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Disease on EC 2.7.1.194 - protein-Npi-phosphohistidine-L-ascorbate phosphotransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women.
Aggressive Periodontitis
SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis.
Alzheimer Disease
Vitamin C Deficiency in the Brain Impairs Cognition, Increases Amyloid Accumulation and Deposition, and Oxidative Stress in APP/PSEN1 and Normally Aging Mice.
Ascorbic Acid Deficiency
Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression.
Breast Neoplasms
Alterations in Hepatic mRNA Expression of Phase-II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 alpha.
Molecular expression and functional activity of vitamin C specific transport system (SVCT2) in human breast cancer cells.
SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment.
Transporters in the Mammary Gland-Contribution to Presence of Nutrients and Drugs into Milk.
Carcinogenesis
Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.
Cataract
Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract.
Choriocarcinoma
Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells.
Ascorbic Acid Uptaken by Sodium-Dependent Vitamin C Transporter 2 Induces ?hCG Expression through Sp1 and TFAP2A Transcription Factors in Human Choriocarcinoma Cells.
Chronic Periodontitis
SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis.
Colonic Neoplasms
L-Ascorbic acid can abrogate SVCT-2-dependent cetuximab resistance mediated by mutant KRAS in human colon cancer cells.
COVID-19
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection.
Diabetic Retinopathy
Ascorbate uptake in normal and diabetic rat retina and retinal pigment epithelium.
Head and Neck Neoplasms
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.
Huntington Disease
Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease.
Hyperlipidemias
Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes.
Infarction, Middle Cerebral Artery
Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain.
Infections
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection.
Liver Neoplasms
Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2.
Myocardial Ischemia
Genetically high plasma vitamin C, intake of fruit and vegetables, and risk of ischemic heart disease and all-cause mortality: a Mendelian randomization study.
Neoplasms
Mutation SVCT2 promotes cell proliferation, invasion and migration in colorectal cancer.
Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression.
Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.
Vitamin C Transporters and Their Implications in Carcinogenesis.
Osteoarthritis
Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues.
Peripheral Nerve Injuries
Sodium-dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation.
Squamous Cell Carcinoma of Head and Neck
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.
Stomach Neoplasms
Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.