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Information on EC 2.7.1.196 - protein-Npi-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase and Organism(s) Escherichia coli and UniProt Accession P69795

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IUBMB Comments
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
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Escherichia coli
UNIPROT: P69795
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The taxonomic range for the selected organisms is: Escherichia coli
The enzyme appears in selected viruses and cellular organisms
Synonyms
cellobiose permease, iicel, ii cel, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cellobiose permease
-
chb
-
operon
chbABC
-
-
-
-
chitobiose PTS permease
-
-
-
-
EIIcel
-
-
-
-
EIIchb
-
-
-
-
IIAChb
-
subunit
IIBChb
-
subunit
IIcel
-
-
-
-
Iichb
-
-
-
-
N,N'-diacetylchitobiose phosphotransferase system
-
-
N,N'-diacetylchitobiose PTS permease
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-Npi-phospho-L-histidine:N,N'-diacetylchitobiose Npi-phosphotransferase
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + N,N'-diacetylchitobiose[side 1]
[protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate[side 2]
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + N,N'-diacetylchitobiose[side 1]
[protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate[side 2]
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10480
-
subunit IIBChb, sedimentation equilibrium analysis
11431
-
1 * 11431, subunit IIBChb, calculated from amino acid sequence
12748
-
2 * 12748, subunit IIAChb, calculated from amino acid sequence
25200
-
subunit IIAChb, sedimentation equilibrium analysis
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
-
2 * 12748, subunit IIAChb, calculated from amino acid sequence
monomer
-
1 * 11431, subunit IIBChb, calculated from amino acid sequence
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Keyhani, N.; Rodgers, M.; Demeler, B.; Hansen, J.; Roseman, S.
Analytical sedimentation of the IIA(Chb) and IIB(Chb) proteins of the Escherichia coli N,N'-diacetylchitobiose phosphotransferase system. Demonstration of a model phosphotransfer transition state complex
J. Biol. Chem.
275
33110-33115
2000
Escherichia coli
Manually annotated by BRENDA team
Reizer, J.; Reizer, A.; Saier Jr., M.
The cellobiose permease of Escherichia coli consists of three proteins and is homologous to the lactose permease of Staphylococcus aureus
Res. Microbiol.
141
1061-1067
1990
Escherichia coli (P69795), Escherichia coli
Manually annotated by BRENDA team