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Information on EC 2.7.1.2 - glucokinase and Organism(s) Homo sapiens and UniProt Accession P35557
for references in articles please use BRENDA:EC2.7.1.2
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EC Tree 2 Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.2 glucokinase
IUBMB Comments
A group of enzymes found in invertebrates and microorganisms that are highly specific for glucose.
The enzyme appears in selected viruses and cellular organisms
- 2.7.1.2
- pancreatic
- islet
- hepatocytes
- hexokinase
- mellitus
- glycogen
- beta-cell
- hyperglycemia
- glucose-6-phosphatase
- fructose
- pancreas
- phosphoenolpyruvate
-
maturity-onset
-
carboxykinase
- glucagon
-
glucose-stimulated
-
glucose-induced
- 6-phosphate
- triglyceride
-
gluconeogenesis
-
phosphofructokinase
-
hypoglycemic
-
monogenic
-
antidiabetic
-
non-insulin-dependent
- pepck
-
gluconeogenic
- c-peptide
-
ins-1e
- insulinomas
- glp-1
- niddm
-
insulin-secreting
- sulfonylurea
- g6pase
-
glut-2
- hyperinsulinemia
-
glucose-sensing
-
glucose-dependent
-
insulin-producing
-
glucose-lowering
-
2.7.1.1
-
2,6-bisphosphate
-
kcnj11
- substrate-2
- hyperinsulinism
-
perivenous
- fructokinase
- diazoxide
-
glucose-responsive
showSynonyms
glucokinase, atp-dependent glucokinase, tcglck, atp-glk, sgglka, tte0090, klglk1, sw2155, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
glucokinase (phosphorylating)
-
-
-
-
kinase, gluco- (phosphorylating)
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
MetaCyc
1,3-propanediol biosynthesis (engineered), Bifidobacterium shunt, GDP-alpha-D-glucose biosynthesis, glucose and glucose-1-phosphate degradation, glycogen degradation I, glycogen degradation II, glycolysis III (from glucose), heterolactic fermentation, sucrose biosynthesis II, sucrose degradation III (sucrose invertase), trehalose degradation I (low osmolarity), trehalose degradation II (cytosolic), trehalose degradation IV, trehalose degradation V, UDP-N-acetyl-D-galactosamine biosynthesis II, UDP-N-acetyl-D-glucosamine biosynthesis II
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SYSTEMATIC NAME
IUBMB Comments
ATP:D-glucose 6-phosphotransferase
A group of enzymes found in invertebrates and microorganisms that are highly specific for glucose.
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CAS REGISTRY NUMBER
COMMENTARY
9001-36-9
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics.
Adenoma, Islet Cell
Defective regulation of glucokinase in rat pancreatic islet cell tumours.
Anemia
[Leading criteria of reticulocyte maturation. 3. Behavior of hexokinase and glucokinase of red blood cells during a bleeding anemia of the rabbit]
Atherosclerosis
Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice.
Atherosclerosis
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Atherosclerosis
The APOE?3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis.
Breast Neoplasms
Molecular and disease association of gestational diabetes mellitus affected mother and placental datasets reveal a strong link between insulin growth factor (IGF) genes in amino acid transport pathway: A network biology approach.
Brucellosis
Studies on recombinant glucokinase (r-glk) protein of Brucella abortus as a candidate vaccine molecule for brucellosis.
Burkitt Lymphoma
Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening.
Carcinogenesis
First evidence of changes in enzyme kinetics and stability of glucokinase affected by somatic cancer-associated variations.
Carcinogenesis
[CHANGES IN GLUCOKINASE AND HEXOKINASE CONTENT OF THE RAT LIVER AFTER FASTING, DURING CARCINOGENESIS AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
Carcinoid Tumor
Thymic Carcinoid as the First Manifestation of Multiple Endocrine Neoplasia Type 1 Syndrome: A Case Report and Review of the Literature.
Carcinoma
Isoenzyme shift from glucokinase to hexokinase is not an early but a late event in hepatocarcinogenesis.
Carcinoma, Hepatocellular
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
Carcinoma, Hepatocellular
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.
Carcinoma, Hepatocellular
Alteration of enzyme function of the type II hexokinase C-terminal half on replacements of restricted regions by corresponding regions of glucokinase.
Carcinoma, Hepatocellular
Characterization of the 5' flanking region of rat glucokinase gene.
Carcinoma, Hepatocellular
Glucokinase expression in rat hepatoma cells induces glucose uptake and is rate limiting in glucose utilization.
Carcinoma, Hepatocellular
Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.
Carcinoma, Hepatocellular
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Carcinoma, Hepatocellular
Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene.
Carcinoma, Hepatocellular
Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro.
Carcinoma, Hepatocellular
Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase.
Carcinoma, Hepatocellular
The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.
Carcinoma, Hepatocellular
[Activity of enzymes of glycolysis and gluconeogenesis in primary hepatomas induced by diethylnitrosamine]
Carcinoma, Hepatocellular
[Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis]
Carcinoma, Hepatocellular
[Biochemical features of the liver of high and low cancer mouse strains and primary spontaneous hepatomas]
Carcinoma, Hepatocellular
[CHANGES IN GLUCOKINASE AND HEXOKINASE CONTENT OF THE RAT LIVER AFTER FASTING, DURING CARCINOGENESIS AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
Carcinoma, Hepatocellular
[Noradrenaline and glycogen content and the activity of several enzymes of carbohydrate metabolism in normal, embryonic, and partly denervated livers and in hepatomas of the rat]
Carcinoma, Hepatocellular
[Some characteristics of isoenzymic spectrum of hexokinase and glucose levels in hepatomas and liver of the host]
Chagas Disease
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment - A Stone Killing Two Birds?
Chagas Disease
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.
Colorectal Neoplasms
Genetic Variants, Prediagnostic Circulating Levels of Insulin-like Growth Factors, Insulin, and Glucose and the Risk of Colorectal Cancer: The Multiethnic Cohort Study.
Coma
Effect of total hepatectomy on selected cerebral substrates and enzymes of the glycolytic pathways and Krebs cycle.
Congenital Hyperinsulinism
A report of 2 new cases of MODY2 and review of the literature: Implications in the search for type 2 Diabetes drugs.
Congenital Hyperinsulinism
Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.
Congenital Hyperinsulinism
Clinical and enzymatic phenotypes in congenital hyperinsulinemic hypoglycemia due to glucokinase-activating mutations: A report of two cases and a brief overview of the literature.
Congenital Hyperinsulinism
Conformational transition pathway in the activation process of allosteric glucokinase.
Congenital Hyperinsulinism
Conformational transition pathway in the allosteric process of human glucokinase.
Congenital Hyperinsulinism
Evidence-based tailoring of bioinformatics approaches to optimize methods that predict the effects of nonsynonymous amino acid substitutions in glucokinase.
Congenital Hyperinsulinism
Familial hyperinsulinism caused by an activating glucokinase mutation.
Congenital Hyperinsulinism
Glucokinase mutation-a rare cause of recurrent hypoglycemia in adults: a case report and literature review.
Congenital Hyperinsulinism
Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.
Congenital Hyperinsulinism
Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.
Congenital Hyperinsulinism
Mechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates.
Congenital Hyperinsulinism
Mechanistic Origins of Enzyme Activation in Human Glucokinase Variants Associated with Congenital Hyperinsulinism.
Congenital Hyperinsulinism
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
Congenital Hyperinsulinism
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ? cells.
Congenital Hyperinsulinism
[Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.]
Coronary Artery Disease
Association of GCKR Gene Polymorphisms with the Risk of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in a Chinese Northern Han Population.
Coronary Artery Disease
Cardiovascular risk assessment by coronary artery calcium score in subjects with maturity-onset diabetes of the young caused by glucokinase mutations.
Coronary Artery Disease
G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus.
Coronary Artery Disease
Polymorphisms in the GCKR are associated with serum lipid traits, the risk of coronary artery disease and ischemic stroke.
Diabetes Complications
Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q.
Diabetes Complications
Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing.
Diabetes Mellitus
A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus.
Diabetes Mellitus
A De Novo Whole GCK Gene Deletion Not Detected by Gene Sequencing, in a Boy with Phenotypic GCK Insufficiency.
Diabetes Mellitus
A family with novel homozygous deletion mutation (c.1255delT; p.Phe419Serfs*12) in the glucokinase gene, which is a rare cause of permanent neonatal diabetes mellitus.
Diabetes Mellitus
A genetic marker at the glucokinase gene locus for type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles.
Diabetes Mellitus
A glucokinase gene mutation in a young boy with diabetes mellitus, hyperinsulinemia, and insulin resistance.
Diabetes Mellitus
A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.
Diabetes Mellitus
A new compound heterozygosis for inactivating mutations in the glucokinase gene as cause of permanent neonatal diabetes mellitus (PNDM) in double-first cousins.
Diabetes Mellitus
A patent review of glucokinase activators and disruptors of the glucokinase--glucokinase regulatory protein interaction: 2011-2014.
Diabetes Mellitus
A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study).
Diabetes Mellitus
Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon model.
Diabetes Mellitus
Author Correction: Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
Characterization of a third simple tandem repeat polymorphism in the human glucokinase gene.
Diabetes Mellitus
Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes.
Diabetes Mellitus
Comment on Rudland et al. Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c. Diabetes Care 2016;39:50-52.
Diabetes Mellitus
Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment.
Diabetes Mellitus
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Diabetes Mellitus
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.
Diabetes Mellitus
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Diabetes Mellitus
Dose-Dependent Effect of Piragliatin, a Glucokinase Activator, on the QT Interval Following Short-Term Multiple Doses in Patients With Type 2 Diabetes Mellitus.
Diabetes Mellitus
Dose-ranging study with the glucokinase activator AZD1656 as monotherapy in Japanese patients with type 2 diabetes mellitus.
Diabetes Mellitus
Dose-ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin.
Diabetes Mellitus
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
Diabetes Mellitus
Early-onset type 2 (non-insulin-dependent) diabetes mellitus is associated with glucokinase locus, but not with adenosine deaminase locus, in the Japanese population.
Diabetes Mellitus
Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1 alpha and glucokinase.
Diabetes Mellitus
Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus.
Diabetes Mellitus
Effects of piragliatin, a glucokinase activator, on fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus.
Diabetes Mellitus
Efficacy and safety of glucokinase activators for type 2 diabetes mellitus therapy: a meta-analysis of double-blind randomized controlled trials.
Diabetes Mellitus
Essential role of glucokinase in the protection of pancreatic ? cells to the glucose energetic status.
Diabetes Mellitus
Ethnopharmacological perspectives of glucokinase activators in the treatment of diabetes mellitus.
Diabetes Mellitus
Familial adult onset hyperinsulinism due to an activating glucokinase mutation: implications for pharmacological glucokinase activation.
Diabetes Mellitus
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
Diabetes Mellitus
Four novel cases of permanent neonatal diabetes mellitus caused by homozygous mutations in the glucokinase gene.
Diabetes Mellitus
G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus.
Diabetes Mellitus
Genetic causes of maturity onset diabetes of the young may be less prevalent in American pregnant women recently diagnosed with diabetes mellitus than in previously studied European populations.
