
Herpes Simplex
Integration site(s) of herpes simplex virus type 1 thymidine kinase gene and regional assignment of the gene for aminoacylase-1 in human chromosomes.
Herpes Simplex
Integration-free iPS cells engineered using human artificial chromosome vectors.
Herpes Simplex
Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.
Herpes Simplex
Interaction of cell and virus proteins with DNA sequences encompassing the promoter/regulatory and leader regions of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.
Herpes Simplex
Interaction of the mouse chromosomal protein HMG-I with the 3' ends of genes in vitro.
Herpes Simplex
Interaction of the recombinant herpes simplex virus type 1 thymidine kinase with thymidine and aciclovir: a kinetic study.
Herpes Simplex
Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22.
Herpes Simplex
Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide.
Herpes Simplex
Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells.
Herpes Simplex
Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.
Herpes Simplex
Intracellular localization and sustained prodrug cell killing activity of TAT-HSVTK fusion protein in hepatocelullar carcinoma cells.
Herpes Simplex
Intracellular localization of Herpes simplex virus type 1 thymidine kinase fused to different fluorescent proteins depends on choice of fluorescent tag.
Herpes Simplex
Intracerebral Administration of Autologous Mesenchymal Stem Cells as HSV-TK Gene Vehicle for Treatment of Glioblastoma Multiform: Safety and Feasibility Assessment.
Herpes Simplex
Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primates.
Herpes Simplex
Intrachromosomal homologous recombination in human cells which differ in nucleotide excision-repair capacity.
Herpes Simplex
Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response.
Herpes Simplex
Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain.
Herpes Simplex
Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system.
Herpes Simplex
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy.
Herpes Simplex
Introduction and expression of a fetal human globin gene in mouse fibroblasts.
Herpes Simplex
Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker.
Herpes Simplex
Introduction of cloned human papillomavirus 1a DNA into rat fibroblasts: integration, de novo methylation and absence of cellular morphological transformation.
Herpes Simplex
Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA.
Herpes Simplex
Introduction, rescue and expression of plasmid genes in mammalian cells and Escherichia coli.
Herpes Simplex
Intron 16 insertion of the angiotensin converting enzyme gene and transcriptional regulation.
Herpes Simplex
Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.
Herpes Simplex
Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone.
Herpes Simplex
Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
Herpes Simplex
Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase.
Herpes Simplex
Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo.
Herpes Simplex
Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.
Herpes Simplex
Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells.
Herpes Simplex
Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment.
Herpes Simplex
Iron(II) EDTA used to measure the helical twist along any DNA molecule.
Herpes Simplex
Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.
Herpes Simplex
Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors.
Herpes Simplex
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
Herpes Simplex
Isolation of a simian virus 40 T-antigen-positive, transformation-resistant cell line by indirect selection.
Herpes Simplex
Isolation of cis-acting vaccinia virus DNA fragments promoting the expression of herpes simplex virus thymidine kinase by recombinant viruses.
Herpes Simplex
Isolation of embryonal carcinoma cell lines that express integrated recombinant genes flanked by the Moloney murine leukemia virus long terminal repeat.
Herpes Simplex
Isozyme studies on the association of the herpes simplex virus type 1 thymidine kinase gene with human chromosomes in somatic cell hybrids.
Herpes Simplex
Killing effect of the herpes simplex virus thymidine kinase/ganciclovir enzyme/prodrug system on human nasopharyngeal carcinoma cells.
Herpes Simplex
Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase.
Herpes Simplex
Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.
Herpes Simplex
Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site.
Herpes Simplex
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine.
Herpes Simplex
Kinetics of cell death in T lymphocytes genetically modified with two novel suicide fusion genes.
Herpes Simplex
Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2.
Herpes Simplex
L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth.
Herpes Simplex
Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation.
Herpes Simplex
Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery.
Herpes Simplex
Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.
Herpes Simplex
Lack of stereospecificity of suid pseudorabies virus thymidine kinase.
Herpes Simplex
Large macromolecules can be introduced into cultured mammalian cells using erythrocyte membrane vesicles.
Herpes Simplex
Latency-associated transcript but not reactivatable virus is present in sensory ganglion neurons after inoculation of thymidine kinase-negative mutants of herpes simplex virus type 1.
Herpes Simplex
Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals.
Herpes Simplex
Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains.
Herpes Simplex
Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus.
Herpes Simplex
Left-handedly curved DNA regulates accessibility to cis-DNA elements in chromatin.
Herpes Simplex
Lentiviral vector conferring resistance to mycophenolate mofetil and sensitivity to ganciclovir for in vivo T-cell selection.
Herpes Simplex
Lentiviral vector mediated thymidine kinase expression in pluripotent stem cells enables removal of tumorigenic cells.
Herpes Simplex
Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.
Herpes Simplex
Lepidopteran cell variants resistant to 5-bromodeoxyuridine and their use for transfection of the HSV-TK gene.
Herpes Simplex
Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.
Herpes Simplex
Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.
Herpes Simplex
Linkage map of cotransfected viral DNA sequences in a mouse 3T3 cell line.
Herpes Simplex
Linking a cell-division gene and a suicide gene to define and improve cell therapy safety.
Herpes Simplex
Lipid-mediated protein delivery of suicide nucleoside kinases.
Herpes Simplex
Liposomal delivery of the herpes simplex virus thymidine kinase gene in glioma: improvement of cell sensitization to ganciclovir.
Herpes Simplex
Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats.
Herpes Simplex
Liposome vector containing biosurfactant-complexed DNA as herpes simplex virus thymidine kinase gene delivery system.
Herpes Simplex
Liposome-mediated gene therapy using HSV-TK/ganciclovir under the control of human PSA promoter in prostate cancer cells.
Herpes Simplex
Liquid-based iterative recombineering method tolerant to counter-selection escapes.
Herpes Simplex
Live cell vaccines expressing B7.1, monocyte chemoattractant protein 1 and granulocyte-macrophage colony stimulation factor derived from mouse HPV16-transformed cells.
Herpes Simplex
Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion.
Herpes Simplex
Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase.
Herpes Simplex
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Herpes Simplex
Local inflammation and devascularization--in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma.
Herpes Simplex
Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.
Herpes Simplex
Local regression of breast tumors following intramammary ganciclovir administration in double transgenic mice expressing neu oncogene and herpes simplex virus thymidine kinase.
Herpes Simplex
Localization in mouse-L-Cell chromosomal sites of transferred immunoglobulin genes.
Herpes Simplex
Localization of cis-acting sequences in the latency-related promoter of bovine herpesvirus 1 which are regulated by neuronal cell type factors and immediate-early genes.
Herpes Simplex
Localization of the thymidine kinase gene of herpes simplex virus type 2 (333).
Herpes Simplex
Localized adenovirus gene delivery using antiviral IgG complexation.
Herpes Simplex
Locating a nucleotide-binding site in the thymidine kinase of vaccinia virus and of herpes simplex virus by scoring triply aligned protein sequences.
Herpes Simplex
Location and cloning of the herpes simplex virus type 2 thymidine kinase gene.
Herpes Simplex
Location of sequences in polyomavirus DNA that are required for early gene expression in vivo and in vitro.
Herpes Simplex
Locoregional delivery of adenoviral vectors.
Herpes Simplex
Long inverted repeats are an at-risk motif for recombination in mammalian cells.
Herpes Simplex
Long term non-invasive imaging of embryonic stem cells using reporter genes.
Herpes Simplex
Long-term connexin-mediated bystander effect in highly tumorigenic human cells in vivo in herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Herpes Simplex
Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy.
Herpes Simplex
Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer.
Herpes Simplex
Long-term rat survival after malignant brain tumor regression by retroviral gene therapy.
Herpes Simplex
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.
Herpes Simplex
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.
Herpes Simplex
Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses.
Herpes Simplex
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
Herpes Simplex
Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance.
Herpes Simplex
Loss of ganciclovir sensitivity by exclusion of thymidine kinase gene from transplanted proinsulin-producing fibroblasts as a gene therapy model for diabetes.
Herpes Simplex
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Herpes Simplex
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Herpes Simplex
Low p16(INK4a) Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone.
Herpes Simplex
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma.
Herpes Simplex
Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.
Herpes Simplex
Luciferase assay to study the activity of a cloned promoter DNA fragment.
Herpes Simplex
LY294002 Enhances Expression of Proteins Encoded by Recombinant Replication-Defective Adenoviruses via mTOR- and Non-mTOR-Dependent Mechanisms.
Herpes Simplex
Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene.
Herpes Simplex
Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells.
Herpes Simplex
Mapping functional domains in the promoter region of the herpes thymidine kinase gene.
Herpes Simplex
Mapping of herpes simplex virus-1 VP22 functional domains for inter- and subcellular protein targeting.
Herpes Simplex
Mapping of the herpes simplex virus DNA sequences in three herpes simplex virus thymidine kinase-transformed cell lines.
Herpes Simplex
Mapping of the late promoter of simian virus 40.
Herpes Simplex
Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants.
Herpes Simplex
Massive apoptotic cell death in chemically induced rat urinary bladder carcinomas following in situ HSVtk electrogene transfer.
Herpes Simplex
Measuring herpes simplex virus thymidine kinase reporter gene expression in vitro.
Herpes Simplex
Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment.
Herpes Simplex
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
Herpes Simplex
Mechanism of resistance to acyclovir in thymidine kinase mutants from Herpes simplex virus type 1: a computational approach.
Herpes Simplex
Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Mechanisms in the transcriptional regulation of bradykinin B1 receptor gene expression. Identification of a minimum cell-type specific enhancer.
Herpes Simplex
Mechanisms of glucocorticoid hormone action.
Herpes Simplex
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Herpes Simplex
Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging.
Herpes Simplex
Metabolic fate of (E)-5-(2-bromovinyl)-2'-deoxyuridine in herpes simplex virus- and mock-infected cells.
Herpes Simplex
Metabolic suicide genes in gene therapy.
Herpes Simplex
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Herpes Simplex
Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells.
Herpes Simplex
Methodology and problems of protein-ligand docking: case study of dihydroorotate dehydrogenase, thymidine kinase, and phosphodiesterase 4.
Herpes Simplex
Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism.
Herpes Simplex
Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery.
Herpes Simplex
MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene.
Herpes Simplex
MicroPET imaging of prostate cancer in LNCAP-SR39TK-GFP mouse xenografts.
Herpes Simplex
Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma.
Herpes Simplex
Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter.
Herpes Simplex
Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor.
Herpes Simplex
Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors.
Herpes Simplex
Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas.
Herpes Simplex
Minicircles for a two-step blood biomarker and PET imaging early cancer detection strategy.
Herpes Simplex
Minimal transcriptional enhancer of simian virus 40 is a 74-base-pair sequence that has interacting domains.
Herpes Simplex
miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy.
Herpes Simplex
miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy.
Herpes Simplex
miR-145 is a potential biomarker for predicting clinical outcome in glioblastomas.
Herpes Simplex
Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay.
Herpes Simplex
Mitochondrial and herpesvirus-specific deoxypyrimidine kinases.
Herpes Simplex
Mitochondrial DNA damage induces apoptosis in senescent cells.
Herpes Simplex
Mitochondrial nucleic acids as internal standards for blot hybridization analyses.
Herpes Simplex
MLH1 deficiency enhances tumor cell sensitivity to ganciclovir.
Herpes Simplex
MLV/HIV-pseudotyped vectors: a new treatment option for cutaneous T cell lymphomas.
Herpes Simplex
Mobilization of plasmid pHSV106 from Escherichia coli HB101 in a laboratory-scale waste treatment facility.
Herpes Simplex
Mobilization of the genetically engineered plasmid pHSV106 from Escherichia coli HB101(pHSV106) to Enterobacter cloacae in drinking water.
Herpes Simplex
Mode of cell death associated with adenovirus-mediated suicide gene therapy in HNSCC tumor model.
Herpes Simplex
Modular structure of the beta-globin and the TK promoters.
Herpes Simplex
Modulation of transfected gene expression mediated by changes in chromatin structure.
Herpes Simplex
Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.
Herpes Simplex
Molecular analysis of a neurovirulent herpes simplex virus type 2 strain with reduced thymidine kinase activity.
Herpes Simplex
Molecular analysis of chromosome-mediated gene transfer.
Herpes Simplex
Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea.
Herpes Simplex
Molecular analysis of the human myeloperoxidase promoter region.
Herpes Simplex
Molecular approaches to chemo-radiotherapy.
Herpes Simplex
Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.
Herpes Simplex
Molecular characterization of a novel transcription factor that controls stromelysin expression.
Herpes Simplex
Molecular diagnosis and gene therapy in musculoskeletal tumors.
Herpes Simplex
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.
Herpes Simplex
Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography.
Herpes Simplex
Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.
Herpes Simplex
Molecular imaging of homodimeric protein-protein interactions in living subjects.
Herpes Simplex
Molecular imaging of human embryonic stem cells.
Herpes Simplex
Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo.
Herpes Simplex
Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence.
Herpes Simplex
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.
Herpes Simplex
Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Molecular modeling of the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.
Herpes Simplex
Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU.
Herpes Simplex
Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs.
Herpes Simplex
Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene.
Herpes Simplex
Monitoring Bone Marrow Stem Cells with a Reporter Gene System in Experimental Middle Cerebral Artery Occlusion Rat Models.
Herpes Simplex
Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates.
Herpes Simplex
Monitoring gene therapy with reporter gene imaging.
Herpes Simplex
Monitoring HSV-TK/ganciclovir cancer suicide gene therapy using CdTe/CdS core/shell quantum dots.
Herpes Simplex
Monitoring of bystander effect of herpes simplex virus thymidine kinase/acyclovir system using fluorescence resonance energy transfer technique.
Herpes Simplex
Monitoring of developing graft-versus-host disease mediated by herpes simplex virus thymidine kinase gene-transduced T cells.
Herpes Simplex
Monitoring of gliomas in vivo by diffusion MRI and (1)H MRS during gene therapy-induced apoptosis: interrelationships between water diffusion and mobile lipids.
Herpes Simplex
Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography.
Herpes Simplex
Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors.
Herpes Simplex
Monitoring the efficacy of adoptively transferred prostate cancer-targeted human T lymphocytes with PET and bioluminescence imaging.
Herpes Simplex
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging.
Herpes Simplex
Monoclonal antibodies to herpes simplex virus thymidine kinase.
Herpes Simplex
Morphological transformation by DNA fragments of human herpesviruses: evidence for two distinct transforming regions in herpes simplex virus types 1 and 2 and lack of correlation with biochemical transfer of the thymidine kinase gene.
Herpes Simplex
Mouse L cells express a molecular complex carrying the human epitopes recognized by monoclonal antibodies 44D7 and 44H7 after DNA-mediated gene transfer.
Herpes Simplex
Mouse mammary tumor virus mediated transfer and expression of neomycin resistance to infected cultured cells.
Herpes Simplex
Mouse model for ablation of proliferating microglia in acute CNS injuries.
Herpes Simplex
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma.
Herpes Simplex
Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells.
Herpes Simplex
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Herpes Simplex
Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging.
Herpes Simplex
Multimodality molecular imaging to monitor transplanted stem cells for the treatment of ischemic heart disease.
Herpes Simplex
Multiple regulatory elements in the intergenic region between the alpha-fetoprotein and albumin genes.
Herpes Simplex
Multiple sequence elements are involved in RNA 3' end formation in spleen necrosis virus.
Herpes Simplex
Multiple sets of adjacent mu E1 and oct-1 binding sites upstream of the pseudorabies virus immediate-early gene promoter.
Herpes Simplex
Multiple transduction as a means of preserving ganciclovir chemosensitivity in sarcoma cells carrying retrovirally transduced herpes thymidine kinase genes.
Herpes Simplex
Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector.
Herpes Simplex
Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir.
Herpes Simplex
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Herpes Simplex
Muscle-specific activity of the skeletal troponin I promoter requires interaction between upstream regulatory sequences and elements contained within the first transcribed exon.
Herpes Simplex
Mutant of herpes simplex virus type 1 conditionally able to transform thymidine kinaseless L cells to a tk+ phenotype.
Herpes Simplex
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies.
Herpes Simplex
Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells.
Herpes Simplex
Mutation spectra of herpes simplex virus type 1 thymidine kinase mutants.
Herpes Simplex
Mutational analyses of dinucleotide and tetranucleotide microsatellites in Escherichia coli: influence of sequence on expansion mutagenesis.
Herpes Simplex
Mutational specificities of 1'-acetoxysafrole, N-benzoyloxy-N-methyl-4-aminoazobenzene, and ethyl methanesulfonate in human cells.
Herpes Simplex
Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.
Herpes Simplex
Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene.
Herpes Simplex
N-ethyl-N-nitrosourea induces A:T to C:G transversion mutations as well as transition mutations in SOS-induced Escherichia coli.
Herpes Simplex
N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Herpes Simplex
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.
Herpes Simplex
Negative selection of herpes simplex virus thymidine kinase in Toxoplasma gondii.
Herpes Simplex
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination.
Herpes Simplex
Negative selection using thymidine kinase increases the efficiency of recovery of transformants with targeted genes in the filamentous fungus Leptosphaeria maculans.
Herpes Simplex
Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
Herpes Simplex
Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models.
Herpes Simplex
NeoR-based transduced T lymphocytes detected by real-time quantitative polymerase chain reaction.
Herpes Simplex
Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.
Herpes Simplex
Neural stem cell-based dual suicide gene delivery for metastatic brain tumors.
Herpes Simplex
Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
Herpes Simplex
Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat).
Herpes Simplex
Neurovirulence and latency of drug-resistant clinical herpes simplex viruses in animal models.
Herpes Simplex
Neurovirulence of an herpes simplex type 1 thymidine kinase negative mutant determined by virus biochemical defect and host immune system in mice. Brief report.
Herpes Simplex
Neurovirulence of herpes simplex virus type 1 depends on age in mice and thymidine kinase expression.
Herpes Simplex
New culture technique of human eliminable feeder-assisted target cell sheet production.
Herpes Simplex
New Plasmids for Fusarium Transformation Allowing Positive-Negative Selection and Efficient Cre-loxP Mediated Marker Recycling.
Herpes Simplex
New positive/negative selectable markers for mammalian cells on the basis of Blasticidin deaminase-thymidine kinase fusions.
Herpes Simplex
New vectors for simplified construction of BrdU-Incorporating strains of Saccharomyces cerevisiae.
Herpes Simplex
NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression.
Herpes Simplex
NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer.
Herpes Simplex
Non myeloablative "mini transplants".
Herpes Simplex
Non-integrating lentiviral vectors for specific killing of Epstein-Barr virus nuclear antigen 1-positive B cell lymphoma cells.
Herpes Simplex
Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter gene.
Herpes Simplex
Non-invasive imaging of reporter genes.
Herpes Simplex
Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir.
Herpes Simplex
Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model.
Herpes Simplex
Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.
Herpes Simplex
Non-Small-Cell Lung Cancer: Feasibility of Intratumoral Radiofrequency Hyperthermia-enhanced Herpes Simplex Virus Thymidine Kinase Gene Therapy.
Herpes Simplex
Non-traumatic acquisition of herpes simplex virus infection through the eye.
Herpes Simplex
Noninvasive and Local Delivery of Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase to Treat Glioma Through Focused Ultrasound-Induced Blood-Brain Barrier Opening in Rats.
Herpes Simplex
Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma.
Herpes Simplex
Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter genes in living mice.
Herpes Simplex
Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heart.
Herpes Simplex
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Herpes Simplex
Noninvasive imaging of protein-protein interactions in living animals.
Herpes Simplex
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Herpes Simplex
Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus.
Herpes Simplex
Nonmyeloablative immunosuppressive regimen prolongs In vivo persistence of gene-modified autologous T cells in a nonhuman primate model.
Herpes Simplex
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.
Herpes Simplex
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Herpes Simplex
Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma.
Herpes Simplex
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Herpes Simplex
Novel 6-azapyrimidine-2'-deoxy-4'-thionucleosides: synthesis, biological evaluation and conformational analysis.
Herpes Simplex
Novel codon utilization within the vaccinia virus thymidine kinase gene.
Herpes Simplex
Novel estrogenic action of the pesticide residue beta-hexachlorocyclohexane in human breast cancer cells.
Herpes Simplex
Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
Herpes Simplex
Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer.
Herpes Simplex
Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient.
Herpes Simplex
Novel radiosynthesis of PET HSV-tk gene reporter probes [18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques.
Herpes Simplex
Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.
Herpes Simplex
Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system.
Herpes Simplex
Novel use of synthetic oligonucleotide insertion mutants for the study of homologous recombination in mammalian cells.
Herpes Simplex
Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?
Herpes Simplex
Nuclease footprint analyses of the interactions between RNase P ribozyme and a model mRNA substrate.
Herpes Simplex
Nucleoside analogs as non-substrate inhibitors of herpes simplex viruses thymidine kinase.
Herpes Simplex
Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.
Herpes Simplex
Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.
Herpes Simplex
Nucleosomal packaging of the thymidine kinase gene of herpes simplex virus transferred into mouse cells: an actively expressed single-copy gene.
Herpes Simplex
Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir.
Herpes Simplex
Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thymidine kinase gene.
Herpes Simplex
Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene.
Herpes Simplex
Nucleotide sequence of the thymidine kinase gene of a new strain of herpes simplex virus type 1.
Herpes Simplex
Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.
Herpes Simplex
Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus.
Herpes Simplex
Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes.
Herpes Simplex
Nucleotide sequences responsible for the thermal inducibility of the Drosophila small heat-shock protein genes in monkey COS cells.
Herpes Simplex
O6-methylguanine induces intrachromosomal homologous recombination in human cells.
Herpes Simplex
Occurrence of antibodies against herpes simplex virus thymidine kinase in human sera.
Herpes Simplex
Ocular gene therapy: experimental studies and clinical possibilities.
Herpes Simplex
Oligonucleotide-directed mutagenesis and subsequent expression of the corresponding recombinant proteins without changing the bacterial vector system.
Herpes Simplex
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.
Herpes Simplex
Oncolytic Gene Therapy Combined with Double Suicide Genes for Human Bile Duct Cancer in Nude Mouse Models.
Herpes Simplex
Oncoselective parvoviral vector-mediated gene therapy of cancer.
Herpes Simplex
One-Stage Positron Emission Tomography and Magnetic Resonance Imaging to Assess Mesenchymal Stem Cell Survival in a Canine Model of Intervertebral Disc Degeneration.
Herpes Simplex
Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.
Herpes Simplex
Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice.
Herpes Simplex
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Herpes Simplex
Optimized assay for thymidine kinase and its application to the detection of antibodies against herpes simplex virus type 1- and 2-induced thymidine kinase.
Herpes Simplex
Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences.
Herpes Simplex
Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants.
Herpes Simplex
Optimizing suicide gene therapy for head and neck cancer.
Herpes Simplex
Organized Neurogenic-Niche-Like Pinwheel Structures Discovered in Spinal Cord Tissue-Derived Neurospheres.
Herpes Simplex
Origins of Suicide Gene Therapy.
Herpes Simplex
Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models.
Herpes Simplex
Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer.
Herpes Simplex
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Herpes Simplex
Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene.
Herpes Simplex
Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene.
Herpes Simplex
Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model.
Herpes Simplex
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
Herpes Simplex
Overexpression of a heterologous thymidine kinase delays apoptosis induced by factor deprivation and inhibitors of deoxynucleotide metabolism.
Herpes Simplex
Overexpression of c-fos increases recombination frequency in human osteosarcoma cells.
Herpes Simplex
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Herpes Simplex
Overproduction of the protein product of a nonselected foreign gene carried by an adenovirus vector.
Herpes Simplex
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Herpes Simplex
P21-driven multifusion gene system for evaluating the efficacy of histone deacetylase inhibitors by in vivo molecular imaging and for transcription targeting therapy of cancer mediated by histone deacetylase inhibitor.
Herpes Simplex
P53-dependent cell-killing by selective repression of thymidine kinase and reduced prodrug activation.
Herpes Simplex
Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Papers to appear in forthcoming issues
Herpes Simplex
Partial regression, yet incomplete eradication of mammary tumors in transgenic mice by retrovirally mediated HSVtk transfer 'in vivo'.
Herpes Simplex
Partial substitution of the functions of the herpes simplex virus 1 U(L)13 gene by the human cytomegalovirus U(L)97 gene.
Herpes Simplex
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.
Herpes Simplex
Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.
Herpes Simplex
PEG-PBLG nanoparticle-mediated HSV-TK/GCV gene therapy for oral squamous cell carcinoma.
Herpes Simplex
Penciclovir is a potent inhibitor of feline herpesvirus-1 with susceptibility determined at the level of virus-encoded thymidine kinase.
Herpes Simplex
Percutaneous gene therapy using recombinant adenoviruses encoding human herpes simplex virus thymidine kinase, human PAI-1, and human NOS3 in balloon-injured porcine coronary arteries.
Herpes Simplex
Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis [corrected]
Herpes Simplex
Persistent herpes simplex virus infection and mechanisms of virus drug resistance.
Herpes Simplex
PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts.
Herpes Simplex
PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [18F]FHBG.
Herpes Simplex
PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers.
Herpes Simplex
PET Imaging of Oncolytic VSV Expressing the Mutant HSV-1 Thymidine Kinase Transgene in a Preclinical HCC Rat Model.
Herpes Simplex
PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene.
Herpes Simplex
PET reporter gene imaging and ganciclovir-mediated ablation of chimeric antigen receptor T-cells in solid tumors.
Herpes Simplex
Phage particle-mediated gene transfer to cultured mammalian cells.
Herpes Simplex
Pharmacokinetic considerations regarding non-viral cancer gene therapy.
Herpes Simplex
Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.
Herpes Simplex
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Herpes Simplex
Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside.
Herpes Simplex
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors.
Herpes Simplex
Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer.
Herpes Simplex
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Herpes Simplex
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer.
Herpes Simplex
Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma.
Herpes Simplex
Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir.
Herpes Simplex
Phenotypic switching in cells transformed with the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Phenotypic variation associated with molecular alterations at a cluster of thymidine kinase genes.
Herpes Simplex
Phosphorylation and cytotoxicity of therapeutic nucleoside analogues: a comparison of alpha and gamma herpesvirus thymidine kinase suicide genes.
Herpes Simplex
Phosphorylation of 5-iodo-5'-amino-2',5',dideoxyuridine by herpes simplex virus type 1 encoded thymidine kinase.
Herpes Simplex
Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase.
Herpes Simplex
Phosphorylation of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes viruses.
Herpes Simplex
Phosphorylation of the enantiomers of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase.
Herpes Simplex
Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir.
Herpes Simplex
Picosecond-hetero-FRET microscopy to probe protein-protein interactions in live cells.
Herpes Simplex
Pituitary and ovarian expression of the endogenous follicle-stimulating hormone (FSH) subunit genes and an FSH beta-subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic mice; specific partial ablation of FSH-producing cells by antiherpes treatment.
Herpes Simplex
Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates.
Herpes Simplex
Plasma and CSF pharmacokinetics of ganciclovir in nonhuman primates.
Herpes Simplex
Plasmid DNA mediated transfer of the herpes simplex virus thymidine kinase gene to a new bromodeoxyuridine resistant variant of human primary lung carcinoma cells.
Herpes Simplex
Plasmid rescue - a tool for reproducible recovery of genes from transfected mammalian cells?
Herpes Simplex
Plasmidial maintenance in rodent fibroblasts of a BPV1-pBR322 shuttle vector without immediately apparent oncogenic transformation of the recipient cells.
Herpes Simplex
Plasmids containing mouse rDNA do not recombine with cellular ribosomal genes when introduced into cultured mouse cells.
Herpes Simplex
Plasmids expressing the Herpes simplex virus thymidine kinase gene in mammalian and bacterial cells.
Herpes Simplex
Platelet-derived growth factor A-chain gene transcription is mediated by positive and negative regulatory regions in the promoter.
Herpes Simplex
Pleiotropic expression of heterologous cytokine/receptor genes in HTLV-1 associated diseases: candidate TRS for chimeric gene therapy.
Herpes Simplex
PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins.
Herpes Simplex
Polyadenylation of the Xenopus beta 1 globin mRNA at a downstream minor site in the absence of the major site and utilization of an AAUACA polyadenylation signal.
Herpes Simplex
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
Herpes Simplex
Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.
Herpes Simplex
Polyethylenimine-mediated suicide gene transfer induces a therapeutic effect for hepatocellular carcinoma in vivo by using an Epstein-Barr virus-based plasmid vector.
Herpes Simplex
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
Herpes Simplex
Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy.
Herpes Simplex
Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains.
Herpes Simplex
Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences.
Herpes Simplex
Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK.
Herpes Simplex
Positron emission tomography imaging of cardiac reporter gene expression in living rats.
Herpes Simplex
Positron emission tomography imaging of conditional gene activation in the heart.
Herpes Simplex
Positron emission tomography of herpes simplex virus 1 oncolysis.
Herpes Simplex
Positron emission tomography: measurement of transgene expression.
Herpes Simplex
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Herpes Simplex
Positron-emission tomography reporter gene expression imaging in rat myocardium.
Herpes Simplex
Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus.
Herpes Simplex
Possible roles of the 3'-flanking sequences of the human activin beta A subunit gene in its expression.
Herpes Simplex
Post-translational regulation of gene expression using the ATF4 oxygen-dependent degradation domain for hypoxia-specific gene therapy.
Herpes Simplex
Potent anti-tumor activity of telomerase-dependent and HSV-TK armed oncolytic adenovirus for non-small cell lung cancer in vitro and in vivo.
Herpes Simplex
Potent bystander effect in suicide gene therapy using neural stem cells transduced with herpes simplex virus thymidine kinase gene.
Herpes Simplex
Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine.
Herpes Simplex
Potential of gene therapy for the treatment of pituitary tumors.
Herpes Simplex
Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin.
Herpes Simplex
Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy.
Herpes Simplex
Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes.
Herpes Simplex
Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma.
Herpes Simplex
Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase.
Herpes Simplex
Preclinical evaluation of the penciclovir analog 9-(4-[(18)F]fluoro-3-hydroxymethylbutyl)guanine for in vivo measurement of suicide gene expression with PET.
Herpes Simplex
Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells.
Herpes Simplex
Preclinical Safety Evaluation of 18F-FHBG: A PET Reporter Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1-tk) or Mutant HSV1-sr39tk's Expression.
Herpes Simplex
Prediction of the binding mode of N2-phenylguanine derivative inhibitors to herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine.
Herpes Simplex
Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector.
Herpes Simplex
Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir.
Herpes Simplex
Preliminary in vitro efficacy and toxicities studies of the herpes simplex thymidine kinase gene system for the treatment of breast cancer.
Herpes Simplex
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Herpes Simplex
Prenatal exposure to thyroid hormone is necessary for normal postnatal development of murine heart and lungs.
Herpes Simplex
Preparation and biological evaluation of 2-amino-6-[18F]fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-[18F]FPCV) as a novel PET probe for imaging HSV1-tk reporter gene expression.
Herpes Simplex
Preparation of a "functional library" of African green monkey DNA fragments which substitute for the processing/polyadenylation signal in the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Presence of antibody against herpes simplex virus-specified thymidine kinase and deoxyribonuclease in human sera.
Herpes Simplex
Presence of transcription regulatory elements within an intron of the virus-inducible murine TIMP gene.
Herpes Simplex
Preservation of the bystander cytocidal effect of irradiated herpes simplex virus thymidine kinase (HSV-tk) modified tumor cells.
Herpes Simplex
Prevention of graft-versus-host disease in mice using a suicide gene expressed in T lymphocytes.
Herpes Simplex
Prevention of hepatitis C virus infection by adoptive allogeneic immunotherapy using suicide gene-modified lymphocytes: an in vitro proof-of-concept.
Herpes Simplex
Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.
Herpes Simplex
Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer.
Herpes Simplex
Processing of herpes simplex virus proteins and evidence that translation of thymidine kinase mRNA is initiated at three separate AUG codons.
Herpes Simplex
Prodrug activation gene therapy and external beam irradiation in the treatment of prostate cancer.
Herpes Simplex
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Herpes Simplex
Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".
Herpes Simplex
Prodrugs in genetic chemoradiotherapy.
Herpes Simplex
Prodrugs of herpes simplex thymidine kinase inhibitors.
Herpes Simplex
Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer.
Herpes Simplex
Production and culture of HSVtk transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition.
Herpes Simplex
Production and first-in-man use of T cells engineered to express a HSVTK-CD34 sort-suicide gene.
Herpes Simplex
Production of a heterozygous mutant cell line by homologous recombination (single knockout).
Herpes Simplex
Production of a T-antigen-related protein in mammalian cells after stable transformation with a cloned SV40 gene fragment.
Herpes Simplex
Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues.
Herpes Simplex
Production of human glucocerebrosidase in mice after retroviral gene transfer into multipotential hematopoietic progenitor cells.
Herpes Simplex
Prognostic utility of gene therapy with herpes simplex virus thymidine kinase for patients with high-grade malignant gliomas: a systematic review and meta analysis.
Herpes Simplex
Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University.
Herpes Simplex
Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
Herpes Simplex
Prolactin and growth hormone stimulation of lactation in mice requires thyroid hormones.
Herpes Simplex
Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes.
Herpes Simplex
Promoter-glutathione S-transferase Ya cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells.
Herpes Simplex
Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines.
Herpes Simplex
Properties of a novel thymidine kinase induced by an acyclovir-resistant herpes simplex virus type 1 mutant.
Herpes Simplex
Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thymidine Kinase Gene: Mechanisms of Reversion to a Thymidine Kinase-Negative Phenotype.
Herpes Simplex
Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase.
Herpes Simplex
ProPose: steered virtual screening by simultaneous protein-ligand docking and ligand-ligand alignment.
Herpes Simplex
Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models.
Herpes Simplex
Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model.
Herpes Simplex
Protecting against wayward human induced pluripotent stem cells with a suicide gene.
Herpes Simplex
Protection against Leishmania major challenge infection in mice vaccinated with live recombinant parasites expressing a cytotoxic gene.
Herpes Simplex
Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect.
Herpes Simplex
Proteins containing only half of the coding information of early region 1b of adenovirus are functional in human cells transformed with the herpes simplex virus type 1 thymidine kinase gene and adenovirus type 2 DNA.
Herpes Simplex
Proteolytic mapping of the thymidine/thymidylate binding site of herpes simplex virus type 1 thymidine kinase: a general photoaffinity labeling method for identifying active-site peptides.
Herpes Simplex
Pseudotyped retrovectors for tumor-specific delivery of toxic suicide genes.
Herpes Simplex
Psi- vectors: murine leukemia virus-based self-inactivating and self-activating retroviral vectors.
Herpes Simplex
Purification and characterization of herpes simplex virus (type 1) thymidine kinase produced in Escherichia coli by a high efficiency expression plasmid utilizing a lambda PL promoter and cI857 temperature-sensitive repressor.
Herpes Simplex
Purification and crystallization of thymidine kinase from herpes simplex virus type 1.
Herpes Simplex
Purification and photoaffinity labeling of herpes simplex virus type-1 thymidine kinase.
Herpes Simplex
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Herpes Simplex
Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms.
Herpes Simplex
Purified herpes simplex virus thymidine kinase retroviral particles: III. Characterization of bystander killing mechanisms in transfected tumor cells.
Herpes Simplex
Pyrimidine acyclic nucleosides, 1-[(2-Hydroxyethoxy)methyl]pyrimidines as candidate antivirals.
Herpes Simplex
Pyrimidine acyclic nucleosides. 5-Substituted 1-[(2-aminoethoxy)methyl]uracils as candidate antivirals.
Herpes Simplex
QSAR and molecular graphics analysis of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
Herpes Simplex
QSAR of N2-phenylguanidines as inhibitors of herpes simplex virus-1 thymidine kinase.
Herpes Simplex
Quantification and Analysis of Thymidine Kinase Expression from Acyclovir-Resistant G-String Insertion and Deletion Mutants in Herpes Simplex Virus-Infected Cells.
Herpes Simplex
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.
Herpes Simplex
Quantitation of cell number by a positron emission tomography reporter gene strategy.
Herpes Simplex
Quantitation of pulmonary transgene expression with PET imaging.
Herpes Simplex
Quantitative 1H nuclear magnetic resonance diffusion spectroscopy of BT4C rat glioma during thymidine kinase-mediated gene therapy in vivo: identification of apoptotic response.
Herpes Simplex
Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring gamma-retrovirus-encoded hsvtk suicide genes.
Herpes Simplex
Quantitative analysis of gene suppression in integrated retrovirus vectors.
Herpes Simplex
Quantitative kinetics of [124I]FIAU in cat and man.
Herpes Simplex
Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.
Herpes Simplex
Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA.
Herpes Simplex
Radiochemotherapy of hepatocarcinoma via lentivirus-mediated transfer of human sodium iodide symporter gene and herpes simplex virus thymidine kinase gene.
Herpes Simplex
Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes.
Herpes Simplex
Radiopharmaceuticals to monitor gene transfer.
Herpes Simplex
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Herpes Simplex
Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus.
Herpes Simplex
Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion.
Herpes Simplex
Rapid and liquid-based selection of genetic switches using nucleoside kinase fused with aminoglycoside phosphotransferase.
Herpes Simplex
Rapid and reproducible radiosynthesis of [18F] FHBG.
Herpes Simplex
Rapid phenotypic characterization method for herpes simplex virus and Varicella-Zoster virus thymidine kinases to screen for acyclovir-resistant viral infection.
Herpes Simplex
Rapid Regulation of Human Mesenchymal Stem Cell Proliferation Using Inducible Caspase-9 Suicide Gene for Safe Cell-Based Therapy.
Herpes Simplex
Rapid selection of antigen-specific T lymphocytes by retroviral transduction.
Herpes Simplex
Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development.
Herpes Simplex
Rapid typing of herpes simplex virus based on immunological specificity of viral thymidine kinase and typing according to sensitivity to iododeoxyuridine.
Herpes Simplex
Rat adenocarcinoma cell line infected with an adenovirus carrying a novel herpes-simplex virus-thymidine kinase suicide gene construct dies by apoptosis upon treatment with ganciclovir.
Herpes Simplex
Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment.
Herpes Simplex
Rational design of a triple reporter gene for multimodality molecular imaging.
Herpes Simplex
Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene.
Herpes Simplex
Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.
Herpes Simplex
Real-time visualizing and tracing of HSV-TK/GCV suicide gene therapy by near-infrared fluorescent quantum dots.
