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Information on EC - protein-Npi-phosphohistidine-D-mannose phosphotransferase

for references in articles please use BRENDA:EC2.7.1.191
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IUBMB Comments
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
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The enzyme appears in viruses and cellular organisms
D-glucosaminate PTS permease component EIIA, D-glucosaminate PTS permease component EIIB, D-glucosaminate PTS permease component EIIC, D-glucosaminate PTS permease component EIID, dgaABCD, EII, EII man, EII(t)Man, EIIABCDman, EIIMan, more
[protein]-Npi-phospho-L-histidine + D-mannose[side 1] = [protein]-L-histidine + D-mannose 6-phosphate[side 2]
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