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Information on EC 2.7.1.182 - phytol kinase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9LZ76

for references in articles please use BRENDA:EC2.7.1.182
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IUBMB Comments
The enzyme is found in plants and photosynthetic algae and is involved in phytol salvage . It can use UTP as an alternative phosphate donor with lower activity .
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9LZ76
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
phytol kinase, slvte5, at5g04490, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
CTP:phytol O-phosphotransferase
The enzyme is found in plants and photosynthetic algae [2] and is involved in phytol salvage [1]. It can use UTP as an alternative phosphate donor with lower activity [2].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + phytol
ADP + phytyl phosphate
show the reaction diagram
about 7times less activity than with CTP
-
-
?
CTP + phytol
CDP + phytyl phosphate
show the reaction diagram
GTP + phytol
GDP + phytyl phosphate
show the reaction diagram
about 7times less activity than with CTP
-
-
?
UTP + phytol
UDP + phytyl phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CTP + phytol
CDP + phytyl phosphate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the growth defect of vte6-1 is alleviated in the vte5-2/vte6-1 double mutant. The tocopherol-deficient mutants vte1, vte2, vte4, and vte5 can grow on soil and produce fertile seeds, while vte6-1 and vte6-2 cannot grow photoautotrophically and are infertile. Amounts of phytol are unchanged in vte5-2 and vte5-2/vte6-1 mutants compared with the wild-type
metabolism
phytol from chlorophyll degradation can be phosphorylated to phytyl-phosphate by phytol kinase, EC 2.7.1.182, and to phytyl-diphosphate, the substrate for tocopherol (vitamin E) synthesis by phytyl-diphosphate kinase, EC 2.7.4.BX. Tocopherol synthesis in leaves depends on phytol derived from chlorophyll, not on de novo synthesis of phytyl-diphosphate from geranylgeranyl-diphosphate. The phytol phosphorylation pathway is essential for plant growth and development
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PHYK1_ARATH
304
6
33090
Swiss-Prot
Chloroplast (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
gene VTE5, recombinant functional expression of gene VTE5 or functional coexpression of genes VTE5 and VTE6 in Escherichia coli, quantitative real-time PCR expression analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Valentin, H.E.; Lincoln, K.; Moshiri, F.; Jensen, P.K.; Qi, Q.; Venkatesh, T.V.; Karunanandaa, B.; Baszis, S.R.; Norris, S.R.; Savidge, B.; Gruys, K.J.; Last, R.L.
The Arabidopsis vitamin E pathway gene5-1 mutant reveals a critical role for phytol kinase in seed tocopherol biosynthesis
Plant Cell
18
212-224
2006
Arabidopsis thaliana (Q9LZ76), Arabidopsis thaliana, Synechocystis sp. (P74653), Synechocystis sp.
Manually annotated by BRENDA team
Ischebeck, T.; Zbierzak, A.M.; Kanwischer, M.; Doermann, P.
A salvage pathway for phytol metabolism in Arabidopsis
J. Biol. Chem.
281
2470-2477
2006
Arabidopsis thaliana (Q9LZ76)
Manually annotated by BRENDA team
Vom Dorp, K.; Hoelzl, G.; Plohmann, C.; Eisenhut, M.; Abraham, M.; Weber, A.P.; Hanson, A.D.; Doermann, P.
Remobilization of phytol from chlorophyll degradation is essential for tocopherol synthesis and growth of Arabidopsis
Plant Cell
27
2846-2859
2015
Arabidopsis thaliana (Q9LZ76), Arabidopsis thaliana
Manually annotated by BRENDA team