Herpes Simplex
Rearrangements of microinjected recombinant DNA in the genome of transgenic mice.
Herpes Simplex
recA-dependent and recA-independent N-ethyl-N-nitrosourea mutagenesis at a plasmid-encoded herpes simplex virus thymidine kinase gene in Escherichia coli.
Herpes Simplex
Recent advances in experimental molecular therapeutics for malignant gliomas.
Herpes Simplex
Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancer.
Herpes Simplex
Receptor-mediated gene delivery using the Fab fragments of anti-epidermal growth factor receptor antibodies: improved immunogene approach.
Herpes Simplex
Recognition by xenogeneic cytotoxic T lymphocytes of cells expressing HLA-A2 or HLA-B7 after DNA-mediated gene transfer.
Herpes Simplex
Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility.
Herpes Simplex
Recombinant interferon alpha2a synergistically enhances ganciclovir-mediated tumor cell killing in the herpes simplex virus thymidine kinase system.
Herpes Simplex
Recombination during gene transfer into mouse cells can restore the function of deleted genes.
Herpes Simplex
Recombination events in Neurospora crassa may cross a translocation breakpoint by a template-switching mechanism.
Herpes Simplex
Recovery of a hybrid vector, derived from bovine papilloma virus DNA, pBR322 and the HSV tk gene, by bacterial transformation with extrachromosomal DNA from transfected rodent cells.
Herpes Simplex
Recovery of a latent HSV-1 thymidine kinase negative strain following iontophoresis and co-cultivation in the ocularly-infected rabbit model.
Herpes Simplex
Recovery of myelin after induction of oligodendrocyte cell death in postnatal brain.
Herpes Simplex
Recovery of recombinant bacterial plasmids from E. coli transformed with DNA from microinjected mouse cells.
Herpes Simplex
Rectal immunization generates protective immunity in the female genital tract against herpes simplex virus type 2 infection: Relative importance of myeloid differentiation factor 88.
Herpes Simplex
Recurrent aciclovir-resistant herpes simplex in a child with Wiskott-Aldrich syndrome.
Herpes Simplex
Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis?
Herpes Simplex
Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.
Herpes Simplex
Reduced graft-versus-host disease-inducing capacity of T cells after activation, culturing, and magnetic cell sorting selection in an allogeneic bone marrow transplantation model in rats.
Herpes Simplex
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.
Herpes Simplex
Refined human artificial chromosome vectors for gene therapy and animal transgenesis.
Herpes Simplex
Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.
Herpes Simplex
Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
Herpes Simplex
Regulated expression of a transfected human cardiac actin gene during differentiation of multipotential murine embryonal carcinoma cells.
Herpes Simplex
Regulated expression of stably transfected herpes simplex virus thymidine kinase genes in continuous cell lines expressing a temperature-sensitive mutant form of the immediate-early protein ICP4.
Herpes Simplex
Regulated expression of the human beta-globin gene family in murine erythroleukaemia cells.
Herpes Simplex
Regulated high-level expression of the Herpes simplex type I thymidine kinase gene in Escherichia coli.
Herpes Simplex
Regulated Mesenchymal Stem Cells Mediated Colon Cancer Therapy Assessed by Reporter Gene Based Optical Imaging.
Herpes Simplex
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.
Herpes Simplex
Regulation of cellular genes transduced by herpes simplex virus.
Herpes Simplex
Regulation of function of the murine luteinizing hormone receptor promoter by cis- and trans-acting elements in mouse Leydig tumor cells.
Herpes Simplex
Regulation of herpes simplex virus 1 genes: alpha gene sequence requirements for transient induction of indicator genes regulated by beta or late (gamma 2) promoters.
Herpes Simplex
Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir.
Herpes Simplex
Regulation of herpes simplex virus type 1 thymidine kinase gene expression by thyroid hormone receptor in cultured neuronal cells.
Herpes Simplex
Regulation of herpes simplex virus-induced thymidine kinase.
Herpes Simplex
Regulation of herpesvirus thymidine kinase activity in LM(TK) cells transformed by ultraviolet light-irradiated herpes simplex virus.
Herpes Simplex
Regulation of HSVtk gene by endogenous microRNA-122a in liver cell lines as suicide gene therapy.
Herpes Simplex
Regulation of indoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-gamma. Upstream control region discriminates between interferon-gamma and interferon-alpha.
Herpes Simplex
Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Regulation of proliferation and functioning of transplanted cells by using herpes simplex virus thymidine kinase gene in mice.
Herpes Simplex
Regulation of recombinant human granulocyte colony-stimulation factor production using herpes simplex virus 1 thymidine kinase gene.
Herpes Simplex
Regulation of the herpes simplex virus gene for thymidine kinase in clonal derivatives of transformed mouse L-cells.
Herpes Simplex
Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle.
Herpes Simplex
Regulation of the neural-specific gene VGF in PC12 cells. Identification of transcription factors interacting with NGF-responsive elements.
Herpes Simplex
Regulation of type II renal Na+-dependent inorganic phosphate transporters by 1,25-dihydroxyvitamin D3. Identification of a vitamin D-responsive element in the human NAPi-3 gene.
Herpes Simplex
Regulation of tyrosinase expression and activity in cultured human retinal pigment epithelial cells.
Herpes Simplex
Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines.
Herpes Simplex
Release of the p53-induced repression on thymidine kinase promoter by single p53-binding sequence.
Herpes Simplex
Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains.
Herpes Simplex
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy.
Herpes Simplex
Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics.
Herpes Simplex
Repair of a specific double-strand break generated within a mammalian chromosome by yeast endonuclease I-SceI.
Herpes Simplex
Repetitive imaging of reporter gene expression in the lung.
Herpes Simplex
Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU.
Herpes Simplex
Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy.
Herpes Simplex
Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts.
Herpes Simplex
Replication and virulence of pseudorabies virus mutants lacking glycoprotein gX.
Herpes Simplex
Replication fidelity of the supF gene integrated in the thymidine kinase locus of herpes simplex virus type 1.
Herpes Simplex
Replication inhibition by nucleoside analogues of a recombinant Autographa californica multicapsid nuclear polyhedrosis virus harboring the herpes thymidine kinase gene driven by the IE-1(0) promoter: a new way to select recombinant baculoviruses.
Herpes Simplex
Replication of HSV-1 in murine peritoneal macrophages: comparison of various virus strains with different properties.
Herpes Simplex
Replication of thymidine kinase deficient herpes simplex virus type 1 in neuronal cell culture: infection of the PC 12 cell.
Herpes Simplex
Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.
Herpes Simplex
Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer.
Herpes Simplex
Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment.
Herpes Simplex
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.
Herpes Simplex
Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase.
Herpes Simplex
Rescue of a tk-plasmid from transgenic mice reveals its episomal transmission.
Herpes Simplex
Rescue of transfected genes from mammalian cells by functional selection in Escherichia coli.
Herpes Simplex
Residual expression of reporter genes in constructs mimicking HIV genome organization.
Herpes Simplex
Resistance developing after long-term ganciclovir prodrug treatment in a preclinical model of NSCLC.
Herpes Simplex
Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.
Herpes Simplex
Resistance of herpes simplex virus type 1 to acyclovir: thymidine kinase gene mutagenesis study.
Herpes Simplex
Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity.
Herpes Simplex
Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.
Herpes Simplex
Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.
Herpes Simplex
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.
Herpes Simplex
Retinoic acid stimulates transcriptional activity from the alkaline phosphatase promoter in the immortalized rat calvarial cell line, RCT-1.
Herpes Simplex
Retrovector encoding a green fluorescent protein-herpes simplex virus thymidine kinase fusion protein serves as a versatile suicide/reporter for cell and gene therapy applications.
Herpes Simplex
Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions.
Herpes Simplex
Retroviral suicide vector does not inhibit neointimal growth in a porcine coronary model of restenosis.
Herpes Simplex
Retroviral transfer of herpes simplex thymidine kinase gene into glioma cells causes targeting of gancyclovir cytotoxic effect.
Herpes Simplex
Retroviral transfer of herpes simplex virus-thymidine kinase and beta-galactosidase genes into U937 cells with bicistronic vector.
Herpes Simplex
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Herpes Simplex
Retroviral vector gene expression in F9 embryonal carcinoma cells.
Herpes Simplex
Retroviral vector-mediated gene transfer into keratocytes in vitro and in vivo.
Herpes Simplex
Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells.
Herpes Simplex
Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene.
Herpes Simplex
Retrovirus long terminal repeats activate expression of coding sequences for the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Retrovirus mediated gene transduction of human T-cell subsets.
Herpes Simplex
Retrovirus transduction: segregation of the viral transforming function and the herpes simplex virus tk gene in infectious Friend spleen focus-forming virus thymidine kinase vectors.
Herpes Simplex
Retrovirus-mediated gene therapy for hepatocellular carcinoma with reversely oriented therapeutic gene expression regulated by alpha-fetoprotein enhancer/promoter.
Herpes Simplex
Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human alpha-fetoprotein enhancer directly linked to its promoter.
Herpes Simplex
Retrovirus-mediated gene therapy for human hepatocellular carcinoma transplanted in athymic mice.
Herpes Simplex
Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire.
Herpes Simplex
Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma.
Herpes Simplex
Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo.
Herpes Simplex
Retrovirus-mediated herpes simplex virus thymidine kinase gene transfer in pancreatic cancer cell lines: an incomplete antitumor effect.
Herpes Simplex
Retrovirus-mediated in vivo gene therapy using the herpes simplex virus thymidine kinase gene against carcinomatous peritonitis.
Herpes Simplex
Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: feasibility in prevention of proliferative vitreoretinopathy.
Herpes Simplex
Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.
Herpes Simplex
Retrovirus-mediated transfer of the herpes simplex type I thymidine kinase gene in alloreactive T lymphocytes.
Herpes Simplex
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: implications for gene therapy.
Herpes Simplex
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and enhanced green fluorescence protein genes in primary T lymphocytes.
Herpes Simplex
Retroviruses and DNA: gene therapy for brain tumours.
Herpes Simplex
Reversibly immortalized hepatic progenitor cell line containing double suicide genes.
Herpes Simplex
Reversion of mutations in the thymidine kinase gene in herpes simplex viruses resistant to phosphonoacetate.
Herpes Simplex
Rhabdomyosarcoma-specific expression of the herpes simplex virus thymidine kinase gene confers sensitivity to ganciclovir.
Herpes Simplex
Ribozyme-mediated selective killing of cancer cells expressing carcinoembryonic antigen RNA by targeted trans-splicing.
Herpes Simplex
RNase P ribozymes for the studies and treatment of human cytomegalovirus infections.
Herpes Simplex
RNase P ribozymes selected in vitro to cleave a viral mRNA effectively inhibit its expression in cell culture.
Herpes Simplex
Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase.
Herpes Simplex
Role of genotypic analysis of the thymidine kinase gene of herpes simplex virus for determination of neurovirulence and resistance to acyclovir.
Herpes Simplex
Role of herpes simplex virus thymidine kinase expression in viral pathogenesis and latency.
Herpes Simplex
Role of the viral and cellular encoded thymidine kinase in the repair of UV-irradiated herpes simplex virus.
Herpes Simplex
Rostro-caudal maturation of glial cells in the accessory olfactory system during development: involvement in outgrowth of GnRH neurites.
Herpes Simplex
S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase.
Herpes Simplex
Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer.
Herpes Simplex
Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates.
Herpes Simplex
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Herpes Simplex
Safety Profile of Gutless Adenovirus Vectors Delivered into the Normal Brain Parenchyma: Implications for a Glioma Phase I Clinical Trial.
Herpes Simplex
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Herpes Simplex
Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas.
Herpes Simplex
Satellite DNA induces unstable expression of the adjacent herpes simplex virus tk gene cotransfected in mouse cells.
Herpes Simplex
Scintigraphic imaging of HSVtk gene therapy.
Herpes Simplex
Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene.
Herpes Simplex
Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase.
Herpes Simplex
Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity.
Herpes Simplex
Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging.
Herpes Simplex
Secretion of enzymatically active human renin from mammalian cells using an avian retroviral vector.
Herpes Simplex
Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity.
Herpes Simplex
Segregation of mutant ovalbumins and ovalbumin-globin fusion proteins in Xenopus oocytes. Identification of an ovalbumin signal sequence.
Herpes Simplex
Selectable insertion and deletion mutagenesis of the human cytomegalovirus genome using the Escherichia coli guanosine phosphoribosyl transferase (gpt) gene.
Herpes Simplex
Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination.
Herpes Simplex
Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
Herpes Simplex
Selection of L cell sublines resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Herpes Simplex
Selection of new biologically active molecules from random nucleotide sequences.
Herpes Simplex
Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA library.
Herpes Simplex
Selective ablation of an astroglial subset by toxic gene expression driven by tenascin promoter.
Herpes Simplex
Selective ablation of human embryonic stem cells expressing a "suicide" gene.
Herpes Simplex
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.
Herpes Simplex
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Herpes Simplex
Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
Herpes Simplex
Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.
Herpes Simplex
Selective assay for herpes simplex viruses expressing thymidine kinase.
Herpes Simplex
Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.
Herpes Simplex
Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model.
Herpes Simplex
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.
Herpes Simplex
Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression.
Herpes Simplex
Selective expression of transgene using hypoxia-inducible trans-splicing group I intron ribozyme.
Herpes Simplex
Selective gene therapy for human lung adenocarcinoma by tumor-specific expression of herpes simplex virus thymidine kinase gene.
Herpes Simplex
Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector.
Herpes Simplex
Selective inhibition of human T-lymphotropic virus type I-transformed human T-cell growth by a tax-targeted conditionally cytotoxic recombinant retrovirus.
Herpes Simplex
Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Herpes Simplex
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population.
Herpes Simplex
Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene.
Herpes Simplex
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene.
Herpes Simplex
Selective killing of osteosarcoma cells in culture after retroviral mediated gene transfer of a herpes simplex thymidine kinase suicide gene.
Herpes Simplex
Selective killing of Smad4-negative tumor cells via a designed repressor strategy.
Herpes Simplex
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Herpes Simplex
Selective regression of cells expressing mouse cytoskeleton-associated protein 2 transcript by trans-splicing ribozyme.
Herpes Simplex
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease.
Herpes Simplex
Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.
Herpes Simplex
Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.
Herpes Simplex
Sequence analysis of the human glycoprotein hormone alpha-subunit gene 5'-flanking DNA and identification of a potential regulatory element as an alu repetitive sequence.
Herpes Simplex
Sequence requirement for transcription in vitro of the human corticotropin/beta-lipotropin precursor gene.
Herpes Simplex
Sequence requirement for transcription in vivo of the human preproenkephalin A gene.
Herpes Simplex
Sequence requirements for DNA rearrangements induced by the terminal repeat of herpes simplex virus type 1 KOS DNA.
Herpes Simplex
Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes.
Herpes Simplex
Sequences of herpes simplex virus type 1 that inhibit formation of stable TK+ transformants.
Herpes Simplex
Sequences upstream from the mouse c-mos oncogene may function as a transcription termination signal.
Herpes Simplex
Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
Herpes Simplex
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Herpes Simplex
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes.
Herpes Simplex
Serial MR in gene therapy for recurrent glioblastoma: initial experience and work in progress.
Herpes Simplex
Serial noninvasive in vivo positron emission tomographic tracking of percutaneously intramyocardially injected autologous porcine mesenchymal stem cells modified for transgene reporter gene expression.
Herpes Simplex
Serological specificity of thymidine kinase activity in herpes simplex virus-transformed L cells.
Herpes Simplex
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Herpes Simplex
Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: application to HSV-tk/ganciclovir-mediated cytotoxicity.
Herpes Simplex
Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration.
Herpes Simplex
Sexual dimorphism and growth hormone regulation of a hybrid gene in transgenic mice.
Herpes Simplex
Short-term neuropathological aspects of in vivo suicide gene transfer to the F98 rat glioblastoma using liposomal and viral vectors.
Herpes Simplex
Short-term, high-efficiency expression of transfected DNA.
Herpes Simplex
Shuttle vectors conferring hygromycin B resistance to E. coli and to mammalian cells. Differential expression of carboxyterminal fusion proteins.
Herpes Simplex
Significance of amino acid substitutions in the thymidine kinase gene of herpes simplex virus type 1 for resistance.
Herpes Simplex
Significance of resistance of herpes simplex virus to acyclovir.
Herpes Simplex
Silk-elastin-like hydrogel improves the safety of adenovirus-mediated gene-directed enzyme-prodrug therapy.
Herpes Simplex
Simian virus 40 enhancer increases RNA polymerase density within the linked gene.
Herpes Simplex
Similar efficiency of DNA-liposome complexes and retrovirus-producing cells for HSV-tk suicide gene therapy of peritoneal carcinomatosis.
Herpes Simplex
Simplified cosmid vectors for gene transfer to cultured mammalian cells: isolation of the gene for elongation factor 2 from the mouse.
Herpes Simplex
Simultaneous Cre catalyzed recombination of two alleles to restore neomycin sensitivity and facilitate homozygous mutations.
Herpes Simplex
Simultaneous identification of two populations of sympathetic preganglionic neurons using recombinant herpes simplex virus type 1 expressing different reporter genes.
Herpes Simplex
Simultaneous imaging of temporal changes of NF-?B activity and viable tumor cells in Huh7/NF-?B-tk-luc2/rfp tumor-bearing mice.
Herpes Simplex
Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes.
Herpes Simplex
Site specificity of DNA methylation and expression of herpes simplex thymidine kinase gene.
Herpes Simplex
Site-directed mutagenesis clarifies the substrate position within the three-dimensional model of the active site of herpes simplex virus type-1 thymidine kinase.
Herpes Simplex
Site-directed mutagenesis in the active site of the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: effects on catalytic activity.
Herpes Simplex
Site-directed mutagenesis of herpes simplex virus type 1 thymidine kinase opposes the importance of amino acid positions 251, 321 and 348 for selective recognition of substrate analogs.
Herpes Simplex
Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line.
Herpes Simplex
Sites of integration of herpes simplex virus type-2 thymidine kinase gene in human chromosomes.
Herpes Simplex
Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma.
Herpes Simplex
Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance.
Herpes Simplex
Small Animal PET Imaging of hTERT RNA-Targeted HSV1-tk Gene Expression with Trans-Splicing Ribozyme.
Herpes Simplex
Soluble vascular endothelial growth factor receptor-1 improves therapeutic efficacy of suicide gene therapy in an angiogenesis-independent manner.
Herpes Simplex
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs.
Herpes Simplex
Somatic mutation rates and specificities at TC/AG and GT/CA microsatellite sequences in nontumorigenic human lymphoblastoid cells.
Herpes Simplex
Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
Spatial constraints on polyadenylation signal function.
Herpes Simplex
Spatiotemporal PFQNM visualization of the effect of suicide dendriplexes on dividing HeLa cells.
Herpes Simplex
Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses.
Herpes Simplex
Specific ablation of thyroid follicle cells in adult transgenic mice.
Herpes Simplex
Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Herpes Simplex
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.
Herpes Simplex
Specific regression of human cancer cells by ribozyme-mediated targeted replacement of tumor-specific transcript.
Herpes Simplex
Specific viral antigens in rat cells transformed by herpes simplex virus type 2 and in rat tumors induced by inoculation of transformed cells.
Herpes Simplex
SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1).
Herpes Simplex
Splicing-independent expression of the herpes simplex virus type 1 thymidine kinase gene is mediated by three cis-acting RNA subelements.
Herpes Simplex
Spontaneous and engineered mutant mice as models for experimental and comparative pathology: history, comparison, and developmental technology.
Herpes Simplex
Spontaneous and restriction enzyme-induced chromosomal recombination in mammalian cells.
Herpes Simplex
Spying on cancer: molecular imaging in vivo with genetically encoded reporters.
Herpes Simplex
Stability of retrovirally transduced markers in a rat cell line.
Herpes Simplex
Stability of the transformants obtained by phage particle-mediated gene transfer.
Herpes Simplex
Stable expression in mouse cells of nuclear neoantigen after transfer of a 3.4-megadalton cloned fragment of Epstein-Barr virus DNA.
Herpes Simplex
Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting.
Herpes Simplex
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy.
Herpes Simplex
STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.
Herpes Simplex
Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas.
Herpes Simplex
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis.
Herpes Simplex
Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays.
Herpes Simplex
Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.
Herpes Simplex
Stereoisomeric selectivity of human deoxyribonucleoside kinases.
Herpes Simplex
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.
Herpes Simplex
Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors.
Herpes Simplex
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.
Herpes Simplex
Stimulation of alpha 1 (I) procollagen gene expression in NIH-3T3 cells by the human T cell leukemia virus type 1 (HTLV-1) Tax gene.
Herpes Simplex
Stimulation of human cellular thymidine kinase activity during abortive infection with herpes simplex virus type 2.
Herpes Simplex
Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro.
Herpes Simplex
Stimulation of thymidine kinase activity in baculovirus infected cells is not due to a virus-coded enzyme.
Herpes Simplex
StpC-based gene therapy targeting latent reservoirs of HIV-1.
Herpes Simplex
Strategy for achieving selective killing of carcinomas.
Herpes Simplex
Strength and specificity of different gene promoters in oral cancer cells.
Herpes Simplex
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Herpes Simplex
Structural characteristics of cationic liposomes with potent enhancing effect on retroviral transduction into human hepatoma cells.
Herpes Simplex
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes.
Herpes Simplex
Structure and expression of human globin genes introduced into mouse fibroblasts.
Herpes Simplex
Structure and inducible regulation of the human c-erb B2/neu promoter.
Herpes Simplex
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
Herpes Simplex
Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids.
Herpes Simplex
Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.
Herpes Simplex
Structures of replacement vectors for efficient gene targeting.
Herpes Simplex
Studies of HIV-2 promoter activity and cell specific ablation.
Herpes Simplex
Studies on cellular tandemization of herpes simplex virus thymidine kinase DNA.
Herpes Simplex
Studies on interactions of dTK-HSV mutants with neurons in vitro.
Herpes Simplex
Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma.
Herpes Simplex
Study of [(18)F]FLT and [(123)I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes.
Herpes Simplex
Studying DNA mutations in human cells with the use of an integrated HSV thymidine kinase target gene.
Herpes Simplex
Studying the biodistribution of positron emission tomography reporter probes in mice.
Herpes Simplex
Substitution of a TATA box from a herpes simplex virus late gene in the viral thymidine kinase promoter alters ICP4 inducibility but not temporal expression.
Herpes Simplex
Substrate diversity of herpes simplex virus thymidine kinase. Impact Of the kinematics of the enzyme.
Herpes Simplex
Substrate specificity of feline and canine herpesvirus thymidine kinase.
Herpes Simplex
Substrate specificity of three viral thymidine kinases (TK): vaccinia virus TK, feline herpesvirus TK, and canine herpesvirus TK.
Herpes Simplex
Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Herpes Simplex
Suicide gene and cytokines combined nonviral gene therapy for spontaneous canine melanoma.
Herpes Simplex
Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter.
Herpes Simplex
Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles.
Herpes Simplex
Suicide gene therapy for hepatocellular carcinoma cells by survivin promoter-driven expression of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Suicide gene therapy for human oral squamous cell carcinoma cell lines with adeno-associated virus vector.
Herpes Simplex
Suicide gene therapy for human uterine adenocarcinoma cells using herpes simplex virus thymidine kinase.
Herpes Simplex
Suicide Gene Therapy for Oral Squamous Cell Carcinoma.
Herpes Simplex
Suicide gene therapy for plasma cell tumors.
Herpes Simplex
Suicide gene therapy for treatment of retinoblastoma in a murine model.
Herpes Simplex
Suicide gene therapy for urogenital cancer: current outcome and prospects.
Herpes Simplex
Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application.
Herpes Simplex
Suicide Gene Therapy Mediated with Exosomes Produced by Mesenchymal Stem/Stromal Cells Stably Transduced with HSV Thymidine Kinase.
Herpes Simplex
Suicide gene therapy of chemically induced mammary tumor in rat: efficacy and distant bystander effect.
Herpes Simplex
Suicide gene therapy of hepatocellular carcinoma and delivery procedure and route of therapeutic gene in vivo.
Herpes Simplex
Suicide gene therapy of ovarian cancer: an experimental study in rats using retroviral-mediated transfer of herpes simplex virus thymidine kinase gene.
Herpes Simplex
Suicide gene therapy of rhabdomyosarcoma.
Herpes Simplex
Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer.
Herpes Simplex
Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude mice.
Herpes Simplex
Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line in vitro.
Herpes Simplex
Suicide gene therapy using E. coli beta-galactosidase.
Herpes Simplex
Suicide gene therapy using reducible poly (oligo-D-arginine) for the treatment of spinal cord tumors.
Herpes Simplex
Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy.
Herpes Simplex
Suicide gene therapy with Herpes simplex virus thymidine kinase and ganciclovir is enhanced with connexins to improve gap junctions and bystander effects.
Herpes Simplex
Suicide gene therapy: possible applications in haematopoietic disorders.
Herpes Simplex
Suicide Gene-Mediated Sequencing Ablation Revealed the Potential Therapeutic Mechanism of Induced Pluripotent Stem Cell-Derived Cardiovascular Cell Patch Post-Myocardial Infarction.
Herpes Simplex
Suicide genes as safety switches in T lymphocytes.
Herpes Simplex
Suicide genes: monitoring cells in patients with a safety switch.
Herpes Simplex
Suicide HSVtk gene delivery by neurotensin-polyplex nanoparticles via the bloodstream and GCV Treatment specifically inhibit the growth of human MDA-MB-231 triple negative breast cancer tumors xenografted in athymic mice.
Herpes Simplex
Suicide-gene-Transduced donor T-cells for controlled graft-versus-host disease and graft-versus-tumor.
Herpes Simplex
Suicide-gene-transduced T-cells for the regulation of the graft-versus-leukemia effect.
Herpes Simplex
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Herpes Simplex
Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.
Herpes Simplex
Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53.
Herpes Simplex
Suppression of intrachromosomal gene conversion in mammalian cells by small degrees of sequence divergence.
Herpes Simplex
Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation.
Herpes Simplex
Suppression of neointima formation by targeting ?-catenin/TCF pathway.
Herpes Simplex
Suppression of ocular herpes recurrences by a thymidine kinase inhibitor in squirrel monkeys.
Herpes Simplex
Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy.
Herpes Simplex
Surfactant protein A-directed toxin gene kills lung cancer cells in vitro.
Herpes Simplex
Susceptibility of mesothelioma cell lines to adeno-associated virus 2 vector-based suicide gene therapy.
Herpes Simplex
Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.
Herpes Simplex
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Herpes Simplex
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Herpes Simplex
Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea.
Herpes Simplex
Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan.
Herpes Simplex
Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells.
Herpes Simplex
Syntheses of virus-induced thymidine kinase and viral DNA in herpes simplex type 1 virus-infected chick embryo fibroblasts.
Herpes Simplex
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
Herpes Simplex
Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
Herpes Simplex
Synthesis and antiviral activity of carbocyclic oxetanocin analogues (C-OXT-A, C-OXT-G) and related compounds. II.
Herpes Simplex
Synthesis and antiviral evaluation of ?-l-2'-deoxythreofuranosyl nucleosides.
Herpes Simplex
Synthesis and antiviral evaluation of carbocyclic analogues of 2-amino-6-substituted-purine 3'-deoxyribofuranosides.
Herpes Simplex
Synthesis and application of poly(ethylene glycol)-co-poly(?-amino ester) copolymers for small cell lung cancer gene therapy.
Herpes Simplex
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
Herpes Simplex
Synthesis and biological activity of dansyl thymidines.
Herpes Simplex
Synthesis and biological evaluation of a new acyclic pyrimidine derivative as a probe for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Herpes Simplex
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
Herpes Simplex
Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging.
Herpes Simplex
Synthesis and characterization of a C6 nucleoside analogue for the in vivo imaging of the gene expression of herpes simplex virus type-1 thymidine kinase (HSV1 TK).
Herpes Simplex
Synthesis and evaluation of 2'-deoxy-2'-18F-fluoro-5-fluoro-1-beta-D-arabinofuranosyluracil as a potential PET imaging agent for suicide gene expression.
Herpes Simplex
Synthesis and evaluation of a C-6 alkylated pyrimidine derivative for the in vivo imaging of HSV1-TK gene expression.
Herpes Simplex
Synthesis and evaluation of cis-1-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-5-[(124)I]iodouracil: a new potential PET imaging agent for HSV1-tk expression.
Herpes Simplex
Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression.
Herpes Simplex
Synthesis and in vitro evaluation of 5-[(18)f]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression.
Herpes Simplex
Synthesis and preclinical evaluation of a new C-6 alkylated pyrimidine derivative as a PET imaging agent for HSV1-tk gene expression.
Herpes Simplex
Synthesis of (99m)Tc(CO)(3)-deoxyuridine derivatives as potential HSV1-tk gene expression imaging agents.
Herpes Simplex
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.
Herpes Simplex
Synthesis of 2-amino-6-(4-[11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers.
Herpes Simplex
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Herpes Simplex
Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene: an unexpected chelating effect.
Herpes Simplex
Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes.
Herpes Simplex
Synthesis of a probe for monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI.
Herpes Simplex
Synthesis of conformationally North-locked pyrimidine nucleosides built on an oxabicyclo[3.1.0]hexane scaffold.
Herpes Simplex
Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human beta-globin genes.
Herpes Simplex
Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents.
Herpes Simplex
Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues.
Herpes Simplex
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
Herpes Simplex
Synthetic radiation-inducible promoters mediated HSV-TK/GCV gene therapy in the treatment of oral squamous cell carcinoma.
Herpes Simplex
Systematic evaluation of chimeric marker genes on dicistronic transcription units for regulated expression of transgenes in vitro and in vivo.
Herpes Simplex
Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient.
Herpes Simplex
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis.
Herpes Simplex
Systemic delivery of fusogenic membrane glycoprotein-expressing neural stem cells to selectively kill tumor cells.
Herpes Simplex
Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.
Herpes Simplex
T cell suicide gene therapy to aid haematopoietic stem cell transplantation.
Herpes Simplex
T cell transduction and suicide with an enhanced mutant thymidine kinase.
Herpes Simplex
T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: comparison of four different infection protocols.
Herpes Simplex
T-Cell suicide gene therapy for organ transplantation: induction of long-lasting tolerance to allogeneic heart without generalized immunosuppression.
Herpes Simplex
TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.
Herpes Simplex
Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies.
Herpes Simplex
Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.
Herpes Simplex
Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine.
Herpes Simplex
Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay.
Herpes Simplex
Targeted delivery of DNA encoding cytotoxic proteins through high-affinity fibroblast growth factor receptors.
Herpes Simplex
Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene.
Herpes Simplex
Targeted expression of E. coli purine nucleoside phosphorylase and Fludara for prostate cancer therapy.
Herpes Simplex
Targeted expression of herpes simplex virus thymidine kinase in adenovirus-infected cells reduces virus titers upon treatment with ganciclovir in vitro.
Herpes Simplex
Targeted gene delivery by tropism-modified adenoviral vectors.
Herpes Simplex
Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor.
Herpes Simplex
Targeted gene therapy for cancer: herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells.
Herpes Simplex
Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system.
Herpes Simplex
Targeted gene therapy.
Herpes Simplex
Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using anti-epidermal growth factor receptor antibody: immunogene approach.
Herpes Simplex
Targeted killing effects of double CD and TK suicide genes controlled by survivin promoter on gastric cancer cell.
Herpes Simplex
Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter.
Herpes Simplex
Targeted killing of migrating glioma cells by injection of HTK-modified glioma cells.
Herpes Simplex
Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer.
Herpes Simplex
Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA.
Herpes Simplex
Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors.
Herpes Simplex
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
Herpes Simplex
Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair.
Herpes Simplex
Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells.
Herpes Simplex
Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.
Herpes Simplex
Targeting of an inducible toxic phenotype in animal cells.
Herpes Simplex
Targeting of herpes simplex virus 1 thymidine kinase gene sequences into the OCT4 locus of human induced pluripotent stem cells.
Herpes Simplex
Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors.
Herpes Simplex
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Herpes Simplex
Targeting Tumor Stroma Using Engineered Mesenchymal Stem Cells Reduces the Growth of Pancreatic Carcinoma.
Herpes Simplex
Tat8-TK/GCV Suicide Gene Therapy Induces Pancreatic Tumor Regression In Vivo.
Herpes Simplex
Tat8-TK/GCV suicide gene therapy induces pancreatic tumor regression in vivo.
Herpes Simplex
TATA-dependent enhancer stimulation of promoter activity in mice is developmentally acquired.
Herpes Simplex
Tentative novel mechanism of the bystander effect in glioma gene therapy with HSV-TK/GCV system.
Herpes Simplex
TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection.
Herpes Simplex
The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.
Herpes Simplex
The 5'-flanking region of the mouse thymidylate synthase gene is necessary but not sufficient for normal regulation in growth-stimulated cells.
Herpes Simplex
The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription.
Herpes Simplex
The 5'-flanking sequences of the human growth hormone gene contain a cell-specific control element.
Herpes Simplex
The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase.
Herpes Simplex
The adeno-associated virus-mediated HSV-TK/GCV suicide system: a potential strategy for the treatment of bladder carcinoma.
Herpes Simplex
The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells.
Herpes Simplex
The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring.
Herpes Simplex
The alpha promoter regulator-ovalbumin chimeric gene resident in human cells is regulated like the authentic alpha 4 gene after infection with herpes simplex virus 1 mutants in alpha 4 gene.
Herpes Simplex
The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells.
Herpes Simplex
The anti-tumor effect of human monocyte-derived dendritic cells loaded with HSV-TK/GCV induced dying cells.
Herpes Simplex
The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication.
Herpes Simplex
The association of herpes simplex virus with squamous carcinoma of the cervix, and studies of the virus thymidine kinase gene.
Herpes Simplex
The association of thymidine kinase activity and thymidine transport in Escherichia coli.
Herpes Simplex
The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions.
Herpes Simplex
The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.
Herpes Simplex
The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.
Herpes Simplex
The clinical course and management of cervical cancer with splenic metastasis: Case report and review of the literature.
Herpes Simplex
The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice.
Herpes Simplex
The construction of cosmid libraries which can be used to transform eukaryotic cells.
Herpes Simplex
The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.
Herpes Simplex
The design, synthesis and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase.
Herpes Simplex
The drug verapamil inhibits bystander killing but not cell suicide in thymidine kinase-ganciclovir prodrug-activated gene therapy.
Herpes Simplex
The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a.
Herpes Simplex
The effect of cell synchronization on the efficiency of stable gene transfer by electroporation.
Herpes Simplex
The effect of E1 mutations on biochemical transformation by an adenovirus carrying the herpes simplex virus thymidine kinase gene in region E3.
Herpes Simplex
The effect of matrix attached regions (MAR) and specialized chromatin structure (SCS) on the expression of gene constructs in cultured cells and in transgenic mice.
Herpes Simplex
The effect of promoter strength in adenoviral vectors containing herpes simplex virus thymidine kinase on cancer gene therapy in vitro and in vivo.
Herpes Simplex
The effect of substrate binding on the conformation and structural stability of Herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
Herpes Simplex
The effects of calcium channel blockers on nuclear factor kappa B activation in the mesangium cells.
Herpes Simplex
The effects of insertions on mammalian intrachromosomal recombination.
Herpes Simplex
The efficacy of retroviral herpes simplex virus thymidine kinase gene transfer and ganciclovir treatment on the inhibition of melanoma growth in vitro and in vivo.
Herpes Simplex
The efficiency of genetic transformation of mammalian cells by transfection and microinjection depends on the transferred gene.
Herpes Simplex
The Epstein-Barr virus (EBV) early promoter DR contains a cis-acting element responsive to the EBV transactivator EB1 and an enhancer with constitutive and inducible activities.
Herpes Simplex
The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase.
Herpes Simplex
The equine herpesvirus type 1 immediate-early gene product contains an acidic transcriptional activation domain.
Herpes Simplex
The evaluation of adenoviral p53-mediated bystander effect in gene therapy of cancer.
Herpes Simplex
The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.
Herpes Simplex
The follicle-stimulating hormone (FSH) beta- and common alpha-subunits are expressed in mouse testis, as determined in wild-type mice and those transgenic for the FSH beta-subunit/herpes simplex virus thymidine kinase fusion gene.
Herpes Simplex
The FSH beta-subunit promoter directs the expression of Herpes simplex virus type 1 thymidine kinase to the testis of transgenic mice.
Herpes Simplex
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
Herpes Simplex
The gene encoding the myeloid-related protein 14 (MRP14), a calcium-binding protein expressed in granulocytes and monocytes, contains a potent enhancer element in the first intron.
Herpes Simplex
The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPbeta.
Herpes Simplex
The herpes simplex virus thymidine kinase gene as a conditional negative-selection marker gene in Arabidopsis thaliana.
Herpes Simplex
The herpes simplex virus thymidine kinase gene is not transcribed in Saccharomyces cerevisiae.
Herpes Simplex
The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element.
Herpes Simplex
The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter.
Herpes Simplex
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.
Herpes Simplex
The human cytomegalovirus regulatory protein UL69 and its effect on mRNA export.
Herpes Simplex
The human histidine decarboxylase promoter is regulated by gastrin and phorbol 12-myristate 13-acetate through a downstream cis-acting element.
Herpes Simplex
The human norepinephrine transporter in combination with 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy.
Herpes Simplex
The immunoglobulin octanucleotide: independent activity and selective interaction with enhancers.
Herpes Simplex
The impact of retroviral suicide gene transduction procedures on T cells.
Herpes Simplex
The in vitro evaluation of nucleoside analogues as probes for use in the noninvasive diagnosis of herpes simplex encephalitis.
Herpes Simplex
The influence of chromosomal location on the expression of two transgenes in mice.
Herpes Simplex
The insulinoma-associated 1: a novel promoter for targeted cancer gene therapy for small-cell lung cancer.
Herpes Simplex
The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes.
Herpes Simplex
The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene.
Herpes Simplex
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.
Herpes Simplex
The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming.
Herpes Simplex
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells.
Herpes Simplex
The murine alpha B-crystallin/small heat shock protein enhancer: identification of alpha BE-1, alpha BE-2, alpha BE-3, and MRF control elements.
Herpes Simplex
The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication.
Herpes Simplex
The N-terminal region of E2F-1 is required for transcriptional activation of a new class of target promoter.