Diabetes Mellitus
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
Diabetes Mellitus
Glucokinase and candidate genes for type 2 (non-insulin-dependent) diabetes mellitus.
Diabetes Mellitus
Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes.
Diabetes Mellitus
Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.
Diabetes Mellitus
Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.
Diabetes Mellitus
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
Diabetes Mellitus
Glycemic Effect and Safety of a Systemic, Partial Glucokinase Activator, PF-04937319, in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin-A Randomized, Crossover, Active-Controlled Study.
Diabetes Mellitus
High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population.
Diabetes Mellitus
High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP).
Diabetes Mellitus
Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.
Diabetes Mellitus
Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA.
Diabetes Mellitus
Human pancreatic beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13.
Diabetes Mellitus
Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.
Diabetes Mellitus
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
Diabetes Mellitus
Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus.
Diabetes Mellitus
Identification of glucokinase mutations in subjects with gestational diabetes mellitus.
Diabetes Mellitus
Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus.
Diabetes Mellitus
Importance of glucokinase -258G/A polymorphism in Asian Indians with post-transplant and type 2 diabetes mellitus.
Diabetes Mellitus
In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-?-D-xylopyranosyl isolated from Swertia corymbosa.
Diabetes Mellitus
Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism.
Diabetes Mellitus
Lack of Potential Pharmacokinetic and Pharmacodynamic Interactions Between Piragliatin, a Glucokinase Activator, and Simvastatin in Patients With Type 2 Diabetes Mellitus.
Diabetes Mellitus
Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD.
Diabetes Mellitus
Linkage analysis does not support a role for glucokinase gene in the aetiology of type 2 diabetes mellitus among north western Italians.
Diabetes Mellitus
Linkage analysis of the glucokinase locus in familial type 2 (non-insulin-dependent) diabetic pedigrees.
Diabetes Mellitus
LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats.
Diabetes Mellitus
Maturity Onset Diabetes of the Young due to Glucokinase, HNF1-A, HNF1-B, and HNF4-A Mutations in a Cohort of Turkish Children Diagnosed as Type 1 Diabetes Mellitus.
Diabetes Mellitus
Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.
Diabetes Mellitus
Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.
Diabetes Mellitus
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times.
Diabetes Mellitus
Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.
Diabetes Mellitus
Molecular screening of the glucokinase gene in familial type 2 (non-insulin-dependent) diabetes mellitus.
Diabetes Mellitus
Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus.
Diabetes Mellitus
Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetes Mellitus
Neonatal diabetes mellitus due to complete glucokinase deficiency.
Diabetes Mellitus
New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer).
Diabetes Mellitus
NIDDM--genetic marker; glucose transporter, glucokinase, and mitochondria gene.
Diabetes Mellitus
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Diabetes Mellitus
Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.
Diabetes Mellitus
Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.
Diabetes Mellitus
Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy.
Diabetes Mellitus
Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study.
Diabetes Mellitus
Polymorphism of glucokinase gene in non-insulin dependent diabetes mellitus.
Diabetes Mellitus
Polymorphisms in the GCK gene increase the risk of clopidogrel resistance in stable coronary artery disease (SCAD) patients.
Diabetes Mellitus
Polymorphisms rs144723656, rs2268574, and rs2268575 of the glucokinase gene are not associated with obese women with type 2 diabetes mellitus.
Diabetes Mellitus
Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians.
Diabetes Mellitus
Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Diabetes Mellitus
Raised blood glucose due to heterozygous glucokinase gene mutation (GCK-MODY) diagnosed for the first time in pregnancy: The dilemmas and successful management - Case report and review of literature.
Diabetes Mellitus
Recent clinical advances of glucokinase activators in the treatment of diabetes mellitus type 2.
Diabetes Mellitus
Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics.
Diabetes Mellitus
Recent Updates on Glucokinase Activators and Glucokinase Regulatory Protein Disrupters for the Treatment of Type 2 Diabetes Mellitus.
Diabetes Mellitus
Recent updates on glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
Repair of diverse diabetic defects of ?-cells in man and mouse by pharmacological glucokinase activation.
Diabetes Mellitus
Routine mutation screening of HNF-1alpha and GCK genes in MODY diagnosis: how effective are the techniques of DHPLC and direct sequencing used in combination?
Diabetes Mellitus
Safety, pharmacokinetics and pharmacodynamics of multiple-ascending doses of the novel glucokinase activator AZD1656 in patients with type 2 diabetes mellitus.
Diabetes Mellitus
Safety, Pharmacokinetics, and Pharmacodynamics of Globalagliatin, a Glucokinase Activator, in Chinese Patients with Type 2 Diabetes Mellitus: A Randomized, Phase Ib, 28-day Ascending Dose Study.
Diabetes Mellitus
Screening of mutations and polymorphisms in the glucokinase gene in Czech diabetic and healthy control populations.
Diabetes Mellitus
Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients.
Diabetes Mellitus
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.
Diabetes Mellitus
Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).
Diabetes Mellitus
The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).
Diabetes Mellitus
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus
The effects and safety of activators of glucokinase versus placebo in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.
Diabetes Mellitus
The efficacy and safety of glucokinase activators for the treatment of type-2 diabetes mellitus: A protocol for systematic review and meta-analysis.
Diabetes Mellitus
The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food.
Diabetes Mellitus
The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent.
Diabetes Mellitus
The population association of glucokinase gene with type 2 (noninsulin-dependent) diabetes mellitus in Chinese.
Diabetes Mellitus
Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online.
Diabetes Mellitus
Tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator AZD1656, after single ascending doses in healthy subjects during euglycemic clamp.
Diabetes Mellitus
Translational Modeling and Simulation in Supporting Early-Phase Clinical Development of New Drug: A Learn-Research-Confirm Process.
Diabetes Mellitus
Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes.
Diabetes Mellitus
Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus.
Diabetes Mellitus
Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family.
Diabetes Mellitus
Variability in the age at diagnosis of diabetes in two unrelated patients with a homozygous glucokinase gene mutation.
Diabetes Mellitus
[Clinical studies on the serum glucokinase activity values. 1. Erythrocyte glucokinase activity values in normal infants and children, in ekiri-like syndrome, in diabetes mellitus, and in liver diseases.]
Diabetes Mellitus
[Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery]
Diabetes Mellitus
[Salicylic acid derivatives as simplified and novel GK small molecule activators].
Diabetes Mellitus, Experimental
[Incorporation of S35 labelled methionine in the liver proteins of rats with alloxan diabetes in conditions of block or "circumvention" of the glucokinase reaction.]
Diabetes Mellitus, Type 1
Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.
Diabetes Mellitus, Type 1
Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations.
Diabetes Mellitus, Type 1
Circulating ghrelin level is higher in HNF1A-MODY and GCK-MODY than in polygenic forms of diabetes mellitus.
Diabetes Mellitus, Type 1
Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes.
Diabetes Mellitus, Type 1
High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes.
Diabetes Mellitus, Type 1
Lack of association between type 1 diabetes and the glucokinase gene.
Diabetes Mellitus, Type 1
Less but better: cardioprotective lipid profile of patients with GCK-MODY despite lower HDL cholesterol level.
Diabetes Mellitus, Type 1
Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.
Diabetes Mellitus, Type 1
Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes.
Diabetes Mellitus, Type 1
Maturity Onset Diabetes of the Young due to Glucokinase, HNF1-A, HNF1-B, and HNF4-A Mutations in a Cohort of Turkish Children Diagnosed as Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 1
Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Molecular and functional changes in glucokinase expression in the brainstem dorsal vagal complex in a murine model of type 1 diabetes.
Diabetes Mellitus, Type 1
Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile.
Diabetes Mellitus, Type 1
Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats.
Diabetes Mellitus, Type 1
The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).
Diabetes Mellitus, Type 1
The coexistence of type 1 diabetes, MODY2 and metabolic syndrome in a young girl.
Diabetes Mellitus, Type 1
The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes.
Diabetes Mellitus, Type 1
Therapy targeting beta-cell survival and function in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus.
Diabetes Mellitus, Type 2
A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies.
Diabetes Mellitus, Type 2
A Comprehensive Analysis of Hungarian MODY Patients-Part II: Glucokinase MODY Is the Most Prevalent Subtype Responsible for about 70% of Confirmed Cases.
Diabetes Mellitus, Type 2
A family with novel homozygous deletion mutation (c.1255delT; p.Phe419Serfs*12) in the glucokinase gene, which is a rare cause of permanent neonatal diabetes mellitus.
Diabetes Mellitus, Type 2
A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q.
Diabetes Mellitus, Type 2
A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.
Diabetes Mellitus, Type 2
A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes.
Diabetes Mellitus, Type 2
A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
A missense mutation, Val62Ala, in the glucokinase gene in a Norwegian family with maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
A new clinical screening strategy and prevalence estimation for glucokinase variant-induced diabetes in an adult Chinese population.
Diabetes Mellitus, Type 2
A new missense mutation in the glucokinase gene in an Italian Mody family.
Diabetes Mellitus, Type 2
A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.
Diabetes Mellitus, Type 2
A novel glucokinase gene mutation and its effect on glycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2.
Diabetes Mellitus, Type 2
A novel heterozygous mutation in the glucokinase gene is responsible for an early-onset mild form of maturity-onset diabetes of the young, type 2.
Diabetes Mellitus, Type 2
A novel mutation in exon 5 of the glucokinase gene in an Argentinian family with maturity onset diabetes of the young.
Diabetes Mellitus, Type 2
A Novel Mutation of the Glucokinase Gene in Maturity-onset Diabetes of the Young Type 2 (MODY2).
Diabetes Mellitus, Type 2
A novel Phe75fsdelT mutation in the hepatocyte nuclear factor-4alpha gene in a Danish pedigree with maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease.
Diabetes Mellitus, Type 2
A patent review of glucokinase activators and disruptors of the glucokinase--glucokinase regulatory protein interaction: 2011-2014.
Diabetes Mellitus, Type 2
A Pathophysiology of Type 2 Diabetes Unrelated to Metabolic Syndrome.
Diabetes Mellitus, Type 2
A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study).
Diabetes Mellitus, Type 2
A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis.
Diabetes Mellitus, Type 2
A review of maturity onset diabetes of the young (MODY) and challenges in the management of glucokinase-MODY.
Diabetes Mellitus, Type 2
A single dose of dapagliflozin, an SGLT-2 inhibitor, induces higher glycosuria in GCK- and HNF1A-MODY than in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.
Diabetes Mellitus, Type 2
Absence of Islet Autoantibodies and Modestly Raised Glucose Values at Diabetes Diagnosis Should Lead to Testing for MODY: Lessons From a 5-Year Pediatric Swedish National Cohort Study.
Diabetes Mellitus, Type 2
Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260.
Diabetes Mellitus, Type 2
Agonist: the case for insulin resistance as a necessary and sufficient cause of type II diabetes mellitus.
Diabetes Mellitus, Type 2
Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
Diabetes Mellitus, Type 2
AMG 151 (ARRY-403), a novel glucokinase activator, decreases fasting and postprandial glycaemia in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Analysis of the GCK gene in 79 MODY type 2 patients: A multicenter Turkish study, mutation profile and description of twenty novel mutations.
