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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
additional information
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[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
the L-ascorbate transporter is highly specific for L-ascorbate
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
the L-ascorbate transporter is highly specific for L-ascorbate
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
Halalkalibacterium halodurans
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
-
?
additional information
?
-
-
the sgaTBA genes of Escherichia coli encode a putative 12-transmembrane alpha-helical segment transporter, an enzyme IIB-like protein and an enzyme IIA-like protein of the phosphotransferase system, respectively. All three proteins as well as the energy-coupling phosphotransferase system proteins, enzyme I and HPr, are required for the anaerobic utilization and uptake of L-ascorbate in vivo and its phosphoenolpyruvatedependent phosphorylation in vitro
-
-
?
additional information
?
-
-
the sgaTBA genes of Escherichia coli encode a putative 12-transmembrane alpha-helical segment transporter, an enzyme IIB-like protein and an enzyme IIA-like protein of the phosphotransferase system, respectively. All three proteins as well as the energy-coupling phosphotransferase system proteins, enzyme I and HPr, are required for the anaerobic utilization and uptake of L-ascorbate in vivo and its phosphoenolpyruvatedependent phosphorylation in vitro
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
additional information
?
-
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
the L-ascorbate transporter is highly specific for L-ascorbate
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
the L-ascorbate transporter is highly specific for L-ascorbate
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
Halalkalibacterium halodurans
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
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-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
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?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1]
[protein]-L-histidine + L-ascorbate 6-phosphate[side 2]
-
-
-
-
?
additional information
?
-
-
the sgaTBA genes of Escherichia coli encode a putative 12-transmembrane alpha-helical segment transporter, an enzyme IIB-like protein and an enzyme IIA-like protein of the phosphotransferase system, respectively. All three proteins as well as the energy-coupling phosphotransferase system proteins, enzyme I and HPr, are required for the anaerobic utilization and uptake of L-ascorbate in vivo and its phosphoenolpyruvatedependent phosphorylation in vitro
-
-
?
additional information
?
-
-
the sgaTBA genes of Escherichia coli encode a putative 12-transmembrane alpha-helical segment transporter, an enzyme IIB-like protein and an enzyme IIA-like protein of the phosphotransferase system, respectively. All three proteins as well as the energy-coupling phosphotransferase system proteins, enzyme I and HPr, are required for the anaerobic utilization and uptake of L-ascorbate in vivo and its phosphoenolpyruvatedependent phosphorylation in vitro
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acute Coronary Syndrome
Variation in the Sodium-Dependent Vitamin C Transporter 2 Gene Is Associated with Risk of Acute Coronary Syndrome among Women.
Aggressive Periodontitis
SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis.
Alzheimer Disease
Vitamin C Deficiency in the Brain Impairs Cognition, Increases Amyloid Accumulation and Deposition, and Oxidative Stress in APP/PSEN1 and Normally Aging Mice.
Ascorbic Acid Deficiency
Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression.
Breast Neoplasms
Alterations in Hepatic mRNA Expression of Phase-II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 alpha.
Breast Neoplasms
Molecular expression and functional activity of vitamin C specific transport system (SVCT2) in human breast cancer cells.
Breast Neoplasms
SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment.
Breast Neoplasms
Transporters in the Mammary Gland-Contribution to Presence of Nutrients and Drugs into Milk.
Carcinogenesis
Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.
Cataract
Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract.
Choriocarcinoma
Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells.
Choriocarcinoma
Ascorbic Acid Uptaken by Sodium-Dependent Vitamin C Transporter 2 Induces ?hCG Expression through Sp1 and TFAP2A Transcription Factors in Human Choriocarcinoma Cells.
Chronic Periodontitis
SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis.
Colonic Neoplasms
L-Ascorbic acid can abrogate SVCT-2-dependent cetuximab resistance mediated by mutant KRAS in human colon cancer cells.
COVID-19
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection.
Diabetic Retinopathy
Ascorbate uptake in normal and diabetic rat retina and retinal pigment epithelium.
Head and Neck Neoplasms
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.
Huntington Disease
Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease.
Hyperlipidemias
Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes.
Infarction, Middle Cerebral Artery
Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain.
Infections
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.
Infections
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection.
Liver Neoplasms
Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2.
Myocardial Ischemia
Genetically high plasma vitamin C, intake of fruit and vegetables, and risk of ischemic heart disease and all-cause mortality: a Mendelian randomization study.
Neoplasms
Mutation SVCT2 promotes cell proliferation, invasion and migration in colorectal cancer.
Neoplasms
Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression.
Neoplasms
Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.
Neoplasms
Vitamin C Transporters and Their Implications in Carcinogenesis.
Osteoarthritis
Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues.
Peripheral Nerve Injuries
Sodium-dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation.
Squamous Cell Carcinoma of Head and Neck
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.
Stomach Neoplasms
Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Zhang, Z.; Aboulwafa, M.; Smith, M.; Saier Jr., M.
The ascorbate transporter of Escherichia coli
J. Bacteriol.
185
2243-2250
2003
Escherichia coli, Escherichia coli BW25113
brenda
Hvorup, R.; Chang, A.B.; Saier, M.H.
Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family
J. Mol. Microbiol. Biotechnol.
6
191-205
2003
Halalkalibacterium halodurans, Leuconostoc mesenteroides, Corynebacterium glutamicum, Clostridium perfringens, Streptococcus pneumoniae, Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Lactiplantibacillus plantarum, Listeria innocua, Listeria monocytogenes, Staphylococcus aureus, Mycoplasma pneumoniae, Oceanobacillus iheyensis, Pasteurella multocida, Yersinia pestis, Salmonella enterica subsp. enterica serovar Typhimurium, Shigella flexneri, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus mutans, Streptomyces coelicolor, Vibrio parahaemolyticus, Caldanaerobacter subterraneus subsp. tengcongensis, Mycoplasmopsis pulmonis, Vibrio vulnificus, Malacoplasma penetrans, Vibrio cholerae serotype O1, Streptococcus agalactiae 2603 V/R, Corynebacterium glutamicum ATCC 13032, Vibrio vulnificus CMCP6, Leuconostoc mesenteroides ATCC 8293, Shigella flexneri 301, Staphylococcus aureus MW2, Streptococcus mutans UA159
brenda
Luo, P.; Yu, X.; Wang, W.; Fan, S.; Li, X.; Wang, J.
Crystal structure of a phosphorylation-coupled vitamin C transporter
Nat. Struct. Mol. Biol.
22
238-241
2015
Escherichia coli (P39301), Escherichia coli
brenda
Luo, P.; Dai, S.; Zeng, J.; Duan, J.; Shi, H.; Wang, J.
Inward-facing conformation of L-ascorbate transporter suggests an elevator mechanism
Cell Discov.
4
35
2018
Pasteurella multocida (Q9CMQ1), Pasteurella multocida, Pasteurella multocida Pm70 (Q9CMQ1)
brenda