Herpes Simplex
The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction.
Herpes Simplex
The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants.
Herpes Simplex
The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
Herpes Simplex
The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
Herpes Simplex
The piggyback transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
Herpes Simplex
The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene.
Herpes Simplex
The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.
Herpes Simplex
The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease.
Herpes Simplex
The rational of catalytic activity of herpes simplex virus thymidine kinase. a combined biochemical and quantum chemical study.
Herpes Simplex
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
Herpes Simplex
The region of mouse mammary tumor virus DNA containing the long terminal repeat includes a long coding sequence and signals for hormonally regulated transcription.
Herpes Simplex
The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line.
Herpes Simplex
The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells.
Herpes Simplex
The replication of viral and cellular DNA in human herpesvirus 6-infected cells.
Herpes Simplex
The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
Herpes Simplex
The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
Herpes Simplex
The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells.
Herpes Simplex
The role of herpes simplex thymidine kinase expression in neurovirulence and latency in newborn vs. adult mice.
Herpes Simplex
The role of herpes simplex virus thymidine kinase in the treatment of solid tumours.
Herpes Simplex
The role of herpes simplex virus type 1 thymidine kinase in pathogenesis.
Herpes Simplex
The role of herpes simplex virus-1 thymidine kinase alanine 168 in substrate specificity.
Herpes Simplex
The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene.
Herpes Simplex
The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: assessment of antitumor efficacy and toxicity.
Herpes Simplex
The search for homology does not limit the rate of extrachromosomal homologous recombination in mammalian cells.
Herpes Simplex
The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene.
Herpes Simplex
The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator.
Herpes Simplex
The site of integration of the herpes simplex virus type 1 thymidine kinase gene in human cells transformed by an HSV-1 DNA fragment.
Herpes Simplex
The size and ratio of homologous sequence to non-homologous sequence in gene disruption cassette influences the gene targeting efficiency in Beauveria bassiana.
Herpes Simplex
The Sp1 transcription factor regulates cell type-specific transcription of MUC1.
Herpes Simplex
The stereochemical course of phosphoryl transfer catalyzed by herpes simplex virus type I-induced thymidine kinase.
Herpes Simplex
The structure and function of a eukaryotic promoter.
Herpes Simplex
The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
Herpes Simplex
The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway.
Herpes Simplex
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters.
Herpes Simplex
The three-dimensional structure of thymidine kinase from herpes simplex virus type 1.
Herpes Simplex
The thymidine kinase gene of herpes simplex virus type 1: cell-free protein synthesis and substrate specificity studies.
Herpes Simplex
The thymidine kinase/ganciclovir-mediated "suicide" effect is variable in different tumor cells.
Herpes Simplex
The transcription of human alpha 1(I) procollagen gene (COL1A1) is suppressed by tumour necrosis factor-alpha through proximal short promoter elements: evidence for suppression mechanisms mediated by two nuclear-factorbinding sites.
Herpes Simplex
The treatment of malignant mesothelioma with a gene modified cancer cell line: a phase I study.
Herpes Simplex
The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones.
Herpes Simplex
The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei.
Herpes Simplex
The zinc ring finger in the bICP0 protein encoded by bovine herpesvirus-1 mediates toxicity and activates productive infection.
Herpes Simplex
Theranostic Imaging of Cancer Gene Therapy.
Herpes Simplex
Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease.
Herpes Simplex
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.
Herpes Simplex
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
Herpes Simplex
Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase.
Herpes Simplex
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
Herpes Simplex
Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene.
Herpes Simplex
Thy-1 tk transgenic mice with a conditional lymphocyte deficiency.
Herpes Simplex
Thymidine kinase (TK) activity in herpes simplex virus type 1 recombinants that carry insertions affecting regulation of the TK gene.
Herpes Simplex
Thymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment.
Herpes Simplex
Thymidine kinase activity of biochemically transformed mouse cells after superinfection by thymidine kinase-negative, temperature-sensitive, herpes simplex virus mutants.
Herpes Simplex
Thymidine kinase activity of herpes simplex virus temperature-sensitive mutants.
Herpes Simplex
Thymidine kinase activity of ocular herpes simplex isolates resistant to IUDR therapy.
Herpes Simplex
Thymidine kinase as a selectable marker for studying the biogenesis of glycosomes in Trypanosoma brucei.
Herpes Simplex
Thymidine kinase deficient human cells have increased UV sensitivity in their capacity to support herpes simplex virus but normal UV sensitivity for colony formation.
Herpes Simplex
Thymidine kinase deletion mutants of herpes simplex virus type 1.
Herpes Simplex
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
Herpes Simplex
Thymidine kinase gene delivery using curcumin loaded peptide micelles as a combination therapy for glioblastoma.
Herpes Simplex
Thymidine Kinase Gene Modified Bone Marrow Mesenchymal Stem Cells as Vehicles for Anti-tumor Therapy.
Herpes Simplex
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
Herpes Simplex
Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer.
Herpes Simplex
Thymidine kinase gene transfer by herpes simplex virus.
Herpes Simplex
Thymidine kinase mutants obtained by random sequence selection.
Herpes Simplex
Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.
Herpes Simplex
Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency.
Herpes Simplex
Thymidine kinase of herpes simplex virus type 1 strain KOS lacks mutator activity.
Herpes Simplex
Thymidine kinase sequence analysis of herpes simplex virus type 1 strains present in different compartments in an atypical impetiginous rash on the lesional skin of a burn patient.
Herpes Simplex
Thymidine Kinase Suicide Gene-mediated Ganciclovir Ablation of Autologous Gene-modified Rhesus Hematopoiesis.
Herpes Simplex
Thymidine kinase, DNA synthesis and cancer.
Herpes Simplex
Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production.
Herpes Simplex
Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.
Herpes Simplex
Thymidine kinaseless revertants of Ltk- cells transformed by herpes simplex virus type 1 are resistant to retransformation by homologous virus.
Herpes Simplex
Thymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates.
Herpes Simplex
Thymidine utilization by tut mutants and facile cloning of mutant alleles by plasmid conversion in S. cerevisiae.
Herpes Simplex
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Herpes Simplex
Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon.
Herpes Simplex
Thyroid hormone-responsive elements of the prolactin gene: evidence for both positive and negative regulation.
Herpes Simplex
Thyroid hormones regulate rat thyrotropin beta gene promoter activity expressed in GH3 cells.
Herpes Simplex
Tissue specific promoters in targeting systemically delivered gene therapy.
Herpes Simplex
Tissue-specific determinants of human atrial natriuretic factor gene expression in cardiac tissue.
Herpes Simplex
Tissue-specific DNA binding of nuclear proteins that bind to the adenovirus inverted terminal repeat.
Herpes Simplex
Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice.
Herpes Simplex
Tissue-specific expression of HSV-tk gene can induce efficient antitumor effect and protective immunity to wild-type hepatocellular carcinoma.
Herpes Simplex
Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors.
Herpes Simplex
Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems.
Herpes Simplex
Titration of Variant HSV1-tk Gene Expression to Determine the Sensitivity of 18F-FHBG PET Imaging in a Prostate Tumor.
Herpes Simplex
TK-GFP fusion gene virus vectors as tools for studying the features of HSV-TK/ganciclovir cancer gene therapy in vivo.
Herpes Simplex
Tomato thymidine kinase-based suicide gene therapy for malignant glioma-an alternative for Herpes Simplex virus-1 thymidine kinase.
Herpes Simplex
Total vascular exclusion of the liver enhances the efficacy of retroviral-mediated associated thymidine kinase and interleukin-2 genes transfer against multiple hepatic tumors in rats.
Herpes Simplex
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells.
Herpes Simplex
Towards ?-globin gene-targeting with integrase-defective lentiviral vectors
Herpes Simplex
Towards ?-globin gene-targeting with integrase-defective lentiviral vectors.
Herpes Simplex
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.
Herpes Simplex
Towards Fibroid Gene Therapy: Adenovirus-Mediated Delivery of Herpes Simplex Virus 1 Thymidine Kinase Gene/Ganciclovir Shrinks Uterine Leiomyoma in the Eker Rat Model.
Herpes Simplex
Towards global and long-term neurological gene therapy: unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS.
Herpes Simplex
Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer.
Herpes Simplex
Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells.
Herpes Simplex
Toxicity studies in thymidine kinase-deficient herpes simplex virus therapy for malignant astrocytoma.
Herpes Simplex
Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors.
Herpes Simplex
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.
Herpes Simplex
trans activation of gene expression by v-myb.
Herpes Simplex
trans activation of the simian virus 40 late promoter by large T antigen requires binding sites for the cellular transcription factor TEF-1.
Herpes Simplex
Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene.
Herpes Simplex
trans-activation of cellular and viral promoters by a transforming nonkaryophilic simian virus 40 large T antigen.
Herpes Simplex
Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62.
Herpes Simplex
Trans-complementing adenoviral vectors for oncolytic therapy of malignant melanoma.
Herpes Simplex
Transactivation of a late herpes simplex virus promoter.
Herpes Simplex
Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide from HIV-1 Tat.
Herpes Simplex
Transcription and translation of the herpes simplex virus type 1 thymidine kinase gene after microinjection into Xenopus laevis oocytes.
Herpes Simplex
Transcription factor AP-2 controls transcription of the human transforming growth factor-alpha gene.
Herpes Simplex
Transcription factor Sp1 recognizes promoter sequences from the monkey genome that are simian virus 40 promoter.
Herpes Simplex
Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter.
Herpes Simplex
Transcription from the polyoma late promoter in cells stably transformed by chimeric plasmids.
Herpes Simplex
Transcription initiation of transfected mouse mammary tumor virus LTR DNA is regulated by glucocorticoid hormones.
Herpes Simplex
Transcription of a trout protamine gene in vitro: the effects of alteration of promoters.
Herpes Simplex
Transcription of DNA injected into Xenopus oocytes is influenced by template topology.
Herpes Simplex
Transcription of herpes simplex virus genes in vivo: overlap of a late promoter with the 3' end of the early thymidine kinase gene.
Herpes Simplex
Transcription of the simian virus 40 genome in DNA-transformed murine teratocarcinoma stem cells.
Herpes Simplex
Transcriptional activation of fibroblast growth factor 1.B promoter is mediated through an 18-base pair cis-acting element.
Herpes Simplex
Transcriptional activation of NF-kappa B activity by Epstein-Barr virus (EBV) LMP1 as a selective therapeutic strategy for EBV-associated diseases.
Herpes Simplex
Transcriptional analysis of the 5'-noncoding region of the human involucrin gene.
Herpes Simplex
Transcriptional induction of the human prolactin gene by cAMP requires two cis-acting elements and at least the pituitary-specific factor Pit-1.
Herpes Simplex
Transcriptional insulation of the human keratin 18 gene in transgenic mice.
Herpes Simplex
Transcriptional regulation of Kaposi's sarcoma-associated herpesvirus-encoded oncogene viral interferon regulatory factor by a novel transcriptional silencer, Tis.
Herpes Simplex
Transcriptional regulation of MHC class I gene expression in rat oligodendrocytes.
Herpes Simplex
Transcriptional repression mediated by the PR domain zinc finger gene RIZ.
Herpes Simplex
Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins.
Herpes Simplex
Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma.
Herpes Simplex
Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter.
Herpes Simplex
Transcriptionally targeted in vivo gene therapy for carcinoembrionic antigen-producing adenocarcinoma.
Herpes Simplex
Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer.
Herpes Simplex
Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease.
Herpes Simplex
Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector.
Herpes Simplex
Transduction of a fiber-mutant adenovirus for the HSVtk gene highly augments the cytopathic effect towards gliomas.
Herpes Simplex
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
Herpes Simplex
Transduction of the Chinese hamster ovary aprt gene by herpes simplex virus.
Herpes Simplex
Transduction of thymidine phosphorylase cDNA facilitates efficacy of cytosine deaminase/5-FC gene therapy for malignant brain tumor.
Herpes Simplex
Transfection and homologous recombination involving single-stranded DNA substrates in mammalian cells and nuclear extracts.
Herpes Simplex
Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays.
Herpes Simplex
Transfection of genes for human cell surface antigens identified by monoclonal antibodies.
Herpes Simplex
Transfection of mouse cells with thymidine kinase gene of herpes simplex virus.
Herpes Simplex
Transfection of mouse fibroblast cells with a promoterless herpes simplex virus thymidine kinase gene: number of integrated gene copies and structure of single and amplified gene sequences.
Herpes Simplex
Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes.
Herpes Simplex
Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy.
Herpes Simplex
Transfection with the isolated herpes simplex virus thymidine kinase genes. I. Minimal size of the active fragments from HSV-1 and HSV-2.
Herpes Simplex
Transfection with the isolated herpes simplex virus thymidine kinase genes. II. Evidence for amplification of viral and adjacent cellular DNA sequences.
Herpes Simplex
Transfer and expression of herpes simplex virus thymidine kinase and human globin genes in mammalian cells studied by spot hybridization assays.
Herpes Simplex
Transfer and expression of the gene encoding a human myeloid membrane antigen (gp150).
Herpes Simplex
Transfer of a mutant viral thymidine kinase gene results in temperature-sensitive mouse cells.
Herpes Simplex
Transfer of genes to Chinese hamster ovary cells by DNA-mediated transformation.
Herpes Simplex
Transfer of herpes simplex virus thymidine kinase synthesized in bacteria by a high-expression plasmid to tissue culture cells by protoplast fusion.
Herpes Simplex
Transfer of human globin genes to erythroleukemic mouse cells.
Herpes Simplex
Transfer of nonselectable genes into mouse teratocarcinoma cells and transcription of the transferred human beta-globin gene.
Herpes Simplex
Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA.
Herpes Simplex
Transfer of the herpes simplex thymidine kinase gene from human cells to mouse cells by means of metaphase chromosomes.
Herpes Simplex
Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus.
Herpes Simplex
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.
Herpes Simplex
Transformation depending on intermolecular homologous recombination is stimulated by UV damage in transfected DNA.
Herpes Simplex
Transformation of human 143 tk- cells with plasmids containing the gene encoding the adenovirus DNA-binding protein.
Herpes Simplex
Transformation of L cells with virus thymidine kinase genes introduced by red cell-mediated microinjection.
Herpes Simplex
Transforming potential of deletion mutants of the SV40 T antigen coding gene in Syrian hamster cells.
Herpes Simplex
Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression.
Herpes Simplex
Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice.
Herpes Simplex
Transgenic indicator mice for studying activated retinoic acid receptors during development.
Herpes Simplex
Transgenic mouse models for gonadal tumorigenesis.
Herpes Simplex
Transgenic reporter mouse for bioluminescence imaging of herpes simplex virus 1 infection in living mice.
Herpes Simplex
Transient expression analyses of DNA extending 2.4 kb upstream of the human renin gene.
Herpes Simplex
Transient expression of deletion mutants of the herpes simplex virus thymidine kinase-encoding gene in mouse fibroblast cells.
Herpes Simplex
Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency.
Herpes Simplex
Traumatic brain injury-induced hippocampal neurogenesis requires activation of early nestin-expressing progenitors.
Herpes Simplex
Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene.
Herpes Simplex
Treatment of experimental osteosarcoma tumors in rat by herpes simplex thymidine kinase gene transfer and ganciclovir.
Herpes Simplex
Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Treatment of human papillomavirus (HPV) type 16-infected cells using herpes simplex virus type 1 thymidine kinase-mediated gene therapy transcriptionally regulated by the HPV E2 protein.
Herpes Simplex
Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes.
Herpes Simplex
Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase.
Herpes Simplex
Treatment of medullary thyroid carcinoma by combined expression of suicide and interleukin-2 genes.
Herpes Simplex
Treatment of mesothelioma with gene-modified PA1STK cells and ganciclovir: a phase I study.
Herpes Simplex
Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial.
Herpes Simplex
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.
Herpes Simplex
Treatment of rat experimental brain tumors by herpes simplex virus thymidine kinase gene-transduced allogeneic tumor cells and ganciclovir.
Herpes Simplex
Treatment of rat gliomas with recombinant retrovirus harboring Herpes simplex virus thymidine kinase suicide gene.
Herpes Simplex
Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir.
Herpes Simplex
Treatment of thyroid carcinoma cells with four different suicide gene/prodrug combinations in vitro.
Herpes Simplex
Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus.
Herpes Simplex
Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses.
Herpes Simplex
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Herpes Simplex
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Herpes Simplex
Tumor Restrictive Suicide Gene Therapy for Glioma Controlled by the FOS Promoter.
Herpes Simplex
Tumor Tropism of Intravenously Injected Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model.
Herpes Simplex
Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy.
Herpes Simplex
Tumor-directed gene therapy in mice using a composite nonviral gene delivery system consisting of the piggyBac transposon and polyethylenimine.
Herpes Simplex
Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.
Herpes Simplex
Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene.
Herpes Simplex
Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter.
Herpes Simplex
Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET.
Herpes Simplex
Tumor-specific promoter-driven adenoviral therapy for insulinoma.
Herpes Simplex
Tumor-targeted Salmonella as a novel anticancer vector.
Herpes Simplex
Tumor-Targeted Salmonella: Strain Development and Expression of the HSV-tK Effector Gene.
Herpes Simplex
Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells.
Herpes Simplex
Tumoricidal effect of human olfactory ensheathing cell mediated suicide gene therapy in human glioblastoma cells.
Herpes Simplex
Turning immunological memory into amnesia by depletion of dividing T cells.
Herpes Simplex
Two functional estrogen response elements are located upstream of the major chicken vitellogenin gene.
Herpes Simplex
Two thymidine kinase deficient herpes simplex viruses exhibit unexpected virulence properties.
Herpes Simplex
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter.
Herpes Simplex
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Herpes Simplex
Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters.
Herpes Simplex
Two-step transcriptional amplification-lipid-based nanoparticles using PSMA or midkine promoter for suicide gene therapy in prostate cancer.
Herpes Simplex
Type and position of promoter elements in retroviral vectors have substantial effects on the expression level of an enhanced green fluorescent protein reporter gene.
Herpes Simplex
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases.
Herpes Simplex
Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice.
Herpes Simplex
Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammlian cells.
Herpes Simplex
Ultraviolet stimulation of intermolecular homologous recombination in Chinese hamster ovary cells.
Herpes Simplex
Ultraviolet-induced reactivation, amplification, and hypomethylation of a herpes simplex virus thymidine kinase gene.
Herpes Simplex
Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response.
Herpes Simplex
Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase.
Herpes Simplex
Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.
Herpes Simplex
Unequal homologous recombination between tandemly arranged sequences stably incorporated into cultured rat cells.
Herpes Simplex
Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir.
Herpes Simplex
Uptake of [125I]iododeoxycytidine by cells infected with herpes simplex virus: a rapid screening test for resistance to acyclovir.
Herpes Simplex
Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer.
Herpes Simplex
Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cells.
Herpes Simplex
Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1.
Herpes Simplex
Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice.
Herpes Simplex
Use of DNA-mediated gene transfer to analyze the role of H-2Ld in controlling the specificity of anti-vesicular stomatitis virus cytotoxic T cells.
Herpes Simplex
Use of EBV-based Vector/HVJ-liposome complex vector for targeted gene therapy of EBV-associated neoplasms.
Herpes Simplex
Use of Epstein-Barr virus nuclear antigen-1 in targeted therapy of EBV-associated neoplasia.
Herpes Simplex
Use of gastrin-releasing peptide promoter for specific expression of thymidine kinase gene in small-cell lung carcinoma cells.
Herpes Simplex
Use of H19 regulatory sequences for targeted gene therapy in cancer.
Herpes Simplex
Use of herpes simplex virus thymidine kinase to improve the antiviral activity of zidovudine.
Herpes Simplex
Use of isotopically chiral [4'-13C]penciclovir and 13C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1 and HSV-2 infected cells and by HSV-1-encoded thymidine kinase.
Herpes Simplex
Use of protamine to augment adenovirus-mediated cancer gene therapy.
Herpes Simplex
Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.
Herpes Simplex
Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro.
Herpes Simplex
Use of the mouse mammary tumor virus long terminal repeat to promote steroid-inducible expression of v-mos.
Herpes Simplex
Use of the polymerase chain reaction to detect herpes simplex virus DNA in paraffin sections of human brain at necropsy.
Herpes Simplex
Use of Thymidine Kinase Recombinant Adenovirus and Ganciclovir Mediated Mouse Liver Preconditioning for Hepatocyte Xenotransplantation.
Herpes Simplex
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Herpes Simplex
Use of TK-cells in haploidentical hematopoietic stem cell transplantation.
Herpes Simplex
Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumour-selective expression of a prodrug activating enzyme.
Herpes Simplex
Use of tumor-targeting trans-splicing ribozyme for cancer treatment.
Herpes Simplex
Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC.
Herpes Simplex
Use of [125I]deoxycytidine to detect herpes simplex virus-specific thymidine kinase in tissues of latently infected guinea pigs.
Herpes Simplex
Using HSV-thymidine kinase for safety in an allogeneic salivary graft cell line.
Herpes Simplex
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Herpes Simplex
Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus.
Herpes Simplex
Utilization of internal AUG codons for initiation of protein synthesis directed by mRNAs from normal and mutant genes encoding herpes simplex virus-specified thymidine kinase.
Herpes Simplex
Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma.
Herpes Simplex
UV cross-link mapping of the substrate-binding site of an RNase P ribozyme to a target mRNA sequence.
Herpes Simplex
Vaccinia virus encodes a thymidylate kinase gene: sequence and transcriptional mapping.
Herpes Simplex
Valproic acid enhances anti-tumor effect of mesenchymal stem cell mediated HSV-TK gene therapy in intracranial glioma.
Herpes Simplex
Variable expression of the herpes simplex virus thymidine kinase gene in Nicotiana tabacum affects negative selection.
Herpes Simplex
Variable responsiveness of hormone-inducible hybrid genes in different cell lines.
Herpes Simplex
Variations in transcription-repair coupling in mouse cells.
Herpes Simplex
Vascular damage and anti-angiogenic effects of tumor vessel-targeted adenovirus-mediated herpes simplex virus thymidine kinase gene.
Herpes Simplex
Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis.
Herpes Simplex
Verapamil enhances the efficiency of DNA-mediated gene transfer in mammalian cells.
Herpes Simplex
Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer.
Herpes Simplex
Viral therapies for glioblastoma and high-grade gliomas in adults: a systematic review.
Herpes Simplex
Viral-specific thymidine kinase in sensory ganglia of mice infected with herpes simplex virus.
Herpes Simplex
Virus specified enzyme activity and RNA species in herpes simplex virus type 1 transformed mouse cells.
Herpes Simplex
Virus type-specific thymidine kinase in cells biochemically transformed by herpes simplex virus types 1 and 2.
Herpes Simplex
Virus-free transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment induces tumor cell death.
Herpes Simplex
Virus-specific DNA sequences present in cells which carry the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Visualization of 5T33 myeloma cells in the C57BL/KaLwRij mouse: establishment of a new syngeneic murine model of multiple myeloma.
Herpes Simplex
VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death.
Herpes Simplex
VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment.
Herpes Simplex
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho.
Herpes Simplex
Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK.
Herpes Simplex
Yeast/herpes simplex virus thymidine kinase gene fusions yield fusion proteins with thymidine kinase activity.
Herpes Simplex
[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections.
Herpes Simplex
[125I]deoxycytidine used in a rapid, sensitive, and specific assay for herpes simplex virus type 1 thymidine kinase.
Herpes Simplex
[131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity.
Herpes Simplex
[A new paradigm of herpes simplex virus type 1 thymidine kinase (HSV-TK)/ganciclovir (GCV)]
Herpes Simplex
[Acyclovir in mycosis fungoides and lymphomatoid papulosis]
Herpes Simplex
[Adenovirus-mediated herpes simplex virus thymidine kinase gene transference and combined drug therapy leads to apoptosis of human epithelial ovarian cancer cells]
Herpes Simplex
[All-trans retinoic acid augments the bystander effect of herpes simplex virus thymidine kinase/ganciclovir system in the treatment of tongue carcinoma cell line]
Herpes Simplex
[Analysis of mutations in DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs]
Herpes Simplex
[Animal experiment on gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration in vivo]
Herpes Simplex
[Anti-proliferative effect of herpes simplex virus thymidine kinase gene system on human Tenon capsule fibroblasts in vitro]
Herpes Simplex
[Antiglioma activity of endothelial progenitor cells transduced with HSV-TK via inhibiting angiogenesis in vitro and in vivo.]
Herpes Simplex
[Autoradiography reporter gene (Ad5-tk carrying HSV1-tk gene) expression imaging in rat myocardium]
Herpes Simplex
[Biochemical evidence for integration of prokaryotic DNA into mammalian cells (author's transl)]
Herpes Simplex
[Chromosomal localization of foreign genes in transgenic mice using dual-color fluorescence in situ hybridization]
Herpes Simplex
[Cloning, expression, isolation and properties of thymidine kinase herpes simplex virus, strain L2].
Herpes Simplex
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
Herpes Simplex
[Comparative analysis of herpes simplex virus thymidine kinase gene expression potentiation via HIV-1 Tat-TAR-system and cancer-specific promoters in p53(+) and p53(-) cells]
Herpes Simplex
[Comparative study of the transformation of various thymidine kinase-deficient human and animal cell lines with the thymidine kinase gene of the Herpes simplex virus]
Herpes Simplex
[Construction and expression of hybrid genes based on a deletion mutant of the herpes virus thymidine kinase gene in Escherichia coli]
Herpes Simplex
[Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase genes expressed in vascular endothelial cells.]
Herpes Simplex
[Construction of a plasmid vector of fused protein genes driven by human insulin-like growth factor II P3 promoter]
Herpes Simplex
[Construction of universal vector for gene targeting and analysis of its function]
Herpes Simplex
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
Herpes Simplex
[Cys-Flanked Cationic Peptides For Cell Delivery of the Herpes Simplex Virus Thymidine Kinase Gene for Suicide Gene Therapy of Uterine Leiomyoma].
Herpes Simplex
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
Herpes Simplex
[Delivery of "suicide" thymidine kinase gene of herpes virus in the complex with cationic peptide into human hepatoma cells in vitro]
Herpes Simplex
[Different susceptibility of cell lines to thymidine kinase/ganciclovir-mediated killing effect and the way of cell death]
Herpes Simplex
[Double recombinants of the vaccinia virus expressing hepatitis B virus surface antigen and herpes simplex virus thymidine kinase]
Herpes Simplex
[Effect of pAdKDR-tk suicide gene system on tumor vascular endothelial cells in nude mice with nasopharyngeal carcinoma]
Herpes Simplex
[Effect of ultrasound microbubble carrying herpes simplex virus thymidine kinase on hepatocellular carcinoma in mice]
Herpes Simplex
[Effects of herpes simplex virus thymidine kinase gene transduction and prodrug on ovarian cancer cell]
Herpes Simplex
[Experimental studies on the characteristics of suicide gene system HSV-tk/GCV and its effect on dendritic cells]
Herpes Simplex
[Experimental treatment for human colorectal carcinoma by tissue type specific expression of herpes simplex virus thymidine kinase gene]
Herpes Simplex
[Expression in Chinese hamster transformant TK+-cells of the bacterial gene for beta-lactamase]
Herpes Simplex
[Expression of the radio-inducible TK suicide gene controlled by Egr-1 promoter in pancreatic cancer cells: an in vitro experiment]
Herpes Simplex
[Future directions of gene therapy for lung cancer]
Herpes Simplex
[Gene therapy for cancer]
Herpes Simplex
[Gene therapy for cerebral tumors: use of an adenovirus in the glioma C6 rat model]
Herpes Simplex
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
Herpes Simplex
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
Herpes Simplex
[Gene therapy of human pancreatic carcinoma by recombinant retroviral vector expressing herpes simplex virus thymidine kinase gene]
Herpes Simplex
[Gene therapy of primary cancers of the liver: hopes and realities]
Herpes Simplex
[Gene therapy using recombinant adenovirus carrying herpes simplex-thymidine kinase gene to treat mouse B 16 melanoma in vivo]
Herpes Simplex
[Gene therapy. A new prospect in the treatment of liver tumors]
Herpes Simplex
[Generation of a trans-complementable defective recombinant provirus and loading a transgene]
Herpes Simplex
[Genetic transformation of somatic cells. I. Clone of Chinese hamster cells defective in thymidine kinase and characterized by high transformation efficiency]
Herpes Simplex
[Genetic transformation of somatic cells. II. An analysis of the status of the plasmid nucleotide sequences in chromosomal DNA and the thymidine kinase activity in transformant clone cells]
Herpes Simplex
[Genetic transformation of somatic cells. III. An analysis of the status of the plasmid nucleotide sequences in the extrachromosomal DNA of transformant clone cells and the rescue of extrachromosomal molecules of the plasmid DNA]
Herpes Simplex
[Genetic transformation of somatic cells. IV. The rate of loss of transformant phenotype depends on the structure of the transforming DNA and changes when the cells are treated with the tumor promotor 12-o-tetradecanoyl-phorbol-13-acetate]
Herpes Simplex
[Genetic transformation of somatic cells. IX. The loss of the transformant phenotype is accompanied by rearrangements in the plasmid DNA containing the thymidine kinase gene of the herpes virus]
Herpes Simplex
[Genetic transformation of somatic cells. V. Inheritability of the rate of loss of the trait and the stabilization of the transformant phenotype]
Herpes Simplex
[Genetic transformation of somatic cells. VI. Transfer of the trait of the rate of loss of transformant phenotype by means of DNA from cells containing the thymidine kinase gene of the herpes simplex virus]
Herpes Simplex
[Genetic transformation of somatic cells. VII. The loss of the transformant phenotype is accompanied by both stable and unstable changes in DNA]
Herpes Simplex
[Genetic transformation of somatic cells. VIII. The effect of the DNA methylation inhibitor 5-azacytidine on the stability of thymidine kinase-negative and -positive phenotypes of transformant clone cells]
Herpes Simplex
[Hypoxia augments the killing effect of herpes simplex virus thymidine kinase gene expression actuated by the promoter of the vascular endothelial growth factor gene on human hepatocellular tumor cells]
Herpes Simplex
[In vitro and in vivo bystander effect of adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene]
Herpes Simplex
[In vitro experimental study of gene therapy for ovarian cancer with thymidine kinase gene of herpes simplex virus mediated by a non-viral GE7 delivery system]
Herpes Simplex
[In vitro killing effect of mutant thymidine kinase mediated by lentiviral vector on T lymphocytes]
Herpes Simplex
[Inhibition of the reproduction of a herpes simplex I virus carrying mutations in the thymidine kinase and DNA polymerase genes]
Herpes Simplex
[Inhibitory effect of ganciclovir on the HSV1-tk positive subcutaneous tumors transplanted with human ovarian cancer in nude mice]
Herpes Simplex
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
Herpes Simplex
[Killing effect of adenovirus vector-mediated herpes simplex virus thymidine kinase gene recombinant construct on various cancer cells]
Herpes Simplex
[Long-term and stable expression of transgene mediated by piggyBac transposon in gynecological malignant tumor cells].
Herpes Simplex
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
Herpes Simplex
[Molecular genetics of the Herpes simplex viruses: physical and functional mapping of a new syncytial locus in the region coding thymidine kinase and glycoprotein H]
Herpes Simplex
[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others]
Herpes Simplex
[Prospect of gene therapy for metastatic foci of gastric cancer]
Herpes Simplex
[Prospects and current data in antiviral chemotherapy]
Herpes Simplex
[Recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene transfer followed by ganiciclovir administration effectively inhibits growth of human small-cell lung cancer in a murine xenotransplant model]
Herpes Simplex
[Selective gene therapy of malignant gliomas using brain-specific promoters: its efficacy and basic investigations]
Herpes Simplex
[Sensitivities to other antiviral drugs and thymidine kinase activity of aciclovir-resistant herpes simplex virus type 1]
Herpes Simplex
[Specific activity of the promoter containing Myc-Max response elements in c-myc-overexpressing cells]
Herpes Simplex
[Structure-activity relation study of anti-herpes associations with a 2'-deoxyuridine basic structure]
Herpes Simplex
[Studies on herpes simplex virus thymidine kinase gene and GCV system for treatment of human bladder carcinoma]
Herpes Simplex
[Studies on thymidine kinase gene (TK) and GCV system for treatment of human retinoblastoma (RB)]
Herpes Simplex
[Study on cotransfection of genes of insulin-like growth factor I and herpes simplex virus thymidine kinase for optimization of wound healing]
Herpes Simplex
[Synergistic effect of all-trans retinoic acid and herpes simplex virus thymidine kinase gene on glioma]
Herpes Simplex
[Targeted killing effect of mucin-1 single chain antibody targeting, lentivirus-mediated suicide gene therapy and ganciclovir in mucin-1+ ovarian epithelial carcinoma cells]
Herpes Simplex
[The adenovirus-mediated HSV-TK/GCV suicide gene system in the treatment of tongue carcinoma cell line]
Herpes Simplex
[The effect of HSV-tk/GCV on hepatic specific damage driven by murine ALB promoter/enhancer]
Herpes Simplex
[The effects of HSV-tk suicide gene and wild-type p53 gene on pleomorphic adenoma cells of salivary gland]
Herpes Simplex
[The killing effects of two prodrug sensitivity genes on human pancreatic carcinoma cells PC-2]
Herpes Simplex
[The mechanism of bystander effect in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy]
Herpes Simplex
[Therapeutic effect of ovarian intra-arterial infusion of GE7-delivery system-mediated HSVl-tk/ganciclovir gene therapy in a rat model of malignant ovarian tumor].
Herpes Simplex
[Transfer of thymidine kinase gene of herpes simplex virus mediated by retrovirus vector into ovarian cancer cells]
Herpes Simplex
[Treatment of experimental liver tumors by in vivo suicide gene transfer in rats]
Herpes Simplex
[Utilization of herpes simplex virus-1 thymidine kinase gene in stem cell transplantation therapy]
Herpes Simplex
[Vesicular stomatitis virus G-protein retrovector mediated a herpes simplex virus thymidine kinase gene transduction and expression in the human retinal pigment epithelial cells]
Herpes Zoster
Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine.
Herpes Zoster
Antibody responses to early antigens of varicella-zoster virus (VZV) during varicella and zoster.
Herpes Zoster
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.
Herpes Zoster
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects.
Herpes Zoster
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Herpes Zoster
Compartmentalization of acyclovir-resistant varicella zoster virus: implications for sampling in molecular diagnostics.
Herpes Zoster
Crystal structure of varicella zoster virus thymidine kinase.
Herpes Zoster
Development of canine herpesvirus based antifertility vaccines for foxes using bacterial artificial chromosomes.
Herpes Zoster
Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy.
Herpes Zoster
Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants.
Herpes Zoster
Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome.
Herpes Zoster
Foscarnet salvage therapy for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of the literature.
Herpes Zoster
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Herpes Zoster
Highly purified recombinant varicella Zoster virus thymidine kinase is a homodimer.
Herpes Zoster
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
Herpes Zoster
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Herpes Zoster
Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an in-silico approach.
Herpes Zoster
In-vitro synthesis of functional varicella zoster and herpes simplex viral thymidine kinase.
Herpes Zoster
Metabolic suicide genes in gene therapy.
Herpes Zoster
Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.
Herpes Zoster
Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Herpes Zoster
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Herpes Zoster
Rapid sampling of multiple enzyme reactions.
Herpes Zoster
Regulated expression of artificial chimeric genes contained in retroviral vectors: implications for virus-directed enzyme prodrug therapy (VDEPT) and other gene therapy applications.
Herpes Zoster
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.
Herpes Zoster
Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.
Herpes Zoster
The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.
Herpes Zoster
The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility.
Herpes Zoster
The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
Herpes Zoster
Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62.
Herpes Zoster
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
Herpes Zoster
[Expression of the varicella zoster virus thymidine kinase and cytokines in patients with acute retinal necrosis syndrome]
Herpesviridae Infections
Atypical Presentation of Herpes Simplex Virus Type 2 Infection Refractory to Treatment With Acyclovir in 2 Hematologic Patients.
Herpesviridae Infections
Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase.
Herpesviridae Infections
Epstein--Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate.
Herpesviridae Infections
Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies.
Herpesviridae Infections
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
Herpesviridae Infections
Thymidine kinase not required for antiviral activity of acyclovir against mouse cytomegalovirus.
HIV Infections
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects.
HIV Infections
Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.
HIV Infections
Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population.
HIV Infections
Serum thymidine kinase (TK) evaluation in HIV infection.
HIV Infections
Thymidine kinase and deoxycytidine kinase in HIV-infected children.
Hodgkin Disease
Enzymes as prognostic markers and therapeutic indicators in patients with cancer.
Hodgkin Disease
Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma.
Hodgkin Disease
Serum thymidine kinase as a prognostic marker in Hodgkin's disease.
Hodgkin Disease
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Hydatidiform Mole
[Changes in gene expression profiles of hydatidiform mole and choriocarcinoma as compared with trophoblast hyperplasia]
Hypergammaglobulinemia
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Hyperglycemia
Multimodality Imaging of {beta}-Cells in Mouse Models of Type I and II Diabetes.
Hyperprolactinemia
Does hyperprolactinemia affect hepatic regeneration independent of sex steroids?
Hypersensitivity
Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells
Hypersensitivity
Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.
Hypersensitivity
The structure of the thymidine kinase gene promoter: nuclease hypersensitivity correlates with expression.
Hypertension, Portal
Effect of partial portal vein ligation on hepatic regeneration.
Hyperthyroidism
Thymidine kinase activity in homogenates of rat thyroid lobes from euthyroid, hypothyroid and/or hyperthyroid rats incubated with EGF: studies ex vivo in vitro.
Hyperthyroidism
Thyroxine effect upon activity of uridine kinase in developing rat cerebellum.
Hyperthyroidism
Thyroxine injections do not cause premature induction of thymidine kinase in sg/sg mice.
Hypothyroidism
Effects of hypothyroidism and undernutrition on DNA content and thymidine kinase activity during cerebellar development in the rat.
Infarction, Middle Cerebral Artery
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.
Infections
3,19-isopropylideneandrographolide suppresses early gene expression of drug-resistant and wild type herpes simplex viruses.
Infections
A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.
Infections
A new cell-based assay for measuring the forward mutation rate of HIV-1.