Diabetes Mellitus, Type 2
Analysis of the glucokinase gene in Mexican families displaying early-onset non-insulin-dependent diabetes mellitus including MODY families.
Diabetes Mellitus, Type 2
Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.
Diabetes Mellitus, Type 2
Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome.
Diabetes Mellitus, Type 2
Assessing the potential of glucokinase activators in diabetes therapy.
Diabetes Mellitus, Type 2
Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon model.
Diabetes Mellitus, Type 2
Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations.
Diabetes Mellitus, Type 2
Association between lncRNA and GCKR gene in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.
Diabetes Mellitus, Type 2
Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study.
Diabetes Mellitus, Type 2
ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.
Diabetes Mellitus, Type 2
Atypical phenotype associated with reported GCK exon 10 deletions: clinical judgement is needed alongside appropriate genetic investigations.
Diabetes Mellitus, Type 2
Author Correction: Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Beta cell function and insulin sensitivity in obese youth with maturity onset diabetes of youth mutations vs type 2 diabetes in TODAY: Longitudinal observations and glycemic failure.
Diabetes Mellitus, Type 2
beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.
Diabetes Mellitus, Type 2
beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.
Diabetes Mellitus, Type 2
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
Diabetes Mellitus, Type 2
Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.
Diabetes Mellitus, Type 2
Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.
Diabetes Mellitus, Type 2
Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice.
Diabetes Mellitus, Type 2
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.
Diabetes Mellitus, Type 2
CA-repeated microsatellite polymorphism of the glucokinase gene and its association with non-insulin-dependent diabetes mellitus in Taiwanese.
Diabetes Mellitus, Type 2
Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase.
Diabetes Mellitus, Type 2
Cardiovascular risk assessment by coronary artery calcium score in subjects with maturity-onset diabetes of the young caused by glucokinase mutations.
Diabetes Mellitus, Type 2
Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI).
Diabetes Mellitus, Type 2
Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.
Diabetes Mellitus, Type 2
Characterization of glucokinase polymorphisms associated with maturity-onset diabetes of the young (MODY2) in Jordanian population.
Diabetes Mellitus, Type 2
Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes.
Diabetes Mellitus, Type 2
Characterization of two MODY2 mutations with different susceptibility to activation.
Diabetes Mellitus, Type 2
Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes.
Diabetes Mellitus, Type 2
Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat.
Diabetes Mellitus, Type 2
Circulating ghrelin level is higher in HNF1A-MODY and GCK-MODY than in polygenic forms of diabetes mellitus.
Diabetes Mellitus, Type 2
Clinical characteristics of subjects with a missense mutation in glucokinase.
Diabetes Mellitus, Type 2
Clinical follow-up of two Brazilian subjects with glucokinase-MODY (MODY2) with description of a novel mutation.
Diabetes Mellitus, Type 2
Clinical implications of the glucokinase impaired function - GCK MODY today.
Diabetes Mellitus, Type 2
Clinically-Defined Maturity Onset Diabetes of the Young in Omanis: Absence of the common Caucasian gene mutations.
Diabetes Mellitus, Type 2
Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23.
Diabetes Mellitus, Type 2
Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.
Diabetes Mellitus, Type 2
Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
Diabetes Mellitus, Type 2
Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis.
Diabetes Mellitus, Type 2
Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.
Diabetes Mellitus, Type 2
Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment.
Diabetes Mellitus, Type 2
Complications of Diabetes: An Insight into Genetic Polymorphism and Role of Insulin.
Diabetes Mellitus, Type 2
Counterregulatory responses to hypoglycemia in patients with glucokinase gene mutations.
Diabetes Mellitus, Type 2
Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance.
Diabetes Mellitus, Type 2
Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Design, synthesis, and pharmacological evaluation of 2-(4-sulfonylphenyl)-2-[(E)-pyrrolidin-1-ylimino]-N-thiazoleacetamides as glucokinase activators.
Diabetes Mellitus, Type 2
Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators.
Diabetes Mellitus, Type 2
Detection of glucokinase gene defects in non-obese Japanese children diagnosed with diabetes by school medical examinations.
Diabetes Mellitus, Type 2
Determination of unbound fraction of dorzagliatin in human plasma by equilibrium dialysis and LC-MS/MS and its application to a clinical pharmacokinetic study.
Diabetes Mellitus, Type 2
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
Diabetes Mellitus, Type 2
Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q.
Diabetes Mellitus, Type 2
Diagnosis of maturity-onset diabetes of the young in the pediatric diabetes clinic.
Diabetes Mellitus, Type 2
Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.
Diabetes Mellitus, Type 2
Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus.
Diabetes Mellitus, Type 2
Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice.
Diabetes Mellitus, Type 2
Dipeptidyl peptidase-4 inhibitor anagliptin ameliorates diabetes in mice with haploinsufficiency of glucokinase on a high-fat diet.
Diabetes Mellitus, Type 2
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Discovery of a novel site regulating glucokinase activity following characterisation of a new mutation causing hyperinsulinaemic hypoglycaemia in humans.
Diabetes Mellitus, Type 2
Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Diabetes Mellitus, Type 2
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.
Diabetes Mellitus, Type 2
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia.
Diabetes Mellitus, Type 2
Discovery of piragliatin-first glucokinase activator studied in type 2 diabetic patients.
Diabetes Mellitus, Type 2
Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic ?-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection.
Diabetes Mellitus, Type 2
Dose-Dependent Effect of Piragliatin, a Glucokinase Activator, on the QT Interval Following Short-Term Multiple Doses in Patients With Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Dose-ranging study with the glucokinase activator AZD1656 as monotherapy in Japanese patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Dose-ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin.
Diabetes Mellitus, Type 2
Early gene-diet interaction between glucokinase regulatory protein (GCKR) polymorphism, vegetable and fish intakes in modulating triglyceride levels in healthy adolescents.
Diabetes Mellitus, Type 2
Early-onset type 2 (non-insulin-dependent) diabetes mellitus is associated with glucokinase locus, but not with adenosine deaminase locus, in the Japanese population.
Diabetes Mellitus, Type 2
Effect of exogenously administered glucagon versus spontaneous endogenous counter-regulation on glycaemic recovery from insulin-induced hypoglycaemia in patients with type 2 diabetes treated with a novel glucokinase activator, AZD1656, and metformin.
Diabetes Mellitus, Type 2
Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.
Diabetes Mellitus, Type 2
Effects of piragliatin, a glucokinase activator, on fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity.
Diabetes Mellitus, Type 2
Efficacy and safety of glucokinase activators for type 2 diabetes mellitus therapy: a meta-analysis of double-blind randomized controlled trials.
Diabetes Mellitus, Type 2
Essential role of glucokinase in the protection of pancreatic ? cells to the glucose energetic status.
Diabetes Mellitus, Type 2
Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes.
Diabetes Mellitus, Type 2
Evolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2).
Diabetes Mellitus, Type 2
Exploring the in vivo mechanisms of action of glucokinase activators in type 2 diabetes.
Diabetes Mellitus, Type 2
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
Diabetes Mellitus, Type 2
Four Cases of Maturity Onset Diabetes of the Young (MODY) Type 5 Associated with Mutations in the Hepatocyte Nuclear Factor 1 Beta (HNF1B) Gene Presenting in a 13-Year-Old Boy and in Adult Men Aged 33, 34, and 35 Years in Poland.
Diabetes Mellitus, Type 2
Four novel mutations, including the first gross deletion in TCF1, identified in HNF-4alpha, GCK and TCF1 in patients with MODY in Israel.
Diabetes Mellitus, Type 2
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.
Diabetes Mellitus, Type 2
Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children.
Diabetes Mellitus, Type 2
Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2.
Diabetes Mellitus, Type 2
G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY).
Diabetes Mellitus, Type 2
GCK monogenic diabetes and gestational diabetes: possible diagnosis on clinical grounds.
Diabetes Mellitus, Type 2
GCK Mutation in a Child with Maturity Onset Diabetes of the Young, Type 2.
Diabetes Mellitus, Type 2
GCK mutations in Chinese MODY2 patients: a family pedigree report and review of Chinese literature.
Diabetes Mellitus, Type 2
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
Diabetes Mellitus, Type 2
Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene.
Diabetes Mellitus, Type 2
Genetic analysis of glucokinase and the chromosome 20 diabetes susceptibility locus in families with type 2 diabetes.
Diabetes Mellitus, Type 2
Genetic and bioinformatics analysis of four novel GCK missense variants detected in Caucasian families with GCK-MODY phenotype.
Diabetes Mellitus, Type 2
Genetic and clinical characteristics of Korean maturity-onset diabetes of the young (MODY) patients.
Diabetes Mellitus, Type 2
Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patients.
Diabetes Mellitus, Type 2
Genetic causes of maturity onset diabetes of the young may be less prevalent in American pregnant women recently diagnosed with diabetes mellitus than in previously studied European populations.
Diabetes Mellitus, Type 2
Genetic determinants of type 2 diabetes mellitus: lessons learned from family studies.
Diabetes Mellitus, Type 2
Genetic polymorphism of glucokinase on the risk of type 2 diabetes and impaired glucose regulation: evidence based on 298, 468 subjects.
Diabetes Mellitus, Type 2
Genetic testing for glucokinase mutations in clinically selected patients with MODY: a worthwhile investment.
Diabetes Mellitus, Type 2
Genetic testing for maturity onset diabetes of the young in childhood hyperglycaemia.
Diabetes Mellitus, Type 2
Genetic testing of GCK-MODY identifies a novel pathogenic variant in a Chinese boy with early onset hyperglycemia.
Diabetes Mellitus, Type 2
Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives.
Diabetes Mellitus, Type 2
Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians.
Diabetes Mellitus, Type 2
Genomic analysis of five chromosome 7p deletion patients with Greig cephalopolysyndactyly syndrome (GCPS).
Diabetes Mellitus, Type 2
Genotype-phenotype Characteristics of Turkish Children with Glucokinase Mutations Associated Maturity-onset Diabetes in the Young.
Diabetes Mellitus, Type 2
Glucagon-like peptide-1 enhances glucokinase activity in pancreatic ?-cells through the association of Epac2 with Rim2 and Rab3A.
Diabetes Mellitus, Type 2
Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.
Diabetes Mellitus, Type 2
Glucokinase activation or inactivation: Which will lead to the treatment of type 2 diabetes?
Diabetes Mellitus, Type 2
Glucokinase activators for the potential treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Glucokinase Activators for Type 2 Diabetes: Challenges and Future Developments.
Diabetes Mellitus, Type 2
Glucokinase and the potential of glucokinase activation in type 2 diabetes.
Diabetes Mellitus, Type 2
Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations.
Diabetes Mellitus, Type 2
Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.
Diabetes Mellitus, Type 2
Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.
Diabetes Mellitus, Type 2
Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.
Diabetes Mellitus, Type 2
Glucokinase Gene Mutation Screening in Argentinean Clinically Characterized MODY Patients.
Diabetes Mellitus, Type 2
Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.
Diabetes Mellitus, Type 2
Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in a cohort of elderly Finnish men.
