Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

No. of entries

Information on EC 2.7.1.199 - protein-Npi-phosphohistidine-D-glucose phosphotransferase

for references in articles please use BRENDA:EC2.7.1.199

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate—protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.

The enzyme appears in viruses and cellular organisms

Synonyms
glucose transporter, iiaglc, glucose permease, iiglc, d-glucose transporter, enzyme iiglc, eiiglc, eiiaglc, iicbglc, sugar permease, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[protein]-Npi-phospho-L-histidine + D-glucose[side 1] = [protein]-L-histidine + D-glucose 6-phosphate[side 2]
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
glycolysis I (from glucose 6-phosphate)