Infections
A Novel Thyroid Hormone Mediated Regulation of HSV-1 Gene Expression and Replication is Specific to Neuronal Cells and Associated with Disruption of Chromatin Condensation.
Infections
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
Infections
Activation of gene expression by human herpesvirus 6 is reporter gene-dependent.
Infections
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
Infections
Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population.
Infections
Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo.
Infections
Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.
Infections
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
Infections
Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery.
Infections
Advances in the treatment of varicella-zoster virus infections.
Infections
Altered properties of thymidine kinase after infection of mouse fibroblast cells with herpes simplex virus.
Infections
Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.
Infections
Analysis of deoxycytidine (dC) deaminase activity in herpes simplex virus-infected or HSV TK-transformed cells: association with mycoplasma contamination but not with virus infection.
Infections
Antibody-Directed Double Suicide Gene Therapy Targeting of MUC1-Positive Leukemia Cells in Vitro and in Vivo.
Infections
Attenuated marmoset herpesvirus isolated from recombinants of virulent marmoset herpesvirus and hybrid plasmids.
Infections
Autopsy findings in two cases of neonatal herpes simplex virus infection: detection of virus by immunohistochemistry, in situ hybridization and the polymerase chain reaction.
Infections
Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity.
Infections
Biochemical characterization of a virus isolate, recovered from a patient with herpes keratitis, that was clinically resistant to acyclovir.
Infections
Biochemical transformation of mouse cells by fragments of herpes simplex virus DNA.
Infections
Comparative transcriptome analysis reveals resistance-related genes and pathways in Musa acuminata banana 'Guijiao 9' in response to Fusarium wilt.
Infections
Comparison of thymidine kinase activities indiced in cells productively infected with herpesvirus saimiri and herpes simplex virus.
Infections
Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection.
Infections
Consequences of herpes simplex virus type 2 and human cell interaction at supraoptimal temperatures.
Infections
Control of expression of the vaccinia virus thymidine kinase gene.
Infections
Control of thymidine kinase synthesis in IHD vaccinia virus-infected thymidine kinase-deficient LM cells.
Infections
Correlation of the virus sequence content and biological properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene.
Infections
Delineation of regulatory domains of early (beta) and late (gamma 2) genes by construction of chimeric genes expressed in herpes simplex virus 1 genomes.
Infections
Deoxyribonucleoside triphosphate pools in herpes simplex type 1 infected cells.
Infections
Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients.
Infections
Detection of immediate early protein ICP27/IE63 and thymidine kinase in the course of reactivation of latent herpes simplex virus 1 infection.
Infections
Detection of viral DNA in neonatal herpes encephalitis autopsy tissues by solution-phase PCR: comparison with pathology and immunohistochemistry.
Infections
Due to low infection rates no routine anti-infective prophylaxis is required in younger patients with chronic lymphocytic leukaemia during fludarabine-based first line therapy.
Infections
Ectopic expression of DNA encoding IFN-alpha 1 in the cornea protects mice from herpes simplex virus type 1-induced encephalitis.
Infections
Efficacy of 2'-nor-cyclicGMP in treatment of experimental herpes virus infections.
Infections
Efficacy of Cafon gel on cutaneous infection with herpes simplex virus (HSV)-2 and acyclovir-resistant HSV in mice.
Infections
Emerging drugs for varicella-zoster virus infections.
Infections
Enhanced thymidine kinase activity following infection of green monkey kidney cells by simian adenoviruses, simian papovavirus SV40, and an adenovirus-SV40 "hybrid".
Infections
Enhancement of the thymidine kinase activity of human embryonic kidney cells and newborn hamster kidney cells by infection with human adenovirus types 5 and 12.
Infections
Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells.
Infections
Equine herpesvirus 1 glycoprotein D: mapping of the transcript and a neutralization epitope.
Infections
Evaluation of Musculoskeletal and Pulmonary Bacterial Infections With [124I]FIAU PET/CT.
Infections
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Infections
Experimental infection of pigs with a thymidine kinase negative strain of pseudorabies virus.
Infections
Expression of African swine fever virus envelope protein j13L inhibits vaccinia virus morphogenesis.
Infections
Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay.
Infections
Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes.
Infections
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.
Infections
Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging.
Infections
Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors.
Infections
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Infections
Hepatoma-specific gene therapy through retrovirus-mediated and targeted gene transfer using an adenovirus carrying the ecotropic receptor gene.
Infections
Herpes simplex type 1 infects and establishes latency in the brain and trigeminal ganglia during primary infection of the lip in cotton rats and mice.
Infections
Herpes Simplex Virus 1 Reactivates from Autonomic Ciliary Ganglia Independently from Sensory Trigeminal Ganglia To Cause Recurrent Ocular Disease.
Infections
Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus.
Infections
Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.
Infections
Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation.
Infections
Herpes simplex virus thymidine kinase transcripts are absent from both nucleus and cytoplasm during infection in the presence of cycloheximide.
Infections
Human cytomegalovirus replicates in gamma-irradiated fibroblasts.
Infections
Impact of chronic protein-calorie malnutrition on small intestinal repair after acute viral enteritis: a study in gnotobiotic piglets.
Infections
In vivo function of the Murid Herpesvirus-4 ribonucleotide reductase small subunit.
Infections
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Infections
Induction capacity and influence of dThdMP on thymidine kinase activity of type 1 and 2 strains of herpes simplex virus.
Infections
Influence of dibutyryl cyclic AMP on thymidine uptake by herpes simplex virus infected cells and the intracellular level of cyclic AMP.
Infections
Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus.
Infections
Inhibition by interferon of herpes simplex virus thymidine kinase and DNA polymerase in infected and biochemically transformed cells.
Infections
Inhibition of HSV-1 multiplication in rat embryo fibroblasts constitutively expressing the EJ-ras oncogene.
Infections
Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo.
Infections
Intestinal enzyme profiles in normal and rotavirus-infected mice.
Infections
Isolation of a novel fish thymidylate kinase gene, upregulated in Atlantic salmon (Salmo salar L.) following infection with the monogenean parasite Gyrodactylus salaris.
Infections
Isolation of mutants of bacteriophage T4 unable to induce thymidine kinase activity. II. Location of the structural gene for thymidine kinase.
Infections
Long-term observation of herpes simplex virus type 1 (HSV-1) infection in a child with Wiskott-Aldrich syndrome and a possible reactivation mechanism for thymidine kinase-negative HSV-1 in humans.
Infections
Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants.
Infections
Mechanism of resistance to acyclovir in thymidine kinase mutants from Herpes simplex virus type 1: a computational approach.
Infections
Molecular Imaging of Cardiovascular Device Infection: Targeting the Bacteria or the Host-Pathogen Immune Response?
Infections
Multiplicity reactivation and mutagenesis of trimethylpsoralen-damaged herpes virus in normal and Fanconi's anaemia cells.
Infections
Mutant of herpes simplex virus type 1 conditionally able to transform thymidine kinaseless L cells to a tk+ phenotype.
Infections
Mutational analysis of the ICP4 binding sites in the 5' transcribed noncoding domains of the herpes simplex virus 1 UL 49.5 gamma 2 gene.
Infections
Mycobacterium tuberculosis thymidylate kinase antigen assays for designating incipient, high-risk latent M.tb infection.
Infections
Negative regulation of herpes simplex virus type 1 ICP4 promoter by IE180 protein of pseudorabies virus.
Infections
Negative regulation of resistance protein-mediated immunity by master transcription factors SARD1 and CBP60g.
Infections
Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.
Infections
Neural spread of herpes simplex virus after anterior chamber inoculation.
Infections
Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
Infections
Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient.
Infections
Nucleic acid related compounds. 65. New syntheses of 1-(beta-D-arabinofuranosyl)-5(E)-(2-iodovinyl)uracil (IVAraU) from vinylsilane precursors. Radioiodine uptake as a marker for thymidine kinase positive herpes viral infections.
Infections
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Infections
Pathogenesis of acyclovir-resistant herpes simplex type 2 isolates in animal models of genital herpes: models for antiviral evaluations.
Infections
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Infections
Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues.
Infections
Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model.
Infections
Protection against Leishmania major challenge infection in mice vaccinated with live recombinant parasites expressing a cytotoxic gene.
Infections
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.
Infections
Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion.
Infections
Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development.
Infections
Recurrent aciclovir-resistant herpes simplex in a child with Wiskott-Aldrich syndrome.
Infections
Replication of human cytomegalovirus in human retinal glial cells.
Infections
Replication of thymidine kinase deficient herpes simplex virus type 1 in neuronal cell culture: infection of the PC 12 cell.
Infections
Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.
Infections
Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity.
Infections
Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.
Infections
Retroviral interleukin 4 gene transfer into an interleukin 4-dependent cell line results in autocrine growth but not in tumorigenicity.
Infections
Reverse transcriptase and thymidine kinase as markers for tumorigenicity and viral contamination of cells.
Infections
Role of the DR2 repeat array in the regulation of the ICP34.5 gene promoter of herpes simplex virus type 1 during productive infection.
Infections
Selective induction of chromosomal gene expression by human cytomegalovirus.
Infections
Sexual Dimorphism in Hepatocyte Xenograft Models.
Infections
Stimulation of human cellular thymidine kinase activity during abortive infection with herpes simplex virus type 2.
Infections
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes.
Infections
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
Infections
Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus.
Infections
Syntheses of virus-induced thymidine kinase and viral DNA in herpes simplex type 1 virus-infected chick embryo fibroblasts.
Infections
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
Infections
T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: comparison of four different infection protocols.
Infections
TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.
Infections
Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
Infections
The expression of P-glycoprotein and cellular kinases is modulated at the transcriptional level by infection and highly active antiretroviral therapy in a primate model of AIDS.
Infections
The replication of viral and cellular DNA in human herpesvirus 6-infected cells.
Infections
The role of pseudorabies virus thymidine kinase expression in trigeminal ganglion infection.
Infections
The zinc ring finger in the bICP0 protein encoded by bovine herpesvirus-1 mediates toxicity and activates productive infection.
Infections
Therapeutic efficacy of DNA encoding IFN-alpha1 against corneal HSV-1 infection.
Infections
Thymidine kinase (TK) induction after infection of TK-deficient rabbit cell mutants with bovine herpesvirus type 1 (BHV-1): isolation of TK- BHV-1 mutants.
Infections
Thymidine kinase gene transfer by herpes simplex virus.
Infections
Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter.
Infections
Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus.
Infections
Transmissible gastroenteritis: sodium transport and the intestinal epithelium during the course of viral enteritis.
Infections
Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus.
Infections
Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammlian cells.
Infections
Virus specified enzyme activity and RNA species in herpes simplex virus type 1 transformed mouse cells.
Infections
[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections.
Infections
[(125)I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load.
Infections
[Acyclovir-resistant perineal HSV infection revealing chronic lymphoid leukaemia].
Infections
[Chemotherapy to thymidine kinase producing virus (HSV-1, HSV-2, VZV) infection]
Infections
[Evaluation of the effect of early and massive tritherapy on the expression of cellular factors potentially implicated in antiretroviral therapy resistance]
Infections
[Mother-infant and indirect transmission of HSV infection: treatment and prevention]
Infectious Bovine Rhinotracheitis
Attenuation of bovine herpesvirus type 1 by deletion of its glycoprotein G and tk genes and protection against virulent viral challenge.
Infectious Bovine Rhinotracheitis
Identification of the thymidine kinase gene of infectious bovine rhinotracheitis virus and its function in Escherichia coli hosts.
Infectious Mononucleosis
Relationship between nasopharyngeal carcinoma and high antibody titers to Epstein-Barr virus-specific thymidine kinase.
Infertility
A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.
Infertility
Flagellar and acrosomal abnormalities associated with testicular HSV-tk expression in the mouse.
Infertility
Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.
Infertility
Herpesvirus thymidine kinase transgenes that do not cause male sterility are aberrantly transcribed and translated in the testis.
Infertility
Presence of human herpes virus 1-thymidine kinase in testis of azoospermic infertile herpes-infected patients.
Infertility
Recovery of myelin after induction of oligodendrocyte cell death in postnatal brain.
Infertility, Male
Accumulated HSV1-TK Proteins Interfere with Spermatogenesis Through a Disruption of the Integrity of Sertoli-Germ Cell Junctions.
Infertility, Male
Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients.
Infertility, Male
Generation of transgenic rats with YACs and BACs: preparation procedures and integrity of microinjected DNA.
Infertility, Male
Herpesvirus thymidine kinase transgenes that do not cause male sterility are aberrantly transcribed and translated in the testis.
Infertility, Male
HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells.
Infertility, Male
Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
Influenza in Birds
Expression of avian influenza virus hemagglutinin by recombinant fowlpox virus.
Influenza, Human
[Advances in antiviral chemotherapy]
Insulinoma
Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region.
Keratitis
A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits.
Keratitis
A thymidine kinase deficient HSV-2 strain causes acute keratitis and establishes trigeminal ganglionic latency, but poorly reactivates in vivo.
Keratitis
Acyclovir-resistant bilateral keratitis associated with mutations in the HSV-1 thymidine kinase gene.
Keratitis
Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.
Keratitis
Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient.
Keratitis
HSV-1 thymidine kinase negative vaccine: pathogenicity, protection, and perils.
Keratitis, Herpetic
Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient.
Keratitis, Herpetic
Effect of 9-(4-hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, on clinical recurrences of ocular herpetic keratitis in squirrel monkeys.
Keratitis, Herpetic
Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools.
Keratitis, Herpetic
Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains.
Keratitis, Herpetic
Thymidine kinase activity of ocular herpes simplex isolates resistant to IUDR therapy.
Kidney Diseases
Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.
Latent Infection
Acute and latent infection by thymidine kinase mutants of herpes simplex virus type 2.
Latent Infection
Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.
Latent Infection
Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Latent Infection
Investigation of the mechanism by which herpes simplex virus type 1 LAT sequences modulate preferential establishment of latent infection in mouse trigeminal ganglia.
Latent Infection
Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus.
Latent Infection
Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.
Latent Infection
Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.
Latent Infection
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Latent Infection
Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
Leiomyoma
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Leiomyoma
Towards Fibroid Gene Therapy: Adenovirus-Mediated Delivery of Herpes Simplex Virus 1 Thymidine Kinase Gene/Ganciclovir Shrinks Uterine Leiomyoma in the Eker Rat Model.
Leukemia
A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.
Leukemia
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103.
Leukemia
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene.
Leukemia
Antibody-Directed Double Suicide Gene Therapy Targeting of MUC1-Positive Leukemia Cells in Vitro and in Vivo.
Leukemia
Antitumor effects of cytosine deaminase and thymidine kinase fusion suicide gene under the control of mdr1 promoter in mdr1 positive leukemia cells.
Leukemia
Bromodeoxyuridine resistance: thymidine transport and phosphorylation in Friend leukemia cells.
Leukemia
Cerebro-spinal fluid thymidine kinase in acute leukemia.
Leukemia
Changes of serum thymidine kinase in children with acute leukemia.
Leukemia
Construction of a mammalian transducing vector from the genome of Moloney murine leukemia virus.
Leukemia
Cure of mice with established metastatic friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-alpha 1 and herpes simplex thymidine kinase followed by ganciclovir.
Leukemia
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
Leukemia
Deoxycytidine and deoxythymidine kinase activities in plasma of mice and patients with neoplastic disease.
Leukemia
Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene.
Leukemia
Different effect of thymidine kinase loss on TTP pools; comparison among human leukemia cell lines.
Leukemia
DNA-mediated gene transfer in Friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA.
Leukemia
Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.
Leukemia
Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
Leukemia
Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation.
Leukemia
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase--ganciclovir treatment.
Leukemia
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Leukemia
Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1.
Leukemia
Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.
Leukemia
In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model.
Leukemia
Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase.
Leukemia
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
Leukemia
Influence of different promoters on the expression of tumor-necrosis-factor-alpha in ls174t human colon-carcinoma cells.
Leukemia
Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene.
Leukemia
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Leukemia
Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity--evaluation of a new, fully automated non-radiometric assay.
Leukemia
Overexpression of human thymidine kinase mRNA without corresponding enzymatic activity in patients with chronic lymphatic leukemia.
Leukemia
Plasma thymidine kinase activity in dogs with lymphoma and leukemia.
Leukemia
Pleiotropic expression of heterologous cytokine/receptor genes in HTLV-1 associated diseases: candidate TRS for chimeric gene therapy.
Leukemia
Retroviral vector gene expression in F9 embryonal carcinoma cells.
Leukemia
Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events.
Leukemia
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Leukemia
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease.
Leukemia
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Leukemia
Serum thymidine kinase in acute nonlymphoblastic leukemia.
Leukemia
Serum thymidine kinase in hairy cell leukemia before and during treatment with alpha interferon.
Leukemia
Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line.
Leukemia
Somatic hybrid of thymus leukemia (.
Leukemia
Structural characteristics of cationic liposomes with potent enhancing effect on retroviral transduction into human hepatoma cells.
Leukemia
Synthesis and antineoplastic activity of some cyano-, carboxy-, carbomethoxy-, and carbamoylborane adducts of heterocyclic amines.
Leukemia
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
Leukemia
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Leukemia
The role of p16 in the E2F-dependent thymidine kinase regulation.
Leukemia
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
Leukemia
Thymidine kinase as a determinant of the response to 5-fluoro-2'-deoxyuridine in transplantable murine leukemias.
Leukemia
Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents.
Leukemia
Thymidine kinase in human leukemia. Expression of the lymphoblastic isoenzyme in three patients with acute myelocytic leukemia.
Leukemia
Thymidine kinase isoenzymes in human acute and chronic lymphatic leukemia.
Leukemia
Thymidine kinase isoenzymes in human acute monocytic leukemia.
Leukemia
Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm.
Leukemia
Thymidine Kinase: A Biomarker for Recently Diagnosed Acute Leukemia in Pediatric Patients According to the Cell Line Involved.
Leukemia
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
Leukemia
Transgene amplification and persistence after delivery of retroviral vector and packaging functions with E1/E4-deleted adenoviruses.
Leukemia
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.
Leukemia
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
Leukemia
[Clinical application of thymidine kinase activity in patients with acute non-lymphocytic leukemia]
Leukemia
[Determination of thymidine kinase in the cerebrospinal fluid as a marker of leukemic meningosis]
Leukemia
[Generation of a trans-complementable defective recombinant provirus and loading a transgene]
Leukemia L1210
Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines.
Leukemia L1210
[Biochemical mechanisms of resistance to a new antineoplastic drug CRC 680578 from the nitrosourea class]
Leukemia P388
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
Leukemia P388
[Changes in the activity of thymidine kinase, ribonucleotide reductase and DNA-polymerases during the development of leukemia P388 in mice]
Leukemia, Erythroblastic, Acute
Arabinose furanosyl thymidine: uptake, phosphorylation and incorporation into DNA of mammalian cells.
Leukemia, Erythroblastic, Acute
Azacytidine induces reversion of thymidine kinase deficiency in Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Differential expression of mouse beta/goat beta c, mouse beta/goat beta F, and mouse beta/goat epsilon II hybrid globin genes in murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Effect of a dCTP:dTTP pool imbalance on DNA replication fidelity in Friend murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter.
Leukemia, Hairy Cell
Serum thymidine kinase in hairy cell leukemia before and during treatment with alpha interferon.
Leukemia, Lymphocytic, Chronic, B-Cell
Deoxynucleoside anabolic enzyme levels in acute myelocytic leukemia and chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
High serum thymidine kinase 1 level predicts poorer survival in patients with chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Overexpression of human thymidine kinase mRNA without corresponding enzymatic activity in patients with chronic lymphatic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Prognostic value of thymidine kinase activity in patients with chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma.
Leukemia, Lymphocytic, Chronic, B-Cell
Serum deoxythymidine kinase correlates with peripheral lymphocyte thymidine uptake in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Serum thymidine kinase 1 concentration in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors.
Leukemia, Lymphocytic, Chronic, B-Cell
Serum thymidine kinase activity: analytical performance, age-related reference ranges and validation in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Thymidine kinase isoenzymes in human acute and chronic lymphatic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Unavailability of thymidine kinase does not preclude the use of German comprehensive prognostic index: results of an external validation analysis in early chronic lymphocytic leukemia and comparison with MD Anderson Cancer Center model.
Leukemia, Lymphocytic, Chronic, B-Cell
[Lipoprotein lipase and serum thymidine kinase level in chronic lymphocytic leukemia and their correlations with other prognostic factors]
Leukemia, Lymphoid
Cytotoxicity of rhenium(I) alkoxo and hydroxo carbonyl complexes in murine and human tumor cells.
Leukemia, Monocytic, Acute
Thymidine kinase isoenzymes in human acute monocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Comparison of cell-labeling methods with ¹²?I-FIAU and ??Cu-PTSM for cell tracking using chronic myelogenous leukemia cells expressing HSV1-tk and firefly luciferase.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Thymidine kinase in human leukemia--expression of three isoenzyme variants in six patients with chronic myelocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Thymidine kinase activity in leukocytes from patients with chronic myeloid leukemia at various periods in the disease]
Leukemia, Myeloid
Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.
Leukemia, Myeloid
The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells.
Leukemia, Myeloid
Thymidine kinase from blast cells of myelocytic leukemia.
Leukemia, Myeloid
Thymidine kinase in human leukemia. Expression of the lymphoblastic isoenzyme in three patients with acute myelocytic leukemia.
Leukemia, Myeloid, Acute
Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Deoxynucleoside anabolic enzyme levels in acute myelocytic leukemia and chronic lymphocytic leukemia cells.
Leukemia, Myeloid, Acute
Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments.
Leukemia, Myeloid, Acute
Inhibition of adenosine and thymidylate kinases by bisubstrate analogs.
Leukemia, Myeloid, Acute
Inhibition of thymidine kinase by P1-(adenosine-5')-P5-(thymidine-5')-pentaphosphate.
Leukemia, Myeloid, Acute
Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.
Leukemia, Myeloid, Acute
Serum thymidine kinase in acute nonlymphoblastic leukemia.
Leukemia, Myeloid, Acute
Thymidine kinase in human leukemia. Expression of the lymphoblastic isoenzyme in three patients with acute myelocytic leukemia.
Leukemia, Promyelocytic, Acute
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Leukemia, T-Cell
An efficient expression vector for stable expression in human liver cells.
Leukemia, T-Cell
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein.
Leukemia, T-Cell
Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1.
Leukemia, T-Cell
In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model.
Leukemia-Lymphoma, Adult T-Cell
Cytomegalovirus infection is not necessarily a poor prognostic factor in adult T-cell leukemia/lymphoma.
Lipoma
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Liver Cirrhosis
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus.
Liver Diseases
[Serum thymidine kinase activity of various cancer and HBV positive liver diseases]
Liver Failure
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
Liver Failure
Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat.
Liver Failure
Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion.
Liver Neoplasms
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme.
Liver Neoplasms
Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma.
Liver Neoplasms
Evolutionary cancer-favoring engineered vaccinia virus for metastatic hepatocellular carcinoma.
Liver Neoplasms
Preclinical Safety Evaluation of 18F-FHBG: A PET Reporter Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1-tk) or Mutant HSV1-sr39tk's Expression.
Liver Neoplasms
Serum AFU, GGT and TK1 levels in PHC patients and their correlation with clinicopathology and diagnostic value.
Liver Neoplasms
Suicide gene therapy for urogenital cancer: current outcome and prospects.
Liver Neoplasms
Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA.
Liver Neoplasms, Experimental
5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
Liver Neoplasms, Experimental
Comparison of [(14)C]FMAU, [(3)H]FEAU, [(14)C]FIAU, and [(3)H]PCV for Monitoring Reporter Gene Expression of Wild Type and Mutant Herpes Simplex Virus Type 1 Thymidine Kinase in Cell Culture.
Liver Neoplasms, Experimental
Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro.
Liver Neoplasms, Experimental
Glucose transport and apoptosis after gene therapy with HSV thymidine kinase.
Liver Neoplasms, Experimental
Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone.
Liver Neoplasms, Experimental
Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells.
Liver Neoplasms, Experimental
Tumor-associated thymidine kinase in the sera of rats with transplanted hepatomas.
Lumpy Skin Disease
Immune responses to recombinants of the South African vaccine strain of lumpy skin disease virus generated by using thymidine kinase gene insertion.
Lumpy Skin Disease
Importance of thymidine kinase activity for normal growth of lumpy skin disease virus (SA-Neethling).
Lumpy Skin Disease
Protection of Cattle Elicited Using a Bivalent Lumpy Skin Disease Virus-Vectored Recombinant Rift Valley Fever Vaccine.
Lung Diseases
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Lung Neoplasms
Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model.
Lung Neoplasms
Clinical and serologic markers of stage and prognosis in small cell lung cancer. A multivariate analysis.
Lung Neoplasms
Clinical relevance of thymidine kinase for the diagnosis, therapy monitoring and prognosis of non-operable lung cancer.
Lung Neoplasms
Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase.
Lung Neoplasms
Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer.
Lung Neoplasms
Correlation between serum tumor marker levels and tumor proliferation in small cell lung cancer.
Lung Neoplasms
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Lung Neoplasms
Ectopic expression of herpes simplex virus-thymidine kinase gene in human non-small cell lung cancer cells conferred caspase-activated apoptosis sensitized by ganciclovir.
Lung Neoplasms
Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
Lung Neoplasms
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Lung Neoplasms
Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer.
Lung Neoplasms
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Lung Neoplasms
Gene therapy with GM-CSF, interleukin-4 and herpes simplex virus thymidine kinase shows strong antitumor effect on lung cancer.
Lung Neoplasms
Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors.
Lung Neoplasms
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.
Lung Neoplasms
Neuron-specific enolase and thymidine kinase as an aid to the diagnosis and treatment monitoring of small cell lung cancer.
Lung Neoplasms
Neuron-specific enolase, thymidine kinase, and tissue polypeptide-specific antigen in diagnosis and response to chemotherapy of small-cell lung cancer.
Lung Neoplasms
Non-Small-Cell Lung Cancer: Feasibility of Intratumoral Radiofrequency Hyperthermia-enhanced Herpes Simplex Virus Thymidine Kinase Gene Therapy.
Lung Neoplasms
Prognostic value of serum thymidine kinase, tissue polypeptide antigen and neuron specific enolase in patients with small cell lung cancer.
Lung Neoplasms
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Lung Neoplasms
Selective killing of lung cancer cells using carcinoembryonic antigen promoter and double suicide genes, thymidine kinase and cytosine deaminase (pCEA-TK/CD).
Lung Neoplasms
Serum detection of thymidine kinase 1 as a means of early detection of lung cancer.
Lung Neoplasms
Serum thymidine kinase 1 activity in the prognosis and monitoring of chemotherapy in lung cancer patients: a brief report.
Lung Neoplasms
Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer.
Lung Neoplasms
Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer.
Lung Neoplasms
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Lung Neoplasms
Study on the effect of BMSCs-EGFP-tk as mediator of HSV1-tk/GCV suicide gene therapy directed against A549 in vitro.
Lung Neoplasms
Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Lung Neoplasms
The Half-Life of Serum Thymidine Kinase 1 Concentration Is an Important Tool for Monitoring Surgical Response in Patients with Lung Cancer: A Meta-Analysis.
Lung Neoplasms
Thymidine kinase 1 combined with CEA, CYFRA21-1 and NSE improved its diagnostic value for lung cancer.
Lung Neoplasms
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Lung Neoplasms
Transcriptionally targeted in vivo gene therapy for carcinoembrionic antigen-producing adenocarcinoma.
Lung Neoplasms
XPA-210: a new proliferation marker to characterize tumor biology and progression of renal cell carcinoma.
Lung Neoplasms
[A study of thymidine kinase activity in lung cancer tissue]
Lung Neoplasms
[Future directions of gene therapy for lung cancer]
Lung Neoplasms
[Recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene transfer followed by ganiciclovir administration effectively inhibits growth of human small-cell lung cancer in a murine xenotransplant model]
Lymphadenopathy
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Lymphatic Metastasis
Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.
Lymphocytosis
Calf Form Bovine Leukosis with Lameness in a Holstein Heifer.
Lymphocytosis
Serum thymidine kinase activity as a useful marker for bovine leukosis.
Lymphocytosis
[Mantle cell lymphoma as a diagnostic and therapeutic problem]
Lymphoma
3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells.
Lymphoma
A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay.
Lymphoma
A mutational assay system using the thymidine kinase locus in mouse lymphoma cells.
Lymphoma
A non-radiometric method for measuring serum thymidine kinase activity in malignant lymphoma in dogs.
Lymphoma
A sensitive and kinetically defined radiochemical assay for canine and human serum thymidine kinase 1 (TK1) to monitor canine malignant lymphoma.
Lymphoma
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma.
Lymphoma
Absence of mutagenic effects of sodium dichloroacetate.
Lymphoma
Analyses of the genotoxic and mutagenic potential of the products formed after the biotransformation of the azo dye Disperse Red 1.
Lymphoma
Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay.
Lymphoma
Analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/- mouse lymphoma cells.
Lymphoma
Anti-Transgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Re-directed T Cells in Humans.
Lymphoma
Antiviral treatment of Epstein-Barr virus-associated lymphoproliferations.
Lymphoma
Ascorbate is detectably mutagenic in the L5178Y TK+/- cell mutation assay.
Lymphoma
Bromate induces loss of heterozygosity in the thymidine kinase gene of L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Lymphoma
Bromodeoxyuridine resistance induced in mouse lymphoma cells by microsomal activation of dimethylnitrosamine.
Lymphoma
Characterization of thymidine kinase in L5178Y mouse lymphoma cells.
Lymphoma
Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program.
Lymphoma
Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures.
Lymphoma
Chronic pyelonephritis presenting as multiple tumor-like renal lesions.
Lymphoma
Clinical performance of a commercially available thymidine kinase 1 assay for diagnosis of lymphoma in 42 hospitalized horses (2017-2020).
Lymphoma
Clinical significance of serum thymidine kinase in adult T-cell leukaemia and acute myeloid leukaemia.
Lymphoma
Comparison of chromosome aberration frequency and small-colony TK-deficient mutant frequency in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.
Lymphoma
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Lymphoma
Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity.
Lymphoma
Correlation between tumor proliferation and serum levels of beta 2-microglobulin and thymidine kinase in malignant lymphomas.
Lymphoma
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Lymphoma
Cytogenetic analysis of the L5178Y/TK+/- leads to TK-/- mouse lymphoma mutagenesis assay system.
Lymphoma
Cytogenetic evidence for hemizygosity at the thymidine kinase locus in P388 mouse lymphoma cells.
Lymphoma
Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y Tk+/--3.7.2C Mouse Lymphoma Cells.
Lymphoma
Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis.
Lymphoma
Do trifluorothymidine-resistant mutants of L5178Y mouse lymphoma cells re-express thymidine kinase activity following 5-azacytidine treatment?
Lymphoma
Dominance of resistance to the alkylating agent 1,2:5,6-dianhydrogalactitol in P388 mouse lymphoma hybrid cells.
Lymphoma
Dominant expression of multidrug resistance in intraspecific murine lymphoma hybrid cells.
Lymphoma
Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK+/- cells.
Lymphoma
Enzymes as prognostic markers and therapeutic indicators in patients with cancer.
Lymphoma
Evaluation of olestra in short-term genotoxicity assays.
Lymphoma
Evaluation of plasma levels of thymidine kinase and mutated p53 in 81 patients with newly diagnosed malignant lymphoma.
Lymphoma
Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: methods used and chemicals evaluated.
Lymphoma
Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test.
Lymphoma
Evidence for chemically-induced structural gene mutations at the thymidine kinase locus in cultured L5178Y mouse lymphoma cells.
Lymphoma
Final report on the safety assessment of octoxynol-1, octoxynol-3, octoxynol-5, octoxynol-6, octoxynol-7, octoxynol-8, octoxynol-9, octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-9 carboxylic acid, octoxynol-20 carboxylic acid, potassium octoxynol-12 phosphate, sodium octoxynol-2 ethane sulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, and sodium octoxynol-9 sulfate.
Lymphoma
Gene-mutation induction by arsenic compounds in the mouse lymphoma assay.
Lymphoma
Genetic toxicity studies of glycolipids from Dacryopinax spathularia.
Lymphoma
Genotoxicity and subchronic toxicity studies with heated olestra.
Lymphoma
Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E.
Lymphoma
Genotoxicity assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).
Lymphoma
Genotoxicity of gamma-irradiation in L5178Y mouse lymphoma cells.
Lymphoma
Hamster hepatocyte-mediated activation of procarcinogens to mutagens in the L5178Y/TK mutation assay.
Lymphoma
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia.
Lymphoma
Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Lymphoma
Identification of a heteromorphic microsatellite within the thymidine kinase gene in L5178Y mouse lymphoma cells.
Lymphoma
In vitro evaluation of the genotoxicity of poly(anhydride) nanoparticles designed for oral drug delivery.
Lymphoma
In vitro mammalian mutagenesis as a model for genetic lesions in human cancer.
Lymphoma
In vitro mouse lymphoma (L5178Y Tk?/?-3.7.2C) forward mutation assay.
Lymphoma
In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay.
Lymphoma
Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms.
Lymphoma
Issues for conducting the microtiter version of the mouse lymphoma thymidine kinase (tk) assay and a critical review of data generated in a collaborative trial using the microtiter method.
Lymphoma
Large mutagenic lesions are induced by photodynamic therapy in murine L5178Y lymphoblasts.
Lymphoma
Loss of P53 heterozygosity is not responsible for the small colony thymidine kinase mutant phenotype in L5178Y mouse lymphoma cells.
Lymphoma
Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene.
Lymphoma
Mammalian cell HPRT gene mutation assay: test methods.
Lymphoma
Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation.
Lymphoma
Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells.
Lymphoma
Modeling the mouse lymphoma forward mutational assay: the Gene-Tox program database.
Lymphoma
Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.
Lymphoma
Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity--evaluation of a new, fully automated non-radiometric assay.
Lymphoma
Mouse lymphoma L5178Y thymidine kinase locus assay of 50 compounds.
Lymphoma
Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000.
Lymphoma
Mouse lymphoma thymidine kinase gene mutation assay: Follow-up meeting of the international workshop on Genotoxicity testing-Aberdeen, Scotland, 2003-Assay acceptance criteria, positive controls, and data evaluation.
Lymphoma
Mouse lymphoma thymidine kinase gene mutation assay: International Workshop on Genotoxicity Tests Workgroup report--Plymouth, UK 2002.
Lymphoma
Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment.
Lymphoma
Mouse lymphoma thymidine kinase locus gene mutation assay: International Workshop on Genotoxicity Test Procedures Workgroup Report.
Lymphoma
Mutagenic activity of fluorides in mouse lymphoma cells.
Lymphoma
Mutagenic analysis of six disinfection by-products in the Tk gene of mouse lymphoma cells.
Lymphoma
Mutagenic screening of marker grenade dyes by the Salmonella reversion assay, L5178Y/TK+/- mouse lymphoma assay, and in vivo sister chromatid exchange analysis in mice.
Lymphoma
Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/(-)-3.7.2C mouse lymphoma cells.
Lymphoma
Mutagenicity and clastogenicity of proflavin in L5178Y/TK +/- -3.7.2.C cells.
Lymphoma
Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase.
Lymphoma
Mutagenicity of metal salts in the L5178Y mouse lymphoma assay.
Lymphoma
Mutagenicity of the mycotoxin alternariol in cultured mammalian cells.
Lymphoma
Mutagenicity studies of R-amino salt, a metabolite of amaranth (FD & C Red NO. 2), in mouse lymphoma cells heterozygous at the thymidine kinase locus and in the rat dominant lethal test.
Lymphoma
Mutagenicity tests of diflubenzuron in the micronucleus test in mice, the L5178Y mouse lymphoma forward mutation assay, and the Ames Salmonella reverse mutation test.
Lymphoma
Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.
Lymphoma
Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities.
Lymphoma
Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress.
Lymphoma
Photofrin II photosensitization is mutagenic at the tk locus in mouse L5178Y cells.
Lymphoma
Plasma thymidine kinase activity in dogs with lymphoma and leukemia.
Lymphoma
Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. I. Application to genetic toxicological testing.
Lymphoma
Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. II. Test validation and interpretation.
Lymphoma
Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.
Lymphoma
Primary non-Hodgkin's lymphoma of the gallbladder diagnosed by laparoscopic cholecystectomy.
Lymphoma
Procarbazine is a potent mutagen at the heterozygous thymidine kinase (tk +/-) locus of mouse lymphoma assay.
Lymphoma
Reactivity of catecholamines and related substances in the mouse lymphoma L5178Y cell assay for mutagens.
Lymphoma
Reversion in thymidine kinase deficient variants of mouse lymphoma P388.
Lymphoma
Risk classification for large cell lymphoma using lactate dehydrogenase, beta-2 microglobulin, and thymidine kinase.
Lymphoma
Safety and toxicological evaluation of a novel, water-soluble undenatured type II collagen.
Lymphoma
Safety assessment of a novel ingredient for removable chewing gum.
Lymphoma
Safety study of culinary-medicinal Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. KA21 (higher Basidiomycetes) assessed by prokaryotic as well as eukaryotic systems.
Lymphoma
Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas.
Lymphoma
Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma.
Lymphoma
Serum thymidine kinase activity in clinically healthy and diseased horses: A potential marker for lymphoma.
Lymphoma
Serum thymidine kinase activity in dogs with malignant lymphoma: a potent marker for prognosis and monitoring the disease.
Lymphoma
Serum thymidine kinase activity: an alternative to histologic markers of cellular proliferation in canine lymphoma.
Lymphoma
Serum thymidine kinase and soluble interleukin-2 receptor predict recurrence of malignant lymphoma.
Lymphoma
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Lymphoma
Serum thymidine kinase in non-Hodgkin lymphomas with special regard to multiple myeloma.
Lymphoma
Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents.
Lymphoma
Specific gene mutations in L5178Y cells in culture.
Lymphoma
Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.
Lymphoma
Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.
Lymphoma
Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells.
Lymphoma
The Current State of Clinical Application of Serum Biomarkers for Canine Lymphoma.
Lymphoma
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
Lymphoma
The L5178Y/tk+/- mouse lymphoma specific gene and chromosomal mutation assay a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program.
Lymphoma
The mouse lymphoma assay detects recombination, deletion, and aneuploidy.
Lymphoma
The mouse lymphoma assay.