Diabetes Mellitus, Type 2
Glucokinase gene variants in Chinese subjects with the common form of NIDDM.
Diabetes Mellitus, Type 2
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.
Diabetes Mellitus, Type 2
Glucokinase gene variations in Japanese-Americans with a family history of NIDDM.
Diabetes Mellitus, Type 2
Glucokinase in stellate ganglia cooperates with P2X3 receptor to develop cardiac sympathetic neuropathy in type 2 diabetes rats.
Diabetes Mellitus, Type 2
Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing Beta-Cell Mass in db/db Mice.
Diabetes Mellitus, Type 2
Glucokinase MODY and implications for treatment goals of common forms of diabetes.
Diabetes Mellitus, Type 2
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
Diabetes Mellitus, Type 2
Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression.
Diabetes Mellitus, Type 2
Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats.
Diabetes Mellitus, Type 2
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Diabetes Mellitus, Type 2
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia.
Diabetes Mellitus, Type 2
Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.
Diabetes Mellitus, Type 2
Glycemic Effect and Safety of a Systemic, Partial Glucokinase Activator, PF-04937319, in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin-A Randomized, Crossover, Active-Controlled Study.
Diabetes Mellitus, Type 2
Haploinsufficiency at GCK gene is not a frequent event in MODY2 patients.
Diabetes Mellitus, Type 2
Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
Diabetes Mellitus, Type 2
Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians.
Diabetes Mellitus, Type 2
Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960.
Diabetes Mellitus, Type 2
Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes.
Diabetes Mellitus, Type 2
High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population.
Diabetes Mellitus, Type 2
High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP).
Diabetes Mellitus, Type 2
High-resolution electrospray ionization Fourier transform mass spectrometry with infrared multiphoton dissociation of glucokinase from Bacillus Stearothermophilus.
Diabetes Mellitus, Type 2
High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes.
Diabetes Mellitus, Type 2
Homotropic allosteric regulation in monomeric mammalian glucokinase.
Diabetes Mellitus, Type 2
Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.
Diabetes Mellitus, Type 2
Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism.
Diabetes Mellitus, Type 2
Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization.
Diabetes Mellitus, Type 2
Human hexokinase II: localization of the polymorphic gene to chromosome 2.
Diabetes Mellitus, Type 2
Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice.
Diabetes Mellitus, Type 2
Identification and analysis of novel R308K mutation in glucokinase of type 2 diabetic patient and its kinetic correlation.
Diabetes Mellitus, Type 2
Identification and functional characterisation of novel glucokinase mutations causing maturity-onset diabetes of the young in Slovakia.
Diabetes Mellitus, Type 2
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
Diabetes Mellitus, Type 2
Identification of 21 novel glucokinase (GCK) mutations in UK and European Caucasians with maturity-onset diabetes of the young (MODY).
Diabetes Mellitus, Type 2
Identification of eight novel glucokinase mutations in Italian children with maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus.
Diabetes Mellitus, Type 2
Identification of glucokinase mutations in subjects with gestational diabetes mellitus.
Diabetes Mellitus, Type 2
Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing.
Diabetes Mellitus, Type 2
Identification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients.
Diabetes Mellitus, Type 2
Identification of novel GCK and HNF1A/TCF1 mutations and polymorphisms in German families with maturity-onset diabetes of the young (MODY).
Diabetes Mellitus, Type 2
Identification of novel polymorphisms in the glucokinase and glucose-6-phosphatase genes in infants who died suddenly and unexpectedly.
Diabetes Mellitus, Type 2
Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes.
Diabetes Mellitus, Type 2
Identification of two new mutations in the glucokinase gene that result in maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Impact of Type 2 diabetes on Glucokinase diabetes (GCK-MODY) phenotype in a Roma (Gypsy) family - case report.
Diabetes Mellitus, Type 2
Impairment of glucokinase translocation in cultured hepatocytes from OLETF and GK rats, animal models of type 2 diabetes.
Diabetes Mellitus, Type 2
Importance of glucokinase -258G/A polymorphism in Asian Indians with post-transplant and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells.
Diabetes Mellitus, Type 2
Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism.
Diabetes Mellitus, Type 2
Incretin Effect and Glucagon Responses to Oral and Intravenous Glucose in Patients with Maturity Onset Diabetes of the Young - Type 2 and Type 3.
Diabetes Mellitus, Type 2
Incretin hormones and maturity onset diabetes of the young--pathophysiological implications and anti-diabetic treatment potential.
Diabetes Mellitus, Type 2
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.
Diabetes Mellitus, Type 2
Interindividual variations in metabolism and pharmacokinetics of 3-(6-methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a glucokinase activator, in rats caused by the genetic polymorphism of CYP2D1.
Diabetes Mellitus, Type 2
Intima-media thickness and endothelial dysfunction in GCK and HNF1A-MODY patients.
Diabetes Mellitus, Type 2
Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
iPSC-derived ? cells model diabetes due to glucokinase deficiency.
Diabetes Mellitus, Type 2
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic ?-cells.
Diabetes Mellitus, Type 2
Lack of Potential Pharmacokinetic and Pharmacodynamic Interactions Between Piragliatin, a Glucokinase Activator, and Simvastatin in Patients With Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Lessons from glucokinase activators: the problem of declining efficacy.
Diabetes Mellitus, Type 2
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research.
Diabetes Mellitus, Type 2
Linkage analysis and molecular scanning of glucokinase gene in NIDDM families.
Diabetes Mellitus, Type 2
Linkage analysis does not support a role for glucokinase gene in the aetiology of type 2 diabetes mellitus among north western Italians.
Diabetes Mellitus, Type 2
Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2.
Diabetes Mellitus, Type 2
Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees.
Diabetes Mellitus, Type 2
Linkage analysis of the genetic markers of the candidate genes with non-insulin dependent diabetes mellitus in Chinese families.
Diabetes Mellitus, Type 2
Linkage analysis of the glucokinase locus in familial type 2 (non-insulin-dependent) diabetic pedigrees.
Diabetes Mellitus, Type 2
Linkage of maturity-onset diabetes of the young to the glucokinase gene--evidence of genetic heterogeneity.
Diabetes Mellitus, Type 2
LncRNA NONRATT021972 siRNA normalized the dysfunction of hepatic glucokinase through AKT signaling in T2DM rats.
Diabetes Mellitus, Type 2
Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).
Diabetes Mellitus, Type 2
Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2.
Diabetes Mellitus, Type 2
Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population.
Diabetes Mellitus, Type 2
Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.
Diabetes Mellitus, Type 2
Maturity Onset Diabetes of the Young due to Glucokinase, HNF1-A, HNF1-B, and HNF4-A Mutations in a Cohort of Turkish Children Diagnosed as Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Maturity Onset Diabetes of the Young is Not Necessarily Associated with Autosomal Inheritance: Case Description of a De Novo HFN1A Mutation.
Diabetes Mellitus, Type 2
Maturity onset diabetes of the young type 2 (MODY2): Insight from an extended family.
Diabetes Mellitus, Type 2
Maturity-onset diabetes of the young (MODY) in Brazil: Establishment of a national registry and appraisal of available genetic and clinical data.
Diabetes Mellitus, Type 2
Maturity-onset diabetes of the young (MODY): a new challenge for pediatric diabetologists.
Diabetes Mellitus, Type 2
Maturity-onset diabetes of the young (MODY): current perspectives on diagnosis and treatment.
Diabetes Mellitus, Type 2
Maturity-Onset Diabetes of the Young (MODY): Making the Right Diagnosis to Optimize Treatment.
Diabetes Mellitus, Type 2
Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity.
Diabetes Mellitus, Type 2
Maturity-onset diabetes of the young: Different diabetes in an infant with cystic fibrosis.
Diabetes Mellitus, Type 2
Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization.
Diabetes Mellitus, Type 2
Medicinal Chemistry Approaches for Glucokinase Activation to Treat Type 2 Diabetes.
Diabetes Mellitus, Type 2
Metabolic diseases drug discovery world summit. July 28-29, 2003, San Diego, CA, USA.
Diabetes Mellitus, Type 2
Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers.
Diabetes Mellitus, Type 2
Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2).
Diabetes Mellitus, Type 2
Microsatellite polymorphisms at the glucokinase locus: a population association study in Caucasian type 2 diabetic subjects.
Diabetes Mellitus, Type 2
Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.
Diabetes Mellitus, Type 2
Minigene splicing assessment of 20 novel synonymous and intronic glucokinase gene variants identified in patients with maturity onset diabetes of the young.
Diabetes Mellitus, Type 2
Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.
Diabetes Mellitus, Type 2
Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit.
Diabetes Mellitus, Type 2
Mitochondrial diabetes: molecular mechanisms and clinical presentation.
Diabetes Mellitus, Type 2
Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?
Diabetes Mellitus, Type 2
MODY 2: mutation identification and molecular ancestry in a Brazilian family.
Diabetes Mellitus, Type 2
Molecular and clinical characterization of glucokinase maturity-onset diabetes of the young (GCK-MODY) in Japanese patients.
Diabetes Mellitus, Type 2
Molecular changes in the Glucokinase gene (GCK) associated with the diagnosis of Maturity Onset Diabetes of the Young (MODY) in pregnant women and newborns.
Diabetes Mellitus, Type 2
Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times.
Diabetes Mellitus, Type 2
Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.
Diabetes Mellitus, Type 2
Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B.
Diabetes Mellitus, Type 2
Molecular screening of the glucokinase gene in familial type 2 (non-insulin-dependent) diabetes mellitus.
Diabetes Mellitus, Type 2
Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes.
Diabetes Mellitus, Type 2
Monogenic disorders of the pancreatic ?-cell: personalizing treatment for rare forms of diabetes and hypoglycemia.
Diabetes Mellitus, Type 2
Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis.
Diabetes Mellitus, Type 2
Mutation screening in 18 Caucasian families suggest the existence of other MODY genes.
Diabetes Mellitus, Type 2
Mutations in exons 10 and 11 of human Glucokinase results in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients.
Diabetes Mellitus, Type 2
Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile.
Diabetes Mellitus, Type 2
Mutations in MODY genes are not common cause of early-onset type 2 diabetes in Mexican families.
Diabetes Mellitus, Type 2
Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus.
Diabetes Mellitus, Type 2
Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetes Mellitus, Type 2
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
Diabetes Mellitus, Type 2
NAPDH oxidase mediates glucolipotoxicity-induced beta cell dysfunction - Clinical implications.
Diabetes Mellitus, Type 2
NIDDM--genetic marker; glucose transporter, glucokinase, and mitochondria gene.
Diabetes Mellitus, Type 2
Nine novel mutations in maturity-onset diabetes of the young (MODY) candidate genes in 22 Spanish families.
Diabetes Mellitus, Type 2
Nonradioactive screening of glucokinase mutations in maturity onset diabetes of the young.
Diabetes Mellitus, Type 2
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Novel glucokinase gene mutation in the first Macedonian family tested for MODY.
Diabetes Mellitus, Type 2
Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population.
Diabetes Mellitus, Type 2
Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q.
Diabetes Mellitus, Type 2
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Nuclear magnetic resonance studies of hepatic glucose metabolism in humans.
