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IUBMB Comments The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.
Synonyms
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AcbM
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ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate
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ATP:2-epi-5-epi-valiolone 7-phosphotransferase
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.
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ATP + 1-epi-2-epi-5-epi-valiolol
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ATP + 2-epi-5-epi-valiolol
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ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
ATP + 1-epi-2-epi-5-epi-valiolol
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Substrates: -
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ATP + 1-epi-2-epi-5-epi-valiolol
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Substrates: -
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ATP + 2-epi-5-epi-valiolol
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Substrates: -
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ATP + 2-epi-5-epi-valiolol
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Substrates: -
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ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
Substrates: the enzyme is involved in the biosynthesis of acarbose
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ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
Substrates: -
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ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
Substrates: the enzyme is involved in the biosynthesis of acarbose
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ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
Substrates: -
?
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ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
Substrates: the enzyme is involved in the biosynthesis of acarbose
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ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
Substrates: the enzyme is involved in the biosynthesis of acarbose
?
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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Gene Links
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physiological function
the enzyme is involved in the biosynthesis of acarbose
physiological function
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the enzyme is involved in the biosynthesis of acarbose
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ACBM_ACTS5
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
359
0
36943
Swiss-Prot
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expressed in strains of Streptomyces lividans 66 strains 1326, TK23, and TK64
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Zhang, C.S.; Stratmann, A.; Block, O.; Brckner, R.; Podeschwa, M.; Altenbach, H.J.; Wehmeier, U.F.; Piepersberg, W.
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-Phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway
J. Biol. Chem.
277
22853-22862
2002
Actinoplanes sp. (Q8RIS8), Actinoplanes sp. 50/110 (Q8RIS8)
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