Lymphoma
The mouse lymphoma thymidine kinase assay for the assessment and comparison of the mutagenic activity of cigarette mainstream smoke particulate phase.
Lymphoma
The mutagenic assay of some hair dye components, using the thymidine kinase locus of L5178Y mouse lymphoma cells.
Lymphoma
The mutagenic potency of 4 agents at the thymidine kinase locus in mouse lymphoma L5178Y cells in vitro: effects of exposure time.
Lymphoma
The mutagenicity of 5-azacytidine and other inhibitors of replicative DNA synthesis in the L5178Y mouse lymphoma cell.
Lymphoma
The spectral karyotype of L5178Y TK?/? mouse lymphoma cells clone 3.7.2C and factors affecting mutant frequency at the thymidine kinase (tk) locus in the microtitre mouse lymphoma assay.
Lymphoma
The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels.
Lymphoma
The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals.
Lymphoma
Thymidine kinase (TK) activity as a prognostic parameter of survival in lymphoma patients.
Lymphoma
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Lymphoma
Thymidine kinase assay in canine lymphoma.
Lymphoma
Thymidine kinase heterozygous L5178Y mouse lymphoma forward mutational assay.
Lymphoma
Thymidine kinase isoenzymes in human malignant lymphoma.
Lymphoma
Thymidine kinase levels correlate with prognosis in aggressive lymphoma and can discriminate patients with a clinical suspicion of indolent to aggressive transformation.
Lymphoma
Tissue enzyme changes in parabiotic rats with subcutaneous lymphoma or fibrosarcoma.
Lymphoma
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Lymphoma
Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations.
Lymphoma
Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.
Lymphoma
Whole genome sequencing analysis of small and large colony mutants from the mouse lymphoma assay.
Lymphoma
[A case report of lymphomatoid granulomatosis (LYG) with spontaneous attenuation]
Lymphoma
[Evaluation of the Acute Toxicity and Genotoxicity of the Rice Biofortified with ?-Glucan].
Lymphoma
[Serum thymidine kinase in the monitoring of lymphoma patients]
Lymphoma, B-Cell
Prognostic Value of High Thymidine Kinase Activity in Previously Untreated Diffuse Large B-Cell Lymphoma Patients Treated by R-CHOP.
Lymphoma, B-Cell
There is life in the old dog yet: thymidine kinase as predictive marker in diffuse large B-cell lymphoma.
Lymphoma, Follicular
Anti-Transgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Re-directed T Cells in Humans.
Lymphoma, Follicular
High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma.
Lymphoma, Large B-Cell, Diffuse
Anti-Transgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Re-directed T Cells in Humans.
Lymphoma, Large B-Cell, Diffuse
Deoxynucleoside overproduction in deoxyadenosine-resistant, adenosine deaminase-deficient human histiocytic lymphoma cells.
Lymphoma, Large B-Cell, Diffuse
Prognostic Value of High Thymidine Kinase Activity in Previously Untreated Diffuse Large B-Cell Lymphoma Patients Treated by R-CHOP.
Lymphoma, Large B-Cell, Diffuse
There is life in the old dog yet: thymidine kinase as predictive marker in diffuse large B-cell lymphoma.
Lymphoma, Non-Hodgkin
Activity of serum thymidine kinase in non-Hodgkin lymphoma: relationship to other prognostic factors.
Lymphoma, Non-Hodgkin
Calf Form Bovine Leukosis with Lameness in a Holstein Heifer.
Lymphoma, Non-Hodgkin
Circadian variations of interleukin-2 receptors, serum thymidine kinase and beta-2-microglobulin in patients with non-Hodgkin's lymphoma and normal controls.
Lymphoma, Non-Hodgkin
Clinical significance of circulating CD44 in non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Evaluation of serum thymidine kinase 1 activity as a biomarker for treatment effectiveness and prediction of relapse in dogs with non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Prognostic relevance of thymidine kinase isozymes in adult non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Pyrimidine and purine activities in non-Hodgkin's lymphoma. Correlation with histological status and survival.
Lymphoma, Non-Hodgkin
Retrospective study of the prognostic role of serum thymidine kinase level in CLL patients with active disease treated with fludarabine.
Lymphoma, Non-Hodgkin
Serum soluble CD27, but not thymidine kinase, is an independent prognostic factor for outcome in indolent non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Serum thymidine kinase 1 concentration as a prognostic factor of chemotherapy-treated non-Hodgkin's lymphoma patients.
Lymphoma, Non-Hodgkin
Thymidine kinase 1 is a potential marker for prognosis and monitoring the response to treatment of patients with breast, lung, and esophageal cancer and non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Lymphoma, Non-Hodgkin
Thymidine kinase: a tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications.
Lymphoproliferative Disorders
[Acyclovir in mycosis fungoides and lymphomatoid papulosis]
Malaria
High-performance liquid chromatographic assay for thymidylate synthase from the human malaria parasite, Plasmodium falciparum.
Malaria
Mild Plasmodium falciparum Malaria following an Episode of Severe Malaria Is Associated with Induction of the Interferon Pathway in Malawian Children.
Malaria
Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum.
Malaria, Cerebral
Mild Plasmodium falciparum Malaria following an Episode of Severe Malaria Is Associated with Induction of the Interferon Pathway in Malawian Children.
Malnutrition
DNA polymerase and thymidine kinase activities in different regions of rat brain during postnatal development: effect of undernutrition.
Malnutrition
Effects of hypothyroidism and undernutrition on DNA content and thymidine kinase activity during cerebellar development in the rat.
Marek Disease
Construction and properties of a turkey herpesvirus recombinant expressing the Marek's disease virus homologue of glycoprotein B of herpes simplex virus.
Marek Disease
Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the thymidine kinase and UL24 genes of herpes simplex virus type 1.
Marek Disease
Influence of chicken genotype on protection against Marek's disease by a herpesvirus of turkeys recombinant expressing the glycoprotein B (gB) of Marek's disease virus.
Marek Disease
Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses.
Mastocytoma
Effects of temperature changes on thymidine kinase in heat- and cold-sensitive cell-cycle mutants and 'wild-type' murine P-815 cells.
Mastocytoma
Selection of highly transfectable variant from mouse mastocytoma P815.
Measles
Construction of vaccinia virus recombinants expressing several measles virus proteins and analysis of their efficacy in vaccination of mice.
Medulloblastoma
Bystander effect in suicide gene therapy using immortalized neural stem cells transduced with herpes simplex virus thymidine kinase gene on medulloblastoma regression.
Medulloblastoma
In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma.
Melanoma
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
Melanoma
A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma.
Melanoma
A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma.
Melanoma
Antitumor effects on human melanoma xenografts of an amplicon vector transducing the herpes thymidine kinase gene followed by ganciclovir.
Melanoma
Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.
Melanoma
Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.
Melanoma
Curcumin plays a synergistic role in combination with HSV-TK/GCV in inhibiting growth of murine B16 melanoma cells and melanoma xenografts.
Melanoma
Diagnostic accuracy and predictive value of the tumor-associated antigen S100 in malignant melanomas: validation by whole body FDG-PET and conventional diagnostics.
Melanoma
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Melanoma
Differential metabolism of thymidine in human lymphoid and melanoma cells in vitro.
Melanoma
Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma.
Melanoma
Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-? and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line.
Melanoma
Efficient gene transfer into Xiphophorus muscle and melanoma by injection of supercoiled plasmid DNA.
Melanoma
Evaluation of combined gene regulatory elements for transcriptional targeting of suicide gene expression to malignant melanoma.
Melanoma
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Melanoma
Ex vivo delivery of suicide genes into melanoma cells using epidermal growth factor receptor-specific Fab immunogene.
Melanoma
Gene therapy for metastatic malignant melanoma: evaluation of tolerance to intratumoral injection of cells producing recombinant retroviruses carrying the herpes simplex virus type 1 thymidine kinase gene, to be followed by ganciclovir administration.
Melanoma
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Melanoma
Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma.
Melanoma
Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
Melanoma
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Melanoma
Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging.
Melanoma
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.
Melanoma
Protocol #0207-544: a phase study to evaluate the safety and pharmacokinetics of Pro-1, a liposome-encapsulated thymidine kinase gene formulation, in patients with stage IV metastatic melanoma.
Melanoma
S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase.
Melanoma
Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands.
Melanoma
Suppression of Cancer Growth by Nonviral Gene Therapy Based on a Novel Reactive Oxygen Species-responsive Promoter.
Melanoma
The efficacy of retroviral herpes simplex virus thymidine kinase gene transfer and ganciclovir treatment on the inhibition of melanoma growth in vitro and in vivo.
Melanoma
Thymidine kinase in malignant melanoma.
Melanoma
Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma.
Melanoma
Transformation of Bowes melanoma cells with SV40 T antigen.
Melanoma
Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses.
Melanoma
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Melanoma
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
Melanoma
[Gene therapy using recombinant adenovirus carrying herpes simplex-thymidine kinase gene to treat mouse B 16 melanoma in vivo]
Melanoma
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
Melanoma, Experimental
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Melanoma, Experimental
Thymidine kinase in malignant melanoma.
Meningeal Carcinomatosis
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Meningeal Carcinomatosis
Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study.
Meningeal Carcinomatosis
Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells.
Meningioma
Progesterone and glucocorticoid receptor activation in meningiomas.
Meningoencephalitis
Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.
MERRF Syndrome
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
MERRF Syndrome
Generation of two isogenic human induced pluripotent stem cell lines from a 15?year-old female patient with MERRF syndrome and A8344G mutation of mitochondrial DNA.
MERRF Syndrome
MERRF Classification: Implications for Diagnosis and Clinical Trials.
MERRF Syndrome
Photosensitive Epilepsy and Polycystic Ovary Syndrome as Manifestations of MERRF.
MERRF Syndrome
Recovery of MERRF Fibroblasts and Cybrids Pathophysiology by Coenzyme Q(10).
MERRF Syndrome
[Development of a DNA biochip for detection of known mtDNA mutations associated with MELAS and MERRF syndromes.]
Mesothelioma
A pilot study of systemic corticosteroid administration in conjunction with intrapleural adenoviral vector administration in patients with malignant pleural mesothelioma.
Mesothelioma
Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.
Mesothelioma
Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics.
Mesothelioma
Enzyme pathology of human mesotheliomas.
Mesothelioma
Gene therapy for malignant mesothelioma: beyond the infant years.
Mesothelioma
Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.
Mesothelioma
Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene.
Mesothelioma
Treatment of mesothelioma with gene-modified PA1STK cells and ganciclovir: a phase I study.
Mesothelioma
Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene.
Mesothelioma, Malignant
Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene.
Mesothelioma, Malignant
Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy.
Mesothelioma, Malignant
Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene.
Metrorrhagia
Direct assay of thymidine kinase bound to ion-exchange paper for dot spotting and enzyme blotting analysis.
Mitochondrial Diseases
An A8296G mutation in the MT-TK gene of a patient with epilepsy - a disease-causing mutation or rare polymorphism?
Mitochondrial Encephalomyopathies
Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies.
Mitochondrial Myopathies
A defect in the thymidine kinase 2 gene causing isolated mitochondrial myopathy without mtDNA depletion.
Mitochondrial Myopathies
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Mitochondrial Myopathies
Novel mutations in the thymidine kinase 2 gene (TK2) associated with fatal mitochondrial myopathy and mitochondrial DNA depletion.
Mitochondrial Myopathies
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
Monkeypox
Nucleotide sequence of the thymidine kinase gene region of monkeypox and variola viruses.
Monkeypox
Orthopoxvirus DNA in eurasian lynx, sweden.
Monkeypox
Quaternary structure of vaccinia virus thymidine kinase.
Monoclonal Gammopathy of Undetermined Significance
Analysis of thymidine kinase serum levels by novel method DiviTum in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT.
Monoclonal Gammopathy of Undetermined Significance
Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
Monoclonal Gammopathy of Undetermined Significance
Serum thymidine kinase in monoclonal gammopathies. A prospective study. The Cooperative Group for Study and Treatment of Multiple Myeloma.
Monoclonal Gammopathy of Undetermined Significance
[Analysis of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma]
Mouth Neoplasms
Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer.
Mouth Neoplasms
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Mouth Neoplasms
Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: application to HSV-tk/ganciclovir-mediated cytotoxicity.
Multiple Myeloma
Adenovirus vector-based purging of multiple myeloma cells.
Multiple Myeloma
Analysis of thymidine kinase serum levels by novel method DiviTum in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT.
Multiple Myeloma
Chronobiological circadian aspects of serum lactate dehydrogenase and serum thymidine kinase in monitoring multiple myeloma.
Multiple Myeloma
Plasma cell labeling index and beta 2-microglobulin predict survival independent of thymidine kinase and C-reactive protein in multiple myeloma.
Multiple Myeloma
Prognostic factors in multiple myeloma.
Multiple Myeloma
Prognostic factors in multiple myeloma: role of beta 2-microglobulin and thymidine kinase.
Multiple Myeloma
Prognostic value of serum thymidine kinase and beta 2 microglobulin in subjects affected by multiple myeloma.
Multiple Myeloma
Retrospective study of the prognostic role of serum thymidine kinase level in CLL patients with active disease treated with fludarabine.
Multiple Myeloma
Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
Multiple Myeloma
Serum thymidine kinase as a marker of disease activity in patients with multiple myeloma.
Multiple Myeloma
Serum thymidine kinase as a prognostic indicator for patients with multiple myeloma: results from the MRC (UK) V trial.
Multiple Myeloma
Serum thymidine kinase in monoclonal gammopathies. A prospective study. The Cooperative Group for Study and Treatment of Multiple Myeloma.
Multiple Myeloma
Serum thymidine kinase in non-Hodgkin lymphomas with special regard to multiple myeloma.
Multiple Myeloma
[Analysis of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma]
Multiple Myeloma
[Biochemical markers of multiple myeloma]
Multiple Myeloma
[Serum thymidine kinase in multiple myeloma: I. Relation to selected laboratory indicators in the disease]
Multiple Myeloma
[Serum thymidine kinase in multiple myeloma: II. Relation to disease activity and stage]
Muscular Atrophy, Spinal
New Mutations in TK2 Gene Associated With Mitochondrial DNA Depletion.
Muscular Diseases
Advances in primary mitochondrial myopathies.
Muscular Diseases
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Muscular Diseases
Deoxynucleoside Therapy for Thymidine Kinase 2-Deficient Myopathy.
Muscular Diseases
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
Muscular Diseases
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy.
Muscular Diseases
Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency.
Muscular Diseases
Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA.
Muscular Diseases
mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency.
Muscular Diseases
Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.
Muscular Diseases
New Mutations in TK2 Gene Associated With Mitochondrial DNA Depletion.
Muscular Diseases
Onset and organ-specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation.
Muscular Diseases
Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion.
Myelodysplastic Syndromes
Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia.
Myelodysplastic Syndromes
[The prognostic significance of serum thymidine kinase in the myelodysplastic syndrome]
Myocardial Infarction
Mechanism of Improved Cardiac Function After Bone Marrow Mononuclear Cell Therapy. Role of Cardiovascular Lineage Commitment.
Myocardial Infarction
Multimodality molecular imaging to monitor transplanted stem cells for the treatment of ischemic heart disease.
Myotonia
Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle.
Myxoma
The myxoma virus thymidine kinase gene: sequence and transcriptional mapping.
Nasopharyngeal Carcinoma
A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: implications for radiosensitization and EBV-targeted therapy.
Nasopharyngeal Carcinoma
A novel fusion suicide gene yeast CDglyTK plays a role in radio-gene therapy of nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Antibodies to Epstein-Barr virus thymidine kinase: a characteristic marker for the serological detection of nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Diagnosis of nasopharyngeal carcinoma by means of recombinant Epstein-Barr virus proteins.
Nasopharyngeal Carcinoma
Immune responses to Epstein-Barr virus lytic proteins in patients with nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Immunological response of nasopharyngeal carcinoma patients to the Epstein-Barr-virus-coded thymidine kinase expressed in Escherichia coli.
Nasopharyngeal Carcinoma
Induction of chemosensitivity in nasopharyngeal carcinoma cells using a human papillomavirus regulatory sequence and the thymidine kinase gene.
Nasopharyngeal Carcinoma
Relationship between nasopharyngeal carcinoma and high antibody titers to Epstein-Barr virus-specific thymidine kinase.
Nasopharyngeal Carcinoma
Use of antigen expressed in bacteria for detection of EBV-specific thymidine kinase antibodies in sera from patients with nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
[Enhanced thymidine kinase gene vector and its killing effect on nasopharyngeal carcinoma in vitro and in vivo].
Nasopharyngeal Neoplasms
Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.
Nasopharyngeal Neoplasms
Long-circulating liposome-encapsulated ganciclovir enhances the efficacy of HSV-TK suicide gene therapy.
Nasopharyngeal Neoplasms
Targeted gene therapy of nasopharyngeal cancer in vitro and in vivo by enhanced thymidine kinase expression driven by human TERT promoter and CMV enhancer.
Neoplasm Metastasis
5-azacytidine induction of thymidine kinase in a spontaneously enzyme-deficient murine tumor line.
Neoplasm Metastasis
Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors.
Neoplasm Metastasis
Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer.
Neoplasm Metastasis
An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice.
Neoplasm Metastasis
Bone metastasis imaging with SPECT/CT/MRI: A preclinical toolbox for therapy studies.
Neoplasm Metastasis
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Neoplasm Metastasis
Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer.
Neoplasm Metastasis
Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir.
Neoplasm Metastasis
Human colorectal malignancy and oral UFT.
Neoplasm Metastasis
Human Embryonic Stem Cell-Derived Endothelial Cells as Cellular Delivery Vehicles for Treatment of Metastatic Breast Cancer.
Neoplasm Metastasis
In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery.
Neoplasm Metastasis
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Neoplasm Metastasis
Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging.
Neoplasm Metastasis
Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model.
Neoplasm Metastasis
Papers to appear in forthcoming issues
Neoplasm Metastasis
Preoperative tumor markers as prognostic factors of colorectal liver metastases.
Neoplasm Metastasis
Prognostic Factors After Surgical Treatment of Liver Metastases from Breast Cancer - 19 Years of Experience.
Neoplasm Metastasis
Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.
Neoplasm Metastasis
Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases.
Neoplasm Metastasis
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Neoplasm Metastasis
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver.
Neoplasm Metastasis
Serum thymidine kinase in colorectal neoplasia.
Neoplasm Metastasis
Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration.
Neoplasm Metastasis
Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Neoplasm Metastasis
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis.
Neoplasm Metastasis
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Neoplasm Metastasis
The clinical course and management of cervical cancer with splenic metastasis: Case report and review of the literature.
Neoplasm Metastasis
The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.
Neoplasm Metastasis
Total vascular exclusion of the liver enhances the efficacy of retroviral-mediated associated thymidine kinase and interleukin-2 genes transfer against multiple hepatic tumors in rats.
Neoplasm Metastasis
Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy.
Neoplasm Metastasis
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization.
Neoplasm Metastasis
[Prognostic value of thymidine kinase in cancer of the breast]
Neoplasm Metastasis
[Study of DNA microarray chip of associated genes of hydatidiform mole]
Neoplasm Micrometastasis
Combination of pet imaging with viral vectors for identification of cancer metastases.
Neoplasm, Residual
[Research Progress on Prognostic Factors of Multiple Myeloma--Review].
Neoplasms
"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest.
Neoplasms
"Suicide" gene therapy of breast cancer cells is only cytostatic in vitro but anti-tumoral in vivo on breast MCF7-ras tumor.
Neoplasms
(111)In-DOTA-Annexin V for imaging of apoptosis during HSV1-tk/GCV prodrug activation gene therapy in mice with NG4TL4 sarcoma.
Neoplasms
(18)F-FLT PET imaging of cellular proliferation in pancreatic cancer.
Neoplasms
(3)H-Penciclovir ((3)H-PCV) Uptake Assay.
Neoplasms
(99m)Tc-EC-guanine: synthesis, biodistribution, and tumor imaging in animals.
Neoplasms
(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
Neoplasms
1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene in rats.
Neoplasms
17-Allylamino-17-demethoxygeldanamycin-induced Changes in [(18)F]Fluorothymidine Uptake.
Neoplasms
3'-deoxy-3'-[(18) F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: A pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response.
Neoplasms
3'-Deoxy-3'-[18F]fluorothymidine positron emission tomography imaging of thymidine kinase 1 activity after 5-fluorouracil treatment in a mouse tumor model.
Neoplasms
5-azacytidine induction of thymidine kinase in a spontaneously enzyme-deficient murine tumor line.
Neoplasms
5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
Neoplasms
5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase.
Neoplasms
5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression.
Neoplasms
8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET.
Neoplasms
A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect.
Neoplasms
A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease.
Neoplasms
A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy.
Neoplasms
A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer.
Neoplasms
A guanylate kinase/HSV-1 thymidine kinase fusion protein enhances prodrug-mediated cell killing.
Neoplasms
A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.
Neoplasms
A meta-analysis of serological thymidine kinase 1 as a marker for colorectal benign and malignant tumor risk assessment.
Neoplasms
A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir.
Neoplasms
A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography.
Neoplasms
A monoclonal antibody specific for human thymidine kinase 1.
Neoplasms
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.
Neoplasms
A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.
Neoplasms
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma.
Neoplasms
A new oncolytic Vacciniavirus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery.
Neoplasms
A New Sandwich ELISA for Quantification of Thymidine Kinase 1 Protein Levels in Sera from Dogs with Different Malignancies Can Aid in Disease Management.
Neoplasms
A nomogram to predict individual prognosis in node-negative breast carcinoma.
Neoplasms
A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.
Neoplasms
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group.
Neoplasms
A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies.
Neoplasms
A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients.
Neoplasms
A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma.
Neoplasms
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma.
Neoplasms
A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging.
Neoplasms
A role for MAP kinase in the antitumor activity of a nucleoside analog.
Neoplasms
A simple quantitative assay for the activity of thymidine kinase 1 in solid tumors.
Neoplasms
A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.
Neoplasms
A site of action for zinc in neoplastic tissue.
Neoplasms
A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells.
Neoplasms
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma.
Neoplasms
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
Neoplasms
Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissues.
Neoplasms
Activity of the cytosolic isozyme of thymidine kinase in human primary lung tumors with reference to malignancy.
Neoplasms
Activity of thymidilate "salvage pathway" enzymes in human gastric cancer and blood serum: correlation with treatment modalities.
Neoplasms
Additional effects of medroxyprogesterone acetate on mammary tumors in oophorectomized, estrogenized, DMBA-treated rats.
Neoplasms
Additive effects of medroxyprogesterone acetate and 5-fluorouracil derivative on 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.
Neoplasms
Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model.
Neoplasms
Adenoviral insulinoma-associated protein 1 promoter-driven suicide gene therapy with enhanced selectivity for treatment of neuroendocrine cancers.
Neoplasms
Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity.
Neoplasms
Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer.
Neoplasms
Adenoviral-delivered HE4-HSV-tk sensitizes ovarian cancer cells to ganciclovir.
Neoplasms
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Neoplasms
Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors.
Neoplasms
Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies.
Neoplasms
Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.
Neoplasms
Adenovirus E1a protein enhances the cytotoxic effects of the herpes thymidine kinase-ganciclovir system.
Neoplasms
Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration.
Neoplasms
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Neoplasms
Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.
Neoplasms
Adenovirus-mediated gene therapy of experimental gliomas.
Neoplasms
Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression.
Neoplasms
Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing.
Neoplasms
Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.
Neoplasms
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
Neoplasms
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Neoplasms
Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.
Neoplasms
Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma.
Neoplasms
Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases.
Neoplasms
Allium sativum potentiates suicide gene therapy for murine transitional cell carcinoma.
Neoplasms
alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil.
Neoplasms
Amino acid metabolizing enzymes in rat submaxillary gland, normal or neoplastic, and in pancreas.
Neoplasms
An adenovirus vector containing the suicide gene thymidine kinase for a broad application in cancer gene therapy.
Neoplasms
An autologous in situ tumor vaccination approach for hepatocellular carcinoma. 1. Flt3 ligand gene transfer increases antitumor effects of a radio-inducible suicide gene therapy in an ectopic tumor model.
Neoplasms
An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.
Neoplasms
Anti-tumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras(G12V).
Neoplasms
Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models.
Neoplasms
Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways.
Neoplasms
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Neoplasms
Application of an in vitro assay for serum thymidine kinase: results on viral disease and malignancies in humans.
Neoplasms
Applying the herpes simplex virus thymidine kinase/ganciclovir approach to ovarian cancer: an effective in vitro drug-sensitization system.
Neoplasms
Approaches to utilize mesenchymal progenitor cells as cellular vehicles.
Neoplasms
Aptamer-Based Sandwich Assay for Measurement of Thymidine Kinase 1 in Serum of Cancerous Patients.
Neoplasms
Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene.
Neoplasms
AroCell TK 210 ELISA for determination of TK1 protein: age-related reference ranges and comparison with other TK1 assays.
Neoplasms
Assays for noninvasive imaging of reporter gene expression.
Neoplasms
Assessment of ?-Fetoprotein Targeted HSV1-tk Expression in Hepatocellular Carcinoma with In Vivo Imaging.
Neoplasms
Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.
Neoplasms
Assessment of drug-induced dysregulations among seven resistance-associated genes in human tumour cell lines.
Neoplasms
Assignment of the integration site for simian virus 40 to chromosome 17 in GM54VA, a human cell line transformed by simian virus 40.
Neoplasms
Assignment of Tp53 and Tk1 to chromosome 13 in Peromyscus by fluorescence in situ hybridization.
Neoplasms
AV.TK-mediated killing of subcutaneous tumors in situ results in effective immunization against established secondary intracranial tumor deposits.
Neoplasms
Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy.
Neoplasms
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
Neoplasms
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Neoplasms
Basic peptide system for efficient delivery of foreign genes.
Neoplasms
Basis of FLT as a cell proliferation marker: comparative uptake studies with [3H]thymidine and [3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines.
Neoplasms
Biochemical changes in premalignant intestines.
Neoplasms
Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.
Neoplasms
Biochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma.
Neoplasms
Biochemical modulation of 5-fluorouracil with interferon alpha/beta and gamma on murine renal cell carcinoma.
Neoplasms
Biochemical modulation of 5-fluorouracil with murine interferon-alpha/beta against murine renal cell carcinoma.
Neoplasms
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination.
Neoplasms
Biochemical tissue markers of human colorectal carcinoma.
Neoplasms
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Neoplasms
Bioluminescence imaging of a tumor-selective, thymidine kinase-defective vaccinia virus Guang9 strain after intratumoral or intraperitoneal administration in mice.
Neoplasms
Biomedical applications of nanoflares: Targeted intracellular fluorescence probes.
Neoplasms
Biomimetic cell membrane-coated DNA nanoparticles for gene delivery to glioblastoma.
Neoplasms
Bone metastasis imaging with SPECT/CT/MRI: A preclinical toolbox for therapy studies.
Neoplasms
Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors.
Neoplasms
Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues.
Neoplasms
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.
Neoplasms
Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.
Neoplasms
c-erbB-2/c-erbA co-amplification indicative of lymph node metastasis, and c-myc amplification of high tumour grade, in human breast carcinoma.
Neoplasms
cAMP stimulates the bystander effect in suicide gene therapy of human choriocarcinoma.
Neoplasms
Can thymidine kinase levels in breast tumors predict disease recurrence?
Neoplasms
Cancer Cell Targeting with Mouse TERT-Specific Group I Intron of Tetrahymena thermophila.
Neoplasms
Cancer gene therapy by direct tumor injections of a nonviral T7 vector encoding a thymidine kinase gene.
Neoplasms
Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo.
Neoplasms
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.
Neoplasms
Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models.
Neoplasms
Cationic liposomes enhance retrovirus-mediated multinucleated cell formation and retroviral transduction.
Neoplasms
Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells.
Neoplasms
Cell cycle related studies on thymidine kinase and its isoenzymes in Ehrlich ascites tumours.
Neoplasms
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Neoplasms
Cell-specific targeting of a thymidine kinase/ganciclovir gene therapy system using a recombinant Sindbis virus vector.
Neoplasms
Cell-specific viral gene therapy of a Hurthle cell tumor.
Neoplasms
Cells producing recombinant retrovirus with thymidine kinase gene from Herpes simplex virus suitable for human cancer gene therapy.
Neoplasms
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Neoplasms
Changes in serum thymidine kinase 1 levels during chemotherapy correlate with objective response in patients with advanced gastric cancer.
Neoplasms
Changes of serum thymidine kinase in children with acute leukemia.
Neoplasms
Changes of thymidine kinase (TK) during adjuvant and palliative chemotherapy.
Neoplasms
Changes of tumor vascularity during gene therapy monitored with color Doppler US.
Neoplasms
Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.
Neoplasms
Characterization of HIV-1 TAT peptide as an enhancer of HSV-TK/GCV cancer gene therapy.
Neoplasms
Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1.
Neoplasms
Characterization of the purified cytosolic thymidine kinase from murine ehrlich ascites tumor: interconversion of two different relative molecular weight forms.
Neoplasms
Characterization of three essential residues in the conserved ATP-binding region of Epstein-Barr virus thymidine kinase.
Neoplasms
Charge dependent substrate activity of C3' and N3 functionalized, organometallic technetium and rhenium-labeled thymidine derivatives toward human thymidine kinase 1.
Neoplasms
Chemoprevention of cancer by organoselenium compounds.
Neoplasms
Chronic lymphocytic leukemia: novel prognostic factors and their relevance for risk-adapted therapeutic strategies.
Neoplasms
Circadian variations of interleukin-2 receptors, serum thymidine kinase and beta-2-microglobulin in patients with non-Hodgkin's lymphoma and normal controls.
Neoplasms
Circulating Biomarkers of CDK4/6 Inhibitors Response in Hormone Receptor Positive and HER2 Negative Breast Cancer.
Neoplasms
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Neoplasms
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Neoplasms
Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.
Neoplasms
Clinical relevance of thymidine kinase for the diagnosis, therapy monitoring and prognosis of non-operable lung cancer.
Neoplasms
Clinical significance of circulating CD44 in non-Hodgkin's lymphoma.
Neoplasms
Clinical significance of thymidine kinase in Egyptian children with acute lymphoblastic leukemia.
Neoplasms
Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth.
Neoplasms
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM.
Neoplasms
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Neoplasms
Combination effect of oncolytic adenovirus therapy and herpes simplex virus thymidine kinase/ganciclovir in hepatic carcinoma animal models.
Neoplasms
Combination electro-gene therapy using herpes virus thymidine kinase and interleukin-12 expression plasmids is highly efficient against murine carcinomas in vivo.
Neoplasms
Combination gene therapy for liver metastasis of colon carcinoma in vivo.
Neoplasms
Combination gene therapy for salivary gland cancer.
Neoplasms
Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase.
Neoplasms
Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma.
Neoplasms
Combination of pet imaging with viral vectors for identification of cancer metastases.
Neoplasms
Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival.
Neoplasms
Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide gene.
Neoplasms
Combined radionuclide-chemotherapy and in vivo imaging of hepatocellular carcinoma cells after transfection of a triple-gene construct, NIS, HSV1-sr39tk, and EGFP.
Neoplasms
Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors.
Neoplasms
Combining Small Interfering RNAs Targeting Thymidylate Synthase and Thymidine Kinase 1 or 2 Sensitizes Human Tumor Cells to 5-Fluorodeoxyuridine and Pemetrexed.
Neoplasms
Comparative aspects of the proliferation marker thymidine kinase 1 in human and canine tumour diseases.
Neoplasms
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Neoplasms
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Neoplasms
Comparison of different methods to assess the cytotoxic effects of cytosine deaminase and thymidine kinase gene therapy.
Neoplasms
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Neoplasms
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Neoplasms
Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue.
Neoplasms
Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene.
Neoplasms
Complete regression of metastatic de-differentiated liposarcoma with engineered mesenchymal stromal cells with dTRAIL and HSV-TK.
Neoplasms
Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity.
Neoplasms
Concerted stimulation of transcription by glucocorticoid receptors and basal transcription factors: limited transcriptional synergism suggests mediation by coactivators/adaptors.
Neoplasms
Configurations of a two-tiered amplified gene expression system in adenoviral vectors designed to improve the specificity of in vivo prostate cancer imaging.
Neoplasms
Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV.
Neoplasms
Connexin 43-enhanced suicide gene therapy using herpesviral vectors.
Neoplasms
Connexin 43-mediated bystander effect in two rat glioma cell models.
Neoplasms
Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing colon cell line.
Neoplasms
Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities.
Neoplasms
Constitutive overexpression of DNA binding activity to the distal CCAAT box of human thymidine kinase promoter in human tumor cell lines.
Neoplasms
Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.
Neoplasms
Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen.
Neoplasms
Contribution of a combination of ponicidin and acyclovir/ganciclovir to the antitumor efficacy of the herpes simplex virus thymidine kinase gene therapy system.
Neoplasms
Control of Ehrlich cell division by zinc.
Neoplasms
Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.
Neoplasms
Correction to: Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies.
Neoplasms
Correlation between tumor proliferation and serum levels of beta 2-microglobulin and thymidine kinase in malignant lymphomas.
Neoplasms
Correlation of 18F-FLT uptake with equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in gastrointestinal cancer.
Neoplasms
Correlation of glucocorticoid receptor binding sites on MMTV proviral DNA with hormone inducible transcription.
Neoplasms
Correlations of (18)F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase 1 expressions in primary and metastatic lymph node colorectal cancer foci.
Neoplasms
Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells.
Neoplasms
Cowpox Virus: A New and Armed Oncolytic Poxvirus.
Neoplasms
Cre/loxP system controlled by specific promoter for radiation-mediated gene therapy of hepatoma.
Neoplasms
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.
Neoplasms
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Neoplasms
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Neoplasms
Cure of mice with established metastatic friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-alpha 1 and herpes simplex thymidine kinase followed by ganciclovir.
Neoplasms
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy.
Neoplasms
Cytosolic thymidine kinase is a specific histopathologic tumour marker for breast carcinomas.
Neoplasms
Cytotoxicity and antiangiogenesis by fibroblast growth factor 2-targeted Ad-TK cancer gene therapy.
Neoplasms
Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.
Neoplasms
Deletion of Apoptosis Inhibitor F1L in Vaccinia Virus Increases Safety and Oncolysis for Cancer Therapy.
Neoplasms
Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics.
Neoplasms
Deoxycytidine and deoxythymidine kinase activities in plasma of mice and patients with neoplastic disease.
Neoplasms
Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using 18F-ICMT-11 and 18F-FLT PET.
Neoplasms
Derivation of a triple mosaic adenovirus for cancer gene therapy.
Neoplasms
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
Neoplasms
Development of (18)F-labeled PET probes for imaging cell proliferation.
Neoplasms
Development of anti-tumor immunity against a non-immunogenic mammary carcinoma through in vivo somatic GM-CSF, IL-2, and HSVtk combination gene therapy.
Neoplasms
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.
Neoplasms
Development of Systemic Immunologic Responses Against Hepatic Metastases During Gene Therapy for Peritoneal Carcinomatosis With Retroviral HS-tk and Ganciclovir.
Neoplasms
Diagnostic and Prognostic Value of Serum Thymidine Kinase 1 in Cancer Patients.
Neoplasms
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Neoplasms
Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells.
Neoplasms
Different regulation of the human thymidine kinase promoter in normal human diploid IMR-90 fibroblasts and HeLa cells.
Neoplasms
Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells.
Neoplasms
Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer.
Neoplasms
Differential expression of thymidine kinase gene in two subpopulations of a rat tumour correlates with their tumorigenic and cell division potential.
Neoplasms
Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase.
Neoplasms
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Neoplasms
Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy.
Neoplasms
Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase.
Neoplasms
Direct intratumoral gene transfer of the herpes simplex virus thymidine kinase gene with DNA-liposome complexes: growth inhibition of tumors and lack of localization in normal tissues.
Neoplasms
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
Neoplasms
DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.
Neoplasms
DNA synthesis in tumor-bearing rats.
Neoplasms
DNA-liposome complexes transduction of herpes simplex virus thymidine kinase renders human tongue cancer cell line sensitive to ganciclovir in vitro.
Neoplasms
Do there exist synergistic antitumor effects by coexpression of herpes simplex virus thymidine kinase with cytokine genes on human gastric cancer cell line SGC7901?
Neoplasms
Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging.
Neoplasms
E1A RNA transcripts amplify adenovirus-mediated tumor reduction.
Neoplasms
Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume.
Neoplasms
Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro.
Neoplasms
Effect of adenosine3', 5'-monophosphate on thymidine kinase in tumor cells.
Neoplasms
Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect".
Neoplasms
Effect of hyperthermia on thymidine salvage as related to DNA synthesis.
Neoplasms
Effect of methylation on expression of microinjected genes.
Neoplasms
Effect of NK cell immunotherapy on immune function in patients with hepatic carcinoma: A preliminary clinical study.
Neoplasms
Effect of p53 activation on cell growth, thymidine kinase-1 activity, and 3'-deoxy-3'fluorothymidine uptake.
Neoplasms
Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis.
Neoplasms
Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma.
Neoplasms
Effect of thymidine and thymidylate analogs on nucleic acid synthesis in tumor cells.
Neoplasms
Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase.
Neoplasms
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.
Neoplasms
Effects of beta-carotene-rich algae Dunaliella bardawil on the dynamic changes of normal and neoplastic mammary cells and general metabolism in mice.
Neoplasms
Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.
Neoplasms
Effects of danazol on proliferation and viability of 7,12-dimethylbenz(a)anthracene-induced mammary tumours in rats.
Neoplasms
Effects of estrogen and prolactin on thymidine kinase isozyme activities in DMBA-induced rat mammary tumor.
Neoplasms
Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Neoplasms
Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.
Neoplasms
Effects of tamoxifen on mammary tumors and bone in 7,12-dimethylbenz-(a)anthracene-treated rats.
Neoplasms
Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-? and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line.
Neoplasms
Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model.
Neoplasms
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Neoplasms
Efficacy of lentivirus-mediated and MUC1 antibody-targeted VP22-TK/GCV suicide gene therapy for ovarian cancer.
Neoplasms
Efficacy of repeated adenoviral suicide gene therapy in a localized murine tumor model.
Neoplasms
Efficient suicide gene therapy of transduced and distant untransduced ovary tumors is correlated with significant increase of intratumoral T and NK cells.
