Information on EC 2.7.1.206 - protein-Npi-phosphohistidine-L-sorbose phosphotransferase

for references in articles please use BRENDA:EC2.7.1.206
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
2.7.1.206
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RECOMMENDED NAME
GeneOntology No.
protein-Npi-phosphohistidine-L-sorbose phosphotransferase
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REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
[protein]-Npi-phospho-L-histidine + L-sorbose[side 1] = [protein]-L-histidine + L-sorbose 1-phosphate[side 2]
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Fructose and mannose metabolism
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SYSTEMATIC NAME
IUBMB Comments
protein-Npi-phospho-L-histidine:L-sorbose Npi-phosphotransferase
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
EIIASor and EEIBSor and EIICSor and EIIDSor
Q9RGG5, Q9RGG4, Q9RGG3, Q9RGG2
UniProt
Manually annotated by BRENDA team
EIIASor and EEIBSor and EIICSor and EIIDSor
Q9RGG5, Q9RGG4, Q9RGG3, Q9RGG2
UniProt
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + L-sorbose[side 1]
[protein]-L-histidine + L-sorbose 1-phosphate[side 2]
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + L-sorbose[side 1]
[protein]-L-histidine + L-sorbose 1-phosphate[side 2]
show the reaction diagram
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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PDB
SCOP
CATH
UNIPROT
ORGANISM
Homo sapiens;
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
14500
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x * 14500, domain EIIASor, SDS-PAGE
14509
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x * 14509, domain EIIASor, calculated from amino acid sequence
14985
Q9RGG5; Q9RGG4; Q9RGG3; Q9RGG2;
x * 14985, domain EIIASor, calculated from amino acid sequence
18304
Q9RGG5; Q9RGG4; Q9RGG3; Q9RGG2;
x * 18304, domain EIIBSor, calculated from amino acid sequence
18457
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x * 18457, domain EIIBSor, calculated from amino acid sequence
19000
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x * 19000, domain EIIBSor, SDS-PAGE
25000
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x * 25000, domain EIICSor, SDS-PAGE
27000
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x * 27000, domain EIIDSor, SDS-PAGE
27876
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x * 27876, domain EIICSor, calculated from amino acid sequence
29002
Q9RGG5; Q9RGG4; Q9RGG3; Q9RGG2;
x * 29002, domain EIICSor, calculated from amino acid sequence
29370
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x * 29370, domain EIIDSor, calculated from amino acid sequence
30788
Q9RGG5; Q9RGG4; Q9RGG3; Q9RGG2;
x * 30788, domain EIIDSor, calculated from amino acid sequence
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.7.1.206)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)