Diabetes Mellitus, Type 2
Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.
Diabetes Mellitus, Type 2
Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.
Diabetes Mellitus, Type 2
Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy.
Diabetes Mellitus, Type 2
Pathogenicity of a glucokinase gene mutation and description of its clinical phenotype.
Diabetes Mellitus, Type 2
Pharmacokinetic and Pharmacodynamic Drug Interaction Study of Piragliatin, a Glucokinase Activator, and Glyburide, a Sulfonylurea, in Type 2 Diabetic Patients.
Diabetes Mellitus, Type 2
Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs.
Diabetes Mellitus, Type 2
Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).
Diabetes Mellitus, Type 2
Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study.
Diabetes Mellitus, Type 2
Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese.
Diabetes Mellitus, Type 2
Polymorphism of glucokinase gene in non-insulin dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Polymorphisms in genes involved in glucose metabolism in cases of sudden infant death syndrome.
Diabetes Mellitus, Type 2
Polymorphisms rs144723656, rs2268574, and rs2268575 of the glucokinase gene are not associated with obese women with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians.
Diabetes Mellitus, Type 2
Precision Therapy for a Chinese Family With Maturity-Onset Diabetes of the Young.
Diabetes Mellitus, Type 2
Preliminary screening of mutations in the glucokinase gene of Chinese patients with gestational diabetes.
Diabetes Mellitus, Type 2
Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia.
Diabetes Mellitus, Type 2
Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth.
Diabetes Mellitus, Type 2
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.
Diabetes Mellitus, Type 2
Promoter variation in the liver glucokinase is a risk factor for non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Property-based design in the optimisation of benzamide glucokinase activators: from hit to clinic.
Diabetes Mellitus, Type 2
Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Diabetes Mellitus, Type 2
Recent advances in glucokinase activators for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Recent clinical advances of glucokinase activators in the treatment of diabetes mellitus type 2.
Diabetes Mellitus, Type 2
Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics.
Diabetes Mellitus, Type 2
Recent Updates on Glucokinase Activators and Glucokinase Regulatory Protein Disrupters for the Treatment of Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Recent updates on glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Repair of diverse diabetic defects of ?-cells in man and mouse by pharmacological glucokinase activation.
Diabetes Mellitus, Type 2
Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin.
Diabetes Mellitus, Type 2
Safety, pharmacokinetics and pharmacodynamics of multiple-ascending doses of the novel glucokinase activator AZD1656 in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Safety, Pharmacokinetics, and Pharmacodynamics of Globalagliatin, a Glucokinase Activator, in Chinese Patients with Type 2 Diabetes Mellitus: A Randomized, Phase Ib, 28-day Ascending Dose Study.
Diabetes Mellitus, Type 2
Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study.
Diabetes Mellitus, Type 2
Screening of mutations and polymorphisms in the glucokinase gene in Czech diabetic and healthy control populations.
Diabetes Mellitus, Type 2
Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients.
Diabetes Mellitus, Type 2
Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes.
Diabetes Mellitus, Type 2
Searching for Maturity-Onset Diabetes of the Young (MODY): When and What for?
Diabetes Mellitus, Type 2
Sequence variations of the glucokinase gene in Japanese subjects with NIDDM.
Diabetes Mellitus, Type 2
Single-strand conformation polymorphism analysis of the glucose transporter gene GLUT1 in maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique.
Diabetes Mellitus, Type 2
Small molecular glucokinase activators: Has another new anti-diabetic therapeutic lost favour.
Diabetes Mellitus, Type 2
Small molecule glucokinase activators as glucose lowering agents: a new paradigm for diabetes therapy.
Diabetes Mellitus, Type 2
Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans.
Diabetes Mellitus, Type 2
Specific insulin and proinsulin secretion in glucokinase-deficient individuals.
Diabetes Mellitus, Type 2
Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.
Diabetes Mellitus, Type 2
Strategies for the design of hepatoselective glucokinase activators to treat type 2 diabetes.
Diabetes Mellitus, Type 2
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.
Diabetes Mellitus, Type 2
Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).
Diabetes Mellitus, Type 2
Structure based design, synthesis and biological evaluation of amino phosphonate derivatives as human glucokinase activators.
Diabetes Mellitus, Type 2
Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Targeting hepatic glucokinase in type 2 diabetes: weighing the benefits and risks.
Diabetes Mellitus, Type 2
Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator.
Diabetes Mellitus, Type 2
The 0.1% of the Population With Glucokinase Monogenic Diabetes Can be Recognized by Clinical Characteristics in Pregnancy: The Atlantic Diabetes in Pregnancy Cohort.
Diabetes Mellitus, Type 2
The APOE?3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis.
Diabetes Mellitus, Type 2
The clinical management of hyperglycemia in pregnancy complicated by maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
The effects and safety of activators of glucokinase versus placebo in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.
Diabetes Mellitus, Type 2
The genetic abnormality in the beta cell determines the response to an oral glucose load.
Diabetes Mellitus, Type 2
The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food.
Diabetes Mellitus, Type 2
The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent.
Diabetes Mellitus, Type 2
The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells.
Diabetes Mellitus, Type 2
The influence of dietary carbohydrate content on glycaemia in patients with glucokinase maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
The potential role of glucokinase activator SHP289-04 in anti-diabetes and hepatic protection.
Diabetes Mellitus, Type 2
The prevalence of monogenic diabetes in Australia: the Fremantle Diabetes Study Phase II.
Diabetes Mellitus, Type 2
The Relationship of Glucokinase Activator-induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies.
Diabetes Mellitus, Type 2
The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte.
Diabetes Mellitus, Type 2
Therapy targeting beta-cell survival and function in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online.
Diabetes Mellitus, Type 2
Tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator AZD1656, after single ascending doses in healthy subjects during euglycemic clamp.
Diabetes Mellitus, Type 2
Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.
Diabetes Mellitus, Type 2
TTP399: an investigational liver-selective glucokinase (GK) activator as a potential treatment for type 2 diabetes.
Diabetes Mellitus, Type 2
Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes.
Diabetes Mellitus, Type 2
Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus.
Diabetes Mellitus, Type 2
Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family.
Diabetes Mellitus, Type 2
Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity.
Diabetes Mellitus, Type 2
Update on clinical screening of maturity-onset diabetes of the young (MODY).
Diabetes Mellitus, Type 2
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.
Diabetes Mellitus, Type 2
Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.
Diabetes Mellitus, Type 2
Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.
Diabetes Mellitus, Type 2
Variant forms of glucokinase gene in Japanese patients with late-onset type 2 diabetes.
Diabetes Mellitus, Type 2
[A novel mutation W257R in GCK gene discovered from a Chinese patient with maturity onset diabetes of the young].
Diabetes Mellitus, Type 2
[A three-year follow-up observation of a pedigree of maturity onset diabetes of the young caused by a novel mutation of glucokinase and literature review].
Diabetes Mellitus, Type 2
[Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs].
Diabetes Mellitus, Type 2
[Current treatment options in Maturity-Onset Diabetes of the Young].
Diabetes Mellitus, Type 2
[Diabetes mellitus caused by a mutation of glucokinase gene. Report of an affected family].
Diabetes Mellitus, Type 2
[Effects of berberine on expression of hepatocyte nuclear factor 4alpha and glucokinase activity in mouse primary hepatocytes]
Diabetes Mellitus, Type 2
[Genetics of type 2 diabetes mellitus: genes implicated in early onset diabetes]
Diabetes Mellitus, Type 2
[Glucokinase gene abnormalities in maturity-onset diabetes of the young (MODY) and late-onset NIDDM]
Diabetes Mellitus, Type 2
[Glucokinase gene mutation as a causative factor of permanent neonatal diabetes mellitus].
Diabetes Mellitus, Type 2
[Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery]
Diabetes Mellitus, Type 2
[Heterogeneity in pathogenesis of NIDDM and recent advances in research of diabetogenic genes]
Diabetes Mellitus, Type 2
[Maturity onset diabetes of the young (MODY)-screening, diagnostic and therapy].
Diabetes Mellitus, Type 2
[Maturity-onset diabetes of the young--MODY. Molecular-genetic, pathophysiological and clinical characteristics]
Diabetes Mellitus, Type 2
[MODY, a model of genotype/phenotype interactions in type 2 diabetes]
Diabetes Mellitus, Type 2
[Mutation of GCK gene of Chinese patients with late-onset type 2 diabetes]
Diabetes Mellitus, Type 2
[New aspects of pancreatic beta cell functions and their possible therapeutic applications]
Diabetes Mellitus, Type 2
[Novel glucokinase mutation in a boy with maturity-onset diabetes of the young]
Diabetes, Gestational
A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus.
Diabetes, Gestational
A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria.
Diabetes, Gestational
Association of the glucokinase gene promoter polymorphism -30G > A (rs1799884) with gestational diabetes mellitus susceptibility: a case-control study and meta-analysis.
Diabetes, Gestational
Comment on Rudland et al. Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c. Diabetes Care 2016;39:50-52.
Diabetes, Gestational
Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus.
Diabetes, Gestational
GCK monogenic diabetes and gestational diabetes: possible diagnosis on clinical grounds.
Diabetes, Gestational
Genetic causes of maturity onset diabetes of the young may be less prevalent in American pregnant women recently diagnosed with diabetes mellitus than in previously studied European populations.
Diabetes, Gestational
Gestational diabetes mellitus and gene mutations which affect insulin secretion.
Diabetes, Gestational
Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.
Diabetes, Gestational
Glucokinase mutations in a phenotypically selected multiethnic group of women with a history of gestational diabetes.
Diabetes, Gestational
High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population.
Diabetes, Gestational
Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women.
Diabetes, Gestational
Identification of glucokinase mutations in subjects with gestational diabetes mellitus.
Diabetes, Gestational
Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c.
Diabetes, Gestational
Influence of maternal and fetal glucokinase mutations in gestational diabetes.
Diabetes, Gestational
Linkage analysis and molecular scanning of glucokinase gene in NIDDM families.
Diabetes, Gestational
MiR-330-3p contributes to INS-1 cell dysfunction by targeting glucokinase in gestational diabetes mellitus.
Diabetes, Gestational
Monogenic diabetes caused by GCK gene mutation is misdiagnosed as gestational diabetes - A multicenter study in Portugal.
Diabetes, Gestational
Preliminary screening of mutations in the glucokinase gene of Chinese patients with gestational diabetes.
Diabetes, Gestational
The 0.1% of the Population With Glucokinase Monogenic Diabetes Can be Recognized by Clinical Characteristics in Pregnancy: The Atlantic Diabetes in Pregnancy Cohort.
Diabetes, Gestational
The association of the glucokinase rs4607517 polymorphism with gestational diabetes mellitus and its interaction with sweets consumption in Chinese women.
Diabetes, Gestational
The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes.
Diabetes, Gestational
The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent.
Diabetes, Gestational
The polymorphism rs2268574 in Glucokinase gene is associated with gestational Diabetes mellitus.
Diabetes, Gestational
Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online.
Diabetes, Gestational
[Association of glucokinase gene with gestational diabetes mellitus in Chinese]
Diabetes, Gestational
[Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery]
Diabetic Cardiomyopathies
Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.