Neoplasms
Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model.
Neoplasms
Elevated serum and mononuclear leukocyte thymidine kinase activities in patients with cancer.
Neoplasms
Elevated serum thymidine kinase 1 predicts risk of pre/early cancerous progression.
Neoplasms
Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response.
Neoplasms
Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons.
Neoplasms
Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase.
Neoplasms
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase.
Neoplasms
Enhanced efficiency and specificity of ovarian cancer gene therapy in rats with a novel nonviral gene delivery system (GE7) via intraovarian artery perfusion approach.
Neoplasms
Enhanced expression of thymidine kinase in human cells following ionizing radiation.
Neoplasms
Enhanced ganciclovir killing and bystander effect of human tumor cells transduced with a retroviral vector carrying a herpes simplex virus thymidine kinase gene mutant.
Neoplasms
Enhanced HIV-1 envelope-tumor protection by a recombinant vaccinia virus expressing anchored HIV-1 gp120 lacking gp41.
Neoplasms
Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene.
Neoplasms
Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase.
Neoplasms
Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator.
Neoplasms
Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.
Neoplasms
Enhancement of tumor killing using a combination of tumor immunization and HSV-tk suicide gene therapy.
Neoplasms
Enhancing effect of tumor promoters, phorbol esters and teleocidins on nuclear receptor-mediated transcription.
Neoplasms
Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy.
Neoplasms
Enzyme kinetics of thymidine kinase isoenzymes of Ehrlich ascites tumour.
Neoplasms
Enzyme pathology and the histologic categorization of human lung tumors: the continuum of quantitative biochemical indices of neoplasticity.
Neoplasms
EORTC receptor and biomarker study group report analytical and technical evaluation of a thymidine kinase radio-enzymatic assay in breast cancer cytosols.
Neoplasms
Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target.
Neoplasms
Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma.
Neoplasms
ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers.
Neoplasms
Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging.
Neoplasms
Establishment of parameters for optimal transduction efficiency and antitumor effects with purified high-titer HSV-TK retroviral vector in established solid tumors.
Neoplasms
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.
Neoplasms
Evaluation of an E1E4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy.
Neoplasms
Evaluation of Arginine Deiminase Treatment in Melanoma Xenografts Using (18)F-FLT PET.
Neoplasms
Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis.
Neoplasms
Evaluation of herpes simplex virus 1 thymidine kinase-mediated trapping of (131)I FIAU and prodrug activation of ganciclovir as a synergistic cancer radio/chemotherapy.
Neoplasms
Evaluation of human thymidine kinase 1 substrates as new candidates for boron neutron capture therapy.
Neoplasms
Evaluation of prodrugs ability to induce effective ablation of cells transduced with viral thymidine kinase gene.
Neoplasms
Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against Herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells.
Neoplasms
Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study.
Neoplasms
Evaluation of Tumor Specificity and Immunity of Thymidine Kinase-Deleted Vaccinia Virus Guang9 Strain.
Neoplasms
Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer.
Neoplasms
Evaluation of [(18)F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer.
Neoplasms
Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53.
Neoplasms
Experimental therapy of allogeneic solid tumors induced in athymic mice with suicide gene-transducing replication-competent foamy virus vectors.
Neoplasms
Exposed proliferation antigen 210 (XPA-210) in renal cell carcinoma (RCC) and oncocytoma: clinical utility and biological implications.
Neoplasms
Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene.
Neoplasms
Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.
Neoplasms
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
Neoplasms
Expression of thymidine kinase driven by an endothelial-specific promoter inhibits tumor growth of Lewis lung carcinoma cells in transgenic mice.
Neoplasms
FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Neoplasms
Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice.
Neoplasms
FLT-PET may not be a reliable indicator of therapeutic response in p53-null malignancy.
Neoplasms
Foamy virus vectors for suicide gene therapy.
Neoplasms
Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model.
Neoplasms
Foetal thymidine kinase in tumours and colonic flat mucosa of man.
Neoplasms
Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer.
Neoplasms
Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo.
Neoplasms
Fusion of the Human Immunodeficiency Virus Type 1 Tat Protein Transduction Domain to Thymidine Kinase Increases Bystander Effect and Induces Enhanced Tumor Killing In Vivo.
Neoplasms
Fusion of the human immunodeficiency virus type 1 tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo.
Neoplasms
Gamma-rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/ganciclovir on cancer cells.
Neoplasms
Ganciclovir chemoablation of herpes thymidine kinase suicide gene-modified tumors produces tumor necrosis and induces systemic immune responses.
Neoplasms
Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis.
Neoplasms
Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene.
Neoplasms
Gap junctions in human glioblastomas: implications for suicide gene therapy.
Neoplasms
Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.
Neoplasms
Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo.
Neoplasms
Gene dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas.
Neoplasms
Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer.
Neoplasms
Gene Targeting to Hepatomas (AFP).
Neoplasms
Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.
Neoplasms
Gene therapy for brain tumors.
Neoplasms
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.
Neoplasms
Gene therapy for colon cancer with the herpes simplex thymidine kinase gene.
Neoplasms
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Neoplasms
Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir.
Neoplasms
Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.
Neoplasms
Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector.
Neoplasms
Gene therapy for lung cancer.
Neoplasms
Gene therapy for malignant mesothelioma: a novel approach for an incurable cancer with increased incidence in Louisiana.
Neoplasms
Gene therapy for malignant mesothelioma: beyond the infant years.
Neoplasms
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir.
Neoplasms
Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Neoplasms
Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Neoplasms
Gene therapy in brain tumours: implications of the size of glioblastoma on its curability.
Neoplasms
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
Neoplasms
Gene therapy of epithelial ovarian cancer using adenoviral vectors.
Neoplasms
Gene therapy of established medullary thyroid carcinoma with herpes simplex viral thymidine kinase in a rat tumor model: relationship of bystander effect and antitumor efficacy.
Neoplasms
Gene therapy of liver tumors with human liver-specific nanoparticles.
Neoplasms
Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells.
Neoplasms
Gene therapy of neoplastic meningosis.
Neoplasms
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.
Neoplasms
Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.
Neoplasms
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-?B signaling improves the efficacy of immunotherapy in a brain cancer model.
Neoplasms
Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression.
Neoplasms
Genetic and biochemical modulation of 5-fluorouracil through the overexpression of thymidine kinase: an in-vitro study.
Neoplasms
Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
Neoplasms
Glial tumor cells deficient in thymidine kinase: isolation and characterization.
Neoplasms
Glioblastoma Bystander Cell Therapy: Improvements in Treatment and Insights into the Therapy Mechanisms.
Neoplasms
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Neoplasms
Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.
Neoplasms
Glucose transport and apoptosis after gene therapy with HSV thymidine kinase.
Neoplasms
GM-CSF raises serum levels of beta 2-microglobulin and thymidine kinase in patients with chronic lymphocytic leukaemia.
Neoplasms
Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment.
Neoplasms
Granulocyte-macrophage colony-stimulating factor in a combination gene therapy strategy for head and neck cancer.
Neoplasms
Graphene oxide-hydroxyapatite nanocomposites effectively deliver HSV-TK suicide gene to inhibit human breast cancer growth.
Neoplasms
Herpes simplex thymidine kinase gene transfer is required for complete regression of murine colon adenocarcinoma.
Neoplasms
Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy.
Neoplasms
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.
Neoplasms
Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.
Neoplasms
Herpes simplex virus thymidine kinase/ganciclovir-mediated killing of tumor cell induces tumor-specific cytotoxic T cells in mice.
Neoplasms
Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing.
Neoplasms
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Neoplasms
Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors.
Neoplasms
High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma.
Neoplasms
High levels of inactive thymidine kinase 1 polypeptide detected in sera from dogs with solid tumours by immunoaffinity methods: Implications for in vitro diagnostics.
Neoplasms
High Mobility Group Box2 Promoter-controlled Suicide Gene Expression Enables Targeted Glioblastoma Treatment.
Neoplasms
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
Neoplasms
High-intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene-loaded ultrasound-targeted microbubbles improved survival of rabbit with VX2 liver tumor.
Neoplasms
High-level transgene expression mediated by the piggyBac transposon enhances transgenic therapeutic effects in cervical cancer xenografts.
Neoplasms
Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene.
Neoplasms
Histologic, biochemical, and clinical parameters for monitoring multiple myeloma.
Neoplasms
Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression.
Neoplasms
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
Neoplasms
Homogeneous assay for real-time and simultaneous detection of thymidine kinase 1 and deoxycytidine kinase activities.
Neoplasms
Hormonal effects on thymidine kinase and thymidylate kinase activity of estrogen-dependent tumors in the rat.
Neoplasms
Hormonal induction of transfected genes depends on DNA topology.
Neoplasms
HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.
Neoplasms
HSV-1 viral oncolysis and molecular imaging with PET.
Neoplasms
HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells.
Neoplasms
HSV-TK/GCV cancer suicide gene therapy by a designed recombinant multifunctional vector.
Neoplasms
HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1?pAFP-TK and targeted killing effect.
Neoplasms
Human adipose tissue-derived mesenchymal stromal cells as vehicles for tumor bystander effect: a model based on bioluminescence imaging.
Neoplasms
HVJ-liposome-mediated transfection of HSVtk gene driven by AFP promoter inhibits hepatic tumor growth of hepatocellular carcinoma in SCID mice.
Neoplasms
Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy.
Neoplasms
Identification and characterization of the conserved nucleoside-binding sites in the Epstein-Barr virus thymidine kinase.
Neoplasms
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Neoplasms
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.
Neoplasms
Imaging Chemically Modified Adenovirus for Targeting Tumors Expressing Integrin {alpha}v{beta}3 in Living Mice with Mutant Herpes Simplex Virus Type 1 Thymidine Kinase PET Reporter Gene.
Neoplasms
Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET.
Neoplasms
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.
Neoplasms
Imaging Metformin Efficacy as Add-On Therapy in Cells and Mouse Models of Human EGFR Glioblastoma.
Neoplasms
Imaging of cellular proliferation in liver metastasis by [18F]fluorothymidine positron emission tomography: effect of therapy.
Neoplasms
Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats.
Neoplasms
Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.
Neoplasms
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.
Neoplasms
Imaging the expression of transfected genes in vivo.
Neoplasms
Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis.
Neoplasms
Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery.
Neoplasms
Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy for Bladder Cancer.
Neoplasms
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.
Neoplasms
Immunomodulation of glioma cells after gene therapy: induction of major histocompatibility complex class I but not class II antigen in vitro.
Neoplasms
Improvement of nonviral gene therapy by Epstein-Barr virus (EBV)-based plasmid vectors.
Neoplasms
In situ gene transfer and suicide gene therapy of gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in dogs.
Neoplasms
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
Neoplasms
In situ use of suicide genes for cancer therapy.
Neoplasms
In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma.
Neoplasms
In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy.
Neoplasms
In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy.
Neoplasms
In vitro mammalian mutagenesis as a model for genetic lesions in human cancer.
Neoplasms
In vitro thymidine kinase/ganciclovir-based suicide gene therapy using replication defective herpes simplex virus-1 against leukemic B-cell malignancies (MCL, HCL, B-CLL).
Neoplasms
In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene.
Neoplasms
In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer.
Neoplasms
In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats.
Neoplasms
In vivo efficacy of folate-targeted lipid-protamine-DNA (LPD-PEG-Folate) complexes in an immunocompetent syngeneic model for breast adenocarcinoma.
Neoplasms
In vivo evaluation of 2'-deoxy-2'-[(18)F]fluoro-5-iodo-1-beta-D-arabinofuranosyluracil ([18F]FIAU) and 2'-deoxy-2'-[18F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([18F]FEAU) as markers for suicide gene expression.
Neoplasms
In vivo gene delivery to tumor cells by transferrin-streptavidin-DNA conjugate.
Neoplasms
In vivo Imaging of the Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors.
Neoplasms
In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.
Neoplasms
In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells.
Neoplasms
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
Neoplasms
In vivo surgical resection plus adjuvant gene therapy in the treatment of mammary and prostate cancer.
Neoplasms
In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors.
Neoplasms
Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy.
Neoplasms
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Neoplasms
Increased activities of thymidine kinase isozymes in human mammary tumours.
Neoplasms
Increased activities of thymidylate synthetase and thymidine kinase in human thyroid tumors.
Neoplasms
Increased activity of thymidine kinase isozyme in human colon tumor.
Neoplasms
Increased anti-tumor effect by a combination of HSV thymidine kinase suicide gene therapy and interferon-gamma/GM-CSF cytokine gene therapy in CT26 tumor model.
Neoplasms
Increased efficiency of cisplatin-resistant cell lines to DNA-mediated gene transfer with cationic liposome.
Neoplasms
Increased intratumoral fluorothymidine uptake levels following multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft model.
Neoplasms
Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma.
Neoplasms
INCREASED STABILITY OF TEMPLATES FOR SOME ENZYMES OF DNA SYNTHESIS IN TUMORS: DEOXYCYTIDYLATE DEAMINASE, THYMIDINE AND THYMIDYLATE KINASE.
Neoplasms
Inducible expression of herpes simplex virus thymidine kinase increases sensitivity to ganciclovir but does not enhance bystander effect in breast cancer cells.
Neoplasms
Induction of ornithine decarboxylase, tyrosine aminotransferase, and thymidine kinase by glucocorticoid in isolated, perfused liver after tumor inoculation.
Neoplasms
Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies.
Neoplasms
Induction of thymidine kinase activity in a spontaneously enzyme-deficient murine tumor cell line by exposure in vivo to the DNA-hypomethylating agent 5-aza-2'-deoxycytidine: implications for mechanisms of tumor progression.
Neoplasms
Influence of different promoters on the expression of tumor-necrosis-factor-alpha in ls174t human colon-carcinoma cells.
Neoplasms
Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter.
Neoplasms
Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment.
Neoplasms
Inhibition of thymidine kinase in cultured mammary tumor cells by the chemopreventive organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.
Neoplasms
Inhibition of tumor growth by direct intratumoral gene transfer of herpes simplex virus thymidine kinase gene with DNA-liposome complexes.
Neoplasms
Inhibition of tumor growth in liver epithelial cells transfected with a transforming growth factor alpha antisense gene.
Neoplasms
Inhibitory effect of lignin-related pine cone extract on cell proliferating enzyme activity of spontaneous mammary tumours in mice.
Neoplasms
Innovative strategies for the treatment of thyroid cancer.
Neoplasms
INSM1 Promoter-Driven Adenoviral Herpes Simplex Virus Thymidine Kinase Cancer Gene Therapy for the Treatment of Primitive Neuroectodermal Tumors.
Neoplasms
Interleukin-2 as a modulator of 5-fluorouracil in hepatic arterial immunochemotherapy for liver metastases.
Neoplasms
Intracellular localization and sustained prodrug cell killing activity of TAT-HSVTK fusion protein in hepatocelullar carcinoma cells.
Neoplasms
Intracellular localization of Herpes simplex virus type 1 thymidine kinase fused to different fluorescent proteins depends on choice of fluorescent tag.
Neoplasms
Intracerebral Administration of Autologous Mesenchymal Stem Cells as HSV-TK Gene Vehicle for Treatment of Glioblastoma Multiform: Safety and Feasibility Assessment.
Neoplasms
Intrathecal gene therapy for malignant leptomeningeal neoplasia.
Neoplasms
Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system.
Neoplasms
Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: results of a phase I clinical trial.
Neoplasms
Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir.
Neoplasms
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy.
Neoplasms
Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes.
Neoplasms
Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
Neoplasms
Investigation on traditional medicines of Guarany Indio and studies on diterpenes from Scoparia dulcis.
Neoplasms
Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase.
Neoplasms
Journey of 2'-deoxy-2'-fluoro-5-methyl-1-?-D-arabinofuranosyluracil (FMAU): from Antiviral Drug to PET Imaging Agent.
Neoplasms
Killing effect of the herpes simplex virus thymidine kinase/ganciclovir enzyme/prodrug system on human nasopharyngeal carcinoma cells.
Neoplasms
Lack of correlation between thymidine kinase activity and changes of DNA synthesis with tumour age: an in vivo study in Ehrlich ascites tumour.
Neoplasms
Leucovorin modulation of 5-iododeoxyuridine radiosensitization: a phase I study.
Neoplasms
Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.
Neoplasms
Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors.
Neoplasms
Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats.
Neoplasms
Liquid chromatography-tandem mass spectrometry method for quantification of thymidine kinase activity in human serum by monitoring the conversion of 3'-deoxy-3'-fluorothymidine to 3'-deoxy-3'-fluorothymidine monophosphate.
Neoplasms
Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus.
Neoplasms
Local inflammation and devascularization--in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma.
Neoplasms
Long-term connexin-mediated bystander effect in highly tumorigenic human cells in vivo in herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Neoplasms
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.
Neoplasms
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
Neoplasms
Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA.
Neoplasms
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.
Neoplasms
Low-dose cisplatin converts the tumor microenvironment into a permissive state for HSVtk-induced antitumor immunity in HPV16-related tonsillar carcinoma.
Neoplasms
Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment.
Neoplasms
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
Neoplasms
Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene.
Neoplasms
Mechanisms of the escape phase of myeloma.
Neoplasms
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.
Neoplasms
Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies.
Neoplasms
Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
Neoplasms
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Neoplasms
Microchip immunoaffinity electrophoresis of antibody-thymidine kinase 1 complex.
Neoplasms
MicroPET imaging of prostate cancer in LNCAP-SR39TK-GFP mouse xenografts.
Neoplasms
Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor.
Neoplasms
Minicircles for a two-step blood biomarker and PET imaging early cancer detection strategy.
Neoplasms
miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy.
Neoplasms
miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy.
Neoplasms
Modulation of 5-fluorouracil resistance in human colon tumor cell lines by azidothymidine.
Neoplasms
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Neoplasms
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.
Neoplasms
Molecular imaging of brain tumors personal experience and review of the literature.
Neoplasms
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.
Neoplasms
Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation.
Neoplasms
Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs.
Neoplasms
Monitoring of bystander effect of herpes simplex virus thymidine kinase/acyclovir system using fluorescence resonance energy transfer technique.
Neoplasms
Monitoring of gliomas in vivo by diffusion MRI and (1)H MRS during gene therapy-induced apoptosis: interrelationships between water diffusion and mobile lipids.
Neoplasms
Monitoring Response to Radiotherapy in Human Squamous Cell Cancer Bearing Nude Mice: Comparison of 2'-deoxy-2'-[(18)F]fluoro-D: -glucose (FDG) and 3'-[ (18)F]fluoro-3'-deoxythymidine (FLT).
Neoplasms
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.
Neoplasms
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma.
Neoplasms
Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells.
Neoplasms
Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033.
Neoplasms
Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells.
Neoplasms
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Neoplasms
Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene.
Neoplasms
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Neoplasms
Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir.
Neoplasms
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Neoplasms
Muscle-invasive bladder cancer is characterized by overexpression of thymidine kinase 1.
Neoplasms
Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats.
Neoplasms
Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.
Neoplasms
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Neoplasms
Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies.
Neoplasms
Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
Neoplasms
Neuron-specific enolase and thymidine kinase as an aid to the diagnosis and treatment monitoring of small cell lung cancer.
Neoplasms
NF-Y-mediated trans-activation of the human thymidine kinase promoter is closely linked to activation of cyclin-dependent kinase.
Neoplasms
Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir.
Neoplasms
Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model.
Neoplasms
Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma.
Neoplasms
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Neoplasms
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Neoplasms
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Neoplasms
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Neoplasms
Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells.
Neoplasms
Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity.
Neoplasms
NT-polyplex: a new tool for therapeutic gene delivery to neuroblastoma tumors.
Neoplasms
Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix.
Neoplasms
Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat.
Neoplasms
On the possible contribution of DNA hypomethylation to the induction of high frequency and heritable drug-induced alterations in the malignant phenotype.
Neoplasms
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Neoplasms
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.
Neoplasms
Oncolytic efficacy of thymidine kinase-deleted vaccinia virus strain Guang9.
Neoplasms
Oncoselective parvoviral vector-mediated gene therapy of cancer.
Neoplasms
Optimizing suicide gene therapy for head and neck cancer.
Neoplasms
Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer.
Neoplasms
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Neoplasms
Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene.
Neoplasms
Overproduction of the protein product of a nonselected foreign gene carried by an adenovirus vector.
Neoplasms
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Neoplasms
Papers to appear in forthcoming issues
Neoplasms
Partial regression, yet incomplete eradication of mammary tumors in transgenic mice by retrovirally mediated HSVtk transfer 'in vivo'.
Neoplasms
Patterns of DNA methylation and gene expression in human tumor cell lines.
Neoplasms
Periodate-oxidized adenosine induction of murine thymidine kinase: role of DNA methylation in the generation of tumor cell heterogeneity.
Neoplasms
PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [18F]FHBG.
Neoplasms
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Neoplasms
Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside.
Neoplasms
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors.
Neoplasms
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer.
Neoplasms
Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma.
Neoplasms
Plasma and CSF pharmacokinetics of ganciclovir in nonhuman primates.
Neoplasms
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
Neoplasms
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
Neoplasms
Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.
Neoplasms
Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy.
Neoplasms
Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK.
Neoplasms
Positron emission tomography of herpes simplex virus 1 oncolysis.
Neoplasms
Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine.
Neoplasms
Potential of bromovinyldeoxyuridine in anticancer chemotherapy.
Neoplasms
Potential of gene therapy for the treatment of pituitary tumors.
Neoplasms
Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin.
Neoplasms
Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma.
Neoplasms
Preclinical evaluation of the penciclovir analog 9-(4-[(18)F]fluoro-3-hydroxymethylbutyl)guanine for in vivo measurement of suicide gene expression with PET.
Neoplasms
Preclinical studies on suicide gene therapy for head/neck cancer: a novel method for evaluation of treatment efficacy.
Neoplasms
Preclinical testing of recombinant adenoviral herpes simplex virus-thymidine kinase gene therapy for central nervous system malignancies.
Neoplasms
Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir.
Neoplasms
Preservation of the bystander cytocidal effect of irradiated herpes simplex virus thymidine kinase (HSV-tk) modified tumor cells.
Neoplasms
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Neoplasms
Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".
Neoplasms
Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer.
Neoplasms
Prognostic importance of thymidine kinase in colorectal and breast cancer.
Neoplasms
Prognostic of DNA-synthesizing enzyme activities (thymidine kinase and thymidylate synthase) in 908 T1-T2, N0-N1, M0 breast cancers: a retrospective multicenter study.
Neoplasms
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
Neoplasms
Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.
Neoplasms
Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors.
Neoplasms
Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer.
Neoplasms
Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma.
Neoplasms
Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy.
Neoplasms
Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines.
Neoplasms
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker.
Neoplasms
Properties of thymidine kinase partially purified from human adrenal glands.
Neoplasms
Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755.
Neoplasms
Protein synthesis and tumorigenicity of the cytoplasmic hybrid between rat yolk sac tumor and mouse fibroblastic cell line.
Neoplasms
Pseudotyped retrovectors for tumor-specific delivery of toxic suicide genes.
Neoplasms
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Neoplasms
Purification of thymidine kinase activity from Yaba virus induced tumors.
Neoplasms
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Neoplasms
Purified herpes simplex virus thymidine kinase retroviral particles: III. Characterization of bystander killing mechanisms in transfected tumor cells.
Neoplasms
Purkinje cell protein-2 cis-elements mediate repression of T3-dependent transcriptional activation.
Neoplasms
Pyrimidine nucleosides in molecular PET imaging of tumor proliferation.
Neoplasms
Pyrimidine nucleotide metabolism in human colon carcinomas: comparison of normal tissues, primary tumors and xenografts.
Neoplasms
Quantifying the Activity of Adenoviral E1A CR2 Deletion Mutants Using Renilla Luciferase Bioluminescence and 3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Imaging.
Neoplasms
Quantitative 1H nuclear magnetic resonance diffusion spectroscopy of BT4C rat glioma during thymidine kinase-mediated gene therapy in vivo: identification of apoptotic response.
Neoplasms
Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation.
Neoplasms
Radiolabeled nucleoside analogues for PET imaging of HSV1-tk gene expression.
Neoplasms
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Neoplasms
Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963.
Neoplasms
Real-time visualizing and tracing of HSV-TK/GCV suicide gene therapy by near-infrared fluorescent quantum dots.
Neoplasms
Recent developments in the prevention and treatment of Epstein-Barr virus-associated lymphoproliferative diseases.
Neoplasms
Receptor-mediated gene delivery using the Fab fragments of anti-epidermal growth factor receptor antibodies: improved immunogene approach.
Neoplasms
Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells.
Neoplasms
Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.
Neoplasms
Recombinant interferon alpha2a synergistically enhances ganciclovir-mediated tumor cell killing in the herpes simplex virus thymidine kinase system.
Neoplasms
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography.
Neoplasms
Refined human artificial chromosome vectors for gene therapy and animal transgenesis.
Neoplasms
Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy.
Neoplasms
Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage.
Neoplasms
Regulation of HSVtk gene by endogenous microRNA-122a in liver cell lines as suicide gene therapy.
Neoplasms
Relative activities of thymidylate synthetase and thymidine kinase in human mammary tumours.
Neoplasms
Relative activities of thymidylate synthetase and thymidine kinase in rat tissues.
Neoplasms
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy.
Neoplasms
Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics.
Neoplasms
Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy.
Neoplasms
Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase.
Neoplasms
Research on application value of combined detection of serum CA125, HE4 and TK1 in the diagnosis of ovarian cancer.
Neoplasms
Resistance developing after long-term ganciclovir prodrug treatment in a preclinical model of NSCLC.
Neoplasms
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.
Neoplasms
Retargeting of adenoviral vectors to neurons using the Hc fragment of tetanus toxin.
Neoplasms
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Neoplasms
Reverse transcriptase and thymidine kinase as markers for tumorigenicity and viral contamination of cells.
Neoplasms
Ribozyme-mediated selective killing of cancer cells expressing carcinoembryonic antigen RNA by targeted trans-splicing.
Neoplasms
Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines.
Neoplasms
Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer.
Neoplasms
Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity.
Neoplasms
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Neoplasms
Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7.
Neoplasms
Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.
Neoplasms
Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene.
Neoplasms
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.
Neoplasms
Selective incorporation of iododeoxyuridine into DNA of hepatic metastases versus normal human liver.
Neoplasms
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene.
Neoplasms
Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene.
Neoplasms
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Neoplasms
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Neoplasms
Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.
Neoplasms
Sensitive nonradiometric method for determining thymidine kinase 1 activity.
Neoplasms
Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
Neoplasms
Serial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer.
Neoplasms
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Neoplasms
Serological thymidine kinase 1 (STK1) indicates an elevated risk for the development of malignant tumours.
Neoplasms
Serological thymidine kinase 1 is a biomarker for early detection of tumours--a health screening study on 35,365 people, using a sensitive chemiluminescent dot blot assay.
Neoplasms
Serum detection of thymidine kinase 1 as a means of early detection of lung cancer.
Neoplasms
Serum soluble CD27, but not thymidine kinase, is an independent prognostic factor for outcome in indolent non-Hodgkin's lymphoma.
Neoplasms
Serum thymidine kinase 1 activity in solid tumor (breast and colorectal cancer) patients treated with adjuvant chemotherapy.
Neoplasms
Serum thymidine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease.
Neoplasms
Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1,247 cancer patients in routine clinical settings.
Neoplasms
Serum thymidine kinase 1 is a reliable maker for the assessment of the risk of developing malignancy: A case report.
Neoplasms
Serum thymidine kinase 1 is associated with Gleason score of patients with prostate carcinoma.
Neoplasms
Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.
Neoplasms
Serum thymidine kinase 1 reflects the progression of pre-malignant and malignant tumors during therapy.
Neoplasms
Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial.
Neoplasms
Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma.
Neoplasms
Serum thymidine kinase activity in clinically healthy and diseased horses: A potential marker for lymphoma.
Neoplasms
Serum thymidine kinase activity in dogs with malignant lymphoma: a potent marker for prognosis and monitoring the disease.
Neoplasms
Serum thymidine kinase as a marker of disease activity in patients with multiple myeloma.
Neoplasms
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Neoplasms
Serum thymidine kinase in colorectal neoplasia.
Neoplasms
Serum thymidine kinase is associated with gastric adenocarcinoma.
Neoplasms
Serum thymidine kinase levels in cancer patients.
Neoplasms
Serum TK levels in CLL identify Binet stage A patients within biologically defined prognostic subgroups most likely to undergo disease progression.
Neoplasms
Serum TK1 is a more reliable marker than CEA and AFP for cancer screening survey in a study of 56,286 people.
Neoplasms
Serum tumour markers in human prostatic carcinoma. The value of a marker panel for prognostic information.
Neoplasms
Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents.
Neoplasms
Short-term neuropathological aspects of in vivo suicide gene transfer to the F98 rat glioblastoma using liposomal and viral vectors.
Neoplasms
Silk-elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors.
Neoplasms
Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging.
Neoplasms
Simultaneous imaging of temporal changes of NF-?B activity and viable tumor cells in Huh7/NF-?B-tk-luc2/rfp tumor-bearing mice.
Neoplasms
siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine.
Neoplasms
Small Animal PET Imaging of hTERT RNA-Targeted HSV1-tk Gene Expression with Trans-Splicing Ribozyme.
Neoplasms
Some characteristics of fetal and adult isoenzymes of thymidine kinase in human breast cancers.
Neoplasms
SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo.
Neoplasms
Specific recognition of cytosolic thymidine kinase in the human lung tumor by monoclonal antibodies raised against recombinant human thymidine kinase.
Neoplasms
Specific regression of human cancer cells by ribozyme-mediated targeted replacement of tumor-specific transcript.
Neoplasms
Specific viral antigens in rat cells transformed by herpes simplex virus type 2 and in rat tumors induced by inoculation of transformed cells.
Neoplasms
SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1).
Neoplasms
Stable transgenic expression of IL-2 and HSV1-tk by single and fusion tumor cell lines bearing EWS/FLI-1 chimeric genes.
Neoplasms
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy.
Neoplasms
Strategies for gene therapy.
Neoplasms
Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles.
Neoplasms
Suicide Gene Therapy for Oral Squamous Cell Carcinoma.
Neoplasms
Suicide gene therapy for urogenital cancer: current outcome and prospects.
Neoplasms
Suicide gene therapy of chemically induced mammary tumor in rat: efficacy and distant bystander effect.
Neoplasms
Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line in vitro.
Neoplasms
Suicide gene therapy using reducible poly (oligo-D-arginine) for the treatment of spinal cord tumors.
Neoplasms
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Neoplasms
Suppression of tumorigenesis and tumor-growth of mouse mammary-glands by a traditional chinese herbal medicine, sho-saiko-to.
Neoplasms
Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.
Neoplasms
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Neoplasms
Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea.
Neoplasms
Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan.
Neoplasms
Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells.
Neoplasms
Synthesis and application of poly(ethylene glycol)-co-poly(?-amino ester) copolymers for small cell lung cancer gene therapy.
Neoplasms
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
Neoplasms
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
Neoplasms
Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer.
Neoplasms
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.
Neoplasms
Synthesis of 2-amino-6-(4-[11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers.
Neoplasms
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Neoplasms
Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene: an unexpected chelating effect.
Neoplasms
Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents.
Neoplasms
Synthesis, biological evaluation, and radioiodination of halogenated closo-carboranylthymidine analogues.
Neoplasms
Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1.
Neoplasms
Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes.
Neoplasms
Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma.
Neoplasms
Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.
Neoplasms
T cell suicide gene therapy to aid haematopoietic stem cell transplantation.
Neoplasms
Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies.
Neoplasms
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Neoplasms
Targeted gene therapy for cancer: herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells.
Neoplasms
Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using anti-epidermal growth factor receptor antibody: immunogene approach.
Neoplasms
Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors.
Neoplasms
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
Neoplasms
Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
Neoplasms
Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.
Neoplasms
Technical evaluation of thymidine kinase assay in cytosols from breast cancers. EORTC Receptor Study Group Report.
Neoplasms
Temporal changes in gene expression following cryogenic rat brain injury.
Neoplasms
TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection.
Neoplasms
Test of ovarian cancer multiplex xMAP technology panel.
Neoplasms
The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.
Neoplasms
The anti-tumor effect of human monocyte-derived dendritic cells loaded with HSV-TK/GCV induced dying cells.
Neoplasms
The Association of Serum Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Thymidine Kinase, and Tissue Polypeptide Specific Antigen with Outcomes of Patients with Metastatic Colorectal Cancer Treated with Bevacizumab: a Retrospective Study.
Neoplasms
The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions.
Neoplasms
The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody.
Neoplasms
The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects.
Neoplasms
The Current State of Clinical Application of Serum Biomarkers for Canine Lymphoma.
Neoplasms
The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.
Neoplasms
The drug verapamil inhibits bystander killing but not cell suicide in thymidine kinase-ganciclovir prodrug-activated gene therapy.
Neoplasms
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
Neoplasms
The effect of promoter strength in adenoviral vectors containing herpes simplex virus thymidine kinase on cancer gene therapy in vitro and in vivo.
Neoplasms
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
Neoplasms
The EIIAPA Chimeric Promoter for Tumor Specific Gene Therapy of Hepatoma.
Neoplasms
The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.
Neoplasms
The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase.
Neoplasms
The evaluation of adenoviral p53-mediated bystander effect in gene therapy of cancer.
Neoplasms
The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.
Neoplasms
The genome of canarypox virus.
Neoplasms
The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models.
Neoplasms
The inhibition of thymidine kinase in glial tumor cells by an amino sugar, D-glucosamine.
Neoplasms
The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene.
Neoplasms
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Neoplasms
The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells.
Neoplasms
The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction.
Neoplasms
The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers.
Neoplasms
The presence of "fetal" thymidine kinase in human tumors.
Neoplasms
The processed pseudogene of mouse thymidine kinase is active after transfection.
Neoplasms
The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line.
Neoplasms
The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
Neoplasms
The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells.
Neoplasms
The role of herpes simplex virus thymidine kinase in the treatment of solid tumours.
Neoplasms
The role of herpes simplex virus-1 thymidine kinase alanine 168 in substrate specificity.
Neoplasms
The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene.
Neoplasms
The role of thymidine kinase activity in murine colon tumours treated with 5-fluorouracil.
Neoplasms
The role of thymidine kinase in cancer diseases.
Neoplasms
The study of different chromosomal aberrations, CD38 and ZAP-70 in chronic lymphocytic leukemia patients.
Neoplasms
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters.
Neoplasms
The topoisomerase II-inhibitor NC-190 reduces the level of thymidine kinase mRNA in murine tumor cells.
Neoplasms
The treatment of malignant mesothelioma with a gene modified cancer cell line: a phase I study.
Neoplasms
The uptake of 3'-deoxy-3'-[(18)F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels.
Neoplasms
The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels.
Neoplasms
Theranostic Imaging of Cancer Gene Therapy.
Neoplasms
Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.
Neoplasms
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
Neoplasms
Thymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment.
Neoplasms
Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis.
Neoplasms
Thymidine kinase 1 as a tumor biomarker: technical advances offer new potential to an old biomarker.
Neoplasms
Thymidine kinase 1 combined with CEA, CYFRA21-1 and NSE improved its diagnostic value for lung cancer.
Neoplasms
Thymidine kinase 1 expression in atypical ductal hyperplasia significantly differs from usual ductal hyperplasia and ductal carcinoma in situ: A useful tool in tumor therapy management.
Neoplasms
Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker.
Neoplasms
Thymidine kinase 1 through the ages: a comprehensive review.
Neoplasms
Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study.
Neoplasms
Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker.
Neoplasms
Thymidine kinase and cancer monitoring.
Neoplasms
Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model.
Neoplasms
Thymidine kinase as a predictor of response to chemotherapy in advanced breast cancer.
Neoplasms
Thymidine kinase expression. A marker for malignant cells.
Neoplasms
Thymidine Kinase Gene Modified Bone Marrow Mesenchymal Stem Cells as Vehicles for Anti-tumor Therapy.
Neoplasms
Thymidine kinase in breast cancer.
Neoplasms
Thymidine kinase in malignant melanoma.
Neoplasms
Thymidine kinase is expressed differently in transformed versus normal-cells - a novel test for malignancy.
Neoplasms
Thymidine kinase levels correlate with prognosis in aggressive lymphoma and can discriminate patients with a clinical suspicion of indolent to aggressive transformation.
Neoplasms
Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo.
Neoplasms
Thymidine Kinase Type 1 and C-Reactive Protein Concentrations in Dogs with Spontaneously Occurring Cancer.
Neoplasms
Thymidine kinase, DNA synthesis and cancer.
Neoplasms
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Neoplasms
Thymidine Kinase-1 as Additional Diagnostic Marker of Prostate Cancer.
Neoplasms
Thymidine Kinase: A Biomarker for Recently Diagnosed Acute Leukemia in Pediatric Patients According to the Cell Line Involved.
Neoplasms
Thymidine kinase: a tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications.
Neoplasms
Thymidine kinase: diagnostic and prognostic potential.
Neoplasms
Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo.
Neoplasms
Thymidylate synthetase and thymidine kinase activities and methotrexate cytotoxicity during growth of L1210 and Ehrlich ascites tumor.
Neoplasms
Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems.
Neoplasms
Titration of Variant HSV1-tk Gene Expression to Determine the Sensitivity of 18F-FHBG PET Imaging in a Prostate Tumor.
Neoplasms
Total vascular exclusion of the liver enhances the efficacy of retroviral-mediated associated thymidine kinase and interleukin-2 genes transfer against multiple hepatic tumors in rats.
Neoplasms
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.
Neoplasms
Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer.
Neoplasms
Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors.
Neoplasms
Tracing transgene expression in cancer gene therapy: a requirement for rational progress in the field.
Neoplasms
Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2.
Neoplasms
Trans-complementing adenoviral vectors for oncolytic therapy of malignant melanoma.
Neoplasms
Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide from HIV-1 Tat.
Neoplasms
Transcription initiation of transfected mouse mammary tumor virus LTR DNA is regulated by glucocorticoid hormones.
Neoplasms
Transcriptional targeting of acute hypoxia in the tumour stroma is a novel and viable strategy for cancer gene therapy.
Neoplasms
Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries.
Neoplasms
Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector.
Neoplasms
Transduction of a fiber-mutant adenovirus for the HSVtk gene highly augments the cytopathic effect towards gliomas.
