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Information on EC 2.7.1.209 - L-erythrulose 1-kinase and Organism(s) Mycolicibacterium smegmatis and UniProt Accession A0R758

for references in articles please use BRENDA:EC2.7.1.209
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IUBMB Comments
The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol.
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This record set is specific for:
Mycolicibacterium smegmatis
UNIPROT: A0R758
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The taxonomic range for the selected organisms is: Mycolicibacterium smegmatis
The enzyme appears in selected viruses and cellular organisms
Synonyms
L-erythrulose 4-kinase, lerK, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L-erythrulose 4-kinase
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
ATP:L-erythrulose 1-phosphotransferase
The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + D-erythrulose
ADP + D-erythrulose 4-phosphate
show the reaction diagram
catalytic efficiency is 4fold lower compared to L-erythrulose as substrate
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-
?
ATP + dihydroxyacetone
?
show the reaction diagram
catalytic efficiency is about 100fold lower compared to L-erythrulose as substrate
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-
?
ATP + L-erythrulose
ADP + L-erythrulose 4-phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + L-erythrulose
ADP + L-erythrulose 4-phosphate
show the reaction diagram
the enzyme participates in the degradation of L-threitol
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-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0106
D-erythrulose
pH and temperature not specified in the publication
0.0378
dihydroxyacetone
pH and temperature not specified in the publication
0.003
L-erythrulose
pH and temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.6
D-erythrulose
pH and temperature not specified in the publication
2.12
dihydroxyacetone
pH and temperature not specified in the publication
1.79
L-erythrulose
pH and temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
150.9
D-erythrulose
pH and temperature not specified in the publication
56.1
dihydroxyacetone
pH and temperature not specified in the publication
597
L-erythrulose
pH and temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme participates in the degradation of L-threitol
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Huang, H.; Carter, M.S.; Vetting, M.W.; Al-Obaidi, N.; Patskovsky, Y.; Almo, S.C.; Gerlt, J.A.
A general strategy for the discovery of metabolic pathways: D-threitol, L-threitol, and erythritol utilization in Mycobacterium smegmatis
J. Am. Chem. Soc.
137
14570-14573
2015
Mycolicibacterium smegmatis (A0R758)
Manually annotated by BRENDA team