Diabetic Neuropathies
NONRATT021972 long-noncoding RNA: A promising lncRNA in diabetes-related diseases.
Dyslipidemias
A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies.
Dyslipidemias
Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.
Dyslipidemias
Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study.
Dyslipidemias
The APOE?3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis.
Fatty Liver
Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.
Fatty Liver
Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.
Fatty Liver
Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography.
Fatty Liver
Correction: glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Fatty Liver
Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Fatty Liver
Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans.
Fatty Liver
Non-alcoholic fatty liver disease concerns with glucokinase activators - Authors' reply.
Fatty Liver
Pediatric non-alcoholic fatty liver disease: New insights and future directions.
Fatty Liver
Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans.
Fatty Liver
Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator.
Fatty Liver
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.
Fetal Growth Retardation
Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.
Fetal Growth Retardation
The effect of intrauterine growth restriction upon fetal and postnatal hepatic glucose transporter and glucokinase proteins.
Genetic Diseases, Inborn
Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.
Genetic Diseases, Inborn
Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY.
Genetic Diseases, Inborn
Therapy targeting beta-cell survival and function in type 2 diabetes mellitus.
glucokinase deficiency
ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.
glucokinase deficiency
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
glucokinase deficiency
Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age.
glucokinase deficiency
Clinical characteristics of mutation carriers in a large family with glucokinase diabetes (MODY2).
glucokinase deficiency
Complete glucokinase deficiency is not a common cause of permanent neonatal diabetes.
glucokinase deficiency
Evolution of hepatic glucose metabolism: liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR).
glucokinase deficiency
Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes.
glucokinase deficiency
Glucokinase deficiency results in a beta-cell disorder characterised by normal fasting plasma proinsulin concentrations.
glucokinase deficiency
Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation.
glucokinase deficiency
Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice.
glucokinase deficiency
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
glucokinase deficiency
iPSC-derived ? cells model diabetes due to glucokinase deficiency.
glucokinase deficiency
Neonatal diabetes mellitus due to complete glucokinase deficiency.
glucokinase deficiency
Permanent neonatal diabetes caused by a homozygous nonsense mutation in the glucokinase gene.
glucokinase deficiency
Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.
glucokinase deficiency
Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique.
Glucose Intolerance
A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men.
Glucose Intolerance
Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase.
Glucose Intolerance
Alterations in key carbohydrate-metabolizing enzyme activities in rat livers following bile duct ligation and its release.
Glucose Intolerance
Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivo.
Glucose Intolerance
Control of liver glucokinase activity: A potential new target for incretin hormones?
Glucose Intolerance
Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the young.
Glucose Intolerance
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
Glucose Intolerance
Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.
Glucose Intolerance
F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck.
Glucose Intolerance
Fetal programming of perivenous glucose uptake reveals a regulatory mechanism governing hepatic glucose output during refeeding.
Glucose Intolerance
Glucokinase activation or inactivation: Which will lead to the treatment of type 2 diabetes?
Glucose Intolerance
Glucokinase gene expression is nutritionally regulated in liver of gilthead sea bream (Sparus aurata).
Glucose Intolerance
Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.
Glucose Intolerance
Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in a cohort of elderly Finnish men.
Glucose Intolerance
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.
Glucose Intolerance
Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing Beta-Cell Mass in db/db Mice.
Glucose Intolerance
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Glucose Intolerance
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
Glucose Intolerance
Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism.
Glucose Intolerance
More severe impairment of oral than intravenous glucose tolerance in rats after eating a high fat diet.
Glucose Intolerance
NIDDM--genetic marker; glucose transporter, glucokinase, and mitochondria gene.
Glucose Intolerance
Pioglitazone versus metformin in two rat models of glucose intolerance and diabetes.
Glucose Intolerance
Positive association in the absence of linkage suggests a minor role for the glucokinase gene in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus amongst south Indians.
Glucose Intolerance
Production of a mouse strain with impaired glucose tolerance by systemic heterozygous knockout of the glucokinase gene and its feasibility as a prediabetes model.
Glucose Intolerance
Role of pregnane X receptor in obesity and glucose homeostasis in male mice.
Glucose Intolerance
Roles of hepatic glucokinase in intertissue metabolic communication: Examination of novel liver-specific glucokinase knockout mice.
Glucose Intolerance
Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online.
Glucose Intolerance
[Insulin-dependent neonatal and infant diabetes: genetics and physiopathology]
glycerol-3-phosphate dehydrogenase deficiency
The beta cell in NIDDM: giving light to the blind.
Glycosuria
Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of glucokinase in the liver.
Glycosuria
Neonatal islet cell transplantation in the diabetic rat: effect on hepatic enzyme activity and glucose homeostasis.
Hypercholesterolemia
Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model.
Hyperglycemia
A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.
Hyperglycemia
A glucokinase-like enzyme carries out glucose phosphorylation in capillaries of normal and spontaneously hyperglycemic rabbits.
Hyperglycemia
A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.
Hyperglycemia
Abnormal regulation of hepatic glucose output in maturity-onset diabetes of the young caused by a specific mutation of the glucokinase gene.
Hyperglycemia
Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.
Hyperglycemia
Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice.
Hyperglycemia
Antenatal Diagnosis of Fetal Genotype Determines if Maternal Hyperglycemia Due to a Glucokinase Mutation Requires Treatment.
Hyperglycemia
Autoregulation by glucose of hepatic glucose balance: permissive effect of insulin.
Hyperglycemia
Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.
Hyperglycemia
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
Hyperglycemia
Biochemical Characterization of MODY2 Glucokinase Variants V62M and G72R Reveals Reduced Enzymatic Activities Relative to Wild-type.
Hyperglycemia
Cardiovascular risk assessment by coronary artery calcium score in subjects with maturity-onset diabetes of the young caused by glucokinase mutations.
Hyperglycemia
Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness.
Hyperglycemia
Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes.
Hyperglycemia
Comment on: Chakera et al. Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment. Diabetes Care 2012;35:1832-1834.
Hyperglycemia
Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.
Hyperglycemia
Dexamethasone increases glucose cycling, but not glucose production, in healthy subjects.
Hyperglycemia
Differential Effect of LPS on Glucose, Lactate and Inflammatory Markers in the Lungs of Normal and Diabetic Mice.
Hyperglycemia
Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice.
Hyperglycemia
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Hyperglycemia
Energy-dependent intracellular translocation of glucokinase in rat pancreatic islets.
Hyperglycemia
Expression of glucokinase in skeletal muscle: a new approach to counteract diabetic hyperglycemia.
Hyperglycemia
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
Hyperglycemia
GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation.
Hyperglycemia
GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.
Hyperglycemia
Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2.
Hyperglycemia
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.
Hyperglycemia
Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.
Hyperglycemia
Glucokinase deficit and birthweight: does maternal hyperglycemia always meet fetal needs?
Hyperglycemia
Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation.
Hyperglycemia
Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake.
Hyperglycemia
Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase.
Hyperglycemia
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia.
Hyperglycemia
Glucose-regulated glucose uptake by transplanted muscle cells expressing glucokinase counteracts diabetic hyperglycemia.
Hyperglycemia
Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression.
Hyperglycemia
Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding.
Hyperglycemia
Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice.
Hyperglycemia
Hypoglycemic and antioxidative effects of hydroxyethyl methylcellulose in mice fed with high fat diet.
Hyperglycemia
Impact of Type 2 diabetes on Glucokinase diabetes (GCK-MODY) phenotype in a Roma (Gypsy) family - case report.
Hyperglycemia
In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.
Hyperglycemia
Influence of maternal and fetal glucokinase mutations in gestational diabetes.
Hyperglycemia
Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.
Hyperglycemia
Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research.
Hyperglycemia
Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.
Hyperglycemia
Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs.
Hyperglycemia
Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).
Hyperglycemia
Low glucokinase activity and high rates of gluconeogenesis contribute to hyperglycemia in barn owls (Tyto alba) after a glucose challenge.
Hyperglycemia
Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.
Hyperglycemia
Metabolism and fatty acid profile in fat and lean rainbow trout lines fed with vegetable oil: effect of carbohydrates.
Hyperglycemia
Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.
Hyperglycemia
Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes.
Hyperglycemia
Molecular changes in the Glucokinase gene (GCK) associated with the diagnosis of Maturity Onset Diabetes of the Young (MODY) in pregnant women and newborns.
Hyperglycemia
Mutations in exons 10 and 11 of human Glucokinase results in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients.
Hyperglycemia
Noninvasive Fetal Genotyping by Droplet Digital PCR to Identify Maternally Inherited Monogenic Diabetes Variants.
Hyperglycemia
Normal Glucose Metabolism in Carnivores Overlaps with Diabetes Pathology in Non-Carnivores.
Hyperglycemia
P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats.
Hyperglycemia
Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain.
Hyperglycemia
Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.
Hyperglycemia
Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs.
Hyperglycemia
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Hyperglycemia
Precision medicine in diabetes: A non-invasive prenatal diagnostic test for the determination of fetal glucokinase mutations.
Hyperglycemia
Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia.
Hyperglycemia
Rabbit lens and retina phosphorylate glucose through a glucokinase-like enzyme: study in normal and spontaneously hyperglycemic animals.
Hyperglycemia
Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase Mutation.
Hyperglycemia
Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus.
Hyperglycemia
Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets.
Hyperglycemia
Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.
Hyperglycemia
Response to Comment on: Chakera et al. Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment. Diabetes Care 2012;35:1832-1834.
Hyperglycemia
Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.
Hyperglycemia
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.
Hyperglycemia
Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.
Hyperglycemia
Should the Clinical Criteria for Suspecting Glucokinase Mutation-Related Hyperglycemia (MODY-2) Be Revisited During Pregnancy?
Hyperglycemia
Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique.
Hyperglycemia
Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.
Hyperglycemia
The clinical management of hyperglycemia in pregnancy complicated by maturity-onset diabetes of the young.
Hyperglycemia
The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent.
Hyperglycemia
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.
Hyperglycemia
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.
Hyperglycemia
The role of hepatic, renal and intestinal gluconeogenic enzymes in glucose homeostasis of juvenile rainbow trout.
Hyperglycemia
TMG-123, a novel glucokinase activator, exerts durable effects on hyperglycemia without increasing triglyceride in diabetic animal models.
Hyperglycemia
Translocation of glucokinase in pancreatic beta-cells during acute and chronic hyperglycemia.
Hyperglycemia
Treatment of Diabetes and Long-term Survival Following Insulin and Glucokinase Gene Therapy.
Hyperglycemia
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.
Hyperglycemia
Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats.
Hyperglycemia
Zhenqing recipe improves glucose metabolism and insulin sensitivity by repressing hepatic FOXO1 in type 2 diabetic rats.
Hyperinsulinism
A glucokinase gene mutation in a young boy with diabetes mellitus, hyperinsulinemia, and insulin resistance.
Hyperinsulinism
beta-cell stimulus - secretion coupling defects in rodent models of obesity.
Hyperinsulinism
Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.
Hyperinsulinism
Control of liver glucokinase activity: A potential new target for incretin hormones?