Neoplasms
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
Neoplasms
Transduction of the herpes thymidine kinase gene into premalignant murine mammary epithelial cells renders subsequent breast cancers responsive to ganciclovir therapy.
Neoplasms
Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy.
Neoplasms
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.
Neoplasms
Transgenic mouse models for gonadal tumorigenesis.
Neoplasms
Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial.
Neoplasms
Treatment of medullary thyroid carcinoma by combined expression of suicide and interleukin-2 genes.
Neoplasms
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.
Neoplasms
Treatment of rat experimental brain tumors by herpes simplex virus thymidine kinase gene-transduced allogeneic tumor cells and ganciclovir.
Neoplasms
Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery.
Neoplasms
Tumor 3'-Deoxy-3'-18F-Fluorothymidine (18F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18F-FLT PET Studies in Lung Tumors.
Neoplasms
Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.
Neoplasms
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Neoplasms
Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.
Neoplasms
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.
Neoplasms
Tumor markers in pleural effusions.
Neoplasms
Tumor markers in staging and prognosis of colorectal carcinoma.
Neoplasms
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Neoplasms
Tumor markers. Consensus Conference on Diagnosis and Prognostic Parameters in Localized Prostate Cancer. Stockholm, Sweden, May 12-13, 1993.
Neoplasms
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Neoplasms
Tumor Restrictive Suicide Gene Therapy for Glioma Controlled by the FOS Promoter.
Neoplasms
Tumor Tropism of Intravenously Injected Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model.
Neoplasms
Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy.
Neoplasms
Tumor-associated thymidine kinase in the sera of rats with transplanted hepatomas.
Neoplasms
Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.
Neoplasms
Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter.
Neoplasms
Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET.
Neoplasms
Tumor-specific promoter-driven adenoviral therapy for insulinoma.
Neoplasms
Tumor-targeted Salmonella as a novel anticancer vector.
Neoplasms
Tumor-Targeted Salmonella: Strain Development and Expression of the HSV-tK Effector Gene.
Neoplasms
Tumour markers as prognostic aids in prostatic carcinoma.
Neoplasms
Two forms of thymidine kinase in normal and tumor tissues of animals.
Neoplasms
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Neoplasms
Unavailability of thymidine kinase does not preclude the use of German comprehensive prognostic index: results of an external validation analysis in early chronic lymphocytic leukemia and comparison with MD Anderson Cancer Center model.
Neoplasms
Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase.
Neoplasms
Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir.
Neoplasms
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Neoplasms
Uridine kinase, adenylate kinase, and guanase in human lung tumors.
Neoplasms
Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer.
Neoplasms
Use of protamine to augment adenovirus-mediated cancer gene therapy.
Neoplasms
Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.
Neoplasms
Use of the mouse mammary tumor virus long terminal repeat to promote steroid-inducible expression of v-mos.
Neoplasms
Use of tumor-targeting trans-splicing ribozyme for cancer treatment.
Neoplasms
Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC.
Neoplasms
Using fluorodeoxythymidine to monitor anti-EGFR inhibitor therapy in squamous cell carcinoma xenografts.
Neoplasms
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Neoplasms
Vaccinia as a vector for gene delivery.
Neoplasms
Vaccinia Virus Shuffling: deVV5, a Novel Chimeric Poxvirus with Improved Oncolytic Potency.
Neoplasms
Valproic acid enhances anti-tumor effect of mesenchymal stem cell mediated HSV-TK gene therapy in intracranial glioma.
Neoplasms
Variable responsiveness of hormone-inducible hybrid genes in different cell lines.
Neoplasms
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.
Neoplasms
Vascular damage and anti-angiogenic effects of tumor vessel-targeted adenovirus-mediated herpes simplex virus thymidine kinase gene.
Neoplasms
Viral mediated gene therapy for the management of metastatic thyroid carcinoma.
Neoplasms
Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model.
Neoplasms
Virus-associated tumor imaging by induction of viral gene expression.
Neoplasms
Virus-free transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment induces tumor cell death.
Neoplasms
Viruses in the treatment of brain tumors.
Neoplasms
Visualization of gene therapy with a liver cancer-targeted adeno-associated virus 3 vector.
Neoplasms
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins.
Neoplasms
VP22 does not significantly enhance enzyme prodrug cancer gene therapy as a part of a VP22-HSVTk-GFP triple fusion construct.
Neoplasms
VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death.
Neoplasms
VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment.
Neoplasms
[18F]-FLT Positron Emission Tomography can be used to image the response of sensitive tumors to PI3-Kinase inhibition with the novel agent GDC-0941.
Neoplasms
[A study of thymidine kinase activity in lung cancer tissue]
Neoplasms
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
Neoplasms
[Adenovirus-mediated herpes simplex virus thymidine kinase gene transference and combined drug therapy leads to apoptosis of human epithelial ovarian cancer cells]
Neoplasms
[Age-dependent characteristics of metabolism of DNA precursors in healthy women, patients with mastopathy and breast cancer]
Neoplasms
[An uncommon form of thymidine kinase in breast cancers]
Neoplasms
[Antitumor gene therapy using suicide genes]
Neoplasms
[Application of serum thymidine kinase 1 of 26 055 cases in health screening for early detection of premalignant/early malignant tumors].
Neoplasms
[Autoradiography reporter gene (Ad5-tk carrying HSV1-tk gene) expression imaging in rat myocardium]
Neoplasms
[Changes in the replication apparatus and phosphorus-containing metabolite pool in experimental tumors in animals during development]
Neoplasms
[Clinical value of thymidine kinase activities in sera and tumor tissues of patients with colorectal cancer]
Neoplasms
[Close relation between fetal thymidine kinase and thymidylate kinase activities in breast cancer]
Neoplasms
[Delivery of "suicide" thymidine kinase gene of herpes virus in the complex with cationic peptide into human hepatoma cells in vitro]
Neoplasms
[Demonstration of fetal-type thymidine kinase in cancer of the breast]
Neoplasms
[Effect of pAdKDR-tk suicide gene system on tumor vascular endothelial cells in nude mice with nasopharyngeal carcinoma]
Neoplasms
[Effect of the herpes simplex virus I-thymidine kinase gene-ganciclovir system on the transplant of human ovarian cancer on the omentum of nude mice]
Neoplasms
[Effect of total parenteral nutrition on the nutritional status and immunocompetence in host and on the tumor growth]
Neoplasms
[Evaluation of the effectiveness of determining thymidine kinase activity in the differential diagnosis of CNS tumors]
Neoplasms
[Experimental studies on the characteristics of suicide gene system HSV-tk/GCV and its effect on dendritic cells]
Neoplasms
[Gene therapy for cancer]
Neoplasms
[Gene therapy for cerebral tumors: use of an adenovirus in the glioma C6 rat model]
Neoplasms
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
Neoplasms
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
Neoplasms
[Gene therapy of primary cancers of the liver: hopes and realities]
Neoplasms
[Gene transfer and radiotherapy]
Neoplasms
[Generation of a trans-complementable defective recombinant provirus and loading a transgene]
Neoplasms
[Hypoxia augments the killing effect of herpes simplex virus thymidine kinase gene expression actuated by the promoter of the vascular endothelial growth factor gene on human hepatocellular tumor cells]
Neoplasms
[In vivo study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) in meningeal dissemination of malignant tumor]
Neoplasms
[Inhibitory effect of ganciclovir on the HSV1-tk positive subcutaneous tumors transplanted with human ovarian cancer in nude mice]
Neoplasms
[Killing effect of adenovirus vector-mediated herpes simplex virus thymidine kinase gene recombinant construct on various cancer cells]
Neoplasms
[Molecular imaging for PET-CT reporter gene in breast adenocarcinoma (HSV1-tk) of subcutaneous xenografts in living nude mice]
Neoplasms
[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others]
Neoplasms
[Oncolytic poxviruses].
Neoplasms
[Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]
Neoplasms
[Prognostic value of fetal thymidine kinase measurements in breast cancer]
Neoplasms
[Prognostic value of thymidine kinase in cancer of the breast]
Neoplasms
[Progress of EBNA1/oriP-based plasmid applied in gene therapy]
Neoplasms
[Prospect of gene therapy for metastatic foci of gastric cancer]
Neoplasms
[Recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene transfer followed by ganiciclovir administration effectively inhibits growth of human small-cell lung cancer in a murine xenotransplant model]
Neoplasms
[Research Progress on Prognostic Factors of Multiple Myeloma--Review].
Neoplasms
[Serum thymidine kinase activity of various cancer and HBV positive liver diseases]
Neoplasms
[Studies on evaluation of natural products for antiviral effects and their applications]
Neoplasms
[Studies on the mechanism of cytotoxicity of 5-fluorouracil--through impairment of metabolism]
Neoplasms
[Studies on the thymidine-triphosphate synthesis in malignant tumors. I. Effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis (author's trans)]
Neoplasms
[Studies on the thymidine-triphosphate synthesis in malignant tumors. II. Effect of hyperthermia, Vitamin K and Cytotoxic agents (author's transl)]
Neoplasms
[Study of DNA microarray chip of associated genes of hydatidiform mole]
Neoplasms
[Synthesis of GnRH analogs and their application in targeted gene delivery systems].
Neoplasms
[Targeted killing effect of mucin-1 single chain antibody targeting, lentivirus-mediated suicide gene therapy and ganciclovir in mucin-1+ ovarian epithelial carcinoma cells]
Neoplasms
[The effect of vinblastine on DNA metabolism in turnover cells (author's transl)]
Neoplasms
[The enzymatic activity of DNA metabolism of the blood in patients operated on in stomach cancer]
Neoplasms
[Therapeutic effect of ovarian intra-arterial infusion of GE7-delivery system-mediated HSVl-tk/ganciclovir gene therapy in a rat model of malignant ovarian tumor].
Neoplasms
[Thymidine kinase activity in mammary tumors of animals exposed to estradiol as an index of tumor hormone dependence]
Neoplasms
[Thymidine kinase activity, intracellular TTP content and DNA synthesis in transplantable hepatomas and lymphoid tissue of the host]
Neoplasms
[Thymidine kinase as a biological marker in neoplasms of the lung and mediastinum]
Neoplasms
[Thymidine kinase isozyme in cancer of the colon--correlation to pathology and prognosis]
Neoplasms
[Thymidine kinase isozyme in DMH-induced colon tumor in rats]
Neoplasms
[Transfer of the thymidine kinase gene in treating mouse TK- cells with DNA preparations from human tumor cells]
Neoplasms
[Treatment of experimental liver tumors by in vivo suicide gene transfer in rats]
Neoplasms
[Using the thymidine kinase gene in therapy of solid tumors]
Neoplasms
[Value of thymidine kinase in the prediction of response to treatment by chemotherapy or hormone therapy in breast cancer]
Neoplastic Cells, Circulating
Circulating Biomarkers of CDK4/6 Inhibitors Response in Hormone Receptor Positive and HER2 Negative Breast Cancer.
Neoplastic Cells, Circulating
Effect of NK cell immunotherapy on immune function in patients with hepatic carcinoma: A preliminary clinical study.
Neuralgia, Postherpetic
Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.
Neuroblastoma
Altered thymidine kinase or thymidylate synthetase activities in 5-fluoro deoxyuridine resistant variants of mouse neuroblastoma.
Neuroblastoma
Bystander-mediated regression of murine neuroblastoma via retroviral transfer of the HSV-TK gene.
Neuroblastoma
Characterization of tissue-specific transcription by the human synapsin I gene promoter.
Neuroblastoma
Correlations of dihydropyrimidine dehydrogenase, thymidine phosphorylase and thymidine kinase activities in strongly and weakly malignant cultured murine neuroblastoma cells.
Neuroblastoma
Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells.
Neuroblastoma
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Neuroblastoma
Effects of retroviral-mediated herpes simplex virus thymidine kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo.
Neuroblastoma
Experimental study of thymidine kinase gene therapy of neuroblastoma in vitro and in vivo.
Neuroblastoma
In vivo modelling of chemo-resistant neuroblastoma provides new insights into chemo-refractory disease and metastasis.
Neuroblastoma
NT-polyplex: a new tool for therapeutic gene delivery to neuroblastoma tumors.
Neuroectodermal Tumors, Primitive
INSM1 Promoter-Driven Adenoviral Herpes Simplex Virus Thymidine Kinase Cancer Gene Therapy for the Treatment of Primitive Neuroectodermal Tumors.
Neuroendocrine Tumors
Modifications to the INSM1 promoter to preserve specificity and activity for use in adenoviral gene therapy of neuroendocrine carcinomas.
Neuroendocrine Tumors
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Neurofibroma
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours - A prognostic test after surgical resection.
Neurofibrosarcoma
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours - A prognostic test after surgical resection.
Neurologic Manifestations
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
Newcastle Disease
Simultaneous Deletion of Virulence Factors and Insertion of Antigens into the Infectious Laryngotracheitis Virus Using NHEJ-CRISPR/Cas9 and Cre-Lox System for Construction of a Stable Vaccine Vector.
Newcastle Disease
Vaccination of chickens with a recombinant fowlpox virus containing the hemagglutinin-neuraminidase gene of Newcastle disease virus under the control of the fowlpox virus thymidine kinase promoter.
Obesity
Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats.
Ophthalmoplegia, Chronic Progressive External
Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders.
Ophthalmoplegia, Chronic Progressive External
Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.
Opportunistic Infections
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
Optic Atrophy, Hereditary, Leber
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Optic Nerve Diseases
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Orthomyxoviridae Infections
Responses of cattle, sheep and poultry to a recombinant vaccinia virus expressing a swine influenza haemagglutinin.
Osteosarcoma
A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.
Osteosarcoma
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.
Osteosarcoma
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.
Osteosarcoma
Bystander-mediated regression of osteosarcoma via retroviral transfer of the herpes simplex virus thymidine kinase and human interleukin-2 genes.
Osteosarcoma
Chemogene therapy: osteocalcin promoter-based suicide gene therapy in combination with methotrexate in a murine osteosarcoma model.
Osteosarcoma
D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
Osteosarcoma
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.
Osteosarcoma
Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives.
Osteosarcoma
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
Osteosarcoma
Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Osteosarcoma
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Osteosarcoma
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Osteosarcoma
Overexpression of c-fos increases recombination frequency in human osteosarcoma cells.
Osteosarcoma
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Osteosarcoma
Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
Osteosarcoma
Selective killing of osteosarcoma cells in culture after retroviral mediated gene transfer of a herpes simplex thymidine kinase suicide gene.
Osteosarcoma
Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine.
Osteosarcoma
Synthesis of conformationally North-locked pyrimidine nucleosides built on an oxabicyclo[3.1.0]hexane scaffold.
Osteosarcoma
Treatment of experimental osteosarcoma tumors in rat by herpes simplex thymidine kinase gene transfer and ganciclovir.
Osteosarcoma
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.
Osteosarcoma
[Experimental research in vitro of TK/GCV system for osteosarcoma MG-63 cell damage].
Osteosarcoma
[Suppression of osteosarcoma in vitro by coexpression of antisense VEGF165 cDNA and thymidine kinase gene]
Ovarian Neoplasms
Adenovirus mediated thymidine kinase gene therapy may enhance sensitivity of ovarian cancer cells to chemotherapeutic agents.
Ovarian Neoplasms
Adenovirus-mediated gene therapy of ovarian cancer in a mouse model.
Ovarian Neoplasms
Adenovirus-mediated thymidine kinase gene therapy and coxsackie adenovirus receptor expression in ovarian cancer cells.
Ovarian Neoplasms
Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.
Ovarian Neoplasms
Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up.
Ovarian Neoplasms
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.
Ovarian Neoplasms
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM.
Ovarian Neoplasms
Comparison of long-term survival of cytomegalovirus promotre versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer.
Ovarian Neoplasms
Delivery of herpes simplex thymidine kinase bystander effect by engineered human mesothelial cells for the treatment of ovarian cancer.
Ovarian Neoplasms
High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.
Ovarian Neoplasms
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Ovarian Neoplasms
Improvement of gene therapy for ovarian cancer by using acyclovir instead of ganciclovir in adenovirus mediated thymidine kinase gene therapy.
Ovarian Neoplasms
In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration.
Ovarian Neoplasms
Intraperitoneal adenovirus-mediated suicide gene therapy in combination with either topotecan or paclitaxel in nude mice with human ovarian cancer.
Ovarian Neoplasms
Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model.
Ovarian Neoplasms
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
Ovarian Neoplasms
Papers to appear in forthcoming issues
Ovarian Neoplasms
Persistent adenovirus-mediated thymidine kinase gene expression in ovarian cancer cells increases cell killing efficacy over time.
Ovarian Neoplasms
Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer.
Ovarian Neoplasms
Research on application value of combined detection of serum CA125, HE4 and TK1 in the diagnosis of ovarian cancer.
Ovarian Neoplasms
Serum thymidine kinase levels are elevated and exhibit diurnal variations in patients with advanced ovarian cancer.
Ovarian Neoplasms
Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications.
Ovarian Neoplasms
Suicide gene therapy of ovarian cancer: an experimental study in rats using retroviral-mediated transfer of herpes simplex virus thymidine kinase gene.
Ovarian Neoplasms
The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
Ovarian Neoplasms
The piggyback transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
Ovarian Neoplasms
Thymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment.
Ovarian Neoplasms
Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer.
Ovarian Neoplasms
[Animal experiment on gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration in vivo]
Ovarian Neoplasms
[Effect of the herpes simplex virus I-thymidine kinase gene-ganciclovir system on the transplant of human ovarian cancer on the omentum of nude mice]
Ovarian Neoplasms
[Effects of herpes simplex virus thymidine kinase gene transduction and prodrug on ovarian cancer cell]
Ovarian Neoplasms
[In vitro experimental study of gene therapy for ovarian cancer with thymidine kinase gene of herpes simplex virus mediated by a non-viral GE7 delivery system]
Ovarian Neoplasms
[Inhibitory effect of ganciclovir on the HSV1-tk positive subcutaneous tumors transplanted with human ovarian cancer in nude mice]
Ovarian Neoplasms
[Transfer of thymidine kinase gene of herpes simplex virus mediated by retrovirus vector into ovarian cancer cells]
Pancreatic Neoplasms
Effective ablation of pancreatic cancer cells in SCID mice using systemic adenoviral RIP-TK/GCV gene therapy.
Pancreatic Neoplasms
Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene.
Pancreatic Neoplasms
Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer.
Pancreatic Neoplasms
Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]FLT) in pancreatic cancer cell lines.
Pancreatic Neoplasms
Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Pancreatic Neoplasms
Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir.
Pancreatic Neoplasms
Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer.
Pancreatic Neoplasms
In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model.
Pancreatic Neoplasms
Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy.
Pancreatic Neoplasms
Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer.
Pancreatic Neoplasms
Retrovirus-mediated herpes simplex virus thymidine kinase gene transfer in pancreatic cancer cell lines: an incomplete antitumor effect.
Pancreatic Neoplasms
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: implications for gene therapy.
Pancreatic Neoplasms
Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors.
Pancreatic Neoplasms
Thymidine kinase 1 silencing retards proliferative activity of pancreatic cancer cell via E2F1-TK1-P21 axis.
Pancreatic Neoplasms
[Expression of the radio-inducible TK suicide gene controlled by Egr-1 promoter in pancreatic cancer cells: an in vitro experiment]
Pancreatic Neoplasms
[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others]
Papilloma
An expression vector inhibits gene expression in Xenopus embryos by antisense RNA.
Papilloma
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Papilloma
Recovery of a hybrid vector, derived from bovine papilloma virus DNA, pBR322 and the HSV tk gene, by bacterial transformation with extrachromosomal DNA from transfected rodent cells.
Paramyxoviridae Infections
Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity.
Paraproteinemias
Analysis of thymidine kinase serum levels by novel method DiviTum in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT.
Paraproteinemias
Plasma cell proliferation in monoclonal gammopathies: measurement using BU-1 antibody in flow cytometry and microscopy: comparison with serum thymidine kinase.
Paraproteinemias
Prognostic significance of serum immunoglobulin paraprotein in patients with chronic lymphocytic leukemia.
Paraproteinemias
Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
Paraproteinemias
Serum thymidine kinase in monoclonal gammopathies. A prospective study. The Cooperative Group for Study and Treatment of Multiple Myeloma.
Paraproteinemias
[Analysis of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma]
Parasitic Diseases
Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets.
Parathyroid Neoplasms
Purification and characterization of calcium-calmodulin kinase II from human parathyroid glands.
Peritoneal Neoplasms
Combined suicide and cytokine gene therapy for peritoneal carcinomatosis.
Peritoneal Neoplasms
HSV-1 thymidine kinase gene therapy for colorectal adenocarcinoma-derived peritoneal carcinomatosis.
Peritoneal Neoplasms
HSV-1 thymidine kinase gene therapy for peritoneal carcinomatosis.
Peritoneal Neoplasms
Similar efficiency of DNA-liposome complexes and retrovirus-producing cells for HSV-tk suicide gene therapy of peritoneal carcinomatosis.
Peritoneal Neoplasms
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
Peritonitis
Retrovirus-mediated in vivo gene therapy using the herpes simplex virus thymidine kinase gene against carcinomatous peritonitis.
Pheochromocytoma
Localization of cis-acting sequences in the latency-related promoter of bovine herpesvirus 1 which are regulated by neuronal cell type factors and immediate-early genes.
Photosensitivity Disorders
Photofrin II photosensitization is mutagenic at the tk locus in mouse L5178Y cells.
Pituitary Neoplasms
Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array.
Pituitary Neoplasms
Epstein-Barr virus-based vector improves the tumor cell killing effect of pituitary tumor in HVJ-liposome-mediated transcriptional targeting suicide gene therapy.
Pituitary Neoplasms
GENE THERAPY FOR THE TREATMENT OF PITUITARY TUMORS.
Pituitary Neoplasms
Gene therapy in the neuroendocrine system: its implementation in experimental models using viral vectors.
Pituitary Neoplasms
Neuroendocrinology of aging: the potential of gene therapy as an interventive strategy.
Pituitary Neoplasms
Okadaic acid, a protein phosphatase inhibitor, enhances transcription of a receptor gene containing sequence A of the human prolactin promoter.
Pituitary Neoplasms
Potential of gene therapy for the treatment of pituitary tumors.
Pituitary Neoplasms
Regulatory elements of the human proopiomelanocortin gene promoter.
Plague
A Thymidine Kinase recombinant protein-based ELISA for detecting antibodies to Duck Plague Virus.
Pleural Effusion
Thymidine kinase 1 concentration in pleural effusion is a diagnostic marker and survival predictor for malignant pleural effusion.
Pleural Effusion
Tumor markers in pleural effusions.
Pleural Effusion, Malignant
Thymidine kinase 1 concentration in pleural effusion is a diagnostic marker and survival predictor for malignant pleural effusion.
Pneumoperitoneum
Effects of CO2 pneumoperitoneum on the expression of thymidine kinase 1 and Ki67 in colorectal carcinoma cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical significance of thymidine kinase in Egyptian children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lymphocyte thymidine kinase and treatment response in acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The role of p16 in the E2F-dependent thymidine kinase regulation.
Prolactinoma
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
Prolactinoma
Potential of gene therapy for the treatment of pituitary tumors.
Prostatic Hyperplasia
In vivo characterization of a prostate-specific antigen promoter-based suicide gene therapy for the treatment of benign prostatic hyperplasia.
Prostatic Hyperplasia
Serum thymidine kinase 1 is associated with Gleason score of patients with prostate carcinoma.
Prostatic Neoplasms
20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines.
Prostatic Neoplasms
A Pilot Study of Quality of Life of Patients with Hormone-refractory Prostate Cancer after Gene Therapy.
Prostatic Neoplasms
Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer.
Prostatic Neoplasms
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Prostatic Neoplasms
Altered expression of connexin-43 and impaired capacity of gap junctional intercellular communication in prostate cancer cells.
Prostatic Neoplasms
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker.
Prostatic Neoplasms
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Prostatic Neoplasms
Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth.
Prostatic Neoplasms
Comparison of bioactivities of 5-Fluoro, 5-Iodo, 5-Iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells.
Prostatic Neoplasms
Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer.
Prostatic Neoplasms
Cooperative therapeutic effects of herpes simplex virus thymidine kinase gene/ganciclovir system and chemotherapeutic agents on prostate cancer in vitro.
Prostatic Neoplasms
Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells.
Prostatic Neoplasms
Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.
Prostatic Neoplasms
Gene therapy for castration-resistant prostate cancer cells using JC polyomavirus-like particles packaged with a PSA promoter driven-suicide gene.
Prostatic Neoplasms
Gene therapy for prostate cancer: toxicological profile of four HSV-tk transducing adenoviral vectors regulated by different promoters.
Prostatic Neoplasms
Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques.
Prostatic Neoplasms
Identification of glucocorticoid-responsive elements that control transcription of rat glutamine synthetase.
Prostatic Neoplasms
Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.
Prostatic Neoplasms
Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer.
Prostatic Neoplasms
Low p16(INK4a) Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone.
Prostatic Neoplasms
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Prostatic Neoplasms
Micro-PET/CT monitoring of herpes thymidine kinase suicide gene therapy in a prostate cancer xenograft: the advantage of a cell-specific transcriptional targeting approach.
Prostatic Neoplasms
Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants.
Prostatic Neoplasms
Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer.
Prostatic Neoplasms
Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer.
Prostatic Neoplasms
Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer.
Prostatic Neoplasms
Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer--a preliminary report.
Prostatic Neoplasms
Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University.
Prostatic Neoplasms
Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models.
Prostatic Neoplasms
Protein Delivery of Thymidylate Kinase Mediated by Tumor-Specific Antibody-Precoated Microvesicles.
Prostatic Neoplasms
Suicide gene therapy for prostate cancer using a replication-deficient adenovirus containing the herpesvirus thymidine kinase gene.
Prostatic Neoplasms
Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer.
Prostatic Neoplasms
Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy.
Prostatic Neoplasms
Suppression of bone metastatic castration-resistant prostate cancer cell growth by a suicide gene delivered by JC polyomavirus-like particles.
Prostatic Neoplasms
Targeted expression of E. coli purine nucleoside phosphorylase and Fludara for prostate cancer therapy.
Prostatic Neoplasms
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
Prostatic Neoplasms
Thymidine Kinase Gene Modified Bone Marrow Mesenchymal Stem Cells as Vehicles for Anti-tumor Therapy.
Prostatic Neoplasms
Thymidine Kinase-1 as Additional Diagnostic Marker of Prostate Cancer.
Prostatic Neoplasms
Treatment efficiency of a suicide gene therapy using prostate-specific membrane antigen promoter/enhancer in a castrated mouse model of prostate cancer.
Prostatic Neoplasms
Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters.
Pseudolymphoma
Pyrimidine and purine activities in non-Hodgkin's lymphoma. Correlation with histological status and survival.
Pseudorabies
A comparative study of pseudorabies virus (PRV) strains with defects in thymidine kinase and glycoprotein genes.
Pseudorabies
A study of two mutant strains of pseudorabies virus (PRV) unable to express thymidine kinase (TK) function.
Pseudorabies
A vaccine strain of pseudorabies virus with deletions in the thymidine kinase and glycoprotein X genes.
Pseudorabies
Attenuated properties of thymidine kinase-negative deletion mutant of pseudorabies virus.
Pseudorabies
Characterization of Japanese isolates of Aujeszky's disease virus by restriction endonuclease cleavage patterns, virulence in mice and thymidine kinase activity.
Pseudorabies
Characterization of promoters integrated in the genome of bovine herpesvirus-1 (BHV-1).
Pseudorabies
Characterization of virulent and attenuated strains of pseudorabies virus for thymidine kinase activity, virulence and restriction patterns.
Pseudorabies
Construction of bovine herpesvirus-1 (BHV-1) recombinants which express pseudorabies virus (PRV) glycoproteins gB, gC, gD, and gE.
Pseudorabies
Diagnostic compatibility of a thymidine kinase, inverted repeat, gI, and gpX modified live gene-deleted PRV vaccine with three differential ELISAs.
Pseudorabies
Efficacy of a pseudorabies virus vaccine based on deletion mutant strain 783 that does not express thymidine kinase and glycoprotein I.
Pseudorabies
Evaluation of swinepox virus as a vaccine vector in pigs using an Aujeszky's disease (pseudorabies) virus gene insert coding for glycoproteins gp50 and gp63.
Pseudorabies
Evaluation of the safety and efficacy of a thymidine kinase, inverted repeat, gI, and gpX gene-deleted pseudorabies vaccine.
Pseudorabies
Experimental infection of pigs with a thymidine kinase negative strain of pseudorabies virus.
Pseudorabies
Genetic basis of the neurovirulence of pseudorabies virus.
Pseudorabies
Genetic recombination of pseudorabies virus: evidence that homologous recombination between insert sequences is less frequent than between autologous sequences.
Pseudorabies
Genotypic screening of pseudorabies virus strains for thymidine kinase deletions by use of the polymerase chain reaction.
Pseudorabies
Growth properties and vaccine efficacy of recombinant pseudorabies virus defective in glycoprotein E and thymidine kinase genes.
Pseudorabies
In vivo recombination of pseudorabies virus strains in mice.
Pseudorabies
Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity.
Pseudorabies
Inactivation of the thymidine kinase gene of a gI deletion mutant of pseudorabies virus generates a safe but still highly immunogenic vaccine strain.
Pseudorabies
Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus.
Pseudorabies
Influence of vaccination route on the efficacy of Aujeszky's disease deletion-mutant vaccine.
Pseudorabies
Is recombination of PRV vaccine strains a real problem?
Pseudorabies
Lack of stereospecificity of suid pseudorabies virus thymidine kinase.
Pseudorabies
Loss of pseudorabies virus thymidine kinase activity due to a single base mutation and amino acid substitution.
Pseudorabies
Mitochondrial and herpesvirus-specific deoxypyrimidine kinases.
Pseudorabies
Molecular analysis of pseudorabies viral vaccines and their rapid differentiation from wild-type isolates using DNA-amplified glycoprotein I and thymidine kinase gene segment polymorphisms.
Pseudorabies
Multiple sets of adjacent mu E1 and oct-1 binding sites upstream of the pseudorabies virus immediate-early gene promoter.
Pseudorabies
Necrotic oophoritis in gilts associated with experimental inoculation of a viral gene-deletion mutant pseudorabies vaccine.
Pseudorabies
Novel strategy for generation and titration of recombinant adeno-associated virus vectors.
Pseudorabies
Replication of virulent and attenuated strains of Aujeszky's disease virus in swine alveolar macrophages.
Pseudorabies
Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection.
Pseudorabies
Safety of an Aujeszky's disease vaccine based on deletion mutant strain 783 which does not express thymidine kinase and glycoprotein I.
Pseudorabies
Second-generation pseudorabies virus vaccine with deletions in thymidine kinase and glycoprotein genes.
Pseudorabies
Some characteristics of four attenuated vaccine virus strains and a virulent strain of Aujeszky's disease virus.
Pseudorabies
The response of pigs inoculated with a thymidine kinase-negative (TK-) pseudorabies virus to challenge infection with virulent virus.
Pseudorabies
The role of pseudorabies virus thymidine kinase expression in trigeminal ganglion infection.
Pseudorabies
Vaccination of mice and swine with a pseudorabies virus mutant lacking thymidine kinase activity.
Pseudorabies
Vaccination of swine with thymidine kinase-deficient mutants of pseudorabies virus.
Pseudorabies
Virus reactivation in pigs latently infected with a thymidine kinase negative vaccine strain of pseudorabies virus.
Pseudorabies
[Thymidine kinase activity of virulent and vaccinal strains of Aujeszky's disease virus]
Pyelonephritis
Chronic pyelonephritis presenting as multiple tumor-like renal lesions.
Pyometra
Elevation of serum thymidine kinase 1 in a bacterial infection: canine pyometra.
Rabies
Development of a recombinant vaccinia-rabies vaccine for oral vaccination of foxes against rabies.
Rabies
Raccoon poxvirus live recombinant feline panleukopenia virus VP2 and rabies virus glycoprotein bivalent vaccine.
Rabies
The development and use of a vaccinia-rabies recombinant oral vaccine for the control of wildlife rabies; a link between Jenner and Pasteur.
Renal Insufficiency
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.
Respiratory Insufficiency
Preferent Diaphragmatic Involvement in TK2 Deficiency: An Autopsy Case Study.
Respiratory Insufficiency
Successful pregnancy and cesarean delivery via noninvasive ventilation in mitochondrial myopathy.
Respiratory Tract Infections
In vivo function of the Murid Herpesvirus-4 ribonucleotide reductase small subunit.
Retinal Necrosis Syndrome, Acute
Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome.
Retinal Necrosis Syndrome, Acute
[Expression of the varicella zoster virus thymidine kinase and cytokines in patients with acute retinal necrosis syndrome]
Retinoblastoma
A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene.
Retinoblastoma
Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma.
Retinoblastoma
Adventitial gene transfer to arterial wall.
Retinoblastoma
An experimental application of gene therapy for human retinoblastoma.
Retinoblastoma
Cardiovascular gene therapy.
Retinoblastoma
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Retinoblastoma
Failure of RB1 to reverse the malignant phenotype of human tumor cell lines.
Retinoblastoma
Gene and other biological therapies for vascular diseases.
Retinoblastoma
Gene therapy for ischemic heart disease.
Retinoblastoma
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Retinoblastoma
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.
Retinoblastoma
p600, a unique protein required for membrane morphogenesis and cell survival.
Retinoblastoma
Pharmacokinetics, safety, activity, and biomarker analysis of palbociclib plus letrozole as first-line treatment for ER+/HER2- advanced breast cancer in Chinese women.
Retinoblastoma
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.
Retinoblastoma
Suicide gene therapy for treatment of retinoblastoma in a murine model.
Retinoblastoma
The role of p16 in the E2F-dependent thymidine kinase regulation.
Retinoblastoma
Vascular gene transfer for the treatment of restenosis and atherosclerosis.
Retinoblastoma
Vascular gene transfer.
Retinoblastoma
[Studies on thymidine kinase gene (TK) and GCV system for treatment of human retinoblastoma (RB)]
Retinoblastoma
[The status of gene therapy in cardiovascular medicine]
Retroviridae Infections
Suicide Gene Therapy Mediated with Exosomes Produced by Mesenchymal Stem/Stromal Cells Stably Transduced with HSV Thymidine Kinase.
Rhabdomyolysis
Recurrent rhabdomyolysis and exercise intolerance: A new phenotype of late-onset thymidine kinase 2 deficiency.
Rhabdomyosarcoma
Suicide gene therapy of rhabdomyosarcoma.
Rift Valley Fever
Protection of Cattle Elicited Using a Bivalent Lumpy Skin Disease Virus-Vectored Recombinant Rift Valley Fever Vaccine.
Rinderpest
Immunization with a vaccinia recombinant expressing the F protein protects rabbits from challenge with a lethal dose of rinderpest virus.
Rinderpest
Recombinant capripoxvirus expressing the hemagglutinin protein gene of rinderpest virus: protection of cattle against rinderpest and lumpy skin disease viruses.
Salivary Gland Neoplasms
Combination gene therapy for salivary gland cancer.
Sarcoidosis
Increased serum thymidine kinase activity in acute sarcoidosis.
Sarcoma
3'-deoxy-3'-[(18) F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: A pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response.
Sarcoma
Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo.
Sarcoma
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Sarcoma
Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences.
Sarcoma
Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1.
Sarcoma
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Sarcoma
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Sarcoma
Efficient expression of cloned complementary DNAs for secretory proteins after injection into Xenopus oocytes.
Sarcoma
Enhanced transformation by a simian virus 40 recombinant virus containing a Harvey murine sarcoma virus long terminal repeat.
Sarcoma
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Sarcoma
In vivo imaging of cell proliferation in meningioma using 3'-deoxy-3'-[18F]fluorothymidine PET/MRI.
Sarcoma
Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.
Sarcoma
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.
Sarcoma
Multiple transduction as a means of preserving ganciclovir chemosensitivity in sarcoma cells carrying retrovirally transduced herpes thymidine kinase genes.
Sarcoma 180
Mode of action of the bioreductive alkylating agent, 2,3-bis(chloromethyl)-1,4-naphthoquinone.
Sarcoma 180
Mouse ascites sarcoma 180 thymidylate kinase. General properties, kinetic analysis, and inhibition studies.
Sarcoma, Avian
A comparison of transcriptional regulatory element activities in transformed and non-transformed rat anterior pituitary cells.
Sarcoma, Avian
Activation of an endogenous retrovirus enhancer by insertion into a heterologous context.
Sarcoma, Avian
Adenovirus-mediated gene therapy of experimental gliomas.
Sarcoma, Avian
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
Sarcoma, Avian
Allium sativum potentiates suicide gene therapy for murine transitional cell carcinoma.
Sarcoma, Avian
Antiviral activity of herpes simplex virus vectors expressing murine alpha 1-interferon.
Sarcoma, Avian
Avian sarcoma virus transformed hamster cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity.
Sarcoma, Avian
Characterization of the promoter of human pulmonary surfactant protein B gene.
Sarcoma, Avian
Comparison of long-term survival of cytomegalovirus promotre versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer.
Sarcoma, Avian
Construction of a recombinant adeno-associated virus (rAAV) vector expressing murine interleukin-12 (IL-12).
Sarcoma, Avian
Demethylation and expression of methylated plasmid DNA stably transfected into HeLa cells.
Sarcoma, Avian
Differential transient and long-term expression of DNA sequences introduced into T-lymphocyte lines.
Sarcoma, Avian
Efficiency of introns from various origins in fish cells.
Sarcoma, Avian
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.
Sarcoma, Avian
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
Sarcoma, Avian
Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase.
Sarcoma, Avian
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Sarcoma, Avian
Inhibition of viral and cellular promoters by human wild-type p53.
Sarcoma, Avian
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.
Sarcoma, Avian
Persistent adenovirus-mediated thymidine kinase gene expression in ovarian cancer cells increases cell killing efficacy over time.
Sarcoma, Avian
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Sarcoma, Avian
Proximal upstream flanking sequences direct calcium regulation of the rat prolactin gene.
Sarcoma, Avian
Rearrangements of microinjected recombinant DNA in the genome of transgenic mice.
Sarcoma, Avian
Structure and inducible regulation of the human c-erb B2/neu promoter.
