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BRENDA support

Information on EC 2.7.1.178 - 2-dehydro-3-deoxyglucono/galactono-kinase

for references in articles please use BRENDA:EC2.7.1.178

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IUBMB Comments

The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC 2.7.1.45, 2-dehydro-3-deoxygluconokinase and EC 2.7.1.58, 2-dehydro-3-deoxygalactonokinase.

The expected taxonomic range for this enzyme is: Archaea, Bacteria

Synonyms
2-keto-3-deoxy-D-gluconate kinase, 2-keto-3-deoxygalactonate kinase, 2-keto-3-deoxygluconate kinase, 2-keto-3-deoxyglucononate kinase, HVO_0549, HVO_A0328, KDG kinase, KDGK, KDGK-1, KDGK-2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate
show the reaction diagram
ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
3,6-anhydro-alpha-L-galactopyranose degradation, 4-deoxy-L-threo-hex-4-enopyranuronate degradation, alginate degradation, D-fructuronate degradation, D-galactonate degradation, D-galacturonate degradation I, Entner-Doudoroff pathway III (semi-phosphorylative), L-glucose degradation
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