Hyperinsulinism
Derangement in hepatic enzymes caused by sucrose-drinking and its implication for the development of hyperglycemia in female Wistar fatty rats.
Hyperinsulinism
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Hyperinsulinism
Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice.
Hyperinsulinism
Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism due to glucokinase activating mutations.
Hyperinsulinism
Familial adult onset hyperinsulinism due to an activating glucokinase mutation: implications for pharmacological glucokinase activation.
Hyperinsulinism
Family with autosomal dominant hyperinsulinism associated with A456V mutation in the glucokinase gene.
Hyperinsulinism
Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.
Hyperinsulinism
Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake.
Hyperinsulinism
Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding.
Hyperinsulinism
Heterogeneity in phenotype of hyperinsulinism caused by activating glucokinase mutations: a novel mutation and its functional characterization.
Hyperinsulinism
Impact of insulin and glucocorticoid signalling on hepatic glucose homeostasis in the rat exposed to high-fructose diet and chronic stress.
Hyperinsulinism
In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues.
Hyperinsulinism
Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells.
Hyperinsulinism
Monogenic hyperinsulinemic hypoglycemia: current insights into the pathogenesis and management.
Hyperinsulinism
Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs.
Hyperinsulinism
Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.
Hyperinsulinism
Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle?
Hyperinsulinism
The effects of pregnancy steroids on adaptation of beta cells to pregnancy involve the pancreatic glucose sensor glucokinase.
Hyperlipidemias
Hyperlipemia in the gerbil: effect of diet on serum lipids and hepatic glucokinase.
Hyperlipidemias
Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
Hypersensitivity
Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene.
Hypersensitivity
Changes induced by sucrose administration on glucose metabolism in pancreatic islets in normal hamsters.
Hypersensitivity
Induction of the glucokinase gene by insulin in cultured neonatal rat hepatocytes. Relationship with DNase-I hypersensitive sites and functional analysis of a putative insulin-response element.
Hypertension
G/A Polymorphism at -258 of the Hepatic Glucokinase Promoter Is Not Associated with Decreased Birth Weight in Preterm Neonates.
Hyperthyroidism
Effect of different thyroid states on rat liver glucokinase synthesis and degradation in vivo.
Hyperthyroidism
Response of hepatic glucokinase and glucose-6-phosphatase activities in juvenile and adult hyperthyroid mice.
Hypertriglyceridemia
A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies.
Hypertriglyceridemia
Control of liver glucokinase activity: A potential new target for incretin hormones?
Hypertriglyceridemia
Impaired beta-cell function and deposition of fat droplets in the pancreas as a consequence of hypertriglyceridemia in OLETF rat, a model of spontaneous NIDDM.
Hypertriglyceridemia
Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families.
Hypertriglyceridemia
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.
Hypertriglyceridemia
Variants of Lipid-Related Genes in Adult Japanese Patients with Severe Hypertriglyceridemia.
Hypoglycemia
A novel glucokinase activator TMG-123 causes long-lasting hypoglycemia and impairs spermatogenesis irreversibly in rats.
Hypoglycemia
Adaptation of glucokinase gene expression in the rat dorsal vagal complex in a model for recurrent intermediate insulin-induced hypoglycemia: impact of gender.
Hypoglycemia
Conformational transition pathway in the activation process of allosteric glucokinase.
Hypoglycemia
Conformational transition pathway in the allosteric process of human glucokinase.
Hypoglycemia
Counterregulatory responses to hypoglycemia in patients with glucokinase gene mutations.
Hypoglycemia
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Hypoglycemia
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia.
Hypoglycemia
Dose selection using a semi-mechanistic integrated glucose-insulin-glucagon model: designing phase 2 trials for a novel oral glucokinase activator.
Hypoglycemia
Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol.
Hypoglycemia
Effects of caudal hindbrain lactate infusion on insulin-induced hypoglycemia and neuronal substrate transporter glucokinase and sulfonylurea receptor-1 gene expression in the ovariectomized female rat dorsal vagal complex: Impact of estradiol.
Hypoglycemia
Evidence-based tailoring of bioinformatics approaches to optimize methods that predict the effects of nonsynonymous amino acid substitutions in glucokinase.
Hypoglycemia
Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism due to glucokinase activating mutations.
Hypoglycemia
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
Hypoglycemia
Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.
Hypoglycemia
Glucokinase activation induces potent hypoglycemia without recruiting insulin and inhibits food intake in chicken.
Hypoglycemia
Glucokinase Activators AZD6370 and AZD1656 Do Not Affect the Central Counterregulatory Response to Hypoglycemia in Healthy Males.
Hypoglycemia
Glucokinase mutation-a rare cause of recurrent hypoglycemia in adults: a case report and literature review.
Hypoglycemia
Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression.
Hypoglycemia
Glycemic Effect and Safety of a Systemic, Partial Glucokinase Activator, PF-04937319, in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin-A Randomized, Crossover, Active-Controlled Study.
Hypoglycemia
Hyperinsulinemic hypoglycemia subtype glucokinase V91L mutant induces necrosis in ?-cells via ATP depletion.
Hypoglycemia
Hyperinsulinemic hypoglycemia without insulinoma: Think of activating glucokinase mutation.
Hypoglycemia
Hypoglycemic potential of current and emerging pharmacotherapies in type 2 diabetes mellitus.
Hypoglycemia
Impact of recurring intermediate insulin-induced hypoglycemia on hypothalamic paraventricular corticotropin-releasing hormone, oxytocin, vasopressin and glucokinase gene profiles: role of type II glucocorticoid receptors.
Hypoglycemia
Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
Hypoglycemia
Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.
Hypoglycemia
Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.
Hypoglycemia
Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.
Hypoglycemia
Quantitative RT-PCR and immunoblot analyses reveal acclimated A2 noradrenergic neuron substrate fuel transporter, glucokinase, phospho-AMPK, and dopamine-?-hydroxylase responses to hypoglycemia.
Hypoglycemia
Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.
Hypoglycemia
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
Hypoglycemia
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
Hypoglycemia
Strategies for the design of hepatoselective glucokinase activators to treat type 2 diabetes.
Hypoglycemia
Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.
Hypoglycemia
SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity.
Hypoglycemia
Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator.
Hypoglycemia
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.
Hypoglycemia
The novel use of a heterozygous knockout mouse for embryofetal development assessment of a glucokinase activator.
Hypoglycemia
The Relationship of Glucokinase Activator-induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies.
Hypoglycemia
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
Hypoglycemia
The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes.
Hypoglycemia
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.
Hypoglycemia
Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.
Hypothyroidism
Induction of oxidative stress, suppression of glucose-induced insulin release, ATP production, glucokinase activity, and histomorphometric changes in pancreatic islets of hypothyroid rat.
Hypothyroidism
The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats.
Infections
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment - A Stone Killing Two Birds?
Infections
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
Insulin Resistance
A dominant role for glucose in beta cell compensation of insulin resistance.
Insulin Resistance
A glucokinase gene mutation in a young boy with diabetes mellitus, hyperinsulinemia, and insulin resistance.
Insulin Resistance
Agonist: the case for insulin resistance as a necessary and sufficient cause of type II diabetes mellitus.
Insulin Resistance
Anti?diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat?rich combination diet
Insulin Resistance
Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver.
Insulin Resistance
Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats.
Insulin Resistance
Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivo.
Insulin Resistance
Chronically increased glucose uptake by adipose tissue leads to lactate production and improved insulin sensitivity rather than obesity in the mouse.
Insulin Resistance
Dairy Product Consumption Interacts with Glucokinase (GCK) Gene Polymorphisms Associated with Insulin Resistance.
Insulin Resistance
Development and regulation of glucose transporter and hexokinase expression in rat.
Insulin Resistance
Dipeptidyl peptidase-4 inhibitor anagliptin ameliorates diabetes in mice with haploinsufficiency of glucokinase on a high-fat diet.
Insulin Resistance
Evaluation of 90-day Repeated Dose Oral Toxicity, Glycometabolism, Learning and Memory Ability, and Related Enzyme of Chromium Malate Supplementation in Sprague-Dawley Rats.
Insulin Resistance
Evaluation of the Reproductive Toxicity, Glycometabolism, Glycometabolism-Related Enzyme Levels and Lipid Metabolism of Chromium Malate Supplementation in Sprague-Dawley Rats.
Insulin Resistance
Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect.
Insulin Resistance
F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck.
Insulin Resistance
Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites.
Insulin Resistance
G/A Polymorphism at -258 of the Hepatic Glucokinase Promoter Is Not Associated with Decreased Birth Weight in Preterm Neonates.
Insulin Resistance
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Insulin Resistance
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.
Insulin Resistance
Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome.
Insulin Resistance
Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation.
Insulin Resistance
Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians.
Insulin Resistance
High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP).
Insulin Resistance
Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects.
Insulin Resistance
Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes.
Insulin Resistance
Islet adaptive changes to fructose-induced insulin resistance: beta-cell mass, glucokinase, glucose metabolism, and insulin secretion.
Insulin Resistance
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus.
Insulin Resistance
Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.
Insulin Resistance
Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).
Insulin Resistance
Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.
Insulin Resistance
Low-Frequency Genetic Variant in the Hepatic Glucokinase Gene Is Associated With Type 2 Diabetes and Insulin Resistance in Chinese Population.
Insulin Resistance
Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells.
Insulin Resistance
Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort.
Insulin Resistance
Metabolomic and genetic associations with insulin resistance in pregnancy.
Insulin Resistance
New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer).
Insulin Resistance
Normal Glucose Metabolism in Carnivores Overlaps with Diabetes Pathology in Non-Carnivores.
Insulin Resistance
PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.
Insulin Resistance
Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice.
Insulin Resistance
Prevention of obesity and insulin resistance by glucokinase expression in skeletal muscle of transgenic mice.
Insulin Resistance
Rare Sugar Syrup Containing d-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats.
Insulin Resistance
Relationship between regional hepatic glucose metabolism and regional distribution of hepatic fat.
Insulin Resistance
Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes.
Insulin Resistance
Role of glucose-6 phosphatase, glucokinase, and glucose-6 phosphate in liver insulin resistance and its correction by metformin.
Insulin Resistance
The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles.
Insulin Resistance
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Insulin Resistance
Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes).
Insulin Resistance
[Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery]
Insulinoma
Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase.
Insulinoma
Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.
Insulinoma
An alternate promoter in the glucokinase gene is active in the pancreatic beta cell.
Insulinoma
Discrimination of glucose anomers by glucokinase from liver and transplantable insulinoma.
Insulinoma
Effect of retinoic acid on glucokinase activity and gene expression and on insulin secretion in primary cultures of pancreatic islets.
Insulinoma
Evaluation of the expression of hexokinase 1, glucokinase, and insulin by canine insulinoma cells maintained in short-term culture.
Insulinoma
Glucagon-like peptide 1 stimulates post-translational activation of glucokinase in pancreatic beta cells.
Insulinoma
Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization.
Insulinoma
Glucokinase gene structure. Functional implications of molecular genetic studies.
Insulinoma
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
Insulinoma
Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells.
Insulinoma
Hyperinsulinemic hypoglycemia without insulinoma: Think of activating glucokinase mutation.