Sarcoma, Avian
TEF-1 transrepression in BeWo cells is mediated through interactions with the TATA-binding protein, TBP.
Sarcoma, Avian
The effects of transcriptional regulatory sequences introduced into a retroviral genome.
Sarcoma, Avian
The human chorionic somatomammotropin gene enhancer is composed of multiple DNA elements that are homologous to several SV40 enhansons.
Sarcoma, Avian
The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming.
Sarcoma, Avian
[Animal experiment on gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration in vivo]
Sarcoma, Ewing
Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer.
Sarcoma, Yoshida
DNA synthesis in tumor-bearing rats.
Sarcoma, Yoshida
DNA synthesis in tumor-bearing rats: purification of liver thymidine kinase stimulating factor from Yoshida sarcoma.
Sarcoma, Yoshida
Effect of RN-ase treatment on Yoshida sarcoma thymidine kinase.
Sarcoma, Yoshida
Intracellular distribution of various enzymes concerned with DNA synthesis from normal and regenerating rat liver, and Yoshida sarcoma.
Sarcoma, Yoshida
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Severe Combined Immunodeficiency
Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.
Small Cell Lung Carcinoma
Clinical and serologic markers of stage and prognosis in small cell lung cancer. A multivariate analysis.
Small Cell Lung Carcinoma
Correlation between serum tumor marker levels and tumor proliferation in small cell lung cancer.
Small Cell Lung Carcinoma
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Small Cell Lung Carcinoma
Neuron-specific enolase and thymidine kinase as an aid to the diagnosis and treatment monitoring of small cell lung cancer.
Small Cell Lung Carcinoma
Prognostic value of serum thymidine kinase, tissue polypeptide antigen and neuron specific enolase in patients with small cell lung cancer.
Small Cell Lung Carcinoma
Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer.
Small Cell Lung Carcinoma
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Smallpox
Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox - Part II.
Smallpox
Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox.
Smallpox
Enhancing the Protective Immune Response to Administration of a LIVP-GFP Live Attenuated Vaccinia Virus to Mice.
Smallpox
First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells.
Smallpox
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.
Smallpox
Nucleotide sequence of the thymidine kinase gene region of monkeypox and variola viruses.
Smallpox
Preventing the return of smallpox: molecular modeling studies on thymidylate kinase from Variola virus.
Smallpox
Quaternary structure of vaccinia virus thymidine kinase.
Spinal Cord Injuries
Impact of Depletion of Microglia/Macrophages on Regeneration after Spinal Cord Injury.
Squamous Cell Carcinoma of Head and Neck
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Squamous Cell Carcinoma of Head and Neck
Synthetic radiation-inducible promoters mediated HSV-TK/GCV gene therapy in the treatment of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Thymidine kinase activity in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
Starvation
Activity of thymidine kinase during the cell cycle in Tetrahymena pyriformis.
Starvation
EGF-like peptide-enhanced cell movement in Dictyostelium is mediated by protein kinases and the activity of several cytoskeletal proteins.
Starvation
Ileal hyperplastic response to starvation in the rat.
Starvation
Regulation of gastric mucosal DNA synthesis during fasting and refeeding in rats.
Starvation
Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.
Starvation
Thymidine kinase in mouse liver: variations in soluble and mitochondrial-associated activity that are dependent on age, regeneration, starvation, and treatment with actinomycin D and puromycin.
Stomach Neoplasms
Activities of thymidylate synthetase and thymidine kinase in gastric cancer.
Stomach Neoplasms
Adenovirus-mediated gene therapy of gastric carcinoma using cancer-specific gene expression in vivo.
Stomach Neoplasms
Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.
Stomach Neoplasms
An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice.
Stomach Neoplasms
Changes in serum thymidine kinase 1 levels during chemotherapy correlate with objective response in patients with advanced gastric cancer.
Stomach Neoplasms
Do there exist synergistic antitumor effects by coexpression of herpes simplex virus thymidine kinase with cytokine genes on human gastric cancer cell line SGC7901?
Stomach Neoplasms
Heat-directed suicide gene therapy mediated by heat shock protein promoter for gastric cancer.
Stomach Neoplasms
Human colorectal malignancy and oral UFT.
Stomach Neoplasms
The half-life of thymidine kinase 1 in serum measured by ECL dot blot: a potential marker for monitoring the response to surgery of patients with gastric cancer.
Stomach Neoplasms
[The dynamics of the enzymatic activity of DNA metabolism during the treatment of stomach cancer patients]
Stomach Neoplasms
[Thymidine kinase and thymidylate synthetase activities in human gastric cancer]
Stomach Ulcer
[Age-related characteristics of thymidine metabolism in healthy subjects and in patients with stomach ulcer and cancer]
Superinfection
Characterization of Epstein-Barr virus-related thymidine kinase induced in nonproducer cells by superinfection or chemical treatment.
Superinfection
Clonal analysis of early and late stages of erythroleukemia induced by molecular clones of integrated spleen focus-forming virus.
Superinfection
Enhancement of herpes simplex virus type 2 (HSV-2) DNA synthesis in infected cells that constitutively express the BglII-N region of the HSV-2 genome.
Superinfection
Epstein-Barr virus-associated thymidine kinase.
Superinfection
HSV-1 thymidine kinase negative vaccine: pathogenicity, protection, and perils.
Superinfection
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1.
Superinfection
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.
Superinfection
Thymidine kinase activity of biochemically transformed mouse cells after superinfection by thymidine kinase-negative, temperature-sensitive, herpes simplex virus mutants.
Superinfection
Thymidine kinase deletion mutants of herpes simplex virus type 1.
Teratocarcinoma
Cotransfer and phenotypic stabilisation of syntenic and asyntenic mink genes into mouse cells by chromosome-mediated gene transfer.
Teratocarcinoma
DNA-transformed murine teratocarcinoma cells: regulation of expression of simian virus 40 tumor antigen in stem versus differentiated cells.
Teratocarcinoma
Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells.
Teratocarcinoma
Tissue preference and differentiation of malignant rat x mouse hybrid cells in chimaeric mouse fetuses.
Teratoma
A scalable approach to prevent teratoma formation of human embryonic stem cells.
Teratoma
Embryonic Stem Cells Modulate the Cancer-Permissive Microenvironment of Human Uveal Melanoma.
Teratoma
Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy.
Thoracic Neoplasms
Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.
Thrombocytopenia
Serum Thymidine Kinase 1, Canine-C-Reactive Protein, Haptoglobin, and Vitamin D Concentrations in Dogs with Immune-Mediated Hemolytic Anemia, Thrombocytopenia, and Polyarthropathy.
Thrombocytopenia
Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.
Thrombocytopenia
[Mantle cell lymphoma as a diagnostic and therapeutic problem]
thymidine kinase deficiency
Abilities of wild-type and thymidine kinase-deficient Friend mouse erythroleukemia cells to undergo unscheduled DNA synthesis following mutagen treatment.
thymidine kinase deficiency
AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone.
thymidine kinase deficiency
Assignment of TK1 encoding thymidine kinase to Syrian hamster chromosome 9 by microcell-mediated chromosome transfer.
thymidine kinase deficiency
Azacytidine induces reversion of thymidine kinase deficiency in Friend erythroleukemia cells.
thymidine kinase deficiency
Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency.
thymidine kinase deficiency
Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence.
thymidine kinase deficiency
Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances.
thymidine kinase deficiency
Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency.
thymidine kinase deficiency
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.
thymidine kinase deficiency
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
thymidine kinase deficiency
Effects of deoxycytidine and thymidine kinase deficiency on substrate cycles between deoxyribonucleosides and their 5'-phosphates.
thymidine kinase deficiency
Evidence for linear response for the induction of mutations in human cells by x-ray exposures below 10 rads.
thymidine kinase deficiency
Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53.
thymidine kinase deficiency
Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle.
thymidine kinase deficiency
Herpes simplex virus resistance to acyclovir: clinical relevance.
thymidine kinase deficiency
Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.
thymidine kinase deficiency
Induction of thymidine kinase in enzyme-deficient Chinese hamster cells.
thymidine kinase deficiency
Late-onset thymidine kinase 2 deficiency: a review of 18 cases.
thymidine kinase deficiency
Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency.
thymidine kinase deficiency
Mutagen sensitivity in thymidine kinase- and methyltransferase-deficient human lymphoblastoid cells.
thymidine kinase deficiency
Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus.
thymidine kinase deficiency
Phenotypic evolution of cells resistant to bromodeoxyuridine.
thymidine kinase deficiency
Recurrent rhabdomyolysis and exercise intolerance: A new phenotype of late-onset thymidine kinase 2 deficiency.
thymidine kinase deficiency
Regulatory environment for novel therapeutic development in mitochondrial diseases.
thymidine kinase deficiency
Retrospective natural history of thymidine kinase 2 deficiency.
thymidine kinase deficiency
Successful pregnancy and cesarean delivery via noninvasive ventilation in mitochondrial myopathy.
thymidine kinase deficiency
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
thymidine kinase deficiency
Thymidine kinase 2 and alanyl-tRNA synthetase 2 deficiencies cause lethal mitochondrial cardiomyopathy: case reports and review of the literature.
thymidine kinase deficiency
Transfer of nonselectable genes into mouse teratocarcinoma cells and transcription of the transferred human beta-globin gene.
thymidine kinase deficiency
Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.
Thymoma
Fluctuation of antigen binding activity during the cell cycle in the synchronized population of the murine T hybridoma cell line.
Thyroid Cancer, Papillary
Increased expression of mRNA specific for thymidine kinase, deoxycytidine kinase or thymidine phosphorylase in human papillary thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.
Thyroid Diseases
Expression of genes for certain enzymes of pyrimidine and purine salvage pathway in peripheral blood leukocytes collected from patients with Graves' or Hashimoto's disease.
Thyroid Diseases
[Thymidine kinase and its isozyme activities in human thyroid diseases]
Thyroid Neoplasms
A tandemly repeated thyroglobulin core promoter has potential to enhance efficacy for tissue-specific gene therapy for thyroid carcinomas.
Thyroid Neoplasms
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Thyroid Neoplasms
Adenoviral-mediated gene therapy for thyroid carcinoma using thymidine kinase controlled by thyroglobulin promoter demonstrates high specificity and low toxicity.
Thyroid Neoplasms
Adenovirus HSV-TK construct with thyroid-specific promoter: enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the camp pathway.
Thyroid Neoplasms
An adenoviral vector expressing functional heterogeneous proteins herpes simplex viral thymidine kinase and human interleukin-2 has enhanced in vivo antitumor activity against medullary thyroid carcinoma.
Thyroid Neoplasms
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Thyroid Neoplasms
Construction of gene therapy vectors targeting thyroid cells: enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the cyclic adenosine 3',5'-monophosphate pathway and demonstration of activity in follicular and anaplastic thyroid carcinoma cells.
Thyroid Neoplasms
Gene therapy of established medullary thyroid carcinoma with herpes simplex viral thymidine kinase in a rat tumor model: relationship of bystander effect and antitumor efficacy.
Thyroid Neoplasms
Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.
Thyroid Neoplasms
Knockdown of Thymidine Kinase 1 Suppresses Cell Proliferation, Invasion, Migration, and Epithelial-Mesenchymal Transition in Thyroid Carcinoma Cells.
Thyroid Neoplasms
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Thyroid Neoplasms
Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo.
Thyroid Neoplasms
Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.
Thyroid Neoplasms
Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors.
Thyroid Neoplasms
Viral mediated gene therapy for the management of metastatic thyroid carcinoma.
Tongue Neoplasms
DNA-liposome complexes transduction of herpes simplex virus thymidine kinase renders human tongue cancer cell line sensitive to ganciclovir in vitro.
Tuberculosis
1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.
Tuberculosis
2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn).
Tuberculosis
Activation of NF-kappaB in Mycobacterium tuberculosis- induced interleukin-2 receptor expression in mononuclear phagocytes.
Tuberculosis
Anti-mycobacterial activity of thymine derivatives bearing boron clusters.
Tuberculosis
Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals.
Tuberculosis
Cryophotolysis of caged compounds: a technique for trapping intermediate states in protein crystals.
Tuberculosis
Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis.
Tuberculosis
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.
Tuberculosis
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
Tuberculosis
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Tuberculosis
Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.
Tuberculosis
Immuno-diagnosis of Mycobacterium tuberculosis in sputum, and reduction of timelines for its positive cultures to within 3 h by pathogen-specific thymidylate kinase expression assays.
Tuberculosis
In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis.
Tuberculosis
Mycobacterium tuberculosis thymidylate kinase antigen assays for designating incipient, high-risk latent M.tb infection.
Tuberculosis
Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.
Tuberculosis
Protein kinases as antituberculosis targets: The case of thymidylate kinases.
Tuberculosis
Sero-diagnosis of Active Mycobacterium tuberculosis Disease among HIV Co-infected Persons using Thymidylate Kinase based Antigen and Antibody Capture Enzyme Immuno-Assays.
Tuberculosis
Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors.
Tuberculosis
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
Tuberculosis
Structure-aided design of inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Tuberculosis
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.
Tuberculosis
Synthesis and antiviral evaluation of ?-l-2'-deoxythreofuranosyl nucleosides.
Tuberculosis
Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.
Tuberculosis
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Tuberculosis
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Tuberculosis
Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents.
Tuberculosis
The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.
Tuberculosis
The thymidylate kinase genes from Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus confer 3'-azido-3'-deoxythymidine resistance to Escherichia coli.
Tuberculosis
Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays.
Tuberculosis
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Tuberculosis
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.
Tuberculosis
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
Tumor Virus Infections
Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus.
Tumor Virus Infections
Thymidine kinase activity in human amnion cell cultures infected with Shope fibroma virus.
Urinary Bladder Neoplasms
Adenovirus-mediated suicide gene therapy for bladder cancer: comparison of the cytomegalovirus- and Rous sarcoma virus-promoter.
Urinary Bladder Neoplasms
Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models.
Urinary Bladder Neoplasms
Basis for the differential modulation of the uptake of 5-iododeoxyuridine by 5'-aminothymidine among various cell types.
Urinary Bladder Neoplasms
Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer.
Urinary Bladder Neoplasms
Combination of adenovirus-mediated thymidine kinase gene therapy with cytotoxic chemotherapy in bladder cancer in vitro.
Urinary Bladder Neoplasms
Cytotoxic activity of gemcitabine in cultured cell lines derived from histologically different types of bladder cancer: Role of thymidine kinase 2.
Urinary Bladder Neoplasms
Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
Urinary Bladder Neoplasms
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
Urinary Bladder Neoplasms
Massive apoptotic cell death in chemically induced rat urinary bladder carcinomas following in situ HSVtk electrogene transfer.
Urinary Bladder Neoplasms
Modulation of IdUrd-DNA incorporation and radiosensitization in human bladder carcinoma cells.
Urinary Bladder Neoplasms
Modulation of the feedback regulation of thymidine kinase activity by pH in 647V cells.
Urinary Bladder Neoplasms
Muscle-invasive bladder cancer is characterized by overexpression of thymidine kinase 1.
Urinary Bladder Neoplasms
Preferential stimulation of iododeoxyuridine phosphorylation by 5'-aminothymidine in human bladder cancer cells in vitro.
Urinary Bladder Neoplasms
[Studies on herpes simplex virus thymidine kinase gene and GCV system for treatment of human bladder carcinoma]
Uterine Cervical Neoplasms
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Uterine Cervical Neoplasms
High-level transgene expression mediated by the piggyBac transposon enhances transgenic therapeutic effects in cervical cancer xenografts.
Vaccinia
5-Iodo-2-deoxyuridine resistance of vaccinia viruses in cells endowed with thymidine kinase activity.
Vaccinia
A cancer-favoring oncolytic vaccinia virus shows enhanced suppression of stem-cell like colon cancer.
Vaccinia
A new oncolytic Vacciniavirus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery.
Vaccinia
A new recombinant vaccinia with targeted deletion of three viral genes: its safety and efficacy as an oncolytic virus.
Vaccinia
A PCR-based method for manipulation of the vaccinia virus genome that eliminates the need for cloning.
Vaccinia
A recombinant vaccinia virus expressing hepatitis A virus structural polypeptides: characterization and demonstration of protective immunogenicity.
Vaccinia
A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA).
Vaccinia
A recombinant vaccinia virus expressing the major capsid protein of Simian rotavirus-induced anti-rotavirus antibodies.
Vaccinia
A single amino acid substitution abolishes feedback inhibition of vaccinia virus thymidine kinase.
Vaccinia
A vaccinia virus double recombinant expressing the F and H genes of rinderpest virus protects cattle against rinderpest and causes no pock lesions.
Vaccinia
Accurate mass precursor ion data and tandem mass spectrometry identify a class I human leukocyte antigen A*0201-presented peptide originating from vaccinia virus.
Vaccinia
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Vaccinia
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Vaccinia
Addition of the MSA1 signal and anchor sequences to the malaria merozoite surface antigen 1 C-terminal region enhances immunogenicity when expressed by recombinant vaccinia virus.
Vaccinia
An oncolytic vaccinia virus armed with anti-human-PD-1 antibody and anti-human-4-1BB antibody double genes for cancer-targeted therapy.
Vaccinia
An Oncolytic Vaccinia Virus Armed with GM-CSF and IL-24 Double Genes for Cancer Targeted Therapy.
Vaccinia
Analysis of canine herpesvirus gB, gC and gD expressed by a recombinant vaccinia virus.
Vaccinia
Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models.
Vaccinia
Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers.
Vaccinia
Araçatuba virus: a vaccinialike virus associated with infection in humans and cattle.
Vaccinia
Association of non-viral proteins with recombinant vaccinia virus virions.
Vaccinia
Attenuation of Vaccinia Virus.
Vaccinia
Belo Horizonte virus: a vaccinia-like virus lacking the A-type inclusion body gene isolated from infected mice.
Vaccinia
Biological characterization of recombinant vaccinia viruses in mice infected by the respiratory route.
Vaccinia
Biophysical characterization of vaccinia virus thymidine kinase substrate utilization.
Vaccinia
Cell-free synthesis of enzymatically active vaccinia virus thymidine kinase.
Vaccinia
Characterization of a binding factor that interacts with the sequences upstream of the vaccinia virus thymidine kinase gene.
Vaccinia
Characterization of a vaccinia-like virus isolated in a Brazilian forest.
Vaccinia
Characterization of vaccinia virus early promoters and evaluation of their informational content.
Vaccinia
Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene.
Vaccinia
Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice.
Vaccinia
Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates.
Vaccinia
Conserved sequences near the early transcription start sites of vaccinia virus.
Vaccinia
Construction and characterization of vaccinia direct ligation vectors.
Vaccinia
Construction of a recombinant vaccinia virus expressing the Lassa virus glycoprotein gene and protection of guinea pigs from a lethal Lassa virus infection.
Vaccinia
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Vaccinia
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.
Vaccinia
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. 1982.
Vaccinia
Construction of recombinant swinepox viruses and expression of the classical swine fever virus E2 protein.
Vaccinia
Construction of recombinant vaccinia virus expressing GM-CSF and its use as tumor vaccine.
Vaccinia
Construction of recombinant vaccinia virus strains using single-stranded DNA insertion vectors.
Vaccinia
Construction of recombinant vaccinia virus: cloning into the thymidine kinase locus.
Vaccinia
Construction of vaccinia virus recombinants expressing several measles virus proteins and analysis of their efficacy in vaccination of mice.
Vaccinia
Control of expression of the vaccinia virus thymidine kinase gene.
Vaccinia
Control of thymidine kinase synthesis in IHD vaccinia virus-infected thymidine kinase-deficient LM cells.
Vaccinia
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy.
Vaccinia
Deletion of fowlpox virus homologues of vaccinia virus genes between the 3 beta-hydroxysteroid dehydrogenase (A44L) and DNA ligase (A50R) genes.
Vaccinia
Delineation of the viral products of recombination in vaccinia virus-infected cells.
Vaccinia
Determination of the promoter region of an early vaccinia virus gene encoding thymidine kinase.
Vaccinia
Development of a recombinant vaccinia-rabies vaccine for oral vaccination of foxes against rabies.
Vaccinia
Development of a replication-selective, oncolytic poxvirus for the treatment of human cancers.
Vaccinia
Dominant host range selection of vaccinia recombinants by rescue of an essential gene.
Vaccinia
Dominant negative selection of vaccinia virus using a thymidine kinase/thymidylate kinase fusion gene and the prodrug azidothymidine.
Vaccinia
Effect of in vitro mutations in a vaccinia virus early promoter region monitored by herpes simplex virus thymidine kinase expression in recombinant vaccinia virus.
Vaccinia
Effect of interferon on the dynamics of H3-thymidine incorporation and thymidine kinase induction in chick fibroblast cultures infected with vaccinia virus.
Vaccinia
Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase.
Vaccinia
Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase.
Vaccinia
Engineering of double recombinant vaccinia virus with enhanced oncolytic potential for solid tumor virotherapy.
Vaccinia
Evaluation of swinepox virus as a vaccine vector in pigs using an Aujeszky's disease (pseudorabies) virus gene insert coding for glycoproteins gp50 and gp63.
Vaccinia
Evaluation of the thymidine kinase (tk) locus as an insertion site in the highly attenuated vaccinia MVA strain.
Vaccinia
Evaluation of Tumor Specificity and Immunity of Thymidine Kinase-Deleted Vaccinia Virus Guang9 Strain.
Vaccinia
Evidence for an "early early" vaccinia virus-induced protein which causes a density change of infected L-M cells.
Vaccinia
Evolutionary cancer-favoring engineered vaccinia virus for metastatic hepatocellular carcinoma.
Vaccinia
Expression and characterization of the thymidine kinase gene of African swine fever virus.
Vaccinia
Expression and regulation of the vaccinia virus thymidine kinase gene in non-permissive cells.
Vaccinia
Expression and single-step purification of enzymatically active vaccinia virus thymidine kinase containing an engineered oligohistidine domain by immobilized metal affinity chromatography.
Vaccinia
Expression of authentic vaccinia virus-specific and inserted viral and cellular genes under control of an early vaccinia virus promoter is regulated post-transcriptionally in interferon-treated chick embryo fibroblasts.
Vaccinia
Expression of avian influenza virus hemagglutinin by recombinant fowlpox virus.
Vaccinia
Expression of cloned vaccinia virus DNA sequences introduced into animal cells.
Vaccinia
Expression of functional parvoviral NS1 from recombinant vaccinia virus: effects of mutations in the nucleotide-binding motif.
Vaccinia
Expression of herpes simplex virus thymidine kinase, mediated by vaccinia virus early promoters.
Vaccinia
Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells.
Vaccinia
Expression of rabies virus glycoprotein from a recombinant vaccinia virus.
Vaccinia
Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions.
Vaccinia
Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity.
Vaccinia
Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity.
Vaccinia
Expression of the major glycoprotein G of human respiratory syncytial virus from recombinant vaccinia virus vectors.
Vaccinia
Expression vector pT7:TKII for the synthesis of authentic biologically active RNA encoding vaccinia virus thymidine kinase.
Vaccinia
Failure of poxvirus replication in the presence of an inhibitor of nucleolar RNA synthesis.
Vaccinia
Fidelity of homologous recombination in vaccinia virus DNA.
Vaccinia
Fine structure analysis and nucleotide sequence of the vaccinia virus thymidine kinase gene.
Vaccinia
First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells.
Vaccinia
Fluorescent Tagged Vaccinia Virus Genome Allows Rapid and Efficient Measurement of Oncolytic Potential and Discovery of Oncolytic Modulators.
Vaccinia
Gene therapy for malignant mesothelioma: beyond the infant years.
Vaccinia
Gene translocations in poxviruses: the fowlpox virus thymidine kinase gene is flanked by 15 bp direct repeats and occupies the locus which in vaccinia virus is occupied by the ribonucleotide reductase large subunit gene.
Vaccinia
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.
Vaccinia
Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2.
Vaccinia
High-frequency homologous recombination in vaccinia virus DNA.
Vaccinia
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells.
Vaccinia
Identification and characterization of an extracellular envelope glycoprotein affecting vaccinia virus egress.
Vaccinia
Identification and characterization of the thymidine kinase gene of Yaba virus.
Vaccinia
Identification and cloning of the fowlpox virus thymidine kinase gene using vaccinia virus.
Vaccinia
Identification of a Bohle iridovirus thymidine kinase gene and demonstration of activity using vaccinia virus.
Vaccinia
Identification of the ATP-binding domain of vaccinia virus thymidine kinase.
Vaccinia
Identification of vaccinia promoters by heterologous expression of hepatitis B surface antigen in mouse cells infected by recombinant vaccinia viruses.
Vaccinia
Immunization with a vaccinia recombinant expressing the F protein protects rabbits from challenge with a lethal dose of rinderpest virus.
Vaccinia
Improved recombinant LC16m0 or LC16m8 vaccinia virus successfully expressing hepatitis B surface antigen.
Vaccinia
Improved safety of a replication-competent poxvirus-based HIV vaccine with the introduction of the HSV-TK/GCV suicide gene system.
Vaccinia
In vivo recognition of orf virus early transcriptional promoters in a vaccinia virus recombinant.
Vaccinia
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Vaccinia
Induction of protective immunity in animals vaccinated with recombinant vaccinia viruses that express PreM and E glycoproteins of Japanese encephalitis virus.
Vaccinia
Infectious bursal disease virus structural protein VP2 expressed by a fowlpox virus recombinant confers protection against disease in chickens.
Vaccinia
Infectious poxvirus vectors have capacity for at least 25 000 base pairs of foreign DNA.
Vaccinia
INHIBITION OF THYMIDINE KINASE FORMATION IN LM (TK-) CELLS SIMULTANEOUSLY INFECTED WITH VACCINIA AND A THYMIDINE KINASELESS VACCINIA MUTANT.
Vaccinia
Inhibition of vaccinia virus growth by zinc ions: effects on early RNA and thymidine kinase synthesis.
Vaccinia
Inhibition of vaccinia virus thymidine kinase by the distal products of its own metabolic pathway.
Vaccinia
INHIBITORY EFFECT OF INTERFERON ON THE INDUCTION OF THYMIDINE KINASE IN VACCINIA VIRUS-INFECTED CHICK EMBRYO FIBROBLASTS.
Vaccinia
Inhibitory effects of puromycin and fluorophenylalanine on induction of thymidine kinase by vaccinia infected L-cells.
Vaccinia
Insertion sites for recombinant vaccinia virus construction: effects on expression of a foreign protein.
Vaccinia
Interferon sensitivity of expression of histone H5/H1(0)-vaccinia thymidine kinase fusion genes expressed by recombinant vaccinia viruses is enhanced by shortening the histone sequence.
Vaccinia
Intracellular processing of the porcine coronavirus transmissible gastroenteritis virus spike protein expressed by recombinant vaccinia virus.
Vaccinia
Intratumoral injection of GM-CSF gene encoded recombinant vaccinia virus elicits potent antitumor response in a mixture melanoma model.
Vaccinia
Introduction of foreign DNA into the vaccinia virus genome by in vitro ligation: recombination-independent selectable cloning vectors.
Vaccinia
Isolation of cis-acting vaccinia virus DNA fragments promoting the expression of herpes simplex virus thymidine kinase by recombinant viruses.
Vaccinia
JX-594, a targeted oncolytic poxvirus for the treatment of cancer.
Vaccinia
KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.
Vaccinia
Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus.
Vaccinia
Locating a nucleotide-binding site in the thymidine kinase of vaccinia virus and of herpes simplex virus by scoring triply aligned protein sequences.
Vaccinia
Mapping and identification of the vaccinia virus thymidine kinase gene.
Vaccinia
Mapping of a vaccinia host range sequence by insertion into the viral thymidine kinase gene.
Vaccinia
Mapping of the vaccinia virus thymidine kinase gene by marker rescue and by cell-free translation of selected mRNA.
Vaccinia
Mapping thymidine kinase-deficient mutants of vaccinia virus by marker rescue with hybrid plasmid DNAs containing portions of the HindIII-J fragment of virus DNA.
Vaccinia
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Vaccinia
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Vaccinia
Morphological and molecular characterization of the poxvirus BeAn 58058.
Vaccinia
Multiple-cloning-site plasmids for the rapid construction of recombinant poxviruses.
Vaccinia
Novel codon utilization within the vaccinia virus thymidine kinase gene.
Vaccinia
Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity.
Vaccinia
Nucleotide sequence analysis and expression from recombinant vectors demonstrate that the attachment protein G of bovine respiratory syncytial virus is distinct from that of human respiratory syncytial virus.
Vaccinia
Nucleotide sequence analysis of the bovine respiratory syncytial virus fusion protein mRNA and expression from a recombinant vaccinia virus.
Vaccinia
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.
Vaccinia
Nucleotide sequence of the thymidine kinase gene of raccoon poxvirus.
Vaccinia
Nucleotide sequence of the vaccinia virus thymidine kinase gene and the nature of spontaneous frameshift mutations.
Vaccinia
Oncolytic efficacy of thymidine kinase-deleted vaccinia virus strain Guang9.
Vaccinia
Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis.
Vaccinia
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Vaccinia
Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment.
Vaccinia
One hundred base pairs of 5' flanking sequence of a vaccinia virus late gene are sufficient to temporally regulate late transcription.
Vaccinia
Orthopoxvirus DNA in eurasian lynx, sweden.
Vaccinia
Passatempo virus, a vaccinia virus strain, Brazil.
Vaccinia
Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.
Vaccinia
Preclinical Evaluation of the Oncolytic Vaccinia Virus TG6002 by Translational Research on Canine Breast Cancer.
Vaccinia
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus.
Vaccinia
Preparation of candidate vaccinia-vectored vaccines for haemorrhagic fever with renal syndrome.
Vaccinia
Prevention of vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression.
Vaccinia
Proceedings: Control of thymidine kinase synthesis in the cells infected with IHD strain of vaccinia virus.
Vaccinia
Protection of mice with vaccinia virus recombinants that express the rabies nucleoprotein.
Vaccinia
Purification of vaccinia virus-induced thymidine kinase activity from [35S]methionine-labeled cells.
Vaccinia
Quaternary structure of vaccinia virus thymidine kinase.
Vaccinia
Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963.
Vaccinia
Recombinant capripoxvirus expressing the hemagglutinin protein gene of rinderpest virus: protection of cattle against rinderpest and lumpy skin disease viruses.
Vaccinia
Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 (IL-4) does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon.
Vaccinia
Recombinant vaccinia/Venezuelan equine encephalitis (VEE) virus expresses VEE structural proteins.
Vaccinia
Reduced steady-state levels of vaccinia virus-specific early mRNAs in interferon-treated chick embryo fibroblasts.
Vaccinia
Regulation of expression and nucleotide sequence of a late vaccinia virus gene.
Vaccinia
Regulation of histone H5 and H1 zero gene expression under the control of vaccinia virus-specific sequences in interferon-treated chick embryo fibroblasts.
Vaccinia
Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation.
Vaccinia
Rescue of Sendai virus from viral ribonucleoprotein-transfected cells by infection with recombinant vaccinia viruses carrying Sendai virus L and P/C genes.
Vaccinia
Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein.
Vaccinia
Safety studies and viral shedding of intramuscular administration of oncolytic vaccinia virus TG6002 in healthy beagle dogs.
Vaccinia
Selection of recombinant vaccinia viruses (Tian Tan strain) expressing hepatitis B virus surface antigen by using beta-galactosidase as a marker.
Vaccinia
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
Vaccinia
Similar genetic organization between a region of fowlpox virus DNA and the vaccinia virus HindIII J fragment despite divergent location of the thymidine kinase gene.
Vaccinia
Simultaneous expression of the Lassa virus N and GPC genes from a single recombinant vaccinia virus.
Vaccinia
Single capripoxvirus recombinant vaccine for the protection of cattle against rinderpest and lumpy skin disease.
Vaccinia
Site-directed mutagenesis of a conserved domain in vaccinia virus thymidine kinase. Evidence for a potential role in magnesium binding.
Vaccinia
SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC.
Vaccinia
Structure of vaccinia virus early promoters.
Vaccinia
Structure of vaccinia virus late promoters.
Vaccinia
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.
Vaccinia
Studies on the mechanism of action of interferon: inhibition of thymidine kinase induction in vaccinia virus-infected chick embryo cells.
Vaccinia
Substrate specificity of vaccinia virus thymidylate kinase.
Vaccinia
Synthesis of vaccinia virus thymidine kinase in microinjected Xenopus oocytes.
Vaccinia
Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes.
Vaccinia
Target Therapy With Vaccinia Virus Harboring IL-24 For Human Breast Cancer.
Vaccinia
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Vaccinia
The 5' noncoding region sequence of the Choristoneura biennis entomopoxvirus spheroidin gene functions as an efficient late promoter in the mammalian vaccinia expression system.
Vaccinia
The development and use of a vaccinia-rabies recombinant oral vaccine for the control of wildlife rabies; a link between Jenner and Pasteur.
Vaccinia
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
Vaccinia
The nucleotide sequence of the chicken thymidine kinase gene and the relationship of its predicted polypeptide to that of the vaccinia virus thymidine kinase.
Vaccinia
The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers.
Vaccinia
The use of recombinant vaccinia virus to generate monoclonal antibodies against the cell-surface glycoprotein endoglin.
Vaccinia
Transactivation by herpes simplex virus proteins ICP4 and ICP0 in vaccinia virus infected cells.
Vaccinia
Translation of reovirus RNA species m1 can initiate at either of the first two in-frame initiation codons.
Vaccinia
Vaccinia as a vector for gene delivery.
Vaccinia
Vaccinia virus DNA ligase is nonessential for virus replication: recovery of plasmids from virus-infected cells.
Vaccinia
Vaccinia virus encodes a thymidylate kinase gene: sequence and transcriptional mapping.
Vaccinia
Vaccinia virus encodes an active thymidylate kinase that complements a cdc8 mutant of Saccharomyces cerevisiae.
Vaccinia
Vaccinia virus expressing IL-37 promotes antitumor immune responses in hepatocellular carcinoma.
Vaccinia
Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.
Vaccinia
Vaccinia virus recombinants expressing rabiesvirus glycoprotein protect against rabies.
Vaccinia
Vaccinia virus thymidine kinase and neighboring genes: mRNAs and polypeptides of wild-type virus and putative nonsense mutants.
Vaccinia
Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs.
Vaccinia
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins.
Vaccinia
[Development of the drug oncolytic immunotherapy based on vaccinia viruses (Vaccinia virus, Orthopoxvirus, Chordopoxvirinae, Poxviridae) against breast cancer.]
Vaccinia
[Double recombinants of the vaccinia virus expressing hepatitis B virus surface antigen and herpes simplex virus thymidine kinase]
Vaccinia
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
Vaccinia
[The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus]
Vaccinia
[Therapeutic effect of vaccinia virus secreting granulocyte-macrophage colony-stimulating factor on pulmonary metastatic melanoma]
Vascular Diseases
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Vesicular Stomatitis
Autonomous Cell Migration to CSF1 Sources via a Synthetic Protein-Based System.
Vesicular Stomatitis
Engineered Proteins Program Mammalian Cells to Target Inflammatory Disease Sites.
Vesicular Stomatitis
Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys.
Vesicular Stomatitis
Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease.
Vesicular Stomatitis
Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles.
Vesicular Stomatitis
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
Vesicular Stomatitis
[Vesicular stomatitis virus G-protein retrovector mediated a herpes simplex virus thymidine kinase gene transduction and expression in the human retinal pigment epithelial cells]
Virus Diseases
Acyclovir in mouse cytomegalovirus infections.
Virus Diseases
Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets.
Virus Diseases
Antiviral activity of a selective ribonucleotide reductase inhibitor against acyclovir-resistant herpes simplex virus type 1 in vivo.
Virus Diseases
Application of an in vitro assay for serum thymidine kinase: results on viral disease and malignancies in humans.
Virus Diseases
Effect of a thymidine kinase inhibitor (L-653,180) on antiviral treatment of experimental herpes simplex virus infection in mice.
Virus Diseases
Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts.
Virus Diseases
Immune gene expression profile of Penaeus monodon in response to marine yeast glucan application and white spot syndrome virus challenge.
Virus Diseases
Induction of thymidine kinase and DNase in varicella-zoster virus-infected cells and kinetic properties of the virus-induced thymidine kinase.
Virus Diseases
Marine actinomycetes as bioremediators in Penaeus monodon rearing system.
Virus Diseases
Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
Virus Diseases
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.
Virus Diseases
Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.
Virus Diseases
Nucleic acid related compounds. 65. New syntheses of 1-(beta-D-arabinofuranosyl)-5(E)-(2-iodovinyl)uracil (IVAraU) from vinylsilane precursors. Radioiodine uptake as a marker for thymidine kinase positive herpes viral infections.
Virus Diseases
Passatempo virus, a vaccinia virus strain, Brazil.
Virus Diseases
Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer.
Virus Diseases
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Virus Diseases
Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes.
Virus Diseases
Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy.
Virus Diseases
Regulated expression of stably transfected herpes simplex virus thymidine kinase genes in continuous cell lines expressing a temperature-sensitive mutant form of the immediate-early protein ICP4.
Virus Diseases
Serum thymidine kinase in transplant patients: its relation to cytomegalovirus activity, renal transplant rejection and its use for monitoring of antiviral therapy.
Virus Diseases
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Virus Diseases
The requirement of simian virus 40 gene A product for the stimulation of cellular thymidine kinase activity after viral infection.
Virus Diseases
Transient control of a virus-induced immunopathology by genetic immunosuppression.
Virus Diseases
[Prospects and current data in antiviral chemotherapy]
Vitamin B 12 Deficiency
Serum thymidine kinase in vitamin B12 deficiency.
Vitiligo
Extensive vitiligo after ganciclovir treatment of GvHD in a patient who had received donor T cells expressing herpes simplex virus thymidine kinase.
Vitreoretinopathy, Proliferative
Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy?
Vitreoretinopathy, Proliferative
Ocular gene therapy: experimental studies and clinical possibilities.
Wiskott-Aldrich Syndrome
Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus.
Wiskott-Aldrich Syndrome
Recurrent aciclovir-resistant herpes simplex in a child with Wiskott-Aldrich syndrome.
Wolfram Syndrome
Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein.
X-Linked Combined Immunodeficiency Diseases
Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells.
Zoonoses
Inhibition of B virus (Cercopithecine herpesvirus 1) by Conventional and Experimental Antiviral Compounds.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.