Insulinoma
Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell.
Insulinoma
Insulin secretion, insulin content and glucose phosphorylation in RINm5F insulinoma cells after transfection with human GLUT2 glucose-transporter cDNA.
Insulinoma
Mannose phosphorylation by glucokinase from liver and transplantable insulinoma. Cooperativity and discrimination of anomers.
Insulinoma
Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase.
Insulinoma
Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells.
Insulinoma
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
Insulinoma
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
Insulinoma
Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2.
Ischemic Attack, Transient
Ischemic preconditioning maintains the immunoreactivities of glucokinase and glucokinase regulatory protein in neurons of the gerbil hippocampal CA1 region following transient cerebral ischemia.
Ischemic Attack, Transient
Time-course changes in immunoreactivities of glucokinase and glucokinase regulatory protein in the gerbil hippocampus following transient cerebral ischemia.
Ischemic Stroke
Functional Variants of Glucokinase Regulatory Protein and Apolipoprotein A5 Genes in Ischemic Stroke.
Ischemic Stroke
Polymorphisms in the GCKR are associated with serum lipid traits, the risk of coronary artery disease and ischemic stroke.
Ketosis
The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes.
Latent Autoimmune Diabetes in Adults
Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes.
Lipidoses
Discovery of piragliatin-first glucokinase activator studied in type 2 diabetic patients.
Liver Cirrhosis
Correction: glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Liver Cirrhosis
Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Liver Cirrhosis
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Diseases
A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis.
Liver Diseases
Association of GCKR Gene Polymorphisms with the Risk of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in a Chinese Northern Han Population.
Liver Diseases
Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.
Liver Diseases
Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.
Liver Diseases
Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis.
Liver Diseases
Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Nonalcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants.
Liver Diseases
Control of liver glucokinase activity: A potential new target for incretin hormones?
Liver Diseases
Correction: glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Liver Diseases
Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.
Liver Diseases
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.
Liver Diseases
Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Liver Diseases
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Diseases
Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort.
Liver Diseases
Non-alcoholic fatty liver disease concerns with glucokinase activators - Authors' reply.
Liver Diseases
[Clinical studies on the serum glucokinase activity values. 1. Erythrocyte glucokinase activity values in normal infants and children, in ekiri-like syndrome, in diabetes mellitus, and in liver diseases.]
Lymphoma, Non-Hodgkin
Intracellular localization of glucokinase and glycolytic enzymes in lymphosarcoma.
Malnutrition
Onset of carbon catabolite repression in Aspergillus nidulans. Parallel involvement of hexokinase and glucokinase in sugar signaling.
Malnutrition
Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism.
Melanoma, Experimental
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
Menkes Kinky Hair Syndrome
Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening.
Metabolic Diseases
Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism.
Metabolic Syndrome
Association Between a Glucokinase Regulator Genetic Variant and Metabolic Syndrome in Taiwanese Adolescents.
Metabolic Syndrome
Chronic ethanol consumption inhibits glucokinase transcriptional activity by Atf3 and triggers metabolic syndrome in vivo.
Metabolic Syndrome
GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults.
Metabolic Syndrome
Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome.
Metabolic Syndrome
Impact of Type 2 diabetes on Glucokinase diabetes (GCK-MODY) phenotype in a Roma (Gypsy) family - case report.
Metabolic Syndrome
Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects.
Multiple Endocrine Neoplasia
Thymic Carcinoid as the First Manifestation of Multiple Endocrine Neoplasia Type 1 Syndrome: A Case Report and Review of the Literature.
Multiple Endocrine Neoplasia Type 1
Thymic Carcinoid as the First Manifestation of Multiple Endocrine Neoplasia Type 1 Syndrome: A Case Report and Review of the Literature.
Myocardial Ischemia
NONRATT021972 long-noncoding RNA: A promising lncRNA in diabetes-related diseases.
Neoplasms
Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.
Neoplasms
Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice.
Neoplasms
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Neoplasms
Evaluation of the expression of hexokinase 1, glucokinase, and insulin by canine insulinoma cells maintained in short-term culture.
Neoplasms
Evidence for a major gene for type II diabetes and linkage analyses with selected candidate genes in Mexican-Americans.
Neoplasms
Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines.
Neoplasms
First evidence of changes in enzyme kinetics and stability of glucokinase affected by somatic cancer-associated variations.
Neoplasms
Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.
Neoplasms
High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose.
Neoplasms
Inhibitory effects of streptozotocin, tumor necrosis factor-alpha, and interleukin-1beta on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase.
Neoplasms
Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis.
Neoplasms
Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs.
Neoplasms
The association between Mediterranean Diet Score and glucokinase regulatory protein gene variation on the markers of cardiometabolic risk: an analysis in the European Prospective Investigation into Cancer (EPIC)-Norfolk study.
Neoplasms
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
Neoplasms
The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Neoplasms
Thymic Carcinoid as the First Manifestation of Multiple Endocrine Neoplasia Type 1 Syndrome: A Case Report and Review of the Literature.
Neoplasms
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ? cells.
Neoplasms
UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma.
Neoplasms
[13C6,D8]2-deoxyglucose phosphorylation by hexokinase shows selectivity for the ?-anomer.
Neoplasms
[Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis]
Neuroendocrine Tumors
Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells.
Non-alcoholic Fatty Liver Disease
A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study.
Non-alcoholic Fatty Liver Disease
A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis.
Non-alcoholic Fatty Liver Disease
Association of GCKR Gene Polymorphisms with the Risk of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in a Chinese Northern Han Population.
Non-alcoholic Fatty Liver Disease
Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.
Non-alcoholic Fatty Liver Disease
Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis.
Non-alcoholic Fatty Liver Disease
Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Nonalcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants.
Non-alcoholic Fatty Liver Disease
Correction: glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Non-alcoholic Fatty Liver Disease
Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.
Non-alcoholic Fatty Liver Disease
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease.
Non-alcoholic Fatty Liver Disease
Hormonal and Metabolite Regulation of Hepatic Glucokinase.
Non-alcoholic Fatty Liver Disease
Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort.
Non-alcoholic Fatty Liver Disease
New Perspectives in Pediatric Nonalcoholic Fatty Liver Disease: Epidemiology, Genetics, Diagnosis, and Natural History.
Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease concerns with glucokinase activators - Authors' reply.
Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease concerns with glucokinase activators.
Non-alcoholic Fatty Liver Disease
The rate of production of uric acid by hepatocytes is a sensitive index of compromised cell ATP homeostasis.
Obesity
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2.
Obesity
Cafeteria diet overfeeding in young male rats impairs the adaptive response to fed/fasted conditions and increases adiposity independent of body weight.
Obesity
Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
Obesity
Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a meta-analysis.
Obesity
Functional glucokinase regulator gene variants have inverse effects on triglyceride and glucose levels, and decrease the risk of obesity in children.
Obesity
Glucokinase Regulatory Protein (GCKR) Gene rs4425043 Polymorphism is Associated with Overweight and Obesity in Chinese Women.
Obesity
Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.
Obesity
Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.
Obesity
In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents.
Obesity
Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects.
Obesity
Prevention of obesity and insulin resistance by glucokinase expression in skeletal muscle of transgenic mice.
Obesity
Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring.
Obesity
The -30G>A polymorphism of the glucokinase gene promoter is associated with obesity in a population from southern Spain.
Obesity
[STUDY RELATIVE EXPRESSION OF GENES THAT CONTROL GLUCOSE METABOLISM IN THE LIVER IN MICE WITH DEVELOPMENT OF MELANOCORTIN OBESITY].
Obesity, Morbid
A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis.
Overweight
Glucokinase Regulatory Protein (GCKR) Gene rs4425043 Polymorphism is Associated with Overweight and Obesity in Chinese Women.
Paralysis
Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase.
Peripheral Nervous System Diseases
The Relationship of Glucokinase Activator-induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies.
Pituitary Neoplasms
Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: insulin secretion in response to physiological concentrations of glucose.
Pituitary Neoplasms
D-glucose transport and utilization in pituitary adenoma cells transfected with glucokinase gene.
Prediabetic State
10-year trajectory of ?-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study.
Prediabetic State
Characterization of hepatic glucose metabolism disorder with the progress of diabetes in male Spontaneously Diabetic Torii rats.
Prediabetic State
Production of a mouse strain with impaired glucose tolerance by systemic heterozygous knockout of the glucokinase gene and its feasibility as a prediabetes model.
Prostatic Neoplasms
A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study).
Protein Deficiency
The expression of growth-arrest genes in the liver and kidney of the protein-restricted rat fetus.
Psoriasis
[The skin activity of hexokinase, glucokinase and phosphofructokinase in psoriasis patients]
Renal Insufficiency, Chronic
Effect of Hepatic Organic Anion-Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver-Targeted Glucokinase Activator: A Model-Based Evaluation.
Renal Insufficiency, Chronic
Variants of GCKR Affect Both {beta}-Cell and Kidney Function in Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study 2.
Situs Inversus
Novel deletion mutation in the glucokinase gene from a korean man with GCK-MODY phenotype and situs inversus.
Starvation
Adaptation of glycolytic enzymes: glucose use and insulin release in rat pancreatic islets during fasting and refeeding.
Starvation
Effect of different thyroid states on rat liver glucokinase synthesis and degradation in vivo.
Starvation
Effects of succinic acid dimethyl ester infusion on metabolic, hormonal, and enzymatic variables in starved rats.
Starvation
Molecular cloning of hepatic glucose-6-phosphatase catalytic subunit from gilthead sea bream (Sparus aurata): response of its mRNA levels and glucokinase expression to refeeding and diet composition.
Starvation
Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells.
Starvation
Protective action of succinic acid monomethyl ester against the impairment of glucose-stimulated insulin release caused by glucopenia or starvation: metabolic determinants.
Starvation
Rapid action of insulin and cyclic AMP in the regulation of functional messenger RNA coding for glucokinase in rat liver.
Starvation
Reciprocal distribution of hexokinase and glucokinase in the periportal and perivenous zone of the rat liver acinus.
Starvation
Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells.
Starvation
Zonal expression of the glucokinase gene in rat liver. Dynamics during the daily feeding rhythm and starvation-refeeding cycle demonstrated by in situ hybridization.
Transfusion Reaction
[Glucokinase activity of the myocardium, skeletal muscles, kidneys and bone marrow in transfusion reactions in dogs]
Tuberculosis
Cg2091 encodes a polyphosphate/ATP-dependent glucokinase of Corynebacterium glutamicum.
Tuberculosis
Involvement of tryptophan(s) at the active site of polyphosphate/ATP glucokinase from Mycobacterium tuberculosis.
Tuberculosis
Purification of polyphosphate and ATP glucose phosphotransferase from Mycobacterium tuberculosis H37Ra: evidence that poly(P) and ATP glucokinase activities are catalyzed by the same enzyme.
Whooping Cough
Bordetella pertussis extract induces increase in the activities of glycolytic enzymes in mouse liver.
Highest Expressing Human Cell Lines
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NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
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SEQUENCE
LOCALIZATION PREDICTION
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SCOP
CATH
UNIPROT
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Release 2026.1 (March 2026)
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